@article{MartinezValdesNegroLaineetal.2017, author = {Martinez-Valdes, Eduardo Andr{\´e}s and Negro, F. and Laine, C. M. and Falla, D. and Mayer, Frank and Farina, Dario}, title = {Tracking motor units longitudinally across experimental sessions with high-density surface electromyography}, series = {The Journal of Physiology}, volume = {595}, journal = {The Journal of Physiology}, publisher = {Wiley}, address = {Hoboken}, issn = {0022-3751}, doi = {10.1113/JP273662}, pages = {1479 -- 1496}, year = {2017}, abstract = {A new method is proposed for tracking individual motor units (MUs) across multiple experimental sessions on different days. The technique is based on a novel decomposition approach for high-density surface electromyography and was tested with two experimental studies for reliability and sensitivity. Experiment I (reliability): ten participants performed isometric knee extensions at 10, 30, 50 and 70\% of their maximum voluntary contraction (MVC) force in three sessions, each separated by 1 week. Experiment II (sensitivity): seven participants performed 2 weeks of endurance training (cycling) and were tested pre-post intervention during isometric knee extensions at 10 and 30\% MVC. The reliability (Experiment I) and sensitivity (Experiment II) of the measured MU properties were compared for the MUs tracked across sessions, with respect to all MUs identified in each session. In Experiment I, on average 38.3\% and 40.1\% of the identified MUs could be tracked across two sessions (1 and 2 weeks apart), for the vastus medialis and vastus lateralis, respectively. Moreover, the properties of the tracked MUs were more reliable across sessions than those of the full set of identified MUs (intra-class correlation coefficients ranged between 0.63-0.99 and 0.39-0.95, respectively). In Experiment II, similar to 40\% of the MUs could be tracked before and after the training intervention and training-induced changes in MU conduction velocity had an effect size of 2.1 (tracked MUs) and 1.5 (group of all identified motor units). These results show the possibility of monitoring MU properties longitudinally to document the effect of interventions or the progression of neuromuscular disorders.}, language = {en} } @article{MenzLatorreSchuetteetal.2012, author = {Menz, Stephan and Latorre, Juan C. and Sch{\"u}tte, Christof and Huisinga, Wilhelm}, title = {Hybrid stochastic-deterministic solution of the chemical master equation}, series = {Multiscale modeling \& simulation : a SIAM interdisciplinary journal}, volume = {10}, journal = {Multiscale modeling \& simulation : a SIAM interdisciplinary journal}, number = {4}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia}, issn = {1540-3459}, doi = {10.1137/110825716}, pages = {1232 -- 1262}, year = {2012}, abstract = {The chemical master equation (CME) is the fundamental evolution equation of the stochastic description of biochemical reaction kinetics. In most applications it is impossible to solve the CME directly due to its high dimensionality. Instead, indirect approaches based on realizations of the underlying Markov jump process are used, such as the stochastic simulation algorithm (SSA). In the SSA, however, every reaction event has to be resolved explicitly such that it becomes numerically inefficient when the system's dynamics include fast reaction processes or species with high population levels. In many hybrid approaches, such fast reactions are approximated as continuous processes or replaced by quasi-stationary distributions in either a stochastic or a deterministic context. Current hybrid approaches, however, almost exclusively rely on the computation of ensembles of stochastic realizations. We present a novel hybrid stochastic-deterministic approach to solve the CME directly. Our starting point is a partitioning of the molecular species into discrete and continuous species that induces a partitioning of the reactions into discrete-stochastic and continuous-deterministic processes. The approach is based on a WKB (Wentzel-Kramers-Brillouin) ansatz for the conditional probability distribution function (PDF) of the continuous species (given a discrete state) in combination with Laplace's method of integral approximation. The resulting hybrid stochastic-deterministic evolution equations comprise a CME with averaged propensities for the PDF of the discrete species that is coupled to an evolution equation of the related expected levels of the continuous species for each discrete state. In contrast to indirect hybrid methods, the impact of the evolution of discrete species on the dynamics of the continuous species has to be taken into account explicitly. The proposed approach is efficient whenever the number of discrete molecular species is small. We illustrate the performance of the new hybrid stochastic-deterministic approach in an application to model systems of biological interest.}, language = {en} } @article{PiroRenard2023, author = {Piro, Vitor C. and Renard, Bernhard Y.}, title = {Contamination detection and microbiome exploration with GRIMER}, series = {GigaScience}, volume = {12}, journal = {GigaScience}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {2047-217X}, doi = {10.1093/gigascience/giad017}, pages = {13}, year = {2023}, abstract = {Background: Contamination detection is a important step that should be carefully considered in early stages when designing and performing microbiome studies to avoid biased outcomes. Detecting and removing true contaminants is challenging, especially in low-biomass samples or in studies lacking proper controls. Interactive visualizations and analysis platforms are crucial to better guide this step, to help to identify and detect noisy patterns that could potentially be contamination. Additionally, external evidence, like aggregation of several contamination detection methods and the use of common contaminants reported in the literature, could help to discover and mitigate contamination. Results: We propose GRIMER, a tool that performs automated analyses and generates a portable and interactive dashboard integrating annotation, taxonomy, and metadata. It unifies several sources of evidence to help detect contamination. GRIMER is independent of quantification methods and directly analyzes contingency tables to create an interactive and offline report. Reports can be created in seconds and are accessible for nonspecialists, providing an intuitive set of charts to explore data distribution among observations and samples and its connections with external sources. Further, we compiled and used an extensive list of possible external contaminant taxa and common contaminants with 210 genera and 627 species reported in 22 published articles. Conclusion: GRIMER enables visual data exploration and analysis, supporting contamination detection in microbiome studies. The tool and data presented are open source and available at https://gitlab.com/dacs-hpi/grimer.}, language = {en} } @misc{BookerJacobRappetal.2016, author = {Booker, Anke and Jacob, Louis E. C. and Rapp, Michael A. and Bohlken, Jens and Kostev, Karel}, title = {Risk factors for dementia diagnosis in German primary care practices}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {449}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-413441}, pages = {7}, year = {2016}, abstract = {Background: Dementia is a psychiatric condition the development of which is associated with numerous aspects of life. Our aim was to estimate dementia risk factors in German primary care patients. Methods: The case-control study included primary care patients (70-90 years) with first diagnosis of dementia (all-cause) during the index period (01/2010-12/2014) (Disease Analyzer, Germany), and controls without dementia matched (1:1) to cases on the basis of age, sex, type of health insurance, and physician. Practice visit records were used to verify that there had been 10 years of continuous follow-up prior to the index date. Multivariate logistic regression models were fitted with dementia as a dependent variable and the potential predictors. Results: The mean age for the 11,956 cases and the 11,956 controls was 80.4 (SD: 5.3) years. 39.0\% of them were male and 1.9\% had private health insurance. In the multivariate regression model, the following variables were linked to a significant extent with an increased risk of dementia: diabetes (OR: 1.17; 95\% CI: 1.10-1.24), lipid metabolism (1.07; 1.00-1.14), stroke incl. TIA (1.68; 1.57-1.80), Parkinson's disease (PD) (1.89; 1.64-2.19), intracranial injury (1.30; 1.00-1.70), coronary heart disease (1.06; 1.00-1.13), mild cognitive impairment (MCI) (2.12; 1.82-2.48), mental and behavioral disorders due to alcohol use (1.96; 1.50-2.57). The use of statins (OR: 0.94; 0.90-0.99), proton-pump inhibitors (PPI) (0.93; 0.90-0.97), and antihypertensive drugs (0.96, 0.94-0.99) were associated with a decreased risk of developing dementia. Conclusions: Risk factors for dementia found in this study are consistent with the literature. Nevertheless, the associations between statin, PPI and antihypertensive drug use, and decreased risk of dementia need further investigations.}, language = {en} } @article{HerzschuhPestryakovaSavelievaetal.2013, author = {Herzschuh, Ulrike and Pestryakova, Luidmila Agafyevna and Savelieva, Larissa A. and Heinecke, Liv and B{\"o}hmer, Thomas and Biskaborn, Boris and Andreev, Andrei and Ramisch, Arne and Shinneman, Avery L. C. and Birks, H. John B.}, title = {Siberian larch forests and the ion content of thaw lakes form a geochemically functional entity}, series = {Nature Communications}, volume = {4}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/ncomms3408}, pages = {8}, year = {2013}, abstract = {Siberian larch forests growing on shallow permafrost soils have not, until now, been considered to be controlling the abiotic and biotic characteristics of the vast number of thaw-lake ecosystems. Here we show, using four independent data sets (a modern data set from 201 lakes from the tundra to taiga, and three lake-core records), that lake-water geochemistry in Yakutia is highly correlated with vegetation. Alkalinity increases with catchment forest density. We postulate that in this arid area, higher evapotranspiration in larch forests compared with that in the tundra vegetation leads to local salt accumulation in soils. Solutes are transported to nearby thaw lakes during rain events and snow melt, but are not fully transported into rivers, because there is no continuous groundwater flow within permafrost soils. This implies that potentially large shifts in the chemical characteristics of aquatic ecosystems to known warming are absent because of the slow response of catchment forests to climate change.}, language = {en} } @article{SchmelzbachTronickeDietrich2012, author = {Schmelzbach, C. and Tronicke, Jens and Dietrich, P.}, title = {High-resolution water content estimation from surface-based ground-penetrating radar reflection data by impedance inversion}, series = {Water resources research}, volume = {48}, journal = {Water resources research}, number = {31}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0043-1397}, doi = {10.1029/2012WR011955}, pages = {16}, year = {2012}, abstract = {Mapping hydrological parameter distributions in high resolution is essential to understand and simulate groundwater flow and contaminant transport. Of particular interest is surface-based ground-penetrating radar (GPR) reflection imaging in electrically resistive sediments because of the expected close link between the subsurface water content and the dielectric permittivity, which controls GPR wave velocity and reflectivity. Conventional tools like common midpoint (CMP) velocity analysis provide physical parameter models of limited resolution only. We present a novel reflection amplitude inversion workflow for surface-based GPR data capable of resolving the subsurface dielectric permittivity and related water content distribution with markedly improved resolution. Our scheme is an adaptation of a seismic reflection impedance inversion scheme to surface-based GPR data. Key is relative-amplitude-preserving data preconditioning including GPR deconvolution, which results in traces with the source-wavelet distortions and propagation effects largely removed. The subsequent inversion for the underlying dielectric permittivity and water content structure is constrained by in situ dielectric permittivity data obtained by direct-push logging. After demonstrating the potential of our novel scheme on a realistic synthetic data set, we apply it to two 2-D 100 MHz GPR profiles acquired over a shallow sedimentary aquifer resulting in water content images of the shallow (3-7 m depth) saturated zone having decimeter resolution.