@article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @article{AckermannAjelloAllafortetal.2011, author = {Ackermann, Margit and Ajello, M. and Allafort, A. J. and Baldini, L. and Ballet, J. and Barbiellini, G. and Bastieri, D. and Belfiore, A. and Bellazzini, R. and Berenji, B. and Blandford, R. D. and Bloom, E. D. and Bonamente, E. and Borgland, A. W. and Bottacini, E. and Brigida, M. and Bruel, P. and Buehler, R. and Buson, S. and Caliandro, G. A. and Cameron, R. A. and Caraveo, P. A. and Casandjian, J. M. and Cecchi, C. and Chekhtman, A. and Cheung, C. C. and Chiang, J. and Ciprini, S. and Claus, R. and Cohen-Tanugi, J. and de Angelis, A. and de Palma, F. and Dermer, C. D. and do Couto e Silva, E. and Drell, P. S. and Dumora, D. and Favuzzi, C. and Fegan, S. J. and Focke, W. B. and Fortin, P. and Fukazawa, Y. and Fusco, P. and Gargano, F. and Germani, S. and Giglietto, N. and Giordano, F. and Giroletti, M. and Glanzman, T. and Godfrey, G. and Grenier, I. A. and Guillemot, L. and Guiriec, S. and Hadasch, D. and Hanabata, Y. and Harding, A. K. and Hayashida, M. and Hayashi, K. and Hays, E. and Johannesson, G. and Johnson, A. S. and Kamae, T. and Katagiri, H. and Kataoka, J. and Kerr, M. and Knoedlseder, J. and Kuss, M. and Lande, J. and Latronico, L. and Lee, S. -H. and Longo, F. and Loparco, F. and Lott, B. and Lovellette, M. N. and Lubrano, P. and Martin, P. and Mazziotta, Mario Nicola and McEnery, J. E. and Mehault, J. and Michelson, P. F. and Mitthumsiri, W. and Mizuno, T. and Monte, C. and Monzani, M. E. and Morselli, A. and Moskalenko, I. V. and Murgia, S. and Naumann-Godo, M. and Nolan, P. L. and Norris, J. P. and Nuss, E. and Ohsugi, T. and Okumura, A. and Orlando, E. and Ormes, J. F. and Ozaki, M. and Paneque, D. and Parent, D. and Pesce-Rollins, M. and Pierbattista, M. and Piron, F. and Pohl, Martin and Prokhorov, D. and Raino, S. and Rando, R. and Razzano, M. and Reposeur, T. and Ritz, S. and Parkinson, P. M. Saz and Sgro, C. and Siskind, E. J. and Smith, P. D. and Spinelli, P. and Strong, A. W. and Takahashi, H. and Tanaka, T. and Thayer, J. G. and Thayer, J. B. and Thompson, D. J. and Tibaldo, L. and Torres, D. F. and Tosti, G. and Tramacere, A. and Troja, E. and Uchiyama, Y. and Vandenbroucke, J. and Vasileiou, V. and Vianello, G. and Vitale, V. and Waite, A. P. and Wang, P. and Winer, B. L. and Wood, K. S. and Yang, Z. and Zimmer, S. and Bontemps, S.}, title = {A cocoon of freshly accelerated cosmic rays detected by fermi in the cygnus superbubble}, series = {Science}, volume = {334}, journal = {Science}, number = {6059}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.1210311}, pages = {1103 -- 1107}, year = {2011}, abstract = {The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.}, language = {en} } @article{vanderValkKreinerMollerKooijmanetal.2015, author = {van der Valk, Ralf J. P. and Kreiner-Moller, Eskil and Kooijman, Marjolein N. and Guxens, Monica and Stergiakouli, Evangelia and Saaf, Annika and Bradfield, Jonathan P. and Geller, Frank and Hayes, M. Geoffrey and Cousminer, Diana L. and Koerner, Antje and Thiering, Elisabeth and Curtin, John A. and Myhre, Ronny and Huikari, Ville and Joro, Raimo and Kerkhof, Marjan and Warrington, Nicole M. and Pitkanen, Niina and Ntalla, Ioanna and Horikoshi, Momoko and Veijola, Riitta and Freathy, Rachel M. and Teo, Yik-Ying and Barton, Sheila J. and Evans, David M. and Kemp, John P. and St Pourcain, Beate and Ring, Susan M. and Smith, George Davey and Bergstrom, Anna and Kull, Inger and Hakonarson, Hakon and Mentch, Frank D. and Bisgaard, Hans and Chawes, Bo Lund Krogsgaard and Stokholm, Jakob and Waage, Johannes and Eriksen, Patrick and Sevelsted, Astrid and Melbye, Mads and van Duijn, Cornelia M. and Medina-Gomez, Carolina and Hofman, Albert