@techreport{BrodeurMikolaCooketal.2024,
type = {Working Paper},
author = {Brodeur, Abel and Mikola, Derek and Cook, Nikolai and Brailey, Thomas and Briggs, Ryan and Gendre, Alexandra de and Dupraz, Yannick and Fiala, Lenka and Gabani, Jacopo and Gauriot, Romain and Haddad, Joanne and Lima, Goncalo and Ankel-Peters, J{\"o}rg and Dreber, Anna and Campbell, Douglas and Kattan, Lamis and Fages, Diego Marino and Mierisch, Fabian and Sun, Pu and Wright, Taylor and Connolly, Marie and Hoces de la Guardia, Fernando and Johannesson, Magnus and Miguel, Edward and Vilhuber, Lars and Abarca, Alejandro and Acharya, Mahesh and Adjisse, Sossou Simplice and Akhtar, Ahwaz and Lizardi, Eduardo Alberto Ramirez and Albrecht, Sabina and Andersen, Synve Nygaard and Andlib, Zubaria and Arrora, Falak and Ash, Thomas and Bacher, Etienne and Bachler, Sebastian and Bacon, F{\´e}lix and Bagues, Manuel and Balogh, Timea and Batmanov, Alisher and Barschkett, Mara and Basdil, B. Kaan and Dower, Jaromneda and Castek, Ondrej and Caviglia-Harris, Jill and Strand, Gabriella Chauca and Chen, Shi and Chzhen, Asya and Chung, Jong and Collins, Jason and Coppock, Alexander and Cordeau, Hugo and Couillard, Ben and Crechet, Jonathan and Crippa, Lorenzo and Cui, Jeanne and Czymara, Christian and Daarstad, Haley and Dao, Danh Chi and Dao, Dong and Schmandt, Marco David and Linde, Astrid de and Melo, Lucas De and Deer, Lachlan and Vera, Micole De and Dimitrova, Velichka and Dollbaum, Jan Fabian and Dollbaum, Jan Matti and Donnelly, Michael and Huynh, Luu Duc Toan and Dumbalska, Tsvetomira and Duncan, Jamie and Duong, Kiet Tuan and Duprey, Thibaut and Dworschak, Christoph and Ellingsrud, Sigmund and Elminejad, Ali and Eissa, Yasmine and Erhart, Andrea and Etingin-Frati, Giulian and Fatemi-Pour, Elaheh and Federice, Alexa and Feld, Jan and Fenig, Guidon and Firouzjaeiangalougah, Mojtaba and Fleisje, Erlend and Fortier-Chouinard, Alexandre and Engel, Julia Francesca and Fries, Tilman and Fortier, Reid and Fr{\´e}chet, Nadjim and Galipeau, Thomas and Gallegos, Sebasti{\´a}n and Gangji, Areez and Gao, Xiaoying and Garnache, Clo{\´e} and G{\´a}sp{\´a}r, Attila and Gavrilova, Evelina and Ghosh, Arijit and Gibney, Garreth and Gibson, Grant and Godager, Geir and Goff, Leonard and Gong, Da and Gonz{\´a}lez, Javier and Gretton, Jeremy and Griffa, Cristina and Grigoryeva, Idaliya and Grtting, Maja and Guntermann, Eric and Guo, Jiaqi and Gugushvili, Alexi and Habibnia, Hooman and H{\"a}ffner, Sonja and Hall, Jonathan D. and Hammar, Olle and Kordt, Amund Hanson and Hashimoto, Barry and Hartley, Jonathan S. and Hausladen, Carina I. and Havr{\´a}nek, Tom{\´a}š and Hazen, Jacob and He, Harry and Hepplewhite, Matthew and Herrera-Rodriguez, Mario and Heuer, Felix and Heyes, Anthony and Ho, Anson T. Y. and Holmes, Jonathan and Holzknecht, Armando and Hsu, Yu-Hsiang Dexter and Hu, Shiang-Hung and Huang, Yu-Shiuan and Huebener, Mathias and Huber, Christoph and Huynh, Kim P. and Irsova, Zuzana and Isler, Ozan and Jakobsson, Niklas and Frith, Michael James and Jananji, Rapha{\"e}l and Jayalath, Tharaka A. and Jetter, Michael and John, Jenny and Forshaw, Rachel Joy and Juan, Felipe and Kadriu, Valon and Karim, Sunny and Kelly, Edmund and Dang, Duy Khanh Hoang and Khushboo, Tazia and Kim, Jin and Kjellsson, Gustav and Kjelsrud, Anders and Kotsadam, Andreas and Korpershoek, Jori and Krashinsky, Lewis and Kundu, Suranjana and Kustov, Alexander and Lalayev, Nurlan and Langlois, Audr{\´e}e and Laufer, Jill and Lee-Whiting, Blake and Leibing, Andreas and Lenz, Gabriel and Levin, Joel and Li, Peng and Li, Tongzhe and Lin, Yuchen and Listo, Ariel and Liu, Dan and Lu, Xuewen and Lukmanova, Elvina and Luscombe, Alex and Lusher, Lester R. and Lyu, Ke and Ma, Hai and M{\"a}der, Nicolas and Makate, Clifton and Malmberg, Alice and Maitra, Adit and Mandas, Marco and Marcus, Jan and Margaryan, Shushanik and M{\´a}rk, Lili and Martignano, Andres and Marsh, Abigail and Masetto, Isabella and McCanny, Anthony and McManus, Emma and McWay, Ryan and Metson, Lennard and Kinge, Jonas Minet and Mishra, Sumit and Mohnen, Myra and M{\"o}ller, Jakob and Montambeault, Rosalie and Montpetit, S{\´e}bastien and Morin, Louis-Philippe and Morris, Todd and Moser, Scott and Motoki, Fabio and Muehlenbachs, Lucija and Musulan, Andreea and Musumeci, Marco and Nabin, Munirul and Nchare, Karim and Neubauer, Florian and Nguyen, Quan M. P. and Nguyen, Tuan and Nguyen-Tien, Viet and Niazi, Ali and Nikolaishvili, Giorgi and Nordstrom, Ardyn and N{\"u}, Patrick and Odermatt, Angela and Olson, Matt and ien, Henning and {\"O}lkers, Tim and Vert, Miquel Oliver i. and Oral, Emre and Oswald, Christian and Ousman, Ali and {\"O}zak, {\"O}mer and Pandey, Shubham and Pavlov, Alexandre and Pelli, Martino and Penheiro, Romeo and Park, RyuGyung and Martel, Eva P{\´e}rez and Petrovičov{\´a}, Tereza and Phan, Linh and Prettyman, Alexa and Proch{\´a}zka, Jakub and Putri, Aqila and Quandt, Julian and Qiu, Kangyu and Nguyen, Loan Quynh Thi and Rahman, Andaleeb and Rea, Carson H. and Reiremo, Adam and Ren{\´e}e, La{\"e}titia and Richardson, Joseph and Rivers, Nicholas and Rodrigues, Bruno and Roelofs, William and Roemer, Tobias and Rogeberg, Ole and Rose, Julian and Roskos-Ewoldsen, Andrew and Rosmer, Paul and Sabada, Barbara and Saberian, Soodeh and Salamanca, Nicolas and Sator, Georg and Sawyer, Antoine and Scates, Daniel and Schl{\"u}ter, Elmar and Sells, Cameron and Sen, Sharmi and Sethi, Ritika and Shcherbiak, Anna and Sogaolu, Moyosore and Soosalu, Matt and Srensen, Erik and Sovani, Manali and Spencer, Noah and Staubli, Stefan and Stans, Renske and Stewart, Anya and Stips, Felix and Stockley, Kieran and Strobel, Stephenson and Struby, Ethan and Tang, John and Tanrisever, Idil and Yang, Thomas Tao and Tastan, Ipek and Tatić, Dejan and Tatlow, Benjamin and Seuyong, F{\´e}raud Tchuisseu and Th{\´e}riault, R{\´e}mi and Thivierge, Vincent and Tian, Wenjie and Toma, Filip-Mihai and Totarelli, Maddalena and Tran, Van-Anh and Truong, Hung and Tsoy, Nikita and Tuzcuoglu, Kerem and Ubfal, Diego and Villalobos, Laura and Walterskirchen, Julian and Wang, Joseph Taoyi and Wattal, Vasudha and Webb, Matthew D. and Weber, Bryan and Weisser, Reinhard and Weng, Wei-Chien and Westheide, Christian and White, Kimberly and Winter, Jacob and Wochner, Timo and Woerman, Matt and Wong, Jared and Woodard, Ritchie and Wroński, Marcin and Yazbeck, Myra and Yang, Gustav Chung and Yap, Luther and Yassin, Kareman and Ye, Hao and Yoon, Jin Young and Yurris, Chris and Zahra, Tahreen and Zaneva, Mirela and Zayat, Aline and Zhang, Jonathan and Zhao, Ziwei and Yaolang, Zhong},
title = {Mass reproducibility and replicability},
series = {I4R discussion paper series},
journal = {I4R discussion paper series},
number = {107},
publisher = {Institute for Replication},
address = {Essen},
issn = {2752-1931},
pages = {250},
year = {2024},
abstract = {This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85\%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25\% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70\%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52\% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77\% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes.},
language = {en}
}
@misc{MaierWolfKeiligetal.2018,
author = {Maier, Philipp and Wolf, J{\"u}rgen and Keilig, Thomas and Krabbe, Alfred and Duffard, Rene and Ortiz, Jose-Luis and Klinkner, Sabine and Lengowski, Michael and M{\"u}ller, Thomas and Lockowandt, Christian and Krockstedt, Christian and Kappelmann, Norbert and Stelzer, Beate and Werner, Klaus and Geier, Stephan and Kalkuhl, Christoph and Rauch, Thomas and Schanz, Thomas and Barnstedt, J{\"u}rgen and Conti, Lauro and Hanke, Lars},
title = {Towards a European Stratospheric Balloon Observatory},
series = {Ground-based and Airborne Telescopes VII},
volume = {10700},
journal = {Ground-based and Airborne Telescopes VII},
publisher = {SPIE-INT Soc Optical Engineering},
address = {Bellingham},
isbn = {978-1-5106-1954-8},
issn = {0277-786X},
doi = {10.1117/12.2319248},
pages = {12},
year = {2018},
abstract = {This paper presents the concept of a community-accessible stratospheric balloon-based observatory that is currently under preparation by a consortium of European research institutes and industry. We present the technical motivation, science case, instrumentation, and a two-stage image stabilization approach of the 0.5-m UV/visible platform. In addition, we briefly describe the novel mid-sized stabilized balloon gondola under design to carry telescopes in the 0.5 to 0.6 m range as well as the currently considered flight option for this platform. Secondly, we outline the scientific and technical motivation for a large balloon-based FIR telescope and the ESBO DS approach towards such an infrastructure.},
language = {en}
}
@article{WuttkeLiLietal.2019,
author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian},
title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals},
series = {Nature genetics},
volume = {51},
journal = {Nature genetics},
number = {6},
publisher = {Nature Publ. Group},
address = {New York},
organization = {Lifelines COHort Study},
issn = {1061-4036},
doi = {10.1038/s41588-019-0407-x},
pages = {957 -- +},
year = {2019},
abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.},
language = {en}
}
@misc{GorskiJungLietal.2020,
author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.},
title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline},
series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t},
journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t},
number = {19},
doi = {10.25932/publishup-56537},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565379},
pages = {14},
year = {2020},
abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.},
language = {en}
}
@article{GorskiJungLietal.2020,
author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.},
title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline},
series = {Kidney international : official journal of the International Society of Nephrology},
volume = {99},
journal = {Kidney international : official journal of the International Society of Nephrology},
number = {4},
publisher = {Elsevier},
address = {New York},
organization = {Lifelines Cohort Study
Regeneron Genetics Ctr},
issn = {0085-2538},
doi = {10.1016/j.kint.2020.09.030},
pages = {926 -- 939},
year = {2020},
abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.},
language = {en}
}
@article{KaaSternemannAppeletal.2022,
author = {Kaa, Johannes M. and Sternemann, Christian and Appel, Karen and Cerantola, Valerio and Preston, Thomas R. and Albers, Christian and Elbers, Mirko and Libon, Lelia and Makita, Mikako and Pelka, Alexander and Petitgirard, Sylvain and Pl{\"u}ckthun, Christian and Roddatis, Vladimir and Sahle, Christoph J. and Spiekermann, Georg and Schmidt, Christian and Schreiber, Anja and Sakrowski, Robin and Tolan, Metin and Wilke, Max and Zastrau, Ulf and Konopkova, Zuzana},
title = {Structural and electron spin state changes in an x-ray heated iron carbonate system at the Earth's lower mantle pressures},
series = {Physical review research},
volume = {4},
journal = {Physical review research},
number = {3},
publisher = {American Physical Society},
address = {College Park},
issn = {2643-1564},
doi = {10.1103/PhysRevResearch.4.033042},
pages = {9},
year = {2022},
abstract = {The determination of the spin state of iron-bearing compounds at high pressure and temperature is crucial for our understanding of chemical and physical properties of the deep Earth. Studies on the relationship between the coordination of iron and its electronic spin structure in iron-bearing oxides, silicates, carbonates, iron alloys, and other minerals found in the Earth's mantle and core are scarce because of the technical challenges to simultaneously probe the sample at high pressures and temperatures. We used the unique properties of a pulsed and highly brilliant x-ray free electron laser (XFEL) beam at the High Energy Density (HED) instrument of the European XFEL to x-ray heat and probe samples contained in a diamond anvil cell. We heated and probed with the same x-ray pulse train and simultaneously measured x-ray emission and x-ray diffraction of an FeCO3 sample at a pressure of 51 GPa with up to melting temperatures. We collected spin state sensitive Fe K beta(1,3) fluorescence spectra and detected the sample's structural changes via diffraction, observing the inverse volume collapse across the spin transition. During x-ray heating, the carbonate transforms into orthorhombic Fe4C3O12 and iron oxides. Incipient melting was also observed. This approach to collect information about the electronic state and structural changes from samples contained in a diamond anvil cell at melting temperatures and above will considerably improve our understanding of the structure and dynamics of planetary and exoplanetary interiors.},
language = {en}
}
@misc{HetenyiMolinariClintonetal.2018,
author = {Hetenyi, Gyorgy and Molinari, Irene and Clinton, John and Bokelmann, Gotz and Bondar, Istvan and Crawford, Wayne C. and Dessa, Jean-Xavier and Doubre, Cecile and Friederich, Wolfgang and Fuchs, Florian and Giardini, Domenico and Graczer, Zoltan and Handy, Mark R. and Herak, Marijan and Jia, Yan and Kissling, Edi and Kopp, Heidrun and Korn, Michael and Margheriti, Lucia and Meier, Thomas and Mucciarelli, Marco and Paul, Anne and Pesaresi, Damiano and Piromallo, Claudia and Plenefisch, Thomas and Plomerova, Jaroslava and Ritter, Joachim and Rumpker, Georg and Sipka, Vesna and Spallarossa, Daniele and Thomas, Christine and Tilmann, Frederik and Wassermann, Joachim and Weber, Michael and Weber, Zoltan and Wesztergom, Viktor and Zivcic, Mladen and Abreu, Rafael and Allegretti, Ivo and Apoloner, Maria-Theresia and Aubert, Coralie and Besancon, Simon and de Berc, Maxime Bes and Brunel, Didier and Capello, Marco and Carman, Martina and Cavaliere, Adriano and Cheze, Jerome and Chiarabba, Claudio and Cougoulat, Glenn and Cristiano, Luigia and Czifra, Tibor and Danesi, Stefania and Daniel, Romuald and Dannowski, Anke and Dasovic, Iva and Deschamps, Anne and Egdorf, Sven and Fiket, Tomislav and Fischer, Kasper and Funke, Sigward and Govoni, Aladino and Groschl, Gidera and Heimers, Stefan and Heit, Ben and Herak, Davorka and Huber, Johann and Jaric, Dejan and Jedlicka, Petr and Jund, Helene and Klingen, Stefan and Klotz, Bernhard and Kolinsky, Petr and Kotek, Josef and Kuhne, Lothar and Kuk, Kreso and Lange, Dietrich and Loos, Jurgen and Lovati, Sara and Malengros, Deny and Maron, Christophe and Martin, Xavier and Massa, Marco and Mazzarini, Francesco and Metral, Laurent and Moretti, Milena and Munzarova, Helena and Nardi, Anna and Pahor, Jurij and Pequegnat, Catherine and Petersen, Florian and Piccinini, Davide and Pondrelli, Silvia and Prevolnik, Snjezan and Racine, Roman and Regnier, Marc and Reiss, Miriam and Salimbeni, Simone and Santulin, Marco and Scherer, Werner and Schippkus, Sven and Schulte-Kortnack, Detlef and Solarino, Stefano and Spieker, Kathrin and Stipcevic, Josip and Strollo, Angelo and Sule, Balint and Szanyi, Gyongyver and Szucs, Eszter and Thorwart, Martin and Ueding, Stefan and Vallocchia, Massimiliano and Vecsey, Ludek and Voigt, Rene and Weidle, Christian and Weyland, Gauthier and Wiemer, Stefan and Wolf, Felix and Wolyniec, David and Zieke, Thomas},
title = {The AlpArray seismic network},
series = {Surveys in Geophysics},
volume = {39},
journal = {Surveys in Geophysics},
number = {5},
publisher = {Springer},
address = {Dordrecht},
organization = {ETHZ SED Elect Lab AlpArray Seismic Network Team AlpArray OBS Cruise Crew AlpArray Working Grp},
issn = {0169-3298},
doi = {10.1007/s10712-018-9472-4},
pages = {1009 -- 1033},
year = {2018},
abstract = {The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.},
language = {en}
}
@article{AnklamBehlerDingermannetal.2013,
author = {Anklam, Elke and Behler, J{\"o}rg and Dingermann, Theodor and Elsinghorst, Paul and Fischer, Jochen and Esselen, Melanie and Foerster, Christian and Fr{\"o}hlich, Daniel and Goedel, Werner Andreas and Gregory, Peter and Grimme, Stefan and Hackenberger, Christian and Hansmann, Max and Heppekausen, Johannes and Hasenstab-Riedel, Sebastian and Kirchhoff, Erhard and Kratz, Karl-Ludwig and Krausz, Ferenc and Linker, Torsten and List, Benjamin and Ray, Kallol and Salzer, Reiner and Schubert, Ulrich and Schueth, Ferdi and Schwarz, Helmut and Schwietzke, Uta and Strey, Reinhard and Stumpf, Thorsten and Vaagt, Franziska and Volodkin, Dmitry and Wilke, Guenther and Zass, Engelbert and Zemb, Thomas},
title = {Awards},
series = {Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker},
volume = {61},
journal = {Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker},
number = {11},
publisher = {Ges. Dt. Chemiker},
address = {Frankfurt, Main},
issn = {1439-9598},
doi = {10.1002/nadc.201390372},
pages = {1145 -- 1148},
year = {2013},
language = {de}
}
@misc{ArnisonBibbBierbaumetal.2013,
author = {Arnison, Paul G. and Bibb, Mervyn J. and Bierbaum, Gabriele and Bowers, Albert A. and Bugni, Tim S. and Bulaj, Grzegorz and Camarero, Julio A. and Campopiano, Dominic J. and Challis, Gregory L. and Clardy, Jon and Cotter, Paul D. and Craik, David J. and Dawson, Michael and Dittmann-Th{\"u}nemann, Elke and Donadio, Stefano and Dorrestein, Pieter C. and Entian, Karl-Dieter and Fischbach, Michael A. and Garavelli, John S. and Goeransson, Ulf and Gruber, Christian W. and Haft, Daniel H. and Hemscheidt, Thomas K. and Hertweck, Christian and Hill, Colin and Horswill, Alexander R. and Jaspars, Marcel and Kelly, Wendy L. and Klinman, Judith P. and Kuipers, Oscar P. and Link, A. James and Liu, Wen and Marahiel, Mohamed A. and Mitchell, Douglas A. and Moll, Gert N. and Moore, Bradley S. and Mueller, Rolf and Nair, Satish K. and Nes, Ingolf F. and Norris, Gillian E. and Olivera, Baldomero M. and Onaka, Hiroyasu and Patchett, Mark L. and Piel, J{\"o}rn and Reaney, Martin J. T. and Rebuffat, Sylvie and Ross, R. Paul and Sahl, Hans-Georg and Schmidt, Eric W. and Selsted, Michael E. and Severinov, Konstantin and Shen, Ben and Sivonen, Kaarina and Smith, Leif and Stein, Torsten and Suessmuth, Roderich D. and Tagg, John R. and Tang, Gong-Li and Truman, Andrew W. and Vederas, John C. and Walsh, Christopher T. and Walton, Jonathan D. and Wenzel, Silke C. and Willey, Joanne M. and van der Donk, Wilfred A.},
title = {Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature},
series = {Natural product reports : a journal of current developments in bio-organic chemistry},
volume = {30},
journal = {Natural product reports : a journal of current developments in bio-organic chemistry},
number = {1},
publisher = {Royal Society of Chemistry},
address = {Cambridge},
issn = {0265-0568},
doi = {10.1039/c2np20085f},
pages = {108 -- 160},
year = {2013},
abstract = {This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.},
language = {en}
}
@article{DenglerWagnerDembiczetal.2018,
author = {Dengler, J{\"u}rgen and Wagner, Viktoria and Dembicz, Iwona and Garcia-Mijangos, Itziar and Naqinezhad, Alireza and Boch, Steffen and Chiarucci, Alessandro and Conradi, Timo and Filibeck, Goffredo and Guarino, Riccardo and Janisova, Monika and Steinbauer, Manuel J. and Acic, Svetlana and Acosta, Alicia T. R. and Akasaka, Munemitsu and Allers, Marc-Andre and Apostolova, Iva and Axmanova, Irena and Bakan, Branko and Baranova, Alina and Bardy-Durchhalter, Manfred and Bartha, Sandor and Baumann, Esther and Becker, Thomas and Becker, Ute and Belonovskaya, Elena and Bengtsson, Karin and Benito Alonso, Jose Luis and Berastegi, Asun and Bergamini, Ariel and Bonini, Ilaria and Bruun, Hans Henrik and Budzhak, Vasyl and Bueno, Alvaro and Antonio Campos, Juan and Cancellieri, Laura and Carboni, Marta and Chocarro, Cristina and Conti, Luisa and Czarniecka-Wiera, Marta and De Frenne, Pieter and Deak, Balazs and Didukh, Yakiv P. and Diekmann, Martin and Dolnik, Christian and Dupre, Cecilia and Ecker, Klaus and Ermakov, Nikolai and Erschbamer, Brigitta and Escudero, Adrian and Etayo, Javier and Fajmonova, Zuzana and Felde, Vivian A. and Fernandez Calzado, Maria Rosa and Finckh, Manfred and Fotiadis, Georgios and Fracchiolla, Mariano and Ganeva, Anna and Garcia-Magro, Daniel and Gavilan, Rosario G. and Germany, Markus and Giladi, Itamar and Gillet, Francois and Giusso del Galdo, Gian Pietro and Gonzalez, Jose M. and Grytnes, John-Arvid and Hajek, Michal and Hajkova, Petra and Helm, Aveliina and Herrera, Mercedes and Hettenbergerova, Eva and Hobohm, Carsten and Huellbusch, Elisabeth M. and Ingerpuu, Nele and Jandt, Ute and Jeltsch, Florian and Jensen, Kai and Jentsch, Anke and Jeschke, Michael and Jimenez-Alfaro, Borja and Kacki, Zygmunt and Kakinuma, Kaoru and Kapfer, Jutta and Kavgaci, Ali and Kelemen, Andras and Kiehl, Kathrin and Koyama, Asuka and Koyanagi, Tomoyo F. and Kozub, Lukasz and Kuzemko, Anna and Kyrkjeeide, Magni Olsen and Landi, Sara and Langer, Nancy and Lastrucci, Lorenzo and Lazzaro, Lorenzo and Lelli, Chiara and Leps, Jan and Loebel, Swantje and Luzuriaga, Arantzazu L. and Maccherini, Simona and Magnes, Martin and Malicki, Marek and Marceno, Corrado and Mardari, Constantin and Mauchamp, Leslie and May, Felix and Michelsen, Ottar and Mesa, Joaquin Molero and Molnar, Zsolt and Moysiyenko, Ivan Y. and Nakaga, Yuko K. and Natcheva, Rayna and Noroozi, Jalil and Pakeman, Robin J. and Palpurina, Salza and Partel, Meelis and Paetsch, Ricarda and Pauli, Harald and Pedashenko, Hristo and Peet, Robert K. and Pielech, Remigiusz and Pipenbaher, Natasa and Pirini, Chrisoula and Pleskova, Zuzana and Polyakova, Mariya A. and Prentice, Honor C. and Reinecke, Jennifer and Reitalu, Triin and Pilar Rodriguez-Rojo, Maria and Rolecek, Jan and Ronkin, Vladimir and Rosati, Leonardo and Rosen, Ejvind and Ruprecht, Eszter and Rusina, Solvita and Sabovljevic, Marko and Maria Sanchez, Ana and Savchenko, Galina and Schuhmacher, Oliver and Skornik, Sonja and Sperandii, Marta Gaia and Staniaszek-Kik, Monika and Stevanovic-Dajic, Zora and Stock, Marin and Suchrow, Sigrid and Sutcliffe, Laura M. E. and Swacha, Grzegorz and Sykes, Martin and Szabo, Anna and Talebi, Amir and Tanase, Catalin and Terzi, Massimo and Tolgyesi, Csaba and Torca, Marta and Torok, Peter and Tothmeresz, Bela and Tsarevskaya, Nadezda and Tsiripidis, Ioannis and Tzonev, Rossen and Ushimaru, Atushi and Valko, Orsolya and van der Maarel, Eddy and Vanneste, Thomas and Vashenyak, Iuliia and Vassilev, Kiril and Viciani, Daniele and Villar, Luis and Virtanen, Risto and Kosic, Ivana Vitasovic and Wang, Yun and Weiser, Frank and Went, Julia and Wesche, Karsten and White, Hannah and Winkler, Manuela and Zaniewski, Piotr T. and Zhang, Hui and Ziv, Yaron and Znamenskiy, Sergey and Biurrun, Idoia},
