@misc{SinghSeitzEickeretal.2016,
  author    = {Singh, Alka and Seitz, Florian and Eicker, Annette and G{\"u}ntner, Andreas},
  title     = {Water budget analysis within the surrounding of prominent lakes and reservoirs from multi-sensor earth observation data and hydrological models},
  series = {remote sensing},
  journal   = {remote sensing},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-407902},
  pages     = {21},
  year      = {2016},
  abstract  = {The hydrological budget of a region is determined based on the horizontal and vertical water fluxes acting in both inward and outward directions. These integrated water fluxes vary, altering the total water storage and consequently the gravitational force of the region. The time-dependent gravitational field can be observed through the Gravity Recovery and Climate Experiment (GRACE) gravimetric satellite mission, provided that the mass variation is above the sensitivity of GRACE. This study evaluates mass changes in prominent reservoir regions through three independent approaches viz. fluxes, storages, and gravity, by combining remote sensing products, in-situ data and hydrological model outputs using WaterGAP Global Hydrological Model (WGHM) and Global Land Data Assimilation System (GLDAS). The results show that the dynamics revealed by the GRACE signal can be better explored by a hybrid method, which combines remote sensing-based reservoir volume estimates with hydrological model outputs, than by exclusive model-based storage estimates. For the given arid/ semi-arid regions, GLDAS based storage estimations perform better than WGHM.},
  language  = {en}
}
@article{SinghSeitzEickeretal.2016,
  author    = {Singh, Alka and Seitz, Florian and Eicker, Annette and G{\"u}ntner, Andreas},
  title     = {Water Budget Analysis within the Surrounding of Prominent Lakes and Reservoirs from Multi-Sensor Earth Observation Data and Hydrological Models: Case Studies of the Aral Sea and Lake Mead},
  series = {Remote sensing},
  volume    = {8},
  journal   = {Remote sensing},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-4292},
  doi       = {10.3390/rs8110953},
  pages     = {21},
  year      = {2016},
  abstract  = {The hydrological budget of a region is determined based on the horizontal and vertical water fluxes acting in both inward and outward directions. These integrated water fluxes vary, altering the total water storage and consequently the gravitational force of the region. The time-dependent gravitational field can be observed through the Gravity Recovery and Climate Experiment (GRACE) gravimetric satellite mission, provided that the mass variation is above the sensitivity of GRACE. This study evaluates mass changes in prominent reservoir regions through three independent approaches viz. fluxes, storages, and gravity, by combining remote sensing products, in-situ data and hydrological model outputs using WaterGAP Global Hydrological Model (WGHM) and Global Land Data Assimilation System (GLDAS). The results show that the dynamics revealed by the GRACE signal can be better explored by a hybrid method, which combines remote sensing-based reservoir volume estimates with hydrological model outputs, than by exclusive model-based storage estimates. For the given arid/ semi-arid regions, GLDAS based storage estimations perform better than WGHM.},
  language  = {en}
}
@article{SchlagOsterzielOezceliketal.2008,
  author    = {Schlag, Peter M. and Osterziel, Karl Joseph and {\"O}zcelik, Cemil and Scherneck, Siegfried and Wenzel, Katrin and Daskalow, Katjana and Herse, Florian and Seitz, Susanne and Zacharias, Ute and Schenk, J{\"o}rg A. and Schulz, Herbert and H{\"u}bner, Norbert and Micheel, Burkhard},
  title     = {The protein phosphatase 1 inhibitor KEPI is down regulated in breast cancer cell lines and tissues and involved in the regulation of the tumour suppressor EGR1 via the MEK-ERK pathway},
  year      = {2008},
  abstract  = {KEPI is a protein kinase C-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatases. We found no or reduced expression of KEPI in breast cancer cell lines, breast tumors and metastases in comparison to normal breast cell lines and tissues, respectively. KEPI protein expression and ubiquitous localization was detected with a newly generated antibody. Ectopic KEPI expression in MCF7 breast cancer cells induced differential expression of 95 genes, including the up-regulation of the tumor suppressors EGR1 (early growth response 1) and PTEN (phosphatase and tensin homolog), which is regulated by EGR1. We further show that the up-regulation of EGR1 in MCF7/KEPI cells is mediated by MEK-ERK signaling. The inhibition of this pathway by the MEK inhibitor UO126 led to a strong decrease in EGR1 expression in MCF7/KEPI cells. These results reveal a novel role for KEPI in the regulation of the tumor suppressor gene EGR1 via activation of the MEK-ERK MAPK pathway.},
  language  = {en}
}