@article{VoelkerGomezPorrasBeckeretal.2010, author = {Voelker, Camilla and Gomez-Porras, Judith Lucia and Becker, Dirk and Hamamoto, Shin and Uozumi, Nobuyuki and Gambale, Franco and M{\"u}ller-R{\"o}ber, Bernd and Czempinski, Katrin and Dreyer, Ingo}, title = {Roles of tandem-pore K plus channels in plants : a puzzle still to be solved}, issn = {1435-8603}, doi = {10.1111/j.1438-8677.2010.00353.x}, year = {2010}, abstract = {The group of voltage-independent K+ channels in Arabidopsis thaliana consists of six members, five tandem-pore channels (TPK1-TPK5) and a single K-ir-like channel (KCO3). All TPK/KCO channels are located at the vacuolar membrane except for TPK4, which was shown to be a plasma membrane channel in pollen. The vacuolar channels interact with 14-3-3 proteins (also called General Regulating Factors, GRFs), indicating regulation at the level of protein-protein interactions. Here we review current knowledge about these ion channels and their genes, and highlight open questions that need to be urgently addressed in future studies to fully appreciate the physiological functions of these ion channels.}, language = {en} } @article{BeckerGeigerDunkeletal.2004, author = {Becker, Dirk and Geiger, D. and Dunkel, M. and Roller, A. and Bertl, Adam and Latz, A. and Carpaneto, Armando and Dietrich, Peter and Roelfsema, M. R. G. and Voelker, C. and Schmidt, D. and M{\"u}ller-R{\"o}ber, Bernd and Czempinski, Katrin and Hedrich, R.}, title = {AtTPK4, an Arabidopsis tandem-pore K+ channel, poised to control the pollen membrane voltage in a pH- and Ca2+- dependent manner}, issn = {0027-8424}, year = {2004}, abstract = {The Arabidopsis tandem-pore K+ (TPK) channels displaying four transmembrane domains and two pore regions share structural homologies with their animal counterparts of the KCNK family. In contrast to the Shaker-like Arabidopsis channels (six transmembrane domains/one pore region), the functional properties and the biological role of plant TPK channels have not been elucidated yet. Here, we show that AtTPK4 (KCO4) localizes to the plasma membrane and is predominantly expressed in pollen. AtTPK4 (KCO4) resembles the electrical properties of a voltage-independent K+ channel after expression in Xenopus oocytes and yeast. Hyperpolarizing as well as depolarizing membrane voltages elicited instantaneous K+ currents, which were blocked by extracellular calcium and cytoplasmic protons. Functional complementation assays using a K+ transport-deficient yeast confirmed the biophysical and pharmacological properties of the AtTPK4 channel. The features of AtTPK4 point toward a role in potassium homeostasis and membrane voltage control of the growing pollen tube. Thus, AtTPK4 represents a member of plant tandem-pore-K+ channels, resembling the characteristics of its animal counterparts as well as plant-specific features with respect to modulation of channel activity by acidosis and calcium}, language = {en} } @article{MeinersPalmieriKlopfleischetal.2019, author = {Meiners, Jana and Palmieri, Vittoria and Klopfleisch, Robert and Ebel, Jana-Fabienne and Japtok, Lukasz and Schumacher, Fabian and Yusuf, Ayan Mohamud and Becker, Katrin Anne and Z{\"o}ller, Julia and Hose, Matthias and Kleuser, Burkhard and Hermann, Dirk Matthias and Kolesnick, Richard N. and Buer, Jan and Hansen, Wiebke and Westendorf, Astrid M.}, title = {Intestinal acid sphingomyelinase protects from severe Pathogen-Driven Colitis}, series = {Frontiers in immunology}, volume = {10}, journal = {Frontiers in immunology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-3224}, doi = {10.3389/fimmu.2019.01386}, pages = {14}, year = {2019}, abstract = {Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to contribute to its pathogenesis. In the present study, we determined the impact of acid sphingomyelinase (Asm), which catalyzes the hydrolysis of sphingomyelin to ceramide, on the course of Citrobacter (C.) rodentium-driven colitis. C. rodentium is an enteric pathogen and induces colonic inflammation very similar to the pathology in patients with ulcerative colitis. We found that mice with Asm deficiency or Asm inhibition were strongly susceptible to C. rodentium infection. These mice showed increased levels of C. rodentium in the feces and were prone to bacterial spreading to the systemic organs. In addition, mice lacking Asm activity showed an uncontrolled inflammatory T(h)1 and T(h)17 response, which was accompanied by a stronger colonic pathology compared to infected wild type mice. These findings identified Asm as an essential regulator of mucosal immunity to the enteric pathogen C. rodentium.