@article{WarringtonBeaumontHorikoshietal.2019, author = {Warrington, Nicole and Beaumont, Robin and Horikoshi, Momoko and Day, Felix R. and Helgeland, {\O}yvind and Laurin, Charles and Bacelis, Jonas and Peng, Shouneng and Hao, Ke and Feenstra, Bjarke and Wood, Andrew R. and Mahajan, Anubha and Tyrrell, Jessica and Robertson, Neil R. and Rayner, N. William and Qiao, Zhen and Moen, Gunn-Helen and Vaudel, Marc and Marsit, Carmen and Chen, Jia and Nodzenski, Michael and Schnurr, Theresia M. and Zafarmand, Mohammad Hadi and Bradfield, Jonathan P. and Grarup, Niels and Kooijman, Marjolein N. and Li-Gao, Ruifang and Geller, Frank and Ahluwalia, Tarunveer Singh and Paternoster, Lavinia and Rueedi, Rico and Huikari, Ville and Hottenga, Jouke-Jan and Lyytik{\"a}inen, Leo-Pekka and Cavadino, Alana and Metrustry, Sarah and Cousminer, Diana L. and Wu, Ying and Thiering, Elisabeth Paula and Wang, Carol A. and Have, Christian Theil and Vilor-Tejedor, Natalia and Joshi, Peter K. and Painter, Jodie N. and Ntalla, Ioanna and Myhre, Ronny and Pitk{\"a}nen, Niina and van Leeuwen, Elisabeth M. and Joro, Raimo and Lagou, Vasiliki and Richmond, Rebecca C. and Espinosa, Ana and Barton, Sheila J. and Inskip, Hazel M. and Holloway, John W. and Santa-Marina, Loreto and Estivill, Xavier and Ang, Wei and Marsh, Julie A. and Reichetzeder, Christoph and Marullo, Letizia and Hocher, Berthold and Lunetta, Kathryn L. and Murabito, Joanne M. and Relton, Caroline L. and Kogevinas, Manolis and Chatzi, Leda and Allard, Catherine and Bouchard, Luigi and Hivert, Marie-France and Zhang, Ge and Muglia, Louis J. and Heikkinen, Jani and Morgen, Camilla S. and van Kampen, Antoine H. C. and van Schaik, Barbera D. C. and Mentch, Frank D. and Langenberg, Claudia and Scott, Robert A. and Zhao, Jing Hua and Hemani, Gibran and Ring, Susan M. and Bennett, Amanda J. and Gaulton, Kyle J. and Fernandez-Tajes, Juan and van Zuydam, Natalie R. and Medina-Gomez, Carolina and de Haan, Hugoline G. and Rosendaal, Frits R. and Kutalik, Zolt{\´a}n and Marques-Vidal, Pedro and Das, Shikta and Willemsen, Gonneke and Mbarek, Hamdi and M{\"u}ller-Nurasyid, Martina and Standl, Marie and Appel, Emil V. R. and Fonvig, Cilius Esmann and Trier, Caecilie and van Beijsterveldt, Catharina E. M. and Murcia, Mario and Bustamante, Mariona and Bon{\`a}s-Guarch, S{\´i}lvia and Hougaard, David M. and Mercader, Josep M. and Linneberg, Allan and Schraut, Katharina E. and Lind, Penelope A. and Medland, Sarah Elizabeth and Shields, Beverley M. and Knight, Bridget A. and Chai, Jin-Fang and Panoutsopoulou, Kalliope and Bartels, Meike and S{\´a}nchez, Friman and Stokholm, Jakob and Torrents, David and Vinding, Rebecca K. and Willems, Sara M. and Atalay, Mustafa and Chawes, Bo L. and Kovacs, Peter and Prokopenko, Inga and Tuke, Marcus A. and Yaghootkar, Hanieh and Ruth, Katherine S. and Jones, Samuel E. and Loh, Po-Ru and Murray, Anna and Weedon, Michael N. and T{\"o}njes, Anke and Stumvoll, Michael and Michaelsen, Kim Fleischer and Eloranta, Aino-Maija and Lakka, Timo A. and van Duijn, Cornelia M. and Kiess, Wieland and Koerner, Antje and Niinikoski, Harri and Pahkala, Katja and Raitakari, Olli T. and Jacobsson, Bo and Zeggini, Eleftheria and Dedoussis, George V. and Teo, Yik-Ying and Saw, Seang-Mei and Montgomery, Grant W. and Campbell, Harry and Wilson, James F. and Vrijkotte, Tanja G. M. and Vrijheid, Martine and de Geus, Eco J. C. N. and Hayes, M. Geoffrey and Kadarmideen, Haja N. and Holm, Jens-Christian and Beilin, Lawrence J. and Pennell, Craig E. and Heinrich, Joachim and Adair, Linda S. and Borja, Judith B. and Mohlke, Karen L. and Eriksson, Johan G. and Widen, Elisabeth E. and Hattersley, Andrew T. and Spector, Tim D. and Kaehoenen, Mika and Viikari, Jorma S. and Lehtimaeki, Terho and Boomsma, Dorret I. and Sebert, Sylvain and Vollenweider, Peter and Sorensen, Thorkild I. A. and Bisgaard, Hans and Bonnelykke, Klaus and Murray, Jeffrey C. and Melbye, Mads and Nohr, Ellen A. and Mook-Kanamori, Dennis O. and Rivadeneira, Fernando and Hofman, Albert and Felix, Janine F. and Jaddoe, Vincent W. V. and Hansen, Torben and Pisinger, Charlotta and Vaag, Allan A. and Pedersen, Oluf and Uitterlinden, Andre G. and Jarvelin, Marjo-Riitta and Power, Christine and Hypponen, Elina and Scholtens, Denise M. and Lowe, William L. and Smith, George Davey and Timpson, Nicholas J. and Morris, Andrew P. and Wareham, Nicholas J. and Hakonarson, Hakon and Grant, Struan F. A. and Frayling, Timothy M. and Lawlor, Debbie A. and Njolstad, Pal R. and Johansson, Stefan and Ong, Ken K. and McCarthy, Mark I. and Perry, John R. B. and Evans, David M. and Freathy, Rachel M.}, title = {Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {5}, publisher = {Nature Publ. Group}, address = {New York}, organization = {EGG Consortium}, issn = {1061-4036}, pages = {804 -- +}, year = {2019}, abstract = {Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.}, language = {en} } @article{AliuArchambaultArlenetal.2012, author = {Aliu, E. and Archambault, S. and Arlen, T. and Aune, T. and Beilicke, M. and Benbow, W. and Bouvier, A. and Buckley, J. H. and Bugaev, V. and Byrum, K. and Cesarini, A. and Ciupik, L. and Collins-Hughes, E. and Connolly, M. P. and Cui, W. and Dickherber, R. and Duke, C. and Dumm, J. and Falcone, A. and Federici, S. and Feng, Q. and Finley, J. P. and Finnegan, G. and Fortson, L. and Furniss, A. and Galante, N. and Gall, D. and Gillanders, G. H. and Godambe, S. and Griffin, S. and Grube, J. and Gyuk, G. and Hanna, D. and Holder, J. and Huan, H. and Hughes, G. and Humensky, T. B. and Kaaret, P. and Karlsson, N. and Khassen, Y. and Kieda, D. and Krawczynski, H. and Krennrich, F. and Lang, M. J. and LeBohec, S. and Lee, K. and Lyutikov, M. and Madhavan, A. S. and Maier, G. and Majumdar, P. and McArthur, S. and McCann, A. and Moriarty, P. and Mukherjee, R. and Nelson, T. and de Bhroithe, A. O'Faolain and Ong, R. A. and Orr, M. and Otte, A. N. and Park, N. and Perkins, J. S. and Pohl, M. and Prokoph, H. and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Roache, E. and Saxon, D. B. and Schr{\"o}dter, M. and Sembroski, G. H. and Sentuerk, G. D. and Smith, A. W. and Staszak, D. and Telezhinsky, Igor O. and Tesic, G. and Theiling, M. and Thibadeau, S. and Tsurusaki, K. and Varlotta, A. and Vincent, S. and Vivier, M. and Wagner, R. G. and Wakely, S. P. and Weekes, T. C. and Weinstein, A. and Welsing, R. and Williams, D. A. and Zitzer, B. and Kondratiev, V.}, title = {SEARCH FOR A CORRELATION BETWEEN VERY-HIGH-ENERGY GAMMA RAYS AND GIANT RADIO PULSES IN THE CRAB PULSAR}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {760}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/760/2/136}, pages = {13}, year = {2012}, abstract = {We present the results of a joint observational campaign between the Green Bank radio telescope and the VERITAS gamma-ray telescope, which searched for a correlation between the emission of very-high-energy (VHE) gamma rays (E-gamma > 150 GeV) and giant radio pulses (GRPs) from the Crab pulsar at 8.9 GHz. A total of 15,366 GRPs were recorded during 11.6 hr of simultaneous observations, which were made across four nights in 2008 December and in 2009 November and December. We searched for an enhancement of the pulsed gamma-ray emission within time windows placed around the arrival time of the GRP events. In total, eight different time windows with durations ranging from 0.033 ms to 72 s were positioned at three different locations relative to the GRP to search for enhanced gamma-ray emission which lagged, led, or was concurrent with, the GRP event. Furthermore, we performed separate searches on main pulse GRPs and interpulse GRPs and on the most energetic GRPs in our data sample. No significant enhancement of pulsed VHE emission was found in any of the preformed searches. We set upper limits of 5-10 times the average VHE flux of the Crab pulsar on the flux simultaneous with interpulse GRPs on single-rotation-period timescales. On similar to 8 s timescales around interpulse GRPs, we set an upper limit of 2-3 times the average VHE flux. Within the framework of recent models for pulsed VHE emission from the Crab pulsar, the expected VHE-GRP emission correlations are below the derived limits.