@article{DuyduBasaranAydinetal.2018, author = {Duydu, Yalcin and Basaran, Nursen and Aydin, Sevtap and Ustundag, Aylin and Yalcin, Can {\"O}zg{\"u}r and Anlar, Hatice Gul and Bacanli, Merve and Aydos, Kaan and Atabekoglu, Cem Somer and Golka, Klaus and Ickstadt, Katja and Schwerdtle, Tanja and Werner, Matthias and Meyer, S{\"o}ren and Bolt, Hermann M.}, title = {Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions}, series = {Archives of toxicology : official journal of EUROTOX}, volume = {92}, journal = {Archives of toxicology : official journal of EUROTOX}, number = {10}, publisher = {Springer}, address = {Heidelberg}, issn = {0340-5761}, doi = {10.1007/s00204-018-2296-7}, pages = {3051 -- 3059}, year = {2018}, abstract = {Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 +/- 17.47 (7.95-106.8) mg B/day and 570.6 +/- 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds.}, language = {en} } @article{Goetz2011, author = {Goetz, Klaus Hermann}, title = {The development and current features of the German civil service system}, isbn = {978-1-84844243-6}, year = {2011}, language = {en} } @article{DuyduBasaranUstundagetal.2018, author = {Duydu, Yalcin and Basaran, Nursen and Ustundag, Aylin and Aydin, Sevtap and Yalcin, Can Ozgur and Anlar, Hatice Gul and Bacanli, Merve and Aydos, Kaan and Atabekoglu, Cem Somer and Golka, Klaus and Ickstadt, Katja and Schwerdtle, Tanja and Werner, Matthias and Meyer, S{\"o}ren and Bolt, Hermann M.}, title = {Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey}, series = {Archives of toxicology : official journal of EUROTOX}, volume = {92}, journal = {Archives of toxicology : official journal of EUROTOX}, number = {8}, publisher = {Springer}, address = {Heidelberg}, issn = {0340-5761}, doi = {10.1007/s00204-018-2238-4}, pages = {2475 -- 2485}, year = {2018}, abstract = {Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By contrast, studies on boron-mediated developmental effects in females are scarce. The present study was designed to fill this gap. Hundred and ninety nine females residing in Bandirma and Bigadic participated in this study investigating pregnancy outcomes. The participants constituted a study group covering blood boron from low (< 100 ng B/g blood, n = 143) to high (> 150 ng B/g blood, n = 27) concentrations. The mean blood boron concentration and the mean estimated daily boron exposure of the high exposure group was 274.58 (151.81-975.66) ng B/g blood and 24.67 (10.47-57.86) mg B/day, respectively. In spite of the high level of daily boron exposure, boron-mediated adverse effects on induced abortion, spontaneous abortion (miscarriage), stillbirth, infant death, neonatal death, early neonatal death, preterm birth, congenital anomalies, sex ratio and birth weight of newborns were not observed.}, language = {en} } @article{BasaranDuyduUstundagetal.2019, author = {Basaran, Nursen and Duydu, Yalcin and Ustundag, Aylin and Taner, Gokce and Aydin, Sevtap and Anlar, Hatice Gul and Yalcin, Can {\"O}zg{\"u}r and Bacanli, Merve and Aydos, Kaan and Atabekoglu, Cem Somer and Golka, Klaus and Ickstadt, Katja and Schwerdtle, Tanja and Werner, Matthias and Meyer, S{\"o}ren and Bolt, Hermann M.}, title = {Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions}, series = {Mutation Research/Genetic Toxicology and Environmental Mutagenesis}, volume = {843}, journal = {Mutation Research/Genetic Toxicology and Environmental Mutagenesis}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1383-5718}, doi = {10.1016/j.mrgentox.2018.12.013}, pages = {33 -- 39}, year = {2019}, abstract = {Industrial production and use of boron compounds have increased during the last decades, especially for the manufacture of borosilicate glass, fiberglass, metal alloys and flame retardants. This study was conducted in two districts of Balikesir; Bandirma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandirma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandirma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in the DNA damage in blood, sperm and buccal cells was observed in the residents exposed to boron both occupationally and environmentally (p = 0.861) for Comet test in the sperm samples, p = 0.116 for Comet test in the lymphocyte samples, p = 0.042 for micronucleus (MN) test, p = 0.955 for binucleated cells (BN), p = 1.486 for condensed chromatin (CC), p = 0.455 for karyorrhectic cells (KHC), p = 0.541 for karyolitic cells (KLY), p = 1.057 for pyknotic cells (PHC), p = 0.331 for nuclear bud (NBUD)). No correlations were seen between blood boron levels and tail intensity values of the sperm samples, lymphocyte samples, frequencies of MN, BN, KHC, KYL, PHC and NBUD. The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.