@article{AbdallaAbramowskiAharonianetal.2016, author = {Abdalla, Hassan E. and Abramowski, Attila and Aharonian, Felix A. and Benkhali, Fai{\c{c}}al Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Arrieta, M. and Aubert, Pierre and Backes, Michael and Balzer, Arnim and Barnard, Michelle and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, K. and Birsin, E. and Blackwell, R. and Bottcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Capasso, M. and Carr, John and Casanova, Sabrina and Chakraborty, N. and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chen, Andrew and Chevalier, J. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Condon, B. and Conrad, Jan and Couturier, C. and Cui, Y. and Davids, I. D. and Degrange, B. and Deil, Christoph and deWilt, P. and Djannati-Atai, Arache and Domainko, Wilfried and Donath, Axel and Dubus, Guillaume and Dutson, Kate and Dyks, J. and Dyrda, M. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, Stuart and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Foerster, A. and Funk, S. and F{\"u}ßling, Matthias and Gabici, Stefano and Gajdus, M. and Gallant, Y. A. and Garrigoux, T. and Giavitto, Gianluca and Giebels, B. and Glicenstein, J. F. and Gottschall, Daniel and Goyal, A. and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Hahn, J. and Hawkes, J. and Heinzelmann, G. and Henri, Gilles and Hermann, G. and Hervet, Olivier and Hillert, A. and Hinton, James Anthony and Hofmann, Werner and Hoischen, Clemens and Holler, M. and Horns, D. and Ivascenko, Alex and Jacholkowska, A. and Jamrozy, Marek and Janiak, M. and Jankowsky, D. and Jankowsky, Felix and Jingo, M. and Jogler, Tobias and Jouvin, Lea and Jung-Richardt, Ira and Kastendieck, M. A. and Katarzynski, Krzysztof and Katz, Uli and Kerszberg, D. and Khelifi, B. and Kieffer, M. and King, J. and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, Michael and Krayzel, F. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, Jeanie and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, Thomas and Lorentz, M. and Lui, R. and Lypova, Iryna and Marandon, Vincent and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, Michael and Meintjes, Petrus Johannes and Menzler, U. and Meyer, Manuel and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, T. and de Naurois, Mathieu and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, Hirokazu and Ohm, Stefan and Oettl, S. and Ostrowski, M. and Oya, I. and Padovani, Marco and Panter, M. and Parsons, R. D. and Arribas, M. Paz and Pekeur, N. W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and Prokhorov, Dmitry and Prokoph, Heike and Puehlhofer, Gerd and Punch, Michael and Quirrenbach, Andreas and Raab, S. and Reimer, Anita and Reimer, Olaf and Renaud, M. and de los Reyes, R. and Rieger, Frank and Romoli, Carlo and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Salek, David and Sanchez, David A. and Santangelo, Andrea and Sasaki, Manami and Schlickeiser, Reinhard and Schussler, F. and Schulz, Andreas and Schwanke, U. and Schwemmer, S. and Seyffert, A. S. and Shafi, N. and Simoni, R. and Sol, H. and Spanier, Felix and Spengler, G. and Spiess, F. and Stawarz, Lukasz and Steenkamp, R. and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Tuffs, R. and van der Walt, Johan and van Eldik, Christopher and van Soelen, Brian and Vasileiadis, Georges and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, Jacco and Voisin, F. and Voelk, Heinrich J. and Vuillaume, Thomas and Wadiasingh, Z. and Wagner, Stefan J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, Alicja and Willmann, P. and Woernlein, A. and Wouters, Denis and Yang, R. and Zabalza, Victor and Zaborov, D. and Zacharias, M. and Zdziarski, A. A. and Zech, Andreas and Zefi, F. and Ziegler, A. and Zywucka, Natalia}, title = {Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS}, series = {Physical review letters}, volume = {117}, journal = {Physical review letters}, publisher = {American Physical Society}, address = {College Park}, organization = {HESS Collaboration}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.117.111301}, pages = {6}, year = {2016}, abstract = {The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section . These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe values expected from the thermal relic density for TeV DM particles.}, language = {en} } @misc{AbramowskiAharonianBenkhalietal.2015, author = {Abramowski, Attila and Aharonian, Felix A. and Benkhali, Faical Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Backes, Michael and Balenderan, Shangkari and Balzer, Arnim and Barnacka, Anna and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, Konrad and Birsin, E. and Biteau, Jonathan and B{\"o}ttcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Carrigan, Svenja and Casanova, Sabrina and Chadwick, Paula M. and Chakraborty, Nachiketa and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Conrad, Jan and Couturier, Claire and Cui, Yudong and Davids, Isak Delberth and Degrange, Bernhard and Deil, Christoph and deWilt, P. and Djannati-Ata{\"i}, A. and Domainko, Wilfried and Donath, Axel and Dubus, G. and Dutson, K. and Dyks, J. and Dyrda, M. and Edwards, Tanya and Egberts, Kathrin and Eger, Peter and Espigat, P. and Farnier, C. and Fegan, Stephen and Feinstein, Fabrice and Fernandes, Milton Virgilio and Fernandez, Diane and Fiasson, A. and Fontaine, Gerard and F{\"o}rster, Andreas and Fuessling, M. and Gabici, S. and Gajdus, M. and Gallant, Yves A. and Garrigoux, Tania and Giavitto, G. and Giebels, Berrie and Glicenstein, Jean-Francois and Gottschall, Daniel and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Haeffner, S. and Hahn, Joachim and Harris, Jonathan and Heinzelmann, G{\"o}tz and Henri, G. and Hermann, German and Hervet, O. and Hillert, Andreas and Hinton, James Anthony and Hofmann, Werner and Hofverberg, Petter and Holler, Markus and Horns, Dieter and Ivascenko, Alex and Jacholkowska, A. and Jahn, C. and Jamrozy, Marek and Janiak, M. and Jankowsky, F. and Jung-Richardt, I. and Kastendieck, Max Anton and Katarzynski, K. and Katz, U. and Kaufmann, S. and Khelifi, B. and Kieffer, Michel and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, David and Komin, Nu and Kosack, Karl and Krakau, Steffen and Krayzel, F. and Krueger, Pat P. and Laffon, H. and Lamanna, G. and Lefaucheur, J. and Lefranc, Valentin and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Lohse, Thomas and Lopatin, A. and Lu, Chia-Chun and Marandon, Vincent and Marcowith, Alexandre and Marx, Ramin and Maurin, G. and Maxted, Nigel and Mayer, Michael and McComb, T. J. Lowry and Mehault, J. and Meintjes, P. J. and Menzler, Ulf and Meyer, M. and Mitchell, Alison M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, Thomas and de Naurois, Mathieu and Niemiec, J. and Nolan, Sam J. and Oakes, Louise and Odaka, Hirokazu and Ohm, S. and Optiz, Bj{\"o}rn and Ostrowski, Michal and Oya, I. and Panter, Michael and Parsons, R. Daniel and Arribas, M. Paz and Pekeur, Nikki W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and P{\"u}hlhofer, Gerd and Punch, M. and Quirrenbach, A. and Raab, S. and Reichardt, I. and Reimer, Anita and Reimer, Olaf and Renaud, Metz and de los Reyes, Raquel and Rieger, Frank and Romoli, C. and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, Vardan and Salek, D. and Sanchez, David M. and Santangelo, Andrea and Schlickeiser, Reinhard and Schuessler, F. and Schulz, A. and Schwanke, Ullrich and Schwarzburg, S. and Schwemmer, S. and Sol, H. and Spanier, Felix and Spengler, G. and Spies, Franziska and Stawarz, Lukasz and Steenkamp, Riaan and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Valerius, K. and van Eldik, C. and van Soelen, B. and Vasileiadis, Georges and Veh, J. and Venter, Christo and Viana, Aion and Vincent, P. and Vink, Jacco and V{\"o}lk, Heinrich J. and Volpe, Francesca and Vorster, Martine and Vuillaume, T. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and Ward, Martin and Weidinger, Matthias and Weitzel, Quirin and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, Ruizhi and Zabalza, Victor and Zaborov, Dmitry and Zacharias, M. and Zdziarski, A. A. and Zech, Alraune and Zechlin, Hannes -S.