}, language = {en} } @misc{TrilckeParrD'Aprileetal.2023, author = {Trilcke, Peer and Parr, Rolf and D'Aprile, Iwan-Michelangelo and Kraus, Hans-Christof and Blomqvist, Clarissa and McGillen, Petra S. and Aus der Au, Carmen and Phillips, Alexander Robert and Helmer, Debora and Singer, R{\"u}diger and G{\"o}rner, R{\"u}diger and Berbig, Roland and Rose, Dirk and Wilhelms, Kerstin and Krause, Marcus and Hehle, Christine and Gretz, Daniela and Gfrereis, Heike and Lepp, Nicola and Morlok, Franziska and Haut, Gideon and Brechenmacher, Thomas and Stauffer, Isabelle and Lyon, John B. and Bachmann, Vera and Ewert, Michael and Immer, Nikolas and Vedder, Ulrike and Fischer, Hubertus and Becker, Sabina and Wegmann, Christoph and M{\"o}ller, Klaus-Peter and Schneider, Ulrike and Waszynski, Alexander and Wedel, Michael and Brehm, David and Wolpert, Georg}, title = {Fontanes Medien}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Philosophische Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Philosophische Reihe}, number = {178}, editor = {Trilcke, Peer}, issn = {1866-8380}, doi = {10.25932/publishup-57407}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-574079}, pages = {XIII, 672}, year = {2023}, abstract = {Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische K{\"a}rrnerarbeit; er schrieb Kritiken {\"u}ber das Theater, die bildende Kunst und die Literatur - und auch seine Romane wie seine Reiseb{\"u}cher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen. Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen T{\"a}tigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, f{\"u}r die er sein Leben lang schrieb, und auf vielf{\"a}ltige Weise gepr{\"a}gt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie {\"a}sthetisch sensibler Grenzg{\"a}nger erkennbar.}, language = {de} } @inproceedings{TrilckeParrD'Aprileetal.2022, author = {Trilcke, Peer and Parr, Rolf and D'Aprile, Iwan-Michelangelo and Kraus, Hans-Christof and Blomqvist, Clarissa and McGillen, Petra S. and Aus der Au, Carmen and Phillips, Alexander Robert and Helmer, Debora and Singer, R{\"u}diger and G{\"o}rner, R{\"u}diger and Berbig, Roland and Rose, Dirk and Wilhelms, Kerstin and Krause, Marcus and Hehle, Christine and Gretz, Daniela and Gfrereis, Heike and Lepp, Nicola and Morlok, Franziska and Haut, Gideon and Brechenmacher, Thomas and Stauffer, Isabelle and Lyon, John B. and Bachmann, Vera and Ewert, Michael and Immer, Nikolas and Vedder, Ulrike and Fischer, Hubertus and Becker, Sabina and Wegmann, Christoph and M{\"o}ller, Klaus-Peter and Schneider, Ulrike and Waszynski, Alexander and Wedel, Michael and Brehm, David and Wolpert, Georg}, title = {Fontanes Medien}, editor = {Trilcke, Peer}, publisher = {De Gruyter}, address = {Berlin}, isbn = {978-3-11-073330-3}, doi = {10.1515/9783110733235}, pages = {XIII, 672}, year = {2022}, abstract = {Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische K{\"a}rrnerarbeit; er schrieb Kritiken {\"u}ber das Theater, die bildende Kunst und die Literatur - und auch seine Romane wie seine Reiseb{\"u}cher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen. Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen T{\"a}tigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, f{\"u}r die er sein Leben lang schrieb, und auf vielf{\"a}ltige Weise gepr{\"a}gt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie {\"a}sthetisch sensibler Grenzg{\"a}nger erkennbar.}, language = {de} } @misc{DahmBeckerBischoffetal.2013, author = {Dahm, Torsten and Becker, Dirk and Bischoff, Monika and Cesca, Simone and Dost, B. and Fritschen, R. and Hainzl, Sebastian and Klose, C. D. and Kuhn, D. and Lasocki, S. and Meier, Thomas and Ohrnberger, Matthias and Rivalta, Eleonora and Wegler, Ulrich and Husen, Stephan}, title = {Recommendation for the discrimination of human-related and natural seismicity}, series = {Journal of seismology}, volume = {17}, journal = {Journal of seismology}, number = {1}, publisher = {Springer}, address = {Dordrecht}, issn = {1383-4649}, doi = {10.1007/s10950-012-9295-6}, pages = {197 -- 202}, year = {2013}, abstract = {Various techniques are utilized by the seismological community, extractive industries, energy and geoengineering companies to identify earthquake nucleation processes in close proximity to engineering operation points. These operations may comprise fluid extraction or injections, artificial water reservoir impoundments, open pit and deep mining, deep geothermal power generations or carbon sequestration. In this letter to the editor, we outline several lines of investigation that we suggest to follow to address the discrimination problem between natural seismicity and seismic events induced or triggered by geoengineering activities. These suggestions have been developed by a group of experts during several meetings and workshops, and we feel that their publication as a summary report is helpful for the geoscientific community. Specific investigation procedures and discrimination approaches, on which our recommendations are based, are also published in this Special Issue (SI) of Journal of Seismology.