@article{LeongRaffeinerSpintietal.2022,
  author    = {Leong, Jia Xuan and Raffeiner, Margot and Spinti, Daniela and Langin, Gautier and Franz-Wachtel, Mirita and Guzman, Andrew R. and Kim, Jung-Gun and Pandey, Pooja and Minina, Alyona E. and Macek, Boris and Hafren, Anders and Bozkurt, Tolga O. and Mudgett, Mary Beth and B{\"o}rnke, Frederik and Hofius, Daniel and Uestuen, Suayib},
  title     = {A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component},
  series = {The EMBO journal},
  volume    = {41},
  journal   = {The EMBO journal},
  number    = {13},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1460-2075},
  doi       = {10.15252/embj.2021110352},
  pages     = {17},
  year      = {2022},
  abstract  = {Beyond its role in cellular homeostasis, autophagy plays anti- and promicrobial roles in host-microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense-related autophagy in plant-bacteria interactions.},
  language  = {en}
}