}, title = {H.E.S.S. detection of TeV emission from the interaction region between the supernova remnant G349.7+0.2 and a molecular cloud (vol 574, A100, 2015)}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {580}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201425070e}, pages = {2}, year = {2015}, language = {en} } @misc{RappKlugePenkaetal.2015, author = {Rapp, Michael A. and Kluge, Ulrike and Penka, Simone and Vardar, Azra and Aichberger, Marion Christina and Mundt, Adrian P. and Schouler-Ocak, Meryam and M{\"o}sko, Mike and Butler, Jeffrey and Meyer-Lindenberg, Andreas and Heinz, Andreas}, title = {When local poverty is more important than your income: Mental health in minorities in inner cities}, series = {World psychiatry}, volume = {14}, journal = {World psychiatry}, number = {2}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1723-8617}, doi = {10.1002/wps.20221}, pages = {249 -- 250}, year = {2015}, language = {en} } @article{FoerstnerBoettgerMoldavskietal.2023, author = {F{\"o}rstner, Bernd Rainer and B{\"o}ttger, Sarah Jane and Moldavski, Alexander and Bajbouj, Malek and Pfennig, Andrea and Manook, Andre and Ising, Marcus and Pittig, Andre and Heinig, Ingmar and Heinz, Andreas and Mathiak, Klaus and Schulze, Thomas G. and Schneider, Frank and Kamp-Becker, Inge and Meyer-Lindenberg, Andreas and Padberg, Frank and Banaschewski, Tobias and Bauer, Michael and Rupprecht, Rainer and Wittchen, Hans-Ulrich and Rapp, Michael A. and Tschorn, Mira}, title = {The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders}, series = {Frontiers in psychiatry}, volume = {14}, journal = {Frontiers in psychiatry}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-0640}, doi = {10.3389/fpsyt.2023.1161097}, pages = {10}, year = {2023}, abstract = {Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: \& beta; = -0.35; NVS: \& beta; = 0.39; CS: \& beta; = -0.12; SP: \& beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways.}, language = {en} } @article{HolzBoeckerSchlierJennenSteinmetzetal.2018, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Jennen-Steinmetz, Christine and Hohm, Erika and Buchmann, Arlette F. and Blomeyer, Dorothea and Baumeister, Sarah and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Early maternal care may counteract familial liability for psychopathology in the reward circuitry}, series = {Social Cognitive and Affective Neuroscience}, volume = {13}, journal = {Social Cognitive and Affective Neuroscience}, number = {11}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1749-5016}, doi = {10.1093/scan/nsy087}, pages = {1191 -- 1201}, year = {2018}, abstract = {Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants' previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.}, language = {en} } @article{BoeckerSchlierHolzHohmetal.2017, author = {Boecker-Schlier, Regina and Holz, Nathalie E. and Hohm, Erika and Zohsel, Katrin and Blomeyer, Dorothea and Buchmann, Arlette F. and Baumeister, Sarah and Wolf, Isabella and Esser, G{\"u}nter and Schmidt, Martin H. and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Association between pubertal stage at first drink and neural reward processing in early adulthood}, series = {Addiction biology}, volume = {22}, journal = {Addiction biology}, publisher = {Wiley}, address = {Hoboken}, issn = {1355-6215}, doi = {10.1111/adb.12413}, pages = {1402 -- 1415}, year = {2017}, abstract = {Puberty is a critical time period during human development. It is characterized by high levels of risk-taking behavior, such as increased alcohol consumption, and is accompanied by various neurobiological changes. Recent studies in animals and humans have revealed that the pubertal stage at first drink (PSFD) significantly impacts drinking behavior in adulthood. Moreover, neuronal alterations of the dopaminergic reward system have been associated with alcohol abuse or addiction. This study aimed to clarify the impact of PSFD on neuronal characteristics of reward processing linked to alcohol-related problems. One hundred sixty-eight healthy young adults from a prospective study covering 25 years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. PSFD was determined according to the age at menarche or Tanner stage of pubertal development, respectively. Alcohol-related problems in early adulthood were assessed with the Alcohol Use Disorder Identification Test (AUDIT). During reward anticipation, decreased fMRI activation of the frontal cortex and increased preparatory EEG activity (contingent negative variation) occurred with pubertal compared to postpubertal first alcohol intake. Moreover, alcohol-related problems during early adulthood were increased in pubertal compared to postpubertal beginners, which was mediated by neuronal activation of the right medial frontal gyrus. At reward delivery, increased fMRI activation of the left caudate and higher feedback-related EEG negativity were detected in pubertal compared to postpubertal beginners. Together with animal findings, these results implicate PSFD as a potential modulator of psychopathology, involving altered reward anticipation. Both PSFD timing and reward processing might thus be potential targets for early prevention and intervention.}, language = {en} } @article{SchuchStubbsMeyeretal.2019, author = {Schuch, Felipe B. and Stubbs, Brendon and Meyer, Jacob and Heissel, Andreas and Zech, Philipp and Vancampfort, Davy and Rosenbaum, Simon and Deenik, Jeroen and Firth, Joseph and Ward, Philip B. and Carvalho, Andre F. and Hiles, Sarah A.}, title = {Physical activity protects from incident anxiety: A meta-analysis of prospective cohort studies}, series = {Depression and anxiety}, volume = {36}, journal = {Depression and anxiety}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {1091-4269}, doi = {10.1002/da.22915}, pages = {846 -- 858}, year = {2019}, abstract = {Background Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta-analysis has been conducted. Aims To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow-up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted and heterogeneity was explored using subgroup and meta-regression analysis. Results Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1\%) followed for 357,424 person-years, people with high self-reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95\% confidence level [95\% CI] = 0.62, 0.88; crude OR = 0.80; 95\% CI = 0.69, 0.92). High self-reported PA was protective against the emergence of agoraphobia (AOR = 0.42; 95\% CI = 0.18, 0.98) and posttraumatic stress disorder (AOR = 0.57; 95\% CI = 0.39, 0.85). The protective effects for anxiety were evident in Asia (AOR = 0.31; 95\% CI = 0.10, 0.96) and Europe (AOR = 0.82; 95\% CI = 0.69, 0.97); for children/adolescents (AOR = 0.52; 95\% CI = 0.29, 0.90) and adults (AOR = 0.81; 95\% CI = 0.69, 0.95). Results remained robust when adjusting for confounding factors. Overall study quality was moderate to high (mean NOS = 6.7 out of 9). Conclusion Evidence supports the notion that self-reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.}, language = {en} } @book{MeyerSmirnovWeske2011, author = {Meyer, Andreas and Smirnov, Sergey and Weske, Mathias}, title = {Data in business processes}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-144-8}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-53046}, publisher = {Universit{\"a}t Potsdam}, pages = {40}, year = {2011}, abstract = {Process and data are equally important for business process management. Process data is especially relevant in the context of automated business processes, process controlling, and representation of organizations' core assets. One can discover many process modeling languages, each having a specific set of data modeling capabilities and the level of data awareness. The level of data awareness and data modeling capabilities vary significantly from one language to another. This paper evaluates several process modeling languages with respect to the role of data. To find a common ground for comparison, we develop a framework, which systematically organizes process- and data-related aspects of the modeling languages elaborating on the data aspects. Once the framework is in place, we compare twelve process modeling languages against it. We generalize the results of the comparison and identify clusters of similar languages with respect to data awareness.}, language = {de} } @phdthesis{MeyerAurich1999, author = {Meyer-Aurich, Andreas}, title = {Entwicklung von umwelt- und naturschutzgerechten Verfahren der landwirtschaftlichen Landnutzung f{\"u}r das Biosph{\"a}renreservat Schorfheide-Chorin}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-0000016}, school = {Universit{\"a}t Potsdam}, year = {1999}, abstract = {Mit der vorliegenden Arbeit werden exemplarisch Chancen und Grenzen der Integration von Umwelt- und Naturschutz in Verfahren der ackerbaulichen Landnutzung aufgezeigt. Die Umsetzung von Zielen des Umwelt- und Naturschutzes in Verfahren der Landnutzung ist mit verschiedenen Schwierigkeiten verbunden. Diese liegen zum einen in der Konkretisierung der Ziele, um diese umsetzen zu k{\"o}nnen, zum anderen in vielfach unzul{\"a}nglichem Wissen {\"u}ber den Zusammenhang zwischen unterschiedlichen Formen der Landnutzung und insbesondere den biotischen Naturschutzzielen. Zun{\"a}chst wird die Problematik der Zielfestlegung und Konkretisierung er{\"o}rtert. Das Umweltqualit{\"a}tszielkonzept von F{\"u}rst et al. (1992) stellt einen Versuch dar, Ziele des Umwelt- und Naturschutzes zu konkretisieren. Dieses Konzept haben Heidt et al. (1997) auf einen Landschaftsausschnitt von ca. 6000 ha im Biosph{\"a}renreservat Schorfheide-Chorin im Nordosten Brandenburgs angewendet. Eine Auswahl der von Heidt et