title = {GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands},
series = {Phytocoenologia},
volume = {48},
journal = {Phytocoenologia},
number = {3},
publisher = {Cramer},
address = {Stuttgart},
issn = {0340-269X},
doi = {10.1127/phyto/2018/0267},
pages = {331 -- 347},
year = {2018},
abstract = {GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.},
language = {en}
}
@article{GehringDorschDoerfler2019,
author = {Gehring, Thomas and Dorsch, Christian and D{\"o}rfler, Thomas},
title = {Precedent and doctrine in organisational decision-making},
series = {Journal of international relations and development},
volume = {22},
journal = {Journal of international relations and development},
number = {1},
publisher = {Palgrave Macmillan},
address = {Basingstoke},
issn = {1581-1980},
doi = {10.1057/s41268-017-0101-5},
pages = {107 -- 135},
year = {2019},
abstract = {We examine how and under what conditions informal institutional constraints, such as precedent and doctrine, are likely to affect collective choice within international organisations even in the absence of powerful bureaucratic agents. With a particular focus on the United Nations Security Council, we first develop a theoretical account of why such informal constraints might affect collective decisions even of powerful and strategically behaving actors. We show that precedents provide focal points that allow adopting collective decisions in coordination situations despite diverging preferences. Reliance on previous cases creates tacitly evolving doctrine that may develop incrementally. Council decision-making is also likely to be facilitated by an institutional logic of escalation driven by institutional constraints following from the typically staged response to crisis situations. We explore the usefulness of our theoretical argument with evidence from the Council doctrine on terrorism that has evolved since 1985. The key decisions studied include the 1992 sanctions resolution against Libya and the 2001 Council response to the 9/11 attacks. We conclude that, even within intergovernmentally structured international organisations, member states do not operate on a clean slate, but in a highly institutionalised environment that shapes their opportunities for action.},
language = {en}
}
@article{SvenningGravelHoltetal.2014,
author = {Svenning, Jens-Christian and Gravel, Dominique and Holt, Robert D. and Schurr, Frank Martin and Thuiller, Wilfried and Muenkemueller, Tamara and Schiffers, Katja H. and Dullinger, Stefan and Edwards, Thomas C. and Hickler, Thomas and Higgins, Steven I. and Nabel, Julia E. M. S. and Pagel, J{\"o}rn and Normand, Signe},
title = {The influence of interspecific interactions on species range expansion rates},
series = {Ecography : pattern and diversity in ecology ; research papers forum},
volume = {37},
journal = {Ecography : pattern and diversity in ecology ; research papers forum},
number = {12},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {0906-7590},
doi = {10.1111/j.1600-0587.2013.00574.x},
pages = {1198 -- 1209},
year = {2014},
language = {en}
}
@misc{TaubertBalischewskiHentrichetal.2017,
author = {Taubert, Andreas and Balischewski, Christian and Hentrich, Doreen and Elschner, Thomas and Eidner, Sascha and G{\"u}nter, Christina and Behrens, Karsten and Heinze, Thomas},
title = {Water-soluble cellulose derivatives are sustainable additives for biomimetic calcium phosphate mineralization},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-400453},
pages = {17},
year = {2017},
abstract = {The effect of cellulose-based polyelectrolytes on biomimetic calcium phosphate mineralization is described. Three cellulose derivatives, a polyanion, a polycation, and a polyzwitterion were used as additives. Scanning electron microscopy, X-ray diffraction, IR and Raman spectroscopy show that, depending on the composition of the starting solution, hydroxyapatite or brushite precipitates form. Infrared and Raman spectroscopy also show that significant amounts of nitrate ions are incorporated in the precipitates. Energy dispersive X-ray spectroscopy shows that the Ca/P ratio varies throughout the samples and resembles that of other bioinspired calcium phosphate hybrid materials. Elemental analysis shows that the carbon (i.e., polymer) contents reach 10\% in some samples, clearly illustrating the formation of a true hybrid material. Overall, the data indicate that a higher polymer concentration in the reaction mixture favors the formation of polymer-enriched materials, while lower polymer concentrations or high precursor concentrations favor the formation of products that are closely related to the control samples precipitated in the absence of polymer. The results thus highlight the potential of (water-soluble) cellulose derivatives for the synthesis and design of bioinspired and bio-based hybrid materials.},
language = {en}
}
@article{TaubertBalischewskiHentrichetal.2016,
author = {Taubert, Andreas and Balischewski, Christian and Hentrich, Doreen and Elschner, Thomas and Eidner, Sascha and G{\"u}nter, Christina and Behrens, Karsten and Heinze, Thomas},
title = {Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization},
series = {Inorganics : open access journal},
volume = {4},
journal = {Inorganics : open access journal},
publisher = {MDPI},
address = {Basel},
issn = {2304-6740},
doi = {10.3390/inorganics4040033},
pages = {17},
year = {2016},
abstract = {The effect of cellulose-based polyelectrolytes on biomimetic calcium phosphate mineralization is described. Three cellulose derivatives, a polyanion, a polycation, and a polyzwitterion were used as additives. Scanning electron microscopy, X-ray diffraction, IR and Raman spectroscopy show that, depending on the composition of the starting solution, hydroxyapatite or brushite precipitates form. Infrared and Raman spectroscopy also show that significant amounts of nitrate ions are incorporated in the precipitates. Energy dispersive X-ray spectroscopy shows that the Ca/P ratio varies throughout the samples and resembles that of other bioinspired calcium phosphate hybrid materials. Elemental analysis shows that the carbon (i.e., polymer) contents reach 10\% in some samples, clearly illustrating the formation of a true hybrid material. Overall, the data indicate that a higher polymer concentration in the reaction mixture favors the formation of polymer-enriched materials, while lower polymer concentrations or high precursor concentrations favor the formation of products that are closely related to the control samples precipitated in the absence of polymer. The results thus highlight the potential of (water-soluble) cellulose derivatives for the synthesis and design of bioinspired and bio-based hybrid materials.},
language = {en}
}
@book{EbkeZanfiKruegeretal.2017,
author = {Ebke, Thomas and Zanfi, Caterina and Kr{\"u}ger, Hans-Peter and Sommer, Christian and Viennet, Thomas and Johannßen, Dennis and Balzaretti, Ugo and Toussaint Ondoua, Herv{\´e} and Agard, Olivier and Henckmann, Wolfhart and Simonotti, Edoardo and Hand, Annika and Tavakkoli, Amirpasha and Hackbarth, Daniel and Edinger, Sebastian and Schollmeyer, Justus and von Kalckreuth, Moritz Alexander and Schmieg, Gregor and Batista Rates, Bruno and Kressmann, Philipp and Hilt, Annette and van Buuren, Jasper and Keusch, Juliane and Guzun, Mădălina and Bruff, Kyla and Stahl, Marion and Held, Lukas},
title = {Das Leben im Menschen oder der Mensch im Leben?},
editor = {Ebke, Thomas and Zanfi, Caterina},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
isbn = {978-3-86956-382-4},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-95409},
publisher = {Universit{\"a}t Potsdam},
pages = {514 Seiten},
year = {2017},
abstract = {In der Philosophie des 20. Jahrhunderts wird deutlich, dass es in Frankreich und in Deutschland voneinander abweichende Sichtweisen auf die Frage gibt, ob der Mensch eine "Sonderstellung" in der Dynamik des biologischen und geschichtlichen Lebens genießt. W{\"a}hrend sich in Deutschland die Tradition eines anthropologischen Denkens neu formiert, ist in Frankreich eine scharfe Skepsis gegen{\"u}ber dem Erbe des Humanismus charakteristisch. Die Beitr{\"a}ge dieses zweisprachigen Buches untersuchen diese deutsch-franz{\"o}sische Konstellation von Fragen und Autoren, und aktualisieren die Reflexion auf die (Grenzen der) Singularit{\"a}t des Menschen.},
language = {de}
}
@article{MiegelGraeffSelleetal.2016,
author = {Miegel, Konrad and Graeff, Thomas and Selle, Benny and Salzmann, Thomas and Franck, Christian and Bronstert, Axel},
title = {Investigation of a renatured fen on the Baltic Sea coast of Mecklenburg - Part I: System description and basic hydrological characterisation},
series = {Hydrologie und Wasserbewirtschaftung},
volume = {60},
journal = {Hydrologie und Wasserbewirtschaftung},
publisher = {Bundesanst. f{\~A}¼r Gew{\~A}\isserkunde},
address = {Koblenz},
issn = {1439-1783},
doi = {10.5675/HyWa_2016.4_1},
pages = {242 -- 258},
year = {2016},
language = {de}
}
@article{MiegelGraeffFrancketal.2017,
author = {Miegel, Konrad and Gr{\"a}ff, Thomas and Franck, Christian and Salzmann, Thomas and Bronstert, Axel and Walther, Marc and Oswald, Sascha},
title = {Auswirkungen des Sturmhochwassers der Ostsee am 4./5. Januar 2017 auf das renaturierte Nieder- moor „H{\"u}telmoor und Heiligensee" an der deut- schen Ostseek{\"u}ste},
series = {Hydrologie und Wasserbewirtschaftung},
volume = {61},
journal = {Hydrologie und Wasserbewirtschaftung},
number = {4},
publisher = {Bundesanst. f{\"u}r Gew{\"a}sserkunde},
address = {Koblenz},
issn = {1439-1783},
doi = {10.5675/HyWa_2017,4_2},
pages = {232 -- 243},
year = {2017},
abstract = {Entlang der K{\"u}stenniederung des Naturschutzgebietes „H{\"u}telmoor und Heiligensee", ca. 6 km nord{\"o}stlich von Rostock-Warnem{\"u}nde gelegen, wird seit dem Jahr 2000 die K{\"u}stend{\"u}ne nicht mehr instand gehalten. Im Rahmen der Renaturierung des Gebietes werden so grunds{\"a}tzlich wieder {\"U}berflutungen bei Ostseehochwassern zugelassen, was bisher jedoch noch nicht eingetreten ist. Am 4./5. Januar 2017 ereignete sich ein Sturmhochwasser der Ostsee, mit einem Scheitelwasserstand in Warnem{\"u}nde, der sich zwischen dem 10- und 20-j{\"a}hrlichen Hochwasserstand einordnet. Dennoch kam es bei diesem Ereignis nicht zum D{\"u}nendurchbruch und zur seeseitigen {\"U}berflutung, wohl aber zum binnenseitigen Einstrom von Salz- bzw. Brackwasser. Dieser erfolgte {\"u}ber den Graben, durch den das Gebiet normalerweise {\"u}ber die Warnow in die Ostsee entw{\"a}ssert. Durch das Einstr{\"o}men {\"u}ber die Sohlschwelle, sonst Auslass des Gebietes, stiegen die Wasserst{\"a}nde und Salzkonzentrationen in der s{\"u}dwestlichen H{\"a}lfte der Niederung an. Mit zunehmender Entfernung zur Sohlschwelle waren diese Auswirkungen jedoch geringer sp{\"u}rbar. Dies gilt wegen der Retentionswirkung der Niederung mehr f{\"u}r den Wasserstand als f{\"u}r die Salzkonzentration. W{\"a}hrend der Wasserstand durch den Einstau der Niederung und {\"U}berschwemmungen fl{\"a}chenhaft anstieg, breitete sich die Salzfront pr{\"a}ferentiell in den ehemaligen Entw{\"a}sserungsgr{\"a}ben, die trotz des Einstaus nach wie vor hydraulisch aktiv sind, eher linienhaft aus. Diese Interpretation beruht auf Messergebnissen von Wasserstand, elektrischer Leitf{\"a}higkeit und Wassertemperatur.},
language = {de}
}
@article{AbdallaAbramowskiAharonianetal.2016,
author = {Abdalla, Hassan E. and Abramowski, Attila and Aharonian, Felix A. and Benkhali, Fai{\c{c}}al Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Arrieta, M. and Aubert, Pierre and Backes, Michael and Balzer, Arnim and Barnard, Michelle and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, K. and Birsin, E. and Blackwell, R. and Bottcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Capasso, M. and Carr, John and Casanova, Sabrina and Chakraborty, N. and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chen, Andrew and Chevalier, J. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Condon, B. and Conrad, Jan and Couturier, C. and Cui, Y. and Davids, I. D. and Degrange, B. and Deil, Christoph and deWilt, P. and Djannati-Atai, Arache and Domainko, Wilfried and Donath, Axel and Dubus, Guillaume and Dutson, Kate and Dyks, J. and Dyrda, M. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, Stuart and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Foerster, A. and Funk, S. and F{\"u}ßling, Matthias and Gabici, Stefano and Gajdus, M. and Gallant, Y. A. and Garrigoux, T. and Giavitto, Gianluca and Giebels, B. and Glicenstein, J. F. and Gottschall, Daniel and Goyal, A. and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Hahn, J. and Hawkes, J. and Heinzelmann, G. and Henri, Gilles and Hermann, G. and Hervet, Olivier and Hillert, A. and Hinton, James Anthony and Hofmann, Werner and Hoischen, Clemens and Holler, M. and Horns, D. and Ivascenko, Alex and Jacholkowska, A. and Jamrozy, Marek and Janiak, M. and Jankowsky, D. and Jankowsky, Felix and Jingo, M. and Jogler, Tobias and Jouvin, Lea and Jung-Richardt, Ira and Kastendieck, M. A. and Katarzynski, Krzysztof and Katz, Uli and Kerszberg, D. and Khelifi, B. and Kieffer, M. and King, J. and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, Michael and Krayzel, F. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, Jeanie and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, Thomas and Lorentz, M. and Lui, R. and Lypova, Iryna and Marandon, Vincent and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, Michael and Meintjes, Petrus Johannes and Menzler, U. and Meyer, Manuel and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, T. and de Naurois, Mathieu and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, Hirokazu and Ohm, Stefan and Oettl, S. and Ostrowski, M. and Oya, I. and Padovani, Marco and Panter, M. and Parsons, R. D. and Arribas, M. Paz and Pekeur, N. W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and Prokhorov, Dmitry and Prokoph, Heike and Puehlhofer, Gerd and Punch, Michael and Quirrenbach, Andreas and Raab, S. and Reimer, Anita and Reimer, Olaf and Renaud, M. and de los Reyes, R. and Rieger, Frank and Romoli, Carlo and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Salek, David and Sanchez, David A. and Santangelo, Andrea and Sasaki, Manami and Schlickeiser, Reinhard and Schussler, F. and Schulz, Andreas and Schwanke, U. and Schwemmer, S. and Seyffert, A. S. and Shafi, N. and Simoni, R. and Sol, H. and Spanier, Felix and Spengler, G. and Spiess, F. and Stawarz, Lukasz and Steenkamp, R. and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Tuffs, R. and van der Walt, Johan and van Eldik, Christopher and van Soelen, Brian and Vasileiadis, Georges and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, Jacco and Voisin, F. and Voelk, Heinrich J. and Vuillaume, Thomas and Wadiasingh, Z. and Wagner, Stefan J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, Alicja and Willmann, P. and Woernlein, A. and Wouters, Denis and Yang, R. and Zabalza, Victor and Zaborov, D. and Zacharias, M. and Zdziarski, A. A. and Zech, Andreas and Zefi, F. and Ziegler, A. and Zywucka, Natalia},
title = {Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS},
series = {Physical review letters},
volume = {117},
journal = {Physical review letters},
publisher = {American Physical Society},
address = {College Park},
organization = {HESS Collaboration},
issn = {0031-9007},
doi = {10.1103/PhysRevLett.117.111301},
pages = {6},
year = {2016},
abstract = {The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section . These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe values expected from the thermal relic density for TeV DM particles.},
language = {en}
}
@misc{AbramowskiAharonianBenkhalietal.2015,
author = {Abramowski, Attila and Aharonian, Felix A. and Benkhali, Faical Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Backes, Michael and Balenderan, Shangkari and Balzer, Arnim and Barnacka, Anna and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, Konrad and Birsin, E. and Biteau, Jonathan and B{\"o}ttcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Carrigan, Svenja and Casanova, Sabrina and Chadwick, Paula M. and Chakraborty, Nachiketa and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Conrad, Jan and Couturier, Claire and Cui, Yudong and Davids, Isak Delberth and Degrange, Bernhard and Deil, Christoph and deWilt, P. and Djannati-Ata{\"i}, A. and Domainko, Wilfried and Donath, Axel and Dubus, G. and Dutson, K. and Dyks, J. and Dyrda, M. and Edwards, Tanya and Egberts, Kathrin and Eger, Peter and Espigat, P. and Farnier, C. and Fegan, Stephen and Feinstein, Fabrice and Fernandes, Milton Virgilio and Fernandez, Diane and Fiasson, A. and Fontaine, Gerard and F{\"o}rster, Andreas and Fuessling, M. and Gabici, S. and Gajdus, M. and Gallant, Yves A. and Garrigoux, Tania and Giavitto, G. and Giebels, Berrie and Glicenstein, Jean-Francois and Gottschall, Daniel and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Haeffner, S. and Hahn, Joachim and Harris, Jonathan and Heinzelmann, G{\"o}tz and Henri, G. and Hermann, German and Hervet, O. and Hillert, Andreas and Hinton, James Anthony and Hofmann, Werner and Hofverberg, Petter and Holler, Markus and Horns, Dieter and Ivascenko, Alex and Jacholkowska, A. and Jahn, C. and Jamrozy, Marek and Janiak, M. and Jankowsky, F. and Jung-Richardt, I. and Kastendieck, Max Anton and Katarzynski, K. and Katz, U. and Kaufmann, S. and Khelifi, B. and Kieffer, Michel and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, David and Komin, Nu and Kosack, Karl and Krakau, Steffen and Krayzel, F. and Krueger, Pat P. and Laffon, H. and Lamanna, G. and Lefaucheur, J. and Lefranc, Valentin and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Lohse, Thomas and Lopatin, A. and Lu, Chia-Chun and Marandon, Vincent and Marcowith, Alexandre and Marx, Ramin and Maurin, G. and Maxted, Nigel and Mayer, Michael and McComb, T. J. Lowry and Mehault, J. and Meintjes, P. J. and Menzler, Ulf and Meyer, M. and Mitchell, Alison M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, Thomas and de Naurois, Mathieu and Niemiec, J. and Nolan, Sam J. and Oakes, Louise and Odaka, Hirokazu and Ohm, S. and Optiz, Bj{\"o}rn and Ostrowski, Michal and Oya, I. and Panter, Michael and Parsons, R. Daniel and Arribas, M. Paz and Pekeur, Nikki W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and P{\"u}hlhofer, Gerd and Punch, M. and Quirrenbach, A. and Raab, S. and Reichardt, I. and Reimer, Anita and Reimer, Olaf and Renaud, Metz and de los Reyes, Raquel and Rieger, Frank and Romoli, C. and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, Vardan and Salek, D. and Sanchez, David M. and Santangelo, Andrea and Schlickeiser, Reinhard and Schuessler, F. and Schulz, A. and Schwanke, Ullrich and Schwarzburg, S. and Schwemmer, S. and Sol, H. and Spanier, Felix and Spengler, G. and Spies, Franziska and Stawarz, Lukasz and Steenkamp, Riaan and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Valerius, K. and van Eldik, C. and van Soelen, B. and Vasileiadis, Georges and Veh, J. and Venter, Christo and Viana, Aion and Vincent, P. and Vink, Jacco and V{\"o}lk, Heinrich J. and Volpe, Francesca and Vorster, Martine and Vuillaume, T. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and Ward, Martin and Weidinger, Matthias and Weitzel, Quirin and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, Ruizhi and Zabalza, Victor and Zaborov, Dmitry and Zacharias, M. and Zdziarski, A. A. and Zech, Alraune and Zechlin, Hannes -S.},
title = {H.E.S.S. detection of TeV emission from the interaction region between the supernova remnant G349.7+0.2 and a molecular cloud (vol 574, A100, 2015)},
series = {Astronomy and astrophysics : an international weekly journal},
volume = {580},
journal = {Astronomy and astrophysics : an international weekly journal},
publisher = {EDP Sciences},
address = {Les Ulis},
organization = {HESS Collaboration},
issn = {1432-0746},
doi = {10.1051/0004-6361/201425070e},
pages = {2},
year = {2015},
language = {en}
}
@article{TuckerBoehningGaeseFaganetal.2018,
author = {Tucker, Marlee A. and Boehning-Gaese, Katrin and Fagan, William F. and Fryxell, John M. and Van Moorter, Bram and Alberts, Susan C. and Ali, Abdullahi H. and Allen, Andrew M. and Attias, Nina and Avgar, Tal and Bartlam-Brooks, Hattie and Bayarbaatar, Buuveibaatar and Belant, Jerrold L. and Bertassoni, Alessandra and Beyer, Dean and Bidner, Laura and van Beest, Floris M. and Blake, Stephen and Blaum, Niels and Bracis, Chloe and Brown, Danielle and de Bruyn, P. J. Nico and Cagnacci, Francesca and Calabrese, Justin M. and Camilo-Alves, Constanca and Chamaille-Jammes, Simon and Chiaradia, Andre and Davidson, Sarah C. and Dennis, Todd and DeStefano, Stephen and Diefenbach, Duane and Douglas-Hamilton, Iain and Fennessy, Julian and Fichtel, Claudia and Fiedler, Wolfgang and Fischer, Christina and Fischhoff, Ilya and Fleming, Christen H. and Ford, Adam T. and Fritz, Susanne A. and Gehr, Benedikt and Goheen, Jacob R. and Gurarie, Eliezer and Hebblewhite, Mark and Heurich, Marco and Hewison, A. J. Mark and Hof, Christian and Hurme, Edward and Isbell, Lynne A. and Janssen, Rene and Jeltsch, Florian and Kaczensky, Petra and Kane, Adam and Kappeler, Peter M. and Kauffman, Matthew and Kays, Roland and Kimuyu, Duncan and Koch, Flavia and Kranstauber, Bart and LaPoint, Scott and Leimgruber, Peter and Linnell, John D. C. and Lopez-Lopez, Pascual and Markham, A. Catherine and Mattisson, Jenny and Medici, Emilia Patricia and Mellone, Ugo and Merrill, Evelyn and Mourao, Guilherme de Miranda and Morato, Ronaldo G. and Morellet, Nicolas and Morrison, Thomas A. and Diaz-Munoz, Samuel L. and Mysterud, Atle and Nandintsetseg, Dejid and Nathan, Ran and Niamir, Aidin and Odden, John and Oliveira-Santos, Luiz Gustavo R. and Olson, Kirk A. and Patterson, Bruce D. and de Paula, Rogerio Cunha and Pedrotti, Luca and Reineking, Bjorn and Rimmler, Martin and Rogers, Tracey L. and Rolandsen, Christer Moe and Rosenberry, Christopher S. and Rubenstein, Daniel I. and Safi, Kamran and Said, Sonia and Sapir, Nir and Sawyer, Hall and Schmidt, Niels Martin and Selva, Nuria and Sergiel, Agnieszka and Shiilegdamba, Enkhtuvshin and Silva, Joao Paulo and Singh, Navinder and Solberg, Erling J. and Spiegel, Orr and Strand, Olav and Sundaresan, Siva and Ullmann, Wiebke and Voigt, Ulrich and Wall, Jake and Wattles, David and Wikelski, Martin and Wilmers, Christopher C. and Wilson, John W. and Wittemyer, George and Zieba, Filip and Zwijacz-Kozica, Tomasz and Mueller, Thomas},
title = {Moving in the Anthropocene},
series = {Science},