}, language = {en} } @article{SchmelzbachScherbaumTronickeetal.2011, author = {Schmelzbach, C. and Scherbaum, Frank and Tronicke, Jens and Dietrich, P.}, title = {Bayesian frequency-domain blind deconvolution of ground-penetrating radar data}, series = {Journal of applied geophysics}, volume = {75}, journal = {Journal of applied geophysics}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0926-9851}, doi = {10.1016/j.jappgeo.2011.08.010}, pages = {615 -- 630}, year = {2011}, abstract = {Enhancing the resolution and accuracy of surface ground-penetrating radar (GPR) reflection data by inverse filtering to recover a zero-phased band-limited reflectivity image requires a deconvolution technique that takes the mixed-phase character of the embedded wavelet into account. In contrast, standard stochastic deconvolution techniques assume that the wavelet is minimum phase and, hence, often meet with limited success when applied to GPR data. We present a new general-purpose blind deconvolution algorithm for mixed-phase wavelet estimation and deconvolution that (1) uses the parametrization of a mixed-phase wavelet as the convolution of the wavelet's minimum-phase equivalent with a dispersive all-pass filter, (2) includes prior information about the wavelet to be estimated in a Bayesian framework, and (3) relies on the assumption of a sparse reflectivity. Solving the normal equations using the data autocorrelation function provides an inverse filter that optimally removes the minimum-phase equivalent of the wavelet from the data, which leaves traces with a balanced amplitude spectrum but distorted phase. To compensate for the remaining phase errors, we invert in the frequency domain for an all-pass filter thereby taking advantage of the fact that the action of the all-pass filter is exclusively contained in its phase spectrum. A key element of our algorithm and a novelty in blind deconvolution is the inclusion of prior information that allows resolving ambiguities in polarity and timing that cannot be resolved using the sparseness measure alone. We employ a global inversion approach for non-linear optimization to find the all-pass filter phase values for each signal frequency. We tested the robustness and reliability of our algorithm on synthetic data with different wavelets, 1-D reflectivity models of different complexity, varying levels of added noise, and different types of prior information. When applied to realistic synthetic 2-D data and 2-D field data, we obtain images with increased temporal resolution compared to the results of standard processing.}, language = {en} } @article{SchmelzbachTronickeDietrich2011, author = {Schmelzbach, C. and Tronicke, Jens and Dietrich, P.}, title = {Three-dimensional hydrostratigraphic models from ground-penetrating radar and direct-push data}, series = {Journal of hydrology}, volume = {398}, journal = {Journal of hydrology}, number = {3-4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2010.12.023}, pages = {235 -- 245}, year = {2011}, abstract = {Three-dimensional models of hydraulic conductivity and porosity are essential to understand and simulate groundwater flow in heterogeneous geological environments. However, considering the inherent limitations of traditional hydrogeological field methods in terms of resolution, alternative field approaches are needed to establish such 3-D models with sufficient accuracy. In this study, we developed a workflow combining 3-D structural information extracted from ground penetrating radar (GPR) images with 1-D in situ physical-property estimates from direct-push (DP) logging to construct a 3-D hydrostratigraphic model. To illustrate this workflow, we collected an similar to 70 m x 90 m 100 MHz 3-D GPR data set over a shallow sedimentary aquifer system resolving six different GPR facies down to similar to 15 m depth. DP logs of the relative dielectric permittivity, the relative hydraulic conductivity, the cone resistance, the sleeve friction and the pore pressure provided crucial data (1) to establish a GPR velocity model for 3-D depth migration and to check the time-to-depth conversion of the GPR data, and (2) to construct a 3-D hydrostratigraphic model. This model was built by assigning porosity values, which were computed from the DP relative dielectric permittivity logs, and DP relative hydraulic conductivity estimates to the identified GPR facies. We conclude that the integration of 3-D GPR structural images and 1-D DP logs of target physical parameters provides an efficient way for detailed 3-D subsurface characterization as needed, for example, for groundwater flow simulations.}, language = {en} } @article{ZeheEhretPfisteretal.2014, author = {Zehe, E. and Ehret, U. and Pfister, L. and Blume, Theresa and Schroeder, Boris and Westhoff, M. and Jackisch, C. and Schymanski, Stanislauv J. and Weiler, M. and Schulz, K. and Allroggen, Niklas and Tronicke, Jens and van Schaik, Loes and Dietrich, Peter and Scherer, U. and Eccard, Jana and Wulfmeyer, Volker and Kleidon, Axel}, title = {HESS Opinions: From response units to functional units: a thermodynamic reinterpretation of the HRU concept to link spatial organization and functioning of intermediate scale catchments}, series = {Hydrology and earth system sciences : HESS}, volume = {18}, journal = {Hydrology and earth system sciences : HESS}, number = {11}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-18-4635-2014}, pages = {4635 -- 4655}, year = {2014}, abstract = {According to Dooge (1986) intermediate-scale catchments are systems of organized complexity, being too organized and yet too small to be characterized on a statistical/conceptual basis, but too large and too heterogeneous to be characterized in a deterministic manner. A key requirement for building structurally adequate models precisely for this intermediate scale is a better understanding of how different forms of spatial organization affect storage and release of water and energy. Here, we propose that a combination of the concept of hydrological response units (HRUs) and thermodynamics offers several helpful and partly novel perspectives for gaining this improved understanding. Our key idea is to define functional similarity based on similarity of the terrestrial controls of gradients and resistance terms controlling the land surface energy balance, rainfall runoff transformation, and groundwater storage and release. This might imply that functional similarity with respect to these specific forms of water release emerges at different scales, namely the small field scale, the hillslope, and the catchment scale. We thus propose three different types of "functional units" - specialized HRUs, so to speak - which behave similarly with respect to one specific form of water release and with a characteristic extent equal to one of those three scale levels. We furthermore discuss an experimental strategy based on exemplary learning and replicate experiments to identify and delineate these functional units, and as a promising strategy for characterizing the interplay and organization of water and energy fluxes across scales. We believe the thermodynamic perspective to be well suited to unmask equifinality as inherent in the equations governing water, momentum, and energy fluxes: this is because several combinations of gradients and resistance terms yield the same mass or energy flux and the terrestrial controls of gradients and resistance terms are largely independent. We propose that structurally adequate models at this scale should consequently disentangle driving gradients and resistance terms, because this optionally allow sequifinality to be partly reduced by including available observations, e. g., on driving gradients. Most importantly, the thermodynamic perspective yields an energy-centered perspective on rainfall-runoff transformation and evapotranspiration, including fundamental limits for energy fluxes associated with these processes. This might additionally reduce equifinality and opens up opportunities for testing thermodynamic optimality principles within independent predictions of rainfall-runoff or land surface energy exchange. This is pivotal to finding out whether or not spatial organization in catchments is in accordance with a fundamental organizing principle.}, language = {en} } @article{WalterLueckBauriegeletal.2015, author = {Walter, Judith and Lueck, Erika and Bauriegel, Albrecht and Richter, C. and Zeitz, Jutta}, title = {Multi-scale analysis of electrical conductivity of peatlands for the assessment of peat properties}, series = {European journal of soil science}, volume = {66}, journal = {European journal of soil science}, number = {4}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1351-0754}, doi = {10.1111/ejss.12251}, pages = {639 -- 650}, year = {2015}, abstract = {Peatlands store large amounts of carbon. This storage function has been reduced through intensive drainage, which leads to the decomposition of peat, resulting in a loss of carbon. Measurements of the real (sigma) and imaginary part (sigma) of electrical conductivity can deliver information on peat properties, such as the pore fluid conductivity (sigma(w)), cation exchange capacity (CEC), bulk density ((b)), water content (WC) and soil organic matter (SOM) content. These properties change with the peat's degree of decomposition (DD). To explore the relationships between the peat properties, sigma, sigma and DD, we focused on three different types of survey and scales. First, point measurements were made with a conductivity probe at various locations over a large area of northeast Germany to determine the degree of correlation between sigma and DD. Second, nine of these locations were selected for sampling to determine which of the properties sigma(w), CEC, (b), WC and SOM predominantly influence sigma and sigma. This multisite dataset includes the entire range of DD and was analysed in the laboratory. Third, one site was selected for a survey of sigma including sampling, to identify which properties mainly control sigma in a single-site approach. Statistical analysis revealed that for the multisite laboratory dataset, sigma(w) has the strongest effect on sigma, followed by CEC, whereas sigma is mainly determined by CEC. In a single-site approach, WC followed by CEC had a dominant effect on sigma. No clear correlation could be observed between (i) DD and peat properties and (ii) DD and sigma or sigma. This is because of the complex changes in properties with increasing DD.}, language = {en} } @misc{RudKaethnerGiesseretal.2018, author = {Rud, R. and K{\"a}thner, Jana and Giesser, J. and Pasche, R. and Giebel, Antje and Selbeck, J{\"o}rn and Shenderey, C. and Fleury, D. and Zude, Manuela and Alchanatis, Victor}, title = {Monitoring spatial variability in an apple orchard under different water regimes}, series = {International Symposium on Sensing Plant Water Status - Methods and Applications in Horticultural Science}, volume = {1197}, journal = {International Symposium on Sensing Plant Water Status - Methods and Applications in Horticultural Science}, publisher = {International Society for Horticultural Science}, address = {The Hague}, isbn = {978-94-62611-93-1}, issn = {0567-7572}, doi = {10.17660/ActaHortic.2018.1197.19}, pages = {139 -- 146}, year = {2018}, abstract = {Precision fruticulture addresses site or tree-adapted crop management. In the present study, soil and tree status, as well as fruit quality at harvest were analysed in a commercial apple (Malus × domestica 'Gala Brookfield'/Pajam1) orchard in a temperate climate. Trees were irrigated in addition to precipitation. Three irrigation levels (0, 50 and 100\%) were applied. Measurements included readings of apparent electrical conductivity of soil (ECa), stem water potential, canopy temperature obtained by infrared camera, and canopy volume estimated by LiDAR and RGB colour imaging. Laboratory analyses of 6 trees per treatment were done on fruit considering the pigment contents and quality parameters. Midday stem water potential (SWP), normalized crop water stress index (CWSI) calculated from thermal data, and fruit yield and quality at harvest were analysed. Spatial patterns of the variability of tree water status were estimated by CWSI imaging supported by SWP readings. CWSI ranged from 0.1 to 0.7 indicating high variability due to irrigation and precipitation. Canopy volume data were less variable. Soil ECa appeared homogeneous in the range of 0 to 4 mS m-1. Fruit harvested in a drought stress zone showed enhanced portion of pheophytin in the chlorophyll pool. Irrigation affected soluble solids content and, hence, the quality of fruit. Overall, results highlighted that spatial variation in orchards can be found even if marginal variability of soil properties can be assumed.