@article{ThielRomanoSchwarzetal.2004,
  author    = {Thiel, M. and Romano, Maria Carmen and Schwarz, Udo and Kurths, J{\"u}rgen and Timmer, Jens},
  title     = {Surrogate-based hypothesis test without surrogates},
  issn      = {0218-1274},
  year      = {2004},
  abstract  = {Fourier surrogate data are artificially generated time series, that - based on a resampling scheme - share the linear properties with an observed time series. In this paper we study a statistical surrogate hypothesis test to detect deviations from a linear Gaussian process with respect to asymmetry in time (Q-statistic). We apply this test to a Fourier representable function and obtain a representation of the asymmetry in time of the sample data, a characteristic for nonlinear processes, and the significance in terms of the Fourier coefficients. The main outcome is that we calculate the expected value of the mean and the standard deviation of the asymmetries of the surrogate data analytically and hence, no surrogates have to be generated. To illustrate the results we apply our method to the saw tooth function, the Lorenz system and to measured X-ray data of Cygnus X-1},
  language  = {en}
}
@misc{SchwarzLossowKoppetal.2019,
  author    = {Schwarz, Maria and Lossow, Kristina and Kopp, Johannes F. and Schwerdtle, Tanja and Kipp, Anna Patricia},
  title     = {Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1081},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-47287},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472873},
  pages     = {20},
  year      = {2019},
  abstract  = {Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2 pathway. Vice versa, Nrf2 target genes belong to the group of transport and metal binding proteins. In order to investigate whether Nrf2 directly regulates the systemic trace element status, we used mice to study the effect of a constitutive, whole-body Nrf2 knockout on the systemic status of Cu, Zn, Fe, and Se. As the loss of selenoproteins under Se-deprived conditions has been described to further enhance Nrf2 activity, we additionally analyzed the combination of Nrf2 knockout with feeding diets that provide either suboptimal, adequate, or supplemented amounts of Se. Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma. However, aside from Fe, the other three trace elements were only marginally modulated in an Nrf2-dependent manner. Selenium deficiency mainly resulted in increased plasma Zn levels. One putative mediator could be the metal regulatory transcription factor 1, which was up-regulated with an increasing Se supply and downregulated in Se-supplemented Nrf2 knockout mice.},
  language  = {en}
}
@misc{JobstEtteMartiMarcoetal.2008,
  author    = {Jobst, Anne and Ette, Ottmar and Mart{\´i} Marco, Mar{\´i}a Rosario and M{\"u}ller, Tom and Pr{\"a}ßler, Ulrich and Thiemer-Sachse, Ursula and Biermann, Kurt-Reinhard and Schwarz, Ingo},
  title     = {HiN : Alexander von Humboldt im Netz},
  volume    = {IX},
  number    = {17},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/hinvol9iss172008},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42446},
  pages     = {63},
  year      = {2008},
  abstract  = {Inhalt: - Hinweis auf die elektronischen Ressourcen, bereitgestellt von der Alexander von-Humboldt-Forschungsstelle der Berlin-Brandenburgischen Akademie der Wissenschaften - Anne Jobst: „wie man die Gabe aplicirt" : der Briefwechsel zwischen Humboldt und Ehrenberg, ein Beispiel - Ottmar Ette: Hallar e inventar un p{\´u}blico. Nuevos proyectos editoriales acerca de la obra de Alexander von Humboldt - Mar{\´i}a Rosario Mart{\´i} Marco: La figura del bot{\´a}nico Valenciano Antonio Jos{\´e} Cavanilles en su relaci{\´o}n cient{\´i}fica con Humboldt y los bot{\´a}nicos alemanes - Tom M{\"u}ller: Roger Bacon in der Sicht Alexander von Humboldts Ulrich P{\"a}ßler: Alexander von Humboldt und die transnationale Wissenschaftskommunikation im 19. Jahrhundert - Ursula Thiemer-Sachse: La visi{\´o}n de Alejandro de Humboldt de la situaci{\´o}n social y cultural de los ind{\´i}genas mexicanos contempor{\´a}neos, tal como fue reflejada en su diario de iaje y en el "Ensayo Pol{\´i}tico del Reino de la Nueva Espa{\~n}a" - Kurt-R. Biermann/Ingo Schwarz: Warum bezeichnete sich Alexander von Humboldt als DER ALTE VOM BERGE (Vecchio della Montagna)?},
  language  = {mul}
}
@article{SchwarzLossowKoppetal.2019,
  author    = {Schwarz, Maria and Lossow, Kristina and Kopp, Johannes Florian and Schwerdtle, Tanja and Kipp, Anna Patricia},
  title     = {Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper},
  series = {Nutrients},
  volume    = {11},
  journal   = {Nutrients},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6643},
  doi       = {10.3390/nu11092112},
  pages     = {18},
