@article{SeilerSremcevicSeissetal.2017, author = {Seiler, Martin and Sremcevic, Miodrag and Seiss, Martin and Hoffmann, Holger and Spahn, Frank}, title = {A Librational Model for the Propeller Bleriot in the Saturnian Ring System}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, volume = {840}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2041-8205}, doi = {10.3847/2041-8213/aa6d73}, pages = {6}, year = {2017}, language = {en} } @unpublished{AcharyaActisAghajanietal.2013, author = {Acharya, B. S. and Actis, M. and Aghajani, T. and Agnetta, G. and Aguilar, J. and Aharonian, Felix A. and Ajello, M. and Akhperjanian, A. G. and Alcubierre, M. and Aleksic, J. and Alfaro, R. and Aliu, E. and Allafort, A. 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Becker and Beckmann, Volker and Bednarek, W. and Behera, B. and Belluso, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernard, F. and Bernardino, T. and Bernl{\"o}hr, K. and Bhat, N. and Bhattacharyya, S. and Bigongiari, C. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Biteau, Jonathan and Bitossi, M. and Blake, S. and Blanch Bigas, O. and Blasi, P. and Bobkov, A. A. and Boccone, V. and Boettcher, Markus and Bogacz, L. and Bogart, J. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Bonifacio, P. and Bonnoli, G. and Bordas, Pol and Borgland, A. W. and Borkowski, Janett and Bose, R. and Botner, O. and Bottani, A. and Bouchet, L. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Bringmann, T. and Brook, P. and Brun, Pierre and Brunetti, L. and Buanes, T. and Buckley, J. H. and Buehler, R. and Bugaev, V. and Bulgarelli, A. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Camprecios, J. and Canestrari, R. and Cantu, S. and Capalbi, M. and Caraveo, P. A. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casanova, Sabrina and Casiraghi, M. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, M. and Chabanne, E. and Chadwick, Paula M. and Champion, C. and Chen, Andrew and Chiang, J. and Chiappetti, L. and Chikawa, M. and Chitnis, V. R. and Chollet, F. and Chudoba, J. and Cieslar, M. and Cillis, A. N. and Cohen-Tanugi, J. and Colafrancesco, Sergio and Colin, P. and Calome, J. and Colonges, S. and Compin, M. and Conconi, P. and Conforti, V. and Connaughton, V. and Conrad, Jan and Contreras, J. 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T. and de Naurois, M. and de Oliveira, Y. and de Ona Wilhelmi, E. and de Souza, V. and Decerprit, G. and Decock, G. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Della Volpe, D. and Demange, P. and Depaola, G. and Dettlaff, A. and Di Paola, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickherber, R. and Dickinson, H. and Diez-Blanco, V. and Digel, S. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Dohmke, M. and Domainko, W. and Prester, Dijana Dominis and Donat, A. and Dorner, D. and Doro, M. and Dournaux, J-L. and Drake, G. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Dumas, D. and Dumm, J. and Durand, D. and Dyks, J. and Dyrda, M. and Ebr, J. and Edy, E. and Egberts, Kathrin and Eger, P. and Einecke, S. and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Engelhaupt, D. and Enomoto, R. and Ernenwein, J-P and Errando, M. and Etchegoyen, A. and Evans, P. and Falcone, A. and Fantinel, D. and Farakos, K. and Farnier, C. and Fasola, G. and Favill, B. and Fede, E. and Federici, S. and Fegan, S. and Feinstein, F. and Ferenc, D. and Ferrando, P. and Fesquet, M. and Fiasson, A. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. 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K. and Yamamoto, H. and Yamamoto, T. and Yamazaki, R. and Yanagita, S. and Yebras, J. M. and Yelos, D. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zacharias, M. and Zajczyk, A. and Zanin, R. and Zdziarski, A. and Zech, Alraune and Zhao, A. and Zhou, X. and Zietara, K. and Ziolkowski, J. and Ziolkowski, P. and Zitelli, V. and Zurbach, C. and Zychowski, P.}, title = {Introducing the CTA concept}, series = {Astroparticle physics}, volume = {43}, journal = {Astroparticle physics}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, organization = {CTA Consortium}, issn = {0927-6505}, doi = {10.1016/j.astropartphys.2013.01.007}, pages = {3 -- 18}, year = {2013}, abstract = {The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.}, language = {en} } @article{SeissAlbersSremčevićetal.2019, author = {Seiß, Martin and Albers, Nicole and Sremčević, Miodrag and Schmidt, J{\"u}rgen and Salo, Heikki and Seiler, Michael and Hoffmann, Holger and Spahn, Frank}, title = {Hydrodynamic Simulations of Moonlet-induced Propellers in Saturn's Rings}, series = {The astronomical journal}, volume = {157}, journal = {The astronomical journal}, number = {1}, publisher = {IOP Publishing Ltd.}, address = {Bristol}, issn = {0004-6256}, doi = {10.3847/1538-3881/aaed44}, pages = {11}, year = {2019}, abstract = {One of the biggest successes of the Cassini mission is the detection of small moons (moonlets) embedded in Saturns rings that cause S-shaped density structures in their close vicinity, called propellers. Here, we present isothermal hydrodynamic simulations of moonlet-induced propellers in Saturn's A ring that denote a further development of the original model. We find excellent agreement between these new hydrodynamic and corresponding N-body simulations. Furthermore, the hydrodynamic simulations confirm the predicted scaling laws and the analytical solution for the density in the propeller gaps. Finally, this mean field approach allows us to simulate the pattern of the giant propeller Bl{\´e}riot, which is too large to be modeled by direct N-body simulations. Our results are compared to two stellar occultation observations by the Cassini Ultraviolet Imaging Spectrometer (UVIS), which intersect the propeller Bl{\´e}riot. Best fits to the UVIS optical depth profiles are achieved for a Hill radius of 590 m, which implies a moonlet diameter of about 860 m. Furthermore, the model favors a kinematic shear viscosity of the surrounding ring material of ν0 = 340 cm2 s-1, a dispersion velocity in the range of 0.3 cm s-1 < c0 < 1.5 cm s-1, and a fairly high bulk viscosity 7 < ξ0/ν0 < 17. These large transport values might be overestimated by our isothermal ring model and should be reviewed by an extended model including thermal fluctuations.