@article{AhnenAnsoldiAntonellietal.2018, author = {Ahnen, M. L. and Ansoldi, S. and Antonelli, L. A. and Arcaro, C. and Babie, A. and Banerjee, B. and Bangale, P. and de Almeida, U. Barres and Barrio, J. A. and Gonzalez, J. Becerra and Bednarek, W. and Bernardini, E. and Berti, A. and Biasuzzi, B. and Biland, A. and Blanch, O. and Bonnefoy, S. and Bonnoli, G. and Borracci, F. and Carosi, R. and Carosi, A. and Chatterjee, A. and Colin, P. and Colombo, E. and Contreras, J. L. and Cortina, J. and Covino, S. and Cumani, P. and Da Vela, P. and Dazzi, F. and De Angelis, A. and De Lotto, B. and Wilhelmi, E. de Ona and Di Pierro, F. and Doert, M. and Dominguez, A. and Prester, D. Dominis and Dorner, D. and Doro, M. and Einecke, S. and Glawion, D. Eisenacher and Elsaesser, D. and Engelkemeier, M. and Ramazani, V. Fallah and Fernandez-Barra, A. and Fidalgo, D. and Fonseca, M. V. and Font, L. and Fruck, C. and Galindo, D. and Lopez, R. J. Garcia and Garczarczyk, M. and Gaug, M. and Giammaria, P. and Godinovie, N. and Gora, D. and Griffiths, S. and Guberman, D. and Hadasch, D. and Hahn, A. and Hassan, T. and Hayashida, M. and Herrera, J. and Hose, J. and Hrupec, D. and Hughes, G. and Ishio, K. and Konno, Y. and Kubo, H. and Kushida, J. and Kuvezdie, D. and Lelas, D. and Lindfors, E. and Lombardi, S. and Longo, F. and Lopez, M. and Lopez-Oramas, A. and Majumdar, P. and Makariev, M. and Maneva, G. and Manganaro, M. and Mannheim, K. and Maraschi, L. and Mariotti, M. and Martinez, M. and Mazin, D. and Menzel, U. and Minev, M. and Mirzoyan, R. and Moralejo, A. and Moreno, V. and Moretti, E. and Munar-Adrover, P. and Neustroev, V. and Niedzwiecki, A. and Rosillo, M. Nievas and Nilsson, K. and Nishijima, K. and Noda, K. and Nogues, L. and Paiano, S. and Palacio, J. and Paneque, D. and Paoletti, R. and Paredes, J. M. and Paredes-Fortuny, X. and Pedaletti, G. and Peresano, M. and Perri, L. and Persic, M. and Moroni, P. G. Prada and Prandini, E. and Puljak, I. and Garcia, J. R. and Reichardt, I. and Rhode, W. and Riti, M. and Rico, J. and Saito, T. and Satalecka, K. and Schroeder, S. and Schweizer, T. and Shore, S. N. and Sillanpaa, A. and Sitarek, J. and Sobczynskall, D. and Stamerra, A. and Strzys, M. and Surie, T. and Takalo, L. and Tavecchio, F. and Temnikov, P. and Terzie, T. and Tescaro, D. and Teshima, M. and Torres, D. F. and Torres-Alla, N. and Treves, A. and Vanzo, G. and Acosta, M. Vazquez and Vovk, I. and Ward, J. E. and Will, M. and Wu, M. H. and Zarie, D. and Abdalla, Hassan E. and Abramowski, A. and Aharonian, Felix A. and Benkhali, F. Ait and Akhperjanian, A. G. and Andersson, T. and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arrieta, M. and Aubert, P. and Backes, M. and Balzer, A. and Barnard, M. and Becherini, Y. and Tjus, J. Becker and Berge, D. and Bernhard, S. and Bernlohr, K. and Blackwell, R. and Bottcher, M. and Boisson, C. and Bolmont, J. and Bordas, Pol and Bregeon, J. and Brun, F. and Brun, P. and Bryan, M. and Btichele, M. and Bulik, T. and Capasso, M. and Carr, J. and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chalme-Calvet, R. and Chaves, R. C. G. and Chen, A. and Chevalier, J. and Chretien, M. and Coffaro, M. and Colafrancesco, S. and Cologna, G. and Condon, B. and Conrad, J. and Cui, Y. and Davids, I. D. and Decock, J. and Degrange, B. and Dei, C. and Devin, J. and Dewilt, P. and Dirson, L. and Djannati-Atai, A. and Domainko, W. and Donath, A. and Dutson, K. and Dyks, J. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, S. and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Forster, A. and Funk, S. and Ftifiling, M. and Gabici, S. and Gajdus, M. and Gallant, Y. A. and Garrigoux, T. and Giavitto, G. and Giebels, B. and Glicenstein, J. F. and Gottschal, D. and Goya, A. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hawkes, J. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hervet, O. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holler, M. and Horns, D. and Ivascenko, A. and Iwasaki, H. and Jacholkowska, A. and Jamrozy, M. and Janiak, M. and Jankowsky, D. and Jankowsky, F. and Jingo, M. and Jogler, T. and Jouvin, L. and Jung-Richardt, I. and Kastendieck, M. A. and Katarzyfiski, K. and Katsuragawa, M. and Katz, U. and Kerszberg, D. and Khangulyan, D. and Khelifi, B. and Kieffer, M. and King, J. and Klepser, S. and Klochkov, D. and Kluiniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, M. and Krtiger, P. P. and Laffon, H. and Lamanna, G. and Lau, J. and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, T. and Lorentz, M. and Liu, R. and Lopez-Coto, R. and Lypova, I. and Marandon, V. and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, M. and Meintjes, P. J. and Meyer, M. and Mitche, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Mora, K. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and De Naurois, M. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ott, S. and Ohm, S. and Ostrowski, M. and Oya, I. and Padovani, M. and Panter, M. and Parsons, R. D. and Pekeur, N. W. and Pelletier, G. and Perennes, C. and Petrucci, P. -O. and Peyaud, B. and Pie, Q. and Pita, S. and Poon, H. and Prokhorov, D. and Prokoph, H. and Ptffilhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Reimer, A. and Reimer, O. and Renaud, M. and De Los Reyes, R. and Richter, S. and Rieger, F. and Romoli, C. and Rowell, G. and Rudak, B. and Rulten, C. B. and Safi-Harb, S. and Sahakian, V. and Saito, S. and Salek, D. and Sanchez, D. A. and Santangelo, A. and Sasaki, M. and Schlickeiser, R. and Schtissler, F. and Schulz, A. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Settimo, M. and Seyffert, A. S. and Shafi, N. and Shilon, I. and Simoni, R. and So, H. and Spanier, F. and Spengler, G. and Spies, F. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Stycz, K. and Sushch, I. and Takahashi, T. and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tibaldo, L. