@article{SchuchStubbsMeyeretal.2019,
  author    = {Schuch, Felipe B. and Stubbs, Brendon and Meyer, Jacob and Heissel, Andreas and Zech, Philipp and Vancampfort, Davy and Rosenbaum, Simon and Deenik, Jeroen and Firth, Joseph and Ward, Philip B. and Carvalho, Andre F. and Hiles, Sarah A.},
  title     = {Physical activity protects from incident anxiety: A meta-analysis of prospective cohort studies},
  series = {Depression and anxiety},
  volume    = {36},
  journal   = {Depression and anxiety},
  number    = {9},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1091-4269},
  doi       = {10.1002/da.22915},
  pages     = {846 -- 858},
  year      = {2019},
  abstract  = {Background Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta-analysis has been conducted. Aims To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow-up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted and heterogeneity was explored using subgroup and meta-regression analysis. Results Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1\%) followed for 357,424 person-years, people with high self-reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95\% confidence level [95\% CI] = 0.62, 0.88; crude OR = 0.80; 95\% CI = 0.69, 0.92). High self-reported PA was protective against the emergence of agoraphobia (AOR = 0.42; 95\% CI = 0.18, 0.98) and posttraumatic stress disorder (AOR = 0.57; 95\% CI = 0.39, 0.85). The protective effects for anxiety were evident in Asia (AOR = 0.31; 95\% CI = 0.10, 0.96) and Europe (AOR = 0.82; 95\% CI = 0.69, 0.97); for children/adolescents (AOR = 0.52; 95\% CI = 0.29, 0.90) and adults (AOR = 0.81; 95\% CI = 0.69, 0.95). Results remained robust when adjusting for confounding factors. Overall study quality was moderate to high (mean NOS = 6.7 out of 9). Conclusion Evidence supports the notion that self-reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.},
  language  = {en}
}
@article{WessigGerngrossPapeetal.2014,
  author    = {Wessig, Pablo and Gerngroß, Maik and Pape, Simon and Bruhns, Philipp and Weber, Jens},
  title     = {Novel porous materials based on oligospiroketals (OSK)},
  series = {RSC Advances : an international journal to further the chemical sciences},
  volume    = {2014},
  journal   = {RSC Advances : an international journal to further the chemical sciences},
  number    = {4},
  issn      = {2046-2069},
  doi       = {10.1039/c4ra04437a},
  pages     = {31123 -- 31129},
  year      = {2014},
  abstract  = {New porous materials based on covalently connected monomers are presented. The key step of the synthesis is an acetalisation reaction. In previous years we used acetalisation reactions extensively to build up various molecular rods. Based on this approach, investigations towards porous polymeric materials were conducted by us. Here we wish to present the results of these studies in the synthesis of 1D polyacetals and porous 3D polyacetals. By scrambling experiments with 1D acetals we could prove that exchange reactions occur between different building blocks (evidenced by MALDI-TOF mass spectrometry). Based on these results we synthesized porous 3D polyacetals under the same mild conditions.},
  language  = {en}
}
@misc{WessigGerngrossPapeetal.2014,
  author    = {Wessig, Pablo and Gerngroß, Maik and Pape, Simon and Bruhns, Philipp and Weber, Jens},
  title     = {Novel porous materials based on oligospiroketals (OSK)},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-74466},
  pages     = {31123 -- 31129},
  year      = {2014},
  abstract  = {New porous materials based on covalently connected monomers are presented. The key step of the synthesis is an acetalisation reaction. In previous years we used acetalisation reactions extensively to build up various molecular rods. Based on this approach, investigations towards porous polymeric materials were conducted by us. Here we wish to present the results of these studies in the synthesis of 1D polyacetals and porous 3D polyacetals. By scrambling experiments with 1D acetals we could prove that exchange reactions occur between different building blocks (evidenced by MALDI-TOF mass spectrometry). Based on these results we synthesized porous 3D polyacetals under the same mild conditions.},