}, language = {en} } @article{ArlenAuneBeilickeetal.2013, author = {Arlen, T. and Aune, T. and Beilicke, M. and Benbow, W. and Bouvier, A. and Buckley, J. H. and Bugaev, V. and Cesarini, A. and Ciupik, L. and Connolly, M. P. and Cui, W. and Dickherber, R. and Dumm, J. and Errando, M. and Falcone, A. and Federici, S. and Feng, Q. and Finley, J. P. and Finnegan, G. and Fortson, L. and Furniss, A. and Galante, N. and Gall, D. and Griffin, S. and Grube, J. and Gyuk, G. and Hanna, D. and Holder, J. and Humensky, T. B. and Kaaret, P. and Karlsson, N. and Kertzman, M. and Khassen, Y. and Kieda, D. and Krawczynski, H. and Krennrich, F. and Maier, G. and Moriarty, P. and Mukherjee, R. and Nelson, T. and de Bhroithe, A. O'Faolain and Ong, R. A. and Orr, M. and Park, N. and Perkins, J. S. and Pichel, A. and Pohl, Martin and Prokoph, H. and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Roache, E. and Saxon, D. B. and Schroedter, M. and Sembroski, G. H. and Staszak, D. and Telezhinsky, Igor O. and Tesic, G. and Theiling, M. and Tsurusaki, K. and Varlotta, A. and Vincent, S. and Wakely, S. P. and Weekes, T. C. and Weinstein, A. and Welsing, R. and Williams, D. A. and Zitzer, B. and Jorstad, S. G. and MacDonald, N. R. and Marscher, A. P. and Smith, P. S. and Walker, R. C. and Hovatta, T. and Richards, J. and Max-Moerbeck, W. and Readhead, A. and Lister, M. L. and Kovalev, Y. Y. and Pushkarev, A. B. and Gurwell, M. A. and Lahteenmaki, A. and Nieppola, E. and Tornikoski, M. and Jarvela, E.}, title = {Rapid TeV Gamma-Ray flaring of bl lacertae}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {762}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, organization = {VERITAS Collaboration}, issn = {0004-637X}, doi = {10.1088/0004-637X/762/2/92}, pages = {13}, year = {2013}, abstract = {We report on the detection of a very rapid TeV gamma-ray flare from BL Lacertae on 2011 June 28 with the Very Energetic Radiation Imaging Telescope Array System (VERITAS). The flaring activity was observed during a 34.6 minute exposure, when the integral flux above 200 GeV reached (3.4 +/- 0.6) x 10(-6) photons m(-2) s(-1), roughly 125\% of the Crab Nebula flux measured by VERITAS. The light curve indicates that the observations missed the rising phase of the flare but covered a significant portion of the decaying phase. The exponential decay time was determined to be 13 +/- 4 minutes, making it one of the most rapid gamma-ray flares seen from a TeV blazar. The gamma-ray spectrum of BL Lacertae during the flare was soft, with a photon index of 3.6 +/- 0.4, which is in agreement with the measurement made previously by MAGIC in a lower flaring state. Contemporaneous radio observations of the source with the Very Long Baseline Array revealed the emergence of a new, superluminal component from the core around the time of the TeV gamma-ray flare, accompanied by changes in the optical polarization angle. Changes in flux also appear to have occurred at optical, UV, and GeV gamma-ray wavelengths at the time of the flare, although they are difficult to quantify precisely due to sparse coverage. A strong flare was seen at radio wavelengths roughly four months later, which might be related to the gamma-ray flaring activities. We discuss the implications of these multiwavelength results.}, language = {en} } @article{AliuArchambaultArlenetal.2013, author = {Aliu, E. and Archambault, S. and Arlen, T. and Aune, T. and Beilicke, M. and Benbow, W. and Bird, R. and Boettcher, Markus and Bouvier, A. and Bugaev, V. and Byrum, K. and Cesarini, A. and Ciupik, L. and Collins-Hughes, E. and Connolly, M. P. and Cui, W. and Dickherber, R. and Duke, C. and Dumm, J. and Errando, M. and Falcone, A. and Federici, Simone and Feng, Q. and Finley, J. P. and Finnegan, G. and Fortson, L. and Furniss, A. and Galante, N. and Gall, D. and Gillanders, G. H. and Griffin, S. and Grube, J. and Gyuk, G. and Hanna, D. and Holder, J. and Hughes, G. and Humensky, T. B. and Kaaret, P. and Kertzman, M. and Khassen, Y. and Kieda, D. and Krawczynski, H. and Krennrich, F. and Lang, M. J. and Madhavan, A. S. and Maier, G. and Majumdar, P. and McArthur, S. and McCann, A. and Moriarty, P. and Mukherjee, R. and Nelson, T. and de Bhroithe, A. O'Faolain and Ong, R. A. and Orr, M. and Otte, A. N. and Park, N. and Perkins, J. S. and Pichel, A. and Pohl, Martin and Popkow, A. and Prokoph, H. and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Roache, E. and Saxon, D. B. and Schroedter, M. and Sembroski, G. H. and Skole, C. and Smith, A. W. and Staszak, D. and Telezhinsky, Igor O. and Theiling, M. and Tyler, J. and Varlotta, A. and Vassiliev, V. V. and Wakely, S. P. and Weekes, T. C. and Weinstein, A. and Welsing, R. and Williams, D. A. and Zitzer, B.}, title = {Multiwavelenght observations and modeling of 1ES 1959+650 in a low flux state}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {775}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/775/1/3}, pages = {8}, year = {2013}, abstract = {We report on the VERITAS observations of the high-frequency peaked BL Lac object 1ES 1959+650 in the period 2007-2011. This source is detected at TeV energies by VERITAS at 16.4 standard deviation (sigma) significance in 7.6 hr of observation in a low flux state. A multiwavelength spectral energy distribution (SED) is constructed from contemporaneous data from VERITAS, Fermi-LAT, RXTE PCA, and Swift UVOT. Swift XRT data is not included in the SED due to a lack of simultaneous observations with VERITAS. In contrast to the orphan gamma-ray flare exhibited by this source in 2002, the X-ray flux of the source is found to vary by an order of magnitude, while other energy regimes exhibit less variable emission. A quasi-equilibrium synchrotron self-Compton model with an additional external radiation field is used to describe three SEDs corresponding to the lowest, highest, and average X-ray states. The variation in the X-ray spectrum is modeled by changing the electron injection spectral index, with minor adjustments of the kinetic luminosity in electrons. This scenario produces small-scale flux variability of the order of less than or similar to 2 in the high energy (E > 1MeV) and very high energy (E > 100 GeV) gamma-ray regimes, which is corroborated by the Fermi-LAT, VERITAS, and Whipple 10 m telescope light curves.