@article{DiekmannAndresBeckeretal.2019, author = {Diekmann, Martin and Andres, Christian and Becker, Thomas and Bennie, Jonathan and Blueml, Volker and Bullock, James M. and Culmsee, Heike and Fanigliulo, Miriam and Hahn, Annett and Heinken, Thilo and Leuschner, Christoph and Luka, Stefanie and Meissner, Justus and M{\"u}ller, Josef and Newton, Adrian and Peppler-Lisbach, Cord and Rosenthal, Gert and van den Berg, Leon J. L. and Vergeer, Philippine and Wesche, Karsten}, title = {Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe}, series = {Journal of vegetation science}, volume = {30}, journal = {Journal of vegetation science}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {1100-9233}, doi = {10.1111/jvs.12727}, pages = {187 -- 202}, year = {2019}, abstract = {Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species.}, language = {en} } @article{StoesselSchultedosSantosetal.2018, author = {Stoessel, Daniel and Schulte, Claudia and dos Santos, Marcia C. Teixeira and Scheller, Dieter and Rebollo-Mesa, Irene and Deuschle, Christian and Walther, Dirk and Schauer, Nicolas and Berg, Daniela and da Costa, Andre Nogueira and Maetzler, Walter}, title = {Promising Metabolite Profiles in the Plasma and CSF of Early Clinical}, series = {Frontiers in Aging Neuroscience}, volume = {10}, journal = {Frontiers in Aging Neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1663-4365}, doi = {10.3389/fnagi.2018.00051}, pages = {14}, year = {2018}, abstract = {Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF). Here, we applied untargeted high-resolution mass spectrometry to determine plasma and CSF metabolite profiles. We semiquantitatively determined small-molecule levels (<= 1.5 kDa) in the plasma and CSF from early PD patients (disease duration 0-4 years; n = 80 and 40, respectively), and sex-and age-matched controls (n = 76 and 38, respectively). We performed statistical analyses utilizing partial least square and random forest analysis with a 70/30 training and testing split approach, leading to the identification of 20 promising plasma and 14 CSF metabolites. The semetabolites differentiated the test set with an AUC of 0.8 (plasma) and 0.9 (CSF). Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipid, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches. Further studies will enable to develop a potential metabolite-based biomarker panel specific for PD}, language = {en} } @inproceedings{HeinischRomeikeKnobelsdorfetal.2013, author = {Heinisch, Isabelle and Romeike, Ralf and Knobelsdorf, Maria and Kreitz, Christoph and Nyl{\´e}n, Aletta and D{\"o}rge, Christina and G{\"o}ttel, Timo and Holz, Jan and Bergner, Nadine and Schroeder, Ulrik and Metzger, Christiane and Haag, Johann and Abke, J{\"o}rg and Schwirtlich, Vincent and Sedelmaier, Yvonne and M{\"u}ller, Dorothee and Frommer, Andreas and Humbert, Ludger and Berges, Marc and M{\"u}hling, Andreas and Hubwieser, Peter and Steuer, Horst and Engbring, Dieter and Selke, Harald and Drews, Paul and Schirmer, Ingrid and Morisse, Marcel and Sagawe, Arno and Rolf, Arno and Friedemann, Stefan and Gr{\"o}ger, Stefan and Schumann, Matthias and Klinger, Melanie and Polutina, Olena and Bibel, Ariane and G{\"o}tz, Christian and Brinda, Torsten and Apel, Rebecca and Berg, Tobias and Bergner, Nadine and Chatti, Mohamed Amine and Leicht-Scholten, Carmen and Schroeder, Ulrik and Al-Saffar, Loay Talib and Petre, Marian and Schirmer, Ingrid and Rick, Detlef}, title = {HDI 2012 - Informatik f{\"u}r eine nachhaltige Zukunft : 5. Fachtagung Hochschuldidaktik der Informatik ; 06.-07. November 2012, Universit{\"a}t Hamburg}, editor = {Forbrig, Peter and Rick, Detlef and Schmolitzky, Axel}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-220-9}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62891}, pages = {169}, year = {2013}, abstract = {Die Tagungsreihe zur Hochschuldidaktik der Informatik HDI wird vom Fachbereich Informatik und Ausbildung / Didaktik der Informatik (IAD) in der Gesellschaft f{\"u}r Informatik e. V. (GI) organisiert. Sie dient den Lehrenden der Informatik in Studieng{\"a}ngen an Hochschulen als Forum der Information und des Austauschs {\"u}ber neue didaktische Ans{\"a}tze und bildungspolitische Themen im Bereich der Hochschulausbildung aus der fachlichen Perspektive der Informatik. Diese f{\"u}nfte HDI 2012 wurde an der Universit{\"a}t Hamburg organisiert. F{\"u}r sie wurde das spezielle Motto „Informatik f{\"u}r eine nachhaltige Zukunft" gew{\"a}hlt, um insbesondere Fragen der Bildungsrelevanz informatischer Inhalte, der Kompetenzen f{\"u}r Studierende informatisch gepr{\"a}gter Studieng{\"a}nge und der Rolle der Informatik in der Hochschulentwicklung zu diskutieren.