al. (1997) formulierten Umweltqualit{\"a}tsziele bildet die Basis dieser Arbeit. F{\"u}r die ausgew{\"a}hlten Umweltqualit{\"a}tsziele wurden wesentliche Einflussfaktoren der Landnutzung identifiziert und ein Bewertungssystem entwickelt, mit dem die Auswirkungen von landwirtschaftlichen Anbauverfahren auf diese Umweltqualit{\"a}tsziele abgebildet werden k{\"o}nnen. Die praktizierte Landnutzung von 20 Betrieben im Biosph{\"a}renreservat Schorfheide-Chorin wurde von 1994 bis 1997 hinsichtlich ihrer Auswirkungen auf die Umweltqualit{\"a}tsziele analysiert. Die Analyse ergab ein sehr differenziertes Bild, das zum Teil Unterschiede in der Auswirkung auf die Umweltqualit{\"a}tsziele f{\"u}r den Anbau einzelner Kulturen oder f{\"u}r bestimmte Betriebstypen zeigte. Es zeigte sich aber auch, dass es bei der Gestaltung des Anbaus einzelner Kulturarten große Unterschiede gab, die f{\"u}r Umweltqualit{\"a}tsziele Bedeutung haben. Neben der Analyse der Landnutzung im Biosph{\"a}renreservat Schorfheide-Chorin wurde ein System entwickelt, mit dem die modellhafte Abbildung von Verfahren der Landnutzung m{\"o}glich ist. Die Modellverfahren wurden in eine umfangreiche Datenbank eingebunden. Sie wurden mit Hilfe eines Fuzzy- Regelsystems hinsichtlich ihrer Auswirkungen auf die Umweltqualit{\"a}tsziele bewertet. Die systematisch bewerteten Verfahren wurden in ein Betriebsmodell integriert, womit eine weitergehende Analyse der Zielbeziehungen und die Berechnung von Szenarien mit unterschiedlichen Rahmenbedingungen erm{\"o}glicht wurde. Die Analyse der Beziehung verschiedener Ziele zueinander (Zieldivergenz, Zielkonvergenz) zeigte, dass sich mit der Verfolgung vieler Umweltqualit{\"a}tsziele auch positive Effekte f{\"u}r andere Umweltqualit{\"a}tsziele ergaben. Teilweise konnte allerdings auch eine Zieldivergenz festgestellt werden, die auf m{\"o}gliche Zielkonflikte hinweist. Bei der Analyse der Szenarienergebnisse zeigte sich, dass die vorgeschlagenen Ver{\"a}nderungen von Rahmenbedingungen vielfach eine Verschlechterung f{\"u}r verschiedene Umweltqualit{\"a}tsziele mit sich bringen. Eine Ursache daf{\"u}r liegt darin, dass bei der Definition der Szenarien die Bedeutung der Stilllegungen untersch{\"a}tzt wurde.}, language = {de} } @book{MeyerPufahlFahlandetal.2013, author = {Meyer, Andreas and Pufahl, Luise and Fahland, Dirk and Weske, Mathias}, title = {Modeling and enacting complex data dependencies in business processes}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-245-2}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-65103}, publisher = {Universit{\"a}t Potsdam}, pages = {40}, year = {2013}, abstract = {Enacting business processes in process engines requires the coverage of control flow, resource assignments, and process data. While the first two aspects are well supported in current process engines, data dependencies need to be added and maintained manually by a process engineer. Thus, this task is error-prone and time-consuming. In this report, we address the problem of modeling processes with complex data dependencies, e.g., m:n relationships, and their automatic enactment from process models. First, we extend BPMN data objects with few annotations to allow data dependency handling as well as data instance differentiation. Second, we introduce a pattern-based approach to derive SQL queries from process models utilizing the above mentioned extensions. Therewith, we allow automatic enactment of data-aware BPMN process models. We implemented our approach for the Activiti process engine to show applicability.}, language = {en} } @book{KloseKlostermannEngelmannetal.2006, author = {Klose, Dagmar and Klostermann, Anke and Engelmann, Anna-Maria and Jeltsch, Gesche and Dowall, Kathrin and Meyer, Georg and Glados, Andrea and Fischer, Raul and Hoffmann, Katrin and Kaiser, Christoph and Ladewig, Marco and Skouras, Andreas and Wienert, Christian and Wilkening, Gregor and Klaudius, Mathias and Goldbeck, Johanna and Duch, Sven and Werfel, Claudia and Viebig, Wenke and Neumann, Katharina and Dammnik, Sabine}, title = {Antike so fern und doch so nah}, editor = {Klose, Dagmar}, isbn = {978-3-939469-37-7}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-11179}, publisher = {Universit{\"a}t Potsdam}, year = {2006}, abstract = {Historisches Denken entwickeln am Gegenstand der altorientalischen,griechischen und r{\"o}mischen Antike, das ist Anliegen der didaktischen Handreichung f{\"u}r die gymnasiale Oberstufe. Didaktisch-methodische {\"U}berlegungen, Sachinformationen und ein handlungsorientierter Materialteil bieten f{\"u}r Lehrer und Sch{\"u}ler ein ideenreiches Angebot zur Auswahl f{\"u}r einen interessegeleiteten Geschichtsunterricht.}, language = {de} } @article{MeyerMarkovaPohletal.2018, author = {Meyer, S{\"o}ren and Markova, Mariya and Pohl, Gabriele and Marschall, Talke Anu and Pivovarova, Olga and Pfeiffer, Andreas F. H. and Schwerdtle, Tanja}, title = {Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum}, series = {Journal of trace elements in medicine and biology}, volume = {49}, journal = {Journal of trace elements in medicine and biology}, publisher = {Elsevier GMBH}, address = {M{\"u}nchen}, issn = {0946-672X}, doi = {10.1016/j.jtemb.2018.05.012}, pages = {157 -- 163}, year = {2018}, abstract = {Multi-element determination in human samples is very challenging. Especially in human intervention studies sample volumes are often limited to a few microliters and due to the high number of samples a high-throughput is indispensable. Here, we present a state-of-the-art ICP-MS/MS-based method for the analysis of essential (trace) elements, namely Mg, Ca, Fe, Cu, Zn, Mo, Se and I, as well as food-relevant toxic elements such as As and Cd. The developed method was validated regarding linearity of the calibration curves, method LODs and LOQs, selectivity and trueness as well as precision. The established reliable method was applied to quantify the element serum concentrations of participants of a human intervention study (LeguAN). The participants received isocaloric diets, either rich in plant protein or in animal protein. While the serum concentrations of Mg and Mo increased in participants receiving the plant protein-based diet (above all legumes), the Se concentration in serum decreased. In contrast, the animal protein-based diet, rich in meat and dairy products, resulted in an increased Se concentration in serum.}, language = {en} } @article{JainWheelerEssetal.2019, author = {Jain, Varun and Wheeler, Joshua J. and Ess, Daniel H. and Noack, Sebastian and Vacogne, Charlotte D. and Schlaad, Helmut and Bahr, Stephan and Dietrich, Paul and Meyer, Michael and Thissen, Andreas and Linford, Matthew R.}, title = {Poly(gamma-benzyl l-glutamate), by near-ambient pressure XPS}, series = {Surface science spectra : SSS : an international journal \& database devoted to archiving spectra from surfaces \& interfaces}, volume = {26}, journal = {Surface science spectra : SSS : an international journal \& database devoted to archiving spectra from surfaces \& interfaces}, number = {2}, publisher = {American Institute of Physics}, address = {Melville}, issn = {1055-5269}, doi = {10.1116/1.5109121}, pages = {10}, year = {2019}, abstract = {Near-ambient pressure x-ray photoelectron spectroscopy (NAP-XPS) is a less traditional form of XPS that allows samples to be analyzed at relatively high pressures, i. e., at greater than 2500 Pa. In this study, poly(.- benzyl L- glutamate) (PBLG) with a molar mass of 11.3 kg/mol was analyzed by NAP-XPS; here, we show the survey, C 1s, N 1s, and O 1s narrow scans of PBLG. The C 1s peak envelope was fitted in three different ways, to five, six, or seven synthetic peaks. In each fit, there was also a shake-up signal. The O 1s narrow scan was well fit with three peaks: CZO and CvO in a 1:2 ratio from the polymer, and a higher energy signal from water vapor. Hartree-Fock orbital energies of a model monomer served as a guide to an additional fit of the C 1s envelope.