@article{JedrusikBodeStudenckaSmolkaetal.2013, author = {Jedrusik-Bode, Monika and Studencka, Maja and Smolka, Christian and Baumann, Tobias and Schmidt, Henning and Kampf, Jan and Paap, Franziska and Martin, Sophie and Tazi, Jamal and M{\"u}ller, Kristian M. and Kr{\"u}ger, Marcus and Braun, Thomas and Bober, Eva}, title = {The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals}, series = {Journal of cell science}, volume = {126}, journal = {Journal of cell science}, number = {22}, publisher = {Company of Biologists Limited}, address = {Cambridge}, issn = {0021-9533}, doi = {10.1242/jcs.130708}, pages = {5166 -- +}, year = {2013}, abstract = {SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.}, language = {en} } @misc{LohwasserWendlandReinhardtetal.2022, author = {Lohwaßer, Roswitha and Wendland, Mirko and Reinhardt, Felix and Halibrand, Katharina and Deiseroth, Laura and Jennek, Julia and Strobel, Anne and Hackel, Manuela and Kr{\"u}ger, Sophie and Fischer, Tom and Bosse, Stefanie and Florian, Lena and Fabian, Melina and Israel, Franziska and Iffert, Mathias and Hintze, Ksenia and Wendland, Mirko and Egbert, Bj{\"o}rn and Heinz, Sarah and Bock, Sophia and Mutschler, Tanja and Burchard, Daniel and Musil, Andreas}, title = {Kentron : Journal zur Lehrerbildung = AHA Moment}, number = {35}, publisher = {Universit{\"a}t Potsdam, Zentrum f{\"u}r Lehrerbildung}, address = {Potsdam}, issn = {1867-4720}, doi = {10.25932/publishup-59042}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-590429}, pages = {67}, year = {2022}, language = {de} }