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and Van der Walt, D. J. and Van Eldik, C. and Van Rensburg, C. and Van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, J. and Voisin, F. and Vok, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, A. and Willmann, P. and Wornlein, A. and Wouters, D. and Yang, R. and Zabalza, V. and Zaborov, D. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Zefi, F. and Ziegler, A. and Zywuckan, N.}, title = {Constraints on particle acceleration in SS433/W50 from MAGIC and HESS observations}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {612}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboratio MAGIC Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201731169}, pages = {8}, year = {2018}, abstract = {Context. The large jet kinetic power and non-thermal processes occurring in the microquasar SS 433 make this source a good candidate for a very high-energy (VHE) gamma-ray emitter. Gamma-ray fluxes above the sensitivity limits of current Cherenkov telescopes have been predicted for both the central X-ray binary system and the interaction regions of SS 433 jets with the surrounding W50 nebula. Non-thermal emission at lower energies has been previously reported, indicating that efficient particle acceleration is taking place in the system. Aims. We explore the capability of SS 433 to emit VHE gamma rays during periods in which the expected flux attenuation due to periodic eclipses (P-orb similar to 13.1 days) and precession of the circumstellar disk (P-pre similar to 162 days) periodically covering the central binary system is expected to be at its minimum. The eastern and western SS 433/W50 interaction regions are also examined using the whole data set available. We aim to constrain some theoretical models previously developed for this system with our observations. Methods. We made use of dedicated observations from the Major Atmospheric Gamma Imaging Cherenkov telescopes (MAGIC) and High Energy Spectroscopic System (H.E.S.S.) of SS 433 taken from 2006 to 2011. These observation were combined for the first time and accounted for a total effective observation time of 16.5 h, which were scheduled considering the expected phases of minimum absorption of the putative VHE emission. Gamma-ray attenuation does not affect the jet/medium interaction regions. In this case, the analysis of a larger data set amounting to similar to 40-80 h, depending on the region, was employed. Results. No evidence of VHE gamma-ray emission either from the central binary system or from the eastern/western interaction regions was found. Upper limits were computed for the combined data set. Differential fluxes from the central system are found to be less than or similar to 10(-12)-10(-13) TeV-1 cm(-2) s(-1) in an energy interval ranging from similar to few x 100 GeV to similar to few TeV. Integral flux limits down to similar to 10(-12)-10(-13) ph cm(-2) s(-1) and similar to 10(-13)-10(-14) ph cm(-2) s(-1) are obtained at 300 and 800 GeV, respectively. Our results are used to place constraints on the particle acceleration fraction at the inner jet regions and on the physics of the jet/medium interactions. Conclusions. Our findings suggest that the fraction of the jet kinetic power that is transferred to relativistic protons must be relatively small in SS 433, q(p) <= 2.5 x 10(-5), to explain the lack of TeV and neutrino emission from the central system. At the SS 433/W50 interface, the presence of magnetic fields greater than or similar to 10 mu G is derived assuming a synchrotron origin for the observed X-ray emission. This also implies the presence of high-energy electrons with E-e up to 50 TeV, preventing an efficient production of gamma-ray fluxes in these interaction regions.}, language = {en} } @article{AhnenAnsoldiAntonellietal.2017, author = {Ahnen, M. L. and Ansoldi, S. and Antonelli, L. A. and Antoranz, P. and Babic, A. and Banerjee, B. and Bangale, P. and de Almeida, U. Barres and Barrio, J. A. and Gonzalez, J. Becerra and Bednarek, W. and Bernardini, E. and Berti, A. and Biasuzzi, B. and Biland, A. and Blanch, O. and Bonnefoy, S. and Bonnoli, G. and Borracci, F. and Bretz, T. and Buson, S. and Carosi, A. and Chatterjee, A. and Clavero, R. and Colin, P. and Colombo, E. and Contreras, J. L. and Cortina, J. and Covino, S. and Da Vela, P. and Dazzi, F. and De Angelis, A. and De Lotto, B. and Wilhelmi, E. de Ona and Di Pierro, F. and Doert, M. and Dominguez, A. and Prester, D. Dominis and Dorner, D. and Doro, M. and Einecke, S. and Glawion, D. Eisenacher and Elsaesser, D. and Engelkemeier, M. and Ramazani, V. Fallah and Fernandez-Barral, A. and Fidalgo, D. and Fonseca, M. V. and Font, L. and Frantzen, K. and Fruck, C. and Galindo, D. and Lopez, R. J. Garcia and Garczarczyk, M. and Terrats, D. Garrido and Gaug, M. and Giammaria, P. and Godinovic, N. and Gonzalez Munoz, A. and Gora, D. and Guberman, D. and Hadasch, D. and Hahn, A. and Hanabata, Y. and Hayashida, M. and Herrera, J. and Hose, J. and Hrupec, D. and Hughes, G. and Idec, W. and Kodani, K. and Konno, Y. and Kubo, H. and Kushida, J. and La Barbera, A. and Lelas, D. and Lindfors, E. and Lombardi, S. and Longo, F. and Lopez, M. and Lopez-Coto, R. and Majumdar, P. and Makariev, M. and Mallot, K. and Maneva, G. and Manganaro, M. and Mannheim, K. and Maraschi, L. and Marcote, B. and Mariotti, M. and Martinez, M. and Mazin, D. and Menzel, U. and Miranda, J. M. and Mirzoyan, R. and Moralejo, A. and Moretti, E. and Nakajima, D. and Neustroev, V. and Niedzwiecki, A. and Rosillo, M. Nievas and Nilsson, K. and Nishijima, K. and Noda, K. and Nogues, L. and Overkemping, A. and Paiano, S. and Palacio, J. and Palatiello, M. and Paneque, D. and Paoletti, R. and Paredes, J. M. and Paredes-Fortuny, X. and Pedaletti, G. and Peresano, M. and Perri, L. and Persic, M. and Poutanen, J. and Moroni, P. G. Prada and Prandini, E. and Puljak, I. and Reichardt, I. and Rhode, W. and Ribo, M. and Rico, J. and Rodriguez Garcia, J. and Saito, T. and Satalecka, K. and Schroder, S. and Schultz, C. and Schweizer, T. and Shore, S. N. and Sillanpaa, A. and Sitarek, J. and Snidaric, I. and