volume = {359},
journal = {Science},
number = {6374},
publisher = {American Assoc. for the Advancement of Science},
address = {Washington},
issn = {0036-8075},
doi = {10.1126/science.aam9712},
pages = {466 -- 469},
year = {2018},
abstract = {Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.},
language = {en}
}
@article{StolterfohtCaprioglioWolffetal.2019,
author = {Stolterfoht, Martin and Caprioglio, Pietro and Wolff, Christian Michael and Marquez, Jose A. and Nordmann, Joleik and Zhang, Shanshan and Rothhardt, Daniel and H{\"o}rmann, Ulrich and Amir, Yohai and Redinger, Alex and Kegelmann, Lukas and Zu, Fengshuo and Albrecht, Steve and Koch, Norbert and Kirchartz, Thomas and Saliba, Michael and Unold, Thomas and Neher, Dieter},
title = {The impact of energy alignment and interfacial recombination on the internal and external open-circuit voltage of perovskite solar cells},
series = {Energy \& environmental science},
volume = {12},
journal = {Energy \& environmental science},
number = {9},
publisher = {Royal Society of Chemistry},
address = {Cambridge},
issn = {1754-5692},
doi = {10.1039/c9ee02020a},
pages = {2778 -- 2788},
year = {2019},
abstract = {Charge transport layers (CTLs) are key components of diffusion controlled perovskite solar cells, however, they can induce additional non-radiative recombination pathways which limit the open circuit voltage (V-OC) of the cell. In order to realize the full thermodynamic potential of the perovskite absorber, both the electron and hole transport layer (ETL/HTL) need to be as selective as possible. By measuring the photoluminescence yield of perovskite/CTL heterojunctions, we quantify the non-radiative interfacial recombination currents in pin- and nip-type cells including high efficiency devices (21.4\%). Our study comprises a wide range of commonly used CTLs, including various hole-transporting polymers, spiro-OMeTAD, metal oxides and fullerenes. We find that all studied CTLs limit the V-OC by inducing an additional non-radiative recombination current that is in most cases substantially larger than the loss in the neat perovskite and that the least-selective interface sets the upper limit for the V-OC of the device. Importantly, the V-OC equals the internal quasi-Fermi level splitting (QFLS) in the absorber layer only in high efficiency cells, while in poor performing devices, the V-OC is substantially lower than the QFLS. Using ultraviolet photoelectron spectroscopy and differential charging capacitance experiments we show that this is due to an energy level mis-alignment at the p-interface. The findings are corroborated by rigorous device simulations which outline important considerations to maximize the V-OC. This work highlights that the challenge to suppress non-radiative recombination losses in perovskite cells on their way to the radiative limit lies in proper energy level alignment and in suppression of defect recombination at the interfaces.},
language = {en}
}
@article{SeroussiNowickiSimonetal.2019,
author = {Seroussi, Helene and Nowicki, Sophie and Simon, Erika and Abe-Ouchi, Ayako and Albrecht, Torsten and Brondex, Julien and Cornford, Stephen and Dumas, Christophe and Gillet-Chaulet, Fabien and Goelzer, Heiko and Golledge, Nicholas R. and Gregory, Jonathan M. and Greve, Ralf and Hoffman, Matthew J. and Humbert, Angelika and Huybrechts, Philippe and Kleiner, Thomas and Larourl, Eric and Leguy, Gunter and Lipscomb, William H. and Lowry, Daniel and Mengel, Matthias and Morlighem, Mathieu and Pattyn, Frank and Payne, Anthony J. and Pollard, David and Price, Stephen F. and Quiquet, Aurelien and Reerink, Thomas J. and Reese, Ronja and Rodehacke, Christian B. and Schlegel, Nicole-Jeanne and Shepherd, Andrew and Sun, Sainan and Sutter, Johannes and Van Breedam, Jonas and van de Wal, Roderik S. W. and Winkelmann, Ricarda and Zhang, Tong},
title = {initMIP-Antarctica},
series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union},
volume = {13},
journal = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union},
number = {5},
publisher = {Copernicus},
address = {G{\"o}ttingen},
issn = {1994-0416},
doi = {10.5194/tc-13-1441-2019},
pages = {1441 -- 1471},
year = {2019},
abstract = {Ice sheet numerical modeling is an important tool to estimate the dynamic contribution of the Antarctic ice sheet to sea level rise over the coming centuries. The influence of initial conditions on ice sheet model simulations, however, is still unclear. To better understand this influence, an initial state intercomparison exercise (initMIP) has been developed to compare, evaluate, and improve initialization procedures and estimate their impact on century-scale simulations. initMlP is the first set of experiments of the Ice Sheet Model Intercomparison Project for CMIP6 (ISMIP6), which is the primary Coupled Model Intercomparison Project Phase 6 (CMIP6) activity focusing on the Greenland and Antarctic ice sheets. Following initMlP-Greenland, initMlP-Antarctica has been designed to explore uncertainties associated with model initialization and spin-up and to evaluate the impact of changes in external forcings. Starting from the state of the Antarctic ice sheet at the end of the initialization procedure, three forward experiments are each run for 100 years: a control run, a run with a surface mass balance anomaly, and a run with a basal melting anomaly beneath floating ice. This study presents the results of initMlP-Antarctica from 25 simulations performed by 16 international modeling groups. The submitted results use different initial conditions and initialization methods, as well as ice flow model parameters and reference external forcings. We find a good agreement among model responses to the surface mass balance anomaly but large variations in responses to the basal melting anomaly. These variations can be attributed to differences in the extent of ice shelves and their upstream tributaries, the numerical treatment of grounding line, and the initial ocean conditions applied, suggesting that ongoing efforts to better represent ice shelves in continental-scale models should continue.},
language = {en}
}
@article{HeinrichBalanzateguiBensetal.2018,
author = {Heinrich, Ingo and Balanzategui, Daniel and Bens, Oliver and Blasch, Gerald and Blume, Theresa and Boettcher, Falk and Borg, Erik and Brademann, Brian and Brauer, Achim and Conrad, Christopher and Dietze, Elisabeth and Dr{\"a}ger, Nadine and Fiener, Peter and Gerke, Horst H. and G{\"u}ntner, Andreas and Heine, Iris and Helle, Gerhard and Herbrich, Marcus and Harfenmeister, Katharina and Heussner, Karl-Uwe and Hohmann, Christian and Itzerott, Sibylle and Jurasinski, Gerald and Kaiser, Knut and Kappler, Christoph and Koebsch, Franziska and Liebner, Susanne and Lischeid, Gunnar and Merz, Bruno and Missling, Klaus Dieter and Morgner, Markus and Pinkerneil, Sylvia and Plessen, Birgit and Raab, Thomas and Ruhtz, Thomas and Sachs, Torsten and Sommer, Michael and Spengler, Daniel and Stender, Vivien and St{\"u}ve, Peter and Wilken, Florian},
title = {Interdisciplinary Geo-ecological Research across Time Scales in the Northeast German Lowland Observatory (TERENO-NE)},
series = {Vadose zone journal},
volume = {17},
journal = {Vadose zone journal},
number = {1},
publisher = {Soil Science Society of America},
address = {Madison},
issn = {1539-1663},
doi = {10.2136/vzj2018.06.0116},
pages = {25},
year = {2018},
abstract = {The Northeast German Lowland Observatory (TERENO-NE) was established to investigate the regional impact of climate and land use change. TERENO-NE focuses on the Northeast German lowlands, for which a high vulnerability has been determined due to increasing temperatures and decreasing amounts of precipitation projected for the coming decades. To facilitate in-depth evaluations of the effects of climate and land use changes and to separate the effects of natural and anthropogenic drivers in the region, six sites were chosen for comprehensive monitoring. In addition, at selected sites, geoarchives were used to substantially extend the instrumental records back in time. It is this combination of diverse disciplines working across different time scales that makes the observatory TERENO-NE a unique observation platform. We provide information about the general characteristics of the observatory and its six monitoring sites and present examples of interdisciplinary research activities at some of these sites. We also illustrate how monitoring improves process understanding, how remote sensing techniques are fine-tuned by the most comprehensive ground-truthing site DEMMIN, how soil erosion dynamics have evolved, how greenhouse gas monitoring of rewetted peatlands can reveal unexpected mechanisms, and how proxy data provides a long-term perspective of current ongoing changes.},
language = {en}
}
@article{DiekmannAndresBeckeretal.2019,
author = {Diekmann, Martin and Andres, Christian and Becker, Thomas and Bennie, Jonathan and Blueml, Volker and Bullock, James M. and Culmsee, Heike and Fanigliulo, Miriam and Hahn, Annett and Heinken, Thilo and Leuschner, Christoph and Luka, Stefanie and Meissner, Justus and M{\"u}ller, Josef and Newton, Adrian and Peppler-Lisbach, Cord and Rosenthal, Gert and van den Berg, Leon J. L. and Vergeer, Philippine and Wesche, Karsten},
title = {Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe},
series = {Journal of vegetation science},
volume = {30},
journal = {Journal of vegetation science},
number = {2},
publisher = {Wiley},
address = {Hoboken},
issn = {1100-9233},
doi = {10.1111/jvs.12727},
pages = {187 -- 202},
year = {2019},
abstract = {Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species.},
language = {en}
}
@inproceedings{CurzonKalasSchubertetal.2015,
author = {Curzon, Paul and Kalas, Ivan and Schubert, Sigrid and Schaper, Niclas and Barnes, Jan and Kennewell, Steve and Br{\"o}ker, Kathrin and Kastens, Uwe and Magenheim, Johannes and Dagiene, Valentina and Stupuriene, Gabriele and Ellis, Jason Brent and Abreu-Ellis, Carla Reis and Grillenberger, Andreas and Romeike, Ralf and Haugsbakken, Halvdan and Jones, Anthony and Lewin, Cathy and McNicol, Sarah and Nelles, Wolfgang and Neugebauer, Jonas and Ohrndorf, Laura and Schaper, Niclas and Schubert, Sigrid and Opel, Simone and Kramer, Matthias and Trommen, Michael and Pottb{\"a}cker, Florian and Ilaghef, Youssef and Passig, David and Tzuriel, David and Kedmi, Ganit Eshel and Saito, Toshinori and Webb, Mary and Weigend, Michael and Bottino, Rosa and Chioccariello, Augusto and Christensen, Rhonda and Knezek, Gerald and Gioko, Anthony Maina and Angondi, Enos Kiforo and Waga, Rosemary and Ohrndorf, Laura and Or-Bach, Rachel and Preston, Christina and Younie, Sarah and Przybylla, Mareen and Romeike, Ralf and Reynolds, Nicholas and Swainston, Andrew and Bendrups, Faye and Sysło, Maciej M. and Kwiatkowska, Anna Beata and Zieris, Holger and Gerstberger, Herbert and M{\"u}ller, Wolfgang and B{\"u}chner, Steffen and Opel, Simone and Schiller, Thomas and Wegner, Christian and Zender, Raphael and Lucke, Ulrike and Diethelm, Ira and Syrbe, J{\"o}rn and Lai, Kwok-Wing and Davis, Niki and Eickelmann, Birgit and Erstad, Ola and Fisser, Petra and Gibson, David and Khaddage, Ferial and Knezek, Gerald and Micheuz, Peter and Kloos, Carlos Delgado},
title = {KEYCIT 2014},
editor = {Brinda, Torsten and Reynolds, Nicholas and Romeike, Ralf and Schwill, Andreas},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
isbn = {978-3-86956-292-6},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-70325},
pages = {438},
year = {2015},
abstract = {In our rapidly changing world it is increasingly important not only to be an expert in a chosen field of study but also to be able to respond to developments, master new approaches to solving problems, and fulfil changing requirements in the modern world and in the job market. In response to these needs key competencies in understanding, developing and using new digital technologies are being brought into focus in school and university programmes. The IFIP TC3 conference "KEYCIT - Key Competences in Informatics and ICT (KEYCIT 2014)" was held at the University of Potsdam in Germany from July 1st to 4th, 2014 and addressed the combination of key competencies, Informatics and ICT in detail. The conference was organized into strands focusing on secondary education, university education and teacher education (organized by IFIP WGs 3.1 and 3.3) and provided a forum to present and to discuss research, case studies, positions, and national perspectives in this field.},
language = {en}
}
@article{OttoMareljaSchoofsetal.2018,
author = {Otto, Nils and Marelja, Zvonimir and Schoofs, Andreas and Kranenburg, Holger and Bittern, Jonas and Yildirim, Kerem and Berh, Dimitri and Bethke, Maria and Thomas, Silke and Rode, Sandra and Risse, Benjamin and Jiang, Xiaoyi and Pankratz, Michael and Leimk{\"u}hler, Silke and Kl{\"a}mbt, Christian},
title = {The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia},
series = {Nature Communications},
volume = {9},
journal = {Nature Communications},
publisher = {Nature Publ. Group},
address = {London},
issn = {2041-1723},
doi = {10.1038/s41467-018-05645-z},
pages = {12},
year = {2018},
abstract = {Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity.},
language = {en}
}
@article{WangFritzschBernardingetal.2013,
author = {Wang, Jing and Fritzsch, Claire and Bernarding, Johannes and Krause, Thomas and Mauritz, Karl-Heinz and Brunetti, Maddalena and Dohle, Christian},
title = {Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects},
series = {Neurorehabilitation : an interdisciplinary journal},
volume = {33},
journal = {Neurorehabilitation : an interdisciplinary journal},
number = {4},
publisher = {IOS Press},
address = {Amsterdam},
issn = {1053-8135},
doi = {10.3233/NRE-130999},
pages = {593 -- 603},
year = {2013},
abstract = {BACKGROUND: Mirror therapy (MT) was found to improve motor function after stroke, but its neural mechanisms remain unclear, especially in single stroke patients. OBJECTIVES: The following imaging study was designed to compare brain activation patterns evoked by the mirror illusion in single stroke patients with normal subjects. METHODS: Fifteen normal volunteers and five stroke patients with severe arm paresis were recruited. Cerebral activations during movement mirroring by means of a video chain were recorded with functional magnetic resonance imaging (fMRI). Single-subject analysis was performed using SPM 8. RESULTS: For normal subjects, ten and thirteen subjects displayed lateralized cerebral activations evoked by the mirror illusion while moving their right and left hand respectively. The magnitude of this effect in the precuneus contralateral to the seen hand was not dependent on movement speed or subjective experience. Negative correlation of activation strength with age was found for the right hand only. The activation pattern in stroke patients is comparable to that of normal subjects and present in four out of five patients. CONCLUSIONS: In summary, the mirror illusion can elicit cerebral activation contralateral to the perceived hand in the majority of single normal subjects, but not in all of them. This is similar even in stroke patients with severe hemiparesis.},
language = {en}
}
@article{KieferClaesNzayisengaetal.2015,
author = {Kiefer, Christian S. and Claes, Andrea R. and Nzayisenga, Jean-Claude and Pietra, Stefano and Stanislas, Thomas and Ikeda, Yoshihisa and Grebe, Markus},
title = {Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity},
series = {Development},
journal = {Development},
number = {142},
doi = {doi: 10.1242/dev.111013},
pages = {151 -- 161},
year = {2015},
abstract = {The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.},
language = {en}
}
@phdthesis{Thomas2003,
author = {Thomas, Arne Christian},
title = {Por{\"o}se Silikate durch Nanocasting : von chiralen Templaten zu neuer Chemie in Poren},
pages = {112 S.},
year = {2003},
language = {de}
}
@article{LewinKamjunkeMehner2003,
author = {Lewin, Wolf-Christian and Kamjunke, Norbert and Mehner, Thomas},
title = {Phosphorus uptake by Microcystis during passage through fish guts},
year = {2003},
abstract = {Herbivorous fish feed on cyanobacteria. Digestability differs, however, between cyanobacteria species without mucous cover and mucilaginous genera such as Microcystis. The latter can pass fish guts almost undamaged, and it has been hypothesized that they can take up nutrients during gut passage. Here we tested whether live Microcystis, as food for juvenile roach labeled with 33P, indeed showed higher radioactivity after gut passage as compared to gut contents in control experiments with fish fed heated Microcystis. Microcystis showed high viability after passage through roach guts, and live colonies had a significantly higher radioactivity than dead ones. We conclude that Microcystis is protected against digestion in roach guts and can directly use the phosphorus supplied in the fish guts during passage.},
language = {en}
}
@article{AngerKonczakLinke2002,
author = {Anger, Christian and Konczak, Kathrin and Linke, Thomas},
title = {NoMoRe: A system for non-monotonic reasoning with logic programs under answer set semantics},
isbn = {3-540-42254-4},
year = {2002},
language = {en}
}
@article{LinkeAngerKonczak2002,
author = {Linke, Thomas and Anger, Christian and Konczak, Kathrin},
title = {More on nomore},
isbn = {3-540-44190-5},
year = {2002},
language = {en}
}
@article{DorschDoerfler2014,
author = {Dorsch, Christian and D{\"o}rfler, Thomas},
title = {Organized hypocrisy of the international community},
series = {Zeitschrift f{\"u}r Genozidforschung},
volume = {15},
journal = {Zeitschrift f{\"u}r Genozidforschung},
number = {1-2},
publisher = {Velbr{\"u}ck Wissenschaft},
address = {Weilerswist},
issn = {1438-8332},
doi = {10.5771/1438-8332-2014-1-2-8},
pages = {8 -- 31},
year = {2014},
language = {en}
}
@misc{ThomasLietz2019,
author = {Thomas, Linda and Lietz, Christian},
title = {Maßnahmen zur Erh{\"o}hung der Sichtbarkeit des wissenschaftlichen Outputs},
doi = {10.25932/publishup-47347},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473473},
pages = {13},
year = {2019},
abstract = {Die Universit{\"a}t Potsdam hat 2018 zum zweiten Mal erfolgreich am Times Higher Education-Ranking (THE-Ranking) teilgenommen. Hierf{\"u}r wurde erneut das Publikationsaufkommen inklusive der Verbreitung der IDs von Autorinnen und Autoren, wie bspw. ORCiD, Researcher-ID oder Google Scholar-ID, ermittelt. Die aus den Erkenntnissen der ersten bibliometrischen Output-Analyse abgeleiteten Maßnahmen wurden nun hinsichtlich ihrer Wirksamkeit beurteilt. Der vorliegende Artikel vergleicht die Ergebnisse beider Analysen und thematisiert die Entwicklungen und Implikationen seit dem Ergreifen der ersten Maßnahmen.},
language = {de}
}
@article{vonLoeffelholzLieskeNeuschaeferRubeetal.2017,
author = {von Loeffelholz, Christian and Lieske, Stefanie and Neuschaefer-Rube, Frank and Willmes, Diana M. and Raschzok, Nathanael and Sauer, Igor M. and K{\"o}nig, J{\"o}rg and Fromm, Martin F. and Horn, Paul and Chatzigeorgiou, Antonios and Pathe-Neuschaefer-Rube, Andrea and Jordan, Jens and Pfeiffer, Andreas F. H. and Mingrone, Geltrude and Bornstein, Stefan R. and Stroehle, Peter and Harms, Christoph and Wunderlich, F. Thomas and Helfand, Stephen L. and Bernier, Michel and de Cabo, Rafael and Shulman, Gerald I. and Chavakis, Triantafyllos and P{\"u}schel, Gerhard Paul and Birkenfeld, Andreas L.},
title = {The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism},
series = {Hepatology},
volume = {66},
journal = {Hepatology},
number = {2},
publisher = {Wiley},
address = {Hoboken},
issn = {0270-9139},
doi = {10.1002/hep.29089},
pages = {616 -- 630},
year = {2017},
abstract = {Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450.},
language = {en}
}
@article{HolzmeierWolfGiengeretal.2018,
author = {Holzmeier, Fabian and Wolf, Thomas J. A. and Gienger, Christian and Wagner, Isabella and Bozek, J. and Nandi, S. and Nicolas, C. and Fischer, Ingo and G{\"u}hr, Markus and Fink, Reinhold F.},
title = {Normal and resonant Auger spectroscopy of isocyanic acid, HNCO},
series = {The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr},
volume = {149},
journal = {The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr},
number = {3},
publisher = {American Institute of Physics},
address = {Melville},
issn = {0021-9606},
doi = {10.1063/1.5030621},
pages = {13},
year = {2018},
abstract = {In this paper, we investigate HNCO by resonant and nonresonant Auger electron spectroscopy at the K-edges of carbon, nitrogen, and oxygen, employing soft X-ray synchrotron radiation. In comparison with the isosteric but linear CO2 molecule, spectra of the bent HNCO molecule are similar but more complex due to its reduced symmetry, wherein the degeneracy of the π-orbitals is lifted. Resonant Auger electron spectra are presented at different photon energies over the first core-excited 1s → 10a′ resonance. All Auger electron spectra are assigned based on ab initio configuration interaction computations combined with the one-center approximation for Auger intensities and moment theory to consider vibrational motion. The calculated spectra were scaled by a newly introduced energy scaling factor, and generally, good agreement is found between experiment and theory for normal as well as resonant Auger electron spectra. A comparison of resonant Auger spectra with nonresonant Auger structures shows a slight broadening as well as a shift of the former spectra between -8 and -9 eV due to the spectating electron. Since HNCO is a small molecule and contains the four most abundant atoms of organic molecules, the reported Auger electron decay spectra will provide a benchmark for further theoretical approaches in the computation of core electron spectra.},
language = {en}
}
@article{LehrDannowskiKalettkaetal.2018,
author = {Lehr, Christian and Dannowski, Ralf and Kalettka, Thomas and Merz, Christoph and Schr{\"o}der, Boris and Steidl, J{\"o}rg and Lischeid, Gunnar},
title = {Detecting dominant changes in irregularly sampled multivariate water quality data sets},
series = {Hydrology and earth system sciences : HESS},
volume = {22},
journal = {Hydrology and earth system sciences : HESS},
number = {8},
publisher = {Copernicus},
address = {G{\"o}ttingen},
issn = {1027-5606},
doi = {10.5194/hess-22-4401-2018},
pages = {4401 -- 4424},
year = {2018},
