@article{LiLuTsuprykovetal.2018, author = {Li, Jian and Lu, Yong-Ping and Tsuprykov, Oleg and Hasan, Ahmed Abdallah Abdalrahman Mohamed and Reichetzeder, Christoph and Tian, Mei and Zhang, Xiao Li and Zhang, Qin and Sun, Guo-Ying and Guo, Jingli and Gaballa, Mohamed Mahmoud Salem Ahmed and Peng, Xiao-Ning and Lin, Ge and Hocher, Berthold}, title = {Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet}, series = {Diabetologia : journal of the European Association for the Study of Diabetes (EASD)}, volume = {61}, journal = {Diabetologia : journal of the European Association for the Study of Diabetes (EASD)}, number = {8}, publisher = {Springer}, address = {New York}, issn = {0012-186X}, doi = {10.1007/s00125-018-4635-x}, pages = {1862 -- 1876}, year = {2018}, abstract = {Aims/hypothesis Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy. Methods Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After mating, the F0 dams were fed control diet with or without folate during pregnancy.}, language = {en} } @article{LiShenZhangetal.2022, author = {Li, Jian and Shen, Jinhua and Zhang, Xiaoli and Peng, Yangqin and Zhang, Qin and Hu, Liang and Reichetzeder, Christoph and Zeng, Suimin and Li, Jing and Tian, Mei and Gong, Fei and Lin, Ge and Hocher, Berthold}, title = {Risk factors associated with preterm birth after IVF/ICSI}, series = {Scientific reports}, volume = {12}, journal = {Scientific reports}, number = {1}, publisher = {Nature Research}, address = {Berlin}, issn = {2045-2322}, doi = {10.1038/s41598-022-12149-w}, pages = {9}, year = {2022}, abstract = {In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is associated with an increased risk of preterm (33rd-37th gestational week) and early preterm birth (20th-32nd gestational week). The underlying general and procedure related risk factors are not well understood so far. 4328 infertile women undergoing IVF/ICSI were entered into this study. The study population was divided into three groups: (a) early preterm birth group (n = 66), (b) preterm birth group (n = 675) and (c) full-term birth group (n = 3653). Odds for preterm birth were calculated by stepwise multivariate logistic regression analysis. We identified seven independent risk factors for preterm birth and four independent risk factors for early preterm birth. Older (> 39) or younger (< 25) maternal age (OR: 1.504, 95\% CI 1.108-2.042, P = 0.009; OR: 2.125, 95\% CI 1.049-4.304, P = 0.036, respectively), multiple pregnancy (OR: 9.780, 95\% CI 8.014-11.935, P < 0.001; OR: 8.588, 95\% CI 4.866-15.157, P < 0.001, respectively), placenta previa (OR: 14.954, 95\% CI 8.053-27.767, P < 0.001; OR: 16.479, 95\% CI 4.381-61.976, P < 0.001, respectively), and embryo reduction (OR: 3.547, 95\% CI 1.736-7.249, P = 0.001; OR: 7.145, 95\% CI 1.990-25.663, P = 0.003, respectively) were associated with preterm birth and early preterm birth, whereas gestational hypertension (OR: 2.494, 95\% CI 1.770-3.514, P < 0.001), elevated triglycerides (OR: 1.120, 95\% CI 1.011-1.240, P = 0.030) and shorter activated partial thromboplastin time (OR: 0.967, 95\% CI 0.949-0.985, P < 0.001) were associated only with preterm birth. In conclusion, preterm and early preterm birth risk factors in patients undergoing assisted IVF/ICSI are in general similar to those in natural pregnancy. The lack of some associations in the early preterm group was most likely due to the lower number of early preterm birth cases. Only embryo reduction represents an IVF/ICSI specific risk factor.}, language = {en} }