}, language = {en} } @article{MiddeldorpMahajanHorikoshietal.2019, author = {Middeldorp, Christel M. and Mahajan, Anubha and Horikoshi, Momoko and Robertson, Neil R. and Beaumont, Robin N. and Bradfield, Jonathan P. and Bustamante, Mariona and Cousminer, Diana L. and Day, Felix R. and De Silva, N. Maneka and Guxens, Monica and Mook-Kanamori, Dennis O. and St Pourcain, Beate and Warrington, Nicole M. and Adair, Linda S. and Ahlqvist, Emma and Ahluwalia, Tarunveer Singh and Almgren, Peter and Ang, Wei and Atalay, Mustafa and Auvinen, Juha and Bartels, Meike and Beckmann, Jacques S. and Bilbao, Jose Ramon and Bond, Tom and Borja, Judith B. and Cavadino, Alana and Charoen, Pimphen and Chen, Zhanghua and Coin, Lachlan and Cooper, Cyrus and Curtin, John A. and Custovic, Adnan and Das, Shikta and Davies, Gareth E. and Dedoussis, George V. and Duijts, Liesbeth and Eastwood, Peter R. and Eliasen, Anders U. and Elliott, Paul and Eriksson, Johan G. and Estivill, Xavier and Fadista, Joao and Fedko, Iryna O. and Frayling, Timothy M. and Gaillard, Romy and Gauderman, W. James and Geller, Frank and Gilliland, Frank and Gilsanz, Vincente and Granell, Raquel and Grarup, Niels and Groop, Leif and Hadley, Dexter and Hakonarson, Hakon and Hansen, Torben and Hartman, Catharina A. and Hattersley, Andrew T. and Hayes, M. Geoffrey and Hebebrand, Johannes and Heinrich, Joachim and Helgeland, Oyvind and Henders, Anjali K. and Henderson, John and Henriksen, Tine B. and Hirschhorn, Joel N. and Hivert, Marie-France and Hocher, Berthold and Holloway, John W. and Holt, Patrick and Hottenga, Jouke-Jan and Hypponen, Elina and Iniguez, Carmen and Johansson, Stefan and Jugessur, Astanand and Kahonen, Mika and Kalkwarf, Heidi J. and Kaprio, Jaakko and Karhunen, Ville and Kemp, John P. and Kerkhof, Marjan and Koppelman, Gerard H. and Korner, Antje and Kotecha, Sailesh and Kreiner-Moller, Eskil and Kulohoma, Benard and Kumar, Ashish and Kutalik, Zoltan and Lahti, Jari and Lappe, Joan M. and Larsson, Henrik and Lehtimaki, Terho and Lewin, Alexandra M. and Li, Jin and Lichtenstein, Paul and Lindgren, Cecilia M. and Lindi, Virpi and Linneberg, Allan and Liu, Xueping and Liu, Jun and Lowe, William L. and Lundstrom, Sebastian and Lyytikainen, Leo-Pekka and Ma, Ronald C. W. and Mace, Aurelien and Magi, Reedik and Magnus, Per and Mamun, Abdullah A. and Mannikko, Minna and Martin, Nicholas G. and Mbarek, Hamdi and McCarthy, Nina S. and Medland, Sarah E. and Melbye, Mads and Melen, Erik and Mohlke, Karen L. and Monnereau, Claire and Morgen, Camilla S. and Morris, Andrew P. and Murray, Jeffrey C. and Myhre, Ronny and Najman, Jackob M. and Nivard, Michel G. and Nohr, Ellen A. and Nolte, Ilja M. and Ntalla, Ioanna and Oberfield, Sharon E. and Oken, Emily and Oldehinkel, Albertine J. and Pahkala, Katja and Palviainen, Teemu and Panoutsopoulou, Kalliope and Pedersen, Oluf and Pennell, Craig E. and Pershagen, Goran and Pitkanen, Niina and Plomin, Robert and Power, Christine and Prasad, Rashmi B. and Prokopenko, Inga and Pulkkinen, Lea and Raikkonen, Katri and Raitakari, Olli T. and Reynolds, Rebecca M. and Richmond, Rebecca C. and Rivadeneira, Fernando and Rodriguez, Alina and Rose, Richard J. and Salem, Rany and Santa-Marina, Loreto and Saw, Seang-Mei and Schnurr, Theresia M. and Scott, James G. and Selzam, Saskia and Shepherd, John A. and Simpson, Angela and Skotte, Line and Sleiman, Patrick M. A. and Snieder, Harold and Sorensen, Thorkild I. A. and Standl, Marie and Steegers, Eric A. P. and Strachan, David P. and Straker, Leon and Strandberg, Timo and Taylor, Michelle and Teo, Yik-Ying and Thiering, Elisabeth and Torrent, Maties and Tyrrell, Jessica and Uitterlinden, Andre G. and van Beijsterveldt, Toos and van der Most, Peter J. and van Duijn, Cornelia M. and Viikari, Jorma and Vilor-Tejedor, Natalia and Vogelezang, Suzanne and Vonk, Judith M. and Vrijkotte, Tanja G. M. and Vuoksimaa, Eero and Wang, Carol A. and Watkins, William J. and Wichmann, H-Erich and Willemsen, Gonneke and Williams, Gail M. and Wilson, James F. and Wray, Naomi R. and Xu, Shujing and Xu, Cheng-Jian and Yaghootkar, Hanieh and Yi, Lu and Zafarmand, Mohammad Hadi and Zeggini, Eleftheria and Zemel, Babette S. and Hinney, Anke and Lakka, Timo A. and Whitehouse, Andrew J. O. and Sunyer, Jordi and Widen, Elisabeth E. and Feenstra, Bjarke and Sebert, Sylvain and Jacobsson, Bo and Njolstad, Pal R. and Stoltenberg, Camilla and Smith, George Davey and Lawlor, Debbie A. and Paternoster, Lavinia and Timpson, Nicholas J. and Ong, Ken K. and Bisgaard, Hans and Bonnelykke, Klaus and Jaddoe, Vincent W. V. and Tiemeier, Henning and Jarvelin, Marjo-Riitta and Evans, David M. and Perry, John R. B. and Grant, Struan F. A. and Boomsma, Dorret I. and Freathy, Rachel M. and McCarthy, Mark I. and Felix, Janine F.}, title = {The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia}, series = {European journal of epidemiology}, volume = {34}, journal = {European journal of epidemiology}, number = {3}, publisher = {Springer}, address = {Dordrecht}, organization = {EArly Genetics Lifecourse EGG Consortium EGG Membership EAGLE Membership}, issn = {0393-2990}, doi = {10.1007/s10654-019-00502-9}, pages = {279 -- 300}, year = {2019}, abstract = {The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.}, language = {en} } @article{AcciariAliuArayaetal.2011, author = {Acciari, V. A. and Aliu, E. and Araya, M. and Arlen, T. and Aune, T. and Beilicke, M. and Benbow, W. and Bradbury, S. M. and Buckley, J. H. and Bugaev, V. and Byrum, K. and Cannon, A. and Cesarini, A. and Ciupik, L. and Collins-Hughes, E. and Cui, W. and Dickherber, R. and Duke, C. and Falcone, A. and Finley, J. P. and Fortson, L. and Furniss, A. and Galante, N. and Gall, D. and Godambe, S. and Griffin, S. and Guenette, R. and Gyuk, G. and Hanna, D. and Holder, J. and Hughes, G. and Hui, C. M. and Humensky, T. B. and Imran, A. and Kaaret, P. and Kertzman, M. and Krawczynski, H. and Krennrich, F. and Madhavan, A. S. and Maier, G. and Majumdar, P. and McArthur, S. and Moriarty, P. and Ong, R. A. and Otte, A. N. and Pandel, D. and Park, N. and Perkins, J. S. and Pohl, Martin and Prokoph, H. and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Roache, E. and Rose, H. J. and Saxon, D. B. and Sembroski, G. H. and Sentuerk, G. D. and Smith, A. W. and Tesic, G. and Theiling, M. and Thibadeau, S. and Varlotta, A. and Vincent, S. and Vivier, M. and Wakely, S. P. and Ward, J. E. and Weekes, T. C. and Weinstein, A. and Weisgarber, T. and Weng, S. and Williams, D. A. and Wood, M. and Zitzer, B.}, title = {Gamma-ray observations of the Be/Pulsar binary 1A 0535+262 during a Giant X-Ray outburst}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {733}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/733/2/96}, pages = {10}, year = {2011}, abstract = {Giant X-ray outbursts, with luminosities of about 10(37) erg s(-1), are observed roughly every five years from the nearby Be/pulsar binary 1A 0535+262. In this article, we present observations of the source with VERITAS at very high energies (VHEs; E > 100 GeV) triggered by the X-ray outburst in 2009 December. The observations started shortly after the onset of the outburst and provided comprehensive coverage of the episode, as well as the 111 day binary orbit. No VHE emission is evident at any time. We also examined data from the contemporaneous observations of 1A 0535+262 with the Fermi/Large Area Telescope at high-energy photons (E > 0.1 GeV) and failed to detect the source at GeV energies. The X-ray continua measured with the Swift/X-Ray Telescope and the RXTE/PCA can be well described by the combination of blackbody and Comptonized emission from thermal electrons. Therefore, the gamma-ray and X-ray observations suggest the absence of a significant population of non-thermal particles in the system. This distinguishes 1A 0535+262 from those Be X-ray binaries (such as PSR B1259-63 and LS I +61 degrees 303) that have been detected at GeV-TeV energies. We discuss the implications of the results on theoretical models.