abstract = {Time series of groundwater and stream water quality often exhibit substantial temporal and spatial variability, whereas typical existing monitoring data sets, e.g. from environmental agencies, are usually characterized by relatively low sampling frequency and irregular sampling in space and/or time. This complicates the differentiation between anthropogenic influence and natural variability as well as the detection of changes in water quality which indicate changes in single drivers. We suggest the new term "dominant changes" for changes in multivariate water quality data which concern (1) multiple variables, (2) multiple sites and (3) long-term patterns and present an exploratory framework for the detection of such dominant changes in data sets with irregular sampling in space and time. Firstly, a non-linear dimension-reduction technique was used to summarize the dominant spatiotemporal dynamics in the multivariate water quality data set in a few components. Those were used to derive hypotheses on the dominant drivers influencing water quality. Secondly, different sampling sites were compared with respect to median component values. Thirdly, time series of the components at single sites were analysed for long-term patterns. We tested the approach with a joint stream water and groundwater data set quality consisting of 1572 samples, each comprising sixteen variables, sampled with a spatially and temporally irregular sampling scheme at 29 sites in northeast Germany from 1998 to 2009. The first four components were interpreted as (1) an agriculturally induced enhancement of the natural background level of solute concentration, (2) a redox sequence from reducing conditions in deep groundwater to post-oxic conditions in shallow groundwater and oxic conditions in stream water, (3) a mixing ratio of deep and shallow groundwater to the streamflow and (4) sporadic events of slurry application in the agricultural practice. Dominant changes were observed for the first two components. The changing intensity of the first component was interpreted as response to the temporal variability of the thickness of the unsaturated zone. A steady increase in the second component at most stream water sites pointed towards progressing depletion of the denitrification capacity of the deep aquifer.},
language = {en}
}
@article{RollnikAdolphsenBaueretal.2017,
author = {Rollnik, Jens D. and Adolphsen, Jens and Bauer, J. and Bertram, Maja and Brocke, Jan and Dohmen, Christian and Donauer, E. and Hartwich, Mathias and Heidler, Maria Dorothea and Huge, Volker and Klarmann, Silke and Lorenzl, Stefan and L{\"u}ck, Michelle and Mertl-R{\"o}tzer, Marion and Mokrusch, Thomas and Nowak, D. A. and Platz, Tanja and Riechmann, Lutz and Schlachetzki, Felix and von Helden, Alvin and Wallesch, C. W. and Zergiebel, D. and Pohl, M.},
title = {Prolongiertes Weaning in der neurologisch-neurochirurgischen Fr{\"u}hrehabilitation},
series = {Der Nervenarzt: Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
volume = {88},
journal = {Der Nervenarzt: Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
publisher = {Springer},
address = {New York},
issn = {0028-2804},
doi = {10.1007/s00115-017-0332-0},
pages = {652 -- 674},
year = {2017},
abstract = {Prolonged weaning of patients with neurological or neurosurgery disorders is associated with specific characteristics, which are taken into account by the German Society for Neurorehabilitation (DGNR) in its own guideline. The current S2k guideline of the German Society for Pneumology and Respiratory Medicine is referred to explicitly with regard to definitions (e.g., weaning and weaning failure), weaning categories, pathophysiology of weaning failure, and general weaning strategies. In early neurological and neurosurgery rehabilitation, patients with central of respiratory regulation disturbances (e.g., cerebral stem lesions), swallowing disturbances (neurogenic dysphagia), neuromuscular problems (e.g., critical illness polyneuropathy, Guillain-Barre syndrome, paraplegia, Myasthenia gravis) and/or cognitive disturbances (e.g., disturbed consciousness and vigilance disorders, severe communication disorders), whose care during the weaning of ventilation requires, in addition to intensive medical competence, neurological or neurosurgical and neurorehabilitation expertise. In Germany, this competence is present in centers of early neurological and neurosurgery rehabilitation, as a hospital treatment. The guideline is based on a systematic search of guideline databases and MEDLINE. Consensus was established by means of a nominal group process and Delphi procedure moderated by the Association of the Scientific Medical Societies in Germany (AWMF). In the present guideline of the DGNR, the special structural and substantive characteristics of early neurological and neurosurgery rehabilitation and existing studies on weaning in early rehabilitation facilities are examined. Addressees of the guideline are neurologists, neurosurgeons, anesthesiologists, palliative physicians, speech therapists, intensive care staff, ergotherapists, physiotherapists, and neuropsychologists. In addition, this guideline is intended to provide information to specialists for physical medicine and rehabilitation (PMR), pneumologists, internists, respiratory therapists, the German Medical Service of Health Insurance Funds (MDK) and the German Association of Health Insurance Funds (MDS). The main goal of this guideline is to convey the current knowledge on the subject of "Prolonged weaning in early neurological and neurosurgery rehabilitation".},
language = {de}
}
@article{LischeidKalettkaHollaenderetal.2018,
author = {Lischeid, Gunnar and Kalettka, Thomas and Holl{\"a}nder, Matthias and Steidl, J{\"o}rg and Merz, Christoph and Dannowski, Ralf and Hohenbrink, Tobias Ludwig and Lehr, Christian and Onandia, Gabriela and Reverey, Florian and P{\"a}tzig, Marlene},
title = {Natural ponds in an agricultural landscape},
series = {Limnologica : ecology and management of inland waters},
volume = {68},
journal = {Limnologica : ecology and management of inland waters},
publisher = {Elsevier GMBH},
address = {M{\"u}nchen},
issn = {0075-9511},
doi = {10.1016/j.limno.2017.01.003},
pages = {5 -- 16},
year = {2018},
abstract = {The pleistocenic landscape in North Europe, North Asia and North America is spotted with thousands of natural ponds called kettle holes. They are biological and biogeochemical hotspots. Due to small size, small perimeter and shallow depth biological and biogeochemical processes in kettle holes are closely linked to the dynamics and the emissions of the terrestrial environment. On the other hand, their intriguing high spatial and temporal variability makes a sound understanding of the terrestrial-aquatic link very difficult. It is presumed that intensive agricultural land use during the last decades has resulted in a ubiquitous high nutrient load. However, the water quality encountered at single sites highly depends on internal biogeochemical processes and thus can differ substantially even between adjacent sites. This study aimed at elucidating the interplay between external drivers and internal processes based on a thorough analysis of a comprehensive kettle hole water quality data set. To study the role of external drivers, effects of land use in the adjacent terrestrial environment, effects of vegetation at the interface between terrestrial and aquatic systems, and that of kettle hole morphology on water quality was investigated. None of these drivers was prone to strong with-in year variability. Thus temporal variability of spatial patterns could point to the role of internal biogeochemical processes. To that end, the temporal stability of the respective spatial patterns was studied as well for various solutes. All of these analyses were performed for a set of different variables. Different results for different solutes were then used as a source of information about the respective driving processes. In the Quillow catchment in the Uckermark region, about 100 km north of Berlin, Germany, 62 kettle holes have been regularly sampled since 2013. Kettle hole catchments were determined based on a groundwater level map of the uppermost aquifer. The catchments were not clearly related to topography. Spatial patterns of kettle hole water concentration of (earth) alkaline metals and chloride were fairly stable, presumably reflecting solute concentration of the uppermost aquifer. In contrast, spatial patterns of nutrients and redox-sensitive solutes within the kettle holes were hardly correlated between different sampling campaigns. Correspondingly, effects of season, hydrogeomorphic kettle hole type, shore vegetation or land use in the respective catchments were significant but explained only a minor portion of the total variance. It is concluded that internal processes mask effects of the terrestrial environment. There is some evidence that denitrification and phosphorus release from the sediment during frequent periods of hypoxia might play a major role. The latter seems to boost primary production occasionally. These processes do not follow a clear seasonal pattern and are still not well understood.},
language = {en}
}
@article{SaussenthalerOuniBaumeieretal.2019,
author = {Saussenthaler, Sophie and Ouni, Meriem and Baumeier, Christian and Schwerbel, Kristin and Gottmann, Pascal and Christmann, Sabrina and Laeger, Thomas and Sch{\"u}rmann, Annette},
title = {Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein},
series = {The journal of nutritional biochemistry},
volume = {63},
journal = {The journal of nutritional biochemistry},
publisher = {Elsevier},
address = {New York},
issn = {0955-2863},
doi = {10.1016/j.jnutbio.2018.09.025},
pages = {109 -- 116},
year = {2019},
abstract = {Dipeptidyl peptidase 4 (DPP4) is known to be elevated in metabolic disturbances such as obesity, type 2 diabetes and fatty liver disease. Lowering DPP4 concentration by pharmacological inhibition improves glucose homeostasis and exhibits beneficial effects to reduce hepatic fat content. As factors regulating the endogenous expression of Dpp4 are unknown, the aim of this study was to examine whether the Dpp4 expression is epigenetically regulated in response to dietary components. Primary hepatocytes were treated with different macronutrients, and Dpp4 mRNA levels and DPP4 activity were evaluated. Moreover, dietary low-protein intervention was conducted in New Zealand obese (NZO) mice, and subsequently, effects on Dpp4 expression, methylation as well as plasma concentration and activity were determined. Our results indicate that Dpp4 mRNA expression is mediated by DNA methylation in several tissues. We therefore consider the Dpp4 southern shore as tissue differentially methylated region. Amino acids increased Dpp4 expression in primary hepatocytes, whereas glucose and fatty acids were without effect. Dietary protein restriction in NZO mice increased Dpp4 DNA methylation in liver leading to diminished Dpp4 expression and consequently to lowered plasma DPP4 activity. We conclude that protein restriction in the adolescent and adult states is a sufficient strategy to reduce DPP4 which in turn contributes to improve glucose homeostasis. (C) 2018 Published by Elsevier Inc.},
language = {en}
}
@article{MuellerFoerstendorfSteudtneretal.2019,
author = {M{\"u}ller, Katharina and Foerstendorf, Harald and Steudtner, Robin and Tsushima, Satoru and Kumke, Michael Uwe and Lef{\`e}vre, Gr{\´e}gory and Rothe, J{\"o}rg and Mason, Harris and Szab{\´o}, Zolt{\´a}n and Yang, Ping and Adam, Christian K. R. and Andr{\´e}, R{\´e}mi and Brennenstuhl, Katlen and Chiorescu, Ion and Cho, Herman M. and Creff, Ga{\"e}lle and Coppin, Fr{\´e}d{\´e}ric and Dardenne, Kathy and Den Auwer, Christophe and Drobot, Bj{\"o}rn and Eidner, Sascha and Hess, Nancy J. and Kaden, Peter and Kremleva, Alena and Kretzschmar, Jerome and Kr{\"u}ger, Sven and Platts, James A. and Panak, Petra and Polly, Robert and Powell, Brian A. and Rabung, Thomas and Redon, Roland and Reiller, Pascal E. and R{\"o}sch, Notker and Rossberg, Andr{\´e} and Scheinost, Andreas C. and Schimmelpfennig, Bernd and Schreckenbach, Georg and Skerencak-Frech, Andrej and Sladkov, Vladimir and Solari, Pier Lorenzo and Wang, Zheming and Washton, Nancy M. and Zhang, Xiaobin},
title = {Interdisciplinary Round-Robin Test on molecular spectroscopy of the U(VI) Acetate System},
series = {ACS omega / American Chemical Society},
volume = {4},
journal = {ACS omega / American Chemical Society},
number = {5},
publisher = {American Chemical Society},
address = {Washington},
issn = {2470-1343},
doi = {10.1021/acsomega.9b00164},
pages = {8167 -- 8177},
year = {2019},
abstract = {A comprehensive molecular analysis of a simple aqueous complexing system. U(VI) acetate. selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). Twenty laboratories from six different countries with a focus on actinide or geochemical research participated and contributed to this scientific endeavor. The outcomes of this RRT were considered on two levels of complexity: first, within each technical discipline, conformities as well as discrepancies of the results and their sources were evaluated. The raw data from the different experimental approaches were found to be generally consistent. In particular, for complex setups such as accelerator-based X-ray absorption spectroscopy, the agreement between the raw data was high. By contrast, luminescence spectroscopic data turned out to be strongly related to the chosen acquisition parameters. Second, the potentials and limitations of coupling various spectroscopic and theoretical approaches for the comprehensive study of actinide molecular complexes were assessed. Previous spectroscopic data from the literature were revised and the benchmark data on the U(VI) acetate system provided an unambiguous molecular interpretation based on the correlation of spectroscopic and theoretical results. The multimethodologic approach and the conclusions drawn address not only important aspects of actinide spectroscopy but particularly general aspects of modern molecular analytical chemistry.},
language = {en}
}
@misc{LowHentschelStoberetal.2017,
author = {Low, Thomas and Hentschel, Christian and Stober, Sebastian and Sack, Harald and N{\"u}rnberger, Andreas},
title = {Exploring large movie collections},
series = {Lecture notes in computer science},
volume = {10133},
journal = {Lecture notes in computer science},
editor = {Amsaleg, Laurent and Guðmundsson, Gylfi Þ{\´o}r and Gurrin, Cathal and J{\´o}nsson, Bj{\"o}rn Þ{\´o}r and Satoh, Shin'ichi},
publisher = {Springer},
address = {Cham},
isbn = {978-3-319-51814-5},
issn = {0302-9743},
doi = {10.1007/978-3-319-51814-5_17},
pages = {198 -- 208},
year = {2017},
abstract = {We compare Visual Berrypicking, an interactive approach allowing users to explore large and highly faceted information spaces using similarity-based two-dimensional maps, with traditional browsing techniques. For large datasets, current projection methods used to generate maplike overviews suffer from increased computational costs and a loss of accuracy resulting in inconsistent visualizations. We propose to interactively align inexpensive small maps, showing local neighborhoods only, which ideally creates the impression of panning a large map. For evaluation, we designed a web-based prototype for movie exploration and compared it to the web interface of The Movie Database (TMDb) in an online user study. Results suggest that users are able to effectively explore large movie collections by hopping from one neighborhood to the next. Additionally, due to the projection of movie similarities, interesting links between movies can be found more easily, and thus, compared to browsing serendipitous discoveries are more likely.},
language = {en}
}
@book{AndraeEbertGarbevonKuczkowskietal.2009,
author = {Andrae, Marianne and Ebert, Johannes and Garbe-von Kuczkowski, Angela and Garbe, Roland and Grabow, Christian and Klees-Wambach, Marie-Luise and Kofler, Rolf and Mittmann, Michael and Nickel, Michael and N{\"o}then, Thomas and Schrader-Kroschewski, Karen and Schramm, Barbara and Ulrich, Christoph},
title = {Verfahren in Familiensachen : FamFG ; ZPO ; BGB},
series = {Nomos ProzessHandbuch},
journal = {Nomos ProzessHandbuch},
editor = {Garbe, Roland},
publisher = {Nomos; Beck-Online},
address = {Baden-Baden; M{\"u}nchen},
isbn = {978-3-8329-3973-1},
pages = {1200 S.},
year = {2009},
language = {de}
}
@misc{OttoMareljaSchoofsetal.2018,
author = {Otto, Nils and Marelja, Zvonimir and Schoofs, Andreas and Kranenburg, Holger and Bittern, Jonas and Yildirim, Kerem and Berh, Dimitri and Bethke, Maria and Thomas, Silke and Rode, Sandra and Risse, Benjamin and Jiang, Xiaoyi and Pankratz, Michael and Leimk{\"u}hler, Silke and Kl{\"a}mbt, Christian},
title = {The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia},
series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
number = {975},
issn = {1866-8372},
doi = {10.25932/publishup-42620},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-426205},
pages = {14},
year = {2018},
abstract = {Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity.},
language = {en}
}
@article{KabelitzBrzezinkaFriedrichetal.2016,
author = {Kabelitz, Tina and Brzezinka, Krzysztof and Friedrich, Thomas and Gorka, Michal and Graf, Alexander and Kappel, Christian and B{\"a}urle, Isabel},
title = {A JUMONJI Protein with E3 Ligase and Histone H3 Binding Activities Affects Transposon Silencing in Arabidopsis},
series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
volume = {171},
journal = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
publisher = {American Society of Plant Physiologists},
address = {Rockville},
issn = {0032-0889},
doi = {10.1104/pp.15.01688},
pages = {344 -- 358},
year = {2016},
abstract = {Transposable elements (TEs) make up a large proportion of eukaryotic genomes. As their mobilization creates genetic variation that threatens genome integrity, TEs are epigenetically silenced through several pathways, and this may spread to neighboring sequences. JUMONJI (JMJ) proteins can function as antisilencing factors and prevent silencing of genes next to TEs. Whether TE silencing is counterbalanced by the activity of antisilencing factors is still unclear. Here, we characterize JMJ24 as a regulator of TE silencing. We show that loss of JMJ24 results in increased silencing of the DNA transposon AtMu1c, while overexpression of JMJ24 reduces silencing. JMJ24 has a JumonjiC (JmjC) domain and two RING domains. JMJ24 autoubiquitinates in vitro, demonstrating E3 ligase activity of the RING domain(s). JMJ24-JmjC binds the N-terminal tail of histone H3, and full-length JMJ24 binds histone H3 in vivo. JMJ24 activity is anticorrelated with histone H3 Lys 9 dimethylation (H3K9me2) levels at AtMu1c. Double mutant analyses with epigenetic silencing mutants suggest that JMJ24 antagonizes histone H3K9me2 and requires H3K9 methyltransferases for its activity on AtMu1c. Genome-wide transcriptome analysis indicates that JMJ24 affects silencing at additional TEs. Our results suggest that the JmjC domain of JMJ24 has lost demethylase activity but has been retained as a binding domain for histone H3. This is in line with phylogenetic analyses indicating that JMJ24 (with the mutated JmjC domain) is widely conserved in angiosperms. Taken together, this study assigns a role in TE silencing to a conserved JmjC-domain protein with E3 ligase activity, but no demethylase activity.},
language = {en}
}
@article{CwiekKupczynskaAltmannArendetal.2016,
author = {´Cwiek-Kupczynska, Hanna and Altmann, Thomas and Arend, Daniel and Arnaud, Elizabeth and Chen, Dijun and Cornut, Guillaume and Fiorani, Fabio and Frohmberg, Wojciech and Junker, Astrid and Klukas, Christian and Lange, Matthias and Mazurek, Cezary and Nafissi, Anahita and Neveu, Pascal and van Oeveren, Jan and Pommier, Cyril and Poorter, Hendrik and Rocca-Serra, Philippe and Sansone, Susanna-Assunta and Scholz, Uwe and van Schriek, Marco and Seren, {\"U}mit and Usadel, Bjorn and Weise, Stephan and Kersey, Paul and Krajewski, Pawel},
title = {Measures for interoperability of phenotypic data: minimum information requirements and formatting},
series = {Plant Methods},
volume = {12},
journal = {Plant Methods},
publisher = {BioMed Central},
address = {London},
issn = {1746-4811},
doi = {10.1186/s13007-016-0144-4},
pages = {18},
year = {2016},
abstract = {Background: Plant phenotypic data shrouds a wealth of information which, when accurately analysed and linked to other data types, brings to light the knowledge about the mechanisms of life. As phenotyping is a field of research comprising manifold, diverse and time-consuming experiments, the findings can be fostered by reusing and combining existing datasets. Their correct interpretation, and thus replicability, comparability and interoperability, is possible provided that the collected observations are equipped with an adequate set of metadata. So far there have been no common standards governing phenotypic data description, which hampered data exchange and reuse. Results: In this paper we propose the guidelines for proper handling of the information about plant phenotyping experiments, in terms of both the recommended content of the description and its formatting. We provide a document called "Minimum Information About a Plant Phenotyping Experiment", which specifies what information about each experiment should be given, and a Phenotyping Configuration for the ISA-Tab format, which allows to practically organise this information within a dataset. We provide examples of ISA-Tab-formatted phenotypic data, and a general description of a few systems where the recommendations have been implemented. Conclusions: Acceptance of the rules described in this paper by the plant phenotyping community will help to achieve findable, accessible, interoperable and reusable data.},
language = {en}
}
@misc{HellingBergholzWalteretal.2004,
author = {Helling, Robert and Bergholz, Natalie and Walter, Kai and Bartram, Kristin and Humborg, Christian and Lieber, Silke and Armstrong, Stephen Andrew and Krotoschak, Kai-Uwe and Pohl, Franzisca and Wambsganß, Joachim and Gebhardt, Thomas},
title = {Portal alumni},
series = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
volume = {2004},
journal = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
number = {1},
organization = {Stabsstelle Studierendenmarketing/Alumniprogramm Im Auftrag der Pr{\"a}sidentin der Universit{\"a}t Potsdam},
doi = {10.25932/publishup-48098},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-480981},
pages = {58},
year = {2004},