}, language = {de} } @article{StoesselStellmannWillingetal.2018, author = {Stoessel, Daniel and Stellmann, Jan-Patrick and Willing, Anne and Behrens, Birte and Rosenkranz, Sina C. and Hodecker, Sibylle C. and Stuerner, Klarissa H. and Reinhardt, Stefanie and Fleischer, Sabine and Deuschle, Christian and Maetzler, Walter and Berg, Daniela and Heesen, Christoph and Walther, Dirk and Schauer, Nicolas and Friese, Manuel A. and Pless, Ole}, title = {Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring}, series = {Frontiers in human neuroscienc}, volume = {12}, journal = {Frontiers in human neuroscienc}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2018.00226}, pages = {13}, year = {2018}, abstract = {Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing remitting subtype (RRMS), primary neurodegenerative disease (Parkinson's disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies.}, language = {en} } @article{BergBilzRistowetal.2008, author = {Berg, Christian and Bilz, Melanie and Ristow, Michael and Raab, Bernd}, title = {Important Plant Areas (IPA) : ein internationales Konzept zum Schutz der Wildpflanzen der Erde}, year = {2008}, language = {de} } @article{KernHellebrandGoemmeletal.2012, author = {Kern, J{\"u}rgen and Hellebrand, Hans J{\"u}rgen and G{\"o}mmel, Michael and Ammon, Christian and Berg, Werner}, title = {Effects of climatic factors and soil management on the methane flux in soils from annual and perennial energy crops}, series = {Biology and fertility of soils}, volume = {48}, journal = {Biology and fertility of soils}, number = {1}, publisher = {Springer}, address = {New York}, issn = {0178-2762}, doi = {10.1007/s00374-011-0603-z}, pages = {1 -- 8}, year = {2012}, abstract = {Methane flux rates were measured on a loamy sand soil within perennial and annual energy crops in northeast Germany. The study was performed in closed chambers between 2003 and 2005 with four measurements per week. A mixed linear model including the fixed effects of year, rotation period, crop and fertilisation was applied to determine the influence of climatic factors and soil management on the CH4 flux. Soil water content and air temperature were added as co-variables. With the exception of air temperature, all fixed effects and the co-variable soil water content influenced the CH4 flux. The soil of annual crops consumed 6.1 mu g CH4 m(-2) h(-1), significantly more than the soil of perennial crops with 4.3 mu g CH4 m(-2) h(-1). It is suggested that soil water content plays the key role in CH4 flux between pedosphere and atmosphere. In the range of water contents between 5\% and 15\%, our model describes that a soil water content increase of 1\% induces a net emission of 0.375 mu g CH4 m(-2) h(-1). As the soil of the experimental field was well-drained and aerobic, it represented a net sink for CH4 throughout the study period.}, language = {en} } @misc{StoesselStellmannWillingetal.2018, author = {Stoessel, Daniel and Stellmann, Jan-Patrick and Willing, Anne and Behrens, Birte and Rosenkranz, Sina C. and Hodecker, Sibylle C. and St{\"u}rner, Klarissa H. and Reinhardt, Stefanie and Fleischer, Sabine and Deuschle, Christian and Maetzler, Walter and Berg, Daniela and Heesen, Christoph and Walther, Dirk and Schauer, Nicolas and Friese, Manuel A. and Pless, Ole}, title = {Metabolomic profiles for primary progressive multiple sclerosis stratification and disease course monitoring}, series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe}, number = {694}, issn = {1866-8372}, doi = {10.25932/publishup-42630}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-426307}, pages = {13}, year = {2018}, abstract = {Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing remitting subtype (RRMS), primary neurodegenerative disease (Parkinson's disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies.}, language = {en} } @book{WiemannEmigSchmittKilbetal.2010, author = {Wiemann, Dirk and Emig, Rainer and Schmitt-Kilb, Christian and Stedman, Gesa and Berg, Sebastian}, title = {Journal for the Study of British Cultures}, publisher = {K{\"o}nigshausen \& Neumann GmbH}, address = {W{\"u}rzburg}, issn = {0944-9094}, pages = {0944-9094}, year = {2010}, language = {en} } @article{HavingaKoolAchilleetal.2016, author = {Havinga, Reinout and Kool, Anneleen and Achille, Frederic and Bavcon, Joze and Berg, Christian and Bonomi, Costantino and Burkart, Michael and De Meyere, Dirk and Havstrom, Mats and Kessler, Paul and Knickmann, Barbara and Koester, Nils and Martinez, Remy and Ostgaard, Havard and Ravnjak, Blanka and Scheen, Anne-Cathrine and Smith, Pamela and Smith, Paul and Socher, Stephanie A. and Vange, Vibekke}, title = {The Index Seminum: Seeds of change for seed exchange}, series = {Taxon}, volume = {65}, journal = {Taxon}, publisher = {International Association for Plant Taxonomy}, address = {Bratislava}, issn = {0040-0262}, doi = {10.12705/652.9}, pages = {333 -- 336}, year = {2016}, abstract = {Botanic gardens have been exchanging seeds through seed catalogues for centuries. In many gardens, these catalogues remain an important source of plant material. Living collections have become more relevant for genetic analysis and derived research, since genomics of non-model organisms heavily rely on living material. The range of species that is made available annually on all seed lists combined, provides an unsurpassed source of instantly accessible plant material for research collections. Still, the Index Seminum has received criticism in the past few decades. The current exchange model dictates that associated data is manually entered into each database. The amount of time involved and the human errors occurring in this process are difficult to justify when the data was initially produced as a report from another database. The authors propose that an online marketplace for seed exchange should be established, with enhanced search possibilities and downloadable accession data in a standardised format. Such online service should preferably be supervised and coordinated by Botanic Gardens Conservation International (BGCI). This manuscript is the outcome of a workshop on July 9th, 2015, at the European botanic gardens congress "Eurogard VII" in Paris, where the first two authors invited members of the botanic garden community to discuss how the anachronistic Index Seminum can be transformed into an improved and modern tool for seed exchange.}, language = {en} } @article{NendelRecklingDebaekeetal.2023, author = {Nendel, Claas and Reckling, Moritz and Debaeke, Philippe and Schulz, Susanne and Berg-Mohnicke, Michael and Constantin, Julie and Fronzek, Stefan and Hoffmann, Munir and Jakšić, Snežana and Kersebaum, Kurt-Christian and Klimek-Kopyra, Agnieszka and Raynal, H{\´e}l{\`e}ne and Schoving, C{\´e}line and Stella, Tommaso and Battisti, Rafael}, title = {Future area expansion outweighs increasing drought risk for soybean in Europe}, series = {Global change biology}, volume = {29}, journal = {Global change biology}, number = {5}, publisher = {Wiley-Blackwell}, address = {Ocford [u.a]}, issn = {1354-1013}, doi = {10.1111/gcb.16562}, pages = {1340 -- 1358}, year = {2023}, abstract = {The European Union is highly dependent on soybean imports from overseas to meet its protein demands. Individual Member States have been quick to declare self-sufficiency targets for plant-based proteins, but detailed strategies are still lacking. Rising global temperatures have painted an image of a bright future for soybean production in Europe, but emerging climatic risks such as drought have so far not been included in any of those outlooks. Here, we present simulations of future soybean production and the most prominent risk factors across Europe using an ensemble of climate and soybean growth models. Projections suggest a substantial increase in potential soybean production area and productivity in Central Europe, while southern European production would become increasingly dependent on supplementary irrigation. Average productivity would rise by 8.3\% (RCP 4.5) to 8.7\% (RCP 8.5) as a result of improved growing conditions (plant physiology benefiting from rising temperature and CO2 levels) and farmers adapting to them by using cultivars with longer phenological cycles. Suitable production area would rise by 31.4\% (RCP 4.5) to 37.7\% (RCP 8.5) by the mid-century, contributing considerably more than productivity increase to the production potential for closing the protein gap in Europe. While wet conditions at harvest and incidental cold spells are the current key challenges for extending soybean production, the models and climate data analysis anticipate that drought and heat will become the dominant limitations in the future. Breeding for heat-tolerant and water-efficient genotypes is needed to further improve soybean adaptation to changing climatic conditions.}, language = {en} }