}, language = {en} } @article{HeldtDoerfler2021, author = {Heldt, Eugenia C. and D{\"o}rfler, Thomas}, title = {Orchestrating private investors for development}, series = {Regulation \& governance}, volume = {16}, journal = {Regulation \& governance}, number = {4}, publisher = {Wiley-Blackwell}, address = {Hoboken, NJ}, issn = {1748-5983}, doi = {10.1111/rego.12432}, pages = {1382 -- 1398}, year = {2021}, abstract = {Confronted with a new wave of criticism on the in effectiveness of its development programs, the World Bank embarked on a revitalization process, turning to private investors to finance International Development Association projects and widening its mandate. To explain these adaptation strategies of the World Bank to regain relevance, this piece draws on organizational ecology and orchestration scholarship. We contend that international organizations rely on two adaptation mechanisms, orchestration and scope expansion, when they lose their role as focal actors in an issue area. We find that the World Bank has indeed lost market share and has relied on these two mechanisms to revitalize itself. We show that the World Bank responded to changes in the environment by orchestrating a private sector-oriented capital increase, prioritizing private funding for development through a "cascade approach," and expanding the scope of its mandate into adjacent domains of transnational governance, including climate change and global health.}, language = {en} } @article{JiangTaoStolterfohtetal.2020, author = {Jiang, Wei and Tao, Chen and Stolterfoht, Martin and Jin, Hui and Stephen, Meera and Lin, Qianqian and Nagiri, Ravi C. R. and Burn, Paul L. and Gentle, Ian R.}, title = {Hole-transporting materials for low donor content organic solar cells}, series = {Organic electronics : physics, materials and applications}, volume = {76}, journal = {Organic electronics : physics, materials and applications}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1566-1199}, doi = {10.1016/j.orgel.2019.105480}, pages = {7}, year = {2020}, abstract = {Low donor content solar cells are an intriguing class of photovoltaic device about which there is still considerable discussion with respect to their mode of operation. We have synthesized a series of triphenylamine-based materials for use in low donor content devices with the electron accepting [6,6]-phenyl-C71-butyric acid methyl ester (PC(7)0BM). The triphenylamine-based materials absorb light in the near UV enabling the PC(7)0BM to be be the main light absorbing organic semiconducting material in the solar cell. It was found that the devices did not operate as classical Schottky junctions but rather photocurrent was generated by hole transfer from the photo-excited PC(7)0BM to the triphenylamine-based donors. We found that replacing the methoxy surface groups with methyl groups on the donor material led to a decrease in hole mobility for the neat films, which was due to the methyl substituted materials having the propensity to aggregate. The thermodynamic drive to aggregate was advantageous for the performance of the low donor content (6 wt\%) films. It was found that the 6 wt\% donor devices generally gave higher performance than devices containing 50 wt\% of the donor.}, language = {en} } @misc{SchulzeBettBivouretal.2020, author = {Schulze, Patricia S. C. and Bett, Alexander J. and Bivour, Martin and Caprioglio, Pietro and Gerspacher, Fabian M. and Kabakl{\i}, {\"O}zde Ş. and Richter, Armin and Stolterfoht, Martin and Zhang, Qinxin and Neher, Dieter and Hermle, Martin and Hillebrecht, Harald and Glunz, Stefan W. and Goldschmidt, Jan Christoph}, title = {25.1\% high-efficiency monolithic perovskite silicon tandem solar cell with a high bandgap perovskite absorber}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {7}, issn = {1866-8372}, doi = {10.25932/publishup-52566}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-525668}, pages = {12}, year = {2020}, abstract = {Monolithic perovskite silicon tandem solar cells can overcome the theoretical efficiency limit of silicon solar cells. This requires an optimum bandgap, high quantum efficiency, and high stability of the perovskite. Herein, a silicon heterojunction bottom cell is combined with a perovskite top cell, with an optimum bandgap of 1.68 eV in planar p-i-n tandem configuration. A methylammonium-free FA(0.75)Cs(0.25)Pb(I0.8Br0.2)(3) perovskite with high Cs content is investigated for improved stability. A 10\% molarity increase to 1.1 m of the perovskite precursor solution results in approximate to 75 nm thicker absorber layers and 0.7 mA cm(-2) higher short-circuit current density. With the optimized absorber, tandem devices reach a high fill factor of 80\% and up to 25.1\% certified efficiency. The unencapsulated tandem device shows an efficiency improvement of 2.3\% (absolute) over 5 months, showing the robustness of the absorber against degradation. Moreover, a photoluminescence quantum yield analysis reveals that with adapted charge transport materials and surface passivation, along with improved antireflection measures, the high bandgap perovskite absorber has the potential for 30\% tandem efficiency in the near future.}, language = {en} } @article{SchulzeBettBivouretal.2020, author = {Schulze, Patricia S. C. and Bett, Alexander J. and Bivour, Martin and Caprioglio, Pietro and Gerspacher, Fabian M. and Kabakl{\i}, {\"O}zde Ş. and Richter, Armin and Stolterfoht, Martin and Zhang, Qinxin and Neher, Dieter and Hermle, Martin and Hillebrecht, Harald and Glunz, Stefan W. and Goldschmidt, Jan Christoph}, title = {25.1\% high-efficiency monolithic perovskite silicon tandem solar cell with a high bandgap perovskite absorber}, series = {Solar RRL}, volume = {4}, journal = {Solar RRL}, number = {7}, publisher = {John Wiley \& Sons, Inc.}, address = {New Jersey}, pages = {10}, year = {2020}, abstract = {Monolithic perovskite silicon tandem solar cells can overcome the theoretical efficiency limit of silicon solar cells. This requires an optimum bandgap, high quantum efficiency, and high stability of the perovskite. Herein, a silicon heterojunction bottom cell is combined with a perovskite top cell, with an optimum bandgap of 1.68 eV in planar p-i-n tandem configuration. A methylammonium-free FA(0.75)Cs(0.25)Pb(I0.8Br0.2)(3) perovskite with high Cs content is investigated for improved stability. A 10\% molarity increase to 1.1 m of the perovskite precursor solution results in approximate to 75 nm thicker absorber layers and 0.7 mA cm(-2) higher short-circuit current density. With the optimized absorber, tandem devices reach a high fill factor of 80\% and up to 25.1\% certified efficiency. The unencapsulated tandem device shows an efficiency improvement of 2.3\% (absolute) over 5 months, showing the robustness of the absorber against degradation. Moreover, a photoluminescence quantum yield analysis reveals that with adapted charge transport materials and surface passivation, along with improved antireflection measures, the high bandgap perovskite absorber has the potential for 30\% tandem efficiency in the near future.}, language = {en} } @article{SchenckWetzel2022, author = {Schenck, Marcia C. and Wetzel, Johanna M.}, title = {Shifting the means of (knowledge) production}, series = {World history connected : the ejournal of learning and teaching ; WHC}, volume = {19}, journal = {World history connected : the ejournal of learning and teaching ; WHC}, number = {3}, issn = {1931-8642}, doi = {10.13021/whc.v19i3.3327}, pages = {39}, year = {2022}, language = {en} } @article{BalciAkkayaAkyuzetal.2016, author = {Balci, K. and Akkaya, Y. and Akyuz, S. and Collier, W. B. and Stricker, M. C. and Stover, D. D. and Ritzhaupt, G. and Koch, Andreas and Kleinpeter, Erich}, title = {The effects of conformation and zwitterionic tautomerism on the structural and vibrational spectral data of anserine}, series = {Vibrational spectroscopy : an international journal devoted to applications of infrared and raman spectroscopy}, volume = {86}, journal = {Vibrational spectroscopy : an international journal devoted to applications of infrared and raman spectroscopy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-2031}, doi = {10.1016/j.vibspec.2016.08.003}, pages = {277 -- 289}, year = {2016}, abstract = {In this study, the stable conformers of neutral anserine were searched by molecular dynamics simulations and energy minimization calculations using the MM2 force field. Thermochemical calculations at B3LYP/6-31G(d) level of theory followed these preliminary calculations. The results confirmed that neutral anserine has quite a flexible structure and many stable gauche and trans conformers at room temperature. Nevertheless, two are considerably more favourable in energy than the others and expected to dominate the gas-phase and matrix IR spectra of the molecule. The corresponding structural and vibrational spectral data for these two conformers of neutral anserine, whose relative stabilities were also examined by high-accuracy energy calculations carried out using G3MP2B3 method, and for the most stable conformer of anserine in zwitterion form were calculated at B3LYP/6-311++G(d,p) level of theory. The calculated harmonic force constants were refined using the Scaled Quantum Mechanical Force Field (SQM-FF) method and then used to produce the refined wavenumbers, potential energy distributions (PEDs) and IR and Raman intensities. These refined data together with the scaled harmonic wavenumbers obtained using another method, Dual Scale factors (DS), enabled us to correctly analyse the observed IR and Raman spectra of anserine and revealed the effects of conformation and zwitterionic tautomerism on its structural and vibrational spectral data. (C) 2016 Elsevier B.V. All rights reserved.}, language = {en} } @misc{HirschmuellerBaurBraunetal.2017, author = {Hirschmueller, Anja and Baur, Heiner and Braun, Sepp and Kreuz, Peter C. and Suedkamp, Norbert P and Niemeyer, Philipp}, title = {Rehabilitation after autologous chondrocyte implantation for isolated cartilage defects of the knee}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-403170}, pages = {11}, year = {2017}, abstract = {Autologous chondrocyte implantation for treatment of isolated cartilage defects of the knee has become well established. Although various publications report technical modifications, clinical results, and cell-related issues, little is known about appropriate and optimal rehabilitation after autologous chondrocyte implantation. This article reviews the literature on rehabilitation after autologous chondrocyte implantation and presents a rehabilitation protocol that has been developed considering the best available evidence and has been successfully used for several years in a large number of patients who underwent autologous chondrocyte implantation for cartilage defects of the knee.}, language = {en} } @article{MartinezValdesLaineFallaetal.2016, author = {Martinez-Valdes, Eduardo Andr{\´e}s and Laine, C. M. and Falla, D. and Mayer, Frank and Farina, D.