@article{WicaksonoBraunBernhardtetal.2022,
  author    = {Wicaksono, Wisnu Adi and Braun, Maria and Bernhardt, J{\"o}rg and Riedel, Katharina and Cernava, Tomislav and Berg, Gabriele},
  title     = {Trade-off for survival},
  series = {Environment international : a journal of science, technology, health, monitoring and policy},
  volume    = {168},
  journal   = {Environment international : a journal of science, technology, health, monitoring and policy},
  publisher = {Elsevier Science},
  address   = {Amsterdam [u.a.]},
  issn      = {1873-6750},
  doi       = {10.1016/j.envint.2022.107474},
  pages     = {13},
  year      = {2022},
  abstract  = {The environmental micmbiota is increasingly exposed to chemical pollution. While the emergence of multi-resistant pathogens is recognized as a global challenge, our understanding of antimicrobial resistance (AMR) development from native microbiomes and the risks associated with chemical exposure is limited. By implementing a lichen as a bioindicator organism and model for a native microbiome, we systematically examined responses towards antimicrobials (colistin, tetracycline, glyphosate, and alkylpyrazine). Despite an unexpectedly high resilience, we identified potential evolutionary consequences of chemical exposure in terms of composition and functioning of native bacterial communities. Major shifts in bacterial composition were observed due to replacement of naturally abundant taxa; e.g. Chthoniobacterales by Pseudomonadales. A general response, which comprised activation of intrinsic resistance and parallel reduction of metabolic activity at RNA and protein levels was deciphered by a multi-omics approach. Targeted analyses of key taxa based on metagenome-assembled genomes reflected these responses but also revealed diversified strategies of their players. Chemical-specific responses were also observed, e.g., glyphosate enriched bacterial r-strategists and activated distinct ARGs. Our work demonstrates that the high resilience of the native micmbiota toward antimicrobial exposure is not only explained by the presence of antibiotic resistance genes but also adapted metabolic activity as a trade-off for survival. Moreover, our results highlight the importance of native microbiomes as important but so far neglected AMR reservoirs. We expect that this phenomenon is representative for a wide range of environmental microbiota exposed to chemicals that potentially contribute to the emergence of antibiotic-resistant bacteria from natural environments.},
  language  = {en}
}
@article{PinkernelleAbrahamSeideletal.2009,
  author    = {Pinkernelle, Josephine and Abraham, Andreas and Seidel, Katja and Braun, Katharina},
  title     = {Paternal deprivation induces dendritic and synaptic changes and hemispheric asymmetry of pyramidal neurons in the somatosensory cortex},
  issn      = {1932-8451},
  doi       = {10.1002/Dneu.20726},
  year      = {2009},
  abstract  = {Similar to maternal care, paternal care is a source of neonatal sensory stimulation, which in primates and rodents has been shown to be essential for developing structure and function of sensory cortices. The aim of our study in the biparental rodent Octodon degus was to assess the impact of paternal deprivation on dendritic and synaptic development in the somatosensory cortex. We (i) quantified the amount of paternal care in relation to total parental investment and (ii) compared dendritic and synaptic development of pyramidal neurons in the somatosensory cortex of animals raised by a single mother or by both parents. On the behavioral level we show that paternal care comprises 37\% of total parent-offspring interactions, and that the somatosensory stimulation provided by the fathers primarily consists of huddling, licking/grooming, and playing. On the morphological level we found that, compared with offspring raised by both parents (mother and father), the father-deprived animals displayed significantly reduced spine numbers on the basal dendrites of pyramidal neurons. Furthermore, paternal deprivation induces hemispheric asymmetry of the dendritic morphology of somatosensory pyramidal neurons. Father-deprived animals show shorter and less complex basal dendrites in the left somatosensory cortex compared with the right hemisphere. These findings indicate that paternal deprivation results in delayed or retarded dendritic and synaptic development of somatosensory circuits.},
  language  = {en}
}
@article{WirthHatterDrostetal.2015,
  author    = {Wirth, Jonas and Hatter, Nino and Drost, Robert and Umbach, Tobias R. and Barja, Sara and Zastrow, Matthias and R{\"u}ck-Braun, Karola and Pascual, Jose Ignacio and Saalfrank, Peter and Franke, Katharina J.},
  title     = {Diarylethene Molecules on a Ag(111) Surface: Stability and Electron-Induced Switching},
  series = {The journal of physical chemistry : C, Nanomaterials and interfaces},
  volume    = {119},
  journal   = {The journal of physical chemistry : C, Nanomaterials and interfaces},
  number    = {9},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1932-7447},
  doi       = {10.1021/jp5122036},
  pages     = {4874 -- 4883},
  year      = {2015},
  abstract  = {Diarylethene derivatives are photochromic molecular switches, undergoing a ring-opening/-closing reaction by illumination with light. The symmetry of the closed form is determined by the WoodWard Hoffinann rules according to which the reaction proceeds by corirotatory rotation -in that case. Here, we show by a cOrnbined approach of scanning tunneling microscopy (STM) and density functional theory (DFT) calculations that the Open isomer of 4,4'-(4,4'-(perfluorocydopent-1-ene-1,2-diyl)bis(5-methyl-thiophent-4,2,4-dipyridine) (PDTE) retains its open form upon adsorption on a Ag(111) surface. It caribe switched into a closed form, which we identify as the digrotatOly cydization product, by controlled manipulation 'With the STM tip, Evidence of an electric-field dependent switching-process 'is interpreted on the basis of a Simple electroStatic Model, which suggests that the reaction proceedS via an "upright" intermediate state. This pathway thus strongly differs from the switching reaction in solution.},
  language  = {en}
}
@article{HeinrichEhlertHatteretal.2018,
  author    = {Heinrich, Benjamin W. and Ehlert, Christopher and Hatter, Nino and Braun, Lukas and Lotze, Christian and Saalfrank, Peter and Franke, Katharina J.},
  title     = {Control of oxidation and spin state in a single-molecule junction},
  series = {ACS nano},
  volume    = {12},
  journal   = {ACS nano},
  number    = {4},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1936-0851},
  doi       = {10.1021/acsnano.8b00312},
  pages     = {3172 -- 3177},
  year      = {2018},
  abstract  = {The oxidation and spin state of a metal-organic molecule determine its chemical reactivity and magnetic properties. Here, we demonstrate the reversible control of the oxidation and spin state in a single Fe porphyrin molecule in the force field of the tip of a scanning electron tunneling microscope. Within the regimes of half-integer and integer spin state, we can further track the evolution of the magnetocrystalline anisotropy. Our experimental results are corroborated by density functional theory and wave function theory. This combined analysis allows us to draw a complete picture of the molecular states over a large range of intramolecular deformations.},
  language  = {en}
}