  language  = {en}
}
@article{EigmuellerChaushevGillenetal.2019,
  author    = {Eigm{\"u}ller, Philipp and Chaushev, Alexander and Gillen, Edward and Smith, Alexis and Nielsen, Louise D. and Turner, Oliver and Csizmadia, Szilard and Smalley, Barry and Bayliss, Daniel and Belardi, Claudia and Bouchy, Francois and Burleigh, Matthew R. and Cabrera, Juan and Casewell, Sarah L. and Chazelas, Bruno and Cooke, Benjamin F. and Erikson, Anders and Gansicke, Boris T. and Guenther, Maximilian N. and Goad, Michael R. and Grange, Andrew and Jackman, James A. G. and Jenkins, James S. and McCormac, James and Moyano, Maximiliano and Pollacco, Don and Poppenh{\"a}ger, Katja and Queloz, Didier and Raynard, Liam and Rauer, Heike and Udry, Stephane and Walker, Simon. R. and Watson, Christopher A. and West, Richard G. and Wheatley, Peter J.},
  title     = {NGTS-5b},
  series = {Astronomy and astrophysics : an international weekly journal},
  volume    = {625},
  journal   = {Astronomy and astrophysics : an international weekly journal},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  issn      = {1432-0746},
  doi       = {10.1051/0004-6361/201935206},
  pages     = {9},
  year      = {2019},
  abstract  = {Context. Planetary population analysis gives us insight into formation and evolution processes. For short-period planets, the sub-Jovian desert has been discussed in recent years with regard to the planet population in the mass/period and radius/period parameter space without taking stellar parameters into account. The Next Generation Transit Survey (NGTS) is optimised for detecting planets in this regime, which allows for further analysis of the sub-Jovian desert. Aims. With high-precision photometric surveys (e.g. with NGTS and TESS), which aim to detect short period planets especially around M/K-type host stars, stellar parameters need to be accounted for when empirical data are compared to model predictions. Presenting a newly discovered planet at the boundary of the sub-Jovian desert, we analyse its bulk properties and use it to show the properties of exoplanets that border the sub-Jovian desert. Methods. Using NGTS light curve and spectroscopic follow-up observations, we confirm the planetary nature of planet NGTS-5b and determine its mass. Using exoplanet archives, we set the planet in context with other discoveries. Results. NGTS-5b is a short-period planet with an orbital period of 3.3569866 +/- 0.0000026 days. With a mass of 0.229 +/- 0.037 M-Jup and a radius of 1.136 +/- 0.023 R-Jup, it is highly inflated. Its mass places it at the upper boundary of the sub-Jovian desert. Because the host is a K2 dwarf, we need to account for the stellar parameters when NGTS-5b is analysed with regard to planet populations. Conclusions. With red-sensitive surveys (e.g. with NGTS and TESS), we expect many more planets around late-type stars to be detected. An empirical analysis of the sub-Jovian desert should therefore take stellar parameters into account.},
  language  = {en}
}
@article{WessigGerngrossPapeetal.2014,
  author    = {Wessig, Pablo and Gerngross, Maik and Pape, Simon and Bruhns, Philipp and Weber, Jens},
  title     = {Novel porous materials based on oligospiroketals (OSK)},
  series = {RSC Advances},
  volume    = {4},
  journal   = {RSC Advances},
  number    = {59},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2046-2069},
  doi       = {10.1039/c4ra04437a},
  pages     = {31123 -- 31129},
  year      = {2014},
  abstract  = {New porous materials based on covalently connected monomers are presented. The key step of the synthesis is an acetalisation reaction. In previous years we used acetalisation reactions extensively to build up various molecular rods. Based on this approach, investigations towards porous polymeric materials were conducted by us. Here we wish to present the results of these studies in the synthesis of 1D polyacetals and porous 3D polyacetals. By scrambling experiments with 1D acetals we could prove that exchange reactions occur between different building blocks (evidenced by MALDI-TOF mass spectrometry). Based on these results we synthesized porous 3D polyacetals under the same mild conditions.},