}, language = {en} } @article{BarlowGreigBridgesetal.2002, author = {Barlow, S. M. and Greig, J. B. and Bridges, J. W. and Carere, A. and Carpy, A. J. and Galli, Corrado L. and Kleiner, J. and Knudsen, I. and Koeter, H. B. and Levy, L. S. and Madsen, C. and Mayer, S. and Narbonne, J. F. and Pfannkuch, F. and Prodanchuk, M. G. and Smith, Mason R. and Steinberg, Pablo}, title = {Hazard identification by methods of animal-based toxicology}, year = {2002}, language = {en} } @article{AbeysekaraBenbowBirdetal.2018, author = {Abeysekara, A. U. and Benbow, Wystan and Bird, Ralph and Brantseg, T. and Brose, Robert and Buchovecky, M. and Buckley, J. H. and Bugaev, V. and Connolly, M. P. and Cui, Wei and Daniel, M. K. and Falcone, A. and Feng, Qi and Finley, John P. and Fortson, L. and Furniss, Amy and Gillanders, Gerard H. and Gunawardhana, Isuru and Huetten, M. and Hanna, David and Hervet, O. and Holder, J. and Hughes, G. and Humensky, T. B. and Johnson, Caitlin A. and Kaaret, Philip and Kar, P. and Kertzman, M. and Krennrich, F. and Lang, M. J. and Lin, T. T. Y. and McArthur, S. and Moriarty, P. and Mukherjee, Reshmi and Ong, R. A. and Otte, Adam Nepomuk and Park, N. and Petrashyk, A. and Pohl, Martin and Pueschel, Elisa and Quinn, J. and Ragan, K. and Reynolds, P. T. and Richards, Gregory T. and Roache, E. and Rulten, C. and Sadeh, I. and Santander, M. and Sembroski, G. H. and Shahinyan, Karlen and Wakely, S. P. and Weinstein, A. and Wells, R. M. and Wilcox, P. and Williams, D. A. and Zitzer, B. and Jorstad, Svetlana G. and Marscher, Alan P. and Lister, Matthew L. and Kovalev, Yuri Y. and Pushkarev, A. B. and Savolainen, Tuomas and Agudo, I. and Molina, S. N. and Gomez, J. L. and Larionov, Valeri M. and Borman, G. A. and Mokrushina, A. A. and Tornikoski, Merja and Lahteenmaki, A. and Chamani, W. and Enestam, S. and Kiehlmann, S. and Hovatta, Talvikki and Smith, P. S. and Pontrelli, P.}, title = {Multiwavelength Observations of the Blazar BL Lacertae}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {856}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, organization = {VERITAS Collaboration}, issn = {0004-637X}, doi = {10.3847/1538-4357/aab35c}, pages = {14}, year = {2018}, abstract = {Combined with measurements made by very-long-baseline interferometry, the observations of fast TeV gamma-ray flares probe the structure and emission mechanism of blazar jets. However, only a handful of such flares have been detected to date, and only within the last few years have these flares been observed from lower-frequency-peaked BL. Lac objects and flat-spectrum radio quasars. We report on a fast TeV gamma-ray flare from the blazar BL. Lacertae observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS). with a rise time of similar to 2.3 hr and a decay time of similar to 36 min. The peak flux above 200 GeV is (4.2 +/- 0.6) x 10(-6) photon m(-2) s(-1) measured with a 4-minute-binned light curve, corresponding to similar to 180\% of the flux that is observed from the Crab Nebula above the same energy threshold. Variability contemporaneous with the TeV gamma-ray flare was observed in GeV gamma-ray, X-ray, and optical flux, as well as in optical and radio polarization. Additionally, a possible moving emission feature with superluminal apparent velocity was identified in Very Long Baseline Array observations at 43 GHz, potentially passing the radio core of the jet around the time of the gamma-ray flare. We discuss the constraints on the size, Lorentz factor, and location of the emitting region of the flare, and the interpretations with several theoretical models that invoke relativistic plasma passing stationary shocks.}, language = {en} } @article{TownsleyBroosCorcoranetal.2011, author = {Townsley, Leisa K. and Broos, Patrick S. and Corcoran, Michael F. and Feigelson, Eric D. and Gagne, Marc and Montmerle, Thierry and Oey, M. S. and Smith, Nathan and Garmire, Gordon P. and Getman, Konstantin V. and Povich, Matthew S. and Evans, Nancy Remage and Naze, Yael and Parkin, E. R. and Preibisch, Thomas and Wang, Junfeng and Wou, Scott J. and Chu, You-Hua and Cohen, David H. and Gruendl, Robert A. and Hamaguchi, Kenji and King, Robert R. and Mac Low, Mordecai-Mark and McCaughrean, Mark J. and Moffat, Anthony F. J. and Oskinova, Lida and Pittard, Julian M. and Stassun, Keivan G. and Ud-Doula, Asif and Walborn, Nolan R. and Waldron, Wayne L. and Churchwell, Ed and Nictiols, J. S. and Owocki, Stanley P. and Schulz, Norbert S.}, title = {An introduction to the chandra carina complex project}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, volume = {194}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0067-0049}, doi = {10.1088/0067-0049/194/1/1}, pages = {28}, year = {2011}, abstract = {The Great Nebula in Carina provides an exceptional view into the violent massive star formation and feedback that typifies giant H II regions and starburst galaxies. We have mapped the Carina star-forming complex in X-rays, using archival Chandra data and a mosaic of 20 new 60 ks pointings using the Chandra X-ray Observatory's Advanced CCD Imaging Spectrometer, as a testbed for understanding recent and ongoing star formation and to probe Carina's regions of bright diffuse X-ray emission. This study has yielded a catalog of properties of > 14,000 X-ray point sources;> 9800 of them have multiwavelength counterparts. Using Chandra's unsurpassed X-ray spatial resolution, we have separated these point sources from the extensive, spatially-complex diffuse emission that pervades the region; X-ray properties of this diffuse emission suggest that it traces feedback from Carina's massive stars. In this introductory paper, we motivate the survey design, describe the Chandra observations, and present some simple results, providing a foundation for the 15 papers that follow in this special issue and that present detailed catalogs, methods, and science results.}, language = {en} } @article{vanderValkKreinerMollerKooijmanetal.2015, author = {van der Valk, Ralf J. P. and Kreiner-Moller, Eskil and Kooijman, Marjolein N. and Guxens, Monica and Stergiakouli, Evangelia and Saaf, Annika and Bradfield, Jonathan P. and Geller, Frank and Hayes, M. Geoffrey and Cousminer, Diana L. and Koerner, Antje and Thiering, Elisabeth and Curtin, John A. and Myhre, Ronny and Huikari, Ville and Joro, Raimo and Kerkhof, Marjan and Warrington, Nicole M. and Pitkanen, Niina and Ntalla, Ioanna and Horikoshi, Momoko and Veijola, Riitta and Freathy, Rachel M. and Teo, Yik-Ying and Barton, Sheila J. and Evans, David M. and Kemp, John P. and St Pourcain, Beate and Ring, Susan M. and Smith, George Davey and Bergstrom, Anna and Kull, Inger and Hakonarson, Hakon and Mentch, Frank D. and Bisgaard, Hans and Chawes, Bo Lund Krogsgaard and Stokholm, Jakob and Waage, Johannes and Eriksen, Patrick and Sevelsted, Astrid and Melbye, Mads and van Duijn, Cornelia M. and Medina-Gomez, Carolina and Hofman, Albert and de Jongste, Johan C. and Taal, H. Rob and Uitterlinden, Andre G. and Armstrong, Loren L. and Eriksson, Johan and Palotie, Aarno and Bustamante, Mariona and Estivill, Xavier and Gonzalez, Juan R. and Llop, Sabrina and Kiess, Wieland and Mahajan, Anubha and Flexeder, Claudia and Tiesler, Carla M. T. and Murray, Clare S. and Simpson, Angela and Magnus, Per and Sengpiel, Verena and Hartikainen, Anna-Liisa and Keinanen-Kiukaanniemi, Sirkka and Lewin, Alexandra and Alves, Alexessander Da Silva Couto and Blakemore, Alexandra I. F. and Buxton, Jessica L. and Kaakinen, Marika and Rodriguez, Alina and Sebert, Sylvain and Vaarasmaki, Marja and Lakka, Timo and Lindi, Virpi and Gehring, Ulrike and Postma, Dirkje S. and Ang, Wei and Newnham, John P. and Lyytikainen, Leo-Pekka and Pahkala, Katja and Raitakari, Olli T. and Panoutsopoulou, Kalliope and Zeggini, Eleftheria and Boomsma, Dorret I. and Groen-Blokhuis, Maria and Ilonen, Jorma and Franke, Lude and Hirschhorn, Joel N. and Pers, Tune H. and Liang, Liming and Huang, Jinyan and Hocher, Berthold and Knip, Mikael and Saw, Seang-Mei and Holloway, John W. and Melen, Erik and Grant, Struan F. A. and Feenstra, Bjarke and Lowe, William L. and Widen, Elisabeth and Sergeyev, Elena and Grallert, Harald and Custovic, Adnan and Jacobsson, Bo and Jarvelin, Marjo-Riitta and Atalay, Mustafa and Koppelman, Gerard H. and Pennell, Craig E. and Niinikoski, Harri and Dedoussis, George V. and Mccarthy, Mark I. and Frayling, Timothy M. and Sunyer, Jordi and Timpson, Nicholas J. and Rivadeneira, Fernando and Bonnelykke, Klaus and Jaddoe, Vincent W. V.