@article{BeerenwinkelSingLengaueretal.2005,
  author    = {Beerenwinkel, Niko and Sing, Tobias and Lengauer, Thomas and Rahnenfuhrer, Joerg and Roomp, Kirsten and Savenkov, Igor and Fischer, Roman and Hoffmann, Daniel and Selbig, Joachim and Korn, Klaus and Walter, Hauke and Berg, Thomas and Braun, Patrick and Faetkenheuer, Gerd and Oette, Mark and Rockstroh, Juergen and Kupfer, Bernd and Kaiser, Rolf and Daeumer, Martin},
  title     = {Computational methods for the design of effective therapies against drug resistant HIV strains},
  year      = {2005},
  abstract  = {The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data},
  language  = {en}
}
@article{TrauthAsratDuesingetal.2019,
  author    = {Trauth, Martin H. and Asrat, Asfawossen and D{\"u}sing, Walter and Foerster, Verena and Kr{\"a}mer, K. Hauke and Marwan, Norbert and Maslin, Mark A. and Sch{\"a}bitz, Frank},
  title     = {Classifying past climate change in the Chew Bahir basin, southern Ethiopia, using recurrence quantification analysis},
  series = {Climate dynamics : observational, theoretical and computational research on the climate system},
  volume    = {53},
  journal   = {Climate dynamics : observational, theoretical and computational research on the climate system},
  number    = {5-6},
  publisher = {Springer},
  address   = {New York},
  issn      = {0930-7575},
  doi       = {10.1007/s00382-019-04641-3},
  pages     = {2557 -- 2572},
  year      = {2019},
  abstract  = {The Chew Bahir Drilling Project (CBDP) aims to test possible linkages between climate and evolution in Africa through the analysis of sediment cores that have recorded environmental changes in the Chew Bahir basin. In this statistical project we consider the Chew Bahir palaeolake to be a dynamical system consisting of interactions between its different components, such as the waterbody, the sediment beneath lake, and the organisms living within and around the lake. Recurrence is a common feature of such dynamical systems, with recurring patterns in the state of the system reflecting typical influences. Identifying and defining these influences contributes significantly to our understanding of the dynamics of the system. Different recurring changes in precipitation, evaporation, and wind speed in the Chew Bahir basin could result in similar (but not identical) conditions in the lake (e.g., depth and area of the lake, alkalinity and salinity of the lake water, species assemblages in the water body, and diagenesis in the sediments). Recurrence plots (RPs) are graphic displays of such recurring states within a system. Measures of complexity were subsequently introduced to complement the visual inspection of recurrence plots, and provide quantitative descriptions for use in recurrence quantification analysis (RQA). We present and discuss herein results from an RQA on the environmental record from six short (< 17 m) sediment cores collected during the CBDP, spanning the last 45 kyrs. The different types of variability and transitions in these records were classified to improve our understanding of the response of the biosphere to climate change, and especially the response of humans in the area.},
  language  = {en}
}