}, language = {en} } @article{SeilerSeissHoffmannetal.2019, author = {Seiler, Michael and Seiß, Martin and Hoffmann, Holger and Spahn, Frank}, title = {Hydrodynamic Simulations of Asymmetric Propeller Structures in Saturn's Rings}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, volume = {243}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0067-0049}, doi = {10.3847/1538-4365/ab26b0}, pages = {16}, year = {2019}, abstract = {The observation of the non-Keplerian behavior of propeller structures in Saturn's outer A ring raises the question: how does the propeller respond to the wandering of the central embedded moonlet? Here, we study numerically how the structural imprint of the propeller changes for a libration of the moonlet. It turns out that the libration induces an asymmetry in the propeller, which depends on the libration period and amplitude of the moonlet. Further, we study the dependence of the asymmetry on the libration period and amplitude for a moonlet with a 400 m Hill radius, which is located in the outer A ring. This allows us to apply our findings to the largest known propeller Bl{\´e}riot, which is expected to be of a similar size. For Bl{\´e}riot, we can conclude that, supposing the moonlet is librating with the largest observed period of 11.1 yr and an azimuthal amplitude of about 1845 km, a small asymmetry should be measurable but depends on the moonlet's libration phase at the observation time. The longitude residuals of other trans-Encke propellers (e.g., Earhart) show amplitudes similar to Bl{\´e}riot, which might allow us to observe larger asymmetries due to their smaller azimuthal extent, allowing us to scan the whole gap structure for asymmetries in one observation. Although the librational model of the moonlet is a simplification, our results are a first step toward the development of a consistent model for the description of the formation of asymmetric propellers caused by a freely moving moonlet.}, language = {en} } @article{HsuSchmidtKempfetal.2018, author = {Hsu, Hsiang-Wen and Schmidt, J{\"u}rgen and Kempf, Sascha and Postberg, Frank and Moragas-Klostermeyer, Georg and Seiss, Martin and Hoffmann, Holger and Burton, Marcia and Ye, ShengYi and Kurth, William S. and Horanyi, Mihaly and Khawaja, Nozair and Spahn, Frank and Schirdewahn, Daniel and Moore, Luke and Cuzzi, Jeff and Jones, Geraint H. and Srama, Ralf}, title = {In situ collection of dust grains falling from Saturn's rings into its atmosphere}, series = {Science}, volume = {362}, journal = {Science}, number = {6410}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.aat3185}, pages = {49 -- +}, year = {2018}, abstract = {Saturn's main rings are composed of >95\% water ice, and the nature of the remaining few percent has remained unclear. The Cassini spacecraft's traversals between Saturn and its innermost D ring allowed its cosmic dust analyzer (CDA) to collect material released from the main rings and to characterize the ring material infall into Saturn. We report the direct in situ detection of material from Saturn's dense rings by the CDA impact mass spectrometer. Most detected grains are a few tens of nanometers in size and dynamically associated with the previously inferred "ring rain." Silicate and water-ice grains were identified, in proportions that vary with latitude. Silicate grains constitute up to 30\% of infalling grains, a higher percentage than the bulk silicate content of the rings.}, language = {en} } @article{BeerenwinkelSingLengaueretal.2005, author = {Beerenwinkel, Niko and Sing, Tobias and Lengauer, Thomas and Rahnenfuhrer, Joerg and Roomp, Kirsten and Savenkov, Igor and Fischer, Roman and Hoffmann, Daniel and Selbig, Joachim and Korn, Klaus and Walter, Hauke and Berg, Thomas and Braun, Patrick and Faetkenheuer, Gerd and Oette, Mark and Rockstroh, Juergen and Kupfer, Bernd and Kaiser, Rolf and Daeumer, Martin}, title = {Computational methods for the design of effective therapies against drug resistant HIV strains}, year = {2005}, abstract = {The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data}, language = {en} } @article{BurattiThomasRoussosetal.2019, author = {Buratti, Bonnie J. and Thomas, P. C. and Roussos, E. and Howett, Carly and Seiss, Martin and Hendrix, A. R. and Helfenstein, Paul and Brown, R. H. and Clark, R. N. and Denk, Tilmann and Filacchione, Gianrico and Hoffmann, Holger and Jones, Geraint H. and Khawaja, N. and Kollmann, Peter and Krupp, Norbert and Lunine, Jonathan and Momary, T. W. and Paranicas, Christopher and Postberg, Frank and Sachse, Manuel and Spahn, Frank and Spencer, John and Srama, Ralf and Albin, T. and Baines, K. H. and Ciarniello, Mauro and Economou, Thanasis and Hsu, Hsiang-Wen and Kempf, Sascha and Krimigis, Stamatios M. and Mitchell, Donald and Moragas-Klostermeyer, Georg and Nicholson, Philip D. and Porco, C. C. and Rosenberg, Heike and Simolka, Jonas and Soderblom, Laurence A.