@article{KarlowatzScharhagRahnenfuehreretal.2011, author = {Karlowatz, Ruth-Jessica and Scharhag, J{\"u}rgen and Rahnenfuehrer, J{\"o}rg and Schneider, Ulrich and Jakob, Ernst and Kindermann, Wilfried and Zang, Klaus Dieter}, title = {Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes}, series = {British journal of sports medicine : the journal of sport and exercise medicine}, volume = {45}, journal = {British journal of sports medicine : the journal of sport and exercise medicine}, number = {1}, publisher = {BMJ Publ. Group}, address = {London}, issn = {0306-3674}, doi = {10.1136/bjsm.2008.050567}, pages = {36 -- 41}, year = {2011}, abstract = {Background Athlete's heart as an adaptation to long-time and intensive endurance training can vary considerably between individuals. Genetic polymorphisms in the cardiological relevant insulin-like growth factor 1 (IGF1) signalling pathway seem to have an essential influence on the extent of physiological hypertrophy. Objective Analysis of polymorphisms in the genes of IGF1, IGF1 receptor (IGF1R) and the negative regulator of the cardiac IGF1 signalling pathway, myostatin (MSTN), and their relation to left ventricular mass (LVM) of endurance athletes. Methods In 110 elite endurance athletes or athletes with a high amount of endurance training (75 males and 35 females) and 27 male controls, which were examined by echocardiographic imaging methods and ergometric exercise-testing, the genotypes of a cytosine-adenine repeat polymorphism in the promoter region of the IGF1 gene and a G/A substitution at position 3174 in the IGF1R gene were determined. Additionally, a mutation screen of the MSTN gene was performed. Results The polymorphisms in the IGF1 and the IGF1R gene showed a significant relation to the LVM for male (IGF1: p=0.003; IGF1R: p=0.01), but not for female athletes. The same applies to a previously unnoticed polymorphism in the 1 intron of the MSTN gene, whose deletion allele (AAA -> AA) appears to increase the myostatic effect (p=0.015). Moreover, combinations of the polymorphisms showed significant synergistic effects on the LVM of the male athletes. Conclusions The authors' results argue for the importance of polymorphisms in the IGF1 signalling pathway in combination with MSTN on the variant degree of physiological hypertrophy of male athletes.}, language = {en} } @article{StedingSchneider2021, author = {Steding, Svenja and Schneider, Wilfried}, title = {Prognose des Schadstoffaustrags aus mehrphasigen DNAPL-Pools mittels semi-analytischem Berechnungsmodell}, series = {Grundwasser : Zeitschrift der Fachsektion Hydrogeologie in der Deutschen Gesellschaft f{\"u}r Geowissenschaften (FH-DGG)}, volume = {26}, journal = {Grundwasser : Zeitschrift der Fachsektion Hydrogeologie in der Deutschen Gesellschaft f{\"u}r Geowissenschaften (FH-DGG)}, number = {3}, publisher = {Springer}, address = {Berlin ; Heidelberg}, issn = {1430-483X}, doi = {10.1007/s00767-021-00490-2}, pages = {241 -- 253}, year = {2021}, abstract = {Multicomponent DNAPL pools are among the most common reasons for groundwater contamination and represent highly persistent source areas. Although several studies have already shown that their constituents influence each other's solubility, existing models neglect these interactions. For this reason, a semi-analytical model has been developed, considering the pool composition as temporally variable. Based on Raoult's law, the molar fraction, the effective solubility and finally the mass discharge due to advection, dispersion and diffusion of each component are determined. The results significantly differ from studies on single-phase pools. It is shown that mass discharges can both increase and decrease over time and that the longevity of DNAPL pools as well as the time until threshold values are fullfilled will be significantly underestimated if Raoult's law is neglected. Additionally, a sensitivity analysis reveals that poorly soluble minor components must not be neglected, whereas highly soluble ones can.}, language = {de} } @book{FuhrmannGoertzKlagesetal.2020, author = {Fuhrmann, Michaela and Goertz, Stefanie and Klages, Benjamin and Last, Dominique and Strickroth, Sven and Schubarth, Wilfried and Mauermeister, Sylvi and Schulze-Reichelt, Friederike and Erdmann, Melinda and Dreyer, Martin and Konarski, Michael and T{\"a}gener, Judith and Lucke, Ulrike and Hafer, J{\"o}rg and Hartmann, Niklas and Nguyen, Thi To-Uyen and Wittkowski, Ariane and Prickett, David James and Degen, Andreas and Rost, Sophia and Kiy, Alexander and Wagner, Nelli and G{\"o}del, Corinna and Klinnert, Anne and Babbe, Caroline and Schneider, Marie and Hille, Kerstin}, title = {Lehre und Lernen entwickeln - Eine Frage der Gestaltung von {\"U}berg{\"a}ngen}, series = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, journal = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, number = {6}, editor = {Goertz, Stefanie and Klages, Benjamin and Last, Dominique and Strickroth, Sven}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-498-2}, issn = {2192-1075}, doi = {10.25932/publishup-47681}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-476815}, publisher = {Universit{\"a}t Potsdam}, pages = {336}, year = {2020}, abstract = {An der Universit{\"a}t Potsdam wurden im Rahmen des Qualit{\"a}tspakt Lehre-Projekts „Qualit{\"a}t etablieren in Lehre und Lernen (QueLL)" Maßnahmen f{\"u}r eine Verbesserung der Studienbedingungen und eine Weiterentwicklung der Lehre und des Lernens durchgef{\"u}hrt. Die w{\"a}hrend der neunj{\"a}hrigen Projektlaufzeit thematisierten Fragestellungen, erarbeiteten L{\"o}sungsans{\"a}tze und entsprechenden Erfahrungen werden im vorliegenden Sammelband in Form von wissenschaftlichen Auseinandersetzungen und Werkstattberichten dargestellt und diskutiert. Die Beitr{\"a}ge spiegeln in ihrer thematischen Vielfalt unterschiedliche universit{\"a}re {\"U}bergangsphasen wider, wie in diesem Fall den {\"U}bergang in die Hochschule, {\"U}berg{\"a}nge innerhalb der Hochschule (im Kontext der Organisationsentwicklung, der Weiterbildung akademischer Statusgruppen oder der Entwicklung einer digitalen Lehr-Lernkultur) und schließlich den {\"U}bergang in die Berufspraxis. Denn w{\"a}hrend der Projektlaufzeit hat sich gezeigt, dass die Gestaltung von Lehre und Lernen letztlich immer eine Gestaltung solcher {\"U}berg{\"a}nge ist: sowohl zwischen den innerinstitutionellen Ebenen und Bereichen als auch zwischen Akteur/innen der Hochschule und schließlich ebenso innerhalb des Student Life Cycle. Weiterhin wird anhand der Beitr{\"a}ge deutlich, dass die Entwicklung von Lehre und Studium nicht als isolierte Aufgabe verstanden werden kann, sondern in die Strukturen und Prozesse der Universit{\"a}t hineinwirken und Formen der Zusammenarbeit etablieren sollte, die es braucht, um Projekte nachhaltig zu gestalten. Ziel dieses Bandes ist es, zur Diskussion {\"u}ber Gelingensbedingungen einer nachhaltigen Entwicklung von Lehre und Lernen beizutragen. Damit richtet er sich an Akteur/innen aus der Hochschulleitung, an Lehrende und Forschende sowie Mitarbeitende des Third Space.}, language = {de} }