abstract = {More than 800 alumni have expressed an interest in staying in touch with the University of Potsdam by registering for the Alumni Programme since it was launched in May 2003. Among them are many international alumni like you. Whether you were here as a student, doing research or were employed at the University of Potsdam, we hope that you enjoyed your time with us and that you have good memories of it. Today, you have opened the first edition of our new, annual alumni magazine. lt is another important part of our Alumni Pogramme that will provide you with regular news from your form er University. The main feature of this edition is "weit weg", far away. When making contact again with the University's alumni in May of 200J, we found out that alumni have been scattered to the winds - some of you are in Australia, Africa and America. We were curious to hear how those far away had managed the transition of moving to live abroad, and we also wanted to learn about their experiences on the way. Apart from lots of exciting stories and recommendations for others, you will find information on the issues of careers and mobility. And next to what alumni with an international profile have to say, you will also read about how professors of the University of Potsdam are working with their alumni at the moment, and what they are planning to do in the future. We regret not being able to publish this magazine bilingually. However; we have added abstracts in English to these articles, hoping to help you with your reading comprehension. Also, we have launched an English website for those of you who only read English. You will find it at www.alumni.uni-potsdam.de. The website gives general information, and you can read this magazine online.},
language = {de}
}
@article{KoshkinaLangThiermannetal.2015,
author = {Koshkina, Olga and Lang, Thomas and Thiermann, Raphael and Docter, Dominic and Stauber, Roland H. and Secker, Christian and Schlaad, Helmut and Weidner, Steffen and Mohr, Benjamin and Maskos, Michael and Bertin, Annabelle},
title = {Temperature-Triggered Protein Adsorption on Polymer-Coated Nanoparticles in Serum},
series = {Langmuir},
volume = {31},
journal = {Langmuir},
number = {32},
publisher = {American Chemical Society},
address = {Washington},
issn = {0743-7463},
doi = {10.1021/acs.langmuir.5b00537},
pages = {8873 -- 8881},
year = {2015},
abstract = {The protein corona, which forms on the nanoparticle's surface in most biological media, determines the nanoparticle's physicochemical characteristics. The formation of the protein corona has a significant impact on the biodistribution and clearance of nanoparticles in vivo. Therefore, the ability to influence the formation of the protein corona is essential to most biomedical applications, including drug delivery and imaging. In this study, we investigate the protein adsorption on nanoparticles with a hydrodynamic radius of 30 nm and a coating of thermoresponsive poly(2-isopropyl-2-oxazoline) in serum. Using multiangle dynamic light scattering (DLS) we demonstrate that heating of the nanoparticles above their phase separation temperature induces the formation of agglomerates, with a hydrodynamic radius of 1 mu m. In serum, noticeably stronger agglomeration occurs at lower temperatures compared to serum-free conditions. Cryogenic transmission electron microscopy (cryo-TEM) revealed a high packing density of agglomerates when serum was not present. In contrast, in the presence of serum, agglomerated nanoparticles were loosely packed, indicating that proteins are intercalated between them. Moreover, an increase in protein content is observed upon heating, confirming that protein adsorption is induced by the alteration of the surface during phase separation. After cooling and switching the surface back, most of the agglomerates were dissolved and the main fraction returned to the original size of approximately 30 nm as shown by asymmetrical flow-field flow fractionation (AF-FFF) and DLS. Furthermore, the amounts of adsorbed proteins are similar before and after heating the nanoparticles to above their phase-separation temperature. Overall, our results demonstrate that the thermoresponsivity of the polymer coating enables turning the corona formation on nanoparticles on and off in situ. As the local heating of body areas can be easily done in vivo, the thermoresponsive coating could potentially be used to induce the agglomeration of nanopartides and proteins and the accumulation of nanoparticles in a targeted body region.},
language = {en}
}
@article{KoshkinaWestmeierLangetal.2016,
author = {Koshkina, Olga and Westmeier, Dana and Lang, Thomas and Bantz, Christoph and Hahlbrock, Angelina and W{\"u}rth, Christian and Resch-Genger, Ute and Braun, Ulrike and Thiermann, Raphael and Weise, Christoph and Eravci, Murat and Mohr, Benjamin and Schlaad, Helmut and Stauber, Roland H. and Docter, Dominic and Bertin, Annabelle and Maskos, Michael},
title = {Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake},
series = {Macromolecular bioscience},
volume = {16},
journal = {Macromolecular bioscience},
publisher = {Wiley-VCH},
address = {Weinheim},
issn = {1616-5187},
doi = {10.1002/mabi.201600074},
pages = {1287 -- 1300},
year = {2016},
abstract = {Due to the adsorption of biomolecules, the control of the biodistribution of nanoparticles is still one of the major challenges of nanomedicine. Poly(2-ethyl-2-oxazoline) (PEtOx) for surface modification of nanoparticles is applied and both protein adsorption and cellular uptake of PEtOxylated nanoparticles versus nanoparticles coated with poly(ethylene glycol) (PEG) and non-coated positively and negatively charged nanoparticles are compared. Therefore, fluorescent poly(organosiloxane) nanoparticles of 15 nm radius are synthesized, which are used as a scaffold for surface modification in a grafting onto approach. With multi-angle dynamic light scattering, asymmetrical flow field-flow fractionation, gel electrophoresis, and liquid chromatography-mass spectrometry, it is demonstrated that protein adsorption on PEtOxylated nanoparticles is extremely low, similar as on PEGylated nanoparticles. Moreover, quantitative microscopy reveals that PEtOxylation significantly reduces the non-specific cellular uptake, particularly by macrophage-like cells. Collectively, studies demonstrate that PEtOx is a very effective alternative to PEG for stealth modification of the surface of nanoparticles.},
language = {en}
}
@article{WischkeBaehrRachevaetal.2018,
author = {Wischke, Christian and Baehr, Elen and Racheva, Miroslava and Heuchel, Matthias and Weigel, Thomas and Lendlein, Andreas},
title = {Surface immobilization strategies for tyrosinase as biocatalyst applicable to polymer network synthesis},
series = {MRS Advances},
volume = {3},
journal = {MRS Advances},
number = {63},
publisher = {Cambridge Univ. Press},
address = {New York},
issn = {2059-8521},
doi = {10.1557/adv.2018.630},
pages = {3875 -- 3881},
year = {2018},
abstract = {Enzymes have recently attracted increasing attention in material research based on their capacity to catalyze the conversion of polymer-bound moieties for synthesizing polymer networks, particularly bulk hydrogels. hi this study. the surface immobilization of a relevant enzyme. mushroom tyrosinase, should be explored using glass as model surface. In a first step. the glass support was functionalized with silanes to introduce either amine or carboxyl groups, as confirmed e.g. by X-ray photoelectron spectroscopy. By applying glutaraldehyde and EDC/NHS chemistry, respectively, surfaces have been activated for subsequent successful coupling of tyrosinase. Via protein hydrolysis and amino acid characterization by HPLC, the quantity of bound tyrosinase was shown to correspond to a full surface coverage. Based on the visualized enzymatic conversion of a test substrate at the glass support. the functionalized surfaces may be explored for surface-associated material synthesis in the future.},
language = {en}
}
@article{DebatinThomasKellingetal.2010,
author = {Debatin, Franziska and Thomas, Arne and Kelling, Alexandra and Hedin, Niklas and Bacsik, Zoltan and Senkovska, Irena and Kaskel, Stefan and Junginger, Matthias and M{\"u}ller, Holger and Schilde, Uwe and J{\"a}ger, Christian and Friedrich, Alwin and Holdt, Hans-J{\"u}rgen},
title = {In situ synthesis of an imidazolate-4-amide-5-imidate ligand and formation of a microporous zinc-organic framework with H2-and CO2-storage ability},
issn = {1433-7851},
doi = {10.1002/anie.200906188},
year = {2010},
abstract = {Narrow channels with polar walls are the structural and functional features responsible for the high capacity of a zinc-organic framework based on an imidazolate-amide-imidate ligand for the uptake of H2 and CO2 (see structure: orange Zn, blue N, red O, dark gray C, light gray H). The rigid and stable chelating ligand was synthesized in situ by partial hydrolysis of a dicyanoimidazole compound.},
language = {en}
}
@book{KloseNoldeEichholzetal.2008,
author = {Klose, Dagmar and Nolde, Bettina and Eichholz, Nicole and Nolde, Bettina and Engelland, Christian and Kroggel, Petra and Kunde, Christine and Pirska, Maya and St{\"a}hr, Anne and Flechsig, Thomas and Lehmann, Andrea and Petersen, Anne and Siekmann, Katja and Bielick, Jakob and Skerra, Arne and Bonnet, Florian and Klemmt, Gregor and Wagner, Anne and M{\"u}ller, Andreas and Schurmann, Angela},
title = {Die Grundlegung der modernen Welt in der Antike : Lehrerhandreiche f{\"u}r den Geschichtsunterricht nach neuem Rahmenlehrplan f{\"u}r die Sekundarstufe II Berlin-Brandenburg},
editor = {Klose, Dagmar},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
isbn = {978-3-939469-96-4},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-15298},
publisher = {Universit{\"a}t Potsdam},
pages = {291},
year = {2008},
abstract = {Ein neues Ziel-Inhalts-Konzept des Rahmenlehrplans nimmt in dieser Lehrerhandreiche Gestalt an. Fachwissenschaftliche und didaktische Instruktionen sowie ein ideenreicher Arbeitsteil (Materialien und Aufgaben) helfen bei der Unterrichtsvorbereitung. Aus dem Inhalt: - ein integratives Antike-Projekt untersucht M{\"o}glichkeiten und Grenzen gesellschaftlicher Teilhabe in Athen und der r{\"o}mischen Republik; - Augustus und Alexander als Zentralgestalten universaler Monarchie und Reichsbildung werden in der biografischen Rekonstruktion und im historischen Kontext lebendig; - das Thema Erinnerungskultur in der Antike und heute verweist auf Grundprobleme der Geschichtskultur; - Anregungen zur Arbeit mit dem Spielfilm „Alexander" als historische Quelle f{\"u}hren an rezeptionsgeschichtliche und medienspezifische Aspekte historischen Lernens heran},
language = {de}
}
@misc{MangelsdorfHornConradBagdahnetal.2011,
author = {Mangelsdorf, Birgit and Horn-Conrad, Antje and Bagdahn, Christian and Schmidt, Bernd and Eckardt, Barbara and G{\"o}rlich, Petra and Peter, Andreas and P{\"o}sl, Thomas and Nestler, Ralf and Zimmermann, Matthias},
title = {Portal = Wenn die Chemie stimmt: L{\"o}sungen f{\"u}r heute und morgen},
series = {Das Potsdamer Universit{\"a}tsmagazin},
journal = {Das Potsdamer Universit{\"a}tsmagazin},
number = {03/2011},
organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit},
issn = {1618-6893},
doi = {10.25932/publishup-45981},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-459810},
pages = {43},
year = {2011},
abstract = {Aus dem Inhalt: - Wenn die Chemie stimmt: L{\"o}sungen f{\"u}r heute und morgen - Das Kreuz mit dem Kreuz - „Das verr{\"u}ckteste Jahr unseres Lebens"},
language = {de}
}
@article{ScheffczykEngbertKrampeetal.1996,
author = {Scheffczyk, Christian and Engbert, Ralf and Krampe, Ralf-Thomas and Kurths, J{\"u}rgen and Rosenblum, Michael and Zaikin, Alexei A.},
title = {Nonlinear Modelling of Polyrhythmic Hand Movements},
year = {1996},
language = {en}
}
@article{HuberRiglingBebietal.2013,
author = {Huber, Robert and Rigling, Andreas and Bebi, Peter and Brand, Fridolin Simon and Briner, Simon and Buttler, Alexandre and Elkin, Che and Gillet, Francois and Gret-Regamey, Adrienne and Hirschi, Christian and Lischke, Heike and Scholz, Roland Werner and Seidl, Roman and Spiegelberger, Thomas and Walz, Ariane and Zimmermann, Willi and Bugmann, Harald},
title = {Sustainable land use in Mountain Regions under global change synthesis across scales and disciplines},
series = {Ecology and society : a journal of integrative science for resilience and sustainability},
volume = {18},
journal = {Ecology and society : a journal of integrative science for resilience and sustainability},
number = {3},
publisher = {Resilience Alliance},
address = {Wolfville},
issn = {1708-3087},
doi = {10.5751/ES-05499-180336},
pages = {20},
year = {2013},
abstract = {Mountain regions provide essential ecosystem goods and services (EGS) for both mountain dwellers and people living outside these areas. Global change endangers the capacity of mountain ecosystems to provide key services. The Mountland project focused on three case study regions in the Swiss Alps and aimed to propose land-use practices and alternative policy solutions to ensure the provision of key EGS under climate and land-use changes. We summarized and synthesized the results of the project and provide insights into the ecological, socioeconomic, and political processes relevant for analyzing global change impacts on a European mountain region. In Mountland, an integrative approach was applied, combining methods from economics and the political and natural sciences to analyze ecosystem functioning from a holistic human-environment system perspective. In general, surveys, experiments, and model results revealed that climate and socioeconomic changes are likely to increase the vulnerability of the EGS analyzed. We regard the following key characteristics of coupled human-environment systems as central to our case study areas in mountain regions: thresholds, heterogeneity, trade-offs, and feedback. Our results suggest that the institutional framework should be strengthened in a way that better addresses these characteristics, allowing for (1) more integrative approaches, (2) a more network-oriented management and steering of political processes that integrate local stakeholders, and (3) enhanced capacity building to decrease the identified vulnerability as central elements in the policy process. Further, to maintain and support the future provision of EGS in mountain regions, policy making should also focus on project-oriented, cross-sectoral policies and spatial planning as a coordination instrument for land use in general.},
language = {en}
}
@article{ChristianMayKempaetal.2009,
author = {Christian, Nils and May, Patrick and Kempa, Stefan and Handorf, Thomas and Ebenhoeh, Oliver},
title = {An integrative approach towards completing genome-scale metabolic networks},
issn = {1742-206X},
doi = {10.1039/B915913b},
year = {2009},
abstract = {Genome-scale metabolic networks which have been automatically derived through sequence comparison techniques are necessarily incomplete. We propose a strategy that incorporates genomic sequence data and metabolite profiles into modeling approaches to arrive at improved gene annotations and more complete genome-scale metabolic networks. The core of our strategy is an algorithm that computes minimal sets of reactions by which a draft network has to be extended in order to be consistent with experimental observations. A particular strength of our approach is that alternative possibilities are suggested and thus experimentally testable hypotheses are produced. We carefully evaluate our strategy on the well-studied metabolic network of Escherichia coli, demonstrating how the predictions can be improved by incorporating sequence data. Subsequently, we apply our method to the recently sequenced green alga Chlamydomonas reinhardtii. We suggest specific genes in the genome of Chlamydomonas which are the strongest candidates for coding the responsible enzymes.},
language = {en}
}
@article{MahapatraVetterZuhrtetal.1997,
author = {Mahapatra, Susanta and Vetter, Reinhard and Zuhrt, Christian and Nguyen, Huu Tong and Ritschel, Thomas and Z{\"u}licke, Lutz},
title = {Bound states and time-dependent dynamics of the N2H+ molecular ion in its ground electronic state. I. 2D treatment},
year = {1997},
language = {en}
}
@article{MahapatraZuhrtVetteretal.1996,
author = {Mahapatra, Susanta and Zuhrt, Christian and Vetter, Reinhard and Nguyen, Huu Tong and Ritschel, Thomas and Z{\"u}licke, Lutz},
title = {Spectroscopy and intramalocular dynamics of collinear N2H+ on a new potential energy surface},
series = {Technical Report / Institute of Physical and Theoretical Chemistry, Potsdam},
volume = {1996, 03},
journal = {Technical Report / Institute of Physical and Theoretical Chemistry, Potsdam},
publisher = {Univ.},
address = {Potsdam},
pages = {28, [8] S. : graph. Darst.},
year = {1996},
language = {en}
}
@article{BrendlerRiebeRitscheletal.2013,
author = {Brendler, Christian and Riebe, Daniel and Ritschel, Thomas and Beitz, Toralf and L{\"o}hmannsr{\"o}ben, Hans-Gerd},
title = {Investigation of neuroleptics and other aromatic compounds by laser-based ion mobility mass spectrometry},
series = {Analytical \& bioanalytical chemistry},
volume = {405},
journal = {Analytical \& bioanalytical chemistry},
number = {22},
publisher = {Springer},
address = {Heidelberg},
issn = {1618-2642},
doi = {10.1007/s00216-012-6654-7},
pages = {7019 -- 7029},
year = {2013},
abstract = {Laser-based ion mobility (IM) spectrometry was used for the detection of neuroleptics and PAH. A gas chromatograph was connected to the IM spectrometer in order to investigate compounds with low vapour pressure. The substances were ionized by resonant two-photon ionization at the wavelengths lambda = 213 and 266 nm and pulse energies between 50 and 300 mu J. Ion mobilities, linear ranges, limits of detection and response factors are reported. Limits of detection for the substances are in the range of 1-50 fmol. Additionally, the mechanism of laser ionization at atmospheric pressure was investigated. First, the primary product ions were determined by a laser-based time-of-flight mass spectrometer with effusive sample introduction. Then, a combination of a laser-based IM spectrometer and an ion trap mass spectrometer was developed and characterized to elucidate secondary ion-molecule reactions that can occur at atmospheric pressure. Some substances, namely naphthalene, anthracene, promazine and thioridazine, could be detected as primary ions (radical cations), while other substances, in particular acridine, phenothiazine and chlorprothixene, are detected as secondary ions (protonated molecules). The results are interpreted on the basis of quantum chemical calculations, and an ionization mechanism is proposed.},
language = {en}
}
@article{JedrusikBodeStudenckaSmolkaetal.2013,
author = {Jedrusik-Bode, Monika and Studencka, Maja and Smolka, Christian and Baumann, Tobias and Schmidt, Henning and Kampf, Jan and Paap, Franziska and Martin, Sophie and Tazi, Jamal and M{\"u}ller, Kristian M. and Kr{\"u}ger, Marcus and Braun, Thomas and Bober, Eva},
title = {The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals},
series = {Journal of cell science},
volume = {126},
journal = {Journal of cell science},
number = {22},
publisher = {Company of Biologists Limited},
address = {Cambridge},
issn = {0021-9533},
doi = {10.1242/jcs.130708},
pages = {5166 -- +},
year = {2013},
abstract = {SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.},
language = {en}
}
@article{StrefferKaatzBaueretal.1998,
author = {Streffer, Katrin and Kaatz, Helvi and Bauer, Christian G. and Makower, Alexander and Schulmeister, Thomas and Scheller, Frieder W. and Peter, Martin G. and Wollenberger, Ursula},
title = {Application of a sensitive catechol detector for determination of tyrosinase inhibitors},
year = {1998},
language = {en}
}
@article{MahapatraVetterZuhrtetal.1998,
author = {Mahapatra, Susanta and Vetter, Reinhard and Zuhrt, Christian and Nguyen, Huu Tong and Ritschel, Thomas and Z{\"u}licke, Lutz},
title = {Ground state potential energy surface, 3D time-dependent intramolecular dynamics and vibrational states of the N2H+ molecular ion},
year = {1998},
language = {en}
}
@article{ZaikinRosenblumScheffczyketal.1997,
author = {Zaikin, Alexei A. and Rosenblum, Michael and Scheffczyk, Christian and Engbert, Ralf and Krampe, Ralf-Thomas and Kurths, J{\"u}rgen},
title = {Modeling qualitative changes in bimanual movements},
year = {1997},
language = {en}
}
@inproceedings{PamiesBresslerZhangetal.2014,
author = {Pamies, David and Bressler, Joshep and Zhang, Ce and Palma-Lima, Marina and Christian, Kimberly M. and Sminrnova, Lena and Harris, Georgina and Block, Katharina and Hartung, Thomas and Hogberg, Helena},
title = {Personalized microphysiological system of the brain to study gene/environment interactions},
series = {Toxicology letters},
volume = {229},
booktitle = {Toxicology letters},
publisher = {Elsevier},
address = {Clare},
issn = {0378-4274},
doi = {10.1016/j.toxlet.2014.06.202},
pages = {S46 -- S47},
year = {2014},
language = {en}
}
@misc{KisslingDormannGroeneveldetal.2012,
author = {Kissling, W. D. and Dormann, Carsten F. and Groeneveld, Juergen and Hickler, Thomas and K{\"u}hn, Ingolf and McInerny, Greg J. and Montoya, Jose M. and R{\"o}mermann, Christine and Schiffers, Katja and Schurr, Frank Martin and Singer, Alexander and Svenning, Jens-Christian and Zimmermann, Niklaus E. and O'Hara, Robert B.},
title = {Towards novel approaches to modelling biotic interactions in multispecies assemblages at large spatial extents},
series = {Journal of biogeography},
volume = {39},
journal = {Journal of biogeography},
number = {12},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {0305-0270},
doi = {10.1111/j.1365-2699.2011.02663.x},
pages = {2163 -- 2178},
year = {2012},
