@article{KlausGzik1997, author = {Klaus, Stefanie and Gzik, Axel}, title = {Aminos{\"a}urenmuster in Wurzeln von Agrostis stolonifera L}, year = {1997}, language = {de} } @article{KlausGzik1999, author = {Klaus, Stefanie and Gzik, Axel}, title = {Ver{\"a}nderungen im Zuckergehalt der Wurzeln von Feuchtwiesengr{\"a}sern unter osmotischem Stress}, year = {1999}, language = {de} } @book{BergmannEhrhartHammetal.2001, author = {Bergmann, Stephan and Ehrhart, Wolfgang and Hamm, Brigitte and Hasse, Jana and Hedrich, Klaus-J{\"u}rgen and Obser, Andreas and Schurer, Stefanie and T{\"o}nnies, Sibylle}, title = {Bilanz ein Jahr nach dem Millennium}, series = {Potsdamer UNO-Konferenzen}, journal = {Potsdamer UNO-Konferenzen}, number = {2}, editor = {Klein, Eckart and Volger, Helmut}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-72403}, publisher = {Universit{\"a}t Potsdam}, pages = {95}, year = {2001}, abstract = {Die ersten beiden Konferenzen des Forschungskreises Vereinte Nationen im Dezember 1999 und im Juni 2000 in der Universit{\"a}t Potsdam standen im Zeichen des interdisziplin{\"a}ren Dialogs in der UN-Forschung zwischen V{\"o}lkerrechts- und Politikwissenschaft und dienten zugleich der Standortbestimmung der deutschen UN-Forschung im internationalen Kontext. Die dritte Konferenz des Forschungskreises, die am 29. und 30. Juni 2001 wiederum in den R{\"a}umen der Juristischen Fakult{\"a}t der Universit{\"a}t Potsdam stattfand, widmete sich der Bilanz der Arbeit der Vereinten Nationen ein Jahr nach dem Milleniumsgipfel 2000 in New York in ihren Hauptaufgabengebieten sowie der deutschen UN-Politik in diesem Kontext. Die in dieser Brosch{\"u}re ver{\"o}ffentlichten Referate der dritten Konferenz spiegeln zusammen mit den Diskussionen, die zusammenfassend dargestellt werden, die weitreichenden strukturellen Probleme, denen sich die Vereinten Nationen durch die Prozesse der Globalisierung in der Friedenssicherung, beim Schutz der Menschenrechte und in der multilateralen Entwicklungszusammenarbeit ausgesetzt sehen. Sie stellen eine erste Evaluation der Reformmaßnahmen dar, die seit dem Milleniumsgipfel beschlossen wurden. Zugleich verdeutlichen sie die enge Wechselbeziehung zwischen der Arbeit der Weltorganisation und der nationalen Außenpolitik ihrer Mitgliedsl{\"a}nder, wie sie sich am Beispiel der Bundesrepublik Deutschland zeigt.}, language = {de} } @article{FernandoDrescherDeubeletal.2018, author = {Fernando, Raquel and Drescher, Cathleen and Deubel, Stefanie and Jung, Tobias and Ost, Mario and Klaus, Susanne and Grune, Tilman and Castro, Jose Pedro}, title = {Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage}, series = {Experimental gerontology}, volume = {117}, journal = {Experimental gerontology}, publisher = {Elsevier}, address = {Oxford}, issn = {0531-5565}, doi = {10.1016/j.exger.2018.10.018}, pages = {45 -- 52}, year = {2018}, abstract = {The skeletal muscle is a crucial tissue for maintaining whole body homeostasis. Aging seems to have a disruptive effect on skeletal muscle homeostasis including proteostasis. However, how aging specifically impacts slow and fast twitch fiber types remains elusive. Muscle proteostasis is largely maintained by the proteasomal system. Here we characterized the proteasomal system in two different fiber types, using a non-sarcopenic aging model. By analyzing the proteasomal activity and amount, as well as the polyubiquitinated proteins and the level of protein oxidation in Musculus soleus (Sol) and Musculus extensor digitorum longus (EDL), we found that the slow twitch Sol muscle shows an overall higher respiratory and proteasomal activity in young and old animals. However, especially during aging the fast twitch EDL muscle reduces protein oxidation by an increase of antioxidant capacity. Thus, under adaptive non-sarcopenic conditions, the two fibers types seem to have different strategies to avoid age-related changes.}, language = {en} } @article{KlausMuellervanWickerenetal.2022, author = {Klaus, Benita and M{\"u}ller, Patrick and van Wickeren, Nora and Dordevic, Milos and Schmicker, Marlen and Zdunczyk, Yael and Brigadski, Tanja and Lessmann, Volkmar and Vielhaber, Stefan and Schreiber, Stefanie and M{\"u}ller, Notger Germar}, title = {Structural and functional brain alterations in patients with myasthenia gravis}, series = {Brain communications}, volume = {4}, journal = {Brain communications}, number = {1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {2632-1297}, doi = {10.1093/braincomms/fcac018}, pages = {12}, year = {2022}, abstract = {Myasthenia gravis is an autoimmune disease affecting neuromuscular transmission and causing skeletal muscle weakness. Additionally, systemic inflammation, cognitive deficits and autonomic dysfunction have been described. However, little is known about myasthenia gravis-related reorganization of the brain. In this study, we thus investigated the structural and functional brain changes in myasthenia gravis patients. Eleven myasthenia gravis patients (age: 70.64 +/- 9.27; 11 males) were compared to age-, sex- and education-matched healthy controls (age: 70.18 +/- 8.98; 11 males). Most of the patients (n = 10, 0.91\%) received cholinesterase inhibitors. Structural brain changes were determined by applying voxel-based morphometry using high-resolution T-1-weighted sequences. Functional brain changes were assessed with a neuropsychological test battery (including attention, memory and executive functions), a spatial orientation task and brain-derived neurotrophic factor blood levels. Myasthenia gravis patients showed significant grey matter volume reductions in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. Furthermore, myasthenia gravis patients showed significantly lower performance in executive functions, working memory (Spatial Span, P = 0.034, d = 1.466), verbal episodic memory (P = 0.003, d = 1.468) and somatosensory-related spatial orientation (Triangle Completion Test, P = 0.003, d = 1.200). Additionally, serum brain-derived neurotrophic factor levels were significantly higher in myasthenia gravis patients (P = 0.001, d = 2.040). Our results indicate that myasthenia gravis is associated with structural and functional brain alterations. Especially the grey matter volume changes in the cingulate gyrus and the inferior parietal lobe could be associated with cognitive deficits in memory and executive functions. Furthermore, deficits in somatosensory-related spatial orientation could be associated with the lower volumes in the inferior parietal lobe. Future research is needed to replicate these findings independently in a larger sample and to investigate the underlying mechanisms in more detail. Klaus et al. compared myasthenia gravis patients to matched healthy control subjects and identified functional alterations in memory functions as well as structural alterations in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus.}, language = {en} }