  language  = {en}
}
@article{VukicevicSchwadtkeSchmueckeretal.2012,
  author    = {Vukicevic, Radovan and Schwadtke, Ulrike and Schmuecker, Simon and Schaefer, Philipp and Kuckling, Dirk and Beuermann, Sabine},
  title     = {Alkyne-azide coupling of tailored poly(vinylidene fluoride) and polystyrene for the synthesis of block copolymers},
  series = {Polymer Chemistry},
  volume    = {3},
  journal   = {Polymer Chemistry},
  number    = {2},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1759-9954},
  doi       = {10.1039/c1py00427a},
  pages     = {409 -- 414},
  year      = {2012},
  abstract  = {The synthesis of block copolymers consisting of poly(vinylidene fluoride) (PVDF) and polystyrene (PS) is reported. Firstly, a propargyl-functionalized alkoxyamine initiator (PgOTIPNO) was prepared and subsequently used for the preparation of a propargyl-terminated PS homopolymer of different chain lengths with low dispersities via nitroxide-mediated radical polymerization. A tailored PVDF homopolymer with iodine end groups originating from iodine transfer polymerization was transformed to PVDF with azide end group. Then, alkyne-terminated PS with different molecular weights and azide-terminated PVDF were joined together via copper-catalyzed alkyne-azide coupling. The block copolymers were characterized using H-1-NMR, F-19-NMR, IR, SEC, and DSC.},
  language  = {en}
}
@misc{BreuerFrauHofetal.2013,
  author    = {Breuer, Marten and Frau, Robert and Hof, Christina and H{\"u}fner, Klaus and Massoud, Sofia and Menger, Philipp and Mohsen, Sarah and Neumann, Simon and Petersen, Niels and Schniederjahn, Nina and Sp{\"a}tlich, Anja},
  title     = {MenschenRechtsMagazin : Informationen | Meinungen | Analysen},
  volume    = {13},
  number    = {1},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1434-2820},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-65358},
  year      = {2013},
  abstract  = {Aus dem Inhalt: - Die Umsetzung der Europ{\"a}ischen Menschenrechtskonvention in der deutschen Rechtsordnung - Ein neues Mind-set der Europ{\"a}ischen Grenzschutzagentur? Zur Internalisierung menschenrechtlicher Vorgaben durch Frontex - Menschenw{\"u}rde und Freiheitsentzug - Die T{\"a}tigkeit der Nationalen Stelle zur Verh{\"u}tung von Folter},
  language  = {de}
}
@article{vanLoonBaileyTattonetal.2013,
  author    = {van Loon, Jacco Th. and Bailey, M. and Tatton, B. L. and Apellaniz, Jesus Maiz and Crowther, P. A. and de Koter, A. and Evans, C. J. and Henault-Brunet, V. and Howarth, I. D. and Richter, Philipp and Sana, Hugues and Simon D{\´i}az, Sergio and Taylor, W. and Walborn, N. R.},
  title     = {The VLT-FLAMES tarantula survey IX. - the interstellar medium seen through diffuse interstellar bands and neutral sodium},
  series = {Astronomy and astrophysics : an international weekly journal},
  volume    = {550},
  journal   = {Astronomy and astrophysics : an international weekly journal},
  number    = {9},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  issn      = {0004-6361},
  doi       = {10.1051/0004-6361/201220210},
  pages     = {21},
  year      = {2013},
  abstract  = {Context. The Tarantula Nebula (a.k.a. 30 Dor) is a spectacular star-forming region in the Large Magellanic Cloud (LMC), seen through gas in the Galactic disc and halo. Diffuse interstellar bands (DIBs) offer a unique probe of the diffuse, cool-warm gas in these regions. Aims. The aim is to use DIBs as diagnostics of the local interstellar conditions, whilst at the same time deriving properties of the yet-unknown carriers of these enigmatic spectral features. Methods. Spectra of over 800 early-type stars from the Very Large Telescope Flames Tarantula Survey (VFTS) were analysed. Maps were created, separately, for the Galactic and LMC absorption in the DIBs at 4428 and 6614 angstrom and - in a smaller region near the central cluster R 136 - neutral sodium (the Na ID doublet); we also measured the DIBs at 5780 and 5797 angstrom. Results. The maps show strong 4428 and 6614 angstrom DIBs in the quiescent cloud complex to the south of 30 Dor but weak absorption in the harsher environments to the north (bubbles) and near the OB associations. The Na maps show at least five