}, title = {Close Cassini flybys of Saturn's ring moons Pan, Daphnis, Atlas, Pandora, and Epimetheus}, series = {Science}, volume = {364}, journal = {Science}, number = {6445}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.aat2349}, pages = {1053}, year = {2019}, abstract = {Saturn's main ring system is associated with a set of small moons that either are embedded within it or interact with the rings to alter their shape and composition. Five close flybys of the moons Pan, Daphnis, Atlas, Pandora, and Epimetheus were performed between December 2016 and April 2017 during the ring-grazing orbits of the Cassini mission. Data on the moons' morphology, structure, particle environment, and composition were returned, along with images in the ultraviolet and thermal infrared. We find that the optical properties of the moons' surfaces are determined by two competing processes: contamination by a red material formed in Saturn's main ring system and accretion of bright icy particles or water vapor from volcanic plumes originating on the moon Enceladus.}, language = {en} } @article{LeueHoffmannHieroldetal.2019, author = {Leue, Martin and Hoffmann, Carsten and Hierold, Wilfried and Sommer, Michael}, title = {In-situ multi-sensor characterization of soil cores along an erosion deposition gradient}, series = {Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution}, volume = {182}, journal = {Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0341-8162}, doi = {10.1016/j.catena.2019.104140}, pages = {11}, year = {2019}, abstract = {Soil landscape research is faced with wide-ranging questions of soil erosion, precision farming, and agricultural risk management. Digital Soil Morphometrics is a powerful tool to provide respective answers or recommendations but requires soil data from the pedon-to-field scale with high horizontal and vertical resolutions, including the subsoil. We present an efficient sampling and measurement method for easily obtainable soil driving cores with low-destructive preparation. Elemental contents and soil organic and mineral matter composition were measured rapidly and in large numbers using a multi-sensor approach, i.e., visible and near infrared (Vis-NIR), diffuse reflectance infrared Fourier transform (DRIFT), and X-ray fluorescence (XRF) spectroscopy. The suitability of the approach with respect to three-dimensional soil landscape models was tested using soils along a slope representing different stages of erosion and deposition in a hummocky landscape under arable land use (Calcaric Regosols, Calcic Luvisols, Luvic Stagnosols, Gleyic-Colluvic Regosols). The combination of soil core sampling, pedological description, and three spectroscopic techniques enabled rapid determination and interpretation of horizontal and vertical spatial distributions of soil organic carbon (SOC), soil organic and mineral matter composition, as well as CaCO3, Fe, and Mn contents. Depth profiles for SOC, CaCO3, and Fe contents were suitable indicators for site-specific degrees of erosion and matter transport processes at the pedon-to-field scale. Fe and Mn profiles helped identifying zones of reductive and oxic domains in subsoils (gleyzation). Further methodical developments should implement plant-availability of nutrients, characterization of Fe oxides, and calibration of the spectroscopic techniques to field-moist samples.}, language = {en} } @misc{LeitnerEtteKoelbeletal.2006, author = {Leitner, Ulrike and Ette, Ottmar and K{\"o}lbel, Bernd and Sauerwein, Martin and Sauerwein, Katrin and K{\"o}lbel, Steffen and Terken, Lucie and Rupke, Nicolaas A. and Weihrauch, Franz-J. and Werner, Petra and Hoffmann, Robert}, title = {HiN : Alexander von Humboldt im Netz}, volume = {VII}, number = {12}, editor = {Ette, Ottmar and Knobloch, Eberhard}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, doi = {10.18443/hinvol7iss122006}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-35481}, pages = {110}, year = {2006}, abstract = {- Ulrike Leitner: Aus dem Humboldt-Nachlaß: Juan Jos{\´e} de Oteyzas Beschreibung der Pyramiden von Teotihuac{\´a}n - Ottmar Ette: Alexander von Humboldt, die Humboldtsche Wissenschaft und ihre Relevanz im Netzzeitalter - Bernd K{\"o}lbel, Martin Sauerwein, Katrin Sauerwein, Steffen K{\"o}lbel und Lucie Terken: Alexander von Humboldt und seine geognostischen Studien in G{\"o}ttingen - Nicolaas A. Rupke: A Metabiography of Alexander von Humboldt - Franz-J. Weihrauch: Nachrichten aus Amerika oder wie man in Koblenz von Humboldts Reise nach Amerika erfuhr - Petra Werner Himmelsblau. Bemerkungen zum Thema „Farben" in Humboldts Alterswerk Kosmos. Entwurf einer physischen Weltbeschreibung - Robert Hoffmann: Die Entstehung einer Legende. Alexander von Humboldts angeblicher Ausspruch {\"u}ber Salzburg.}, language = {de} } @misc{BuehrerFastenrathHaussigetal.2011, author = {B{\"u}hrer, Torben and Fastenrath, Ulrich and Haußig, Hans-Michael and Hoffmann, Jan Martin and Kashgar, Maral and Ladwig, Bernd and Liese, Andrea Margit and L{\"o}hr, Tillmann and Sch{\"a}fer, Bernhard and Scharlau, Maria and Teichmann, Michael}, title = {MenschenRechtsMagazin : Informationen | Meinungen | Analysen}, volume = {16}, number = {2}, editor = {Gunnarsson, Logi and Klein, Eckart and Zimmermann, Andreas}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1434-2820}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-55522}, year = {2011}, abstract = {Aus dem Inhalt: - Neue Entwicklungen im regionalen Menschenrechtsschutz: eine politikwissenschaftliche Betrachtung des institutionellen Designs und der Dynamik des derzeitigen menschenrechtlichen Regionalismus - Das menschenrechtliche Diskriminierungsverbot und seine Grenzen - Die Individualbeschwerde zur Kinderrechtskonvention - BVerfG: Fraport - Urteil vom 22. Februar 2011}, language = {de} } @article{HoffmannSeissSpahn2013, author = {Hoffmann, H. and Seiß, Martin and Spahn, Frank}, title = {Vertical relaxation of a moonlet propeller in Saturn's a ring}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, volume = {765}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2041-8205}, doi = {10.1088/2041-8205/765/1/L4}, pages = {3}, year = {2013}, abstract = {Two images, taken by the Cassini spacecraft near Saturn's equinox in 2009 August, show the Earhart propeller casting a 350 km long shadow, offering the opportunity to watch how the ring height, excited by the propeller moonlet, relaxes to an equilibrium state. From the shape of the shadow cast and a model of the azimuthal propeller height relaxation, we determine the exponential cooling constant of this process to be lambda = 0.07 +/- 0.02 km(-1), and thereby determine the collision frequency of the ring particles in the vertically excited region of the propeller to be omega(c)/Omega = 0.9 +/- 0.2.