  year      = {2019},
  abstract  = {Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2 pathway. Vice versa, Nrf2 target genes belong to the group of transport and metal binding proteins. In order to investigate whether Nrf2 directly regulates the systemic trace element status, we used mice to study the effect of a constitutive, whole-body Nrf2 knockout on the systemic status of Cu, Zn, Fe, and Se. As the loss of selenoproteins under Se-deprived conditions has been described to further enhance Nrf2 activity, we additionally analyzed the combination of Nrf2 knockout with feeding diets that provide either suboptimal, adequate, or supplemented amounts of Se. Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma. However, aside from Fe, the other three trace elements were only marginally modulated in an Nrf2-dependent manner. Selenium deficiency mainly resulted in increased plasma Zn levels. One putative mediator could be the metal regulatory transcription factor 1, which was up-regulated with an increasing Se supply and downregulated in Se-supplemented Nrf2 knockout mice.},
  language  = {en}
}
@article{FinkeWinkelbeinerLossowetal.2020,
  author    = {Finke, Hannah and Winkelbeiner, Nicola Lisa and Lossow, Kristina and Hertel, Barbara and Wandt, Viktoria Klara Veronika and Schwarz, Maria and Pohl, Gabriele and Kopp, Johannes Florian and Ebert, Franziska and Kipp, Anna Patricia and Schwerdtle, Tanja},
  title     = {Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice},
  series = {Molecular nutrition \& food research},
  volume    = {64},
  journal   = {Molecular nutrition \& food research},
  number    = {16},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1613-4125},
  doi       = {10.1002/mnfr.202000325},
  year      = {2020},
  abstract  = {Scope: Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate for several TEs, concurrently. Therefore, the impact of a suboptimal supply of iron, zinc, copper, iodine, and selenium on the TE status, health parameters, epigenetics, and genomic stability in mice are studied. Methods and results: Male mice receive reduced or adequate amounts of TEs for 9 weeks. The TE status is analyzed mass-spectrometrically in serum and different tissues. Furthermore, gene and protein expression of TE biomarkers are assessed with focus on liver. Iron concentrations are most sensitive toward a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of iron-related genes. Reduced TE supply results in smaller weight gain but higher spleen and heart weights. Additionally, inflammatory mediators in serum and liver are increased together with hepatic genomic instability. However, global DNA (hydroxy)methylation is unaffected by the TE modulation. Conclusion: Despite homeostatic regulation of most TEs in response to a low intake, this condition still has substantial effects on health parameters. It appears that the liver and immune system react particularly sensitive toward changes in TE intake. The reduced Fe status might be the primary driver for the observed effects.},
  language  = {en}
}
@misc{KnoblochSchwarzLubrichetal.2003,
  author    = {Knobloch, Eberhard and Schwarz, Ingo and Lubrich, Oliver and Siegel, Eva-Maria and Weigl, Engelhard},
  title     = {HiN : Alexander von Humboldt im Netz},
  volume    = {IV},
  number    = {7},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2568-3543},
  doi       = {10.18443/hinvol4iss072003},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-424398},
  pages     = {62},
  year      = {2003},
  abstract  = {Inhalt: - Eberhard Knobloch und Ingo Schwarz: Alexander von Humboldt und Hector Berlioz - Oliver Lubrich: „[M]on extr{\^e}me r{\´e}pugnance {\`a} {\´e}crire la relation de mon voyage" - Alejandro de Humboldt deconstruye la relaci{\´o}n de viaje - Eva-Maria Siegel: Repr{\"a}sentation und Augenschein. Organisation des Wissens und Wahrnehmung des Fremden um 1800 am Beispiel der Reiseberichte und -tageb{\"u}cher Alexander von Humboldts - Engelhard Weigl: Acclimatization: The Schomburgk brothers in South Australia},
  language  = {de}
}
@article{KomalapriyaRomanoBlascoThieletal.2009,
  author    = {Komalapriya, Chandrasekaran and Romano Blasco, Maria Carmen and Thiel, Marco and Schwarz, Udo and Kurths, J{\"u}rgen and Simonotto, Jennifer and Furman, Michael and Ditto, William L. and Carney, Paul R.},
  title     = {Analysis of high-resulution microelectrode EEG recordings in an animal model of spontaneous limbic seizures},
  issn      = {0218-1274},
  doi       = {10.1142/S0218127409023226},
  year      = {2009},
  language  = {en}
}
@article{RomanoThielSchwarzetal.2001,
  author    = {Romano, Maria Carmen and Thiel, Marco and Schwarz, Udo and Kurths, J{\"u}rgen and Lange, Holger and Hauhs, M.},