Sobczynska, D. and Stamerra, A. and Steinbring, T. and Strzys, M. and Suric, T. and Takalo, L. and Tavecchio, F. and Temnikov, P. and Terzic, T. and Tescaro, D. and Teshima, M. and Thaele, J. and Torres, D. F. and Toyama, T. and Treves, A. and Vanzo, G. and Verguilov, V. and Vovk, I. and Ward, J. E. and Will, M. and Wu, M. H. and Zanin, R. and Abeysekara, A. U. and Archambault, S. and Archer, A. and Benbow, W. and Bird, R. and Buchovecky, M. and Buckley, J. H. and Bugaev, V. and Connolly, M. P. and Cui, W. and Dickinson, H. J. and Falcone, A. and Feng, Q. and Finley, J. P. and Fleischhack, H. and Flinders, A. and Fortson, L. and Gillanders, G. H. and Griffin, S. and Grube, J. and Huetten, M. and Hanna, D. and Holder, J. and Humensky, T. B. and Kaaret, P. and Kar, P. and Kelley-Hoskins, N. and Kertzman, M. and Kieda, D. and Krause, M. and Krennrich, F. and Lang, M. J. and Maier, G. and McCann, A. and Moriarty, P. and Mukherjee, R. and Nieto, D. and Ong, R. A. and Otte, N. and Park, N. and Perkins, J. and Pichel, A. and Pohl, M. and Popkow, A. and Pueschel, Elisa and Quinn, J. and Ragan, K. and Reynolds, P. T. and Richards, G. T. and Roache, E. and Rovero, A. C. and Rulten, C. and Sadeh, I. and Santander, M. and Sembroski, G. H. and Shahinyan, K. and Telezhinsky, Igor O. and Tucci, J. V. and Tyler, J. and Wakely, S. P. and Weinstein, A. and Wilcox, P. and Wilhelm, Alina and Williams, D. A. and Zitzer, B. and Razzaque, S. and Villata, M. and Raiteri, C. M. and Aller, H. D. and Aller, M. F. and Larionov, V. M. and Arkharov, A. A. and Blinov, D. A. and Efimova, N. V. and Grishina, T. S. and Hagen-Thorn, V. A. and Kopatskaya, E. N. and Larionova, L. V. and Larionova, E. G. and Morozova, D. A. and Troitsky, I. S. and Ligustri, R. and Calcidese, P. and Berdyugin, A. and Kurtanidze, O. M. and Nikolashvili, M. G. and Kimeridze, G. N. and Sigua, L. A. and Kurtanidze, S. O. and Chigladze, R. A. and Chen, W. P. and Koptelova, E. and Sakamoto, T. and Sadun, A. C. and Moody, J. W. and Pace, C. and Pearson, R. and Yatsu, Y. and Mori, Y. and Carraminyana, A. and Carrasco, L. and de la Fuente, E. and Norris, J. P. and Smith, P. S. and Wehrle, A. and Gurwell, M. A. and Zook, A. and Pagani, C. and Perri, M. and Capalbi, M. and Cesarini, A. and Krimm, H. A. and Kovalev, Y. Y. and Kovalev, Yu. A. and Ros, E. and Pushkarev, A. B. and Lister, M. L. and Sokolovsky, K. V. and Kadler, M. and Piner, G. and Lahteenmaki, A. and Tornikoski, M. and Angelakis, E. and Krichbaum, T. P. and Nestoras, I. and Fuhrmann, L. and Zensus, J. A. and Cassaro, P. and Orlati, A. and Maccaferri, G. and Leto, P. and Giroletti, M. and Richards, J. L. and Max-Moerbeck, W. and Readhead, A. C. S.}, title = {Multiband variability studies and novel broadband SED modeling of Mrk 501 in 2009}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {603}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {MAGIC Collaboration;VERITAS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201629540}, pages = {30}, year = {2017}, abstract = {Aims. We present an extensive study of the BL Lac object Mrk 501 based on a data set collected during the multi-instrument campaign spanning from 2009 March 15 to 2009 August 1, which includes, among other instruments, MAGIC, VERITAS, Whipple 10 m, and Fermi-LAT to cover the gamma-ray range from 0.1 GeV to 20 TeV; RXTE and Swift to cover wavelengths from UV to hard X-rays; and GASP-WEBT, which provides coverage of radio and optical wavelengths. Optical polarization measurements were provided for a fraction of the campaign by the Steward and St. Petersburg observatories. We evaluate the variability of the source and interband correlations, the gamma-ray flaring activity occurring in May 2009, and interpret the results within two synchrotron self-Compton (SSC) scenarios. Methods. The multiband variability observed during the full campaign is addressed in terms of the fractional variability, and the possible correlations are studied by calculating the discrete correlation function for each pair of energy bands where the significance was evaluated with dedicated Monte Carlo simulations. The space of SSC model parameters is probed following a dedicated grid-scan strategy, allowing for a wide range of models to be tested and offering a study of the degeneracy of model-to-data agreement in the individual model parameters, hence providing a less biased interpretation than the "single-curve SSC model adjustment" typically reported in the literature. Results. We find an increase in the fractional variability with energy, while no significant interband correlations of flux changes are found on the basis of the acquired data set. The SSC model grid-scan shows that the flaring activity around May 22 cannot be modeled adequately with a one-zone SSC scenario (using an electron energy distribution with two breaks), while it can be suitably described within a two (independent) zone SSC scenario. Here, one zone is responsible for the quiescent emission from the averaged 4.5-month observing period, while the other one, which is spatially separated from the first, dominates the flaring emission occurring at X-rays and very-high-energy (> 100 GeV, VHE) gamma-rays. The flaring activity from May 1, which coincides with a rotation of the electric vector polarization angle (EVPA), cannot be satisfactorily reproduced by either a one-zone or a two-independent-zone SSC model, yet this is partially affected by the lack of strictly simultaneous observations and the presence of large flux changes on sub-hour timescales (detected at VHE gamma rays). Conclusions. The higher variability in the VHE emission and lack of correlation with the X-ray emission indicate that, at least during the 4.5-month observing campaign in 2009, the highest energy (and most variable) electrons that are responsible for the VHE gamma rays do not make a dominant contribution to the similar to 1 keV emission. Alternatively, there could be a very variable component contributing to the VHE gamma-ray emission in addition to that coming from the SSC scenario. The studies with our dedicated SSC grid-scan show that there is some degeneracy in both the one-zone and the two-zone SSC scenarios probed, with several combinations of model parameters yielding a similar model-to-data agreement, and some parameters better constrained than others. The observed gamma-ray flaring activity, with the EVPA rotation coincident with the first gamma-ray flare, resembles those reported previously for low frequency peaked blazars, hence suggesting that there are many similarities in the flaring mechanisms of blazars with different jet properties.