}, language = {en} } @misc{SchultzKrieselKenngottetal.2001, author = {Schultz, Steffen-R. and Kriesel, Peter and Kenngott, Eva-Maria and Franz, Norbert and Wernet, Andreas and Tristram, Hildegard L. C. and Klein, Armin and Meyer, Till and Erler, Livia and {\"U}belacker, Tanja}, title = {Portal = Streitfall: Unterrichtsfach Lebensgestaltung, Ethik, Religionskunde}, number = {11/2001}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-43944}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-439444}, pages = {35}, year = {2001}, abstract = {Aus dem Inhalt: - Streitfall: Unterrichtsfach Lebensgestaltung, Ethik, Religionskunde - Hasso-Plattner-Institut eingeweiht - Psychologen entwickeln Intelligenztest f{\"u}r Kinder - Studentisches Kulturzentrum in der Stadt}, language = {de} } @misc{AnlaufLayusFreweretal.2008, author = {Anlauf, Lena and Layus, Rosario Figari and Frewer, Andreas and Furtmayr, Holger and Georgas, Margarita and Golovnenkov, Pavel and Heß, Asmus and Kintzel, Yvonne and Kotzur, Markus and Kr{\´a}sa, Kerstin and Menke, Christoph and Meyer, Gunda and Moewes, Udo and Reiß, Tim and Rothhaar, Markus and Weiß, Norman}, title = {MenschenRechtsMagazin : Informationen | Meinungen | Analysen}, volume = {13}, number = {2}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1434-2820}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-36208}, year = {2008}, abstract = {Themenschwerpunkt: Medizin und Menschenrechte - 60 Jahre Allgemeine Erkl{\"a}rung der Menschenrechte - Reflexionen zur Entstehungsgeschichte, Ideengeschichte und Wirkungsgeschichte - Zum Wohle des Vaterlands - Zur „Erkl{\"a}rung zu Menschenrechten und Menschenw{\"u}rde" des World Russian People´s Council - Bericht {\"u}ber die Arbeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2007 - Teil II}, language = {de} } @article{PatelNoackVacogneetal.2019, author = {Patel, Dhananjay I. and Noack, Sebastian and Vacogne, Charlotte D. and Schlaad, Helmut and Bahr, Stephan and Dietrich, Paul and Meyer, Michael and Thissen, Andreas and Linford, Matthew R.}, title = {Poly(L-lactic acid), by near-ambient pressure XPS}, series = {Surface Science Spectra}, volume = {26}, journal = {Surface Science Spectra}, number = {2}, publisher = {American Institute of Physics}, address = {Melville}, issn = {1055-5269}, doi = {10.1116/1.5110309}, pages = {8}, year = {2019}, abstract = {Near ambient pressure - x-ray photoelectron spectroscopy (NAP-XPS) is a less traditional form of XPS that allows samples to be analyzed at relatively high pressures, i.e., at 2500Pa or higher. With NAP-XPS, one can analyze moderately volatile liquids, biological samples, porous materials, and/or polymeric materials that outgas significantly. In this submission we show C 1s, O 1s, and survey NAP-XPS spectra from poly(L-lactic acid). The C 1s and O 1s envelopes were fit with three and two Gaussian-Lorentzian sum functions, respectively. Water vapor (800Pa) was used as the residual gas for charge compensation, which was confirmed by the sharp peak at 535.0 eV in the O 1s narrow scan. The uniqueness plot corresponding to the C 1s fit shows that the fit parameters had statistical significance. C 1s and O 1s spectra of PLLA damaged by exposure to x-rays for ca. 1 hour are also included. Published by the AVS.}, language = {en} } @article{GrimmMeyerCzaplaetal.2013, author = {Grimm, Christiane and Meyer, Thomas and Czapla, Sylvia and Nikolaus, J{\"o}rg and Scheidt, Holger A. and Vogel, Alexander and Herrmann, Andreas and Wessig, Pablo and Huster, Daniel and M{\"u}ller, Peter}, title = {Structure and dynamics of molecular rods in membranes application of a Spin-Labeled rod}, series = {Chemistry - a European journal}, volume = {19}, journal = {Chemistry - a European journal}, number = {8}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0947-6539}, doi = {10.1002/chem.201202500}, pages = {2703 -- 2710}, year = {2013}, abstract = {Molecular rods consisting of a hydrophobic backbone and terminally varying functional groups have been synthesized for applications for the functionalization of membranes. In the present study, we employ a spin-labeled analogue of a recently described new class of molecular rods to characterize their dynamic interactions with membranes. By using the different approaches of ESR and NMR spectroscopy, we show that the spin moiety of the membrane-embedded spin-labeled rod is localized in the upper chain/glycerol region of membranes of different compositions. The rod is embedded within the membrane in a tilted orientation to adjust for the varying hydrophobic thicknesses of these bilayers. This orientation does not perturb the membrane structure. The water solubility of the rod is increased significantly in the presence of certain cyclodextrins. These cyclodextrins also allow the rods to be extracted from the membrane and incorporated into preformed membranes. The latter will improve the future applications of these rods in cellular systems as stable membrane-associated anchors for the functionalization of membrane surfaces.}, language = {en} } @article{HolzBuchmannBoeckerSchlieretal.2015, author = {Holz, Nathalie E. and Buchmann, Arlette F. and Boecker-Schlier, Regina and Blomeyer, Dorothea and Baumeister, Sarah and Wolf, Isabella and Rietschel, Marcella and Witt, Stephanie H. and Plichta, Michael M. and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume}, series = {Brain structure \& function}, volume = {220}, journal = {Brain structure \& function}, number = {3}, publisher = {Springer}, address = {Heidelberg}, issn = {1863-2653}, doi = {10.1007/s00429-014-0729-5}, pages = {1355 -- 1368}, year = {2015}, abstract = {Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations in stress-sensitive brain systems. Functional magnetic resonance imaging during an emotional face-matching task was performed in 153 healthy young adults (66 males) from a high-risk community sample followed since birth. Voxel-based morphometry was applied to study structural alterations and DNA was genotyped for FKBP5 rs1360780. Childhood adversity was measured using retrospective self-report (Childhood Trauma Questionnaire) and by a standardized parent interview assessing childhood family adversity. Depression was assessed by the Beck Depression Inventory. There was a main effect of FKBP5 on the left amygdala, with T homozygotes showing the highest activity, largest volume and increased coupling with the left hippocampus and the orbitofrontal cortex (OFC). Moreover, amygdala-OFC coupling proved to be associated with depression in this genotype. In addition, our results support previous evidence of a gene-environment interaction on right amygdala activity with respect to retrospective assessment of childhood adversity, but clarify that this does not generalize to the prospective assessment. These findings indicated that activity in T homozygotes increased with the level of adversity, whereas the opposite pattern emerged in C homozygotes, with CT individuals being intermediate. The present results point to a functional involvement of FKBP5 in intermediate phenotypes associated with emotional processing, suggesting a possible mechanism for this gene in conferring susceptibility to stress-related disorders.}, language = {en} } @misc{BoeckerSchlierHolzBuchmannetal.2014, author = {Boecker-Schlier, Regina and Holz, Nathalie E. and Buchmann, Arlette F. and Blomeyer, Dorothea and Plichta, Michael M. and Wolf, Isabella and Baumeister, Sarah and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Impact of early life adversity on reward processing in young adults: EEG-fMRI results from a prospective study over 25 years}, series = {PLoS one}, volume = {9}, journal = {PLoS one}, number = {10}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0112155}, pages = {1}, year = {2014}, language = {en} } @article{HerzbergMeyerWeske2015, author = {Herzberg, Nico and Meyer, Andreas and Weske, Mathias}, title = {Improving business process intelligence by observing object state transitions}, series = {Data \& knowledge engineering}, volume = {98}, journal = {Data \& knowledge engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0169-023X}, doi = {10.1016/j.datak.2015.07.008}, pages = {144 -- 164}, year = {2015}, abstract = {During the execution of business processes several events happen that are recorded in the company's information systems. These events deliver insights into process executions so that process monitoring and analysis can be performed resulting, for instance, in prediction of upcoming process steps or the analysis of the run time of single steps. While event capturing is trivial when a process engine with integrated logging capabilities is used, manual process execution environments do not provide automatic logging of events, so that typically external devices, like bar code scanners, have to be used. As experience shows, these manual steps are error-prone and induce additional work. Therefore, we use object state transitions as additional monitoring information, so-called object state transition events. Based on these object state transition events, we reason about the enablement and termination of activities and provide the basis for process monitoring and analysis in terms of a large event log. In this paper, we present the concept to utilize information from these object state transition events for capturing process progress. Furthermore, we discuss a methodology to create the required design time artifacts that then are used for monitoring at run time. In a proof-of-concept implementation, we show how the design time and run time side work and prove applicability of the introduced concept of object state transition events. (C) 2015 Elsevier B.V. All rights reserved.