@phdthesis{Laemke2015,
  author    = {L{\"a}mke, J{\"o}rn},
  title     = {Determining the future in the past},
  school      = {Universit{\"a}t Potsdam},
  pages     = {149},
  year      = {2015},
  language  = {en}
}
@article{LiuLaemkeLinetal.2018,
  author    = {Liu, Hsiang-chin and L{\"a}mke, J{\"o}rn and Lin, Siou-ying and Hung, Meng-Ju and Liu, Kuan-Ming and Charng, Yee-yung and B{\"a}urle, Isabel},
  title     = {Distinct heat shock factors and chromatin modifications mediate the organ-autonomous transcriptional memory of heat stress},
  series = {The plant journal},
  volume    = {95},
  journal   = {The plant journal},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0960-7412},
  doi       = {10.1111/tpj.13958},
  pages     = {401 -- 413},
  year      = {2018},
  abstract  = {Plants can be primed by a stress cue to mount a faster or stronger activation of defense mechanisms upon subsequent stress. A crucial component of such stress priming is the modified reactivation of genes upon recurring stress; however, the underlying mechanisms of this are poorly understood. Here, we report that dozens of Arabidopsis thaliana genes display transcriptional memory, i.e. stronger upregulation after a recurring heat stress, that lasts for at least 3 days. We define a set of transcription factors involved in this memory response and show that the transcriptional memory results in enhanced transcriptional activation within minutes of the onset of a heat stress cue. Further, we show that the transcriptional memory is active in all tissues. It may last for up to a week, and is associated during this time with histone H3 lysine 4 hypermethylation. This transcriptional memory is cis-encoded, as we identify a promoter fragment that confers memory onto a heterologous gene. In summary, heat-induced transcriptional memory is a widespread and sustained response, and our study provides a framework for future mechanistic studies of somatic stress memory in higher plants.},
  language  = {en}
}
@misc{LaemkeBaeurle2017,
  author    = {L{\"a}mke, J{\"o}rn and B{\"a}urle, Isabel},
  title     = {Epigenetic and chromatin-based mechanisms in environmental stress adaptation and stress memory in plants},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {792},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43623},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-436236},
  pages     = {11},
  year      = {2017},
  abstract  = {Plants frequently have to weather both biotic and abiotic stressors, and have evolved sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications, nucleosome positioning, and DNA methylation have been recognized as important components in these adaptations. Given their potential epigenetic nature, such modifications may provide a mechanistic basis for a stress memory, enabling plants to respond more efficiently to recurring stress or even to prepare their offspring for potential future assaults. In this review, we discuss both the involvement of chromatin in stress responses and the current evidence on somatic, intergenerational, and transgenerational stress memory.},
  language  = {en}
}
@article{LaemkeUnsicker2018,
  author    = {L{\"a}mke, J{\"o}rn. S. and Unsicker, Sybille Barbara},
  title     = {Phytochemical variation in treetops},
  series = {Oecologia},
  volume    = {187},
  journal   = {Oecologia},
  number    = {2},
  publisher = {Springer},
  address   = {New York},
  issn      = {0029-8549},
  doi       = {10.1007/s00442-018-4087-5},
  pages     = {377 -- 388},
  year      = {2018},
  abstract  = {The interaction of plants and their herbivorous opponents has shaped the evolution of an intricate network of defences and counter-defences for millions of years. The result is an astounding diversity of phytochemicals and plant strategies to fight and survive. Trees are specifically challenged to resist the plethora of abiotic and biotic stresses due to their dimension and longevity. Here, we review the recent literature on the consequences of phytochemical variation in trees on insect-tree-herbivore interactions. We discuss the importance of genotypic and phenotypic variation in tree defence against insects and suggest some molecular mechanisms that might bring about phytochemical diversity in crowns of individual trees.},
  language  = {en}
}
@article{LaemkeBrzezinkaAltmannetal.2016,
  author    = {L{\"a}mke, J{\"o}rn and Brzezinka, Krzysztof and Altmann, Simone and B{\"a}urle, Isabel},
  title     = {A hit-and-run heat shock factor governs sustained histone methylation and transcriptional stress memory},
