@article{WiethausMuellerNeumannetal.2009, author = {Wiethaus, Jessica and Mueller, Alexandra and Neumann, Meina and Neumann, Sandra and Leimk{\"u}hler, Silke and Narberhaus, Franz and Masepohl, Bernd}, title = {Specific interactions between four Molybdenum-binding proteins contribute to Mo-dependent gene regulation in Rhodobacter capsulatus}, issn = {0021-9193}, doi = {10.1128/Jb.00526-09}, year = {2009}, abstract = {The phototrophic purple bacterium Rhodobacter capsulatus encodes two transcriptional regulators, MopA and MopB, with partially overlapping and specific functions in molybdate-dependent gene regulation. Both MopA and MopB consist of an N-terminal DNA-binding helix-turn-helix domain and a C-terminal molybdate-binding di-MOP domain. They formed homodimers as apo-proteins and in the molybdate-bound state as shown by yeast two-hybrid (Y2H) studies, glutaraldehyde cross-linking, gel filtration chromatography, and copurification experiments. Y2H studies suggested that both the DNA- binding and the molybdate-binding domains contribute to dimer formation. Analysis of molybdate binding to MopA and MopB revealed a binding stoichiometry of four molybdate oxyanions per homodimer. Specific interaction partners of MopA and MopB were the molybdate transporter ATPase ModC and the molbindin-like Mop protein, respectively. Like other molbindins, the R. capsulatus Mop protein formed hexamers, which were stabilized by binding of six molybdate oxyanions per hexamer. Heteromer formation of MopA and MopB was shown by Y2H studies and copurification experiments. Reporter gene activity of a strictly MopA-dependent mop-lacZ fusion in mutant strains defective for either mopA, mopB, or both suggested that MopB negatively modulates expression of the mop promoter. We propose that depletion of the active MopA homodimer pool by formation of MopA-MopB heteromers might represent a fine-tuning mechanism controlling mop gene expression.}, language = {en} } @misc{CostardStadieRitteretal.2011, author = {Costard, Sylvia and Stadie, Nicole and Ritter, Christiane and Moll, Kristina and Landerl, Karin and Kohnen, Saskia and Kentner, Gerrit and Bethmann, Anja and Scheich, Henning and Brechmann, Andr{\´e} and De Kok, D{\"o}rte and Berger, Frauke and Sticher, Heike and Czepluch, Christine and M{\"a}tzener, Flurina and Wilmes, Stefanie and Hadert, Sandra and Frank, Ulrike and M{\"a}der, Mark and Westermann, Antje and Meinusch, Miriam and Neumann, Sandra and D{\"u}sterh{\"o}ft, Stefanie and Posse, Dorothea and Puritz, Caroline and Seidl, Rainer Ottis and Etzien, Maria and Machleb, Franziska and Lorenz, Antje and H{\"o}ger, Maria and Schr{\"o}der, Astrid and Busch, Tobias and Heide, Judith and Tagoe, Tanja and Watermeyer, Melanie and H{\"o}hle, Barbara and Kauschke, Christina}, title = {Spektrum Patholinguistik = Schwerpunktthema: Lesen lernen: Diagnostik und Therapie bei St{\"o}rungen des Leseerwerbs}, number = {4}, editor = {Hanne, Sandra and Fritzsche, Tom and Ott, Susan and Adelt, Anne}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-86956-145-5}, issn = {1869-3822}, doi = {10.25932/publishup-5155}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-53146}, year = {2011}, abstract = {Am 20. November 2010 fand an der Universit{\"a}t Potsdam das 4. Herbsttreffen Patholinguistik statt. Die Konferenzreihe wird regelm{\"a}ßig seit 2007 vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband ver{\"o}ffentlicht die Hauptvortr{\"a}ge des Herbsttreffens zum Thema "Lesen lernen: Diagnostik und Therapie bei St{\"o}rungen des Leseerwerbs". Des Weiteren sind die Beitr{\"a}ge promovierender bzw. promovierter PatholinguistInnen sowie der Posterpr{\"a}sentationen enthalten.