}, language = {en} } @article{DuyduBasaranYalcinetal.2019, author = {Duydu, Yalcin and Basaran, Nursen and Yalcin, Can {\"O}zg{\"u}r and Ustundag, Aylin and Aydin, Sevtap and Anlar, Hatice Gul and Bacanli, Merve and Aydos, Kaan and Atabekoglu, Cem Somer and Golka, Klaus and Ickstadt, Katja and Schwerdtle, Tanja and Werner, Matthias and Bolt, Hermann M.}, title = {Boron-exposed male workers in Turkey}, series = {Archives of toxicology : official journal of EUROTOX}, volume = {93}, journal = {Archives of toxicology : official journal of EUROTOX}, number = {3}, publisher = {Springer}, address = {Heidelberg}, issn = {0340-5761}, doi = {10.1007/s00204-019-02391-z}, pages = {743 -- 751}, year = {2019}, abstract = {Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 +/- 18.32 mg B/day, 1643.23 +/- 965.44 ng B/g semen and 553.83 +/- 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.}, language = {en} } @article{BaşaranDuyduUestuendağetal.2019, author = {Ba{\c{s}}aran, Nur{\c{s}}en and Duydu, Yal{\c{c}}{\i}n and {\"U}st{\"u}ndağ, Aylin and Taner, G{\"o}k{\c{c}}e and Aydin Dilsiz, Sevtap and Anlar, Hatice G{\"u}l and Yal{\c{c}}in, Can {\"O}zg{\"u}r and Bacanli, Merve and Golka, Klaus and Schwerdtle, Tanja and Bolt, Hermann M.}, title = {Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females DNA damage in lymphocytes and buccal cells of boron exposed females}, series = {Journal of trace elements in medicine and biology}, volume = {53}, journal = {Journal of trace elements in medicine and biology}, publisher = {Elsevier B.V.}, address = {M{\"u}nchen}, issn = {0946-672X}, doi = {10.1016/j.jtemb.2019.03.004}, pages = {150 -- 153}, year = {2019}, abstract = {Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boronpoor areas was examined in this study. For this purpose, the DNA damage in the lymphocytes and buccal cells of females were assessed by Comet and micronucleus (MN) assays respectively. No significant difference was observed in the DNA damage of the lymphocytes of B exposed groups of female volunteers in Comet assay. Even buccal micronucleus (MN) frequency observed in the high exposure group was significantly lower than the low exposure group (p < 0.05). The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.}, language = {en} } @book{BeckerBenedensDeppeetal.2006, author = {Becker, Ulrich and Benedens, Niels Peter and Deppe, Volker and D{\"u}wel, Martin and Hermann, Klaus and Kluge, Johannes and Liedtke, Frank and Schmidt, J{\"u}rgen and Schmidt, Thorsten Ingo and Baum, Christoph}, title = {Kommunalabgabengesetz f{\"u}r das Land Brandenburg}, series = {Gesetze, Verordnungen, Kommentare}, journal = {Gesetze, Verordnungen, Kommentare}, publisher = {Kommunal- und Schul-Verlag}, address = {Wiesbaden}, isbn = {978-3-8293-0764-2}, year = {2006}, abstract = {Das Kommunalabgabengesetz f{\"u}r das Land Brandenburg (KAG) ist eine f{\"u}r alle Kommunalverwaltungen, Zweckverb{\"a}nde und Anw{\"a}lte wichtige Rechtsmaterie. Den 20 Paragrafen steht eine F{\"u}lle von Fragen nach Auslegung und Anwendung des Gesetzes gegen{\"u}ber, die von der Rechtsprechung mit zahlreichen Entscheidungen beantwortet werden. Mit dem Werk "Kommunalabgabengesetz f{\"u}r das Land Brandenburg" liegt ein umfassender Kommentar vor, der sich mit der Auslegung des brandenburgischen Kommunalabgabengesetzes (KAG) und der dazu ergangenen Rechtsprechung befasst. Die zahlreichsten Gerichtsentscheidungen beinhaltet die Kommentierung zu \S 6 (Benutzungsgeb{\"u}hren) Einerseits darf der Titel f{\"u}r sich in Anspruch nehmen, auch nicht speziell juristisch ausgebildete Nutzer in die Rechtsvorschriften zum KAG Brandenburg einzuf{\"u}hren. Andererseits will es aber auch den mit dem Abgabenrecht befassten Fachleuten in Verwaltungen, Verb{\"a}nden, Gerichten und Kanzleien eine solide Grundlage f{\"u}r m{\"o}glichst rechtssichere Entscheidungen bieten. Der engen r{\"a}umlichen N{\"a}he wegen beinhaltet das Werk die Abgabenrechtlichen Vorschriften des Landes Berlin.}, language = {de} } @article{Goetz2012, author = {Goetz, Klaus Hermann}, title = {How does the EU tick? Five propositions on political time}, isbn = {978-0- 415-69633-3}, year = {2012}, language = {en} } @book{Goetz2007, author = {Goetz, Klaus Hermann}, title = {Zeitpolitik in Europa : Antrittsvorlesung 2007-06-27}, publisher = {Univ.-Bibl.}, address = {Potsdam}, year = {2007}, abstract = {Demokratie bedeutet "Macht auf Zeit", d. h. temporale Machtbegrenzung vermittels regelm{\"a}ßiger Wahlen. Die Wahlzyklen bilden den bestimmenden Rhythmus der Demokratie. Dieser Grundsatz kommt innerhalb der EU nur in sehr abgeschw{\"a}chter Form zum Tragen. Vor diesem Hintergrund widmet sich die Vorlesung der Frage, welche Funktionen politische Zeit im politischen System der EU erf{\"u}llt; welche besonderen Zeitregeln und -horizonte bestimmend sind; und wie sich die Eigenzeit der EU auf den Rhythmus der Demokratie in den Mitgliedsstaaten auswirkt.