and de Jongste, Johan C. and Taal, H. Rob and Uitterlinden, Andre G. and Armstrong, Loren L. and Eriksson, Johan and Palotie, Aarno and Bustamante, Mariona and Estivill, Xavier and Gonzalez, Juan R. and Llop, Sabrina and Kiess, Wieland and Mahajan, Anubha and Flexeder, Claudia and Tiesler, Carla M. T. and Murray, Clare S. and Simpson, Angela and Magnus, Per and Sengpiel, Verena and Hartikainen, Anna-Liisa and Keinanen-Kiukaanniemi, Sirkka and Lewin, Alexandra and Alves, Alexessander Da Silva Couto and Blakemore, Alexandra I. F. and Buxton, Jessica L. and Kaakinen, Marika and Rodriguez, Alina and Sebert, Sylvain and Vaarasmaki, Marja and Lakka, Timo and Lindi, Virpi and Gehring, Ulrike and Postma, Dirkje S. and Ang, Wei and Newnham, John P. and Lyytikainen, Leo-Pekka and Pahkala, Katja and Raitakari, Olli T. and Panoutsopoulou, Kalliope and Zeggini, Eleftheria and Boomsma, Dorret I. and Groen-Blokhuis, Maria and Ilonen, Jorma and Franke, Lude and Hirschhorn, Joel N. and Pers, Tune H. and Liang, Liming and Huang, Jinyan and Hocher, Berthold and Knip, Mikael and Saw, Seang-Mei and Holloway, John W. and Melen, Erik and Grant, Struan F. A. and Feenstra, Bjarke and Lowe, William L. and Widen, Elisabeth and Sergeyev, Elena and Grallert, Harald and Custovic, Adnan and Jacobsson, Bo and Jarvelin, Marjo-Riitta and Atalay, Mustafa and Koppelman, Gerard H. and Pennell, Craig E. and Niinikoski, Harri and Dedoussis, George V. and Mccarthy, Mark I. and Frayling, Timothy M. and Sunyer, Jordi and Timpson, Nicholas J. and Rivadeneira, Fernando and Bonnelykke, Klaus and Jaddoe, Vincent W. V.}, title = {A novel common variant in DCST2 is associated with length in early life and height in adulthood}, series = {Human molecular genetics}, volume = {24}, journal = {Human molecular genetics}, number = {4}, publisher = {Oxford Univ. Press}, address = {Oxford}, organization = {Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG}, issn = {0964-6906}, doi = {10.1093/hmg/ddu510}, pages = {1155 -- 1168}, year = {2015}, abstract = {Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05\%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13\% of variance in birth length. The same SNPs explained 2.95\% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.}, language = {en} } @article{AliuArchambaultAuneetal.2014, author = {Aliu, E. and Archambault, S. and Aune, T. and Benbow, W. and Berger, K. and Bird, R. and Bouvier, A. and Buckley, J. H. and Bugaev, V. and Byrum, K. and Cerruti, M. and Chen, Xuhui and Ciupik, L. and Connolly, M. P. and Cui, W. and Dumm, J. and Errando, M. and Falcone, A. and Federici, Simone and Feng, Q. and Finley, J. P. and Fortin, P. and Fortson, L. and Furniss, A. and Galante, N. and Gillanders, G. H. and Griffin, S. and Griffiths, S. T. and Grube, J. and Gyuk, G. and Hanna, D. and Holder, J. and Hughes, G. and Humensky, T. B. and Kaaret, P. and Kertzman, M. and Khassen, Y. and Kieda, D. and Krennrich, F. and Kumar, S. and Lang, M. J. and Lyutikov, M. and Maier, G. and McArthur, S. and McCann, A. and Meagher, K. and Millis, J. and Moriarty, P. and Mukherjee, R. and Ong, R. A. and Otte, A. N. and Park, N. and Perkins, J. S. and Pohl, M. and Popkow, A. and Quinn, J. and Ragan, K. and Rajotte, J. and Reyes, L. C. and Reynolds, P. T. and Richards, G. T. and Roache, E. and Sembroski, G. H. and Sheidaei, F. and Smith, A. W. and Staszak, D. and Telezhinsky, Igor O. and Theiling, M. and Tucci, J. V. and Tyler, J. and Varlotta, A. and Wakely, S. P. and Weekes, T. C. and Weinstein, A. and Welsing, R. and Williams, D. A. and Zajczyk, A. and Zitzer, B.