@article{DiekmannAndresBeckeretal.2019, author = {Diekmann, Martin and Andres, Christian and Becker, Thomas and Bennie, Jonathan and Blueml, Volker and Bullock, James M. and Culmsee, Heike and Fanigliulo, Miriam and Hahn, Annett and Heinken, Thilo and Leuschner, Christoph and Luka, Stefanie and Meissner, Justus and M{\"u}ller, Josef and Newton, Adrian and Peppler-Lisbach, Cord and Rosenthal, Gert and van den Berg, Leon J. L. and Vergeer, Philippine and Wesche, Karsten}, title = {Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe}, series = {Journal of vegetation science}, volume = {30}, journal = {Journal of vegetation science}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {1100-9233}, doi = {10.1111/jvs.12727}, pages = {187 -- 202}, year = {2019}, abstract = {Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species.}, language = {en} } @article{VogelKamitzHallahanetal.2018, author = {Vogel, Heike and Kamitz, Anne and Hallahan, Nicole and Lebek, Sandra and Schallschmidt, Tanja and Jonas, Wenke and J{\"a}hnert, Markus and Gottmann, Pascal and Zellner, Lisa and Kanzleiter, Timo and Damen, Mareike and Altenhofen, Delsi and Burkhardt, Ralph and Renner, Simone and Dahlhoff, Maik and Wolf, Eckhard and M{\"u}ller, Timo Dirk and Bl{\"u}her, Matthias and Joost, Hans-Georg and Chadt, Alexandra and Al-Hasani, Hadi and Sch{\"u}rmann, Annette}, title = {A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes}, series = {Human molecular genetics}, volume = {27}, journal = {Human molecular genetics}, number = {17}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0964-6906}, doi = {10.1093/hmg/ddy217}, pages = {3099 -- 3112}, year = {2018}, abstract = {To explore the genetic determinants of obesity and Type 2 diabetes (T2D), the German Center for Diabetes Research (DZD) conducted crossbreedings of the obese and diabetes-prone New Zealand Obese mouse strain with four different lean strains (B6, DBA, C3H, 129P2) that vary in their susceptibility to develop T2D. Genome-wide linkage analyses localized more than 290 quantitative trait loci (QTL) for obesity, 190 QTL for diabetes-related traits and 100 QTL for plasma metabolites in the out-cross populations. A computational framework was developed that allowed to refine critical regions and to nominate a small number of candidate genes by integrating reciprocal haplotype mapping and transcriptome data. The efficiency of the complex procedure was demonstrated for one obesity QTL. The genomic interval of 35 Mb with 502 annotated candidate genes was narrowed down to six candidates. Accordingly, congenic mice retained the obesity phenotype owing to an interval that contains three of the six candidate genes. Among these the phospholipase PLA2G4A exhibited an elevated expression in adipose tissue of obese human subjects and is therefore a critical regulator of the obesity locus. Together, our broad and complex approach demonstrates that combined- and comparative-cross analysis exhibits improved mapping resolution and represents a valid tool for the identification of disease genes.}, language = {en} } @article{WieseMayrKraemeretal.2017, author = {Wiese, Heike and Mayr, Katharina and Kr{\"a}mer, Philipp and Seeger, Patrick and M{\"u}ller, Hans-Georg and Mezger, Verena}, title = {Changing teachers' attitudes towards linguistic diversity}, series = {International Journal of Applied Linguistics}, volume = {27}, journal = {International Journal of Applied Linguistics}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {0802-6106}, doi = {10.1111/ijal.12121}, pages = {198 -- 220}, year = {2017}, abstract = {We discuss an intervention programme for kindergarten and school teachers' continuing education in Germany that targets biases against language outside a perceived monolingual 'standard' and its speakers. The programme combines anti-bias methods relating to linguistic diversity with objectives of raising critical language awareness. Evaluation through teachers' workshops in Berlin and Brandenburg points to positive and enduring attitudinal changes in participants, but not in control groups that did not attend workshops, and effects were independent of personal variables gender and teaching subject and only weakly associated with age. We relate these effects to such programme features as indirect and inclusive methods that foster active engagement, and the combination of 'safer' topics targeting attitudes towards linguistic structures with more challenging ones dealing with the discrimination of speakers.