}, language = {en} } @article{HolzBoeckerSchlierBaumeisteretal.2014, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Baumeister, Sarah and Hohm, Erika and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Hohmann, Sarah and Wolf, Isabella and Plichta, Michael M. and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Effect of prenatal exposure to tobacco smoke on inhibitory control neuroimaging results from a 25-Year prospective study}, series = {JAMA psychiatry}, volume = {71}, journal = {JAMA psychiatry}, number = {7}, publisher = {American Veterinary Medical Association}, address = {Chicago}, issn = {2168-622X}, doi = {10.1001/jamapsychiatry.2014.786}, pages = {786 -- 796}, year = {2014}, abstract = {IMPORTANCE: There is accumulating evidence relating maternal smoking during pregnancy to attention-deficit/hyperactivity disorder (ADHD) without elucidating specific mechanisms. Research investigating the neurobiological underpinnings of this disorder has implicated deficits during response inhibition. Attempts to uncover the effect of prenatal exposure to nicotine on inhibitory control may thus be of high clinical importance. MAIN OUTCOMES AND MEASURES: Functional magnetic resonance imaging response, morphometric data, lifetime ADHD symptoms, and novelty seeking. RESULTS: Participants prenatally exposed to nicotine exhibited a weaker response in the anterior cingulate cortex (t(168) = 4.46; peak Montreal Neurological Institute [MNI] coordinates x = -2, y = 20, z = 30; familywise error [FWE]-corrected P = .003), the right inferior frontal gyrus (t(168) = 3.65; peak MNI coordinates x = 44, y = 38, z = 12; FWE-corrected P = .04), the left inferior frontal gyrus (t(168) = 4.09; peak MNI coordinates x = -38, y = 36, z = 8; FWE-corrected P = .009), and the supramarginal gyrus (t(168) = 5.03; peak MNI coordinates x = 64, y = -28, z = 22; FWE-corrected P = .02) during the processing of the NoGo compared to neutral stimuli, while presenting a decreased volume in the right inferior frontal gyrus. These findings were obtained irrespective of the adjustment of confounders, ADHD symptoms, and novelty seeking. There was an inverse relationship between inferior frontal gyrus activity and ADHD symptoms and between anterior cingulate cortex activity and novelty seeking. CONCLUSIONS AND RELEVANCE: These findings point to a functional involvement of prenatal exposure to tobacco smoke in neural alterations similar to ADHD, which underlines the importance of smoking prevention treatments.}, language = {en} } @article{MeyerPufahlBatoulisetal.2015, author = {Meyer, Andreas and Pufahl, Luise and Batoulis, Kimon and Fahland, Dirk and Weske, Mathias}, title = {Automating data exchange in process choreographies}, series = {Information systems}, volume = {53}, journal = {Information systems}, publisher = {Elsevier}, address = {Oxford}, issn = {0306-4379}, doi = {10.1016/j.is.2015.03.008}, pages = {296 -- 329}, year = {2015}, abstract = {Communication between organizations is formalized as process choreographies in daily business. While the correct ordering of exchanged messages can be modeled and enacted with current choreography techniques, no approach exists to describe and automate the exchange of data between processes in a choreography using messages. This paper describes an entirely model-driven approach for BPMN introducing a few concepts that suffice to model data retrieval, data transformation, message exchange, and correlation four aspects of data exchange. For automation, this work utilizes a recent concept to enact data dependencies in internal processes. We present a modeling guideline to derive local process models from a given choreography; their operational semantics allows to correctly enact the entire choreography from the derived models only including the exchange of data. Targeting on successful interactions, we discuss means to ensure correct process choreography modeling. Finally, we implemented our approach by extending the camunda BPM platform with our approach and show its feasibility by realizing all service interaction patterns using only model-based concepts. (C) 2015 Elsevier Ltd. All rights reserved.}, language = {en} } @article{MeynersWawrzinekKraemeretal.2014, author = {Meyners, Christian and Wawrzinek, Robert and Kraemer, Andreas and Hinz, Steffen and Wessig, Pablo and Meyer-Almes, Franz-Josef}, title = {A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) ligand probe}, series = {Analytical \& bioanalytical chemistry}, volume = {406}, journal = {Analytical \& bioanalytical chemistry}, number = {20}, publisher = {Springer}, address = {Heidelberg}, issn = {1618-2642}, doi = {10.1007/s00216-014-7886-5}, pages = {4889 -- 4897}, year = {2014}, abstract = {High-throughput assays for drug screening applications have to fulfill particular specifications. Besides the capability to identify even compounds with low potency, one of the major issues is to minimize the number of false-positive hits in a screening campaign in order to reduce the logistic effort for the subsequent cherry picking and confirmation procedure. In this respect, fluorescence lifetime (FLT) appears as an ideal readout parameter that is supposed to be robust against autofluorescent and light-absorbing compounds, the most common source of systematic false positives. The extraordinary fluorescence features of the recently discovered [1,3]dioxolo[4,5-f][1,3]benzodioxole dyes were exploited to develop an FLT-based binding assay with exceptionally robust readout. The assay setup was comprehensively validated and shown to comply not only with all requirements for a powerful high-throughput screening assay but also to be suitable to determine accurate binding constants for inhibitors against enzymes of the histone deacetylase family. Using the described binding assay, the first inhibitors against three members of this enzyme family from Pseudomonas aeruginosa were identified. The compounds were characterized in terms of potency and selectivity profile. The novel ligand probe should also be applicable to other homologues of the histone deacetylase family that are inhibited by N-hydroxy-N'-phenyloctandiamide.}, language = {en} } @article{BoeckerSchlierHolzBuchmannetal.2014, author = {Boecker-Schlier, Regina and Holz, Nathalie E. and Buchmann, Arlette F. and Blomeyer, Dorothea and Plichta, Michael M. and Wolf, Isabella and Baumeister, Sarah and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Impact of early life adversity on reward processing in young adults: EEG-fMRI results from a prospective study over 25 years}, series = {PLoS one}, volume = {9}, journal = {PLoS one}, number = {8}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0104185}, pages = {13}, year = {2014}, abstract = {Several lines of evidence have implicated the mesolimbic dopamine reward pathway in altered brain function resulting from exposure to early adversity. The present study examined the impact of early life adversity on different stages of neuronal reward processing later in life and their association with a related behavioral phenotype, i.e. attention deficit/hyperactivity disorder (ADHD). 162 healthy young adults (mean age = 24.4 years; 58\% female) from an epidemiological cohort study followed since birth participated in a simultaneous EEG-fMRI study using a monetary incentive delay task. Early life adversity according to an early family adversity index (EFA) and lifetime ADHD symptoms were assessed using standardized parent interviews conducted at the offspring's age of 3 months and between 2 and 15 years, respectively. fMRI region-of-interest analysis revealed a significant effect of EFA during reward anticipation in reward-related areas (i.e. ventral striatum, putamen, thalamus), indicating decreased activation when EFA increased. EEG analysis demonstrated a similar effect for the contingent negative variation (CNV), with the CNV decreasing with the level of EFA. In contrast, during reward delivery, activation of the bilateral insula, right pallidum and bilateral putamen increased with EFA. There was a significant association of lifetime ADHD symptoms with lower activation in the left ventral striatum during reward anticipation and higher activation in the right insula during reward delivery. The present findings indicate a differential long-term impact of early life adversity on reward processing, implicating hyporesponsiveness during reward anticipation and hyperresponsiveness when receiving a reward. Moreover, a similar activation pattern related to lifetime ADHD suggests that the impact of early life stress on ADHD may possibly be mediated by a dysfunctional reward pathway.}, language = {en} } @article{HolzBoeckerSchlierJennenSteinmetzetal.2016, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Jennen-Steinmetz, Christine and Buchmann, Arlette F. and Blomeyer, Dorothea and Baumeister, Sarah and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Positive coping styles and perigenual ACC volume: two related mechanisms for conferring resilience?