@article{ChipmanFerrierBrenaetal.2014, author = {Chipman, Ariel D. and Ferrier, David E. K. and Brena, Carlo and Qu, Jiaxin and Hughes, Daniel S. T. and Schroeder, Reinhard and Torres-Oliva, Montserrat and Znassi, Nadia and Jiang, Huaiyang and Almeida, Francisca C. and Alonso, Claudio R. and Apostolou, Zivkos and Aqrawi, Peshtewani and Arthur, Wallace and Barna, Jennifer C. J. and Blankenburg, Kerstin P. and Brites, Daniela and Capella-Gutierrez, Salvador and Coyle, Marcus and Dearden, Peter K. and Du Pasquier, Louis and Duncan, Elizabeth J. and Ebert, Dieter and Eibner, Cornelius and Erikson, Galina and Evans, Peter D. and Extavour, Cassandra G. and Francisco, Liezl and Gabaldon, Toni and Gillis, William J. and Goodwin-Horn, Elizabeth A. and Green, Jack E. and Griffiths-Jones, Sam and Grimmelikhuijzen, Cornelis J. P. and Gubbala, Sai and Guigo, Roderic and Han, Yi and Hauser, Frank and Havlak, Paul and Hayden, Luke and Helbing, Sophie and Holder, Michael and Hui, Jerome H. L. and Hunn, Julia P. and Hunnekuhl, Vera S. and Jackson, LaRonda and Javaid, Mehwish and Jhangiani, Shalini N. and Jiggins, Francis M. and Jones, Tamsin E. and Kaiser, Tobias S. and Kalra, Divya and Kenny, Nathan J. and Korchina, Viktoriya and Kovar, Christie L. and Kraus, F. Bernhard and Lapraz, Francois and Lee, Sandra L. and Lv, Jie and Mandapat, Christigale and Manning, Gerard and Mariotti, Marco and Mata, Robert and Mathew, Tittu and Neumann, Tobias and Newsham, Irene and Ngo, Dinh N. and Ninova, Maria and Okwuonu, Geoffrey and Ongeri, Fiona and Palmer, William J. and Patil, Shobha and Patraquim, Pedro and Pham, Christopher and Pu, Ling-Ling and Putman, Nicholas H. and Rabouille, Catherine and Ramos, Olivia Mendivil and Rhodes, Adelaide C. and Robertson, Helen E. and Robertson, Hugh M. and Ronshaugen, Matthew and Rozas, Julio and Saada, Nehad and Sanchez-Gracia, Alejandro and Scherer, Steven E. and Schurko, Andrew M. and Siggens, Kenneth W. and Simmons, DeNard and Stief, Anna and Stolle, Eckart and Telford, Maximilian J. and Tessmar-Raible, Kristin and Thornton, Rebecca and van der Zee, Maurijn and von Haeseler, Arndt and Williams, James M. and Willis, Judith H. and Wu, Yuanqing and Zou, Xiaoyan and Lawson, Daniel and Muzny, Donna M. and Worley, Kim C. and Gibbs, Richard A. and Akam, Michael and Richards, Stephen}, title = {The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima}, series = {PLoS biology}, volume = {12}, journal = {PLoS biology}, number = {11}, publisher = {PLoS}, address = {San Fransisco}, issn = {1545-7885}, doi = {10.1371/journal.pbio.1002005}, pages = {24}, year = {2014}, abstract = {Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.}, language = {en} } @article{ArridgeAchilleosAgarwaletal.2014, author = {Arridge, Christopher S. and Achilleos, N. and Agarwal, Jessica and Agnor, C. B. and Ambrosi, R. and Andre, N. and Badman, S. V. and Baines, K. and Banfield, D. and Barthelemy, M. and Bisi, M. M. and Blum, J. and Bocanegra-Bahamon, T. and Bonfond, B. and Bracken, C. and Brandt, P. and Briand, C. and Briois, C. and Brooks, S. and Castillo-Rogez, J. and Cavalie, T. and Christophe, B. and Coates, Andrew J. and Collinson, G. and Cooper, J. F. and Costa-Sitja, M. and Courtin, R. and Daglis, I. A. and De Pater, Imke and Desai, M. and Dirkx, D. and Dougherty, M. K. and Ebert, R. W. and Filacchione, Gianrico and Fletcher, Leigh N. and Fortney, J. and Gerth, I. and Grassi, D. and Grodent, D. and Gr{\"u}n, Eberhard and Gustin, J. and Hedman, M. and Helled, R. and Henri, P. and Hess, Sebastien and Hillier, J. K. and Hofstadter, M. H. and Holme, R. and Horanyi, M. and Hospodarsky, George B. and Hsu, S. and Irwin, P. and Jackman, C. M. and Karatekin, O. and Kempf, Sascha and Khalisi, E. and Konstantinidis, K. and Kruger, H. and Kurth, William S. and Labrianidis, C. and Lainey, V. and Lamy, L. L. and Laneuville, Matthieu and Lucchesi, D. and Luntzer, A. and MacArthur, J. and Maier, A. and Masters, A. and McKenna-Lawlor, S. and Melin, H. and Milillo, A. and Moragas-Klostermeyer, Georg and Morschhauser, Achim and Moses, J. I. and Mousis, O. and Nettelmann, N. and Neubauer, F. M. and Nordheim, T. and Noyelles, B. and Orton, G. S. and Owens, Mathew and Peron, R. and Plainaki, C. and Postberg, F. and Rambaux, N. and Retherford, K. and Reynaud, Serge and Roussos, E. and Russell, C. T. and Rymer, Am. and Sallantin, R. and Sanchez-Lavega, A. and Santolik, O. and Saur, J. and Sayanagi, Km. and Schenk, P. and Schubert, J. and Sergis, N. and Sittler, E. C. and Smith, A. and Spahn, Frank and Srama, Ralf and Stallard, T. and Sterken, V. and Sternovsky, Zoltan and Tiscareno, M. and Tobie, G. and Tosi, F. and Trieloff, M. and Turrini, D. and Turtle, E. P. and Vinatier, S. and Wilson, R. and Zarkat, P.