}, language = {en} } @article{HoffmannSeissSaloetal.2015, author = {Hoffmann, Holger and Seiss, Martin and Salo, Heikki and Spahn, Frank}, title = {Vertical structures induced by embedded moonlets in Saturn's rings}, series = {Icarus : international journal of solar system studies}, volume = {252}, journal = {Icarus : international journal of solar system studies}, publisher = {Elsevier}, address = {San Diego}, issn = {0019-1035}, doi = {10.1016/j.icarus.2015.02.003}, pages = {400 -- 414}, year = {2015}, abstract = {We study the vertical extent of propeller structures in Saturn's rings (i) by extending the model of Spahn and Sremcevic (Spahn, F., Sremcevic, M. [2000]. Astron. Astrophys., 358, 368-372) to include the vertical direction and (ii) by performing N-body box simulations of a perturbing moonlet embedded into the rings. We find that the gravitational interaction of ring particles with a non-inclined moonlet does not induce considerable vertical excursions of ring particles, but causes a considerable thermal motion in the ring plane. We expect ring particle collisions to partly convert the lateral induced thermal motion into vertical excursions of ring particles in the course of a quasi-thermalization. The N-body box simulations lead to maximal propeller heights of about 0.6-0.8 Hill radii of the embedded perturbing moonlet. Moonlet sizes estimated by this relation are in good agreement with size estimates from radial propeller scalings for the propellers Bleriot and Earhart. For large propellers, the extended hydrodynamical propeller model predicts an exponential propeller height relaxation, confirmed by N-body box simulations of non-self gravitating ring particles. Exponential cooling constants, calculated from the hydrodynamical propeller model agree fairly well with values from fits to the tail of the azimuthal height decay of the N-body box simulations. From exponential cooling constants, determined from shadows cast by the propeller Earhart and imaged by the Cassini spacecraft, we estimate collision frequencies of about 6 collisions per particle per orbit in the propeller gap region and about 11 collisions per particle per orbit in the propeller wake region. (C) 2015 Elsevier Inc. All rights reserved.}, language = {en} } @article{KuhneDippongFlemigetal.2014, author = {Kuhne, Maren and Dippong, Martin and Flemig, Sabine and Hoffmann, Katrin and Petsch, Kristin and Schenk, J{\"o}rg A. and Kunte, Hans-J{\"o}rg and Schneider, Rudolf J.}, title = {Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA}, series = {Journal of immunological methods}, volume = {413}, journal = {Journal of immunological methods}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1759}, doi = {10.1016/j.jim.2014.07.004}, pages = {45 -- 56}, year = {2014}, abstract = {A novel method that optimizes the screening for antibody-secreting hapten-specific hybridoma cells by using flow cytometry is described. Cell clones specific for five different haptens were analyzed. We selectively double stained and analyzed fixed hybridoma cells with fluorophore-labeled haptens to demonstrate the target-selectivity, and with a fluorophore-labeled anti-mouse IgG antibody to characterize the level of surface expression of membrane-bound IgGs. ELISA measurements with the supernatants of the individual hybridoma clones revealed that antibodies from those cells, which showed the highest fluorescence intensities in the flow cytometric analysis, also displayed the highest affinities for the target antigens. The fluorescence intensity of antibody-producing cells corresponded well with the produced antibodies' affinities toward their respective antigens. Immunohistochemical staining verified the successful double labeling of the cells. Our method makes it possible to perform a high-throughput screening for hybridoma cells, which have both an adequate IgG production rate and a high target affinity. (C) 2014 Elsevier B.V. All rights reserved.}, language = {en} } @article{JayNorellEckertetal.2018, author = {Jay, Raphael M. and Norell, Jesper and Eckert, Sebastian and Hantschmann, Markus and Beye, Martin and Kennedy, Brian and Quevedo, Wilson and Schlotter, William F. and Dakovski, Georgi L. and Minitti, Michael P. and Hoffmann, Matthias C. and Mitra, Ankush and Moeller, Stefan P. and Nordlund, Dennis and Zhang, Wenkai and Liang, Huiyang W. and Kunnus, Kristian and Kubicek, Katharina and Techert, Simone A. and Lundberg, Marcus and Wernet, Philippe and Gaffney, Kelly and Odelius, Michael and F{\"o}hlisch, Alexander}, title = {Disentangling Transient Charge Density and Metal-Ligand Covalency in Photoexcited Ferricyanide with Femtosecond Resonant Inelastic Soft X-ray Scattering}, series = {The journal of physical chemistry letters}, volume = {9}, journal = {The journal of physical chemistry letters}, number = {12}, publisher = {American Chemical Society}, address = {Washington}, issn = {1948-7185}, doi = {10.1021/acs.jpclett.8b01429}, pages = {3538 -- 3543}, year = {2018}, abstract = {Soft X-ray spectroscopies are ideal probes of the local valence electronic structure of photocatalytically active metal sites. Here, we apply the selectivity of time resolved resonant inelastic X-ray scattering at the iron L-edge to the transient charge distribution of an optically excited charge-transfer state in aqueous ferricyanide. Through comparison to steady-state spectra and quantum chemical calculations, the coupled effects of valence-shell closing and ligand-hole creation are experimentally and theoretically disentangled and described in terms of orbital occupancy, metal-ligand covalency, and ligand field splitting, thereby extending established steady-state concepts to the excited-state domain. pi-Back-donation is found to be mainly determined by the metal site occupation, whereas the ligand hole instead influences sigma-donation. Our results demonstrate how ultrafast resonant inelastic X-ray scattering can help characterize local charge distributions around catalytic metal centers in short-lived charge-transfer excited states, as a step toward future rationalization and tailoring of photocatalytic capabilities of transition-metal complexes.