@misc{FischerRaederWewetzeretal.2004, author = {Fischer, Florian and R{\"a}der, Andy and Wewetzer, Gudrun and Hempel, Luisa and Sack, Beate and Schwill, Andreas and Surrey, Heike and Claussen, Martin and Klein, Oliver and Czempinski, Katrin and K{\"u}chmeister, Heike and Gonz{\´a}lez, Antonio Mart{\´i}nez and Pecher, Klaus and Resch-Esser, Ursula and Gommert, Natalie}, title = {Portal = Unbekanntes Terrain: Die EU-Erweiterung birgt neue M{\"o}glichkeiten}, number = {06-08/2004}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-43980}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-439806}, pages = {51}, year = {2004}, abstract = {Aus dem Inhalt: - Unbekanntes Terrain: Die EU-Erweiterung birgt neue M{\"o}glichkeiten - Zehn Jahre MenschenRechtsZentrum - Wassermangel im Nahen Osten - Karl-Scheel-Preis f{\"u}r Turbulenzforschung}, language = {de} } @article{BraigKriegsVoigtlaenderetal.2017, author = {Braig, Friederike and Kriegs, Malte and Voigtlaender, Minna and Habel, Beate and Grob, Tobias and Biskup, Karina and Blanchard, Veronique and Sack, Markus and Thalhammer, Anja and Ben Batalla, Isabel and Braren, Ingke and Laban, Simon and Danielczyk, Antje and Goletz, Steffen and Jakubowicz, Elzbieta and Maerkl, Bruno and Trepel, Martin and Knecht, Rainald and Riecken, Kristoffer and Fehse, Boris and Loges, Sonja and Bokemeyer, Carsten and Binder, Mascha}, title = {Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K-521 Polymorphism}, series = {Cancer research}, volume = {77}, journal = {Cancer research}, number = {5}, publisher = {American Association for Cancer Research}, address = {Philadelphia}, issn = {0008-5472}, doi = {10.1158/0008-5472.CAN-16-0754}, pages = {1188 -- 1199}, year = {2017}, abstract = {Head and neck squamous cell carcinomas (HNSCC) exhibiting resistance to the EGFR-targeting drug cetuximab poses a challenge to their effective clinical management. Here, we report a specific mechanism of resistance in this setting based upon the presence of a single nucleotide polymorphism encoding EGFR-K-521 (K-allele), which is expressed in > 40\% of HNSCC cases. Patients expressing the K-allele showed significantly shorter progressionfree survival upon palliative treatment with cetuximab plus chemotherapy or radiation. In several EGFR-mediated cancer models, cetuximab failed to inhibit downstream signaling or to kill cells harboring a high K-allele frequency. Cetuximab affinity for EGFR-K-521 was reduced slightly, but ligand-mediated EGFR acti-vation was intact. We found a lack of glycan sialyation on EGFR-K-521 that associated with reduced protein stability, suggesting a structural basis for reduced cetuximab efficacy. CetuGEX, an antibody with optimized Fc glycosylation targeting the same epitope as cetuximab, restored HNSCC sensitivity in a manner associated with antibody-dependent cellular cytotoxicity rather than EGFR pathway inhibition. Overall, our results highlight EGFR-K-521 expression as a key mechanism of cetuximab resistance to evaluate prospectively as a predictive biomarker in HNSCC patients. Further, they offer a preclinical rationale for the use of ADCC-optimized antibodies to treat tumors harboring this EGFR isoform.}, language = {en} } @article{PollatosDietelHerbertetal.2011, author = {Pollatos, Olga and Dietel, Anja and Herbert, Beate M. and Wankner, Sarah and Wachsmuth, Cornelia and Henningsen, Peter and Sack, Martin}, title = {Blunted autonomic reactivity and increased pain tolerance in somatoform patients}, series = {Pain : journal of the International Association for the Study of Pain}, volume = {152}, journal = {Pain : journal of the International Association for the Study of Pain}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-3959}, doi = {10.1016/j.pain.2011.05.024}, pages = {2157 -- 2164}, year = {2011}, abstract = {Somatoform disorders are characterized by the presence of multiple somatic symptoms. Patients often experience different pain syndromes, and recent research suggests that sympathovagal balance is disturbed in somatoform patients, which could be related to alteration in pain sensitivity. This study analyzed how proposed sympathovagal imbalance interacts with objective pain assessment and the imagination of pain in somatoform disorders. Twenty-one patients (4 men) with diagnosed multisomatoform disorder were included in the study and matched to healthy control subjects. Autonomic measures and heart rate variability were assessed during baseline; pain perception was assessed by means of a pressure algometer and pain imagination. We found evidence for a sympathovagal imbalance in somatoform disorders characterized by low parasympathetic activation and high sympathetic activation during all conditions. Additionally, somatoform patients had reduced pain tolerance. Vagal withdrawal during pain assessment was more pronounced for healthy control subjects and correlated positively with assessed pain tolerance. During imagination somatoform, patients reported higher pain unpleasantness and higher pain intensity as compared to control subjects. We conclude that our data demonstrate an imbalance in sympathovagal activation and a hyposensitivity to pain tolerance stimuli in somatoform disorders. Parasympathetic reactivity might form crucial information when judging pain-associated affective-motivational components. Our results might be attributable to a deficient detection of visceral signals and might be a pathogenetic mechanism for the development of emotional difficulties and increased everyday vulnerability in somatoform patients.}, language = {en} } @article{PollatosHerbertWankneretal.2011, author = {Pollatos, Olga and Herbert, Beate M. and Wankner, Sarah and Dietel, Anja and Wachsmuth, Cornelia and Henningsen, Peter and Sack, Martin}, title = {Autonomic imbalance is associated with reduced facial recognition in somatoform disorders}, series = {Journal of psychosomatic research}, volume = {71}, journal = {Journal of psychosomatic research}, number = {4}, publisher = {Elsevier}, address = {Oxford}, issn = {0022-3999}, doi = {10.1016/j.jpsychores.2011.03.012}, pages = {232 -- 239}, year = {2011}, abstract = {Objectives: Somatoform disorders are characterized by the presence of multiple somatic symptoms. While the accuracy of perceiving bodily signal (interoceptive awareness) is only sparely investigated in somatoform disorders, recent research has associated autonomic imbalance with cognitive and emotional difficulties in stress-related diseases. This study aimed to investigate how sympathovagal reactivity interacts with performance in recognizing emotions in faces (facial recognition task). Methods: Using a facial recognition and appraisal task, skin conductance levels (SCLs), heart rate (HR) and heart rate variability (HRV) were assessed in 26 somatoform patients and compared to healthy controls. Interoceptive awareness was assessed by a heartbeat detection task. Results: We found evidence for a sympathovagal imbalance in somatoform disorders characterized by low parasympathetic reactivity during emotional tasks and increased sympathetic activation during baseline. Somatoform patients exhibited a reduced recognition performance for neutral and sad emotional expressions only. Possible confounding variables such as alexithymia, anxiety or depression were taken into account. Interoceptive awareness was reduced in somatoform patients. Conclusions: Our data demonstrate an imbalance in sympathovagal activation in somatoform disorders associated with decreased parasympathetic activation. This might account for difficulties in processing of sad and neutral facial expressions in somatoform patients which might be a pathogenic mechanism for increased everyday vulnerability.}, language = {en} }