}, title = {A novel common variant in DCST2 is associated with length in early life and height in adulthood}, series = {Human molecular genetics}, volume = {24}, journal = {Human molecular genetics}, number = {4}, publisher = {Oxford Univ. Press}, address = {Oxford}, organization = {Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG}, issn = {0964-6906}, doi = {10.1093/hmg/ddu510}, pages = {1155 -- 1168}, year = {2015}, abstract = {Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05\%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13\% of variance in birth length. The same SNPs explained 2.95\% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.}, language = {en} } @article{KikstraNichollsSmithetal.2022, author = {Kikstra, Jarmo S. and Nicholls, Zebedee R. J. and Smith, Christopher J. and Lewis, Jared and Lamboll, Robin D. and Byers, Edward and Sandstad, Marit and Meinshausen, Malte and Gidden, Matthew J. and Rogelj, Joeri and Kriegler, Elmar and Peters, Glen P. and Fuglestvedt, Jan S. and Skeie, Ragnhild B. and Samset, Bj{\o}rn H. and Wienpahl, Laura and van Vuuren, Detlef P. and van der Wijst, Kaj-Ivar and Al Khourdajie, Alaa and Forster, Piers M. and Reisinger, Andy and Schaeffer, Roberto and Riahi, Keywan}, title = {The IPCC Sixth Assessment Report WGIII climate assessment of mitigation pathways}, series = {Geoscientific model development}, volume = {15}, journal = {Geoscientific model development}, number = {24}, publisher = {Copernicus}, address = {Katlenburg-Lindau}, issn = {1991-959X}, doi = {10.5194/gmd-15-9075-2022}, pages = {9075 -- 9109}, year = {2022}, abstract = {While the Intergovernmental Panel on Climate Change (IPCC) physical science reports usually assess a handful of future scenarios, the Working Group III contribution on climate mitigation to the IPCC's Sixth Assessment Report (AR6 WGIII) assesses hundreds to thousands of future emissions scenarios. A key task in WGIII is to assess the global mean temperature outcomes of these scenarios in a consistent manner, given the challenge that the emissions scenarios from different integrated assessment models (IAMs) come with different sectoral and gas-to-gas coverage and cannot all be assessed consistently by complex Earth system models. In this work, we describe the "climate-assessment" workflow and its methods, including infilling of missing emissions and emissions harmonisation as applied to 1202 mitigation scenarios in AR6 WGIII. We evaluate the global mean temperature projections and effective radiative forcing (ERF) characteristics of climate emulators FaIRv1.6.2 and MAGICCv7.5.3 and use the CICERO simple climate model (CICERO-SCM) for sensitivity analysis. We discuss the implied overshoot severity of the mitigation pathways using overshoot degree years and look at emissions and temperature characteristics of scenarios compatible with one possible interpretation of the Paris Agreement. We find that the lowest class of emissions scenarios that limit global warming to "1.5 ∘C (with a probability of greater than 50 \%) with no or limited overshoot" includes 97 scenarios for MAGICCv7.5.3 and 203 for FaIRv1.6.2. For the MAGICCv7.5.3 results, "limited overshoot" typically implies exceedance of median temperature projections of up to about 0.1 ∘C for up to a few decades before returning to below 1.5 ∘C by or before the year 2100. For more than half of the scenarios in this category that comply with three criteria for being "Paris-compatible", including net-zero or net-negative greenhouse gas (GHG) emissions, median temperatures decline by about 0.3-0.4 ∘C after peaking at 1.5-1.6 ∘C in 2035-2055. We compare the methods applied in AR6 with the methods used for SR1.5 and discuss their implications. This article also introduces a "climate-assessment" Python package which allows for fully reproducing the IPCC AR6 WGIII temperature assessment. This work provides a community tool for assessing the temperature outcomes of emissions pathways and provides a basis for further work such as extending the workflow to include downscaling of climate characteristics to a regional level and calculating impacts.}, language = {en} } @article{SeroussiNowickiPayneetal.2020, author = {Seroussi, Helene and Nowicki, Sophie and Payne, Antony J. and Goelzer, Heiko and Lipscomb, William H. and Abe-Ouchi, Ayako and Agosta, Cecile and Albrecht, Torsten and Asay-Davis, Xylar and Barthel, Alice and Calov, Reinhard and Cullather, Richard and Dumas, Christophe and Galton-Fenzi, Benjamin K. and Gladstone, Rupert and Golledge, Nicholas R. and Gregory, Jonathan M. and Greve, Ralf and Hattermann, Tore and Hoffman, Matthew J. and Humbert, Angelika and Huybrechts, Philippe and Jourdain, Nicolas C. and Kleiner, Thomas and Larour, Eric and Leguy, Gunter R. and Lowry, Daniel P. and Little, Chistopher M. and Morlighem, Mathieu and Pattyn, Frank and Pelle, Tyler and Price, Stephen F. and Quiquet, Aurelien and Reese, Ronja and Schlegel, Nicole-Jeanne and Shepherd, Andrew and Simon, Erika and Smith, Robin S. and Straneo, Fiammetta and Sun, Sainan and Trusel, Luke D. and Van Breedam, Jonas and van de Wal, Roderik S. W. and Winkelmann, Ricarda and Zhao, Chen and Zhang, Tong and Zwinger, Thomas}, title = {ISMIP6 Antarctica}, series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, volume = {14}, journal = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, number = {9}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1994-0416}, doi = {10.5194/tc-14-3033-2020}, pages = {3033 -- 3070}, year = {2020}, abstract = {Ice flow models of the Antarctic ice sheet are commonly used to simulate its future evolution in response to different climate scenarios and assess the mass loss that would contribute to future sea level rise. However, there is currently no consensus on estimates of the future mass balance of the ice sheet, primarily because of differences in the representation of physical processes, forcings employed and initial states of ice sheet models. This study presents results from ice flow model simulations from 13 international groups focusing on the evolution of the Antarctic ice sheet during the period 2015-2100 as part of the Ice Sheet Model Intercomparison for CMIP6 (ISMIP6). They are forced with outputs from a subset of models from the Coupled Model Intercomparison Project Phase 5 (CMIP5), representative of the spread in climate model results. Simulations of the Antarctic ice sheet contribution to sea level rise in response to increased warming during this period varies between 7:8 and 30.0 cm of sea level equivalent (SLE) under Representative Concentration Pathway (RCP) 8.5 scenario forcing. These numbers are relative to a control experiment with constant climate conditions and should therefore be added to the mass loss contribution under climate conditions similar to present-day conditions over the same period. The simulated evolution of the West Antarctic ice sheet varies widely among models, with an overall mass loss, up to 18.0 cm SLE, in response to changes in oceanic conditions. East Antarctica mass change varies between 6 :1 and 8.3 cm SLE in the simulations, with a significant increase in surface mass balance outweighing the increased ice discharge under most RCP 8.5 scenario forcings. The inclusion of ice shelf collapse, here assumed to be caused by large amounts of liquid water ponding at the surface of ice shelves, yields an additional simulated mass loss of 28mm compared to simulations without ice shelf collapse. The largest sources of uncertainty come from the climate forcing, the ocean-induced melt rates, the calibration of these melt rates based on oceanic conditions taken outside of ice shelf cavities and the ice sheet dynamic response to these oceanic changes. Results under RCP 2.6 scenario based on two CMIP5 climate models show an additional mass loss of 0 and 3 cm of SLE on average compared to simulations done under present-day conditions for the two CMIP5 forcings used and display limited mass gain in East Antarctica.