}, language = {en} } @article{MaghsoudiCescaHainzletal.2013, author = {Maghsoudi, Samira and Cesca, Simone and Hainzl, Sebastian and Kaiser, Diethelm and Becker, Dirk and Dahm, Torsten}, title = {Improving the estimation of detection probability and magnitude of completeness in strongly heterogeneous media, an application to acoustic emission (AE)}, series = {Geophysical journal international}, volume = {193}, journal = {Geophysical journal international}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggt049}, pages = {1556 -- 1569}, year = {2013}, abstract = {Reliable estimations of magnitude of completeness (M-c) are essential for a correct interpretation of seismic catalogues. The spatial distribution of M-c may be strongly variable and difficult to assess in mining environments, owing to the presence of galleries, cavities, fractured regions, porous media and different mineralogical bodies, as well as in consequence of inhomogeneous spatial distribution of the seismicity. We apply a 3-D modification of the probabilistic magnitude of completeness (PMC) method, which relies on the analysis of network detection capabilities. In our approach, the probability to detect an event depends on its magnitude, source receiver Euclidian distance and source receiver direction. The suggested method is proposed for study of the spatial distribution of the magnitude of completeness in a mining environment and here is applied to a 2-months acoustic emission (AE) data set recorded at the Morsleben salt mine, Germany. The dense seismic network and the large data set, which includes more than one million events, enable a detailed testing of the method. This method is proposed specifically for strongly heterogeneous media. Besides, it can also be used for specific network installations, with sensors with a sensitivity, dependent on the direction of the incoming wave (e.g. some piezoelectric sensors). In absence of strong heterogeneities, the standards PMC approach should be used. We show that the PMC estimations in mines strongly depend on the source receiver direction, and cannot be correctly accounted using a standard PMC approach. However, results can be improved, when adopting the proposed 3-D modification of the PMC method. Our analysis of one central horizontal and vertical section yields a magnitude of completeness of about M-c approximate to 1 (AE magnitude) at the centre of the network, which increases up to M-c approximate to 4 at further distances outside the network; the best detection performance is estimated for a NNE-SSE elongated region, which corresponds to the strike direction of the low-attenuating salt body. Our approach provides us with small-scale details about the capability of sensors to detect an earthquake, which can be linked to the presence of heterogeneities in specific directions. Reduced detection performance in presence of strong structural heterogeneities (cavities) is confirmed by synthetic waveform modelling in heterogeneous media.}, language = {en} } @article{BrinkmannBeckerZimmermannetal.2022, author = {Brinkmann, Kai Oliver and Becker, Tim and Zimmermann, Florian and Kreusel, Cedric and Gahlmann, Tobias and Theisen, Manuel and Haeger, Tobias and Olthof, Selina and T{\"u}ckmantel, Christian and G{\"u}nster, M. and Maschwitz, Timo and G{\"o}belsmann, Fabian and Koch, Christine and Hertel, Dirk and Caprioglio, Pietro and Pe{\~n}a-Camargo, Francisco and Perdig{\´o}n-Toro, Lorena and Al-Ashouri, Amran and Merten, Lena and Hinderhofer, Alexander and Gomell, Leonie and Zhang, Siyuan and Schreiber, Frank and Albrecht, Steve and Meerholz, Klaus and Neher, Dieter and Stolterfoht, Martin and Riedl, Thomas}, title = {Perovskite-organic tandem solar cells with indium oxide interconnect}, series = {Nature}, volume = {604}, journal = {Nature}, number = {7905}, publisher = {Nature Research}, address = {Berlin}, issn = {0028-0836}, doi = {10.1038/s41586-022-04455-0}, pages = {280 -- 286}, year = {2022}, abstract = {Multijunction solar cells can overcome the fundamental efficiency limits of single-junction devices. The bandgap tunability of metal halide perovskite solar cells renders them attractive for multijunction architectures(1). Combinations with silicon and copper indium gallium selenide (CIGS), as well as all-perovskite tandem cells, have been reported(2-5). Meanwhile, narrow-gap non-fullerene acceptors have unlocked skyrocketing efficiencies for organic solar cells(6,7). Organic and perovskite semiconductors are an attractive combination, sharing similar processing technologies. Currently, perovskite-organic tandems show subpar efficiencies and are limited by the low open-circuit voltage (V-oc) of wide-gap perovskite cells(8) and losses introduced by the interconnect between the subcells(9,10). Here we demonstrate perovskite-organic tandem cells with an efficiency of 24.0 per cent (certified 23.1 per cent) and a high V-oc of 2.15 volts. Optimized charge extraction layers afford perovskite subcells with an outstanding combination of high V-oc and fill factor. The organic subcells provide a high external quantum efficiency in the near-infrared and, in contrast to paradigmatic concerns about limited photostability of non-fullerene cells(11), show an outstanding operational stability if excitons are predominantly generated on the non-fullerene acceptor, which is the case in our tandems. The subcells are connected by an ultrathin (approximately 1.5 nanometres) metal-like indium oxide layer with unprecedented low optical/electrical losses. This work sets a milestone for perovskite-organic tandems, which outperform the best p-i-n perovskite single junctions(12) and are on a par with perovskite-CIGS and all-perovskite multijunctions(13).}, language = {en} }