@article{MaiwaldJungaLangetal.2019, author = {Maiwald, Lisa Marie and Junga, Yvonne Marie and Lang, Thomas and Montini, Romina and Witth{\"o}ft, Michael and Heider, Jens and Schr{\"o}der, Annette and Weck, Florian}, title = {The role of therapist and patient in-session behavior for treatment outcome in exposure-based cognitive behavioral therapy for panic disorder with agoraphobia}, series = {Journal of clinical psychology}, volume = {75}, journal = {Journal of clinical psychology}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0021-9762}, doi = {10.1002/jclp.22738}, pages = {614 -- 626}, year = {2019}, abstract = {Objective There is a very limited amount of research on the relationship between therapist and patient in-session behavior and treatment outcome in cognitive behavioral therapy (CBT) for panic disorder with agoraphobia (PD/AG). Additionally, the findings tend to be inconclusive. This study investigates the association between therapist competence, adherence, patient interpersonal behavior, and therapeutic alliance and outcome in a low-control CBT setting by using comprehensive measures. Methods Twenty-six patients with PD/AG received 12 sessions of exposure-based CBT. With regard to the outcome, treatments were classified either as problematic or nonproblematic by means of distinct criteria. Two raters evaluated the in-session behavior. Results Patient interpersonal behavior was significantly associated with outcome at follow-up (r = 0.49). At posttreatment, the correlation did not reach significance ( r = 0.34). Competence, adherence, and alliance were not outcome associated. Conclusion The findings emphasize the need for therapists to pay particular attention to patients' interpersonal behavior during treatment.}, language = {en} } @article{MichalikOnichimowskaKernRiedeletal.2017, author = {Michalik-Onichimowska, Aleksandra and Kern, Simon and Riedel, Jens and Panne, Ulrich and King, Rudibert and Maiwald, Michael}, title = {"Click" analytics for "click" chemistry - A simple method for calibration-free evaluation of online NMR spectra}, series = {Journal of magnetic resonance}, volume = {277}, journal = {Journal of magnetic resonance}, publisher = {Elsevier}, address = {San Diego}, issn = {1090-7807}, doi = {10.1016/j.jmr.2017.02.018}, pages = {154 -- 161}, year = {2017}, abstract = {Driven mostly by the search for chemical syntheses under biocompatible conditions, so called "click" chemistry rapidly became a growing field of research. The resulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via comparably straightforward and robust analysis techniques possessing short set-up times. Here, we report on a fast and reliable calibration-free online NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement of H-1 spectra with a time interval of 20 s per spectrum, and a robust, fully automated algorithm to interpret the obtained data. As a proof-of-concept, the thiol-ene coupling between N-boc cysteine methyl ester and ally] alcohol was conducted in a variety of non-deuterated solvents while its time-resolved behaviour was characterized with step tracer experiments. Overlapping signals in online spectra during thiol-ene coupling could be deconvoluted with a spectral model using indirect hard modeling and were subsequently converted to either molar ratios (using a calibration free approach) or absolute concentrations (using 1-point calibration). For various solvents the kinetic constant k for pseudo-first order reaction was estimated to be 3.9 h(-1) at 25 degrees C. The obtained results were compared with direct integration of non-overlapping signals and showed good agreement with the implemented mass balance. (C) 2017 Elsevier Inc. All rights reserved.}, language = {en} } @article{HahnWeckWitthoeftetal.2022, author = {Hahn, Daniela and Weck, Florian and Witth{\"o}ft, Michael and Maiwald, Lisa Marie and Foral, Annika and K{\"u}hne, Franziska}, title = {Wie erleben Psychotherapeut_innen in Ausbildung ihre Selbsterfahrung?}, series = {Zeitschrift f{\"u}r Klinische Psychologie und Psychotherapie}, volume = {50}, journal = {Zeitschrift f{\"u}r Klinische Psychologie und Psychotherapie}, number = {2}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {1616-3443}, doi = {10.1026/1616-3443/a000626}, pages = {78 -- 89}, year = {2022}, abstract = {Background: Self-experiential work is a central component of psychotherapy training. However, research on this matter has not received a lot of attention. Objective: This study explores the conditions and effects of helpful self-experiential work. Method: We interviewed 14 psychotherapists in training using a semistructured interview guide and applied qualitative content analysis according to Mayring (2015). Results: Different characteristics were associated with helpful self-experiential work: characteristics of the instructor (e. g., implementation skills), organization, willingness of the trainees to learn, topics and methods applied, and a sustainable working atmosphere. Among the positive effects reported was the promotion of the trainees' interpersonal competencies. Furthermore, we found some side effects and negative impact (e. g.. exhaustion). Conclusions: We were able to extract conditions that can guide the execution of helpful self-experiential work and the effects of self-experiential work from the perspective of the trainees.}, language = {de} }