}, language = {en} } @article{DippongCarlLenzetal.2017, author = {Dippong, Martin and Carl, Peter and Lenz, Christine and Schenk, J{\"o}rg A. and Hoffmann, Katrin and Schwaar, Timm and Schneider, Rudolf J. and Kuhne, Maren}, title = {Hapten-Specific Single-Cell Selection of Hybridoma Clones by Fluorescence-Activated Cell Sorting for the Generation of Monoclonal Antibodies}, series = {Analytical chemistry}, volume = {89}, journal = {Analytical chemistry}, publisher = {American Chemical Society}, address = {Washington}, issn = {0003-2700}, doi = {10.1021/acs.analchem.6b04569}, pages = {4007 -- 4012}, year = {2017}, language = {en} } @article{Hoffmann2011, author = {Hoffmann, Jan Martin}, title = {Die Pflicht der Staaten zur {\"U}bernahme der Rechte der Europ{\"a}ischen Menschenrechtskonvention in das innerstaatliche Recht}, series = {MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen}, volume = {16}, journal = {MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen}, number = {2}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1434-2820}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-60793}, pages = {129 -- 148}, year = {2011}, abstract = {Inhalt: - I. Einf{\"u}hrung - II. Verpflichtung zur {\"U}bernahme v{\"o}lkerrechtlicher Vertr{\"a}ge in das nationale Recht - III. Pflicht zur {\"U}bernahme der EMRK in das nationale Recht - IV. Besonderheit: Sp{\"a}tere {\"U}bung als quasi-authentische Interpretation - V. Ergebnis}, language = {de} } @book{SiehrKernHoffmannetal.2016, author = {Siehr, Karl-Heinz and Kern, Friederike and Hoffmann, Michael and Großbr{\"o}hmer, Christoph and M{\"u}hlbauer, Evelyn and Berner, Elisabeth and Leubner, Martin and Friese, Antonia and Preis, Matthias and Josting, Petra and H{\"o}fner, Marion and Schepe, Kerstin}, title = {Sport als Thema im Deutschunterricht}, editor = {Kern, Friederike and Siehr, Karl-Heinz}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-381-7}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-95307}, publisher = {Universit{\"a}t Potsdam}, year = {2016}, abstract = {Ein Deutschunterricht, der die Alltags- und Medienkultur der Sch{\"u}ler und Sch{\"u}lerinnen ernst nimmt, darf Sporttexte nicht unber{\"u}cksichtigt lassen. Zu sehr ist der Sport in all seinen Facetten Teil der Lebenswelt vieler Sch{\"u}lerinnen und Sch{\"u}ler geworden. Die Frage ist nicht mehr, ob der Deutschunterricht darauf zu reagieren hat, die Frage ist vielmehr, wie er dies tun und welche Sporttexte er dabei nutzen kann. Auch wenn die Suche nach sinnvollen Bez{\"u}gen zwischen Sport und Deutschunterricht schon seit l{\"a}ngerem intensiv betrieben wird, offenbart das vielschichtige Kulturph{\"a}nomen „Sport" immer wieder neue interessante Seiten, die es lohnen, fachdidaktisch behandelt zu werden. Die zehn Beitr{\"a}ge in diesem Band verstehen sich als Unterrichtsanregungen f{\"u}r den kompetenzorientierten Deutschunterricht. Sie bedienen Betrachtungen zum Sport aus literarischer, sprachlicher und medialer Perspektive. Die theoretisch-begrifflichen Aspekte der jeweiligen Themen werden soweit behandelt, wie sie f{\"u}r das Verst{\"a}ndnis erforderlich sind. Im Zentrum vieler Beitr{\"a}ge stehen Unterrichtsszenarien mit kommentierten Texten und Aufgaben, die f{\"u}r die Unterrichtsvorbereitung oder f{\"u}r den Unterricht selbst genutzt werden k{\"o}nnen.}, language = {de} } @article{ActisAgnettaAharonianetal.2011, author = {Actis, M. and Agnetta, G. and Aharonian, Felix A. and Akhperjanian, A. G. and Aleksic, J. and Aliu, E. and Allan, D. and Allekotte, I. and Antico, F. and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Arnaldi, H. and Artmann, S. and Asano, K. and Asorey, H. G. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balis, D. and Bamba, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and de Almeida, U. Barres and Barrio, J. A. and Basso, S. and Bastieri, D. and Bauer, C. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Becker, J. and Beckmann, Volker and Bednarek, W. and Behera, B. and Beilicke, M. and Belluso, M. and Benallou, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernardino, T. and Bernl{\"o}hr, K. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Blake, S. and Blanch Bigas, O. and Bobkov, A. A. and Bogacz, L. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Borkowski, Janett and Botner, O. and Bottani, A. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Brun, Pierre and Brunetti, L. and Buckley, H. and Bugaev, V. and Buehler, R. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Canestrari, R. and Cantu, S. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casiraghi, M. and Castarede, H. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, B. and Cerruti, M. and Chadwick, M. and Chiang, J. and Chikawa, M. and Cieslar, M. and Ciesielska, M. and Cillis, A. N. and Clerc, C. and Colin, P. and Colome, J. and Compin, M. and Conconi, P. and Connaughton, V. and Conrad, Jan and Contreras, J. L. and Coppi, P. and Corlier, M. and Corona, P. and Corpace, O. and Corti, D. and Cortina, J. and Costantini, H. and Cotter, G. and Courty, B. and Couturier, S. and Covino, S. and Croston, J. and Cusumano, G. and Daniel, M. K. and Dazzi, F. and Deangelis, A. and de Cea del Pozo, E. and Dal Pino, E. M. de Gouveia and de Jager, O. and de la Calle Perez, I. and De La Vega, G. and De Lotto, B. and de Naurois, M. and Wilhelmi, E. de Ona and de Souza, V. and Decerprit, B. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Dettlaff, T. and Di Paolo, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickinson, H. and Digel, S. W. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Domainko, W. and Dorner, D. and Doro, M. and Dournaux, J. -L. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Durand, D. and Dyks, J. and Dyrda, M. and Edy, E. and Egberts, Kathrin and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Enomoto, R. and Ernenwein, J. -P. and Errando, M. and Etchegoyen, A. and Falcone, A. D. and Farakos, K. and Farnier, C. and Federici, S. and Feinstein, F. and Ferenc, D. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. P. and Firpo, R. and Florin, D. and Foehr, C. and Fokitis, E. and Font, Ll. and Fontaine, G. and Fontana, A. and Foerster, A. and Fortson, L. and Fouque, N. and Fransson, C. and Fraser, G. W. and Fresnillo, L. and Fruck, C. and Fujita, Y. and Fukazawa, Y. and Funk, S. and Gaebele, W. and Gabici, S. and Gadola, A. and Galante, N. and Gallant, Y. and Garcia, B. and Garcia Lopez, R. J. and Garrido, D. and Garrido, L. and Gascon, D. and Gasq, C. and Gaug, M. and Gaweda, J. and Geffroy, N. and Ghag, C. and Ghedina, A. and Ghigo, M. and Gianakaki, E. and Giarrusso, S. and Giavitto, G. and Giebels, B. and Giro, E. and Giubilato, P. and Glanzman, T. and Glicenstein, J. -F. and Gochna, M. and Golev, V. and Gomez Berisso, M. and Gonzalez, A. and Gonzalez, F. and Granena, F. and Graciani, R. and Granot, J. and Gredig, R. and Green, A. and Greenshaw, T. and Grimm, O. and Grube, J. and Grudzinska, M. and Grygorczuk, J. and Guarino, V. and Guglielmi, L. and Guilloux, F. and Gunji, S. and Gyuk, G. and Hadasch, D. and Haefner, D. and Hagiwara, R. and Hahn, J. and Hallgren, A. and Hara, S. and Hardcastle, M. J. and Hassan, T. and Haubold, T. and Hauser, M. and Hayashida, M. and Heller, R. and Henri, G. and Hermann, G. and Herrero, A. and Hinton, James Anthony and Hoffmann, D. and Hofmann, W. and Hofverberg, P. and Horns, D. and Hrupec, D. and Huan, H. and Huber, B. and Huet, J. -M. and Hughes, G. and Hultquist, K. and Humensky, T. B. and Huppert, J. -F. and Ibarra, A. and Illa, J. M. and Ingjald, J. and Inoue, S. and Inoue, Y. and Ioka, K. and Jablonski, C. and Jacholkowska, A. and Janiak, M. and Jean, P. and Jensen, H. and Jogler, T. and Jung, I. and Kaaret, P. and Kabuki, S. and Kakuwa, J. and Kalkuhl, C. and Kankanyan, R. and Kapala, M. and Karastergiou, A. and Karczewski, M. and Karkar, S. and Karlsson, N. and Kasperek, J. and Katagiri, H. and Katarzynski, K. and Kawanaka, N. and Kedziora, B. and Kendziorra, E. and Khelifi, B. and Kieda, D. and Kifune, T. and Kihm, T. and Klepser, S. and Kluzniak, W. and Knapp, J. and Knappy, A. R. and Kneiske, T. and Knoedlseder, J. and Koeck, F. and Kodani, K. and Kohri, K. and Kokkotas, K. and Komin, N. and Konopelko, A. and Kosack, K. and Kossakowski, R. and Kostka, P. and Kotula, J. and Kowal, G. and Koziol, J. and Kraehenbuehl, T. and Krause, J. and Krawczynski, H. and Krennrich, F. and Kretzschmann, A. and Kubo, H. and Kudryavtsev, V. A. and Kushida, J. and La Barbera, N. and La Parola, V. and La Rosa, G. and Lopez, A. and Lamanna, G. and Laporte, P. and Lavalley, C. and Le Flour, T. and Le Padellec, A. and Lenain, J. -P. and Lessio, L. and Lieunard, B. and Lindfors, E. and Liolios, A. and Lohse, T. and Lombardi, S. and Lopatin, A. and Lorenz, E. and Lubinski, P. and Luz, O. and Lyard, E. and Maccarone, M. C. and Maccarone, T. and Maier, G. and Majumdar, P. and Maltezos, S. and Malkiewicz, P. and Mana, C. and Manalaysay, A. and Maneva, G. and Mangano, A. and Manigot, P. and Marin, J. and Mariotti, M. and Markoff, S. and Martinez, G. and Martinez, M. and Mastichiadis, A. and Matsumoto, H. and Mattiazzo, S. and Mazin, D. and McComb, T. J. L. and McCubbin, N. and McHardy, I. and Medina, C. and Melkumyan, D. and Mendes, A. and Mertsch, P. and Meucci, M. and Michalowski, J. and Micolon, P. and Mineo, T. and Mirabal, N. and Mirabel, F. and Miranda, J. M. and Mirzoyan, R. and Mizuno, T. and Moal, B. and Moderski, R. and Molinari, E. and Monteiro, I. and Moralejo, A. and Morello, C. and Mori, K. and Motta, G. and Mottez, F. and Moulin, Emmanuel and Mukherjee, R. and Munar, P. and Muraishi, H. and Murase, K. and Murphy, A. Stj. and Nagataki, S. and Naito, T. and Nakamori, T. and Nakayama, K. and Naumann, C. L. and Naumann, D. and Nayman, P. and Nedbal, D. and Niedzwiecki, A. and Niemiec, J. and Nikolaidis, A. and Nishijima, K. and Nolan, S. J. and Nowak, N. and O'Brien, P. T. and Ochoa, I. and Ohira, Y. and Ohishi, M. and Ohka, H. and Okumura, A. and Olivetto, C. and Ong, R. A. and Orito, R. and Orr, M. and Osborne, J. P. and Ostrowski, M. and Otero, L. and Otte, A. N. and Ovcharov, E. and Oya, I. and Ozieblo, A. and Paiano, S. and Pallota, J. and Panazol, J. L. and Paneque, D. and Panter, M. and Paoletti, R. and Papyan, G. and Paredes, J. M. and Pareschi, G. and Parsons, R. D. and Arribas, M. Paz and Pedaletti, G. and Pepato, A. and Persic, M. and Petrucci, P. O. and Peyaud, B. and Piechocki, W. and Pita, S. and Pivato, G. and Platos, L. and Platzer, R. and Pogosyan, L. and Pohl, Martin and Pojmanski, G. and Ponz, J. D. and Potter, W. and Prandini, E. and Preece, R. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quel, E. and Quirrenbach, A. and Rajda, P. and Rando, R. and Rataj, M. and Raue, M. and Reimann, C. and Reimann, O. and Reimer, A. and Reimer, O. and Renaud, M. and Renner, S. and Reymond, J. -M. and Rhode, W. and Ribo, M. and Ribordy, M. and Rico, J. and Rieger, F. and Ringegni, P. and Ripken, J. and Ristori, P. and Rivoire, S. and Rob, L. and Rodriguez, S. and Roeser, U. and Romano, Patrizia and Romero, G. E. and Rosier-Lees, S. and Rovero, A. C. and Roy, F. and Royer, S. and Rudak, B. and Rulten, C. B. and Ruppel, J. and Russo, F. and Ryde, F. and Sacco, B. and Saggion, A. and Sahakian, V. and Saito, K. and Saito, T. and Sakaki, N. and Salazar, E. and Salini, A. and Sanchez, F. and Sanchez Conde, M. A. and Santangelo, A. and Santos, E. M. and Sanuy, A. and Sapozhnikov, L. and Sarkar, S. and Scalzotto, V. and Scapin, V. and Scarcioffolo, M. and Schanz, T. and Schlenstedt, S. and Schlickeiser, R. and Schmidt, T. and Schmoll, J. and Schroedter, M. and Schultz, C. and Schultze, J. and Schulz, A. and Schwanke, U. and Schwarzburg, S. and Schweizer, T. and Seiradakis, J. and Selmane, S. and Seweryn, K. and Shayduk, M. and Shellard, R. C. and Shibata, T. and Sikora, M. and Silk, J. and Sillanpaa, A. and Sitarek, J. and Skole, C. and Smith, N. and Sobczynska, D. and Sofo Haro, M. and Sol, H. and Spanier, F. and Spiga, D. and Spyrou, S. and Stamatescu, V. and Stamerra, A. and Starling, R. L. C. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steiner, S. and Stergioulas, N. and Sternberger, R. and Stinzing, F. and Stodulski, M. and Straumann, U. and Suarez, A. and Suchenek, M. and Sugawara, R. and Sulanke, K. H. and Sun, S. and Supanitsky, A. D. and Sutcliffe, P. and Szanecki, M. and Szepieniec, T. and Szostek, A. and Szymkowiak, A. and Tagliaferri, G. and Tajima, H. and Takahashi, H. and Takahashi, K. and Takalo, L. and Takami, H. and Talbot, R. G. and Tam, P. H. and Tanaka, M. and Tanimori, T. and Tavani, M. and Tavernet, J. -P. and Tchernin, C. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Tenzer, C. and Terada, Y. and Terrier, R. and Teshima, M. and Testa, V. and Tibaldo, L. and Tibolla, O. and Tluczykont, M. and Peixoto, C. J. Todero and Tokanai, F. and Tokarz, M. and Toma, K. and Torres, D. F. and Tosti, G. and Totani, T. and Toussenel, F. and Vallania, P. and Vallejo, G. and van der Walt, J. and van Eldik, C. and Vandenbroucke, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. V. and Vegas, I. and Venter, L. and Vercellone, S. and Veyssiere, C. and Vialle, J. P. and Videla, M. and Vincent, P. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and Volpe, F. and Von Gunten, H. P. and Vorobiov, S. and Wagner, S. and Wagner, R. M. and Wagner, B. and Wakely, S. P. and Walter, P. and Walter, R. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wilkinson, M. I. and Williams, D. A. and Winde, M. and Wischnewski, R. and Wisniewski, L. and Wolczko, A. and Wood, M. and Xiong, Q. and Yamamoto, T. and Yamaoka, K. and Yamazaki, R. and Yanagita, S. and Yoffo, B. and Yonetani, M. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zagdanski, A. and Zajczyk, A. and Zdziarski, A. and Zech, Alraune and Zietara, K. and Ziolkowski, P. and Zitelli, V. and Zychowski, P.}, title = {Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy}, series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, volume = {32}, journal = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, number = {3}, publisher = {Springer}, address = {Dordrecht}, organization = {CTA Consortium}, issn = {0922-6435}, doi = {10.1007/s10686-011-9247-0}, pages = {193 -- 316}, year = {2011}, abstract = {Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.}, language = {en} } @article{AbramowskiAceroAharonianetal.2012, author = {Abramowski, Attila and Acero, F. and Aharonian, Felix A. and Akhperjanian, A. G. and Anton, Gisela and Balzer, Arnim and Barnacka, Anna and de Almeida, U. 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S. and Pichel, A. and Pohl, Martin and Prokoph, H. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Roache, E. and Rose, H. J. and Ruppel, J. and Schroedter, M. and Sembroski, G. H. and Sentuerk, G. D. and Telezhinsky, Igor O. and Tesic, G. and Theiling, M. and Thibadeau, S. and Varlotta, A. and Vassiliev, V. V. and Vivier, M. and Wakely, S. P. and Weekes, T. C. and Williams, D. A. and Zitzer, B. and de Almeida, U. Barres and Cara, M. and Casadio, C. and Cheung, C. C. and McConville, W. and Davies, F. and Doi, A. and Giovannini, G. and Giroletti, M. and Hada, K. and Hardee, P. and Harris, D. E. and Junor, W. and Kino, M. and Lee, N. P. and Ly, C. and Madrid, J. and Massaro, F. and Mundell, C. G. and Nagai, H. and Perlman, E. S. and Steele, I. A. and Walker, R. C. and Wood, D. L.}, title = {The 2010 very high energy gamma-ray flare and 10 years ofmulti-wavelength oservations of M 87}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {746}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, organization = {HESS Collaboration, MAGIC Collaboration, VERITAS Collaboration}, issn = {0004-637X}, doi = {10.1088/0004-637X/746/2/151}, pages = {18}, year = {2012}, abstract = {The giant radio galaxy M 87 with its proximity (16 Mpc), famous jet, and very massive black hole ((3-6) x 10(9) M-circle dot) provides a unique opportunity to investigate the origin of very high energy (VHE; E > 100 GeV) gamma-ray emission generated in relativistic outflows and the surroundings of supermassive black holes. M 87 has been established as a VHE gamma-ray emitter since 2006. The VHE gamma-ray emission displays strong variability on timescales as short as a day. In this paper, results from a joint VHE monitoring campaign on M 87 by the MAGIC and VERITAS instruments in 2010 are reported. During the campaign, a flare at VHE was detected triggering further observations at VHE (H.E.S.S.), X-rays (Chandra), and radio (43 GHz Very Long Baseline Array, VLBA). The excellent sampling of the VHE gamma-ray light curve enables one to derive a precise temporal