kinematic components in the LMC and a shell-like structure surrounding R 136, and small-scale structure in the Milky Way. The strengths of the 4428, 5780, 5797 and 6614 angstrom DIBs are correlated, also with Na absorption and visual extinction. The strong 4428 angstrom DIB is present already at low Na column density but the 6614, 5780 and 5797 angstrom DIBs start to be detectable at subsequently larger Na column densities. Conclusions. The carriers of the 4428, 6614, 5780 and 5797 angstrom DIBs are increasingly prone to removal from irradiated gas. The relative strength of the 5780 and 5797 angstrom DIBs clearly confirm the Tarantula Nebula as well as Galactic high-latitude gas to represent a harsh radiation environment. The resilience of the 4428 angstrom DIB suggests its carrier is large, compact and neutral. Structure is detected in the distribution of cool-warm gas on scales between one and > 100 pc in the LMC and as little as 0.01 pc in the Sun's vicinity. Stellar winds from the central cluster R 136 have created an expanding shell; some infalling gas is also detected, reminiscent of a galactic "fountain".},
  language  = {en}
}
@article{BusseSimonPetroffetal.2022,
  author    = {Busse, David and Simon, Philipp and Petroff, David and El-Najjar, Nahed and Schmitt, Lisa and Bindellini, Davide and Dietrich, Arne and Zeitlinger, Markus and Huisinga, Wilhelm and Michelet, Robin and Wrigge, Hermann and Kloft, Charlotte},
  title     = {High-dosage fosfomycin results in adequate plasma and target-site exposure in morbidly obese and nonobese nonhyperfiltration patients},
  series = {Antimicrobial agents and chemotherapy},
  volume    = {66},
  journal   = {Antimicrobial agents and chemotherapy},
  number    = {6},
  publisher = {American Society for Microbiology},
  address   = {Washington},
  issn      = {0066-4804},
  doi       = {10.1128/aac.02302-21},
  pages     = {12},
  year      = {2022},
  abstract  = {The objectives of this study were the identification in (morbidly) obese and nonobese patients of (i) the most appropriate body size descriptor for fosfomycin dose adjustments and (ii) adequacy of the currently employed dosing regimens. Plasma and target site (interstitial fluid of subcutaneous adipose tissue) concentrations after fosfomycin administration (8 g) to 30 surgery patients (15 obese/15 nonobese) were obtained from a prospective clinical trial. After characterization of plasma and microdialysis-derived target site pharmacokinetics via population analysis, short-term infusions of fosfomycin 3 to 4 times daily were simulated. The adequacy of therapy was assessed by probability of pharmacokinetic/pharmacodynamic target attainment (PTA) analysis based on the unbound drug-related targets of an \%fT(>= MIC) (the fraction of time that unbound fosfomycin concentrations exceed the MIC during 24 h) of 70 and an fAUC(0-24h)/MIC (the area under the concentration-time curve from 0 to 24 h for the unbound fraction of fosfomycin relative to the MIC) of 40.8 to 83.3. Lean body weight, fat mass, and creatinine clearance calculated via adjusted body weight (ABW) (CLCRCG_ABW) of all patients (body mass index [BMI] = 20.1 to 52.0 kg/m(2)) explained a considerable proportion of between-patient pharmacokinetic variability (up to 31.0\% relative reduction). The steady-state unbound target site/plasma concentration ratio was 26.3\% lower in (morbidly) obese than nonobese patients. For infections with fosfomycin-susceptible pathogens (MIC <= 16 mg/L), intermittent "high-dosage" intravenous (i.v.) fosfomycin (8 g, three times daily) was sufficient to treat patients with a CLCRCG_ABW of,130 mL/min, irrespective of the pharmacokinetic/pharmacodynamic indices considered. For infections by Pseudomonas aeruginosa with a MIC of 32 mg/L, when the index fAUC0-24h/MIC is applied, fosfomycin might represent a promising treatment option in obese and nonobese patients, especially in combination therapy to complement beta-lactams, in which carbapenem-resistant P. aeruginosa is critical. In conclusion, fosfomycin showed excellent target site penetration in obese and nonobese patients. Dosing should be guided by renal function rather than obesity status.},
  language  = {en}
}