@article{FriessRochSeifertetal.2019,
  author    = {Friess, Fabian and Roch, Toralf and Seifert, Barbara and Lendlein, Andreas and Wischke, Christian},
  title     = {Phagocytosis of spherical and ellipsoidal micronetwork colloids from crosslinked poly(epsilon-caprolactone)},
  series = {International Journal of Pharmaceutics},
  volume    = {567},
  journal   = {International Journal of Pharmaceutics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0378-5173},
  doi       = {10.1016/j.ijpharm.2019.118461},
  pages     = {7},
  year      = {2019},
  abstract  = {The effect of non-spherical particle shapes on cellular uptake has been reported as a general design parameter to control cellular recognition of particulate drug carriers. Beside shape, also size and cell-particle ratio should mutually effect phagocytosis. Here, the capability to control cellular uptake of poly(epsilon-caprolactone) (PCL) based polymer micronetwork colloids (MNC), a carrier system that can be transferred to various shapes, is explored in vitro at test conditions allowing multiple cell-particle contacts. PCL-based MNC were synthesized as spheres with a diameter of similar to 6, similar to 10, and 13 mu m, loaded with a fluorescent dye by a specific technique of swelling, redispersion and drying, and transferred into different ellipsoidal shapes by a phantom stretching method. The boundaries of MNC deformability to prolate ellipsoid target shapes were systematically analyzed and found to be at an aspect ratio AR of similar to 4 as obtained by a phantom elongation epsilon(ph) of similar to 150\%. Uptake studies with a murine macrophages cell line showed shape dependency of phagocytosis for selected conditions when varying particle sizes (similar to 6 and 10 mu m),and shapes (epsilon(ph): 0, 75 or 150\%), cell-particle ratios (1:1, 1:2, 1:10, 1:50), and time points (1-24 h). For larger-sized MNC, there was no significant shape effect on phagocytosis as these particles may associate with more than one cell, thus increasing the possibility of phagocytosis by any of these cells. Accordingly, controlling shape effects on phagocytosis for carriers made from degradable polymers relevant for medical applications requires considering further parameters besides shape, such as kinetic aspects of the exposure and uptake by cells.},
  language  = {en}
}
@article{SchwabSeifertWatkoetal.2013,
  author    = {Schwab, Susanne and Seifert, Susanne and Watko, Petra and Obendrauf, Tanja and Trauntschnig, Mike and Gasteiger-Klicpera, Barbara},
  title     = {LARS : Ein differenziertes Sprach- und Lesef{\"o}rderprogramm bei Grundsch{\"u}lerInnen mit Deutsch als Erst- und Zweit-Sprache},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  number    = {6},
  editor    = {Fritzsche, Tom and Meyer, Corinna B. and Adelt, Anne and Roß, Jennifer},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1866-9085},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68544},
  pages     = {175 -- 182},
  year      = {2013},
  abstract  = {1 Theoretischer Hintergrund 2 Fragestellung 3 Untersuchungsmethode 4 Ergebnisse 5 Ausblick 6 Literatur},
  language  = {de}
}
@misc{ClahsenSiegmuellerPenkeetal.2013,
  author    = {Clahsen, Harald and Siegm{\"u}ller, Julia and Penke, Martina and Schr{\"o}der, Astrid and Hofmann, Janine and Holzgrefe-Lang, Julia and Skerra, Antje and Adani, Flavia and Gagarina, Natalʹja Vladimirovna and Schr{\"o}ter, Carolin and Frieg, Hendrike and Belke, Eva and Schwab, Susanne and Seifert, Susanne and Watko, Petra and Obendrauf, Tanja and Trauntschnig, Mike and Gasteiger-Klicpera, Barbara and Adelt, Anne and Hanne, Sandra and Burchert, Frank and Swietza, Romy and Doppelbauer, Lea and Dralle, Jenny and Purat, Patricia and Webersinke, Dorothea and Schwytay, Jeannine and Stadie, Nicole and Hoppe, Carina and Heide, Judith and Marusch, Tina and von der Malsburg, Titus Raban and Bastiaanse, Roelien and Schultheiss, Corinna and Nahrstaedt, Holger and Schauer, Thomas and Seidl, Rainer Ottis and Rath, Elisa},
  title     = {Spektrum Patholinguistik = Schwerpunktthema: Labyrinth Grammatik: Therapie von syntaktischen St{\"o}rungen bei Kindern und Erwachsenen},
  number    = {6},
  editor    = {Fritzsche, Tom and Meyer, Corinna B. and Adelt, Anne and Roß, Jennifer},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  organization    = {Verband f{\"u}r Patholinguistik e. V. (vpl)},
  isbn      = {978-3-86956-270-4},
  issn      = {1869-3822},
  doi       = {10.25932/publishup-6612},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-67659},
  year      = {2013},
  abstract  = {Das Herbsttreffen Patholinguistik wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Das 6. Herbsttreffen mit dem Schwerpunktthema "Labyrinth Grammatik: Therapie von syntaktischen St{\"o}rungen bei Kindern und Erwachsenen" fand am 17.11.2012 in Potsdam statt. Im vorliegenden Tagungsband finden sich alle Beitr{\"a}ge der Veranstaltung: die vier Hauptvortr{\"a}ge zum Schwerpunkthema, die Vortr{\"a}ge aus Praxis und Forschung von vier Patholinguistinnen in der Reihe Spektrum Patholinguistik sowie die Abstracts der Posterpr{\"a}sentation.},
  language  = {de}
}