}, title = {High-density surface electromyography provides reliable estimates of motor unit behavior}, series = {Clinical neurophysiology}, volume = {127}, journal = {Clinical neurophysiology}, publisher = {Elsevier}, address = {Clare}, issn = {1388-2457}, doi = {10.1016/j.clinph.2015.10.065}, pages = {2534 -- 2541}, year = {2016}, abstract = {Objective: To assess the intra-and inter-session reliability of estimates of motor unit behavior and muscle fiber properties derived from high-density surface electromyography (HDEMG). Methods: Ten healthy subjects performed submaximal isometric knee extensions during three recording sessions (separate days) at 10\%, 30\%, 50\% and 70\% of their maximum voluntary effort. The discharge timings of motor units of the vastus lateralis and medialis muscles were automatically identified from HDEMG by a decomposition algorithm. We characterized the number of detected motor units, their discharge rates, the coefficient of variation of their inter-spike intervals (CoVisi), the action potential conduction velocity and peak-to-peak amplitude. Reliability was assessed for each motor unit characteristics by intra-class correlation coefficient (ICC). Additionally, a pulse-to-noise ratio (PNR) was calculated, to verify the accuracy of the decomposition. Results: Good to excellent reliability within and between sessions was found for all motor unit characteristics at all force levels (ICCs > 0.8), with the exception of CoVisi that presented poor reliability (ICC < 0.6). PNR was high and similar for both muscles with values ranging between 45.1 and 47.6 dB (accuracy > 95\%). Conclusion: Motor unit features can be assessed non-invasively and reliably within and across sessions over a wide range of force levels. Significance: These results suggest that it is possible to characterize motor units in longitudinal intervention studies. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.}, language = {en} } @article{ShraderHamaguchiSturneretal.2015, author = {Shrader, C. R. and Hamaguchi, K. and Sturner, Steven J. and Oskinova, Lida and Almeyda, T. and Petre, R.}, title = {Hifg-energy properties of the enigmatic be STAR gamma Cassiopeiae}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {799}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/799/1/84}, pages = {10}, year = {2015}, abstract = {We present the results of a broadband X-ray study of the enigmatic Be star Gamma Cassiopeiae (herein gamma Cas) based on observations made with both the Suzaku and INTEGRAL observatories.. Cas has long been recognized as the prototypical example of a small subclass of Be stars with moderately strong X-ray emission dominated by a hot thermal component in the 0.5-12 keV energy range (L-x approximate to 10(32)-10(33) erg s(-1)). This places them at the high end of the known luminosity distribution for stellar emission, but several orders of magnitude below typical accretion-powered Be X-ray binaries. The INTEGRAL observations spanned an eight-year baseline and represent the deepest measurement to date at energies above similar to 50 keV. We find that the INTEGRAL data are consistent within statistics to a constant intensity source above 20 keV, with emission extending up to similar to 100 keV, and that searches for all of the previously reported periodicities of the system at lower energies led to null results. We further find that our combined Suzaku and INTEGRAL spectrum, which we suggest is the most accurate broadband X-ray measurement of gamma Cas to date, is fitted extremely well with a thermal plasma emission model with a single absorption component. We found no compelling need for an additional non-thermal high-energy component. We discuss these results in the context of a currently favored models for gamma Cas and its analogs.}, language = {en} } @article{RosaPohlenzdeGrouchyetal.2016, author = {Rosa, Angelika D. and Pohlenz, Julia and de Grouchy, C. and Cochain, B. and Kono, Y. and Pasternak, S. and Mathon, O. and Irifune, Tetsuo and Wilke, Max}, title = {In situ characterization of liquid network structures at high pressure and temperature using X-ray absorption spectroscopy coupled with the Paris-Edinburgh press}, series = {High pressure research}, volume = {36}, journal = {High pressure research}, publisher = {American Geophysical Union}, address = {Abingdon}, issn = {0895-7959}, doi = {10.1080/08957959.2016.1199693}, pages = {332 -- 347}, year = {2016}, abstract = {We review recent progress in studying structural properties of liquids using X-ray absorption spectroscopy coupled with the Paris-Edinburgh press at third-generation synchrotron facilities. This experimental method allows for detecting subtle changes in atomic arrangements of melts over a wide pressure-temperature range. It has been also employed to monitor variations of the local coordination environment of diluted species contained in glasses, liquids and crystalline phases as a function of the pressure and temperature. Such information is of great importance for gaining deeper insights into the physico-chemical properties of liquids at extreme condition, including the understanding of such phenomena as liquid-liquid phase transitions, viscosity drops and various transport properties of geological melts. Here, we describe the experimental approach and discuss its potential in structural characterization on selected scientific highlights. Finally, the current ongoing instrumental developments and future scientific opportunities are discussed.}, language = {en} } @article{CabiecesOlivar‐CastanoJunqueiraetal.2022, author = {Cabieces, Roberto and Olivar-Casta{\~n}o, Andr{\´e}s and Junqueira, Thiago C. and Relinque, Jes{\´u}s and Fernandez-Prieto, Luis M. and Vack{\´a}r, Jiř{\´i} and R{\"o}sler, Boris and Barco, Jaime and Pazos, Antonio and Garc{\´i}a-Mart{\´i}nez, Luz}, title = {Integrated Seismic Program (ISP): A new Python GUI-based software for earthquake seismology and seismic signal processing}, series = {Seismological research letters}, volume = {93}, journal = {Seismological research letters}, number = {3}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0895-0695}, doi = {10.1785/0220210205}, pages = {1895 -- 1908}, year = {2022}, abstract = {Integrated Seismic Program (ISP) is a graphical user interface designed to facilitate and provide a user-friendly framework for performing diverse common and advanced tasks in seismological research. ISP is composed of five main modules for earthquake location, time-frequency analysis and advanced signal processing, implementation of array techniques to estimate the slowness vector, seismic moment tensor inversion, and receiver function computation and analysis. In addition, several support tools are available, allowing the user to create an event database, download data from International Federation of Digital Seismograph Networks services, inspect the background noise, and compute synthetic seismograms. ISP is written in Python3, supported by several open-source and/or publicly available tools. Its modular design allows for new features to be added in a collaborative development environment.}, language = {en} } @article{DoebbelingHildebrandtMierschKhannaetal.2024, author = {D{\"o}bbeling-Hildebrandt, Niklas and Miersch, Klaas and Khanna, Tarun M. and Bachelet, Marion and Bruns, Stephan B. and Callaghan, Max and Edenhofer, Ottmar and Flachsland, Christian and Forster, Piers M. and Kalkuhl, Matthias and Koch, Nicolas and Lamb, William F. and Ohlendorf, Nils and Steckel, Jan Christoph and Minx, Jan C.}, title = {Systematic review and meta-analysis of ex-post evaluations on the effectiveness of carbon pricing}, series = {Nature communications}, volume = {15}, journal = {Nature communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-024-48512-w}, pages = {12}, year = {2024}, abstract = {Today, more than 70 carbon pricing schemes have been implemented around the globe, but their contributions to emissions reductions remains a subject of heated debate in science and policy. Here we assess the effectiveness of carbon pricing in reducing emissions using a rigorous, machine-learning assisted systematic review and meta-analysis. Based on 483 effect sizes extracted from 80 causal ex-post evaluations across 21 carbon pricing schemes, we find that introducing a carbon price has yielded immediate and substantial emission reductions for at least 17 of these policies, despite the low level of prices in most instances. Statistically significant emissions reductions range between -5\% to -21\% across the schemes (-4\% to -15\% after correcting for publication bias). Our study highlights critical evidence gaps with regard to dozens of unevaluated carbon pricing schemes and the price elasticity of emissions reductions. More rigorous synthesis of carbon pricing and other climate policies is required across a range of outcomes to advance our understanding of "what works" and accelerate learning on climate solutions in science and policy.}, language = {en} } @book{Schenck2022, author = {Schenck, Marcia C.}, title = {Remembering African Labor Migration to the Second World}, series = {Palgrave Macmillan Transnational History Series}, journal = {Palgrave Macmillan Transnational History Series}, publisher = {Palgrave Macmillan}, address = {Cham}, isbn = {978-3-031-06775-4}, issn = {2634-6273}, doi = {10.1007/978-3-031-06776-1}, pages = {XXVII, 377}, year = {2022}, abstract = {This open access book is about Mozambicans and Angolans who migrated in state-sponsored schemes to East Germany in the late 1970s and throughout the 1980s. They went to work and to be trained as a vanguard labor force for the intended African industrial revolutions. While they were there, they contributed their labor power to the East German economy.  This book draws on more than 260 life history interviews and uncovers complex and contradictory experiences and transnational encounters. What emerges is a series of dualities that exist side by side in the memories of the former migrants: the state and the individual, work and consumption, integration and exclusion, loss and gain, and the past in the past and the past in the present and future. By uncovering these dualities, the book explores the lives of African migrants moving between the Third and Second worlds.  Devoted to the memories of worker-trainees, this transnational study comes at a time when historians are uncovering the many varied, complicated, and important connections within the global socialist world.}, language = {en} } @misc{Haenel2021, author = {H{\"a}nel, Hilkje C.}, title = {The intricacies of ideology and ignorance}, series = {Social epistemology review \& reply collective : SERRC}, volume = {10}, journal = {Social epistemology review \& reply collective : SERRC}, number = {7}, publisher = {Social epistemology review \& reply collective}, address = {[Erscheinungsort nicht ermittelbar]}, issn = {2471-9560}, pages = {58 -- 62}, year = {2021}, language = {en} } @article{BarbosaCoelhoGusmaoetal.2022, author = {Barbosa, Luis Romero A. and Coelho, Victor Hugo R. and Gusmao, Ana Claudia V. L. F. and Fernandes, Lucila A. E. and da Silva, Bernardo B. and Galvao, Carlos de O. and Caicedo, Nelson O. L. and da Paz, Adriano R. and Xuan, Yunqing and Bertrand, Guillaume F. and Melo, Davi de C. D. and Montenegro, Suzana M. G. L. and Oswald, Sascha and Almeida, Cristiano das N.