abstract = {Aim Biotic interactions within guilds or across trophic levels have widely been ignored in species distribution models (SDMs). This synthesis outlines the development of species interaction distribution models (SIDMs), which aim to incorporate multispecies interactions at large spatial extents using interaction matrices. Location Local to global. Methods We review recent approaches for extending classical SDMs to incorporate biotic interactions, and identify some methodological and conceptual limitations. To illustrate possible directions for conceptual advancement we explore three principal ways of modelling multispecies interactions using interaction matrices: simple qualitative linkages between species, quantitative interaction coefficients reflecting interaction strengths, and interactions mediated by interaction currencies. We explain methodological advancements for static interaction data and multispecies time series, and outline methods to reduce complexity when modelling multispecies interactions. Results Classical SDMs ignore biotic interactions and recent SDM extensions only include the unidirectional influence of one or a few species. However, novel methods using error matrices in multivariate regression models allow interactions between multiple species to be modelled explicitly with spatial co-occurrence data. If time series are available, multivariate versions of population dynamic models can be applied that account for the effects and relative importance of species interactions and environmental drivers. These methods need to be extended by incorporating the non-stationarity in interaction coefficients across space and time, and are challenged by the limited empirical knowledge on spatio-temporal variation in the existence and strength of species interactions. Model complexity may be reduced by: (1) using prior ecological knowledge to set a subset of interaction coefficients to zero, (2) modelling guilds and functional groups rather than individual species, and (3) modelling interaction currencies and species effect and response traits. Main conclusions There is great potential for developing novel approaches that incorporate multispecies interactions into the projection of species distributions and community structure at large spatial extents. Progress can be made by: (1) developing statistical models with interaction matrices for multispecies co-occurrence datasets across large-scale environmental gradients, (2) testing the potential and limitations of methods for complexity reduction, and (3) sampling and monitoring comprehensive spatio-temporal data on biotic interactions in multispecies communities.},
language = {en}
}
@article{JersabekWeithoffWeisse2011,
author = {Jersabek, Christian D. and Weithoff, Guntram and Weisse, Thomas},
title = {Cephalodella acidophila n. sp (Monogononta: Notommatidae), a new rotifer species from highly acidic mining lakes},
series = {Zootaxa : an international journal of zootaxonomy ; a rapid international journal for animal taxonomists},
journal = {Zootaxa : an international journal of zootaxonomy ; a rapid international journal for animal taxonomists},
number = {2939},
publisher = {Magnolia Press},
address = {Auckland},
issn = {1175-5326},
pages = {50 -- 58},
year = {2011},
abstract = {We describe a new species of Cephalodella, C. acidophila n. sp., from the plankton of two extremely acidic mining lakes (pH <3) in Austria and Germany. The species is morphologically closely related to Cephalodella delicata Wulfert. It shares with the latter an almost identical trophi morphology and anatomical organization, but differs clearly by form and length of its toes, larger body size, and ecology. Laboratory experiments revealed that the species is acidophilic, i.e. it thrives at low pH (<4) and does not survive at circumneutral conditions. The species occurs in man-made habitats at low to moderate abundance (usually 5-22 individuals l(-1)) and in stock cultures thrives on the green alga Chlamydomonas acidophila. The easily cultured species has previously been used in various experimental studies, but has only now been recognized as an undescribed species.},
language = {en}
}
@article{ThuillerMuenkemuellerSchiffersetal.2014,
author = {Thuiller, Wilfried and Muenkemueller, Tamara and Schiffers, Katja H. and Georges, Damien and Dullinger, Stefan and Eckhart, Vincent M. and Edwards, Thomas C. and Gravel, Dominique and Kunstler, Georges and Merow, Cory and Moore, Kara and Piedallu, Christian and Vissault, Steve and Zimmermann, Niklaus E. and Zurell, Damaris and Schurr, Frank Martin},
title = {Does probability of occurrence relate to population dynamics?},
series = {Ecography : pattern and diversity in ecology ; research papers forum},
volume = {37},
journal = {Ecography : pattern and diversity in ecology ; research papers forum},
number = {12},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {0906-7590},
doi = {10.1111/ecog.00836},
pages = {1155 -- 1166},
year = {2014},
abstract = {Interestingly, relationships between demographic parameters and occurrence probability did not vary substantially across degrees of shade tolerance and regions. Although they were influenced by the uncertainty in the estimation of the demographic parameters, we found that r was generally negatively correlated with P-occ, while N, and for most regions K, was generally positively correlated with P-occ. Thus, in temperate forest trees the regions of highest occurrence probability are those with high densities but slow intrinsic population growth rates. The uncertain relationships between demography and occurrence probability suggests caution when linking species distribution and demographic models.},
language = {en}
}
@article{HahnEngelhardReschkeetal.2015,
author = {Hahn, Aaron and Engelhard, Christopher and Reschke, Stefan and Teutloff, Christian and Bittl, Robert and Leimk{\"u}hler, Silke and Risse, Thomas},
title = {Structural Insights into the Incorporation of the Mo Cofactor into Sulfite Oxidase from Site-Directed Spin Labeling},
series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition},
volume = {54},
journal = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition},
number = {40},
publisher = {Wiley-VCH},
address = {Weinheim},
issn = {1433-7851},
doi = {10.1002/anie.201504772},
pages = {11865 -- 11869},
year = {2015},
abstract = {Mononuclear molybdoenzymes catalyze a broad range of redox reactions and are highly conserved in all kingdoms of life. This study addresses the question of how the Mo cofactor (Moco) is incorporated into the apo form of human sulfite oxidase (hSO) by using site-directed spin labeling to determine intramolecular distances in the nanometer range. Comparative measurements of the holo and apo forms of hSO enabled the localization of the corresponding structural changes, which are localized to a short loop (residues 263-273) of the Moco-containing domain. A flap-like movement of the loop provides access to the Moco binding-pocket in the apo form of the protein and explains the earlier studies on the in vitro reconstitution of apo-hSO with Moco. Remarkably, the loop motif can be found in a variety of structurally similar molybdoenzymes among various organisms, thus suggesting a common mechanism of Moco incorporation.},
language = {en}
}
@article{HeneghanWardPereraetal.2012,
author = {Heneghan, Carl and Ward, Alison and Perera, Rafael and Bankhead, Clare and Fuller, Alice and Stevens, Richard and Bradford, Kairen and Tyndel, Sally and Alonso-Coello, Pablo and Ansell, Jack and Beyth, Rebecca and Bernardo, Artur and Christensen, Thomas Decker and Cromheecke, Manon and Edson, Robert G and Fitzmaurice, David and Gadisseur, Alain PA and Garcia-Alamino, Josep M and Gardiner, Chris and Hasenkam, Michael and Jacobson, Alan and Kaatz, Scott and Kamali, Farhad and Khan, Tayyaba Irfan and Knight, Eve and Kortke, Heinrich and Levi, Marcel and Matchar, David Bruce and Menendez-Jandula, Barbara and Rakovac, Ivo and Schaefer, Christian and Siebenhofer, Andrea and Souto, Juan Carlos and Sunderji, Rubina and Gin, Kenneth and Shalansky, Karen and V{\"o}ller, Heinz and Wagner, Otto and Zittermann, Armin},
title = {Self-monitoring of oral anticoagulation systematic review and meta-analysis of individual patient data},
series = {The lancet},
volume = {379},
journal = {The lancet},
number = {9813},
publisher = {Elsevier},
address = {New York},
organization = {Self-Monitoring Trialist Collabora},
issn = {0140-6736},
doi = {10.1016/S0140-6736(11)61294-4},
pages = {322 -- 334},
year = {2012},
abstract = {Background Uptake of self-testing and self-management of oral coagulation has remained inconsistent, despite good evidence of their effectiveness. To clarify the value of self-monitoring of oral anticoagulation, we did a meta-analysis of individual patient data addressing several important gaps in the evidence, including an estimate of the effect on time to death, first major haemorrhage, and thromboembolism. Methods We searched Ovid versions of Embase (1980-2009) and Medline (1966-2009), limiting searches to randomised trials with a maximally sensitive strategy. We approached all authors of included trials and requested individual patient data: primary outcomes were time to death, first major haemorrhage, and first thromboembolic event. We did prespecified subgroup analyses according to age, type of control-group care (anticoagulation-clinic care vs primary care), self-testing alone versus self-management, and sex. We analysed patients with mechanical heart valves or atrial fibrillation separately. We used a random-effect model method to calculate pooled hazard ratios and did tests for interaction and heterogeneity, and calculated a time-specific number needed to treat. Findings Of 1357 abstracts, we included 11 trials with data for 6417 participants and 12 800 person-years of follow-up. We reported a significant reduction in thromboembolic events in the self-monitoring group (hazard ratio 0.51; 95\% CI 0.31-0.85) but not for major haemorrhagic events (0.88, 0.74-1.06) or death (0.82, 0.62-1.09). Participants younger than 55 years showed a striking reduction in thrombotic events (hazard ratio 0.33, 95\% CI 0.17-0.66), as did participants with mechanical heart valve (0.52, 0.35-0.77). Analysis of major outcomes in the very elderly (age >= 85 years, n=99) showed no significant adverse effects of the intervention for all outcomes. Interpretation Our analysis showed that self-monitoring and self-management of oral coagulation is a safe option for suitable patients of all ages. Patients should also be offered the option to self-manage their disease with suitable health-care support as back-up.},
language = {en}
}
@article{RybergHaberlandHaberlauetal.2015,
author = {Ryberg, Trond and Haberland, Christian and Haberlau, Thomas and Weber, Michael H. and Bauer, Klaus and Behrmann, Jan H. and Jokat, Wilfried},
title = {Crustal structure of northwest Namibia: Evidence for plume-rift-continent interaction},
series = {Geology},
volume = {43},
journal = {Geology},
number = {8},
publisher = {American Institute of Physics},
address = {Boulder},
issn = {0091-7613},
doi = {10.1130/G36768.1},
pages = {739 -- 742},
year = {2015},
abstract = {The causes for the formation of large igneous provinces and hotspot trails are still a matter of considerable dispute. Seismic tomography and other studies suggest that hot mantle material rising from the core-mantle boundary (CMB) might play a significant role in the formation of such hotspot trails. An important area to verify this concept is the South Atlantic region, with hotspot trails that spatially coincide with one of the largest low-velocity regions at the CMB, the African large low shear-wave velocity province. The Walvis Ridge started to form during the separation of the South American and African continents at ca. 130 Ma as a consequence of Gondwana breakup. Here, we present the first deep-seismic sounding images of the crustal structure from the landfall area of the Walvis Ridge at the Namibian coast to constrain processes of plume-lithosphere interaction and the formation of continental flood basalts (Parana and Etendeka continental flood basalts) and associated intrusive rocks. Our study identified a narrow region (<100 km) of high-seismic-velocity anomalies in the middle and lower crust, which we interpret as a massive mafic intrusion into the northern Namibian continental crust. Seismic crustal reflection imaging shows a flat Moho as well as reflectors connecting the high-velocity body with shallow crustal structures that we speculate to mark potential feeder channels of the Etendeka continental flood basalt. We suggest that the observed massive but localized mafic intrusion into the lower crust results from similar-sized variations in the lithosphere (i.e., lithosphere thickness or preexisting structures).},
language = {en}
}
@article{StanislasHuserBarbosaetal.2015,
author = {Stanislas, Thomas and Huser, Anke and Barbosa, Ines C. R. and Kiefer, Christian S. and Brackmann, Klaus and Pietra, Stefano and Gustavsson, Anna and Zourelidou, Melina and Schwechheimer, Claus and Grebe, Markus},
title = {Arabidopsis D6PK is a lipid domain-dependent mediator of root epidermal planar polarity},
series = {Nature plants},
volume = {1},
journal = {Nature plants},
number = {11},
publisher = {Nature Publ. Group},
address = {London},
issn = {2055-026X},
doi = {10.1038/NPLANTS.2015.162},
pages = {9},
year = {2015},
abstract = {Development of diverse multicellular organisms relies on coordination of single-cell polarities within the plane of the tissue layer (planar polarity). Cell polarity often involves plasma membrane heterogeneity generated by accumulation of specific lipids and proteins into membrane subdomains. Coordinated hair positioning along Arabidopsis root epidermal cells provides a planar polarity model in plants, but knowledge about the functions of proteo-lipid domains in planar polarity signalling remains limited. Here we show that Rho-of-plant (ROP) 2 and 6, phosphatidylinositol-4-phosphate 5-kinase 3 (PIP5K3), DYNAMIN-RELATED PROTEIN (DRP) 1A and DRP2B accumulate in a sterol-enriched, polar membrane domain during root hair initiation. DRP1A, DRP2B, PIP5K3 and sterols are required for planar polarity and the AGCVIII kinase D6 PROTEIN KINASE (D6PK) is a modulator of this process. D6PK undergoes phosphatidylinositol-4,5-bisphosphate- and sterol-dependent basal-to-planar polarity switching into the polar, lipid-enriched domain just before hair formation, unravelling lipid-dependent D6PK localization during late planar polarity signalling.},
language = {en}
}
@article{FritzTagleAshworthetal.2016,
author = {Fritz, Joerg and Tagle, Roald and Ashworth, Luisa and Schmitt, Ralf Thomas and Hofmann, Axel and Luais, Beatrice and Harris, Phillip D. and Hoehnel, Desiree and {\"O}zdemir, Seda and Mohr-Westheide, Tanja and Koeberl, Christian},
title = {Nondestructive spectroscopic and petrochemical investigations of Paleoarchean spherule layers from the ICDP drill core BARB5, Barberton Mountain Land, South Africa},
series = {Quaestiones geographicae},
volume = {51},
journal = {Quaestiones geographicae},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {1086-9379},
doi = {10.1111/maps.12736},
pages = {2441 -- 2458},
year = {2016},
abstract = {A Paleoarchean impact spherule-bearing interval of the 763 m long International Continental Scientific Drilling Program (ICDP) drill core BARB5 from the lower Mapepe Formation of the Fig Tree Group, Barberton Mountain Land (South Africa) was investigated using nondestructive analytical techniques. The results of visual observation, infrared (IR) spectroscopic imaging, and micro-X-ray fluorescence (lXRF) of drill cores are presented. Petrographic and sedimentary features, as well as major and trace element compositions of lithologies from the micrometer to kilometer-scale, assisted in the localization and characterization of eight spherule-bearing intervals between 512.6 and 510.5 m depth. The spherule layers occur in a strongly deformed section between 517 and 503 m, and the rocks in the core above and below are clearly less disturbed. The lXRF element maps show that spherule layers have similar petrographic and geochemical characteristics but differences in (1) sorting of two types of spherules and (2) occurrence of primary minerals (Ni-Cr spinel and zircon). We favor a single impact scenario followed by postimpact reworking, and subsequent alteration. The spherule layers are Al2O3-rich and can be distinguished from the Al2O3-poor marine sediments by distinct Al-OH absorption features in the short wave infrared (SWIR) region of the electromagnetic spectrum. Infrared images can cover tens to hundreds of square meters of lithologies and, thus, may be used to search for Al-OH-rich spherule layers in Al2O3-poor sediments, such as Eoarchean metasediments, where the textural characteristics of the spherule layers are obscured by metamorphism.},
language = {en}
}
@article{FriedlRengerBerlepschetal.2016,
author = {Friedl, Christian and Renger, Thomas and Berlepsch, Hans V. and Ludwig, Kai and Schmidt am Busch, Marcel and Megow, J{\"o}rg},
title = {Structure Prediction of Self-Assembled Dye Aggregates from Cryogenic Transmission Electron Microscopy, Molecular Mechanics, and Theory of Optical Spectra},
series = {The journal of physical chemistry : C, Nanomaterials and interfaces},
volume = {120},
journal = {The journal of physical chemistry : C, Nanomaterials and interfaces},
publisher = {American Chemical Society},
address = {Washington},
issn = {1932-7447},
doi = {10.1021/acs.jpcc.6b05856},
pages = {19416 -- 19433},
year = {2016},
abstract = {Cryogenic transmission electron microscopy (cryo-TEM) studies suggest that TTBC molecules self-assemble in aqueous solution to form single-walled tubes with a diameter of about 35 A. In order to reveal the arrangement and mutual orientations of the individual molecules in the tube, we combine information from crystal structure data of this dye with a calculation of linear absorbance and linear dichroism spectra and molecular dynamics simulations. We start with wrapping crystal planes in different directions to obtain tubes of suitable diameter. This set of tube models is evaluated by comparing the resulting optical spectra with experimental data. The tubes that can explain the spectra are investigated further by molecular dynamics simulations, including explicit solvent molecules. From the trajectories of the most stable tube models, the short-range ordering of the dye molecules is extracted and the optimization of the structure is iteratively completed. The final structural model is a tube of rings with 6-fold rotational symmetry, where neighboring rings are rotated by 30 and the-transition dipole moments of the chromophores form an angle of 74 with respect to the symmetry axis of the tube. This model is in agreement with cryo-TEM images and can explain the optical spectra, consisting of a sharp red-shifted J-band that is polarized parallel to to the symmetry axis of the tube and a broad blue-shifted H-band polarized perpendicular to this axis. The general structure of the homogeneous spectrum of this hybrid HJ-aggregate is described by an analytical model that explains the difference in redistribution of oscillator strength inside the vibrational manifolds of the J- and H-bands and the relative intensities and excitation energies of those bands. In addition to the-particular system investigated here, the present methodology can be expected to aid the structure prediction for a wide range of self-assembled dye aggregates.},
language = {en}
}
@article{EdlichMuthMurayaAltmannetal.2016,
author = {Edlich-Muth, Christian and Muraya, Moses M. and Altmann, Thomas and Selbig, Joachim},
title = {Phenomic prediction of maize hybrids},
series = {Biosystems : journal of biological and information processing sciences},
volume = {146},
journal = {Biosystems : journal of biological and information processing sciences},
publisher = {Elsevier},
address = {Oxford},
issn = {0303-2647},
doi = {10.1016/j.biosystems.2016.05.008},
pages = {102 -- 109},
year = {2016},
abstract = {Phenomic experiments are carried out in large-scale plant phenotyping facilities that acquire a large number of pictures of hundreds of plants simultaneously. With the aid of automated image processing, the data are converted into genotype-feature matrices that cover many consecutive days of development. Here, we explore the possibility of predicting the biomass of the fully grown plant from early developmental stage image-derived features. We performed phenomic experiments on 195 inbred and 382 hybrid maizes varieties and followed their progress from 16 days after sowing (DAS) to 48 DAS with 129 image-derived features. By applying sparse regression methods, we show that 73\% of the variance in hybrid fresh weight of fully-grown plants is explained by about 20 features at the three-leaf-stage or earlier. Dry weight prediction explained over 90\% of the variance. When phenomic features of parental inbred lines were used as predictors of hybrid biomass, the proportion of variance explained was 42 and 45\%, for fresh weight and dry weight models consisting of 35 and 36 features, respectively. These models were very robust, showing only a small amount of variation in performance over the time scale of the experiment. We also examined mid-parent heterosis in phenomic features. Feature heterosis displayed a large degree of variance which resulted in prediction performance that was less robust than models of either parental or hybrid predictors. Our results show that phenomic prediction is a viable alternative to genomic and metabolic prediction of hybrid performance. In particular, the utility of early-stage parental lines is very encouraging. (C) 2016 Elsevier Ireland Ltd. All rights reserved.},
language = {en}
}
@article{KieferClaesNzayisengaetal.2015,
author = {Kiefer, Christian S. and Claes, Andrea R. and Nzayisenga, Jean-Claude and Pietra, Stefano and Stanislas, Thomas and Hueser, Anke and Ikeda, Yoshihisa and Grebe, Markus},
title = {Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity},
series = {Development : Company of Biologists},
volume = {142},
journal = {Development : Company of Biologists},
number = {1},
publisher = {Company of Biologists Limited},
address = {Cambridge},
issn = {0950-1991},
doi = {10.1242/dev.111013},
pages = {151 -- 161},
year = {2015},
abstract = {The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.},
language = {en}
}
@article{AngerKonczakLinke2002,
author = {Anger, Christian and Konczak, Kathrin and Linke, Thomas},
title = {NoMoRe: Non-monotonic reasoning with logic programs},
isbn = {3-540-44190-5},
year = {2002},
language = {en}
}
@article{LinkeAngerKonczak2002,
author = {Linke, Thomas and Anger, Christian and Konczak, Kathrin},
title = {More on nomore},
year = {2002},
language = {en}
}
@article{PoloucekPietschGeueetal.2001,
author = {Poloucek, P. and Pietsch, Ullrich and Geue, Thomas and Symietz, Christian and Brezesinski, Gerald},
title = {X-ray reflectivity analysis of thin complex Langmuir-Blodgett films},
year = {2001},
language = {en}
}
@article{PietschGrenzerGeueetal.2001,
author = {Pietsch, Ullrich and Grenzer, J{\"o}rg and Geue, Thomas and Neißendorfer, Frank and Brezesinski, Gerald and Symietz, Christian and M{\"o}hwald, Helmuth and Gudat, Wolfgang},
title = {The energy dispersive reflectometer at BESSY II : a challenge for thin film analysis},
issn = {0167- 5087},
year = {2001},
language = {en}
}
@article{AngerKonczakLinke2001,
author = {Anger, Christian and Konczak, Kathrin and Linke, Thomas},
title = {A system for non-monotonic reasoning under answer set semantics},
isbn = {3-540-42593-4},
year = {2001},
language = {en}
}
@article{SchroederWarloHerrmannetal.1999,