}, language = {de} } @article{MeinuschNeumann2011, author = {Meinusch, Miriam and Neumann, Sandra}, title = {Systematisches Review zur Ermittlung wissenschaftlicher Evidenzen der Dysphagie bei LKGS-Fehlbildungen}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54291}, pages = {149 -- 170}, year = {2011}, language = {de} } @misc{NeumannQuintingRosenkranzetal.2019, author = {Neumann, Sandra and Quinting, Jana and Rosenkranz, Anna and De Beer, Carola and Jonas, Kristina and Stenneken, Prisca}, title = {Quality of life in adults with neurogenic speech-language-communication difficulties}, series = {Journal of communication disorders}, volume = {79}, journal = {Journal of communication disorders}, publisher = {Elsevier}, address = {New York}, issn = {0021-9924}, doi = {10.1016/j.jcomdis.2019.01.003}, pages = {24 -- 45}, year = {2019}, language = {en} } @article{ChipmanFerrierBrenaetal.2014, author = {Chipman, Ariel D. and Ferrier, David E. K. and Brena, Carlo and Qu, Jiaxin and Hughes, Daniel S. T. and Schroeder, Reinhard and Torres-Oliva, Montserrat and Znassi, Nadia and Jiang, Huaiyang and Almeida, Francisca C. and Alonso, Claudio R. and Apostolou, Zivkos and Aqrawi, Peshtewani and Arthur, Wallace and Barna, Jennifer C. J. and Blankenburg, Kerstin P. and Brites, Daniela and Capella-Gutierrez, Salvador and Coyle, Marcus and Dearden, Peter K. and Du Pasquier, Louis and Duncan, Elizabeth J. and Ebert, Dieter and Eibner, Cornelius and Erikson, Galina and Evans, Peter D. and Extavour, Cassandra G. and Francisco, Liezl and Gabaldon, Toni and Gillis, William J. and Goodwin-Horn, Elizabeth A. and Green, Jack E. and Griffiths-Jones, Sam and Grimmelikhuijzen, Cornelis J. P. and Gubbala, Sai and Guigo, Roderic and Han, Yi and Hauser, Frank and Havlak, Paul and Hayden, Luke and Helbing, Sophie and Holder, Michael and Hui, Jerome H. L. and Hunn, Julia P. and Hunnekuhl, Vera S. and Jackson, LaRonda and Javaid, Mehwish and Jhangiani, Shalini N. and Jiggins, Francis M. and Jones, Tamsin E. and Kaiser, Tobias S. and Kalra, Divya and Kenny, Nathan J. and Korchina, Viktoriya and Kovar, Christie L. and Kraus, F. Bernhard and Lapraz, Francois and Lee, Sandra L. and Lv, Jie and Mandapat, Christigale and Manning, Gerard and Mariotti, Marco and Mata, Robert and Mathew, Tittu and Neumann, Tobias and Newsham, Irene and Ngo, Dinh N. and Ninova, Maria and Okwuonu, Geoffrey and Ongeri, Fiona and Palmer, William J. and Patil, Shobha and Patraquim, Pedro and Pham, Christopher and Pu, Ling-Ling and Putman, Nicholas H. and Rabouille, Catherine and Ramos, Olivia Mendivil and Rhodes, Adelaide C. and Robertson, Helen E. and Robertson, Hugh M. and Ronshaugen, Matthew and Rozas, Julio and Saada, Nehad and Sanchez-Gracia, Alejandro and Scherer, Steven E. and Schurko, Andrew M. and Siggens, Kenneth W. and Simmons, DeNard and Stief, Anna and Stolle, Eckart and Telford, Maximilian J. and Tessmar-Raible, Kristin and Thornton, Rebecca and van der Zee, Maurijn and von Haeseler, Arndt and Williams, James M. and Willis, Judith H. and Wu, Yuanqing and Zou, Xiaoyan and Lawson, Daniel and Muzny, Donna M. and Worley, Kim C. and Gibbs, Richard A. and Akam, Michael and Richards, Stephen}, title = {The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima}, series = {PLoS biology}, volume = {12}, journal = {PLoS biology}, number = {11}, publisher = {PLoS}, address = {San Fransisco}, issn = {1545-7885}, doi = {10.1371/journal.pbio.1002005}, pages = {24}, year = {2014}, abstract = {Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.}, language = {en} } @misc{TanDueringWildeetal.2023, author = {Tan, Sarah and D{\"u}ring, Sarah and Wilde, Alina and Hamburger, Lara and Fritzsche, Tom and Felsing, Ulrike and Lauer, Norina and Corsten, Sabine and Ostermann, Frank and Nonn, Kerstin and Nerz, Verena and Neumann, Sandra and Zauke, Svenja and Sandrieser, Patricia and Steinberg, Romy Simone and Thurmann, Anika and D{\"o}rr, Fiona and Bilda, Kerstin and Kluth, Alicia and Lemire-Tremblay, Marilyne and Jamey, Kevin and Dalla Bella, Simone and Falk, Simone and Kleing{\"u}nther, Constanze and Gabler, Katrin and Elligsen, Chiara and Weiland, Katharina and Wiehe, Lea and Wahl, Michael and Binczyk, Sarah and Staebel, Cornelia and Jung, Stefanie and Eikerling, Maren and Czok, Clara and Sallat, Stephan and Collasius, Valerie and Grahovac, Tena}, title = {Spektrum Patholinguistik Band 16. Schwerpunktthema: Schnittstelle Alltag: Transfer und Teilhabe in der Sprachtherapie}, number = {16}, editor = {Tan, Sarah and D{\"u}ring, Sarah and Wilde, Alina and Hamburger, Lara and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-559-0}, issn = {1866-9433}, doi = {10.25932/publishup-59043}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-590433}, pages = {viii, 234}, year = {2023}, abstract = {Das 16. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Schnittstelle Alltag: Transfer und Teilhabe in der Sprachtherapie« fand am 19.11.2022 als Online-Veranstaltung statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl), seit 2021 vom Deutschen Bundesverband f{\"u}r akademische Sprachtherapie und Logop{\"a}die (dbs) in Kooperation mit der Universit{\"a}t Potsdam durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die Vortr{\"a}ge zum Schwerpunktthema sowie die Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @article{NeumannZauke2023, author = {Neumann, Sandra and Zauke, Svenja}, title = {Der FOCUS©-34-G als Fragebogen zur Einsch{\"a}tzung der kommunikativen Partizipation bei Kindern mit sprachlich-kommunikativem Unterst{\"u}tzungsbedarf unter sechs Jahren}, series = {Spektrum Patholinguistik 16}, journal = {Spektrum Patholinguistik 16}, number = {16}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-559-0}, issn = {1866-9433}, doi = {10.25932/publishup-61344}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-613441}, pages = {83 -- 94}, year = {2023}, abstract = {Der vorliegende Beitrag stellt die deutsche kurze Version des kommunikativen Partizipationsassessments ‚Fokus auf den Erfolg der Kommunikation f{\"u}r Kinder unter 6 Jahren (FOCUS©-34-G)' (Thomas-Stonell et al., 2012a) vor. Es werden die Entwicklung und psychometrische Validierung, Zielsetzung, Durchf{\"u}hrung und Auswertung f{\"u}r den konkreten Einsatz in der sprachtherapeutischen Praxis beschrieben.}, language = {de} } @article{ZaukeNeumann2023, author = {Zauke, Svenja and Neumann, Sandra}, title = {Die kommunikative Partizipation von Kindern mit Sprachentwicklungsst{\"o}rungen im Vorschulalter: erste Daten mit dem FOCUS©-34-G}, series = {Spektrum Patholinguistik 16}, journal = {Spektrum Patholinguistik 16}, number = {16}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-559-0}, issn = {1866-9433}, doi = {10.25932/publishup-61348}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-613489}, pages = {117 -- 133}, year = {2023}, abstract = {Bei Kindern mit Sprachentwicklungsst{\"o}rungen (SES) k{\"o}nnen sich Symptome auf sprachlich-funktionaler Ebene sehr variabel auf die kommunikative Partizipation im Alltag auswirken. Kommunikative Partizipation wird definiert als sprachlich-kommunikatives Teilnehmen an Lebenssituationen, in denen Wissen, Informationen, Ideen oder Gef{\"u}hle ausgetauscht werden. Der deutschsprachige ‚Fokus auf den Erfolg der Kommunikation f{\"u}r Kinder unter sechs Jahren' (FOCUS©-34-G) ist ein evaluierter Fragebogen zur Fremdeinsch{\"a}tzung der kommunikativen Partizipation von Kindern (1;6 bis 5;11 Jahre). Ziel unserer Studie war die Untersuchung der Auswirkungen einer SES auf die kommunikative Partizipation betroffener Kinder im Alter zwischen 2;0 und 4;11 Jahren anhand des FOCUS©-34-G. Eltern von Kindern mit SES f{\"u}llten den FOCUS©-34-G sowie einen Demografie-Bogen aus. Es konnten erste Daten von 22 Kindern (16 Jungen) im Alter zwischen 2;7 und 3;11 (M = 3;3 Jahre, SD = 0;4 Jahre) erhoben werden. Im FOCUS©-34-G erreichten Kinder mit SES einen Gesamtwert zwischen 54 und 197 (M = 120.55, SD = 40.91) von 238 maximal m{\"o}glichen Punkten. Diese Ergebnisse zeigen eine eingeschr{\"a}nkte kommunikative Partizipation von Kindern mit SES, die es in einer ICF-CY-orientierten sprachtherapeutischen Intervention zu beachten gilt. Als klinisches Assessmentinstrument kann der FOCUS©-34-G als Kurzversion des FOCUS©-G als geeignet angesehen werden.}, language = {de} }