}, language = {en} } @article{ChipmanFerrierBrenaetal.2014, author = {Chipman, Ariel D. and Ferrier, David E. K. and Brena, Carlo and Qu, Jiaxin and Hughes, Daniel S. T. and Schroeder, Reinhard and Torres-Oliva, Montserrat and Znassi, Nadia and Jiang, Huaiyang and Almeida, Francisca C. and Alonso, Claudio R. and Apostolou, Zivkos and Aqrawi, Peshtewani and Arthur, Wallace and Barna, Jennifer C. J. and Blankenburg, Kerstin P. and Brites, Daniela and Capella-Gutierrez, Salvador and Coyle, Marcus and Dearden, Peter K. and Du Pasquier, Louis and Duncan, Elizabeth J. and Ebert, Dieter and Eibner, Cornelius and Erikson, Galina and Evans, Peter D. and Extavour, Cassandra G. and Francisco, Liezl and Gabaldon, Toni and Gillis, William J. and Goodwin-Horn, Elizabeth A. and Green, Jack E. and Griffiths-Jones, Sam and Grimmelikhuijzen, Cornelis J. P. and Gubbala, Sai and Guigo, Roderic and Han, Yi and Hauser, Frank and Havlak, Paul and Hayden, Luke and Helbing, Sophie and Holder, Michael and Hui, Jerome H. L. and Hunn, Julia P. and Hunnekuhl, Vera S. and Jackson, LaRonda and Javaid, Mehwish and Jhangiani, Shalini N. and Jiggins, Francis M. and Jones, Tamsin E. and Kaiser, Tobias S. and Kalra, Divya and Kenny, Nathan J. and Korchina, Viktoriya and Kovar, Christie L. and Kraus, F. Bernhard and Lapraz, Francois and Lee, Sandra L. and Lv, Jie and Mandapat, Christigale and Manning, Gerard and Mariotti, Marco and Mata, Robert and Mathew, Tittu and Neumann, Tobias and Newsham, Irene and Ngo, Dinh N. and Ninova, Maria and Okwuonu, Geoffrey and Ongeri, Fiona and Palmer, William J. and Patil, Shobha and Patraquim, Pedro and Pham, Christopher and Pu, Ling-Ling and Putman, Nicholas H. and Rabouille, Catherine and Ramos, Olivia Mendivil and Rhodes, Adelaide C. and Robertson, Helen E. and Robertson, Hugh M. and Ronshaugen, Matthew and Rozas, Julio and Saada, Nehad and Sanchez-Gracia, Alejandro and Scherer, Steven E. and Schurko, Andrew M. and Siggens, Kenneth W. and Simmons, DeNard and Stief, Anna and Stolle, Eckart and Telford, Maximilian J. and Tessmar-Raible, Kristin and Thornton, Rebecca and van der Zee, Maurijn and von Haeseler, Arndt and Williams, James M. and Willis, Judith H. and Wu, Yuanqing and Zou, Xiaoyan and Lawson, Daniel and Muzny, Donna M. and Worley, Kim C. and Gibbs, Richard A. and Akam, Michael and Richards, Stephen}, title = {The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima}, series = {PLoS biology}, volume = {12}, journal = {PLoS biology}, number = {11}, publisher = {PLoS}, address = {San Fransisco}, issn = {1545-7885}, doi = {10.1371/journal.pbio.1002005}, pages = {24}, year = {2014}, abstract = {Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.}, language = {en} } @article{HorikoshiYaghootkarMookKanamorietal.2013, author = {Horikoshi, Momoko and Yaghootkar, Hanieh and Mook-Kanamori, Dennis O. and Sovio, Ulla and Taal, H. Rob and Hennig, Branwen J. and Bradfield, Jonathan P. and St Pourcain, Beate and Evans, David M. and Charoen, Pimphen and Kaakinen, Marika and Cousminer, Diana L. and Lehtimaki, Terho and Kreiner-Moller, Eskil and Warrington, Nicole M. and Bustamante, Mariona and Feenstra, Bjarke and Berry, Diane J. and Thiering, Elisabeth and Pfab, Thiemo and Barton, Sheila J. and Shields, Beverley M. and Kerkhof, Marjan and van Leeuwen, Elisabeth M. and Fulford, Anthony J. and Kutalik, Zoltan and Zhao, Jing Hua and den Hoed, Marcel and Mahajan, Anubha and Lindi, Virpi and Goh, Liang-Kee and Hottenga, Jouke-Jan and Wu, Ying and Raitakari, Olli T. and Harder, Marie N. and Meirhaeghe, Aline and Ntalla, Ioanna and Salem, Rany M. and Jameson, Karen A. and Zhou, Kaixin and Monies, Dorota M. and Lagou, Vasiliki and Kirin, Mirna and Heikkinen, Jani and Adair, Linda S. and Alkuraya, Fowzan S. and Al-Odaib, Ali and Amouyel, Philippe and Andersson, Ehm Astrid and Bennett, Amanda J. and Blakemore, Alexandra I. F. and Buxton, Jessica L. and Dallongeville, Jean and Das, Shikta and de Geus, Eco J. C. and Estivill, Xavier and Flexeder, Claudia and Froguel, Philippe and Geller, Frank and Godfrey, Keith M. and Gottrand, Frederic and Groves, Christopher J. and Hansen, Torben and Hirschhorn, Joel N. and Hofman, Albert and Hollegaard, Mads V. and Hougaard, David M. and Hyppoenen, Elina and Inskip, Hazel M. and Isaacs, Aaron and Jorgensen, Torben and Kanaka-Gantenbein, Christina and Kemp, John P. and Kiess, Wieland and Kilpelainen, Tuomas O. and Klopp, Norman and Knight, Bridget A. and Kuzawa, Christopher W. and McMahon, George and Newnham, John P. and Niinikoski, Harri and Oostra, Ben A. and Pedersen, Louise and Postma, Dirkje S. and Ring, Susan M. and Rivadeneira, Fernando and Robertson, Neil R. and Sebert, Sylvain and Simell, Olli and Slowinski, Torsten and Tiesler, Carla M. T. and Toenjes, Anke and Vaag, Allan and Viikari, Jorma S. and Vink, Jacqueline M. and Vissing, Nadja Hawwa and Wareham, Nicholas J. and Willemsen, Gonneke and Witte, Daniel R. and Zhang, Haitao and Zhao, Jianhua and Wilson, James F. and Stumvoll, Michael and Prentice, Andrew M. and Meyer, Brian F. and Pearson, Ewan R. and Boreham, Colin A. G. and Cooper, Cyrus and Gillman, Matthew W. and Dedoussis, George V. and Moreno, Luis A. and Pedersen, Oluf and Saarinen, Maiju and Mohlke, Karen L. and Boomsma, Dorret I. and Saw, Seang-Mei and Lakka, Timo A. and Koerner, Antje and Loos, Ruth J. F. and Ong, Ken K. and Vollenweider, Peter and van Duijn, Cornelia M. and Koppelman, Gerard H. and Hattersley, Andrew T. and Holloway, John W. and Hocher, Berthold and Heinrich, Joachim and Power, Chris and Melbye, Mads and Guxens, Monica and Pennell, Craig E. and Bonnelykke, Klaus and Bisgaard, Hans and Eriksson, Johan G. and Widen, Elisabeth and Hakonarson, Hakon and Uitterlinden, Andre G. and Pouta, Anneli and Lawlor, Debbie A. and Smith, George Davey and Frayling, Timothy M. and McCarthy, Mark I. and Grant, Struan F. A. and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and Timpson, Nicholas J. and Prokopenko, Inga and Freathy, Rachel M.