}, language = {de} } @article{GoetzMeyerSahling2009, author = {Goetz, Klaus Hermann and Meyer-Sahling, Jan-Hinrik}, title = {Political time in the EU : dimensions, perspectives, theories}, issn = {1350-1763}, doi = {10.1080/13501760802589198}, year = {2009}, abstract = {The manner in which time is institutionalized is critical to how a political system works. Terms, time budgets and time horizons of collective and individual political actors; rights over timing, sequencing and speed in decision- making; and the temporal properties of policy matter to the distribution of power; efficiency and effectiveness of policy-making; and democratic legitimacy. This article makes a case for the systematic study of political time in the European Union (EU) - both as an independent and a dependent variable - and highlights the analytical value-added of a time-centred analysis. The article discusses previous scholarship on the institutionalization of political time and its consequences along the dimensions of polity, politics and policy; and then reviews dominant perspectives on political time, which centre on power, system performance and legitimacy. These perspectives tie in with diverse theoretical traditions in the study of the EU. Taken together, dimensions, perspectives and theories help to guide time-centred analyses of the EU political system.}, language = {en} } @article{GoetzMeyerSahling2012, author = {Goetz, Klaus Hermann and Meyer-Sahling, Jan-Hinrik}, title = {Political time in the EU: dimensions, perspectives, theories}, isbn = {978-0- 415-69633-3}, year = {2012}, language = {en} } @article{MeyerSahlingGoetz2012, author = {Meyer-Sahling, Jan-Hinrik and Goetz, Klaus Hermann}, title = {The EU timescape : from notion to research agenda}, isbn = {978-0- 415-69633-3}, year = {2012}, language = {en} } @article{Goetz2014, author = {Goetz, Klaus Hermann}, title = {A question of time: responsive and responsible democratic politics}, series = {West European politics}, volume = {37}, journal = {West European politics}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0140-2382}, doi = {10.1080/01402382.2014.887880}, pages = {379 -- 399}, year = {2014}, abstract = {Since 2008, European crisis politics have thrown the importance of time in democracy into sharp relief. The need for rapid action by national authorities, the EU and international organisations conflicts with the time-consuming nature of democratic deliberation; short-term political firefighting has given little consideration to the long-term sustainability and time consistency of policies; and decentralised decisions threaten effective synchronisation within multi-level governance systems. This article suggests that democratic politics requires a balance between the temporal characteristics of responsive and responsible politics. The timeframe for responsive politics is shaped by electoral cycles that encourage speedy action; short-term lags between political choices and their effects; and temporal discretion of decision-makers. The timeframe for responsible politics is characterised by time-consuming procedures; solutions that take time to unfold and are sustainable in the longer term; and the purposive synchronisation amongst actors and across policy domains and levels of policy-making. The finely balanced temporal constitution of democracy has been challenged in two fundamental ways. First, as the ability of decision-makers to work within the time limits of their mandates and to respond to the temporal expectations of the electorate decreases, the temporal ties that ensure the responsiveness of political authority to the electorate weaken. Second, the distinct temporal qualities of majoritarian and non-majoritarian institutions that encourage responsibility are called into question. Consequently, political time in Europe runs the risk of becoming both less responsive and less responsible.}, language = {en} } @misc{DuyduBasaranAydinetal.2017, author = {Duydu, Yalcin and Basaran, Nursen and Aydin, Sevtap and Ustundag, Aylin and Goktas, Hatica Gul and Yalcin, Can {\"O}zg{\"u}r and Bacanli, Merve and Sarigol, Zehra and Aydos, Kaan and Atabekoglu, Cem Somer and Schwerdtle, Tanja and Golka, Klaus and Ickstadt, Katja and Bolt, Hermann M.}, title = {Investigation of boron mediated reproductive and developmental effects in highly boron exposed population}, series = {Toxicology letters}, volume = {280}, journal = {Toxicology letters}, publisher = {Elsevier}, address = {Clare}, issn = {0378-4274}, doi = {10.1016/j.toxlet.2017.07.259}, pages = {S94 -- S94}, year = {2017}, language = {en} }