@article{OmoleMoshiHeydenreichetal.2019,
  author    = {Omole, Ruth Anyango and Moshi, Mainen Julius and Heydenreich, Matthias and Malebo, Hamisi Masanja and Gathirwa, Jeremiah Waweru and Ochieng, Sharon Alice and Omosa, Leonida Kerubo and Midiwo, Jacob Ogweno},
  title     = {Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (L.F.) Sol. Ex roem. \& schult},
  series = {Phytochemistry letters},
  volume    = {30},
  journal   = {Phytochemistry letters},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1874-3900},
  doi       = {10.1016/j.phytol.2019.02.019},
  pages     = {194 -- 200},
  year      = {2019},
  abstract  = {Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2: MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscopic techniques: UV-vis, IR, CD, 1D, 2D and MS. Two fractions (RAO-43B and RAO-43D) and the isolated compounds were tested for activity against CQ susceptible (D6) and resistant (W2) Plasmodium falciparum parasite strains, in vitro and the IC50 values determined. While the whole extract and some resultant fractions displayed moderate activity, the isolated compounds exhibited mild anti-plasmodial activity against the both strains ranging from IC50 value of 328 mu M in 1 to 93 mu M in 3 against W2 strain.},
  language  = {en}
}
@article{KeruboMidiwoDereseetal.2013,
  author    = {Kerubo, Leonidah Omosa and Midiwo, Jacob Ogweno and Derese, Solomon and Langat, Moses K. and Akala, Hoseah M. and Waters, Norman C. and Peter, Martin and Heydenreich, Matthias},
  title     = {Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus},
  series = {Natural product communications : an international journal for communications and reviews},
  volume    = {8},
  journal   = {Natural product communications : an international journal for communications and reviews},
  number    = {2},
  publisher = {NPC},
  address   = {Westerville},
  issn      = {1934-578X},
  pages     = {175 -- 176},
  year      = {2013},
  abstract  = {From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.},
  language  = {en}
}