}, title = {New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism}, series = {Nature genetics}, volume = {45}, journal = {Nature genetics}, number = {1}, publisher = {Nature Publ. Group}, address = {New York}, organization = {MAGIC, Early Growth Genetics EGG}, issn = {1061-4036}, doi = {10.1038/ng.2477}, pages = {76 -- U115}, year = {2013}, abstract = {Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.}, language = {en} } @article{DeAngelisTatischeffTavanietal.2017, author = {De Angelis, A. and Tatischeff, V. and Tavani, M. and Oberlack, U. and Grenier, I. and Hanloni, L. and Walter, R. and Argan, A. and Von Ballmoos, P. and Bulgarelli, A. and Donnarumma, I. and Hernanz, M. and Kuvvetli, I. and Pearce, M. and Zdziarski, A. and Aboudan, A. and Ajello, M. and Ambrosi, G. and Bernard, D. and Bernardini, E. and Bonvicini, V. and Brogna, A. and Branchesi, M. and Budtz-Jorgensen, C. and Bykov, A. M. and Campana, R. and Cardillo, M. and Coppi, P. and De Martino, D. and Diehl, R. and Doro, M. and Fioretti, V. and Funk, S. and Ghisellini, G. and Grove, E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Isern, J. and Kanbach, G. and Kiener, J. and Knodlseder, J. and Labanti, C. and Laurent, P. and Limousin, O. and Longo, F. and Mannheim, K. and Marisaldi, M. and Martinez, M. and Mazziotta, Mario Nicola and McEnery, J. and Mereghetti, S. and Minervini, G. and Moiseev, A. and Morselli, A. and Nakazawa, K. and Orleanski, P. and Paredes, J. M. and Patricelli, B. and Pevre, J. and Piano, G. and Pohl, Martin and Ramarijaona, H. and Rando, R. and Reichardt, I. and Roncadelli, M. and Silva, R. and Tavecchio, F. and Thompson, D. J. and Turolla, R. and Ulyanov, A. and Vacchi, A. and Wu, X. and Zoglauer, A.}, title = {The e-ASTROGAM mission Exploring the extreme Universe with gamma rays in the MeV - GeV range}, series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, volume = {44}, journal = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, publisher = {Springer}, address = {Dordrecht}, organization = {The e-ASTROGAM Collaboration}, issn = {0922-6435}, doi = {10.1007/s10686-017-9533-6}, pages = {25 -- 82}, year = {2017}, abstract = {e-ASTROGAM ('enhanced ASTROGAM') is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV - the lower energy limit can be pushed to energies as low as 150 keV, albeit with rapidly degrading angular resolution, for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and the promise of eLISA.}, language = {en} } @article{DeAngelisTatischeffGrenieretal.2018, author = {De Angelis, A. and Tatischeff, V. and Grenier, I. A. and McEnery, J. and Mallamaci, Manuela and Tavani, M. and Oberlack, U. and Hanlon, L. and Walter, R. and Argan, A. and Von Ballmoos, P. and Bulgarelli, A. and Bykov, A. and Hernanz, M. and Kanbach, G. and Kuvvetli, I. and Pearce, M. and Zdziarski, A. and Conrad, J. and Ghisellini, G. and Harding, A. and Isern, J. and Leising, M. and Longo, F. and Madejski, G. and Martinez, M. and Mazziotta, Mario Nicola and Paredes, J. M. and Pohl, Martin and Rando, R. and Razzano, M. and Aboudan, A. and Ackermann, M. and Addazi, A. and Ajello, M. and Albertus, C. and Alvarez, J. M. and Ambrosi, G. and Anton, S. and Antonelli, L. A. and Babic, A. and Baibussinov, B. and Balbom, M. and Baldini, L. and Balman, S. and Bambi, C. and Barres de Almeida, U. and Barrio, J. A. and Bartels, R. and Bastieri, D. and Bednarek, W. and Bernard, D. and Bernardini, E. and Bernasconi, T. and Bertucci, B. and Biland, A. and Bissaldi, E. and Boettcher, M. and Bonvicini, V. and Bosch-Ramon, V. and Bottacini, E. and Bozhilov, V. and Bretz, T. and Branchesi, M. and Brdar, V. and Bringmann, T. and Brogna, A. and Jorgensen, C. Budtz and Busetto, G. and Buson, S. and Busso, M. and Caccianiga, A. and Camera, S. and Campana, R. and Caraveo, P. and Cardillo, M. and Carlson, P. and Celestin, S. and Cermeno, M. and Chen, A. and Cheung, C. C. and Churazov, E. and Ciprini, S. and Coc, A. and Colafrancesco, S. and Coleiro, A. and Collmar, W. and Coppi, P. and Curado da Silva, R. and Cutini, S. and De Lotto, B. and de Martino, D. and De Rosa, A. and Del Santo, M. and Delgado, L. and Diehl, R. and Dietrich, S. and Dolgov, A. D. and Dominguez, A. and Prester, D. Dominis and Donnarumma, I. and Dorner, D. and Doro, M. and Dutra, M. and Elsaesser, D. and Fabrizio, M. and Fernandez-Barral, A. and Fioretti, V. and Foffano, L. and Formato, V. and Fornengo, N. and Foschini, L. and Franceschini, A. and Franckowiak, A. and Funk, S. and Fuschino, F. and Gaggero, D. and Galanti, G. and Gargano, F. and Gasparrini, D. and Gehrz, R. and Giammaria, P. and Giglietto, N. and Giommi, P. and Giordano, F. and Giroletti, M. and Ghirlanda, G. and Godinovic, N. and Gouiffes, C. and Grove, J. E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Hryczuk, A. and Jean, P. and Johnson, T. and Jose, J. and Kaufmann, S. and Khelifi, B. and Kiener, J. and Knodlseder, J. and Kolem, M. and Kopp, J. and Kozhuharov, V. and Labanti, C. and Lalkovski, S. and Laurent, P. and Limousin, O. and Linares, M. and Lindfors, E. and Lindner, M. and Liu, J. and Lombardi, S. and Loparco, F. and Lopez-Coto, R. and Lopez Moya, M. and Lott, B. and Lubrano, P. and Malyshev, D. and Mankuzhiyil, N. and Mannheim, K. and Marcha, M. J. and Marciano, A. and Marcote, B. and Mariotti, M. and Marisaldi, M. and McBreen, S. and Mereghetti, S. and Merle, A. and Mignani, R. and Minervini, G. and Moiseev, A. and