@misc{HeWuertzKozakKuehletal.2021,
  author    = {He, Yangyang and Wuertz-Kozak, Karin and Kuehl, Linn K. and Wippert, Pia-Maria},
  title     = {Extracellular vesicles: potential mediators of psychosocial stress contribution to osteoporosis?},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {11},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-52300},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-523007},
  pages     = {17},
  year      = {2021},
  abstract  = {Osteoporosis is characterized by low bone mass and damage to the bone tissue's microarchitecture, leading to increased fracture risk. Several studies have provided evidence for associations between psychosocial stress and osteoporosis through various pathways, including the hypothalamic-pituitary-adrenocortical axis, the sympathetic nervous system, and other endocrine factors. As psychosocial stress provokes oxidative cellular stress with consequences for mitochondrial function and cell signaling (e.g., gene expression, inflammation), it is of interest whether extracellular vesicles (EVs) may be a relevant biomarker in this context or act by transporting substances. EVs are intercellular communicators, transfer substances encapsulated in them, modify the phenotype and function of target cells, mediate cell-cell communication, and, therefore, have critical applications in disease progression and clinical diagnosis and therapy. This review summarizes the characteristics of EVs, their role in stress and osteoporosis, and their benefit as biological markers. We demonstrate that EVs are potential mediators of psychosocial stress and osteoporosis and may be beneficial in innovative research settings.},
  language  = {en}
}
@article{SchultebraucksDeuterDuesenbergetal.2016,
  author    = {Schultebraucks, Katharina and Deuter, Christian E. and Duesenberg, Moritz and Schulze, Lars and Hellmann-Regen, Julian and Domke, Antonia and Lockenvitz, Lisa and Kuehl, Linn K. and Otte, Christian and Wingenfeld, Katja},
  title     = {Selective attention to emotional cues and emotion recognition in healthy subjects: the role of mineralocorticoid receptor stimulation},
  series = {Psychopharmacology},
  volume    = {233},
  journal   = {Psychopharmacology},
  publisher = {Springer},
  address   = {New York},
  issn      = {0033-3158},
  doi       = {10.1007/s00213-016-4380-0},
  pages     = {3405 -- 3415},
  year      = {2016},
  abstract  = {Selective attention toward emotional cues and emotion recognition of facial expressions are important aspects of social cognition. Stress modulates social cognition through cortisol, which acts on glucocorticoid (GR) and mineralocorticoid receptors (MR) in the brain. We examined the role of MR activation on attentional bias toward emotional cues and on emotion recognition. We included 40 healthy young women and 40 healthy young men (mean age 23.9 +/- 3.3), who either received 0.4 mg of the MR agonist fludrocortisone or placebo. A dot-probe paradigm was used to test for attentional biases toward emotional cues (happy and sad faces). Moreover, we used a facial emotion recognition task to investigate the ability to recognize emotional valence (anger and sadness) from facial expression in four graded categories of emotional intensity (20, 30, 40, and 80 \%). In the emotional dot-probe task, we found a main effect of treatment and a treatment x valence interaction. Post hoc analyses revealed an attentional bias away from sad faces after placebo intake and a shift in selective attention toward sad faces compared to placebo. We found no attentional bias toward happy faces after fludrocortisone or placebo intake. In the facial emotion recognition task, there was no main effect of treatment. MR stimulation seems to be important in modulating quick, automatic emotional processing, i.e., a shift in selective attention toward negative emotional cues. Our results confirm and extend previous findings of MR function. However, we did not find an effect of MR stimulation on emotion recognition.},
  language  = {en}
}