}, title = {The science case for an orbital mission to Uranus: Exploring the origins and evolution of ice giant planets}, series = {Planetary and space science}, volume = {104}, journal = {Planetary and space science}, publisher = {Elsevier}, address = {Oxford}, issn = {0032-0633}, doi = {10.1016/j.pss.2014.08.009}, pages = {122 -- 140}, year = {2014}, abstract = {Giant planets helped to shape the conditions we see in the Solar System today and they account for more than 99\% of the mass of the Sun's planetary system. They can be subdivided into the Ice Giants (Uranus and Neptune) and the Gas Giants (Jupiter and Saturn), which differ from each other in a number of fundamental ways. Uranus, in particular is the most challenging to our understanding of planetary formation and evolution, with its large obliquity, low self-luminosity, highly asymmetrical internal field, and puzzling internal structure. Uranus also has a rich planetary system consisting of a system of inner natural satellites and complex ring system, five major natural icy satellites, a system of irregular moons with varied dynamical histories, and a highly asymmetrical magnetosphere. Voyager 2 is the only spacecraft to have explored Uranus, with a flyby in 1986, and no mission is currently planned to this enigmatic system. However, a mission to the uranian system would open a new window on the origin and evolution of the Solar System and would provide crucial information on a wide variety of physicochemical processes in our Solar System. These have clear implications for understanding exoplanetary systems. In this paper we describe the science case for an orbital mission to Uranus with an atmospheric entry probe to sample the composition and atmospheric physics in Uranus' atmosphere. The characteristics of such an orbiter and a strawman scientific payload are described and we discuss the technical challenges for such a mission. This paper is based on a white paper submitted to the European Space Agency's call for science themes for its large-class mission programme in 2013.}, language = {en} } @article{RienksWimmerSanchezBarrigaetal.2019, author = {Rienks, Emile D. L. and Wimmer, S. and Sanchez-Barriga, Jaime and Caha, O. and Mandal, Partha Sarathi and Ruzicka, J. and Ney, A. and Steiner, H. and Volobuev, V. V. and Groiss, H. and Albu, M. and Kothleitner, G. and Michalicka, J. and Khan, S. A. and Minar, J. and Ebert, H. and Bauer, G. and Freyse, Friedrich and Varykhalov, Andrei and Rader, Oliver and Springholz, Gunther}, title = {Large magnetic gap at the Dirac point in Bi2Te3/MnBi2Te4 heterostructures}, series = {Nature : the international weekly journal of science}, volume = {576}, journal = {Nature : the international weekly journal of science}, number = {7787}, publisher = {Nature Publ. Group}, address = {London}, issn = {0028-0836}, doi = {10.1038/s41586-019-1826-7}, pages = {423 -- 428}, year = {2019}, abstract = {Magnetically doped topological insulators enable the quantum anomalous Hall effect (QAHE), which provides quantized edge states for lossless charge-transport applications(1-8). The edge states are hosted by a magnetic energy gap at the Dirac point(2), but hitherto all attempts to observe this gap directly have been unsuccessful. Observing the gap is considered to be essential to overcoming the limitations of the QAHE, which so far occurs only at temperatures that are one to two orders of magnitude below the ferromagnetic Curie temperature, T-C (ref. (8)). Here we use low-temperature photoelectron spectroscopy to unambiguously reveal the magnetic gap of Mn-doped