}, series = {Frontiers in human neuroscience}, volume = {11}, journal = {Frontiers in human neuroscience}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1749-5016}, doi = {10.1093/scan/nsw005}, pages = {813 -- 820}, year = {2016}, abstract = {Stress exposure has been linked to increased rates of depression and anxiety in adults, particularly in females, and has been associated with maladaptive changes in the anterior cingulate cortex (ACC), which is an important brain structure involved in internalizing disorders. Coping styles are important mediators of the stress reaction by establishing homeostasis, and may thus confer resilience to stress-related psychopathology. Anatomical scans were acquired in 181 healthy participants at age 25 years. Positive coping styles were determined using a self-report questionnaire (German Stress Coping Questionnaire, SVF78) at age 22 years. Adult anxiety and depression symptoms were assessed at ages 22, 23 and 25 years with the Young Adult Self-Report. Information on previous internalizing diagnoses was obtained by diagnostic interview (2-19 years). Positive coping styles were associated with increased ACC volume. ACC volume and positive coping styles predicted anxiety and depression in a sex-dependent manner with increased positive coping and ACC volume being related to lower levels of psychopathology in females, but not in males. These results remained significant when controlled for previous internalizing diagnoses. These findings indicate that positive coping styles and ACC volume are two linked mechanisms, which may serve as protective factors against internalizing disorders.}, language = {en} } @article{HolzBoeckerSchlierBuchmannetal.2016, author = {Holz, Nathalie and Boecker-Schlier, Regina and Buchmann, Arlette F. and Blomeyer, Dorothea and Baumeister, Sarah and Hohmann, Sarah and Jennen-Steinmetz, Christine and Wolf, Isabella and Rietschel, Marcella and Witt, Stephanie H. and Plichta, Michael M. and Meyer-Lindenberg, Andreas and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Evidence for a Sex-Dependent MAOAx Childhood Stress Interaction in the Neural Circuitry of Aggression}, series = {Cerebral cortex}, volume = {26}, journal = {Cerebral cortex}, publisher = {Oxford Univ. Press}, address = {Cary}, issn = {1047-3211}, doi = {10.1093/cercor/bhu249}, pages = {904 -- 914}, year = {2016}, abstract = {Converging evidence emphasizes the role of an interaction between monoamine oxidase A (MAOA) genotype, environmental adversity, and sex in the pathophysiology of aggression. The present study aimed to clarify the impact of this interaction on neural activity in aggression-related brain systems. Functional magnetic resonance imaging was performed in 125 healthy adults from a high-risk community sample followed since birth. DNA was genotyped for the MAOA-VNTR (variable number of tandem repeats). Exposure to childhood life stress (CLS) between the ages of 4 and 11 years was assessed using a standardized parent interview, aggression by the Youth/Young Adult Self-Report between the ages of 15 and 25 years, and the VIRA-R (Vragenlijst Instrumentele En Reactieve Agressie) at the age of 15 years. Significant interactions were obtained between MAOA genotype, CLS, and sex relating to amygdala, hippocampus, and anterior cingulate cortex (ACC) response, respectively. Activity in the amygdala and hippocampus during emotional face-matching increased with the level of CLS in male MAOA-L, while decreasing in male MAOA-H, with the reverse pattern present in females. Findings in the opposite direction in the ACC during a flanker NoGo task suggested that increased emotional activity coincided with decreased inhibitory control. Moreover, increasing amygdala activity was associated with higher Y(A)SR aggression in male MAOA-L and female MAOA-H carriers. Likewise, a significant association between amygdala activity and reactive aggression was detected in female MAOA-H carriers. The results point to a moderating role of sex in the MAOAx CLS interaction for intermediate phenotypes of emotional and inhibitory processing, suggesting a possible mechanism in conferring susceptibility to violence-related disorders.}, language = {en} } @article{HohmannZohselBuchmannetal.2016, author = {Hohmann, Sarah and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Holz, Nathalie and Boecker-Schlier, Regina and Jennen-Steinmetz, Christine and Rietschel, Marcella and Witt, Stephanie H. and Schmidt, Martin H. and Esser, G{\"u}nter and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Hohm, Erika and Laucht, Manfred}, title = {Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood}, series = {Journal of neural transmission}, volume = {123}, journal = {Journal of neural transmission}, publisher = {Springer}, address = {Wien}, issn = {0300-9564}, doi = {10.1007/s00702-016-1582-x}, pages = {885 -- 894}, year = {2016}, abstract = {Findings on the etiology of aggressive behavior have provided evidence for an effect both of genetic factors, such as variation in the monoamine oxidase A (MAOA) gene, and adverse environmental factors. Recent studies have supported the existence of gene × environment interactions, with early experiences playing a key role. In the present study, the effects of prenatal nicotine exposure, MAOA genotype and their interaction on aggressive behavior during young adulthood were examined. In a sample of 272 young adults (129 males, 143 females) from an epidemiological cohort study, smoking during pregnancy was measured with a standardized parent interview at the offspring's age of 3 months. Aggressive behavior was assessed between the ages of 19 and 25 years using the Young Adult Self-Report. DNA was genotyped for the MAOA 5\&\#8242; untranslated region variable number of tandem repeats polymorphism (VNTR). Results revealed a significant interaction between MAOA and smoking during pregnancy, indicating higher levels of aggressive behavior in young adults carrying the MAOA low-expressing genotype who had experienced prenatal nicotine exposure (n = 8, p = .025). In contrast, in carriers of the MAOA high-expressing genotype, maternal smoking during pregnancy had no effect on aggressive behavior during young adulthood (n = 20, p = .145). This study extends earlier findings demonstrating an interaction between MAOA genotype and prenatal nicotine exposure on aggressive behavior into young adulthood. The results point to the long-term adverse effects of smoking during pregnancy on the offspring's mental health, possibly underlining the importance of smoking cessation during pregnancy. According to the nature of the study (particularly sample size and power), analyses are exploratory and results need to be interpreted cautiously.}, language = {en} } @article{BoeckerSchlierHolzBuchmannetal.2016, author = {Boecker-Schlier, Regina and Holz, Nathalie E. and Buchmann, Arlette F. and Blomeyer, Dorothea and Plichta, Michael M. and Jennen-Steinmetz, Christine and Wolf, Isabella and Baumeister, Sarah and Treutleind, Jens and Rietschel, Marcella and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood}, series = {NeuroImage : a journal of brain function}, volume = {132}, journal = {NeuroImage : a journal of brain function}, publisher = {Elsevier}, address = {San Diego}, issn = {1053-8119}, doi = {10.1016/j.neuroimage.2016.02.006}, pages = {556 -- 570}, year = {2016}, abstract = {Background: Accumulating evidence suggests that altered dopamine transmission may increase the risk of mental disorders such as ADHD, schizophrenia or depression, possibly mediated by reward system dysfunction. This study aimed to clarify the impact of the COMT Val(158)Met polymorphism in interaction with environmental variation (G x E) on neuronal activity during reward processing. Methods: 168 healthy young adults from a prospective study conducted over 25 years participated in amonetary incentive delay task measured with simultaneous EEG-fMRI. DNA was genotyped for COMT, and childhood family adversity (CFA) up to age 11 was assessed by a standardized parent interview. Results: At reward delivery, a G x E revealed that fMRI activation for win vs. no-win trials in reward-related regions increased with the level of CFA in Met homozygotes as compared to Val/Met heterozygotes and Val homozygotes, who showed no significant effect. During the anticipation of monetary vs. verbal rewards, activation decreased with the level of CFA, which was also observed for EEG, in which the CNV declined with the level of CFA. Conclusions: These results identify convergent genetic and environmental effects on reward processing in a prospective study. Moreover, G x E effects during reward delivery suggest that stress during childhood is associated with higher reward sensitivity and reduced efficiency in processing rewarding stimuli in genetically at-risk individuals. Together with previous evidence, these results begin to define a specific system mediating interacting effects of early environmental and genetic risk factors, which may be targeted by early intervention and prevention. (C) 2016 Elsevier Inc. All rights reserved.