Morselli, A. and Moura, F. and Nakazawa, K. and Nava, L. and Nieto, D. and Orienti, M. and Orio, M. and Orlando, E. and Orleanski, P. and Paiano, S. and Paoletti, R. and Papitto, A. and Pasquato, M. and Patricelli, B. and Perez-Garcia, M. A. and Persic, M. and Piano, G. and Pichel, A. and Pimenta, M. and Pittori, C. and Porter, T. and Poutanen, J. and Prandini, E. and Prantzos, N. and Produit, N. and Profumo, S. and Queiroz, F. S. and Raino, S. and Raklev, A. and Regis, M. and Reichardt, I. and Rephaeli, Y. and Rico, J. and Rodejohann, W. and Fernandez, G. Rodriguez and Roncadelli, M. and Roso, L. and Rovero, A. and Ruffini, R. and Sala, G. and Sanchez-Conde, M. A. and Santangelo, A. and Parkinson, P. Saz and Sbarrato, T. and Shearer, A. and Shellard, R. and Short, K. and Siegert, T. and Siqueira, C. and Spinelli, P. and Stamerra, A. and Starrfield, S. and Strong, A. and Strumke, I. and Tavecchio, F. and Taverna, R. and Terzic, T. and Thompson, D. J. and Tibolla, O. and Torres, D. F. and Turolla, R. and Ulyanov, A. and Ursi, A. and Vacchi, A. and Van den Abeele, J. and Vankova-Kirilovai, G. and Venter, C. and Verrecchia, F. and Vincent, P. and Wang, X. and Weniger, C. and Wu, X. and Zaharijas, G. and Zampieri, L. and Zane, S. and Zimmer, S. and Zoglauer, A.}, title = {Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics}, series = {Journal of High Energy Astrophysics}, volume = {19}, journal = {Journal of High Energy Astrophysics}, publisher = {Elsevier}, address = {Amsterdam}, organization = {e-ASTROGAM Collaboration}, issn = {2214-4048}, doi = {10.1016/j.jheap.2018.07.001}, pages = {1 -- 106}, year = {2018}, language = {en} } @article{WarringtonBeaumontHorikoshietal.2019, author = {Warrington, Nicole and Beaumont, Robin and Horikoshi, Momoko and Day, Felix R. and Helgeland, {\O}yvind and Laurin, Charles and Bacelis, Jonas and Peng, Shouneng and Hao, Ke and Feenstra, Bjarke and Wood, Andrew R. and Mahajan, Anubha and Tyrrell, Jessica and Robertson, Neil R. and Rayner, N. William and Qiao, Zhen and Moen, Gunn-Helen and Vaudel, Marc and Marsit, Carmen and Chen, Jia and Nodzenski, Michael and Schnurr, Theresia M. and Zafarmand, Mohammad Hadi and Bradfield, Jonathan P. and Grarup, Niels and Kooijman, Marjolein N. and Li-Gao, Ruifang and Geller, Frank and Ahluwalia, Tarunveer Singh and Paternoster, Lavinia and Rueedi, Rico and Huikari, Ville and Hottenga, Jouke-Jan and Lyytik{\"a}inen, Leo-Pekka and Cavadino, Alana and Metrustry, Sarah and Cousminer, Diana L. and Wu, Ying and Thiering, Elisabeth Paula and Wang, Carol A. and Have, Christian Theil and Vilor-Tejedor, Natalia and Joshi, Peter K. and Painter, Jodie N. and Ntalla, Ioanna and Myhre, Ronny and Pitk{\"a}nen, Niina and van Leeuwen, Elisabeth M. and Joro, Raimo and Lagou, Vasiliki and Richmond, Rebecca C. and Espinosa, Ana and Barton, Sheila J. and Inskip, Hazel M. and Holloway, John W. and Santa-Marina, Loreto and Estivill, Xavier and Ang, Wei and Marsh, Julie A. and Reichetzeder, Christoph and Marullo, Letizia and Hocher, Berthold and Lunetta, Kathryn L. and Murabito, Joanne M. and Relton, Caroline L. and Kogevinas, Manolis and Chatzi, Leda and Allard, Catherine and Bouchard, Luigi and Hivert, Marie-France and Zhang, Ge and Muglia, Louis J. and Heikkinen, Jani and Morgen, Camilla S. and van Kampen, Antoine H. C. and van Schaik, Barbera D. C. and Mentch, Frank D. and Langenberg, Claudia and Scott, Robert A. and Zhao, Jing Hua and Hemani, Gibran and Ring, Susan M. and Bennett, Amanda J. and Gaulton, Kyle J. and Fernandez-Tajes, Juan and van Zuydam, Natalie R. and Medina-Gomez, Carolina and de Haan, Hugoline G. and Rosendaal, Frits R. and Kutalik, Zolt{\´a}n and Marques-Vidal, Pedro and Das, Shikta and Willemsen, Gonneke and Mbarek, Hamdi and M{\"u}ller-Nurasyid, Martina and Standl, Marie and Appel, Emil V. R. and Fonvig, Cilius Esmann and Trier, Caecilie and van Beijsterveldt, Catharina E. M. and Murcia, Mario and Bustamante, Mariona and Bon{\`a}s-Guarch, S{\´i}lvia and Hougaard, David M. and Mercader, Josep M. and Linneberg, Allan and Schraut, Katharina E. and Lind, Penelope A. and Medland, Sarah Elizabeth and Shields, Beverley M. and Knight, Bridget A. and Chai, Jin-Fang and Panoutsopoulou, Kalliope and Bartels, Meike and S{\´a}nchez, Friman and Stokholm, Jakob and Torrents, David and Vinding, Rebecca K. and Willems, Sara M. and Atalay, Mustafa and Chawes, Bo L. and Kovacs, Peter and Prokopenko, Inga and Tuke, Marcus A. and Yaghootkar, Hanieh and Ruth, Katherine S. and Jones, Samuel E. and Loh, Po-Ru and Murray, Anna and Weedon, Michael N. and T{\"o}njes, Anke and Stumvoll, Michael and Michaelsen, Kim Fleischer and Eloranta, Aino-Maija and Lakka, Timo A. and van Duijn, Cornelia M. and Kiess, Wieland and Koerner, Antje and Niinikoski, Harri and Pahkala, Katja and Raitakari, Olli T. and Jacobsson, Bo and Zeggini, Eleftheria and Dedoussis, George V. and Teo, Yik-Ying and Saw, Seang-Mei and Montgomery, Grant W. and Campbell, Harry and Wilson, James F. and Vrijkotte, Tanja G. M. and Vrijheid, Martine and de Geus, Eco J. C. N. and Hayes, M. Geoffrey and Kadarmideen, Haja N. and Holm, Jens-Christian and Beilin, Lawrence J. and Pennell, Craig E. and Heinrich, Joachim and Adair, Linda S. and Borja, Judith B. and Mohlke, Karen L. and Eriksson, Johan G. and Widen, Elisabeth E. and Hattersley, Andrew T. and Spector, Tim D. and Kaehoenen, Mika and Viikari, Jorma S. and Lehtimaeki, Terho and Boomsma, Dorret I. and Sebert, Sylvain and Vollenweider, Peter and Sorensen, Thorkild I. A. and Bisgaard, Hans and Bonnelykke, Klaus and Murray, Jeffrey C. and Melbye, Mads and Nohr, Ellen A. and Mook-Kanamori, Dennis O. and Rivadeneira, Fernando and Hofman, Albert and Felix, Janine F. and Jaddoe, Vincent W. V. and Hansen, Torben and Pisinger, Charlotta and Vaag, Allan A. and Pedersen, Oluf and Uitterlinden, Andre G. and Jarvelin, Marjo-Riitta and Power, Christine and Hypponen, Elina and Scholtens, Denise M. and Lowe, William L. and Smith, George Davey and Timpson, Nicholas J. and Morris, Andrew P. and Wareham, Nicholas J. and Hakonarson, Hakon and Grant, Struan F. A. and Frayling, Timothy M. and Lawlor, Debbie A. and Njolstad, Pal R. and Johansson, Stefan and Ong, Ken K. and McCarthy, Mark I. and Perry, John R. B. and Evans, David M. and Freathy, Rachel M.