author = {Schr{\"o}der, Rolf and Warlo, Irene and Herrmann, Harald and VanDerVen, Peter F. M and Klasen, Christian and Bl{\"u}mke, Ingmar and Mundegar, Rustam R. and F{\"u}rst, Dieter Oswald and G{\"o}bel, Hans H. and Magin, Thomas},
title = {Immunogold EM reveals a close association of plectin and the desmin cytoskeleton in human skeletal muscle},
year = {1999},
language = {en}
}
@article{ThomasLietz2019,
author = {Thomas, Linda and Lietz, Christian},
title = {Maßnahmen zur Erh{\"o}hung der Sichtbarkeit des wissenschaftlichen Outputs},
series = {Bibliotheksdienst},
volume = {53},
journal = {Bibliotheksdienst},
number = {5},
publisher = {de Gruyter},
address = {Berlin},
issn = {0006-1972},
doi = {10.1515/bd-2019-0040},
pages = {11},
year = {2019},
abstract = {Die Universit{\"a}t Potsdam hat 2018 zum zweiten Mal erfolgreich am Times Higher Education-Ranking (THE-Ranking) teilgenommen. Hierf{\"u}r wurde erneut das Publikationsaufkommen inklusive der Verbreitung der IDs von Autorinnen und Autoren, wie bspw. ORCiD, Researcher-ID oder Google Scholar-ID, ermittelt. Die aus den Erkenntnissen der ersten bibliometrischen Output-Analyse abgeleiteten Maßnahmen wurden nun hinsichtlich ihrer Wirksamkeit beurteilt. Der vorliegende Artikel vergleicht die Ergebnisse beider Analysen und thematisiert die Entwicklungen und Implikationen seit dem Ergreifen der ersten Maßnahmen.},
language = {de}
}
@book{AbelBerknerBiemeretal.2009,
author = {Abel, Thomas and Berkner, Christian and Biemer, Anna-Lena and Entz, Pamela and Hundt, Manuel and Kiener, Kerstin and Kiselgof, Natalia and K{\"o}hler, Anne and K{\"u}gler, Nancy and Lehmann, Anja and Liu, Na and Maier, Lilli and M{\"o}llmann, Nicole and Popig, Katharina and Reyes Tinoco, Bettina and Schmeißer, Alfred and Schr{\"o}ter, Katrin and Sturm, S{\"o}ren and Weichenhan, Marcel},
title = {Neuseeland 2007 : Bericht zur Exkursion des Instituts f{\"u}r Geographie der Universit{\"a}t Potsdam},
editor = {Berkner, Christian and Hundt, Manuel and Heller, Wilfried},
isbn = {978-3-940793-90-4},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32533},
publisher = {Universit{\"a}t Potsdam},
year = {2009},
abstract = {Im Februar und M{\"a}rz 2007 wurde vom Geographischen Institut der Universit{\"a}t eine Exkursion nach Neuseeland durchgef{\"u}hrt. Der hier vorliegende Bericht bezieht sich auf diese Exkursion. Im ersten Teil wird durch 17 Protokolle der Exkursionsverlauf wiedergegeben. Im zweiten Teil befassen sich sechs Texte n{\"a}her mit je einem thematischen Aspekt der Exkursion. Autoren der Protokolle und der thematischen Texte sind die Teilnehmerinnen und Teilnehmer der Exkursion. Zum ersten Teil des Berichts - der Exkursionsverlauf Im ersten Teil dieses Berichtes wird der Verlauf der Exkursion Neuseeland 2007 des Geographischen Instituts der Universit{\"a}t Potsdam durch Tagesprotokolle dargestellt. Die Exkursion begann am 14. Februar 2007 in Auckland und endete am 4. M{\"a}rz 2007 in Christchurch. W{\"a}hrend dieser 19 Tage wurden verschiedene Orte auf der neuseel{\"a}ndischen Nord- und S{\"u}dinsel aufgesucht, wobei die Exkursionsgruppe verschiedene Aspekte der neuseel{\"a}ndischen Gesellschaft aus einer humangeographischen Perspektive studierte. Im Mittelpunkt standen die Themen historische und j{\"u}ngere Migration nach Neuseeland, Maori, Milchwirtschaft, Holzwirtschaft und Tourismus in Neuseeland. Die Tagesprotokolle machen deutlich, dass die Exkursion weniger in einer thematisch-systematischen Art und Weise durchgef{\"u}hrt wurde. Statt dessen erfolgte das Aufsuchen exemplarischer Orte, an denen Beobachtungen und dar{\"u}ber hinausgehende Erkundungen stattfanden. Die entsprechenden Aussagen sind in den Protokollen wiedergegeben, schwerpunktm{\"a}ßig wird dabei folgendes angesprochen: Der erste Exkursionstag, das war der 14. Februar 2007, wurde f{\"u}r den Besuch des Geographischen Institutes der Auckland University genutzt. Dort wurde zum Beispiel eine Diskussionsrunde mit den beiden Humangeographen Richard Le Heron und Gordon Winder veranstaltet. Auch die folgenden zwei Tage verbrachten die Exkursionsgruppe in Auckland, wobei sie sich im »Auckland Museum« {\"u}ber die neuseel{\"a}ndische Geschichte und insbesondere {\"u}ber die Kultur der Maori informierte. Mit einem Maori-Guide unternahmen die Teilnehmer eine Stadtf{\"u}hrung durch Auckland, wobei ebenfalls das Leben der Maori im Fokus stand. Außerdem besuchten sie eine private Einwanderungsagentur und f{\"u}hrten in Kleingruppen Expertengespr{\"a}che zum Thema »Migration und Integration in Neuseeland« durch. Am 17. Februar erkundeten die Exkursionsteilnehmer drei Orte in der n{\"a}heren Umgebung Aucklands. Zun{\"a}chst begaben sie sich zum Otara Market, einem Wochenmarkt der Pacific Islanders, der immer samstags in Otara abgehalten wird. Anschließend ging es weiter an die westliche K{\"u}ste, wo sie unter F{\"u}hrung einer Rangerin durch den Muriwai-Regionalpark wanderten. Auf der R{\"u}ckfahrt nach Auckland machten sie Halt in Soljan's Winzerei, wo der Betrieb vorgestellt wurde und Wein verkosten werden konnte. Am 18. Februar verließ die Exkursionsgruppe Auckland in Richtung Norden, um zum Ort Puhoi zu gelangen. Dort besch{\"a}ftigten sich die Teilnehmer mit den sogenannten Bohemians, die einst aus B{\"o}hmen nach Neuseeland auswanderten und deren Traditionen dort auch heute noch (zumindest teilweise) gepflegt werden. Am n{\"a}chsten Tag fuhren sie weiter nach Pahia, dem n{\"o}rdlichsten Aufenthaltsort w{\"a}hrend der Exkursion. Auf dem Weg dorthin machten sie einen Umweg {\"u}ber Matakohe, wo das Kauri-Museum und der Tane Mahuta, der gr{\"o}ßte Kauribaum Neuseelands, besichtigt wurden. Am 20. Februar stand vormittags die Besch{\"a}ftigung mit der Geschichte Neuseelands auf dem Tagesplan. Hierf{\"u}r besuchte die Exkursionsgruppe die Waitangi Treaty Grounds. Dort informierten sich die Teilnehmer {\"u}ber den Vertrag von Waitangi und dar{\"u}ber, welche Folgen dieser f{\"u}r das Leben der Maori hatte. Am Nachmittag stand das Thema Tourismus im Mittelpunkt. Die Exkursionsteilnehmer machten sich mit einem Teil des touristischen Angebots vertraut, indem sie eine Bootstour durch die Bay of Islands unternahmen. Am 21. Februar fuhr die Gruppe in die Hamilton-Region, wo sie sich auch die folgenden zwei Tage aufhielt. Auf dem Weg dorthin wurde ein Zwischenstopp in Kawakawa und an den Whangarei Falls eingelegt. In Hamilton war die Exkursionsgruppe Gast im Geographischen Institut der Waikato University und im Waikato Migrant Resource Centre. Außerdem stand das Thema Milchwirtschaft auf dem Programm. Hierf{\"u}r besichtigten die Teilnehmer das Unternehmen AmBreed, welches die Grundlage f{\"u}r die Aufzucht von Hochleistungsmilchk{\"u}hen bereitstellt - n{\"a}mlich das Bullensperma. Außerdem konnten sie sich {\"u}ber die Organisation und Probleme einer Milchfarm informieren. Dar{\"u}ber hinaus gestalteten in der Waikato-Region wohnende Nachfahren der b{\"o}hmischen Einwanderer ein Abendprogramm f{\"u}r die Exkursionsgruppe. Den 24. Februar verbrachten die Teilnehmer im Gebiet von Rotorua. Dort durchkreuzten sie das Thermal Wonderland, in dem heiße Quellen und Geysire sowie die dadurch geschaffenen Oberfl{\"a}chengegebenheiten studiert werden k{\"o}nnen. Die heißen Quellen werden hier auch zur Energiegewinnung herangezogen, wovon sich die Exkursionsteilnehmer bei einer Besichtigung der Geothermal Power Station of Warakei {\"u}berzeugen konnten. Auf der Fahrt zum Tongariro Nationalpark bewunderten sie die Huka Falls und machten Halt am Lake Taupo, dem gr{\"o}ßten See Neuseelands. Im Nationalpark unternahmen sie am 26. Februar eine Wanderung. Tags darauf fuhren sie weiter {\"u}ber Marton nach Wellington, der Hauptstadt Neuseelands. Dort war nachmittags sowie am 28. Februar Gelegenheit, die Stadt zu erkunden, unter anderem auf einer Stadtf{\"u}hrung mit Prof. Bredlich. Daneben erfuhr man bei einem Besuch des neuseel{\"a}ndischen Nationalmuseums Te Papa viel Wissenswertes {\"u}ber Gesellschaft und Geschichte Neuseelands. Am 1. M{\"a}rz {\"u}berquerten sie mit der F{\"a}hre die Cookstraße, um zur S{\"u}dinsel zu gelangen. Den Nachmittag dieses Tages verbrachte die Exkursionsgruppe in Upper Moutere, wo sie sich mit der Einwanderung Deutscher in der Region Nelson befasste Am Tag darauf fuhren die Teilnehmer zur Westk{\"u}ste und besch{\"a}ftigten sich mit den Landschaftsformen der S{\"u}dalpen und der K{\"u}ste sowie mit der Frage, welche wirtschaftliche Rolle diese Region einst spielte und welche sie heute einnimmt. Am 3. M{\"a}rz {\"u}berquerten sie die S{\"u}dalpen {\"u}ber den Athur's Pass und kamen am Nachmittag in Christchurch an. Am n{\"a}chsten Tag erlebten sie eine Besichtigungstour durch die gr{\"o}ßte Stadt der S{\"u}dinsel unter Leitung von Prof. Parson vom Institut f{\"u}r Geographie der Universit{\"a}t von Canterbury. Dabei standen insbesondere Fragen des st{\"a}dtischen Wandels im Mittelpunkt, welcher mit den {\"o}konomischen Reformen seit Ende der 80er Jahre des letzten Jahrhunderts einherging. Damit endete am 4. M{\"a}rz die Exkursion in Christchurch. Zum zweiten Teil des Berichts - die thematischen Texte Neben dem Gewinn eines ersten Eindrucks vor Ort bietet eine Exkursion als Form der Erkundung eines Landes durchaus auch die Gelegenheit, kritisch {\"u}ber gesellschaftliche Vorg{\"a}nge zu reflektieren. {\"U}ber solche Reflexionen geben die Darstellungen im zweiten Teil dieses Exkursionsberichtes Aufschluss. Das Spektrum der in den Texten aufgegriffenen Themen reicht dabei von physisch-geographischen Gegebenheiten, {\"u}ber Land- und Forstwirtschaft, die Maori bis zu bev{\"o}lkerungsgeographischen Fragestellungen zur Migration und Integration in Neuseeland. Dem zu Grunde liegt ein - in der Geographie lange verwurzeltes - holistisches Verst{\"a}ndnis der Disziplin. In den Berichten findet die zentrale Debatte in der Geographie um die Bedeutung und das Zusammenspiel von globalen, regionsunabh{\"a}ngigen und lokalen, regionsspezifischen Faktoren (»Glokalisierung«) an vielen Stellen ihren Ausdruck. Da w{\"a}hrend der Exkursion Einblick in verschiedenste Bereiche des Lebens in Neuseeland gewonnen werden konnten, ist es im thematischen zweiten Teil des Berichts vorrangiges Ziel, einen guten {\"U}berblick {\"u}ber Neuseeland und seine Bev{\"o}lkerung zu geben. Dabei {\"u}berwiegt ein beschreibender Charakter der Texte, gleichzeitig sollen aber auch zentrale Ver{\"a}nderungen und Herausforderungen f{\"u}r die neuseel{\"a}ndische Gesellschaft angesprochen, Erkl{\"a}rungsans{\"a}tze gegeben und L{\"o}sungsstrategien aufgewiesen werden. Im Einzelnen ist der thematische Teil folgendermaßen aufgebaut: Zu Beginn widmet sich Anja Lehmann den Maori und beleuchtet Geschichte, Kultur und heutige Situation der indigenen Bev{\"o}lkerung Neuseelands. Anschließend gehen Katharina Popig und Manuel Hundt in ihrem Text auf die fr{\"u}he europ{\"a}ische Einwanderung nach Neuseeland, insbesondere auf die Rolle der deutschen bzw. b{\"o}hmischen Einwanderer, ein. Im darauf folgenden Text zeigt Manuel Hundt die sich ver{\"a}ndernden Muster in der j{\"u}ngeren Migration auf und beleuchtet Fragen der Integration in Neuseeland, wobei insbesondere auf die Rolle der Pacific Islanders eingegangen wird. Dann folgt der Text von Lilli Maier. Sie besch{\"a}ftigt sich mit Fragen des Tourismus und schildert die Gestalt des Fremdenverkehrs und seine Bedeutung f{\"u}r die neuseel{\"a}ndische Wirtschaft. Natalia Kiselgof gibt einen {\"U}berblick sowohl {\"u}ber physisch-geographische Aspekte und den Naturraum Neuseelands als auch {\"u}ber die Struktur der neuseel{\"a}ndischen Landwirtschaft, bevor S{\"o}ren Sturm die Forstwirtschaft Neuseelands einer kritischen Analyse unterzieht.},
language = {de}
}
@article{ThierbachNeissGallandietal.2017,
author = {Thierbach, Adrian and Neiss, Christian and Gallandi, Lukas and Marom, Noa and Koerzdoerfer, Thomas and Goerling, Andreas},
title = {Accurate Valence Ionization Energies from Kohn-Sham Eigenvalues with the Help of Potential Adjustors},
series = {Journal of chemical theory and computation},
volume = {13},
journal = {Journal of chemical theory and computation},
publisher = {American Chemical Society},
address = {Washington},
issn = {1549-9618},
doi = {10.1021/acs.jctc.7b00490},
pages = {4726 -- 4740},
year = {2017},
abstract = {An accurate yet computationally very efficient and formally well justified approach to calculate molecular ionization potentials is presented and tested. The first as well as higher ionization potentials are obtained as the negatives of the Kohn-Sham eigenvalues of the neutral molecule after adjusting the eigenvalues by a recently [Gorling Phys. Rev. B 2015, 91, 245120] introduced potential adjustor for exchange-correlation potentials. Technically the method is very simple. Besides a Kohn-Sham calculation of the neutral molecule, only a second Kohn-Sham calculation of the cation is required. The eigenvalue spectrum of the neutral molecule is shifted such that the negative of the eigenvalue of the highest occupied molecular orbital equals the energy difference of the total electronic energies of the cation minus the neutral molecule. For the first ionization potential this simply amounts to a Delta SCF calculation. Then, the higher ionization potentials are obtained as the negatives of the correspondingly shifted Kohn-Sham eigenvalues. Importantly, this shift of the Kohn-Sham eigenvalue spectrum is not just ad hoc. In fact, it is formally necessary for the physically correct energetic adjustment of the eigenvalue spectrum as it results from ensemble density-functional theory. An analogous approach for electron affinities is equally well obtained and justified. To illustrate the practical benefits of the approach, we calculate the valence ionization energies of test sets of small- and medium-sized molecules and photoelectron spectra of medium-sized electron acceptor molecules using a typical semilocal (PBE) and two typical global hybrid functionals (B3LYP and PBE0). The potential adjusted B3LYP and PBE0 eigenvalues yield valence ionization potentials that are in very good agreement with experimental values, reaching an accuracy that is as good as the best G(0)W(0) methods, however, at much lower computational costs. The potential adjusted PBE eigenvalues result in somewhat less accurate ionization energies, which, however, are almost as accurate as those obtained from the most commonly used G(0)W(0) variants.},
language = {en}
}
@article{KubinKernGuletal.2017,
author = {Kubin, Markus and Kern, Jan and Gul, Sheraz and Kroll, Thomas and Chatterjee, Ruchira and Loechel, Heike and Fuller, Franklin D. and Sierra, Raymond G. and Quevedo, Wilson and Weniger, Christian and Rehanek, Jens and Firsov, Anatoly and Laksmono, Hartawan and Weninger, Clemens and Alonso-Mori, Roberto and Nordlund, Dennis L. and Lassalle-Kaiser, Benedikt and Glownia, James M. and Krzywinski, Jacek and Moeller, Stefan and Turner, Joshua J. and Minitti, Michael P. and Dakovski, Georgi L. and Koroidov, Sergey and Kawde, Anurag and Kanady, Jacob S. and Tsui, Emily Y. and Suseno, Sandy and Han, Zhiji and Hill, Ethan and Taguchi, Taketo and Borovik, Andrew S. and Agapie, Theodor and Messinger, Johannes and Erko, Alexei and F{\"o}hlisch, Alexander and Bergmann, Uwe and Mitzner, Rolf and Yachandra, Vittal K. and Yano, Junko and Wernet, Philippe},
title = {Soft x-ray absorption spectroscopy of metalloproteins and high-valent metal-complexes at room temperature using free-electron lasers},
series = {Structural dynamics},
volume = {4},
journal = {Structural dynamics},
publisher = {American Institute of Physics},
address = {Melville},
issn = {2329-7778},
doi = {10.1063/1.4986627},
pages = {16},
year = {2017},
abstract = {X-ray absorption spectroscopy at the L-edge of 3d transition metals provides unique information on the local metal charge and spin states by directly probing 3d-derived molecular orbitals through 2p-3d transitions. However, this soft x-ray technique has been rarely used at synchrotron facilities for mechanistic studies of metalloenzymes due to the difficulties of x-ray-induced sample damage and strong background signals from light elements that can dominate the low metal signal. Here, we combine femtosecond soft x-ray pulses from a free-electron laser with a novel x-ray fluorescence-yield spectrometer to overcome these difficulties. We present L-edge absorption spectra of inorganic high-valent Mn complexes (Mn similar to 6-15 mmol/l) with no visible effects of radiation damage. We also present the first L-edge absorption spectra of the oxygen evolving complex (Mn4CaO5) in Photosystem II (Mn < 1 mmol/l) at room temperature, measured under similar conditions. Our approach opens new ways to study metalloenzymes under functional conditions. (C) 2017 Author(s).},
language = {en}
}
@article{KrollKernKubinetal.2016,
author = {Kroll, Thomas and Kern, Jan and Kubin, Markus and Ratner, Daniel and Gul, Sheraz and Fuller, Franklin D. and L{\"o}chel, Heike and Krzywinski, Jacek and Lutman, Alberto and Ding, Yuantao and Dakovski, Georgi L. and Moeller, Stefan and Turner, Joshua J. and Alonso-Mori, Roberto and Nordlund, Dennis L. and Rehanek, Jens and Weniger, Christian and Firsov, Alexander and Brzhezinskaya, Maria and Chatterjee, Ruchira and Lassalle-Kaiser, Benedikt and Sierra, Raymond G. and Laksmono, Hartawan and Hill, Ethan and Borovik, Andrew S. and Erko, Alexei and F{\"o}hlisch, Alexander and Mitzner, Rolf and Yachandra, Vittal K. and Yano, Junko and Wernet, Philippe and Bergmann, Uwe},
title = {X-ray absorption spectroscopy using a self-seeded soft X-ray free-electron laser},
series = {Optics express : the international electronic journal of optics},
volume = {24},
journal = {Optics express : the international electronic journal of optics},
publisher = {Optical Society of America},
address = {Washington},
issn = {1094-4087},
doi = {10.1364/OE.24.022469},
pages = {22469 -- 22480},
year = {2016},
abstract = {X-ray free electron lasers (XFELs) enable unprecedented new ways to study the electronic structure and dynamics of transition metal systems. L-edge absorption spectroscopy is a powerful technique for such studies and the feasibility of this method at XFELs for solutions and solids has been demonstrated. However, the required x-ray bandwidth is an order of magnitude narrower than that of self-amplified spontaneous emission (SASE), and additional monochromatization is needed. Here we compare L-edge x-ray absorption spectroscopy (XAS) of a prototypical transition metal system based on monochromatizing the SASE radiation of the linac coherent light source (LCLS) with a new technique based on self-seeding of LCLS. We demonstrate how L-edge XAS can be performed using the self-seeding scheme without the need of an additional beam line monochromator. We show how the spectral shape and pulse energy depend on the undulator setup and how this affects the x-ray spectroscopy measurements. (C) 2016 Optical Society of America},
language = {en}
}
@article{SchickLeGuyaderPontiusetal.2016,
author = {Schick, Daniel and Le Guyader, Loic and Pontius, Niko and Radu, Ilie and Kachel, Torsten and Mitzner, Rolf and Zeschke, Thomas and Schuessler-Langeheine, Christian and F{\"o}hlisch, Alexander and Holldack, Karsten},
title = {Analysis of the halo background in femtosecond slicing experiments},
series = {Journal of synchrotron radiation},
volume = {23},
journal = {Journal of synchrotron radiation},
publisher = {International Union of Crystallography},
address = {Chester},
issn = {1600-5775},
doi = {10.1107/S160057751600401X},
pages = {700 -- 711},
year = {2016},
abstract = {The slicing facility FemtoSpeX at BESSY II offers unique opportunities to study photo-induced dynamics on femtosecond time scales by means of X-ray magnetic circular dichroism, resonant and non-resonant X-ray diffraction, and X-ray absorption spectroscopy experiments in the soft X-ray regime. Besides femtosecond X-ray pulses, slicing sources inherently also produce a so-called `halo' background with a different time structure, polarization and pointing. Here a detailed experimental characterization of the halo radiation is presented, and a method is demonstrated for its correct and unambiguous removal from femtosecond time-resolved data using a special laser triggering scheme as well as analytical models. Examples are given for time-resolved measurements with corresponding halo correction, and errors of the relevant physical quantities caused by either neglecting or by applying a simplified model to describe this background are estimated.},
language = {en}
}
@article{RieboldRussowSchlegeletal.2020,
author = {Riebold, Diana and Russow, Kati and Schlegel, Mathias and Wollny, Theres and Thiel, Joerg and Freise, Jona and Hueppop, Ommo and Eccard, Jana and Plenge-Boenig, Anita and Loebermann, Micha and Ulrich, Rainer G{\"u}nter and Klammt, Sebastian and Mettenleiter, Thomas Christoph and Reisinger, Emil Christian},
title = {Occurrence of gastrointestinal parasites in small mammals from Germany},
series = {Vector borne and zoonotic diseases},
volume = {20},
journal = {Vector borne and zoonotic diseases},
number = {2},
publisher = {Liebert},
address = {New Rochelle},
issn = {1530-3667},
doi = {10.1089/vbz.2019.2457},
pages = {125 -- 133},
year = {2020},
abstract = {An increase in zoonotic infections in humans in recent years has led to a high level of public interest. However, the extent of infestation of free-living small mammals with pathogens and especially parasites is not well understood. This pilot study was carried out within the framework of the "Rodent-borne pathogens" network to identify zoonotic parasites in small mammals in Germany. From 2008 to 2009, 111 small mammals of 8 rodent and 5 insectivore species were collected. Feces and intestine samples from every mammal were examined microscopically for the presence of intestinal parasites by using Telemann concentration for worm eggs, Kinyoun staining for coccidia, and Heidenhain staining for other protozoa. Adult helminths were additionally stained with carmine acid for species determination. Eleven different helminth species, five coccidians, and three other protozoa species were detected. Simultaneous infection of one host by different helminths was common. Hymenolepis spp. (20.7\%) were the most common zoonotic helminths in the investigated hosts. Coccidia, including Eimeria spp. (30.6\%), Cryptosporidium spp. (17.1\%), and Sarcocystis spp. (17.1\%), were present in 40.5\% of the feces samples of small mammals. Protozoa, such as Giardia spp. and amoebae, were rarely detected, most likely because of the repeated freeze-thawing of the samples during preparation. The zoonotic pathogens detected in this pilot study may be potentially transmitted to humans by drinking water, smear infection, and airborne transmission.},