}, language = {en} } @phdthesis{Meyer2015, author = {Meyer, Andreas}, title = {Data perspective in business process management}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-84806}, school = {Universit{\"a}t Potsdam}, pages = {xxi, 362}, year = {2015}, abstract = {Gesch{\"a}ftsprozessmanagement ist ein strukturierter Ansatz zur Modellierung, Analyse, Steuerung und Ausf{\"u}hrung von Gesch{\"a}ftsprozessen, um Gesch{\"a}ftsziele zu erreichen. Es st{\"u}tzt sich dabei auf konzeptionelle Modelle, von denen Prozessmodelle am weitesten verbreitet sind. Prozessmodelle beschreiben wer welche Aufgabe auszuf{\"u}hren hat, um das Gesch{\"a}ftsziel zu erreichen, und welche Informationen daf{\"u}r ben{\"o}tigt werden. Damit beinhalten Prozessmodelle Informationen {\"u}ber den Kontrollfluss, die Zuweisung von Verantwortlichkeiten, den Datenfluss und Informationssysteme. Die Automatisierung von Gesch{\"a}ftsprozessen erh{\"o}ht die Effizienz der Arbeitserledigung und wird durch Process Engines unterst{\"u}tzt. Daf{\"u}r werden jedoch Informationen {\"u}ber den Kontrollfluss, die Zuweisung von Verantwortlichkeiten f{\"u}r Aufgaben und den Datenfluss ben{\"o}tigt. W{\"a}hrend aktuelle Process Engines die ersten beiden Informationen weitgehend automatisiert verarbeiten k{\"o}nnen, m{\"u}ssen Daten manuell implementiert und gewartet werden. Dem entgegen verspricht ein modell-getriebenes Behandeln von Daten eine vereinfachte Implementation in der Process Engine und verringert gleichzeitig die Fehleranf{\"a}lligkeit dank einer graphischen Visualisierung und reduziert den Entwicklungsaufwand durch Codegenerierung. Die vorliegende Dissertation besch{\"a}ftigt sich mit der Modellierung, der Analyse und der Ausf{\"u}hrung von Daten in Gesch{\"a}ftsprozessen. Als formale Basis f{\"u}r die Prozessausf{\"u}hrung wird ein konzeptuelles Framework f{\"u}r die Integration von Prozessen und Daten eingef{\"u}hrt. Dieses Framework wird durch operationelle Semantik erg{\"a}nzt, die mittels einem um Daten erweiterten Petrinetz-Mapping vorgestellt wird. Die modellgetriebene Ausf{\"u}hrung von Daten muss komplexe Datenabh{\"a}ngigkeiten, Prozessdaten und den Datenaustausch ber{\"u}cksichtigen. Letzterer tritt bei der Kommunikation zwischen mehreren Prozessteilnehmern auf. Diese Arbeit nutzt Konzepte aus dem Bereich der Datenbanken und {\"u}berf{\"u}hrt diese ins Gesch{\"a}ftsprozessmanagement, um Datenoperationen zu unterscheiden, um Abh{\"a}ngigkeiten zwischen Datenobjekten des gleichen und verschiedenen Typs zu spezifizieren, um modellierte Datenknoten sowie empfangene Nachrichten zur richtigen laufenden Prozessinstanz zu korrelieren und um Nachrichten f{\"u}r die Prozess{\"u}bergreifende Kommunikation zu generieren. Der entsprechende Ansatz ist nicht auf eine bestimmte Prozessbeschreibungssprache begrenzt und wurde prototypisch implementiert. Die Automatisierung der Datenbehandlung in Gesch{\"a}ftsprozessen erfordert entsprechend annotierte und korrekte Prozessmodelle. Als Unterst{\"u}tzung zur Datenannotierung f{\"u}hrt diese Arbeit einen Algorithmus ein, welcher Informationen {\"u}ber Datenknoten, deren Zust{\"a}nde und Datenabh{\"a}ngigkeiten aus Kontrollflussinformationen extrahiert und die Prozessmodelle entsprechend annotiert. Allerdings k{\"o}nnen gew{\"o}hnlich nicht alle erforderlichen Informationen aus Kontrollflussinformationen extrahiert werden, da detaillierte Angaben {\"u}ber m{\"o}gliche Datenmanipulationen fehlen. Deshalb sind weitere Prozessmodellverfeinerungen notwendig. Basierend auf einer Menge von Objektlebenszyklen kann ein Prozessmodell derart verfeinert werden, dass die in den Objektlebenszyklen spezifizierten Datenmanipulationen automatisiert in ein Prozessmodell {\"u}berf{\"u}hrt werden k{\"o}nnen. Prozessmodelle stellen eine Abstraktion dar. Somit fokussieren sie auf verschiedene Teilbereiche und stellen diese im Detail dar. Solche Detailbereiche sind beispielsweise die Kontrollflusssicht und die Datenflusssicht, welche oft durch Aktivit{\"a}ts-zentrierte beziehungsweise Objekt-zentrierte Prozessmodelle abgebildet werden. In der vorliegenden Arbeit werden Algorithmen zur Transformation zwischen diesen Sichten beschrieben. Zur Sicherstellung der Modellkorrektheit wird das Konzept der „weak conformance" zur {\"U}berpr{\"u}fung der Konsistenz zwischen Objektlebenszyklen und dem Prozessmodell eingef{\"u}hrt. Dabei darf das Prozessmodell nur Datenmanipulationen enthalten, die auch in einem Objektlebenszyklus spezifiziert sind. Die Korrektheit wird mittels Soundness-{\"U}berpr{\"u}fung einer hybriden Darstellung ermittelt, so dass Kontrollfluss- und Datenkorrektheit integriert {\"u}berpr{\"u}ft werden. Um eine korrekte Ausf{\"u}hrung des Prozessmodells zu gew{\"a}hrleisten, m{\"u}ssen gefundene Inkonsistenzen korrigiert werden. Daf{\"u}r werden f{\"u}r jede Inkonsistenz alternative Vorschl{\"a}ge zur Modelladaption identifiziert und vorgeschlagen. Zusammengefasst, unter Einsatz der Ergebnisse dieser Dissertation k{\"o}nnen Gesch{\"a}ftsprozesse modellgetrieben ausgef{\"u}hrt werden unter Ber{\"u}cksichtigung sowohl von Daten als auch den zuvor bereits unterst{\"u}tzten Perspektiven bez{\"u}glich Kontrollfluss und Verantwortlichkeiten. Dabei wird die Modellerstellung teilweise mit automatisierten Algorithmen unterst{\"u}tzt und die Modellkonsistenz durch Datenkorrektheits{\"u}berpr{\"u}fungen gew{\"a}hrleistet.}, language = {en} } @article{HolzBoeckerSchlierHohmetal.2015, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Hohm, Erika and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Baumeister, Sarah and Hohmann, Sarah and Wolf, Isabella and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {The Long-Term Impact of Early Life Poverty on Orbitofrontal Cortex Volume in Adulthood: Results from a Prospective Study Over 25 Years}, series = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology}, volume = {40}, journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology}, number = {4}, publisher = {Nature Publ. Group}, address = {London}, issn = {0893-133X}, doi = {10.1038/npp.2014.277}, pages = {996 -- 1004}, year = {2015}, abstract = {Converging evidence has highlighted the association between poverty and conduct disorder (CD) without specifying neurobiological pathways. Neuroimaging research has emphasized structural and functional alterations in the orbitofrontal cortex (OFC) as one key mechanism underlying this disorder. The present study aimed to clarify the long-term influence of early poverty on OFC volume and its association with CD symptoms in healthy participants of an epidemiological cohort study followed since birth. At age 25 years, voxel-based morphometry was applied to study brain volume differences. Poverty (0 = non-exposed (N = 134), I = exposed (N = 33)) and smoking during pregnancy were determined using a standardized parent interview, and information on maternal responsiveness was derived from videotaped mother infant interactions at the age of 3 months. CD symptoms were assessed by diagnostic interview from 8 to 19 years of age. Information on life stress was acquired at each assessment and childhood maltreatment was measured using retrospective self-report at the age of 23 years. Analyses were adjusted for sex, parental psychopathology and delinquency, obstetric adversity, parental education, and current poverty. Individuals exposed to early life poverty exhibited a lower OFC volume. Moreover, we replicated previous findings of increased CD symptoms as a consequence of childhood poverty. This effect proved statistically mediated by OFC volume and exposure to life stress and smoking during pregnancy, but not by childhood maltreatment and maternal responsiveness. These findings underline the importance of studying the impact of early life adversity on brain alterations and highlight the need for programs to decrease income-related disparities.}, language = {en} } @book{FuessenichHerlinghausHuettemannetal.2024, author = {F{\"u}ssenich, Bert and Herlinghaus, Andreas and H{\"u}ttemann, Rainer and Meinert, Carsten and Meyer, Andr{\´e} and Osterloh-Konrad, Christine and R{\"o}der, Erik and Sch{\"o}n, Wolfgang}, title = {Unternehmenssteuerrecht}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, isbn = {978-3-504-20090-9}, doi = {10.9785/9783504387143}, pages = {XXIV, 908}, year = {2024}, abstract = {Das Unternehmenssteuerrecht gilt als schwierige Spezialmaterie. Wer in diesem praktisch wichtigen Rechtsgebiet den Durchblick behalten will, muss die relevanten Zusammenh{\"a}nge verstehen. Der stringente Aufbau und zahlreiche - zumeist an die BFH-Rechtsprechung angelehnte - Beispiele des „H{\"u}ttemann/Sch{\"o}n" erleichtern ebenso wie viele Querverweise den {\"U}berblick und die Durchdringung der Zusammenh{\"a}nge. Das Werk er{\"o}ffnet nicht nur interessierten Studierenden der Rechtswissenschaften, Wirtschaftswissenschaften und Steuerwissenschaften einen systematischen Zugang zum Unternehmenssteuerrecht. Er richtet sich auch an Praktiker, die bei ihrer beratenden und gestaltenden T{\"a}tigkeit auf hinreichende Kenntnisse und ein vertieftes Verst{\"a}ndnis dieses Rechtsgebiets angewiesen sind.