}, title = {A satellite-based approach to estimating spatially distributed groundwater recharge rates in a tropical wet sedimentary region despite cloudy conditions}, series = {Journal of hydrology}, volume = {607}, journal = {Journal of hydrology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2022.127503}, pages = {15}, year = {2022}, abstract = {Groundwater recharge (GWR) is one of the most challenging water fluxes to estimate, as it relies on observed data that are often limited in many developing countries. This study developed an innovative water budget method using satellite products for estimating the spatially distributed GWR at monthly and annual scales in tropical wet sedimentary regions despite cloudy conditions. The distinctive features proposed in this study include the capacity to address 1) evapotranspiration estimations in tropical wet regions frequently overlaid by substantial cloud cover; and 2) seasonal root-zone water storage estimations in sedimentary regions prone to monthly variations. The method also utilises satellite-based information of the precipitation and surface runoff. The GWR was estimated and validated for the hydrologically contrasting years 2016 and 2017 over a tropical wet sedimentary region located in North-eastern Brazil, which has substantial potential for groundwater abstraction. This study showed that applying a cloud-cleaning procedure based on monthly compositions of biophysical data enables the production of a reasonable proxy for evapotranspiration able to estimate groundwater by the water budget method. The resulting GWR rates were 219 (2016) and 302 (2017) mm yr(-1), showing good correlations (CC = 0.68 to 0.83) and slight underestimations (PBIAS =-13 to-9\%) when compared with the referenced estimates obtained by the water table fluctuation method for 23 monitoring wells. Sensitivity analysis shows that water storage changes account for +19\% to-22\% of our monthly evaluation. The satellite-based approach consistently demonstrated that the consideration of cloud-cleaned evapotranspiration and root-zone soil water storage changes are essential for a proper estimation of spatially distributed GWR in tropical wet sedimentary regions because of their weather seasonality and cloudy conditions.}, language = {en} } @unpublished{AsendorpfConnerDeFruytetal.2013, author = {Asendorpf, Jens B. and Conner, Mark and De Fruyt, Filip and De Houwer, Jan and Denissen, Jaap J. A. and Fiedler, Klaus and Fiedler, Susann and Funder, David C. and Kliegl, Reinhold and Nosek, Brian A. and Perugini, Marco and Roberts, Brent W. and Schmitt, Manfred and Van Aken, Marcel A. G. and Weber, Hannelore and Wicherts, Jelte M.}, title = {Replication is more than hitting the lottery twice}, series = {European journal of personality}, volume = {27}, journal = {European journal of personality}, number = {2}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0890-2070}, pages = {138 -- 144}, year = {2013}, abstract = {The main goal of our target article was to provide concrete recommendations for improving the replicability of research findings. Most of the comments focus on this point. In addition, a few comments were concerned with the distinction between replicability and generalizability and the role of theory in replication. We address all comments within the conceptual structure of the target article and hope to convince readers that replication in psychological science amounts to much more than hitting the lottery twice.}, language = {en} } @article{AsendorpfConnerDeFruytetal.2013, author = {Asendorpf, Jens B. and Conner, Mark and De Fruyt, Filip and De Houwer, Jan and Denissen, Jaap J. A. and Fiedler, Klaus and Fiedler, Susann and Funder, David C. and Kliegl, Reinhold and Nosek, Brian A. and Perugini, Marco and Roberts, Brent W. and Schmitt, Manfred and vanAken, Marcel A. G. and Weber, Hannelore and Wicherts, Jelte M.}, title = {Recommendations for increasing replicability in psychology}, series = {European journal of personality}, volume = {27}, journal = {European journal of personality}, number = {2}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0890-2070}, doi = {10.1002/per.1919}, pages = {108 -- 119}, year = {2013}, abstract = {Replicability of findings is at the heart of any empirical science. The aim of this article is to move the current replicability debate in psychology towards concrete recommendations for improvement. We focus on research practices but also offer guidelines for reviewers, editors, journal management, teachers, granting institutions, and university promotion committees, highlighting some of the emerging and existing practical solutions that can facilitate implementation of these recommendations. The challenges for improving replicability in psychological science are systemic. Improvement can occur only if changes are made at many levels of practice, evaluation, and reward.}, language = {en} } @article{LupienRussellPearsonetal.2022, author = {Lupien, Rachel L. and Russell, James M. and Pearson, Emma J. and Castaneda, Isla S. and Asrat, Asfawossen and F{\"o}rster, Verena and Lamb, Henry F. and Roberts, Helen M. and Sch{\"a}bitz, Frank and Trauth, Martin H. and Beck, Catherine C. and Feibel, Craig S. and Cohen, Andrew S.}, title = {Orbital controls on eastern African hydroclimate in the Pleistocene}, series = {Scientific reports}, volume = {12}, journal = {Scientific reports}, number = {1}, publisher = {Macmillan Publishers Limited}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-022-06826-z}, pages = {10}, year = {2022}, abstract = {Understanding eastern African paleoclimate is critical for contextualizing early human evolution, adaptation, and dispersal, yet Pleistocene climate of this region and its governing mechanisms remain poorly understood due to the lack of long, orbitally-resolved, terrestrial paleoclimate records. Here we present leaf wax hydrogen isotope records of rainfall from paleolake sediment cores from key time windows that resolve long-term trends, variations, and high-latitude effects on tropical African precipitation. Eastern African rainfall was dominantly controlled by variations in low-latitude summer insolation during most of the early and middle Pleistocene, with little evidence that glacial-interglacial cycles impacted rainfall until the late Pleistocene. We observe the influence of high-latitude-driven climate processes emerging from the last interglacial (Marine Isotope Stage 5) to the present, an interval when glacial-interglacial cycles were strong and insolation forcing was weak. Our results demonstrate a variable response of eastern African rainfall to low-latitude insolation forcing and high-latitude-driven climate change, likely related to the relative strengths of these forcings through time and a threshold in monsoon sensitivity. We observe little difference in mean rainfall between the early, middle, and late Pleistocene, which suggests that orbitally-driven climate variations likely played a more significant role than gradual change in the relationship between early humans and their environment.}, language = {en} } @book{ZhangPlauthEberhardtetal.2020, author = {Zhang, Shuhao and Plauth, Max and Eberhardt, Felix and Polze, Andreas and Lehmann, Jens and Sejdiu, Gezim and Jabeen, Hajira and Servadei, Lorenzo and M{\"o}stl, Christian and B{\"a}r, Florian and Netzeband, Andr{\´e} and Schmidt, Rainer and Knigge, Marlene and Hecht, Sonja and Prifti, Loina and Krcmar, Helmut and Sapegin, Andrey and Jaeger, David and Cheng, Feng and Meinel, Christoph and Friedrich, Tobias and Rothenberger, Ralf and Sutton, Andrew M. and Sidorova, Julia A. and Lundberg, Lars and Rosander, Oliver and Sk{\"o}ld, Lars and Di Varano, Igor and van der Walt, Est{\´e}e and Eloff, Jan H. P. and Fabian, Benjamin and Baumann, Annika and Ermakova, Tatiana and Kelkel, Stefan and Choudhary, Yash and Cooray, Thilini and Rodr{\´i}guez, Jorge and Medina-P{\´e}rez, Miguel Angel and Trejo, Luis A. and Barrera-Animas, Ari Yair and Monroy-Borja, Ra{\´u}l and L{\´o}pez-Cuevas, Armando and Ram{\´i}rez-M{\´a}rquez, Jos{\´e} Emmanuel and Grohmann, Maria and Niederleithinger, Ernst and Podapati, Sasidhar and Schmidt, Christopher and Huegle, Johannes and de Oliveira, Roberto C. L. and Soares, F{\´a}bio Mendes and van Hoorn, Andr{\´e} and Neumer, Tamas and Willnecker, Felix and Wilhelm, Mathias and Kuster, Bernhard}, title = {HPI Future SOC Lab - Proceedings 2017}, number = {130}, editor = {Meinel, Christoph and Polze, Andreas and Beins, Karsten and Strotmann, Rolf and Seibold, Ulrich and R{\"o}dszus, Kurt and M{\"u}ller, J{\"u}rgen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-475-3}, issn = {1613-5652}, doi = {10.25932/publishup-43310}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-433100}, publisher = {Universit{\"a}t Potsdam}, pages = {ix, 235}, year = {2020}, abstract = {The "HPI Future SOC Lab" is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2017. Selected projects have presented their results on April 25th and November 15th 2017 at the Future SOC Lab Day events.}, language = {en} } @article{HempelSavenjieStolterfohtetal.2022, author = {Hempel, Hannes and Savenjie, Tom J. and Stolterfoht, Martin and Neu, Jens and Failla, Michele and Paingad, Vaisakh C. and Kužel, Petr and Heilweil, Edwin J. and Spies, Jacob A. and Schleuning, Markus and Zhao, Jiashang and Friedrich, Dennis and Schwarzburg, Klaus and Siebbeles, Laurens D. A. and D{\"o}rflinger, Patrick and Dyakonov, Vladimir and Katoh, Ryuzi and Hong, Min Ji and Labram, John G. and Monti, Maurizio and Butler-Caddle, Edward and Lloyd-Hughes, James and Taheri, Mohammad M. and Baxter, Jason B. and Magnanelli, Timothy J. and Luo, Simon and Cardon, Joseph M. and Ardo, Shane and Unold, Thomas}, title = {Predicting solar cell performance from terahertz and microwave spectroscopy}, series = {Advanced energy materials}, volume = {12}, journal = {Advanced energy materials}, number = {13}, publisher = {Wiley}, address = {Weinheim}, issn = {1614-6832}, doi = {10.1002/aenm.202102776}, pages = {16}, year = {2022}, abstract = {Mobilities and lifetimes of photogenerated charge carriers are core properties of photovoltaic materials and can both be characterized by contactless terahertz or microwave measurements. Here, the expertise from fifteen laboratories is combined to quantitatively model the current-voltage characteristics of a solar cell from such measurements. To this end, the impact of measurement conditions, alternate interpretations, and experimental inter-laboratory variations are discussed using a (Cs,FA,MA)Pb(I,Br)(3) halide perovskite thin-film as a case study. At 1 sun equivalent excitation, neither transport nor recombination is significantly affected by exciton formation or trapping. Terahertz, microwave, and photoluminescence transients for the neat material yield consistent effective lifetimes implying a resistance-free JV-curve with a potential power conversion efficiency of 24.6 \%. For grainsizes above approximate to 20 nm, intra-grain charge transport is characterized by terahertz sum mobilities of approximate to 32 cm(2) V-1 s(-1). Drift-diffusion simulations indicate that these intra-grain mobilities can slightly reduce the fill factor of perovskite solar cells to 0.82, in accordance with the best-realized devices in the literature. Beyond perovskites, this work can guide a highly predictive characterization of any emerging semiconductor for photovoltaic or photoelectrochemical energy conversion. A best practice for the interpretation of terahertz and microwave measurements on photovoltaic materials is presented.}, language = {en} } @article{BiermannNowakBraunetal.2024, author = {Biermann, Kaija and Nowak, Bianca and Braun, Lea-Marie and Taddicken, Monika and Kr{\"a}mer, Nicole C. and Stieglitz, Stefan}, title = {Does scientific evidence sell?}, series = {Science communication}, volume = {0}, journal = {Science communication}, publisher = {Sage}, address = {Thousand Oaks, Calif.}, issn = {1075-5470}, doi = {10.1177/10755470241249468}, pages = {34}, year = {2024}, abstract = {Examining the dissemination of evidence on social media, we analyzed the discourse around eight visible scientists in the context of COVID-19. Using manual (N = 1,406) and automated coding (N = 42,640) on an account-based tracked Twitter/X dataset capturing scientists' activities and eliciting reactions over six 2-week periods, we found that visible scientists' tweets included more scientific evidence. However, public reactions contained more anecdotal evidence. Findings indicate that evidence can be a message characteristic leading to greater tweet dissemination. Implications for scientists, including explicitly incorporating scientific evidence in their communication and examining evidence in science communication research, are discussed.