language = {en}
}
@article{BalischewskiChoiBehrensetal.2021,
author = {Balischewski, Christian and Choi, Hyung-Seok and Behrens, Karsten and Beqiraj, Alkit and K{\"o}rzd{\"o}rfer, Thomas and Gessner, Andre and Wedel, Armin and Taubert, Andreas},
title = {Metal sulfide nanoparticle synthesis with ionic liquids state of the art and future perspectives},
series = {ChemistryOpen},
volume = {10},
journal = {ChemistryOpen},
number = {2},
publisher = {Wiley-VCH},
address = {Weinheim},
issn = {2191-1363},
doi = {10.1002/open.202000357},
pages = {272 -- 295},
year = {2021},
abstract = {Metal sulfides are among the most promising materials for a wide variety of technologically relevant applications ranging from energy to environment and beyond. Incidentally, ionic liquids (ILs) have been among the top research subjects for the same applications and also for inorganic materials synthesis. As a result, the exploitation of the peculiar properties of ILs for metal sulfide synthesis could provide attractive new avenues for the generation of new, highly specific metal sulfides for numerous applications. This article therefore describes current developments in metal sulfide nano-particle synthesis as exemplified by a number of highlight examples. Moreover, the article demonstrates how ILs have been used in metal sulfide synthesis and discusses the benefits of using ILs over more traditional approaches. Finally, the article demonstrates some technological challenges and how ILs could be used to further advance the production and specific property engineering of metal sulfide nanomaterials, again based on a number of selected examples.},
language = {en}
}
@article{FalkKirkLohmannetal.2017,
author = {Falk, Thomas and Kirk, Michael and Lohmann, Dirk and Kruger, Bertus and H{\"u}ttich, Christian and Kamukuenjandje, Richard},
title = {The profits of excludability and transferability in redistributive land reform in central Namibia},
series = {Development Southern Africa},
volume = {34},
journal = {Development Southern Africa},
publisher = {Routledge, Taylor \& Francis Group},
address = {Abingdon},
issn = {0376-835X},
doi = {10.1080/0376835X.2016.1269633},
pages = {314 -- 329},
year = {2017},
abstract = {Policies which redistribute property rights to land can improve the well-being of rural households and can have overall growth effects. In many cases, however, land reforms are driven mainly by politically justified objectives. Under such circumstances, little emphasis is placed on whether and, if so, how property rights can increase productivity. Following 18 years of land reform implementation in Namibia, we evaluated 65 beneficiaries in Namibia. We assess to which degree land rights affects their farm income. The study focuses on Namibia's two main commercial land reform instruments, namely the Farm Unit Resettlement Scheme and the Affirmative Action Loan Scheme. We find evidence that the majority of land reform projects are not profitable. Further, our study confirms the importance of the right to restrict land access compared with the right to transfer. The long-term leasehold contract seemingly provides sufficient incentives to make productive use of the land.},
language = {en}
}
@misc{SpiekermannHarderGilmoreetal.2019,
author = {Spiekermann, Georg and Harder, M. and Gilmore, Keith and Zalden, Peter and Sahle, Christoph J. and Petitgirard, Sylvain and Wilke, Max and Biedermann, Nicole and Weis, Thomas and Morgenroth, Wolfgang and Tse, John S. and Kulik, E. and Nishiyama, Norimasa and Yava{\c{s}}, Hasan and Sternemann, Christian},
title = {Persistent Octahedral Coordination in Amorphous GeO₂ Up to 100 GPa by Kβ'' X-Ray Emission Spectroscopy},
series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
journal = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
number = {699},
issn = {1866-8372},
doi = {10.25932/publishup-42775},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427755},
year = {2019},
abstract = {We measure valence-to-core x-ray emission spectra of compressed crystalline GeO₂ up to 56 GPa and of amorphous GeO₂ up to 100 GPa. In a novel approach, we extract the Ge coordination number and mean Ge-O distances from the emission energy and the intensity of the Kβ'' emission line. The spectra of high-pressure polymorphs are calculated using the Bethe-Salpeter equation. Trends observed in the experimental and calculated spectra are found to match only when utilizing an octahedral model. The results reveal persistent octahedral Ge coordination with increasing distortion, similar to the compaction mechanism in the sequence of octahedrally coordinated crystalline GeO₂ high-pressure polymorphs.},
language = {en}
}
@article{SpiekermannHarderGilmoreetal.2019,
author = {Spiekermann, Georg and Harder, M. and Gilmore, Keith and Zalden, Peter and Sahle, Christoph J. and Petitgirard, Sylvain and Wilke, Max and Biedermann, Nicole and Weis, Thomas and Morgenroth, Wolfgang and Tse, John S. and Kulik, E. and Nishiyama, Norimasa and Yava{\c{s}}, Hasan and Sternemann, Christian},
title = {Persistent Octahedral Coordination in Amorphous GeO₂ Up to 100 GPa by Kβ'' X-Ray Emission Spectroscopy},
series = {Physical Review X},
volume = {9},
journal = {Physical Review X},
number = {1},
publisher = {American Physical Society by the American Institute of Physics},
address = {Melville, NY},
issn = {2469-9926},
doi = {10.1103/PhysRevX.9.011025},
pages = {10},
year = {2019},
abstract = {We measure valence-to-core x-ray emission spectra of compressed crystalline GeO₂ up to 56 GPa and of amorphous GeO₂ up to 100 GPa. In a novel approach, we extract the Ge coordination number and mean Ge-O distances from the emission energy and the intensity of the Kβ'' emission line. The spectra of high-pressure polymorphs are calculated using the Bethe-Salpeter equation. Trends observed in the experimental and calculated spectra are found to match only when utilizing an octahedral model. The results reveal persistent octahedral Ge coordination with increasing distortion, similar to the compaction mechanism in the sequence of octahedrally coordinated crystalline GeO₂ high-pressure polymorphs.},
language = {en}
}
@article{KuhlickeSeebauerHudsonetal.2020,
author = {Kuhlicke, Christian and Seebauer, Sebastian and Hudson, Paul and Begg, Chloe and Bubeck, Philip and Dittmer, Cordula and Grothmann, Torsten and Heidenreich, Anna and Kreibich, Heidi and Lorenz, Daniel F. and Masson, Torsten and Reiter, Jessica and Thaler, Thomas and Thieken, Annegret and Bamberg, Sebastian},
title = {The behavioral turn in flood risk management, its assumptions and potential implications},
series = {WIREs Water},
volume = {7},
journal = {WIREs Water},
number = {3},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {2049-1948},
doi = {10.1002/wat2.1418},
pages = {1 -- 22},
year = {2020},
abstract = {Recent policy changes highlight the need for citizens to take adaptive actions to reduce flood-related impacts. Here, we argue that these changes represent a wider behavioral turn in flood risk management (FRM). The behavioral turn is based on three fundamental assumptions: first, that the motivations of citizens to take adaptive actions can be well understood so that these motivations can be targeted in the practice of FRM; second, that private adaptive measures and actions are effective in reducing flood risk; and third, that individuals have the capacities to implement such measures. We assess the extent to which the assumptions can be supported by empirical evidence. We do this by engaging with three intellectual catchments. We turn to research by psychologists and other behavioral scientists which focus on the sociopsychological factors which influence individual motivations (Assumption 1). We engage with economists, engineers, and quantitative risk analysts who explore the extent to which individuals can reduce flood related impacts by quantifying the effectiveness and efficiency of household-level adaptive measures (Assumption 2). We converse with human geographers and sociologists who explore the types of capacities households require to adapt to and cope with threatening events (Assumption 3). We believe that an investigation of the behavioral turn is important because if the outlined assumptions do not hold, there is a risk of creating and strengthening inequalities in FRM. Therefore, we outline the current intellectual and empirical knowledge as well as future research needs. Generally, we argue that more collaboration across intellectual catchments is needed, that future research should be more theoretically grounded and become methodologically more rigorous and at the same time focus more explicitly on the normative underpinnings of the behavioral turn.},
language = {en}
}
@misc{KuhlickeSeebauerHudsonetal.2020,
author = {Kuhlicke, Christian and Seebauer, Sebastian and Hudson, Paul and Begg, Chloe and Bubeck, Philip and Dittmer, Cordula and Grothmann, Torsten and Heidenreich, Anna and Kreibich, Heidi and Lorenz, Daniel F. and Masson, Torsten and Reiter, Jessica and Thaler, Thomas and Thieken, Annegret and Bamberg, Sebastian},
title = {The behavioral turn in flood risk management, its assumptions and potential implications},
series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
number = {3},
issn = {1866-8372},
doi = {10.25932/publishup-51769},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517696},
pages = {24},
year = {2020},
abstract = {Recent policy changes highlight the need for citizens to take adaptive actions to reduce flood-related impacts. Here, we argue that these changes represent a wider behavioral turn in flood risk management (FRM). The behavioral turn is based on three fundamental assumptions: first, that the motivations of citizens to take adaptive actions can be well understood so that these motivations can be targeted in the practice of FRM; second, that private adaptive measures and actions are effective in reducing flood risk; and third, that individuals have the capacities to implement such measures. We assess the extent to which the assumptions can be supported by empirical evidence. We do this by engaging with three intellectual catchments. We turn to research by psychologists and other behavioral scientists which focus on the sociopsychological factors which influence individual motivations (Assumption 1). We engage with economists, engineers, and quantitative risk analysts who explore the extent to which individuals can reduce flood related impacts by quantifying the effectiveness and efficiency of household-level adaptive measures (Assumption 2). We converse with human geographers and sociologists who explore the types of capacities households require to adapt to and cope with threatening events (Assumption 3). We believe that an investigation of the behavioral turn is important because if the outlined assumptions do not hold, there is a risk of creating and strengthening inequalities in FRM. Therefore, we outline the current intellectual and empirical knowledge as well as future research needs. Generally, we argue that more collaboration across intellectual catchments is needed, that future research should be more theoretically grounded and become methodologically more rigorous and at the same time focus more explicitly on the normative underpinnings of the behavioral turn.},
language = {en}
}
@book{ThiekenBesselCallsenetal.2015,
author = {Thieken, Annegret and Bessel, Tina and Callsen, Ines and Falter, Daniela and Hasan, Issa and Kienzler, Sarah and Kox, Thomas and Kreibich, Heidi and Kuhlicke, Christian and Kunz, Michael and Matthias, Max and Meyer, Volker and M{\"u}hr, Bernhard and M{\"u}ller, Meike and Otto, Antje and Pech, Ina and Petrow, Theresia and Pisi, Sebastian and Rother, Karl-Heinz and Schr{\"o}ter, Kai},
title = {Das Hochwasser im Juni 2013},
series = {Schriftenreihe des DKKV ; 53},
journal = {Schriftenreihe des DKKV ; 53},
publisher = {Deutsches Komitee Katastrophenvorsorge},
address = {Bonn},
isbn = {978-3-933181-62-6},
publisher = {Universit{\"a}t Potsdam},
pages = {207},
year = {2015},
language = {de}
}
@article{DebatinBehrensWeberetal.2012,
author = {Debatin, Franziska and Behrens, Karsten and Weber, Jens and Baburin, Igor A. and Thomas, Arne and Schmidt, Johannes and Senkovska, Irena and Kaskel, Stefan and Kelling, Alexandra and Hedin, Niklas and Bacsik, Zoltan and Leoni, Stefano and Seifert, Gotthard and J{\"a}ger, Christian and G{\"u}nter, Christina and Schilde, Uwe and Friedrich, Alwin and Holdt, Hans-J{\"u}rgen},
title = {An isoreticular family of microporous metal-organic frameworks based on zinc and 2-substituted imidazolate-4-amide-5-imidate Syntheses, structures and properties},
series = {Chemistry - a European journal},
volume = {18},
journal = {Chemistry - a European journal},
number = {37},
publisher = {Wiley-VCH},
address = {Weinheim},
issn = {0947-6539},
doi = {10.1002/chem.201200889},
pages = {11630 -- 11640},
year = {2012},
abstract = {We report on a new series of isoreticular frameworks based on zinc and 2-substituted imidazolate-4-amide-5-imidate (IFP-14, IFP=imidazolate framework Potsdam) that form one-dimensional, microporous hexagonal channels. Varying R in the 2-substitued linker (R=Me (IFP-1), Cl (IFP-2), Br (IFP-3), Et (IFP-4)) allowed the channel diameter (4.01.7 angstrom), the polarisability and functionality of the channel walls to be tuned. Frameworks IFP-2, IFP-3 and IFP-4 are isostructural to previously reported IFP-1. The structures of IFP-2 and IFP-3 were solved by X-ray crystallographic analyses. The structure of IFP-4 was determined by a combination of PXRD and structure modelling and was confirmed by IR spectroscopy and 1H MAS and 13C CP-MAS NMR spectroscopy. All IFPs showed high thermal stability (345400?degrees C); IFP-1 and IFP-4 were stable in boiling water for 7 d. A detailed porosity analysis was performed on the basis of adsorption measurements by using various gases. The potential of the materials to undergo specific interactions with CO2 was investigated by measuring the isosteric heats of adsorption. The capacity to adsorb CH4 (at 298 K), CO2 (at 298 K) and H2 (at 77 K) at high pressure were also investigated. In situ IR spectroscopy showed that CO2 is physisorbed on IFP-14 under dry conditions and that both CO2 and H2O are physisorbed on IFP-1 under moist conditions.},
language = {en}
}
@misc{KnoblochCheirifWoloskyEstevamOFernandesetal.2014,
author = {Knobloch, Eberhard and Cheirif Wolosky, Alejandro and Estevam O. Fernandes, Luiz and Erdmann, Dominik and Honigmann, Peter and Thomas, Christian and Treuber, Konstantin and Werner, Anja},
title = {HiN : Alexander von Humboldt im Netz},
series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies},
volume = {XV},
journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies},
number = {28},
editor = {Ette, Ottmar and Knobloch, Eberhard},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
issn = {1617-5239},
doi = {10.18443/hinvol15iss282014},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-84097},
pages = {79},
year = {2014},
abstract = {Inhalt: Eberhard Knobloch: Der Briefwechsel zwischen Alexander von Humboldt und Charles Lyell: Ein {\"U}berblick Alejandro Cheirif Wolosky: La recepci{\´o}n humboldtiana de Crist{\´o}bal Col{\´o}n Luiz Estevam O. Fernandes: Political Essay on the Kingdom of New Spain: Humboldt and the history of Mexico Dominik Erdmann/Christian Thomas: „… zu den wunderlichsten Schlangen der Gelehrsasmkeit zusammengegliedert". Neue Materialien zu den ‚Kosmos-Vortr{\"a}gen' Alexander von Humboldts, nebst Vor{\"u}berlegungen zu deren digitaler Edition Konstantin Treuber „Warum ich nicht Diorit-Trachyt sagen soll." - Ein geologischer Brief Gustav Roses an Alexander von Humboldt Anja Werner: Alexander von Humboldt's Footnotes: "Networks of Knowledge" in the Sources of the 1826 Essai politique sur l'{\^i}le de Cuba Peter Honigmann: Alexander von Humboldts Journale seiner russisch-sibirischen Reise 1829 [mit einer Einf{\"u}hrung von Eberhard Knobloch]},
language = {mul}
}
@misc{EtteKnoblochSchwarzetal.2014,
author = {Ette, Ottmar and Knobloch, Eberhard and Schwarz, Oliver and Werner, Petra and Suckow, Christian and Jobst, Anne and Schmuck, Thomas and Ringmacher, Manfred and Tintemann, Ute and Leitner, Ulrike and Holl, Frank and Panwitz, Sebastian and P{\´e}aud, Laura and Holtz, B{\"a}rbel and Folkerts, Menso and P{\"a}ßler, Ulrich and Roba, Bill},
title = {HiN : Alexander von Humboldt im Netz = Ingo Schwarz zum 65. Geburtstag},
series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies},
volume = {XV},
journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies},
number = {29},
editor = {Ette, Ottmar and Knobloch, Eberhard},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
issn = {1617-5239},
doi = {10.18443/hinvol15iss292014},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-85033},
pages = {201},
year = {2014},
abstract = {Inhalt: Alexander von Humboldt-Forschungsstelle: Ingo Schwarz zum 65. Geburtstag Ottmar Ette: Findung und Erfindung einer Leserschaft. Neuere Editionsprojekte zu Alexander von Humboldt als Grundlage und Herausforderung k{\"u}nftigen Forschens Eberhard Knobloch: Alexandre de Humboldt et le Marquis de Laplace Oliver Schwarz: Alexander von Humboldt als astronomischer Arbeiter, Diskussionspartner und Ideengeber Petra Werner: Innenwelten und bleiche G{\"a}rten. Alexander von Humboldt untertage und in der Caripe-H{\"o}hle Christian Suckow: Alexander von Humboldt in Ust'-Kamenogorsk Anne Jobst: Neue Briefe Christian Gottfried Ehrenbergs an Alexander von Humboldt Thomas Schmuck: Humboldt, Baer und die Evolution Manfred Ringmacher: Zwei Briefe auf Guaran{\´i} in Alexander von Humboldts Handschrift Ute Tintemann: Julius Klaproths Mithridates-Projekt, Alexander von Humboldt und das Verlagshaus Cotta Ulrike Leitner: „Ja! Wenn Berlin Bonn w{\"a}re!" Friedrich R{\"u}ckerts Berufung nach Berlin Frank Holl: „Zur Freiheit bestimmt" - Alexander von Humboldts Blick auf die Kulturen der Welt Sebastian Panwitz: Das Humboldt-Mendelssohn-Haus J{\"a}gerstraße 22. Ein Quellenfund Laura P{\´e}aud: Du Mexique {\`a} l'Oural : l'expertise humboldtienne au service du politique B{\"a}rbel Holtz: „Cicerone" des K{\"o}nigs? Alexander von Humboldt und Friedrich Wilhelm III. Menso Folkerts: Ein unerwartetes Zusammentreffen in Sanssouci. Alexander von Humboldt und Karl Ludwig Hencke an der Tafel Friedrich Wilhelms IV. Ulrich P{\"a}ßler: Preußens Mann in Washington. F{\"u}nf Briefe Friedrich von Gerolts an Alexander von Humboldt (1858/1859) Bill Roba: German-Iowan Strategies in Celebrating the Centennial of Alexander von Humboldt's Birth Regina Mikosch: Ingo Schwarz' Ver{\"o}ffentlichungen zur Alexander von Humboldt {\"U}ber die Autoren},
language = {mul}
}
@article{ErdmannThomas2015,
author = {Erdmann, Dominik and Thomas, Christian},
title = {„… zu den wunderlichsten Schlangen der Gelehrsamkeit zusammengegliedert"},
series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
volume = {XV},
journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
number = {28},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
issn = {1617-5239},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-84054},
pages = {34 -- 45},
year = {2015},
abstract = {Alexander von Humboldts 1827/28 gehaltene Kosmos-Vortr{\"a}ge stellen ebenso einen kanonischen Bezugspunkt wie einen weißen Fleck in der Rezeption seines Schaffens dar. Zahlreiche Deutungen basieren auf lediglich zwei unkommentierten Leseausgaben von Collegheften anonym gebliebener Zuh{\"o}rer Humboldts. Seine 2009 wiedergefundenen eigenh{\"a}ndigen Vorlesungsmanuskripte versprechen, diese schmale Quellenbasis zu erweitern. Alfred Dove hatte bereits 1872 auf ihre Existenz verwiesen und interpretierte sie damals als Nukleus der schriftlichen Ausarbeitung des Kosmos. Diese Sichtweise hat sich in der Rezeption gehalten, w{\"a}hrend die Materialien, die Dove beschrieb, in Vergessenheit gerieten. Der Artikel stellt anhand ausgew{\"a}hlter Beispiele die Vorlesungsmanuskripte Humboldts und Nachschriften seiner Zuh{\"o}rer in ihrem Zusammenhang vor, entwickelt die These von der Eigenst{\"a}ndigkeit der sogenannten Kosmos-Vortr{\"a}ge gegen{\"u}ber dem f{\"u}nfb{\"a}ndigen Kosmos und umreißt die wichtigsten Ziele und Inhalte der geplanten digitalen Edition.},
language = {de}
}
@article{GereckeSchumacherBerndzenetal.2019,
author = {Gerecke, Christian and Schumacher, Fabian and Berndzen, Alide and Homann, Thomas and Kleuser, Burkhard},
title = {Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells},
series = {Epigenetics : the official journal of the DNA Methylation Society},
volume = {15},
journal = {Epigenetics : the official journal of the DNA Methylation Society},
number = {3},
publisher = {Taylor \& Francis Group},
address = {Philadelphia},
issn = {1559-2294},
doi = {10.1080/15592294.2019.1666652},
pages = {307 -- 322},
year = {2019},
abstract = {Mutations in the enzyme isocitrate dehydrogenase 1 (IDH1) lead to metabolic alterations and a sustained formation of 2-hydroxyglutarate (2-HG). 2-HG is an oncometabolite as it inhibits the activity of alpha-ketoglutarate-dependent dioxygenases such as ten-eleven translocation (TET) enzymes. Inhibitors of mutant IDH enzymes, like ML309, are currently tested in order to lower the levels of 2-HG. Vitamin C (VC) is an inducer of TET enzymes. To test a new therapeutic avenue of synergistic effects, the anti-neoplastic activity of inhibition of mutant IDH1 via ML309 in the presence of VC was investigated in the colon cancer cell line HCT116 IDH1(R132H/+) (harbouring a mutated IDH1 allele) and the parental cells HCT116 IDH1(+/+) (wild type IDH1). Measurement of the oncometabolite indicated a 56-fold higher content of 2-HG in mutated cells compared to wild type cells. A significant reduction of 2-HG was observed in mutated cells after treatment with ML 309, whereas VC produced only minimally changes of the oncometabolite. However, combinatorial treatment with both, ML309 and VC, in mutated cells induced pronounced reduction of 2-HG leading to levels comparable to those in wild type cells. The decreased level of 2-HG in mutated cells after combinatorial treatment was accompanied by an enhanced global DNA hydroxymethylation and an increased gene expression of certain tumour suppressors. Moreover, mutated cells showed an increased percentage of apoptotic cells after treatment with non-cytotoxic concentrations of ML309 and VC. These results suggest that combinatorial therapy is of interest for further investigation to rescue TET activity and treatment of IDH1/2 mutated cancers.},
language = {en}
}