characterization of the flare: the single, isolated flare is well described by a two-sided exponential function with significantly different flux rise and decay times of tau(rise)(d) = (1.69 +/- 0.30) days and tau(decay)(d) = (0.611 +/- 0.080) days, respectively. While the overall variability pattern of the 2010 flare appears somewhat different from that of previous VHE flares in 2005 and 2008, they share very similar timescales (similar to day), peak fluxes (Phi(>0.35 TeV) similar or equal to (1-3) x 10(-11) photons cm(-2) s(-1)), and VHE spectra. VLBA radio observations of 43 GHz of the inner jet regions indicate no enhanced flux in 2010 in contrast to observations in 2008, where an increase of the radio flux of the innermost core regions coincided with a VHE flare. On the other hand, Chandra X-ray observations taken similar to 3 days after the peak of the VHE gamma-ray emission reveal an enhanced flux from the core (flux increased by factor similar to 2; variability timescale <2 days). The long-term (2001-2010) multi-wavelength (MWL) light curve of M 87, spanning from radio to VHE and including data from Hubble Space Telescope, Liverpool Telescope, Very Large Array, and European VLBI Network, is used to further investigate the origin of the VHE gamma-ray emission. No unique, common MWL signature of the three VHE flares has been identified. In the outer kiloparsec jet region, in particular in HST-1, no enhanced MWL activity was detected in 2008 and 2010, disfavoring it as the origin of the VHE flares during these years. Shortly after two of the three flares (2008 and 2010), the X-ray core was observed to be at a higher flux level than its characteristic range (determined from more than 60 monitoring observations: 2002-2009). In 2005, the strong flux dominance of HST-1 could have suppressed the detection of such a feature. Published models for VHE gamma-ray emission from M 87 are reviewed in the light of the new data.}, language = {en} } @article{GolleGranacherHoffmannetal.2014, author = {Golle, Kathleen and Granacher, Urs and Hoffmann, Martin and Wick, Ditmar and M{\"u}hlbauer, Thomas}, title = {Effect of living area and sports club participation on physical fitness in children: a 4 year longitudinal study}, series = {BMC public health}, volume = {14}, journal = {BMC public health}, publisher = {BioMed Central}, address = {London}, issn = {1471-2458}, doi = {10.1186/1471-2458-14-499}, pages = {8}, year = {2014}, abstract = {Background: Cross-sectional studies detected associations between physical fitness, living area, and sports participation in children. Yet, their scientific value is limited because the identification of cause-and-effect relationships is not possible. In a longitudinal approach, we examined the effects of living area and sports club participation on physical fitness development in primary school children from classes 3 to 6. Methods: One-hundred and seventy-two children (age: 9-12 years; sex: 69 girls, 103 boys) were tested for their physical fitness (i.e., endurance [9-min run], speed [50-m sprint], lower- [triple hop] and upper-extremity muscle strength [1-kg ball push], flexibility [stand-and-reach], and coordination [star coordination run]). Living area (i.e., urban or rural) and sports club participation were assessed using parent questionnaire. Results: Over the 4 year study period, urban compared to rural children showed significantly better performance development for upper- (p = 0.009, ES = 0.16) and lower-extremity strength (p < 0.001, ES = 0.22). Further, significantly better performance development were found for endurance (p = 0.08, ES = 0.19) and lower-extremity strength (p = 0.024, ES = 0.23) for children continuously participating in sports clubs compared to their non-participating peers. Conclusions: Our findings suggest that sport club programs with appealing arrangements appear to represent a good means to promote physical fitness in children living in rural areas.}, language = {en} } @misc{GolleGranacherHoffmannetal.2014, author = {Golle, Kathleen and Granacher, Urs and Hoffmann, Martin and Wick, Ditmar and M{\"u}hlbauer, Thomas}, title = {Effect of living area and sports club participation on physical fitness in children}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-401418}, pages = {8}, year = {2014}, abstract = {Background: Cross-sectional studies detected associations between physical fitness, living area, and sports participation in children. Yet, their scientific value is limited because the identification of cause-and-effect relationships is not possible. In a longitudinal approach, we examined the effects of living area and sports club participation on physical fitness development in primary school children from classes 3 to 6. Methods: One-hundred and seventy-two children (age: 9-12 years; sex: 69 girls, 103 boys) were tested for their physical fitness (i.e., endurance [9-min run], speed [50-m sprint], lower- [triple hop] and upper-extremity muscle strength [1-kg ball push], flexibility [stand-and-reach], and coordination [star coordination run]). Living area (i.e., urban or rural) and sports club participation were assessed using parent questionnaire. Results: Over the 4 year study period, urban compared to rural children showed significantly better performance development for upper- (p = 0.009, ES = 0.16) and lower-extremity strength (p < 0.001, ES = 0.22). Further, significantly better performance development were found for endurance (p = 0.08, ES = 0.19) and lower-extremity strength (p = 0.024, ES = 0.23) for children continuously participating in sports clubs compared to their non-participating peers. Conclusions: Our findings suggest that sport club programs with appealing arrangements appear to represent a good means to promote physical fitness in children living in rural areas.}, language = {en} }