}, language = {en} } @article{KupferBauervanRoesteletal.2022, author = {Kupfer, Thomas and Bauer, Evan B. and van Roestel, Jan and Bellm, Eric C. and Bildsten, Lars and Fuller, Jim and Prince, Thomas A. and Heber, Ulrich and Geier, Stephan and Green, Matthew J. and Kulkarni, Shrinivas R. and Bloemen, Steven and Laher, Russ R. and Rusholme, Ben and Schneider, David}, title = {Discovery of a Double-detonation Thermonuclear Supernova Progenitor}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, volume = {925}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2041-8205}, doi = {10.3847/2041-8213/ac48f1}, pages = {10}, year = {2022}, abstract = {We present the discovery of a new double-detonation progenitor system consisting of a hot subdwarf B (sdB) binary with a white dwarf companion with a P (orb) = 76.34179(2) minutes orbital period. Spectroscopic observations are consistent with an sdB star during helium core burning residing on the extreme horizontal branch. Chimera light curves are dominated by ellipsoidal deformation of the sdB star and a weak eclipse of the companion white dwarf. Combining spectroscopic and light curve fits, we find a low-mass sdB star, M (sdB) = 0.383 +/- 0.028 M (circle dot) with a massive white dwarf companion, M (WD) = 0.725 +/- 0.026 M (circle dot). From the eclipses we find a blackbody temperature for the white dwarf of 26,800 K resulting in a cooling age of approximate to 25 Myr whereas our MESA model predicts an sdB age of approximate to 170 Myr. We conclude that the sdB formed first through stable mass transfer followed by a common envelope which led to the formation of the white dwarf companion approximate to 25 Myr ago. Using the MESA stellar evolutionary code we find that the sdB star will start mass transfer in approximate to 6 Myr and in approximate to 60 Myr the white dwarf will reach a total mass of 0.92 M (circle dot) with a thick helium layer of 0.17 M (circle dot). This will lead to a detonation that will likely destroy the white dwarf in a peculiar thermonuclear supernova. PTF1 J2238+7430 is only the second confirmed candidate for a double-detonation thermonuclear supernova. Using both systems we estimate that at least approximate to 1\% of white dwarf thermonuclear supernovae originate from sdB+WD binaries with thick helium layers, consistent with the small number of observed peculiar thermonuclear explosions.}, language = {en} } @misc{SaidiZouhalRhibietal.2019, author = {Saidi, Karim and Zouhal, Hassane and Rhibi, Fatma and Tijani, Jed M. and Boullosa, Daniel and Chebbi, Amel and Hackney, Anthony C. and Granacher, Urs and Bideau, Benoit and Ben Abderrahman, Abderraouf}, title = {Effects of a six-week period of congested match play on plasma volume variations, hematological parameters, training workload and physical fitness in elite soccer players}, series = {Postprints der Universit{\"a}t Potsdam Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam Humanwissenschaftliche Reihe}, number = {572}, issn = {1866-8364}, doi = {10.25932/publishup-43716}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-437166}, pages = {17}, year = {2019}, abstract = {Objectives The aims of this study were to investigate the effects of a six-week in-season period of soccer training and games (congested period) on plasma volume variations (PV), hematological parameters, and physical fitness in elite players. In addition, we analyzed relationships between training load, hematological parameters and players' physical fitness. Methods Eighteen elite players were evaluated before (T1) and after (T2) a six-week in-season period interspersed with 10 soccer matches. At T1 and T2, players performed the Yo-Yo intermittent recovery test level 1 (YYIR1), the repeated shuttle sprint ability test (RSSA), the countermovement jump test (CMJ), and the squat jump test (SJ). In addition, PV and hematological parameters (erythrocytes [M/mm3], hematocrit [\%], hemoglobin [g/dl], mean corpuscular volume [fl], mean corpuscular hemoglobin content [pg], and mean hemoglobin concentration [\%]) were assessed. Daily ratings of perceived exertion (RPE) were monitored in order to quantify the internal training load. Results From T1 to T2, significant performance declines were found for the YYIR1 (p<0.001, effect size [ES] = 0.5), RSSA (p<0.01, ES = 0.6) and SJ tests (p< 0.046, ES = 0.7). However, no significant changes were found for the CMJ (p = 0.86, ES = 0.1). Post-exercise, RSSA blood lactate (p<0.012, ES = 0.2) and PV (p<0.01, ES = 0.7) increased significantly from T1 to T2. A significant decrease was found from T1 to T2 for the erythrocyte value (p<0.002, ES = 0.5) and the hemoglobin concentration (p<0.018, ES = 0.8). The hematocrit percentage rate was also significantly lower (p<0.001, ES = 0.6) at T2. The mean corpuscular volume, mean corpuscular hemoglobin content and the mean hemoglobin content values were not statistically different from T1 to T2. No significant relationships were detected between training load parameters and percentage changes of hematological parameters. However, a significant relationship was observed between training load and changes in RSSA performance (r = -0.60; p<0.003). Conclusions An intensive period of "congested match play" over 6 weeks significantly compromised players' physical fitness. These changes were not related to hematological parameters, even though significant alterations were detected for selected measures.}, language = {en} } @article{SaidiZouhalRhibietal.2019, author = {Saidi, Karim and Zouhal, Hassane and Rhibi, Fatma and Tijani, Jed M. and Boullosa, Daniel and Chebbi, Amel and Hackney, Anthony C. and Granacher, Urs and Bideau, Benoit and Ben Abderrahman, Abderraouf}, title = {Effects of a six-week period of congested match play on plasma volume variations, hematological parameters, training workload and physical fitness in elite soccer players}, series = {PLOS ONE}, volume = {14}, journal = {PLOS ONE}, number = {7}, publisher = {Public Library of Science}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0219692}, pages = {17}, year = {2019}, abstract = {Objectives The aims of this study were to investigate the effects of a six-week in-season period of soccer training and games (congested period) on plasma volume variations (PV), hematological parameters, and physical fitness in elite players. In addition, we analyzed relationships between training load, hematological parameters and players' physical fitness. Methods Eighteen elite players were evaluated before (T1) and after (T2) a six-week in-season period interspersed with 10 soccer matches. At T1 and T2, players performed the Yo-Yo intermittent recovery test level 1 (YYIR1), the repeated shuttle sprint ability test (RSSA), the countermovement jump test (CMJ), and the squat jump test (SJ). In addition, PV and hematological parameters (erythrocytes [M/mm3], hematocrit [\%], hemoglobin [g/dl], mean corpuscular volume [fl], mean corpuscular hemoglobin content [pg], and mean hemoglobin concentration [\%]) were assessed. Daily ratings of perceived exertion (RPE) were monitored in order to quantify the internal training load. Results From T1 to T2, significant performance declines were found for the YYIR1 (p<0.001, effect size [ES] = 0.5), RSSA (p<0.01, ES = 0.6) and SJ tests (p< 0.046, ES = 0.7). However, no significant changes were found for the CMJ (p = 0.86, ES = 0.1). Post-exercise, RSSA blood lactate (p<0.012, ES = 0.2) and PV (p<0.01, ES = 0.7) increased significantly from T1 to T2. A significant decrease was found from T1 to T2 for the erythrocyte value (p<0.002, ES = 0.5) and the hemoglobin concentration (p<0.018, ES = 0.8). The hematocrit percentage rate was also significantly lower (p<0.001, ES = 0.6) at T2. The mean corpuscular volume, mean corpuscular hemoglobin content and the mean hemoglobin content values were not statistically different from T1 to T2. No significant relationships were detected between training load parameters and percentage changes of hematological parameters. However, a significant relationship was observed between training load and changes in RSSA performance (r = -0.60; p<0.003). Conclusions An intensive period of "congested match play" over 6 weeks significantly compromised players' physical fitness. These changes were not related to hematological parameters, even though significant alterations were detected for selected measures.}, language = {en} } @article{IurchukSchickBranetal.2016, author = {Iurchuk, V. and Schick, D. and Bran, J. and Colson, D. and Forget, A. and Halley, D. and Koc, Azize and Reinhardt, Mathias and Kwamen, C. and Morley, N. A. and Bargheer, Matias and Viret, M. and Gumeniuk, R. and Schmerber, G. and Doudin, B. and Kundys, B.}, title = {Optical Writing of Magnetic Properties by Remanent Photostriction}, series = {Physical review letters}, volume = {117}, journal = {Physical review letters}, publisher = {American Physical Society}, address = {College Park}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.117.107403}, pages = {5}, year = {2016}, abstract = {We present an optically induced remanent photostriction in BiFeO3, resulting from the photovoltaic effect, which is used to modify the ferromagnetism of Ni film in a hybrid BiFeO3/Ni structure. The 75\% change in coercivity in the Ni film is achieved via optical and nonvolatile control. This photoferromagnetic effect can be reversed by static or ac electric depolarization of BiFeO3. Hence, the strain dependent changes in magnetic properties are written optically, and erased electrically. Light-mediated straintronics is therefore a possible approach for low-power multistate control of magnetic elements relevant for memory and spintronic applications.}, language = {en} } @article{RonquilloHankeGogokhiaReveloetal.2016, author = {Ronquillo, Cecinio C. and Hanke-Gogokhia, Christin and Revelo, Monica P. and Frederick, Jeanne M. and Jiang, Li and Baehr, Wolfgang}, title = {Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation}, series = {The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology}, volume = {30}, journal = {The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology}, publisher = {Federation of American Societies for Experimental Biology}, address = {Bethesda}, issn = {0892-6638}, doi = {10.1096/fj.201600511R}, pages = {3400 -- 3412}, year = {2016}, abstract = {Null mutations in the human IQCB1/NPHP5 (nephrocystin-5) gene that encodes NPHP5 are the most frequent cause of Senior-LOken syndrome, a ciliopathy that is characterized by Leber congenital amaurosis and nephronophthisis. We generated germline Nphp5-knockout mice by placing a -Geo gene trap in intron 4, thereby truncating NPHP5 at Leu87 and removing all known functional domains. At eye opening, Nphp5(-/-) mice exhibited absence of scotopic and photopic electroretinogram responses, a phenotype that resembles Leber congenital amaurosis. Outer segment transmembrane protein accumulation in Nphp5(-/-) endoplasmic reticulum was evident as early as postnatal day (P)6. EGFP-CETN2, a centrosome and transition zone marker, identified basal bodies in Nphp5(-/-) photoreceptors, but without fully developed transition zones. Ultrastructure of P6 and 10 Nphp5(-/-) photoreceptors revealed aberrant transition zones of reduced diameter. Nphp5(-/-) photoreceptor degeneration was complete at 1 mo of age but was delayed significantly in Nphp5(-/-);Nrl(-/-) (cone only) retina. Nphp5(-/-) mouse embryonic fibroblast developed normal cilia, and Nphp5(-/-) kidney histology at 1 yr of age showed no significant pathology. Results establish that nephrocystin-5 is essential for photoreceptor outer segment formation but is dispensable for kidney and mouse embryonic fibroblast ciliary formation.