}, title = {A search for enhanced very high energy GAMMA-RAY emission from the 2013 march crab nebula flare}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, volume = {781}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2041-8205}, doi = {10.1088/2041-8205/781/1/L11}, pages = {7}, year = {2014}, abstract = {In 2013 March, a flaring episode from the Crab Nebula lasting similar to 2 weeks was detected by Fermi-LAT (Large Area Telescope on board the Fermi Gamma-ray Space Telescope). The Very Energetic Radiation Imaging Telescope Array System (VERITAS) provides simultaneous observations throughout this period. During the flare, Fermi-LAT detected a 20 fold increase in flux above the average synchrotron flux >100 MeV seen from the Crab Nebula. Simultaneous measurements with VERITAS are consistent with the non-variable long-term average Crab Nebula flux at TeV energies. Assuming a linear correlation between the very high energy flux change >1 TeV and the flux change seen in the Fermi-LAT band >100 MeV during the period of simultaneous observations, the linear correlation factor can be constrained to be at most 8.6 x 10(-3) with 95\% confidence.}, language = {en} } @article{AliuArchambaultArcheretal.2015, author = {Aliu, E. and Archambault, S. and Archer, A. and Aune, T. and Barnacka, Anna and Beilicke, M. and Benbow, W. and Bird, R. and Buckley, J. H. and Bugaev, V. and Byrum, K. and Cardenzana, J. V. and Cerruti, M. and Chen, Xuhui and Ciupik, L. and Connolly, M. P. and Cui, W. and Dickinson, H. J. and Dumm, J. and Eisch, J. D. and Errando, M. and Falcone, A. and Feng, Q. and Finley, J. P. and Fleischhack, H. and Fortin, P. and Fortson, L. and Furniss, A. and Gillanders, G. H. and Griffin, S. and Griffiths, S. T. and Grube, J. and Gyuk, G. and Kansson, N. H. A. and Hanna, D. and Holder, J. and Humensky, T. B. and Johnson, C. A. and Kaaret, P. and Kar, P. and Kertzman, M. and Kieda, D. and Krennrich, F. and Kumar, S. and Lang, M. J. and Lyutikov, M. and Madhavan, A. S. and Maier, G. and McArthur, S. and McCann, A. and Meagher, K. and Millis, J. and Moriarty, P. and Mukherjee, R. and Nieto, D. and Ong, R. A. and Otte, A. N. and Park, N. and Pohl, Manuela and Popkow, A. and Prokoph, H. and Pueschel, Elisa and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Richards, G. T. and Roache, E. and Santander, M. and Sembroski, G. H. and Shahinyan, K. and Smith, A. W. and Staszak, D. and Telezhinsky, Igor O. and Tucci, J. V. and Tyler, J. and Varlotta, A. and Vincent, S. and Wakely, S. P. and Weinstein, A. and Williams, D. A. and Zajczyk, A. and Zitzer, B.}, title = {A search for pulsations from geminga above 100 GeV with veritas}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {800}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/800/1/61}, pages = {7}, year = {2015}, abstract = {We present the results of 71.6 hr of observations of the Geminga pulsar (PSR J0633+1746) with the VERITAS very-high-energy gamma-ray telescope array. Data taken with VERITAS between 2007 November and 2013 February were phase-folded using a Geminga pulsar timing solution derived from data recorded by the XMM-Newton and Fermi-LAT space telescopes. No significant pulsed emission above 100 GeV is observed, and we report upper limits at the 95\% confidence level on the integral flux above 135 GeV (spectral analysis threshold) of 4.0x10(-13) s(-1) cm(-2) and 1.7 x 10(-13) s(-1) cm(-2) for the two principal peaks in the emission profile. These upper limits, placed in context with phase-resolved spectral energy distributions determined from 5 yr of data from the Fermi-Large Area Telescope (LAT), constrain possible hardening of the Geminga pulsar emission spectra above similar to 50 GeV.