  title     = {Conceptual model of runoff from a forested catchment},
  year      = {2001},
  abstract  = {We investigate the relationship between precipitation and runoff data from a small forested catchment in the Harz mountains (Germany). For this purpose, we develop a conceptual model including memory effects to predict the runoff signal using the precipitation data as input. An enhanced variant of the model also includes air temperature as input variable. We show in terms of correlation functions that this model describes main dynamical properties of the runoff, especially the delay between rain event and runoff response as the annual persistence in the runoff data.},
  language  = {en}
}
@article{ThielRomanoSchwarzetal.2001,
  author    = {Thiel, Marco and Romano, Maria Carmen and Schwarz, Udo and Kurths, J{\"u}rgen and Hasinger, G{\"u}nther and Belloni, Tomaso},
  title     = {Nonlinear Time series analysis of the X-ray flux of compact objects},
  issn      = {0004-640x},
  year      = {2001},
  abstract  = {We analyse the X-ray light curves of compact objects using linear and nonlinear time series analysis methods. A Power Density Spectrum (PDS) describes the overall second order properties of the observed data well. To look beyond we propose the nonlinear Q-statistic to detect an asymmetry of the time series. This allows us to find relevant time scales. This method even grants a subclassification of the known states of X-ray sources.},
  language  = {en}
}
@article{WhiteleyHaugKleinetal.2017,
  author    = {Whiteley, Liam and Haug, Maria and Klein, Kristina and Willmann, Matthias and Bohn, Erwin and Chiantia, Salvatore and Schwarz, Sandra},
  title     = {Cholesterol and host cell surface proteins contribute to cell-cell fusion induced by the Burkholderia type VI secretion system 5},
  series = {PLoS one},
  volume    = {12},
  journal   = {PLoS one},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0185715},
  pages     = {16},
  year      = {2017},
  abstract  = {Following escape into the cytoplasm of host cells, Burkholderia pseudomallei and the related species Burkholderia thailandensis employ the type VI secretion system 5 ( T6SS-5) to induce plasma membrane fusion with an adjacent host cell. This process leads to the formation of multinucleated giant cells and facilitates bacterial access to an uninfected host cell in a direct manner. Despite its importance in virulence, the mechanism of the T6SS-5 and the role of host cell factors in cell-cell fusion remain elusive. To date, the T6SS-5 is the only system of bacterial origin known to induce host-cell fusion. To gain insight into the nature of T6SS-5-stimulated membrane fusion, we investigated the contribution of cholesterol and proteins exposed on the host cell surface, which were shown to be critically involved in virus-mediated giant cell formation. In particular, we analyzed the effect of host cell surface protein and cholesterol depletion on the formation of multinucleated giant cells induced by B. thailandensis. Acute protease treatment of RAW264.7 macrophages during infection with B. thailandensis followed by agarose overlay assays revealed a strong reduction in the number of cell-cell fusions compared with EDTA treated cells. Similarly, proteolytic treatment of specifically infected donor cells or uninfected recipient cells significantly decreased multinucleated giant cell formation. Furthermore, modulating host cell cholesterol content by acute cholesterol depletion from cellular membranes by methyl-beta-cyclodextrin treatment or exogenous addition of cholesterol impaired the ability of B. thailandensis to induce cell-cell fusions. The requirement of physiological cholesterol levels suggests that the membrane organization or mechanical properties of the lipid bilayer influence the fusion process. Altogether, our data suggest that membrane fusion induced by B. pseudomallei and B. thailandensis involves a complex interplay between the T6SS-5 and the host cell.},
  language  = {en}
}
@misc{KraftDrozdowskaBroeringLeitneretal.2017,
  author    = {Kraft, Tobias and Drozdowska-Broering, Izabela and Leitner, Ulrike and Mikolajczyk, Aniela Maria and P{\"a}ßler, Ulrich and Schwarz, Ingo and Walravens, Hartmut and Werner, Petra},
  title     = {HiN : Alexander von Humboldt im Netz},
  series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies},
  volume    = {XVIII},
  journal   = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies},
  number    = {34},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/hinvol18iss342017},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395914},
  pages     = {171},
  year      = {2017},