}, language = {en} } @article{D'HondtSpivackPockalnyetal.2009, author = {D'Hondt, Steven and Spivack, Arthur J. and Pockalny, Robert and Ferdelman, Timothy G. and Fischer, Jan P. and Kallmeyer, Jens and Abrams, Lewis J. and Smith, David C. and Graham, Dennis and Hasiuk, Franciszek and Schrum, Heather and Stancin, Andrea M.}, title = {Subseafloor sedimentary life in the South Pacific Gyre}, issn = {0027-8424}, doi = {10.1073/pnas.0811793106}, year = {2009}, abstract = {The low-productivity South Pacific Gyre (SPG) is Earth's largest oceanic province. Its sediment accumulates extraordinarily slowly (0.1-1 m per million years). This sediment contains a living community that is characterized by very low biomass and very low metabolic activity. At every depth in cored SPG sediment, mean cell abundances are 3 to 4 orders of magnitude lower than at the same depths in all previously explored subseafloor communities. The net rate of respiration by the subseafloor sedimentary community at each SPG site is 1 to 3 orders of magnitude lower than the rates at previously explored sites. Because of the low respiration rates and the thinness of the sediment, interstitial waters are oxic throughout the sediment column in most of this region. Consequently, the sedimentary community of the SPG is predominantly aerobic, unlike previously explored subseafloor communities. Generation of H-2 by radiolysis of water is a significant electron-donor source for this community. The per-cell respiration rates of this community are about 2 orders of magnitude higher (in oxidation/reduction equivalents) than in previously explored anaerobic subseafloor communities. Respiration rates and cell concentrations in subseafloor sediment throughout almost half of the world ocean may approach those in SPG sediment.}, language = {en} } @article{SmithBarlowRosenthaletal.2022, author = {Smith, Bryce A. and Barlow, Brad N. and Rosenthal, Benjamin and Hermes, J. J. and Schaffenroth, Veronika}, title = {Pulse Timing Discovery of a Three-day Companion to the Hot Subdwarf BPM 36430}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {939}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.3847/1538-4357/ac9384}, pages = {6}, year = {2022}, abstract = {Hot subdwarf B stars are core-helium-burning objects that have undergone envelope stripping, likely by a binary companion. Using high-speed photometry from the Transiting Exoplanet Survey Satellite, we have discovered the hot subdwarf BPM 36430 is a hybrid sdBV(rs) pulsator exhibiting several low-amplitude g-modes and a strong p-mode pulsation. The latter shows a clear, periodic variation in its pulse arrival times. Fits to this phase oscillation imply BPM 36430 orbits a barycenter approximately 10 light-seconds away once every 3.1 days. Using the CHIRON echelle spectrograph on the CTIO 1.5 m telescope, we confirm the reflex motion by detecting a radial-velocity variation with semiamplitude, period, and phase in agreement with the pulse timings. We conclude that a white dwarf companion with minimum mass of approximate to 0.42 M (circle dot) orbits BPM 36430. Our study represents only the second time a companion orbiting a pulsating hot subdwarf or white dwarf has been detected from pulse timings and confirmed with radial velocities.}, language = {en} } @article{GeistGallagherKotullaetal.2022, author = {Geist, Emily and Gallagher, John S. and Kotulla, Ralf and Oskinova, Lida and Hamann, Wolf-Rainer and Ramachandran, Varsha and Sabbi, Elena and Smith, Linda J. and Kniazev, Alexey and Nota, Antonella and Rickard, Matthew J.}, title = {Ionization and star formation in the giant H ii region SMC-N66}, series = {Publications of the Astronomical Society of the Pacific}, volume = {134}, journal = {Publications of the Astronomical Society of the Pacific}, number = {1036}, publisher = {IOP Publishing}, address = {Bristol}, issn = {0004-6280}, doi = {10.1088/1538-3873/ac697b}, pages = {11}, year = {2022}, abstract = {The NGC 346 young stellar system and associated N66 giant H ii region in the Small Magellanic Cloud are the nearest example of a massive star-forming event in a low metallicity (Z approximate to 0.2Z (circle dot)) galaxy. With an age of less than or similar to 3 Myr this system provides a unique opportunity to study relationships between massive stars and their associated H ii region. Using archival data, we derive a total H alpha luminosity of L(H alpha) = 4.1 x 10(38) erg s(-1) corresponding to an H-photoionization rate of 3 x 10(50) s(-1). A comparison with a predicted stellar ionization rate derived from the more than 50 known O-stars in NGC 346, including massive stars recently classified from Hubble Space Telescope far-ultraviolet (FUV) spectra, indicates an approximate ionization balance. Spectra obtained with SALT suggest the ionization structure of N66 could be consistent with some leakage of ionizing photons. Due to the low metallicity, the FUV luminosity from NGC 346 is not confined to the interstellar cloud associated with N66. Ionization extends through much of the spatial extent of the N66 cloud complex, and most of the cloud mass is not ionized. The stellar mass estimated from nebular L(H alpha) appears to be lower than masses derived from the census of resolved stars which may indicate a disconnect between the formation of high and low mass stars in this region. We briefly discuss implications of the properties of N66 for studies of star formation and stellar feedback in low metallicity environments.}, language = {en} } @article{CrightonProchaskaMurphyetal.2019, author = {Crighton, Neil H. M. and Prochaska, J. Xavier and Murphy, Michael T. and Worseck, Gabor and Smith, Britton D.}, title = {Imprints of the first billion years}, series = {Monthly notices of the Royal Astronomical Society}, volume = {482}, journal = {Monthly notices of the Royal Astronomical Society}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/sty2762}, pages = {1456 -- 1470}, year = {2019}, abstract = {Lyman limit systems (LLSs) trace the low-density circumgalactic medium and the most dense regions of the intergalactic medium, so their number density and evolution at high-redshift, just after reionization, are important to constrain. We present a survey for LLSs at high redshifts, z(LLS) = 3.5-5.4, in the homogeneous data set of 153 optical quasar spectra at z similar to 5 from the Giant Gemini GMOS survey. Our analysis includes detailed investigation of survey biases using mock spectra which provide important corrections to the raw measurements. We estimate the incidence of LLSs per unit redshift at z approximate to 4.4 to be l(z) = 2.6 +/- 0.4. Combining our results with previous surveys at z(LLS) < 4, the best-fit power-law evolution is l(z) = l(*)[(1 + z)/4](alpha) with l* = 1.46 +/- 0.11 and alpha = 1.70 +/- 0.22 (68 per cent confidence intervals). Despite hints in previous z(LLS) < 4 results, there is no indication for a deviation from this single power-law soon after reionization. Finally, we integrate our new results with previous surveys of the intergalactic and circumgalactic media to constrain the hydrogen column density distribution function, f(N-HI, X), over 10 orders ofmagnitude. The data at z similar to 5 are not well-described by the f(N-HI, X) model previously reported for z similar to 2-3 (after re-scaling) and a 7-pivot model fitting the full z similar to 2-5 data set is statistically unacceptable. We conclude that there is significant evolution in the shape of f(N-HI, X) over this similar to 2-billion-year period.