}, language = {en} } @article{AliuArchambaultArcheretal.2016, author = {Aliu, E. and Archambault, S. and Archer, A. and Benbow, W. and Bird, R. and Biteau, Jonathan and Buchovecky, M. and Buckley, J. H. and Bugaev, V. and Byrum, K. and Cardenzana, J. V. and Cerruti, M. and Chen, Xuhui and Ciupik, L. and Connolly, M. P. and Cui, W. and Dickinson, H. J. and Eisch, J. D. and Falcone, A. and Feng, Q. and Finley, J. P. and Fleischhack, H. and Flinders, A. and Fortin, P. and Fortson, L. and Furniss, A. and Gillanders, G. H. and Griffin, S. and Grube, J. and Gyuk, G. and Huetten, M. and Hakansson, Nils and Holder, J. and Humensky, T. B. and Johnson, C. A. and Kaaret, P. and Kar, P. and Kelley-Hoskins, N. and Kertzman, M. and Kieda, D. and Krause, M. and Lang, M. J. and Loo, A. and Maier, G. and McArthur, S. and McCann, A. and Meagher, K. and Moriarty, P. and Mukherjee, R. and Nguyen, T. and Nieto, D. and Ong, R. A. and Otte, A. N. and Pandel, D. and Park, N. and Pelassa, V. and Petrashyk, A. and Pohl, M. and Popkow, A. and Pueschel, Elisa and Quinn, J. and Ragan, K. and Reynolds, P. T. and Richards, G. T. and Roache, E. and Rulten, C. and Santander, M. and Sembroski, G. H. and Shahinyan, K. and Smith, A. W. and Staszak, D. and Telezhinsky, Igor O. and Tucci, J. V. and Tyler, J. and Varlotta, A. and Vincent, S. and Wakely, S. P. and Weiner, O. M. and Weinstein, A. and Wilhelm, Alina and Williams, D. A. and Zitzer, B. and Chernyakova, M. and Roberts, M. S. E.}, title = {A SEARCH FOR VERY HIGH ENERGY GAMMA RAYS FROM THE MISSING LINK BINARY PULSAR J1023+0038 WITH VERITAS}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {831}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.3847/0004-637X/831/2/193}, pages = {7}, year = {2016}, abstract = {The binary millisecond radio pulsar PSR J1023+0038 exhibits many characteristics similar to the gamma-ray binary system PSR B1259-63/LS 2883, making it an ideal candidate for the study of high-energy nonthermal emission. It has been the subject of multiwavelength campaigns following the disappearance of the pulsed radio emission in 2013 June, which revealed the appearance of an accretion disk around the neutron star. We present the results of very high energy (VHE) gamma-ray observations carried out by the Very Energetic Radiation Imaging Telescope Array System before and after this change of state. Searches for steady and pulsed emission of both data sets yield no significant gamma-ray signal above 100 GeV, and upper limits are given for both a steady and pulsed gamma-ray flux. These upper limits are used to constrain the magnetic field strength in the shock region of the PSR J1023+0038 system. Assuming that VHE gamma rays are produced via an inverse Compton mechanism in the shock region, we constrain the shock magnetic field to be greater than similar to 2 G before the disappearance of the radio pulsar and greater than similar to 10 G afterward.}, language = {en} } @article{AliuArchambaultArlenetal.2014, author = {Aliu, E. and Archambault, S. and Arlen, T. and Aune, T. and Behera, B. and Beilicke, M. and Benbow, W. and Berger, K. and Bird, R. and Bouvier, A. and Buckley, J. H. and Bugaev, V. and Byrum, K. and Cerruti, M. and Chen, Xuhui and Ciupik, L. and Connolly, M. P. and Cui, W. and Duke, C. and Dumm, J. and Errando, M. and Falcone, A. and Federici, S. and Feng, Q. and Finley, J. P. and Fleischhack, H. and Fortin, P. and Fortson, L. and Furniss, A. and Galante, N. and Gillanders, G. H. and Griffin, S. and Griffiths, S. T. and Grube, J. and Gyuk, G. and Hanna, D. and Holder, J. and Hughes, G. and Humensky, T. B. and Johnson, C. A. and Kaaret, P. and Kertzman, M. and Khassen, Y. and Kieda, D. and Krawczynski, H. and Krennrich, F. and Lang, M. J. and Madhavan, A. S. and Maier, G. and Majumdar, P. and McArthur, S. and McCann, A. and Meagher, K. and Millis, J. and Moriarty, P. and Mukherjee, R. and Nieto, D. and Ong, R. A. and Otte, A. N. and Park, N. and Perkins, J. S. and Pohl, M. and Popkow, A. and Prokoph, H. and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Richards, G. T. and Roache, E. and Sembroski, G. H. and Smith, A. W. and Staszak, D. and Telezhinsky, Igor O. and Theiling, M. and Varlotta, A. and Vassiliev, V. V. and Vincent, S. and Wakely, S. P. and Weekes, T. C. and Weinstein, A. and Welsing, R. and Williams, D. A. and Zajczyk, A. and Zitzer, B.