}, language = {en} } @article{JebabliZouhalBoullosaetal.2022, author = {Jebabli, Nidhal and Zouhal, Hassane and Boullosa, Daniel and Govindasamy, Karuppasamy and Tourny, Claire and Hackney, Anthony C. and Granacher, Urs and Ben Abderrahman, Abderraouf}, title = {The effects of preferred music and its timing on performance, pacing, and psychophysiological responses during the 6-min test}, series = {Journal of human kinetics}, volume = {82}, journal = {Journal of human kinetics}, number = {1}, publisher = {Academy of Physical Education}, address = {Katowice}, issn = {1640-5544}, doi = {10.2478/hukin-2022-0038}, pages = {123 -- 133}, year = {2022}, abstract = {The aim of this study was to investigate the effects of listening to preferred music during a warm up or exercise, on performance during a 6-min all-out exercise test (6-MT) in young adult males. Twenty-five healthy males volunteered to participate in this study. Following a within subject design, participants performed three test conditions (MDT: music during the test; MDW: music during the warm-up; WM: without music) in random order. Outcomes included mean running speed over the 6-min test (MRS6), total distance covered (TDC), heart rate responses (HRpeak, HRmean), blood lactate (3-min after the test), and the rating of perceived exertion (RPE); additionally, feeling scale scores were recorded. Listening to preferred music during running resulted in significant TDC (Delta up arrow 10\%, p=0.006, ES=0.80) and MRS6 (Delta up arrow 14\%, p=0.012, ES=1.02) improvement during the 6-MT, improvement was also noted for the warm-up with music condition (TDC:Delta up arrow 8\%, p=0.028, ES=0.63; MRS6:Delta up arrow 8\%, p=0.032, ES=0.61). A similar reverse "J-shaped" pacing profile was detected during the three conditions. Blood lactate was lower in the MDT condition by 8\% (p=0.01, ES=1.10), but not the MDW condition, compared to MW. In addition, no statistically significant differences were found between the test sessions for the HR, RPE, and feeling scale scores. In conclusion, listening to music during exercise testing would be more beneficial for optimal TDC and MRS6 performances compared to MDW and WM.}, language = {en} } @article{SaidiZouhalBoullosaetal.2022, author = {Saidi, Karim and Zouhal, Hassane and Boullosa, Daniel and Dupont, Gregory and Hackney, Anthony C. and Bideau, Benoit and Granacher, Urs and Ben Abderrahman, Abderraouf}, title = {Biochemical markers and wellness status during a congested match play period in elite soccer players}, series = {International journal of sports physiology and performance : IJSSP}, volume = {17}, journal = {International journal of sports physiology and performance : IJSSP}, number = {4}, publisher = {Human Kinetics Publ.}, address = {Champaign}, issn = {1555-0265}, doi = {10.1123/ijspp.2020-0914}, pages = {605 -- 620}, year = {2022}, abstract = {Objectives: To analyze biochemical markers, wellness status, and physical fitness in elite soccer players in relation to changes in training and match exposure during a congested period of match play. Methods: Fourteen elite soccer players were evaluated 3 times (T1, T2, and T3) over 12 weeks (T1-T2: 6-wk regular period of match play and T2-T3: 6-wk congested period of match play). Players performed vertical jump tests, repeated shuttle sprint ability test, and the Yo-Yo Intermittent Recovery Test at T1, T2, and T3. Plasma C-reactive protein, creatinine, and creatine kinase were analyzed at T1, T2, and T3. Wellness status was measured daily using the Hopper questionnaire (delayed onset of muscle soreness, stress, fatigue, and sleep quality). Training session rating of perceived exertion was also recorded on a daily basis. Results: A significant increase was found in stress, fatigue, delayed onset of muscle soreness scores, and Hopper index during the congested period (between T2 and T3) compared with the regular period (between T1 and T2) (.001 < P < .008, 0.8 < ES < 2.3). Between T2 and T3, significant relationships were found between the percentage variations (Delta\%) of C-reactive protein, and Delta\% of creatine kinase with the Hopper Index, and the Delta\% of fatigue score. In addition, the Delta\% of fatigue score and Delta\% of delayed onset of muscle soreness score correlated with Delta\% Yo-Yo Intermittent Recovery Test and Delta\% best of repeated shuttle sprint ability test (.49 < r < P < .01). Conclusions: An intensive period of congested match play significantly compromised elite soccer players' physical fitness and wellness status. Elite soccer players' wellness status reflects declines in physical fitness during this period while biochemical changes do not.}, language = {en} } @article{HeinzelLorenzBrockhausetal.2014, author = {Heinzel, Stephan and Lorenz, Robert C. and Brockhaus, Wolf-Ruediger and Wuestenberg, Torsten and Kathmann, Norbert and Heinz, Andreas and Rapp, Michael A.}, title = {Working memory load-dependent brain response predicts behavioral training gains in older adults}, series = {The journal of neuroscience}, volume = {34}, journal = {The journal of neuroscience}, number = {4}, publisher = {Society for Neuroscience}, address = {Washington}, issn = {0270-6474}, doi = {10.1523/JNEUROSCI.2463-13.2014}, pages = {1224 -- 1233}, year = {2014}, abstract = {In the domain of working memory (WM), a sigmoid-shaped relationship between WM load and brain activation patterns has been demonstrated in younger adults. It has been suggested that age-related alterations of this pattern are associated with changes in neural efficiency and capacity. At the same time, WM training studies have shown that some older adults are able to increase their WM performance through training. In this study, functional magnetic resonance imaging during an n-back WM task at different WM load levels was applied to compare blood oxygen level-dependent (BOLD) responses between younger and older participants and to predict gains in WM performance after a subsequent 12-session WM training procedure in older adults. We show that increased neural efficiency and capacity, as reflected by more "youth-like" brain response patterns in regions of interest of the frontoparietal WM network, were associated with better behavioral training outcome beyond the effects of age, sex, education, gray matter volume, and baseline WM performance. Furthermore, at low difficulty levels, decreases in BOLD response were found after WM training. Results indicate that both neural efficiency (i. e., decreased activation at comparable performance levels) and capacity (i. e., increasing activation with increasing WM load) of a WM-related network predict plasticity of the WM system, whereas WM training may specifically increase neural efficiency in older adults.}, language = {en} } @article{HeinzelLorenzPelzetal.2016, author = {Heinzel, Stephan and Lorenz, Robert C. and Pelz, Patricia and Heinz, Andreas and Walter, Henrik and Kathmann, Norbert and Rapp, Michael A. and Stelzel, Christine}, title = {Neural correlates of training and transfer effects in working memory in older adults}, series = {NeuroImage : a journal of brain function}, volume = {134}, journal = {NeuroImage : a journal of brain function}, publisher = {Elsevier}, address = {San Diego}, issn = {1053-8119}, doi = {10.1016/j.neuroimage.2016.03.068}, pages = {236 -- 249}, year = {2016}, abstract = {As indicated by previous research, aging is associated with a decline in working memory (WM) functioning, related to alterations in fronto-parietal neural activations. At the same time, previous studies showed that WM training in older adults may improve the performance in the trained task (training effect), and more importantly, also in untrained WM tasks (transfer effects). However, neural correlates of these transfer effects that would improve understanding of its underlying mechanisms, have not been shown in older participants as yet. In this study, we investigated blood-oxygen-level-dependent (BOLD) signal changes during n-back performance and an untrained delayed recognition (Sternberg) task following 12 sessions (45 min each) of adaptive n-back training in older adults. The Sternberg task used in this study allowed to test for neural training effects independent of specific task affordances of the trained task and to separate maintenance from updating processes. Thirty-two healthy older participants (60-75 years) were assigned either to an n-back training or a no-contact control group. Before (t1) and after (t2) training/waiting period, both the n-back task and the Sternberg task were conducted while BOLD signal was measured using functional Magnetic Resonance Imaging (fMRI) in all participants. In addition, neuropsychological tests were performed outside the scanner. WM performance improved with training and behavioral transfer to tests measuring executive functions, processing speed, and fluid intelligence was found. In the training group, BOLD signal in the right lateral middle frontal gyrus/caudal superior frontal sulcus (Brodmann area, BA 6/8) decreased in both the trained n-back and the updating condition of the untrained Sternberg task at t2, compared to the control group. fMRI findings indicate a training-related increase in processing efficiency of WM networks, potentially related to the process of WM updating. Performance gains in untrained tasks suggest that transfer to other cognitive tasks remains possible in aging. (C) 2016 Elsevier Inc. All rights reserved.}, language = {en} } @article{BookerJacobRappetal.2016, author = {Booker, Anke and Jacob, Louis E. C. and Rapp, Michael A. and Bohlken, Jens and Kostev, Karel}, title = {Risk factors for dementia diagnosis in German primary care practices}, series = {International psychogeriatrics}, volume = {28}, journal = {International psychogeriatrics}, publisher = {Cambridge Univ. Press}, address = {New York}, issn = {1041-6102}, doi = {10.1017/S1041610215002082}, pages = {1059 -- 1065}, year = {2016}, abstract = {Background: Dementia is a psychiatric condition the development of which is associated with numerous aspects of life. Our aim was to estimate dementia risk factors in German primary care patients. Methods: The case-control study included primary care patients (70-90 years) with first diagnosis of dementia (all-cause) during the index period (01/2010-12/2014) (Disease Analyzer, Germany), and controls without dementia matched (1:1) to cases on the basis of age, sex, type of health insurance, and physician. Practice visit records were used to verify that there had been 10 years of continuous follow-up prior to the index date. Multivariate logistic regression models were fitted with dementia as a dependent variable and the potential predictors. Conclusions: Risk factors for dementia found in this study are consistent with the literature. Nevertheless, the associations between statin, PPI and antihypertensive drug use, and decreased risk of dementia need further investigations.}, language = {en} } @misc{GarbusowSommerNebeetal.2018, author = {Garbusow, Maria and Sommer, C. and Nebe, S. and Sebold, Miriam and Kuitunen-Paul, S{\"o}ren and Wittchen, H. U. and Smolka, M. and Zimmermann, U. and Rapp, Michael A. and Huys, Q. and Schlagenhauf, Florian and Heinz, A.}, title = {Pavlovian-instrumental transfer in the course of alcohol use disorder}, series = {European psychiatry : the journal of the Association of European Psychiatrists}, volume = {48}, journal = {European psychiatry : the journal of the Association of European Psychiatrists}, publisher = {Elsevier}, address = {ISSY-LES-MOULINEAUX}, issn = {0924-9338}, pages = {S546 -- S546}, year = {2018}, abstract = {Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping on- going thought and behavior. The influence of Pavlovian stimuli on on-going behavior is paradigmatically measured by Pavlovian-to-instrumental-transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent, and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced Pavlovian-Instrumental transfer. Methods: 32 recently detoxified alcohol-dependent patients and 32 age and gender matched healthy controls performed a PIT task with instrumental go/no-go approach behaviours. The task involved both Pavlovian stimuli associated with monetary rewards and losses, and images of drinks. Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs. Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol- dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.