}, language = {en} } @article{EigmuellerChaushevGillenetal.2019, author = {Eigm{\"u}ller, Philipp and Chaushev, Alexander and Gillen, Edward and Smith, Alexis and Nielsen, Louise D. and Turner, Oliver and Csizmadia, Szilard and Smalley, Barry and Bayliss, Daniel and Belardi, Claudia and Bouchy, Francois and Burleigh, Matthew R. and Cabrera, Juan and Casewell, Sarah L. and Chazelas, Bruno and Cooke, Benjamin F. and Erikson, Anders and Gansicke, Boris T. and Guenther, Maximilian N. and Goad, Michael R. and Grange, Andrew and Jackman, James A. G. and Jenkins, James S. and McCormac, James and Moyano, Maximiliano and Pollacco, Don and Poppenh{\"a}ger, Katja and Queloz, Didier and Raynard, Liam and Rauer, Heike and Udry, Stephane and Walker, Simon. R. and Watson, Christopher A. and West, Richard G. and Wheatley, Peter J.}, title = {NGTS-5b}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {625}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201935206}, pages = {9}, year = {2019}, abstract = {Context. Planetary population analysis gives us insight into formation and evolution processes. For short-period planets, the sub-Jovian desert has been discussed in recent years with regard to the planet population in the mass/period and radius/period parameter space without taking stellar parameters into account. The Next Generation Transit Survey (NGTS) is optimised for detecting planets in this regime, which allows for further analysis of the sub-Jovian desert. Aims. With high-precision photometric surveys (e.g. with NGTS and TESS), which aim to detect short period planets especially around M/K-type host stars, stellar parameters need to be accounted for when empirical data are compared to model predictions. Presenting a newly discovered planet at the boundary of the sub-Jovian desert, we analyse its bulk properties and use it to show the properties of exoplanets that border the sub-Jovian desert. Methods. Using NGTS light curve and spectroscopic follow-up observations, we confirm the planetary nature of planet NGTS-5b and determine its mass. Using exoplanet archives, we set the planet in context with other discoveries. Results. NGTS-5b is a short-period planet with an orbital period of 3.3569866 +/- 0.0000026 days. With a mass of 0.229 +/- 0.037 M-Jup and a radius of 1.136 +/- 0.023 R-Jup, it is highly inflated. Its mass places it at the upper boundary of the sub-Jovian desert. Because the host is a K2 dwarf, we need to account for the stellar parameters when NGTS-5b is analysed with regard to planet populations. Conclusions. With red-sensitive surveys (e.g. with NGTS and TESS), we expect many more planets around late-type stars to be detected. An empirical analysis of the sub-Jovian desert should therefore take stellar parameters into account.}, language = {en} } @article{NuthmannSmithEngbertetal.2010, author = {Nuthmann, Antje and Smith, Tim J. and Engbert, Ralf and Henderson, John M.}, title = {CRISP: a computational model of fixation duration in scene viewing}, year = {2010}, abstract = {Eye-movement control during scene viewing can be represented as a series of individual decisions about where and when to move the eyes. While substantial behavioral and computational research has been devoted to investigating the placement of fixations in scenes, relatively little is known about the mechanisms that control fixation durations. Here, we propose a computational model (CRISP) that accounts for saccade timing and programming and thus for variations in fixation durations in scene viewing. First, timing signals are modeled as continuous-time random walks. Second, difficulties at the level of visual and cognitive processing can inhibit and thus modulate saccade timing. Inhibition generates moment-by-moment changes in the random walk's transition rate and processing-related saccade cancellation. Third, saccade programming is completed in 2 stages: an initial, labile stage that is subject to cancellation and a subsequent, nonlabile stage. Several simulation studies tested the model's adequacy and generality. An initial simulation study explored the role of cognitive factors in scene viewing by examining how fixation durations differed under different viewing task instructions. Additional simulations investigated the degree to which fixation durations were under direct moment-to-moment control of the current visual scene. The present work further supports the conclusion that fixation durations, to a certain degree, reflect perceptual and cognitive activity in scene viewing. Computational model simulations contribute to an understanding of the underlying processes of gaze control.}, language = {en} } @article{MacarusoLockeSmithetal.1996, author = {Macaruso, P. and Locke, J. and Smith, S. T. and Powers, Susan M.}, title = {Short-term Memory and phonological coding in develomental dyslexis}, year = {1996}, language = {en} } @article{KrupnikWagnerVincentetal.2022, author = {Krupnik, Seweryn and Wagner, Aleksandra and Vincent, Olga and Rudek, Tadeusz J. and Wade, Robert and Misik, Mat{\´u}š and Akerboom, Sanne and Foulds, Chris and Smith Stegen, Karen and Adem, {\c{C}}iğdem and Batel, Susana and Rabitz, Florian and Certom{\`a}, Chiara and Chodkowska-Miszczuk, Justyna and Dokupilov{\´a}, Dušana and Leiren, Merethe D. and Ignatieva, Frolova M. and Gabald{\´o}n-Estevan, Daniel. and Horta, Ana and Karn{\o}e, Peter and Lilliestam, Johan and Loorbach, Derk A. and M{\"u}hlemeier, Susan and N{\´e}moz, Sophie and Nilsson, M{\aa}ns and Osička, Jan and Papamikrouli, Louiza and Pellizioni, Luigi and Sareen, Siddharth and Sarrica, Mauro and Seyfang, Gill and Sovacool, Benjamin K. and Telesiene, Audrone and Zapletalova, Veronika and von Wirth, Timo}, title = {Beyond technology}, series = {Energy research \& social science}, volume = {89}, journal = {Energy research \& social science}, publisher = {Elsevier}, address = {Amsterdam}, issn = {22146296}, doi = {10.1016/j.erss.2022.102536}, pages = {11}, year = {2022}, abstract = {This article enriches the existing literature on the importance and role of the social sciences and humanities (SSH) in renewable energy sources research by providing a novel approach to instigating the future research agenda in this field. Employing a series of in-depth interviews, deliberative focus group workshops and a systematic horizon scanning process, which utilised the expert knowledge of 85 researchers from the field with diverse disciplinary backgrounds and expertise, the paper develops a set of 100 priority questions for future research within SSH scholarship on renewable energy sources. These questions were aggregated into four main directions: (i) deep transformations and connections to the broader economic system (i.e. radical ways of (re)arranging socio-technical, political and economic relations), (ii) cultural and geographical diversity (i.e. contextual cultural, historical, political and socio-economic factors influencing citizen support for energy transitions), (iii) complexifying energy governance (i.e. understanding energy systems from a systems dynamics perspective) and (iv) shifting from instrumental acceptance to value-based objectives (i.e. public support for energy transitions as a normative notion linked to trust-building and citizen engagement). While this agenda is not intended to be—and cannot be—exhaustive or exclusive, we argue that it advances the understanding of SSH research on renewable energy sources and may have important value in the prioritisation of SSH themes needed to enrich dialogues between policymakers, funding institutions and researchers. SSH scholarship should not be treated as instrumental to other research on renewable energy but as intrinsic and of the same hierarchical importance.