}, title = {A three-year multi-wavelenght study of the very-high-energy gamma-ray Blazar 1ES 0229+200}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {782}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/782/1/13}, pages = {12}, year = {2014}, language = {en} } @article{TownsleyBroosCorcoranetal.2011, author = {Townsley, Leisa K. and Broos, Patrick S. and Corcoran, Michael F. and Feigelson, Eric D. and Gagne, Marc and Montmerle, Thierry and Oey, M. S. and Smith, Nathan and Garmire, Gordon P. and Getman, Konstantin V. and Povich, Matthew S. and Evans, Nancy Remage and Naze, Yael and Parkin, E. R. and Preibisch, Thomas and Wang, Junfeng and Wou, Scott J. and Chu, You-Hua and Cohen, David H. and Gruendl, Robert A. and Hamaguchi, Kenji and King, Robert R. and Mac Low, Mordecai-Mark and McCaughrean, Mark J. and Moffat, Anthony F. J. and Oskinova, Lida and Pittard, Julian M. and Stassun, Keivan G. and Ud-Doula, Asif and Walborn, Nolan R. and Waldron, Wayne L. and Churchwell, Ed and Nictiols, J. S. and Owocki, Stanley P. and Schulz, Norbert S.}, title = {An introduction to the chandra carina complex project}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, volume = {194}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0067-0049}, doi = {10.1088/0067-0049/194/1/1}, pages = {28}, year = {2011}, abstract = {The Great Nebula in Carina provides an exceptional view into the violent massive star formation and feedback that typifies giant H II regions and starburst galaxies. We have mapped the Carina star-forming complex in X-rays, using archival Chandra data and a mosaic of 20 new 60 ks pointings using the Chandra X-ray Observatory's Advanced CCD Imaging Spectrometer, as a testbed for understanding recent and ongoing star formation and to probe Carina's regions of bright diffuse X-ray emission. This study has yielded a catalog of properties of > 14,000 X-ray point sources;> 9800 of them have multiwavelength counterparts. Using Chandra's unsurpassed X-ray spatial resolution, we have separated these point sources from the extensive, spatially-complex diffuse emission that pervades the region; X-ray properties of this diffuse emission suggest that it traces feedback from Carina's massive stars. In this introductory paper, we motivate the survey design, describe the Chandra observations, and present some simple results, providing a foundation for the 15 papers that follow in this special issue and that present detailed catalogs, methods, and science results.}, language = {en} } @article{KothariBattistiBooteetal.2022, author = {Kothari, Kritika and Battisti, Rafael and Boote, Kenneth J. and Archontoulis, Sotirios and Confalone, Adriana and Constantin, Julie and Cuadra, Santiago and Debaeke, Philippe and Faye, Babacar and Grant, Brian and Hoogenboom, Gerrit and Jing, Qi and van der Laan, Michael and Macena da Silva, Fernando Antonio and Marin, Fabio R. and Nehbandani, Alireza and Nendel, Claas and Purcell, Larry C. and Qian, Budong and Ruane, Alex C. and Schoving, Celine and Silva, Evandro H. F. M. and Smith, Ward and Soltani, Afshin and Srivastava, Amit and Vieira, Nilson A. and Slone, Stacey and Salmeron, Montserrat}, title = {Are soybean models ready for climate change food impact assessments?