@article{NitezkiSchulzKraemer2018, author = {Nitezki, Tina and Schulz, Nadja and Kr{\"a}mer, Stephanie}, title = {Color matters}, series = {Laboratory animals : the international journal of laboratory animal science and welfare}, volume = {52}, journal = {Laboratory animals : the international journal of laboratory animal science and welfare}, number = {6}, publisher = {Sage Publ.}, address = {Thousand Oaks}, issn = {0023-6772}, doi = {10.1177/0023677218766370}, pages = {611 -- 620}, year = {2018}, abstract = {Concerning standardization of laboratory animal husbandry, only exiguous changes of habitat can potentially influence animal physiology or results of behavioral tests. Routinely, mice chow is dyed when different types of diets are dispensed. Given the fact that the dye itself has no effects on food odor or flavor, we wanted to test the hypothesis that the color of chow has an impact on food uptake in mice. Twelve-week-old male mice of different strains (C57BL/6J, DBA/2J, C3H/HeJ, BALB/cJ; n = 12/strain) were single-housed in PhenoMaster (R) cages. After acclimatization standard mice chow in different colors was administered. Food intake was monitored as a two-alternative choice test of different color combinations. All animals had an average food intake of 3 g/d and no preferences were observed when a combination of identically colored food was offered. Preference tests yielded significant aversion to blue food and significant attraction to yellow and green food in C57BL/6 and DBA/2J mice. In C3H/HeJ and BALB/cJ mice no color-related pattern occurred. Selected mice strains have known differences concerning functionality of their visual sense. C57BL/6 and DBA/2 mice are considered to be normal sighted at testing age, BALB/c is representative for albino strains and C3H mice carry mutations resulting in retinal alterations. Results suggesting that normal-sighted mice would be selective concerning food color when given the choice. Nevertheless, this does not influence overall quantity of food intake when animals were provided solely with food colored with a single dye. Moreover, visually impaired mice showed no color-related food preferences.}, language = {en} } @book{BeckmannBergmannTitosetal.2019, author = {Beckmann, Susanne and Bergmann, Valentin Friedrich and Titos, Marcos Bolivar and Brzezina, Claudia and Elke, Katrin and Falky, Paulina and Jahnke, Nadja and Janke, Stefan and Kubitz, Robert and Lesinski, Theresa and Pelz, Klara and Schmid, Vincent Leonhard and Schulz, Laura and Spiller, Friedrich and Weskamp, Madeleine and Wille, Johanna and Zenk, Johannes}, title = {Wege entstehen beim Gehen}, editor = {Bossen, Anja}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-443-2}, doi = {10.25932/publishup-43428}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-434284}, publisher = {Universit{\"a}t Potsdam}, pages = {60}, year = {2019}, abstract = {Musicalarbeit in der Schule, vom Mini-Musical bis hin zu groß angelegten Schulmusicals, erfreut sich sowohl bei Sch{\"u}lerinnen und Sch{\"u}lern als auch bei Musiklehrkr{\"a}ften großer Beliebtheit und eines oftmals außerordentlichen, teils auch untersch{\"a}tzten Engagements. Dessen ungeachtet gibt es nur wenig musikdidaktische Fachliteratur zu diesem Thema und es liegen bislang nur wenige Forschungsarbeiten vor, die wegweisend f{\"u}r die Umsetzung von Musicalprojekten an Schulen sind. Auch in der Musiklehrerbildung spielt Musicalarbeit nur eine marginale Rolle. Die vorliegende Publikation m{\"o}chte dazu beitragen, diese L{\"u}cke zu verringern. Sie ist das Ergebnis des Masterseminars „Musicalarbeit in der Schule" am Lehrstuhl f{\"u}r Musikp{\"a}dagogik und Musikdidaktik der Universit{\"a}t Potsdam, das begleitend zur k{\"u}nstlerischen Erarbeitung des Musicals „Elion" durch Studierende der Universit{\"a}t Potsdam im Sommersemester 2018 stattfand. Im Zentrum des Seminars standen p{\"a}dagogische sowie methodisch-didaktische Fragestellungen in den Bereichen Gesang, Choreografie und Theaterarbeit. Des Weiteren wurden M{\"o}glichkeiten und p{\"a}dagogische Potenziale fach{\"u}bergreifenden und f{\"a}cherverbindenden Arbeitens er{\"o}rtert. Zu diesem Seminar wurden Musicalexperten aus verschiedenen schulischen Kontexten eingeladen, die den Studierenden Einblicke in ihre langj{\"a}hrigen Praxiserfahrungen gew{\"a}hrten und ihre Erfahrungen zur Diskussion stellten. Die vorliegende Publikation wurde abschließend von den Seminarteilnehmern selbst erarbeitet und stellt eine Zusammenfassung des Seminars dar. Sie versteht sich als Entscheidungshilfe f{\"u}r oder gegen Musicalarbeit in der Schule und als Leitfaden f{\"u}r den Einstieg in die Praxis.}, language = {de} } @phdthesis{Schulz2011, author = {Schulz, Nadja}, title = {Die Rolle der 3-L-Hydroxyacyl-Coenzym-A-Dehydrogenase in der Regulation des {\"o}rpergewichts, der Thermogenese sowie der Glucosehom{\"o}ostase}, address = {Potsdam}, pages = {92 S.}, year = {2011}, language = {de} } @article{GalhuberMichenthalerHeiningeretal.2022, author = {Galhuber, Markus and Michenthaler, Helene and Heininger, Christoph and Reinisch, Isabel and N{\"o}ssing, Christoph and Krstic, Jelena and Kupper, Nadja and Moyschewitz, Elisabeth and Auer, Martina and Heitzer, Ellen and Ulz, Peter and Birner-Gruenberger, Ruth and Liesinger, Laura and Lenihan-Geels, Georgia Ngawai and Oster, Moritz and Spreitzer, Emil and Chiozzi, Riccardo Zenezini and Schulz, Tim J. and Schupp, Michael and Madl, Tobias and Heck, Albert J. R. and Prokesch, Andreas}, title = {Complementary omics strategies to dissect p53 signaling networks under nutrient stress}, series = {Cellular and molecular life sciences}, volume = {79}, journal = {Cellular and molecular life sciences}, number = {6}, publisher = {Springer Nature}, address = {Basel}, issn = {1420-682X}, doi = {10.1007/s00018-022-04345-8}, pages = {22}, year = {2022}, abstract = {Signaling trough p53is a major cellular stress response mechanism and increases upon nutrient stresses such as starvation. Here, we show in a human hepatoma cell line that starvation leads to robust nuclear p53 stabilization. Using BioID, we determine the cytoplasmic p53 interaction network within the immediate-early starvation response and show that p53 is dissociated from several metabolic enzymes and the kinase PAK2 for which direct binding with the p53 DNA-binding domain was confirmed with NMR studies. Furthermore, proteomics after p53 immunoprecipitation (RIME) uncovered the nuclear interactome under prolonged starvation, where we confirmed the novel p53 interactors SORBS1 (insulin receptor signaling) and UGP2 (glycogen synthesis). Finally, transcriptomics after p53 re-expression revealed a distinct starvation-specific transcriptome response and suggested previously unknown nutrient-dependent p53 target genes. Together, our complementary approaches delineate several nodes of the p53 signaling cascade upon starvation, shedding new light on the mechanisms of p53 as nutrient stress sensor. Given the central role of p53 in cancer biology and the beneficial effects of fasting in cancer treatment, the identified interaction partners and networks could pinpoint novel pharmacologic targets to fine-tune p53 activity.}, language = {en} }