  series = {The EMBO journal},
  volume    = {35},
  journal   = {The EMBO journal},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0261-4189},
  doi       = {10.15252/embj.201592593},
  pages     = {162 -- 175},
  year      = {2016},
  abstract  = {In nature, plants often encounter chronic or recurring stressful conditions. Recent results indicate that plants can remember a past exposure to stress to be better prepared for a future stress incident. However, the molecular basis of this is poorly understood. Here, we report the involvement of chromatin modifications in the maintenance of acquired thermotolerance (heat stress [HS] memory). HS memory is associated with the accumulation of histone H3 lysine 4 di- and trimethylation at memory-related loci. This accumulation outlasts their transcriptional activity and marks them as recently transcriptionally active. High accumulation of H3K4 methylation is associated with hyper-induction of gene expression upon a recurring HS. This transcriptional memory and the sustained accumulation of H3K4 methylation depend on HSFA2, a transcription factor that is required for HS memory, but not initial heat responses. Interestingly, HSFA2 associates with memory-related loci transiently during the early stages following HS. In summary, we show that transcriptional memory after HS is associated with sustained H3K4 hyper-methylation and depends on a hit-and-run transcription factor, thus providing a molecular framework for HS memory.},
  language  = {en}
}
@article{LaemkeBaeurle2017,
  author    = {L{\"a}mke, J{\"o}rn and B{\"a}urle, Isabel},
  title     = {Epigenetic and chromatin-based mechanisms in environmental stress adaptation and stress memory in plants},
  series = {Genome biology : biology for the post-genomic era},
  volume    = {18},
  journal   = {Genome biology : biology for the post-genomic era},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1474-760X},
  doi       = {10.1186/s13059-017-1263-6},
  pages     = {8685 -- 8693},
  year      = {2017},
  abstract  = {Plants frequently have to weather both biotic and abiotic stressors, and have evolved sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications, nucleosome positioning, and DNA methylation have been recognized as important components in these adaptations. Given their potential epigenetic nature, such modifications may provide a mechanistic basis for a stress memory, enabling plants to respond more efficiently to recurring stress or even to prepare their offspring for potential future assaults. In this review, we discuss both the involvement of chromatin in stress responses and the current evidence on somatic, intergenerational, and transgenerational stress memory.},
  language  = {en}
}
@article{FriedrichOberkoflerTrindadeetal.2021,
  author    = {Friedrich, Thomas and Oberkofler, Vicky and Trindade, In{\^e}s and Altmann, Simone and Brzezinka, Krzysztof and L{\"a}mke, J{\"o}rn S. and Gorka, Michal and Kappel, Christian and Sokolowska, Ewelina and Skirycz, Aleksandra and Graf, Alexander and B{\"a}urle, Isabel},
  title     = {Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis},
  series = {Nature Communications},
  volume    = {12},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature Publishing Group UK},
  address   = {[London]},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-021-23786-6},
  pages     = {15},
  year      = {2021},
  abstract  = {Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days (HS memory) and involves the sustained induction of memory-related genes. Here we show that FORGETTER3/ HEAT SHOCK TRANSCRIPTION FACTOR A3 (FGT3/HSFA3) is specifically required for physiological HS memory and maintaining high memory-gene expression during the days following a HS exposure. HSFA3 mediates HS memory by direct transcriptional activation of memory-related genes after return to normal growth temperatures. HSFA3 binds HSFA2, and in vivo both proteins form heteromeric complexes with additional HSFs. Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation. In summary, our work defines the major HSF complex controlling transcriptional memory and elucidates the in vivo dynamics of HSF complexes during somatic stress memory. Moderate heat stress primes plants to acquire tolerance to subsequent, more severe heat stress. Here the authors show that the HSFA3 transcription factor forms a heteromeric complex with HSFA2 to sustain activated transcription of genes required for acquired thermotolerance by promoting H3K4 hyper-methylation.},
  language  = {en}
}