}, language = {en} } @article{MuellerWieseMayretal.2015, author = {M{\"u}ller, Hans-Georg and Wiese, Heike and Mayr, Katharina and Kr{\"a}mer, Philipp and Seeger, Patrick and Mezger, Verena}, title = {Changing teachers' attitudes towards linguistic diversity}, series = {International Journal of Applied Linguistics}, volume = {27}, journal = {International Journal of Applied Linguistics}, number = {1}, pages = {198 -- 220}, year = {2015}, abstract = {We discuss an intervention programme for kindergarten and school teachers' continuing education in Germany that targets biases against language outside a perceived monolingual 'standard' and its speakers. The programme combines anti-bias methods relating to linguistic diversity with objectives of raising critical language awareness. Evaluation through teachers' workshops in Berlin and Brandenburg points to positive and enduring attitudinal changes in participants, but not in control groups that did not attend workshops, and effects were independent of personal variables gender and teaching subject and only weakly associated with age. We relate these effects to such programme features as indirect and inclusive methods that foster active engagement, and the combination of 'safer' topics targeting attitudes towards linguistic structures with more challenging ones dealing with the discrimination of speakers.}, language = {en} } @article{BatsiosIshikawaAnkerholdRothetal.2019, author = {Batsios, Petros and Ishikawa-Ankerhold, Hellen Christina and Roth, Heike and Schleicher, Michael and Wong, Catherine C. L. and M{\"u}ller-Taubenberger, Annette}, title = {Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum}, series = {Molecular biology of the cell : the official publication of the American Society for Cell Biology}, volume = {30}, journal = {Molecular biology of the cell : the official publication of the American Society for Cell Biology}, number = {4}, publisher = {American Society for Cell Biology}, address = {Bethesda}, issn = {1059-1524}, doi = {10.1091/mbc.E18-02-0132}, pages = {453 -- 466}, year = {2019}, abstract = {The highly conserved enzyme arginyl-tRNA-protein transferase (Ate1) mediates arginylation, a posttranslational modification that is only incompletely understood at its molecular level. To investigate whether arginylation affects actin-dependent processes in a simple model organism, Dictyostelium discoideum, we knocked out the gene encoding Ate1 and characterized the phenotype of ate1-null cells. Visualization of actin cytoskeleton dynamics by live-cell microscopy indicated significant changes in comparison to wild-type cells. Ate1-null cells were almost completely lacking focal actin adhesion sites at the substrate-attached surface and were only weakly adhesive. In two-dimensional chemotaxis assays toward folate or cAMP, the motility of ate1-null cells was increased. However, in three-dimensional chemotaxis involving more confined conditions, the motility of ate1-null cells was significantly reduced. Live-cell imaging showed that GFP-tagged Ate1 rapidly relocates to sites of newly formed actin-rich protrusions. By mass spectrometric analysis, we identified four arginylation sites in the most abundant actin isoform of Dictyostelium, in addition to arginylation sites in other actin isoforms and several actin-binding proteins. In vitro polymerization assays with actin purified from ate1-null cells revealed a diminished polymerization capacity in comparison to wild-type actin. Our data indicate that arginylation plays a crucial role in the regulation of cytoskeletal activities.}, language = {en} } @article{HinzGuzmanMueller2021, author = {Hinz, Carsten and Guzm{\´a}n, Ren{\´a}n A. Oliva and M{\"u}ller, Heike}, title = {Zur F{\"o}rderung des wissenschaftlichen Nachwuchses in der haushaltsbezogenen Bildung}, series = {Haushalt in Bildung und Forschung}, volume = {10}, journal = {Haushalt in Bildung und Forschung}, number = {1}, publisher = {Budrich}, address = {Opladen}, doi = {10.3224/hibifo.v10i1.01}, pages = {3 -- 23}, year = {2021}, abstract = {Wissenschaftlicher Nachwuchs ist bedeutsam f{\"u}r den Erhalt und Ausbau jeder Disziplin. Aktuell gibt es nur wenige empirische Erkenntnisse zur Situation in der haushaltsbezogenen Bildung. Im Beitrag werden ausgew{\"a}hlte Aspekte zur Situation der Nachwuchsf{\"o}rderung skizziert und Ankn{\"u}pfungspunkte f{\"u}r die haushaltsbezogene Bildung vor dem Hintergrund erster Erfahrungen aus der 2019 gegr{\"u}ndeten Nachwuchsgruppe HaBiFo-NEO diskutiert.