Bi2Te3, which displays ferromagnetic out-of-plane spin texture and opens up only below T-C. Surprisingly, our analysis reveals large gap sizes at 1 kelvin of up to 90 millielectronvolts, which is five times larger than theoretically predicted(9). Using multiscale analysis we show that this enhancement is due to a remarkable structure modification induced by Mn doping: instead of a disordered impurity system, a self-organized alternating sequence of MnBi2Te4 septuple and Bi2Te3 quintuple layers is formed. This enhances the wavefunction overlap and size of the magnetic gap(10). Mn-doped Bi2Se3 (ref. (11)) and Mn-doped Sb2Te3 form similar heterostructures, but for Bi2Se3 only a nonmagnetic gap is formed and the magnetization is in the surface plane. This is explained by the smaller spin-orbit interaction by comparison with Mn-doped Bi2Te3. Our findings provide insights that will be crucial in pushing lossless transport in topological insulators towards room-temperature applications.}, language = {en} } @article{EbertTrauth2015, author = {Ebert, Thomas and Trauth, Martin H.}, title = {Semi-automated detection of annual laminae (varves) in lake sediments using a fuzzy logic algorithm}, series = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, volume = {435}, journal = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0031-0182}, doi = {10.1016/j.palaeo.2015.05.024}, pages = {272 -- 282}, year = {2015}, abstract = {Annual laminae (varves) in lake sediments are typically visually identified, measured and counted, although numerous attempts have been made to automate this process. The reason for the failure of most of these automated algorithms for varve counting is the complexity of the seasonal laminations, typically rich in lateral fades variations and internal heterogeneities. In the manual counting of varves, the investigator acquired and interpreted flexible numbers of complex decision criteria to understand whether a particular simple lamination is a varve or not. Fuzzy systems simulate the flexible decision making process in a computer by introducing a smooth transition between true varve and false varve. In our investigation, we use an adaptive neuro fuzzy inference system (ANFIS) to detect varves on the basis of a digital image of the sediment. The results of the application of the ANFIS to laminated sediments from the Meerfelder Maar (Eifel, Germany) and from a landslide-dammed lake in the Quebrada de Cafayate of Argentina are compared with manual varve counts and possible reasons for the differences are discussed. (C) 2015 Elsevier B.V. All rights reserved.}, language = {en} } @article{WittBornhorstMitzeetal.2017, author = {Witt, B. and Bornhorst, Julia and Mitze, H. and Ebert, Franziska and Meyer, S. and Francesconi, Kevin A. and Schwerdtle, Tanja}, title = {Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures}, series = {Metallomics : integrated biometal science}, volume = {9}, journal = {Metallomics : integrated biometal science}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-5901}, doi = {10.1039/c7mt00036g}, pages = {442 -- 446}, year = {2017}, abstract = {Arsenic-containing hydrocarbons (AsHCs), natural products found in seafood, have recently been shown to exert toxic effects in human neurons. In this study we assessed the toxicity of three AsHCs in cultured human astrocytes. Due to the high cellular accessibility and substantial toxicity observed astrocytes were identified as further potential brain target cells for arsenolipids. Thereby, the AsHCs exerted a 5-19-fold higher cytotoxicity in astrocytes as compared to arsenite. Next we compared the toxicity of the arsenicals in a co-culture model of the respective human astrocytes and neurons. Notably the AsHCs did not show any substantial toxic effects in the co-culture, while arsenite did. The arsenic accessibility studies indicated that in the co-culture astrocytes protect neurons against cellular arsenic accumulation especially after incubation with arsenolipids. In summary, these data underline the importance of the glial-neuron interaction when assessing the in vitro neurotoxicity of new unclassified metal species.}, language = {en} }