}, series = {European journal of agronomy : the official journal of the European Society for Agronomy}, volume = {135}, journal = {European journal of agronomy : the official journal of the European Society for Agronomy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1161-0301}, doi = {10.1016/j.eja.2022.126482}, pages = {15}, year = {2022}, abstract = {An accurate estimation of crop yield under climate change scenarios is essential to quantify our ability to feed a growing population and develop agronomic adaptations to meet future food demand. A coordinated evaluation of yield simulations from process-based eco-physiological models for climate change impact assessment is still missing for soybean, the most widely grown grain legume and the main source of protein in our food chain. In this first soybean multi-model study, we used ten prominent models capable of simulating soybean yield under varying temperature and atmospheric CO2 concentration [CO2] to quantify the uncertainty in soybean yield simulations in response to these factors. Models were first parametrized with high quality measured data from five contrasting environments. We found considerable variability among models in simulated yield responses to increasing temperature and [CO2]. For example, under a + 3 degrees C temperature rise in our coolest location in Argentina, some models simulated that yield would reduce as much as 24\%, while others simulated yield increases up to 29\%. In our warmest location in Brazil, the models simulated a yield reduction ranging from a 38\% decrease under + 3 degrees C temperature rise to no effect on yield. Similarly, when increasing [CO2] from 360 to 540 ppm, the models simulated a yield increase that ranged from 6\% to 31\%. Model calibration did not reduce variability across models but had an unexpected effect on modifying yield responses to temperature for some of the models. The high uncertainty in model responses indicates the limited applicability of individual models for climate change food projections. However, the ensemble mean of simulations across models was an effective tool to reduce the high uncertainty in soybean yield simulations associated with individual models and their parametrization. Ensemble mean yield responses to temperature and [CO2] were similar to those reported from the literature. Our study is the first demonstration of the benefits achieved from using an ensemble of grain legume models for climate change food projections, and highlights that further soybean model development with experiments under elevated [CO2] and temperature is needed to reduce the uncertainty from the individual models.}, language = {en} } @article{HerreroThorntonMasonD'Crozetal.2020, author = {Herrero, Mario and Thornton, Philip K. and Mason-D'Croz, Daniel and Palmer, Jeda and Bodirsky, Benjamin Leon and Pradhan, Prajal and Barrett, Christopher B. and Benton, Tim G. and Hall, Andrew and Pikaar, Ilje and Bogard, Jessica R. and Bonnett, Graham D. and Bryan, Brett A. and Campbell, Bruce M. and Christensen, Svend and Clark, Michael and Fanzo, Jessica and Godde, Cecile M. and Jarvis, Andy and Loboguerrero, Ana Maria and Mathys, Alexander and McIntyre, C. Lynne and Naylor, Rosamond L. and Nelson, Rebecca and Obersteiner, Michael and Parodi, Alejandro and Popp, Alexander and Ricketts, Katie and Smith, Pete and Valin, Hugo and Vermeulen, Sonja J. and Vervoort, Joost and van Wijk, Mark and van Zanten, Hannah H. E. and West, Paul C. and Wood, Stephen A. and Rockstr{\"o}m, Johan}, title = {Articulating the effect of food systems innovation on the Sustainable Development Goals}, series = {The lancet Planetary health}, volume = {5}, journal = {The lancet Planetary health}, number = {1}, publisher = {Elsevier}, address = {Oxford}, issn = {2542-5196}, doi = {10.1016/S2542-5196(20)30277-1}, pages = {E50 -- E62}, year = {2020}, abstract = {Food system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level.}, language = {en} }