}, language = {de} } @article{WoehlBruhnBadarBertzetal.2012, author = {W{\"o}hl-Bruhn, Stefanie and Badar, Muhammad and Bertz, Andreas and Tiersch, Brigitte and Koetz, Joachim and Menzel, Henning and M{\"u}ller, Peter P. and Bunjes, Heike}, title = {Comparison of in vitro and in vivo protein release from hydrogel systems}, series = {Journal of controlled release}, volume = {162}, journal = {Journal of controlled release}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-3659}, doi = {10.1016/j.jconrel.2012.05.049}, pages = {127 -- 133}, year = {2012}, abstract = {Hydrogel systems based on hydroxyethyl starch-polyethylene glycol methacrylate (HES-P(EG)(6)MA) or hydroxyethyl starch methacrylate (HES-MA) were used to assess the protein release behavior. Here, we analyzed the in vitro release of FITC-anti-human antibodies incorporated in either HES-P(EG)(6)MA or HES-MA hydrogel delivery systems in PBS or human serum. In addition, hydrogel disks and microparticles prepared from the two polymers were subcutaneously implanted in BALB/c mice. The in vivo release of FITC-IgG was non-invasively monitored by an in vivo imaging system (IVIS 200) over a time period of up to 3 months. The imaging system allowed to asses individual animals over time, therefore only a small number of animals was required to obtain high quality data. The reduction in fluorescence intensity at the site of administration was compared to in vitro release profiles. These investigations demonstrated a sustained release from HES-MA hydrogel disks compared to rapidly degrading HES-P(EG)(6)MA disks and microparticles. The sustained release from HES-MA disks could be further optimized by using increased polymer concentrations. Human serum as in vitro release medium reflected better the in vivo release from HES-P(EG)(6)MA systems than PBS, suggesting that the presence of organic substances like proteins or lipids may play a significant role for the release kinetics.}, language = {en} } @article{PenningMueller2021, author = {Penning, Isabelle and M{\"u}ller, Heike}, title = {Consumer education}, series = {SchoolEducationGateway}, journal = {SchoolEducationGateway}, editor = {SchoolEducationGateway. Europe's online platform for school education,}, year = {2021}, language = {en} } @article{BartschBauerMuelleretal.2019, author = {Bartsch, Silke and Bauer, Katharina and M{\"u}ller, Heike and Penning, Isabelle}, title = {Verbraucherkompetenzen f{\"u}r morgen und durch Lehrkr{\"a}fteweiterbildung heute}, series = {Haushalt in Bildung und Forschung (HiBiFo)}, volume = {8}, journal = {Haushalt in Bildung und Forschung (HiBiFo)}, number = {4}, publisher = {Budrich}, address = {Leverkusen}, issn = {2193-8806}, doi = {10.3224/hibifo.v8i4.06}, pages = {90 -- 103}, year = {2019}, abstract = {Verbraucherbildung ist bundesweit vielf{\"a}ltig in curricularen Vorgaben verankert. Fachfremde Lehrpersonen ben{\"o}tigen Professionalisierungsangebote, um die Verbraucherbildung als Querschnittsaufgabe in ihren F{\"a}chern implementieren zu k{\"o}nnen. Erkenntnisse aus der Professionalisierungsforschung werden daher im Beitrag in Bezug auf das cLEVER-Projekt zusammengetragen, um sie f{\"u}r Fortbildungsangebote nutzbar zu machen.}, language = {de} } @misc{SzameitatKampeEckardtetal.2013, author = {Szameitat, Ulrike and Kampe, Heike and Eckardt, Barbara and G{\"o}rlich, Petra and Haller, Silja and Rost, Sophia and M{\"u}ller, Sarah and S{\"u}tterlin, Sabine and Winter, Nora and J{\"a}ger, Sophie and Zimmermann, Matthias}, title = {Portal = Gesellschaft im Wandel: Zukunftsaufgabe Inklusion}, number = {03/2013}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-44053}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440531}, pages = {42}, year = {2013}, abstract = {Aus dem Inhalt: - Gesellschaft im Wandel: Zukunftsaufgabe Inklusion - Mit Kopf und F{\"u}ßen - Du bist, was du guckst}, language = {de} }