}, title = {Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {5}, publisher = {Nature Publ. Group}, address = {New York}, organization = {EGG Consortium}, issn = {1061-4036}, pages = {804 -- +}, year = {2019}, abstract = {Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.}, language = {en} } @inproceedings{TatischeffDeAngelisTavanietal.2018, author = {Tatischeff, V. and De Angelis, A. and Tavani, M. and Grenier, I. and Oberlack, U. and Hanlon, L. and Walter, R. and Argan, A. and von Ballmoos, P. and Bulgarelli, A. and Donnarumma, I. and Hernanz, Margarita and Kuvvetli, I. and Mallamaci, M. and Pearce, M. and Zdziarski, A. and Aboudan, A. and Ajello, M. and Ambrosi, G. and Bernard, D. and Bernardini, E. and Bonvicini, V. and Brogna, A. and Branchesi, M. and Budtz-Jorgensen, C. and Bykov, A. and Campana, R. and Cardillo, M. and Ciprini, S. and Coppi, P. and Cumani, P. and da Silva, R. M. Curado and De Martino, D. and Diehl, R. and Doro, M. and Fioretti, V. and Funk, S. and Ghisellini, G. and Giordano, F. and Grove, J. E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Isern, J. and Kanbach, G. and Kiener, J. and Knodlseder, J. and Labanti, C. and Laurent, P. and Leising, M. and Limousin, O. and Longo, F. and Mannheim, K. and Marisaldi, M. and Martinez, M. and Mazziotta, M. N. and McEnery, J. E. and Mereghetti, S. and Minervini, G. and Moiseev, A. and Morselli, A. and Nakazawa, K. and Orleanski, P. and Paredes, J. M. and Patricelli, B. and Peyre, J. and Piano, G. and Pohl, Martin and Rando, R. and Roncadelli, M. and Tavecchio, F. and Thompson, D. J. and Turolla, R. and Ulyanov, A. and Vacchi, A. and Wu, X. and Zoglauer, A.}, title = {The e-ASTROGAM gamma-ray space observatory for the multimessenger astronomy of the 2030s}, series = {Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray}, volume = {10699}, booktitle = {Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray}, editor = {DenHerder, JWA Nikzad}, publisher = {SPIE - The International Society for Optical Engineering}, address = {Bellingham}, isbn = {978-1-5106-1952-4}, issn = {0277-786X}, doi = {10.1117/12.2315151}, pages = {15}, year = {2018}, abstract = {e-ASTROGAM is a concept for a breakthrough observatory space mission carrying a gamma-ray telescope dedicated to the study of the non-thermal Universe in the photon energy range from 0.15 MeV to 3 GeV. The lower energy limit can be pushed down to energies as low as 30 keV for gamma-ray burst detection with the calorimeter. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with remarkable polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous and current generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will be a major player of the multiwavelength, multimessenger time-domain astronomy of the 2030s, and provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LISA, LIGO, Virgo, KAGRA, the Einstein Telescope and the Cosmic Explorer, IceCube-Gen2 and KM3NeT, SKA, ALMA, JWST, E-ELT, LSST, Athena, and the Cherenkov Telescope Array.}, language = {en} } @article{AartsAndersonAndersonetal.2015, author = {Aarts, Alexander A. and Anderson, Joanna E. and Anderson, Christopher J. and Attridge, Peter R. and Attwood, Angela and Axt, Jordan and Babel, Molly and Bahnik, Stepan and Baranski, Erica and Barnett-Cowan, Michael and Bartmess, Elizabeth and Beer, Jennifer and Bell, Raoul and Bentley, Heather and Beyan, Leah and Binion, Grace and Borsboom, Denny and Bosch, Annick and Bosco, Frank A. and Bowman, Sara D. and Brandt, Mark J. and Braswell, Erin and Brohmer, Hilmar and Brown, Benjamin T. and Brown, Kristina and Bruening, Jovita and Calhoun-Sauls, Ann and Callahan, Shannon P. and Chagnon, Elizabeth and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cillessen, Linda and Clay, Russ and Cleary, Hayley and Cloud, Mark D. and Cohn, Michael and Cohoon, Johanna and Columbus, Simon and Cordes, Andreas and Costantini, Giulio and Alvarez, Leslie D. Cramblet and Cremata, Ed and Crusius, Jan and DeCoster, Jamie and DeGaetano, Michelle A. and Della Penna, Nicolas and den Bezemer, Bobby and Deserno, Marie K. and Devitt, Olivia and Dewitte, Laura and Dobolyi, David G. and Dodson, Geneva T. and Donnellan, M. Brent and Donohue, Ryan and Dore, Rebecca A. and Dorrough, Angela and Dreber, Anna and Dugas, Michelle and Dunn, Elizabeth W. and Easey, Kayleigh and Eboigbe, Sylvia and Eggleston, Casey and Embley, Jo and Epskamp, Sacha and Errington, Timothy M. and Estel, Vivien and Farach, Frank J. and Feather, Jenelle and Fedor, Anna and Fernandez-Castilla, Belen and Fiedler, Susann and Field, James G. and Fitneva, Stanka A. and Flagan, Taru and Forest, Amanda L. and Forsell, Eskil and Foster, Joshua D. and Frank, Michael C. and Frazier, Rebecca S. and Fuchs, Heather and Gable, Philip and Galak, Jeff and Galliani, Elisa Maria and Gampa, Anup and Garcia, Sara and Gazarian, Douglas and Gilbert, Elizabeth and Giner-Sorolla, Roger and Gl{\"o}ckner, Andreas and G{\"o}llner, Lars and Goh, Jin X. and Goldberg, Rebecca and Goodbourn, Patrick T. and Gordon-McKeon, Shauna and Gorges, Bryan and Gorges, Jessie and Goss, Justin and Graham, Jesse and Grange, James A. and Gray, Jeremy and Hartgerink, Chris and Hartshorne, Joshua and Hasselman, Fred and Hayes, Timothy and Heikensten, Emma and Henninger, Felix and Hodsoll, John and Holubar, Taylor and Hoogendoorn, Gea and Humphries, Denise J. and Hung, Cathy O. -Y. and Immelman, Nathali and Irsik, Vanessa C. and Jahn, Georg and Jaekel, Frank and Jekel, Marc and Johannesson, Magnus and Johnson, Larissa G. and Johnson, David J. and Johnson, Kate M. and Johnston, William J. and Jonas, Kai and Joy-Gaba, Jennifer A. and Kappes, Heather Barry and Kelso, Kim and Kidwell, Mallory C. and Kim, Seung Kyung and Kirkhart, Matthew and