}, language = {en} } @article{HerreroThorntonMasonD'Crozetal.2020, author = {Herrero, Mario and Thornton, Philip K. and Mason-D'Croz, Daniel and Palmer, Jeda and Bodirsky, Benjamin Leon and Pradhan, Prajal and Barrett, Christopher B. and Benton, Tim G. and Hall, Andrew and Pikaar, Ilje and Bogard, Jessica R. and Bonnett, Graham D. and Bryan, Brett A. and Campbell, Bruce M. and Christensen, Svend and Clark, Michael and Fanzo, Jessica and Godde, Cecile M. and Jarvis, Andy and Loboguerrero, Ana Maria and Mathys, Alexander and McIntyre, C. Lynne and Naylor, Rosamond L. and Nelson, Rebecca and Obersteiner, Michael and Parodi, Alejandro and Popp, Alexander and Ricketts, Katie and Smith, Pete and Valin, Hugo and Vermeulen, Sonja J. and Vervoort, Joost and van Wijk, Mark and van Zanten, Hannah H. E. and West, Paul C. and Wood, Stephen A. and Rockstr{\"o}m, Johan}, title = {Articulating the effect of food systems innovation on the Sustainable Development Goals}, series = {The lancet Planetary health}, volume = {5}, journal = {The lancet Planetary health}, number = {1}, publisher = {Elsevier}, address = {Oxford}, issn = {2542-5196}, doi = {10.1016/S2542-5196(20)30277-1}, pages = {E50 -- E62}, year = {2020}, abstract = {Food system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level.}, language = {en} } @article{MarquerGaillardSugitaetal.2017, author = {Marquer, Laurent and Gaillard, Marie-Jose and Sugita, Shinya and Poska, Anneli and Trondman, Anna-Kari and Mazier, Florence and Nielsen, Anne Birgitte and Fyfe, Ralph M. and Jonsson, Anna Maria and Smith, Benjamin and Kaplan, Jed O. and Alenius, Teija and Birks, H. John B. and Bjune, Anne E. and Christiansen, Jorg and Dodson, John and Edwards, Kevin J. and Giesecke, Thomas and Herzschuh, Ulrike and Kangur, Mihkel and Koff, Tiiu and Latalowa, Maligorzata and Lechterbeck, Jutta and Olofsson, Jorgen and Seppa, Heikki}, title = {Quantifying the effects of land use and climate on Holocene vegetation in Europe}, series = {Quaternary science reviews : the international multidisciplinary research and review journal}, volume = {171}, journal = {Quaternary science reviews : the international multidisciplinary research and review journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0277-3791}, doi = {10.1016/j.quascirev.2017.07.001}, pages = {20 -- 37}, year = {2017}, abstract = {Early agriculture can be detected in palaeovegetation records, but quantification of the relative importance of climate and land use in influencing regional vegetation composition since the onset of agriculture is a topic that is rarely addressed. We present a novel approach that combines pollen-based REVEALS estimates of plant cover with climate, anthropogenic land-cover and dynamic vegetation modelling results. This is used to quantify the relative impacts of land use and climate on Holocene vegetation at a sub-continental scale, i.e. northern and western Europe north of the Alps. We use redundancy analysis and variation partitioning to quantify the percentage of variation in vegetation composition explained by the climate and land-use variables, and Monte Carlo permutation tests to assess the statistical significance of each variable. We further use a similarity index to combine pollen based REVEALS estimates with climate-driven dynamic vegetation modelling results. The overall results indicate that climate is the major driver of vegetation when the Holocene is considered as a whole and at the sub-continental scale, although land use is important regionally. Four critical phases of land-use effects on vegetation are identified. The first phase (from 7000 to 6500 BP) corresponds to the early impacts on vegetation of farming and Neolithic forest clearance and to the dominance of climate as a driver of vegetation change. During the second phase (from 4500 to 4000 BP), land use becomes a major control of vegetation. Climate is still the principal driver, although its influence decreases gradually. The third phase (from 2000 to 1500 BP) is characterised by the continued role of climate on vegetation as a consequence of late-Holocene climate shifts and specific climate events that influence vegetation as well as land use. The last phase (from 500 to 350 BP) shows an acceleration of vegetation changes, in particular during the last century, caused by new farming practices and forestry in response to population growth and industrialization. This is a unique signature of anthropogenic impact within the Holocene but European vegetation remains climatically sensitive and thus may continue to respond to ongoing climate change. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} } @article{SaikinJordanovaZhangetal.2018, author = {Saikin, Anthony and Jordanova, Vania K. and Zhang, J. C. and Smith, C. W. and Spence, H. E. and Larsen, B. A. and Reeves, G. D. and Torbert, R. B. and Kletzing, C. A. and Zhelayskaya, I. S. and Shprits, Yuri Y.}, title = {Comparing simulated and observed EMIC wave amplitudes using in situ Van}, series = {Journal of Atmospheric and Solar-Terrestrial Physics}, volume = {177}, journal = {Journal of Atmospheric and Solar-Terrestrial Physics}, publisher = {Elsevier}, address = {Oxford}, issn = {1364-6826}, doi = {10.1016/j.jastp.2018.01.024}, pages = {190 -- 201}, year = {2018}, abstract = {We perform a statistical study calculating electromagnetic ion cyclotron (EMIC) wave amplitudes based off in situ plasma measurements taken by the Van Allen Probes' (1.1-5.8 Re) Helium, Oxygen, Proton, Electron (HOPE) instrument. Calculated wave amplitudes are compared to EMIC waves observed by the Electric and Magnetic Field Instrument Suite and Integrated Science on board the Van Allen Probes during the same period. The survey covers a 22-month period (1 November 2012 to 31 August 2014), a full Van Allen Probe magnetic local time (MLT) precession. The linear theory proxy was used to identify EMIC wave events with plasma conditions favorable for EMIC wave excitation. Two hundred and thirty-two EMIC wave events (103 H+-band and 129 He+-band) were selected for this comparison. Nearly all events selected are observed beyond L = 4. Results show that calculated wave amplitudes exclusively using the in situ HOPE measurements produce amplitudes too low compared to the observed EMIC wave amplitudes. Hot proton anisotropy (Ahp) distributions are asymmetric in MLT within the inner (L < 7) magnetosphere with peak (minimum) Ahp, ∼0.81 to 1.00 (∼0.62), observed in the dawn (dusk), 0000 < MLT ≤ 1200 (1200 < MLT ≤ 2400), sectors. Measurements of Ahp are found to decrease in the presence of EMIC wave activity. Ahp amplification factors are determined and vary with respect to EMIC wave-band and MLT. He+-band events generally require double (quadruple) the measured Ahp for the dawn (dusk) sector to reproduce the observed EMIC wave amplitudes.}, language = {en} }