}, language = {en} } @article{LorenzGleichBecketal.2014, author = {Lorenz, Robert C. and Gleich, Tobias and Beck, Anne and Poehland, Lydia and Raufelder, Diana and Sommer, Werner and Rapp, Michael A. and Kuehn, Simone and Gallinat, J{\"u}rgen}, title = {Reward anticipation in the adolescent and aging brain}, series = {Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging}, volume = {35}, journal = {Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging}, number = {10}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1065-9471}, doi = {10.1002/hbm.22540}, pages = {5153 -- 5165}, year = {2014}, abstract = {Processing of reward is the basis of adaptive behavior of the human being. Neural correlates of reward processing seem to be influenced by developmental changes from adolescence to late adulthood. The aim of this study is to uncover these neural correlates during a slot machine gambling task across the lifespan. Therefore, we used functional magnetic resonance imaging to investigate 102 volunteers in three different age groups: 34 adolescents, 34 younger adults, and 34 older adults. We focused on the core reward areas ventral striatum (VS) and ventromedial prefrontal cortex (VMPFC), the valence processing associated areas, anterior cingulate cortex (ACC) and insula, as well as information integration associated areas, dorsolateral prefrontal cortex (DLPFC), and inferior parietal lobule (IPL). Results showed that VS and VMPFC were characterized by a hyperactivation in adolescents compared with younger adults. Furthermore, the ACC and insula were characterized by a U-shape pattern (hypoactivation in younger adults compared with adolescents and older adults), whereas the DLPFC and IPL were characterized by a J-shaped form (hyperactivation in older adults compared with younger groups). Furthermore, a functional connectivity analysis revealed an elevated negative functional coupling between the inhibition-related area rIFG and VS in younger adults compared with adolescents. Results indicate that lifespan-related changes during reward anticipation are characterized by different trajectories in different reward network modules and support the hypothesis of an imbalance in maturation of striatal and prefrontal cortex in adolescents. Furthermore, these results suggest compensatory age-specific effects in fronto-parietal regions. Hum Brain Mapp 35:5153-5165, 2014. (c) 2014 Wiley Periodicals, Inc.}, language = {en} } @article{SturmWildermuthStolzetal.2019, author = {Sturm, Heidrun and Wildermuth, Ronja and Stolz, Regina and Bertram, L. and Eschweiler, G. W. and Thomas, C. and Rapp, Michael A. and Joos, S.}, title = {Diverging awareness of postoperative delirium and cognitive dysfunction in German Health Care Providers}, series = {Clinical interventions in agins}, volume = {14}, journal = {Clinical interventions in agins}, publisher = {DOVE Medical Press}, address = {Albany}, issn = {1178-1998}, doi = {10.2147/CIA.S230800}, pages = {2125 -- 2135}, year = {2019}, abstract = {Purpose: Postoperative cognitive dysfunction (POCD) appears in up to 30\% of patients suffering from postoperative delirium (POD). Both are associated with higher mortality and postoperative complications, prolonged hospital stays, and increased costs. Multi-modal models with pre-admission risk reduction counselling, perioperative monitoring, and training of multidisciplinary patient care providers have been shown to decrease the prevalence of both. The aim of our study is to understand how far those measures are known and implemented in routine care and to detect potential gaps in the current practice regarding risk communication and information flow between involved caregivers for patients at risk for POD/POCD. Patients and Methods: As part of a multicenter study, seven semi-structured focus group (FG) discussions with nurses and physicians from tertiary care hospitals (surgery, anesthesiology, and orthopedics, n=31) and general practitioners (GPs) in private practice (n=7) were performed. Transcribed discussions were analyzed using qualitative content analysis. Results: POD is present above all in the daily work of nurses, whereas physicians do not perceive it as a relevant problem. Physicians report that no regular risk assessment or risk communication was performed prior to elective surgery. Information about POD often gets lost during hand-offs and is not regularly reported in discharge letters. Thus, persisting cognitive dysfunction is often missed. The importance of standardized documentation and continuous education concerning risks, screening, and treatment was emphasized. The often-suggested pre-OP medication adjustment was seen as less important; in contrast, avoiding withdrawal was regarded as far more important. Conclusion: Altogether, it seems that standards and available best practice concepts are rarely implemented. In contrast to physicians, nurses are highly aware of delirium and ask for standardized procedures and more responsibility. Therefore, raising awareness regarding risks, screening tools, and effective preventive measures for POD/POCD seems an urgent goal. Nurses should have a central role in coordination and care of POD to prevent the risk for POCD.}, language = {en} } @article{DesernoBeckHuysetal.2015, author = {Deserno, Lorenz and Beck, Anne and Huys, Quentin J. M. and Lorenz, Robert C. and Buchert, Ralph and Buchholz, Hans-Georg and Plotkin, Michail and Kumakara, Yoshitaka and Cumming, Paul and Heinze, Hans-Jochen and Grace, Anthony A. and Rapp, Michael A. and Schlagenhauf, Florian and Heinz, Andreas}, title = {Chronic alcohol intake abolishes the relationship between dopamine synthesis capacity and learning signals in the ventral striatum}, series = {European journal of neuroscience}, volume = {41}, journal = {European journal of neuroscience}, number = {4}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0953-816X}, doi = {10.1111/ejn.12802}, pages = {477 -- 486}, year = {2015}, abstract = {Drugs of abuse elicit dopamine release in the ventral striatum, possibly biasing dopamine-driven reinforcement learning towards drug-related reward at the expense of non-drug-related reward. Indeed, in alcohol-dependent patients, reactivity in dopaminergic target areas is shifted from non-drug-related stimuli towards drug-related stimuli. Such hijacked' dopamine signals may impair flexible learning from non-drug-related rewards, and thus promote craving for the drug of abuse. Here, we used functional magnetic resonance imaging to measure ventral striatal activation by reward prediction errors (RPEs) during a probabilistic reversal learning task in recently detoxified alcohol-dependent patients and healthy controls (N=27). All participants also underwent 6-[F-18]fluoro-DOPA positron emission tomography to assess ventral striatal dopamine synthesis capacity. Neither ventral striatal activation by RPEs nor striatal dopamine synthesis capacity differed between groups. However, ventral striatal coding of RPEs correlated inversely with craving in patients. Furthermore, we found a negative correlation between ventral striatal coding of RPEs and dopamine synthesis capacity in healthy controls, but not in alcohol-dependent patients. Moderator analyses showed that the magnitude of the association between dopamine synthesis capacity and RPE coding depended on the amount of chronic, habitual alcohol intake. Despite the relatively small sample size, a power analysis supports the reported results. Using a multimodal imaging approach, this study suggests that dopaminergic modulation of neural learning signals is disrupted in alcohol dependence in proportion to long-term alcohol intake of patients. Alcohol intake may perpetuate itself by interfering with dopaminergic modulation of neural learning signals in the ventral striatum, thus increasing craving for habitual drug intake.}, language = {en} } @article{HeinzelLorenzQuynhLamDuongetal.2017, author = {Heinzel, Stephan and Lorenz, Robert C. and Quynh-Lam Duong, and Rapp, Michael A. and Deserno, Lorenz}, title = {Prefrontal-parietal effective connectivity during working memory in older adults}, series = {Neurobiology of Aging}, volume = {57}, journal = {Neurobiology of Aging}, publisher = {Elsevier}, address = {New York}, issn = {0197-4580}, doi = {10.1016/j.neurobiolaging.2017.05.005}, pages = {18 -- 27}, year = {2017}, abstract = {Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory (WM)load-dependent manner. However, to date, underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood. The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection. Eighteen healthy younger (age: 20-32 years) and 32 older (60-75 years) participants performed an n-back task with 3 WM load levels during functional magnetic resonance imaging (fMRI). Behavioral and conventional fMRI results replicated age group by WM load interactions. Importantly, the analysis of effective connectivity derived from dynamic causal modeling, indicated an age-and performance-related reduction in WM load-dependent modulation of connectivity from dorsolateral prefrontal cortex to inferior parietal lobule. This finding provides evidence for the proposal that age-related WM decline manifests as deficient WM load-dependent modulation of neuronal top-down control and can integrate implications from theoretical models and previous studies of functional changes in the aging brain.}, language = {en} } @article{SanderKocKwamenetal.2016, author = {Sander, Mathias and Koc, A. and Kwamen, C. T. and Michaels, H. and Reppert, Alexander von and Pudell, Jan-Etienne and Zamponi, Flavio and Bargheer, Matias and Sellmann, J. and Schwarzkopf, J. and Gaal, P.}, title = {Characterization of an ultrafast Bragg-Switch for shortening hard x-ray pulses}, series = {Journal of applied physics}, volume = {120}, journal = {Journal of applied physics}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0021-8979}, doi = {10.1063/1.4967835}, pages = {7}, year = {2016}, abstract = {We present a nanostructured device that functions as photoacoustic hard x-ray switch. The device is triggered by femtosecond laser pulses and allows for temporal gating of hard x-rays on picosecond (ps) timescales. It may be used for pulse picking or even pulse shortening in 3rd generation synchrotron sources. Previous approaches mainly suffered from insufficient switching contrasts due to excitation-induced thermal distortions. We present a new approach where thermal distortions are spatially separated from the functional switching layers in the structure. Our measurements yield a switching contrast of 14, which is sufficient for efficient hard x-ray pulse shortening. The optimized structure also allows for utilizing the switch at high repetition rates of up to 208 kHz. Published by AIP Publishing.}, language = {en} } @misc{GorskiJungLietal.2020, author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.}, title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t}, number = {19}, doi = {10.25932/publishup-56537}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565379}, pages = {14}, year = {2020}, abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.}, language = {en} } @article{RothwellMurphyAleksandrovaetal.2020, author = {Rothwell, Joseph A. and Murphy, Neil and Aleksandrova, Krasimira and Schulze, Matthias Bernd and Bešević, Jelena and Kliemann, Nathalie and Jenab, Mazda and Ferrari, Pietro and Achaintre, David and Gicquiau, Audrey and Vozar, B{\´e}atrice and Scalbert, Augustin and Huybrechts, Inge and Freisling, Heinz and Prehn, Cornelia and Adamski, Jerzy and Cross, Amanda J. and Pala, Valeria Maria and Boutron-Ruault, Marie-Christine and Dahm, Christina C. and Overvad, Kim and Gram, Inger Torhild and Sandanger, Torkjel M. and Skeie, Guri and Jakszyn, Paula and Tsilidis, Kostas K. and Hughes, David J. and van Guelpen, Bethany and Bod{\´e}n, Stina and S{\´a}nchez, Maria-Jos{\´e} and Schmidt, Julie A. and Katzke, Verena and K{\"u}hn, Tilman and Colorado-Yohar, Sandra and Tumino, Rosario and Bueno-de-Mesquita, Bas and Vineis, Paolo and Masala, Giovanna and Panico, Salvatore and Eriksen, Anne Kirstine and Tj{\o}nneland, Anne and Aune, Dagfinn and Weiderpass, Elisabete and Severi, Gianluca and Chaj{\`e}s, V{\´e}ronique and Gunter, Marc J.}, title = {Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort}, series = {Clinical gastroenterology and hepatology}, volume = {20}, journal = {Clinical gastroenterology and hepatology}, publisher = {Elsevier}, address = {New York, NY}, issn = {1542-3565}, doi = {10.1016/j.cgh.2020.11.045}, pages = {E1061 -- E1082}, year = {2020}, abstract = {BACKGROUND \& AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95\% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95\% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95\% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95\% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.}, language = {en} }