Kleinberg, Bennett and Knezevic, Goran and Kolorz, Franziska Maria and Kossakowski, Jolanda J. and Krause, Robert Wilhelm and Krijnen, Job and Kuhlmann, Tim and Kunkels, Yoram K. and Kyc, Megan M. and Lai, Calvin K. and Laique, Aamir and Lakens, Daniel and Lane, Kristin A. and Lassetter, Bethany and Lazarevic, Ljiljana B. and LeBel, Etienne P. and Lee, Key Jung and Lee, Minha and Lemm, Kristi and Levitan, Carmel A. and Lewis, Melissa and Lin, Lin and Lin, Stephanie and Lippold, Matthias and Loureiro, Darren and Luteijn, Ilse and Mackinnon, Sean and Mainard, Heather N. and Marigold, Denise C. and Martin, Daniel P. and Martinez, Tylar and Masicampo, E. J. and Matacotta, Josh and Mathur, Maya and May, Michael and Mechin, Nicole and Mehta, Pranjal and Meixner, Johannes and Melinger, Alissa and Miller, Jeremy K. and Miller, Mallorie and Moore, Katherine and M{\"o}schl, Marcus and Motyl, Matt and M{\"u}ller, Stephanie M. and Munafo, Marcus and Neijenhuijs, Koen I. and Nervi, Taylor and Nicolas, Gandalf and Nilsonne, Gustav and Nosek, Brian A. and Nuijten, Michele B. and Olsson, Catherine and Osborne, Colleen and Ostkamp, Lutz and Pavel, Misha and Penton-Voak, Ian S. and Perna, Olivia and Pernet, Cyril and Perugini, Marco and Pipitone, R. Nathan and Pitts, Michael and Plessow, Franziska and Prenoveau, Jason M. and Rahal, Rima-Maria and Ratliff, Kate A. and Reinhard, David and Renkewitz, Frank and Ricker, Ashley A. and Rigney, Anastasia and Rivers, Andrew M. and Roebke, Mark and Rutchick, Abraham M. and Ryan, Robert S. and Sahin, Onur and Saide, Anondah and Sandstrom, Gillian M. and Santos, David and Saxe, Rebecca and Schlegelmilch, Rene and Schmidt, Kathleen and Scholz, Sabine and Seibel, Larissa and Selterman, Dylan Faulkner and Shaki, Samuel and Simpson, William B. and Sinclair, H. Colleen and Skorinko, Jeanine L. M. and Slowik, Agnieszka and Snyder, Joel S. and Soderberg, Courtney and Sonnleitner, Carina and Spencer, Nick and Spies, Jeffrey R. and Steegen, Sara and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and Talhelm, Thomas and Tapia, Megan and te Dorsthorst, Anniek and Thomae, Manuela and Thomas, Sarah L. and Tio, Pia and Traets, Frits and Tsang, Steve and Tuerlinckx, Francis and Turchan, Paul and Valasek, Milan and Van Aert, Robbie and van Assen, Marcel and van Bork, Riet and van de Ven, Mathijs and van den Bergh, Don and van der Hulst, Marije and van Dooren, Roel and van Doorn, Johnny and van Renswoude, Daan R. and van Rijn, Hedderik and Vanpaemel, Wolf and Echeverria, Alejandro Vasquez and Vazquez, Melissa and Velez, Natalia and Vermue, Marieke and Verschoor, Mark and Vianello, Michelangelo and Voracek, Martin and Vuu, Gina and Wagenmakers, Eric-Jan and Weerdmeester, Joanneke and Welsh, Ashlee and Westgate, Erin C. and Wissink, Joeri and Wood, Michael and Woods, Andy and Wright, Emily and Wu, Sining and Zeelenberg, Marcel and Zuni, Kellylynn}, title = {Estimating the reproducibility of psychological science}, series = {Science}, volume = {349}, journal = {Science}, number = {6251}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, organization = {Open Sci Collaboration}, issn = {1095-9203}, doi = {10.1126/science.aac4716}, pages = {8}, year = {2015}, abstract = {Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47\% of original effect sizes were in the 95\% confidence interval of the replication effect size; 39\% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68\% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.}, language = {en} } @article{MetzgerTachibanaWuetal.1997, author = {Metzger, R. M. and Tachibana, H. and Wu, X. and H{\"o}pfner, Ulf and Chen, Bin and Lakshmikantham, M. V. and Cava, Michael P.}, title = {Is Ashwell`s zwitterion a molecular diode?}, year = {1997}, language = {en} } @article{ZhaoXiaWuetal.2018, author = {Zhao, Liming and Xia, Yan and Wu, Xiao-Yuan and Schippers, Jos H. M. and Jing, Hai-Chun}, title = {Phenotypic analysis and molecular markers of leaf senescence}, series = {Plant Senescence: Methods and Protocols}, volume = {1744}, journal = {Plant Senescence: Methods and Protocols}, publisher = {Humana Press Inc.}, address = {Totowa}, isbn = {978-1-4939-7672-0}, issn = {1064-3745}, doi = {10.1007/978-1-4939-7672-0_3}, pages = {35 -- 48}, year = {2018}, abstract = {The process of leaf senescence consists of the final stage of leaf development. It has evolved as a mechanism to degrade macromolecules and micronutrients and remobilize them to other developing parts of the plant; hence it plays a central role for the survival of plants and crop production. During senescence, a range of physiological, morphological, cellular, and molecular events occur, which are generally referred to as the senescence syndrome that includes several hallmarks such as visible yellowing, loss of chlorophyll and water content, increase of ion leakage and cell death, deformation of chloroplast and cell structure, as well as the upregulation of thousands of so-called senescence-associated genes (SAGs) and downregulation of photosynthesis-associated genes (PAGs). This chapter is devoted to methods characterizing the onset and progression of leaf senescence at the morphological, physiological, cellular, and molecular levels. Leaf senescence normally progresses in an age-dependent manner but is also induced prematurely by a variety of environmental stresses in plants. Focused on the hallmarks of the senescence syndrome, a series of protocols is described to asses quantitatively the senescence process caused by developmental cues or environmental perturbations. We first briefly describe the senescence process, the events associated with the senescence syndrome, and the theories and methods to phenotype senescence. Detailed protocols for monitoring senescence in planta and in vitro, using the whole plant and the detached leaf, respectively, are presented. For convenience, most of the protocols use the model plant species Arabidopsis and rice, but they can be easily extended to other plants.}, language = {en} }