  abstract  = {Inhalt: - Tobias Kraft: Die Berliner Edition Humboldt digital - Izabela Drozdowska-Broering: Alexander von Humboldt und die polnische Wissenschafts- und Kulturwelt - Ulrike Leitner: Sobre r{\´i}os y canales - Aspectos geogr{\´a}ficos y cartogr{\´a}ficos en el legado de Humboldt - Aniela Maria Mikolajczyk: Alexander von Humboldts Manuskript Isle de Cube. Antilles en g{\´e}n{\´e}ral in der Biblioteka Jagiellońska als Vorstufe des Essai politique sur l'{\^i}le de Cuba - Ulrich P{\"a}ßler: A Political Economy of Nature: Alexander von Humboldt's Essay on the Fluctuations in the Supplies of Gold - Ingo Schwarz: "Any American will always be welcome to the study of Alexander von Humboldt". Ein Besucher aus den Vereinigten Staaten von Amerika bei Alexander von Humboldt 1836 - Hartmut Walravens: Zu den von A. v. Humboldt aus Rußland mitgebrachten B{\"u}chern - Petra Werner: Franz Julius Ferdinand Meyen: gef{\"o}rdert und fr{\"u}hvollendet. Zwischen Poesie und totem Zoo - Ingo Schwarz: Nachtrag zu HiN XVII, 33 (2016) - Ingo Schwarz: Bernd K{\"o}lbel: Geologe und Alexander-von-Humboldt-Forscher},
  language  = {de}
}
@inproceedings{LossowSchwarzKoppetal.2021,
  author    = {Loßow, Kristina and Schwarz, Maria and Kopp, Johannes and Schwerdtle, Tanja and Kipp, Anna Patricia},
  title     = {Age- and sex-dependent changes of trace elements and redox parameters in mice},
  series = {Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research},
  volume    = {165},
  booktitle = {Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research},
  number    = {Suppl. 1},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {0891-5849},
  doi       = {10.1016/j.freeradbiomed.2020.12.346},
  pages     = {34},
  year      = {2021},
  language  = {en}
}
@misc{HauffeRathAgyapongetal.2022,
  author    = {Hauffe, Robert and Rath, Michaela and Agyapong, Wilson and Jonas, Wenke and Vogel, Heike and Schulz, Tim Julius and Schwarz, Maria and Kipp, Anna Patricia and Bl{\"u}her, Matthias and Kleinridders, Andr{\´e}},
  title     = {Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-56170},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-561709},
  pages     = {1 -- 16},
  year      = {2022},
  abstract  = {The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo.},
  language  = {en}
}
@article{HauffeRathAgyapongetal.2022,
  author    = {Hauffe, Robert and Rath, Michaela and Agyapong, Wilson and Jonas, Wenke and Vogel, Heike and Schulz, Tim Julius and Schwarz, Maria and Kipp, Anna Patricia and Bl{\"u}her, Matthias and Kleinridders, Andr{\´e}},
  title     = {Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling},
  series = {Antioxidants},
  volume    = {11},
  journal   = {Antioxidants},
  edition   = {5},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2076-3921},
  doi       = {10.3390/antiox11050862},
  pages     = {1 -- 16},
  year      = {2022},
  abstract  = {The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo.},
  language  = {en}
}
@article{AgtheKayserSchwarzetal.2023,
  author    = {Agthe, Maria and Kayser, Daniela Niesta and Schwarz, Sascha and Maner, Jon K.},
  title     = {Antecedents of the red-romance effect},
  series = {PLOS ONE / Public Library of Science},
  volume    = {18},
  journal   = {PLOS ONE / Public Library of Science},
  number    = {4},
  publisher = {PLOS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0284035},
  pages     = {19},
  year      = {2023},
  abstract  = {The color red has been implicated in a variety of social processes, including those involving mating. While previous research suggests that women sometimes wear red strategically to increase their attractiveness, the replicability of this literature has been questioned. The current research is a reasonably powered conceptual replication designed to strengthen this literature by testing whether women are more inclined to display the color red 1) during fertile (as compared with less fertile) days of the menstrual cycle, and 2) when expecting to interact with an attractive man (as compared with a less attractive man and with a control condition). Analyses controlled for a number of theoretically relevant covariates (relationship status, age, the current weather). Only the latter hypothesis received mixed support (mainly among women on hormonal birth control), whereas results concerning the former hypothesis did not reach significance. Women (N = 281) displayed more red when expecting to interact with an attractive man; findings did not support the prediction that women would increase their display of red on fertile days of the cycle. Findings thus suggested only mixed replicability for the link between the color red and psychological processes involving romantic attraction. They also illustrate the importance of further investigating the boundary conditions of color effects on everyday social processes.},
  language  = {en}
}