}, language = {de} } @article{HolzBoeckerSchlierBuchmannetal.2017, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Baumeister, Sarah and Plichta, Michael M. and Cattrell, Anna and Schumann, Gunter and Esser, G{\"u}nter and Schmidt, Martin and Buitelaar, Jan and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder}, series = {Frontiers in human neuroscience}, volume = {12}, journal = {Frontiers in human neuroscience}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1749-5016}, doi = {10.1093/scan/nsw120}, pages = {261 -- 272}, year = {2017}, abstract = {Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2-19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years). CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.}, language = {en} } @book{MeyerWeske2014, author = {Meyer, Andreas and Weske, Mathias}, title = {Weak conformance between process models and synchronized object life cycles}, number = {91}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-303-9}, issn = {1613-5652}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-71722}, publisher = {Universit{\"a}t Potsdam}, pages = {31}, year = {2014}, abstract = {Process models specify behavioral execution constraints between activities as well as between activities and data objects. A data object is characterized by its states and state transitions represented as object life cycle. For process execution, all behavioral execution constraints must be correct. Correctness can be verified via soundness checking which currently only considers control flow information. For data correctness, conformance between a process model and its object life cycles is checked. Current approaches abstract from dependencies between multiple data objects and require fully specified process models although, in real-world process repositories, often underspecified models are found. Coping with these issues, we introduce the concept of synchronized object life cycles and we define a mapping of data constraints of a process model to Petri nets extending an existing mapping. Further, we apply the notion of weak conformance to process models to tell whether each time an activity needs to access a data object in a particular state, it is guaranteed that the data object is in or can reach the expected state. Then, we introduce an algorithm for an integrated verification of control flow correctness and weak data conformance using soundness checking.}, language = {en} } @book{PufahlMeyerWeske2013, author = {Pufahl, Luise and Meyer, Andreas and Weske, Mathias}, title = {Batch regions : process instance synchronization based on data}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-280-3}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-69081}, publisher = {Universit{\"a}t Potsdam}, pages = {18}, year = {2013}, abstract = {Business process automation improves organizations' efficiency to perform work. In existing business process management systems, process instances run independently from each other. However, synchronizing instances carrying similar characteristics, i.e., sharing the same data, can reduce process execution costs. For example, if an online retailer receives two orders from one customer, there is a chance that they can be packed and shipped together to save shipment costs. In this paper, we use concepts from the database domain and introduce data views to business processes to identify instances which can be synchronized. Based on data views, we introduce the concept of batch regions for a context-aware instance synchronization over a set of connected activities. We also evaluate the concepts introduced in this paper with a case study comparing costs for normal and batch processing.}, language = {de} } @article{WannickeFrindteGustetal.2015, author = {Wannicke, Nicola and Frindte, Katharina and Gust, Giselher and Liskow, Iris and Wacker, Alexander and Meyer, Andreas and Grossart, Hans-Peter}, title = {Measuring bacterial activity and community composition at high hydrostatic pressure using a novel experimental approach: a pilot study}, series = {FEMS microbiology ecology}, volume = {91}, journal = {FEMS microbiology ecology}, number = {5}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0168-6496}, doi = {10.1093/femsec/fiv036}, pages = {15}, year = {2015}, abstract = {In this pilot study, we describe a high-pressure incubation system allowing multiple subsampling of a pressurized culture without decompression. The system was tested using one piezophilic (Photobacterium profundum), one piezotolerant (Colwellia maris) bacterial strain and a decompressed sample from the Mediterranean deep sea (3044 m) determining bacterial community composition, protein production (BPP) and cell multiplication rates (BCM) up to 27 MPa. The results showed elevation of BPP at high pressure was by a factor of 1.5 +/- 1.4 and 3.9 +/- 2.3 for P. profundum and C. maris, respectively, compared to ambient-pressure treatments and by a factor of 6.9 +/- 3.8 fold in the field samples. In P. profundum and C. maris, BCM at high pressure was elevated (3.1 +/- 1.5 and 2.9 +/- 1.7 fold, respectively) compared to the ambient-pressure treatments. After 3 days of incubation at 27 MPa, the natural bacterial deep-sea community was dominated by one phylum of the genus Exiguobacterium, indicating the rapid selection of piezotolerant bacteria. In future studies, our novel incubation system could be part of an isopiestic pressure chain, allowing more accurate measurement of bacterial activity rates which is important both for modeling and for predicting the efficiency of the oceanic carbon pump.}, language = {en} } @article{deVeraBoettgerdelaTorreNoetzeletal.2012, author = {de Vera, Jean-Pierre Paul and B{\"o}ttger, Ute and de la Torre N{\"o}tzel, Rosa and Sanchez, Francisco J. and Grunow, Dana and Schmitz, Nicole and Lange, Caroline and H{\"u}bers, Heinz-Wilhelm and Billi, Daniela and Baque, Mickael and Rettberg, Petra and Rabbow, Elke and Reitz, G{\"u}nther and Berger, Thomas and M{\"o}ller, Ralf and Bohmeier, Maria and Horneck, Gerda and Westall, Frances and J{\"a}nchen, Jochen and Fritz, J{\"o}rg and Meyer, Cornelia and Onofri, Silvano and Selbmann, Laura and Zucconi, Laura and Kozyrovska, Natalia and Leya, Thomas and Foing, Bernard and Demets, Rene and Cockell, Charles S. and Bryce, Casey and Wagner, Dirk and Serrano, Paloma and Edwards, Howell G. M. and Joshi, Jasmin Radha and Huwe, Bj{\"o}rn and Ehrenfreund, Pascale and Elsaesser, Andreas and Ott, Sieglinde and Meessen, Joachim and Feyh, Nina and Szewzyk, Ulrich and Jaumann, Ralf and Spohn, Tilman}, title = {Supporting Mars exploration BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology}, series = {Planetary and space science}, volume = {74}, journal = {Planetary and space science}, number = {1}, publisher = {Elsevier}, address = {Oxford}, issn = {0032-0633}, doi = {10.1016/j.pss.2012.06.010}, pages = {103 -- 110}, year = {2012}, abstract = {The Low Earth Orbit (LEO) experiment Biology and Mars Experiment (BIOMEX) is an interdisciplinary and international space research project selected by ESA. The experiment will be accommodated on the space exposure facility EXPOSE-R2 on the International Space Station (ISS) and is foreseen to be launched in 2013. The prime objective of BIOMEX is to measure to what extent biomolecules, such as pigments and cellular components, are resistant to and able to maintain their stability under space and Mars-like conditions. The results of BIOMEX will be relevant for space proven biosignature definition and for building a biosignature data base (e.g. the proposed creation of an international Raman library). The library will be highly relevant for future space missions such as the search for life on Mars. The secondary scientific objective is to analyze to what extent terrestrial extremophiles are able to survive in space and to determine which interactions between biological samples and selected minerals (including terrestrial, Moon- and Mars analogs) can be observed under space and Mars-like conditions. In this context, the Moon will be an additional platform for performing similar experiments with negligible magnetic shielding and higher solar and galactic irradiation compared to LEO. Using the Moon as an additional astrobiological exposure platform to complement ongoing astrobiological LEO investigations could thus enhance the chances of detecting organic traces of life on Mars. We present a lunar lander mission with two related objectives: a lunar lander equipped with Raman and PanCam instruments which can analyze the lunar surface and survey an astrobiological exposure platform. This dual use of testing mission technology together with geo- and astrobiological analyses will significantly increase the science return, and support the human preparation objectives. It will provide knowledge about the Moon's surface itself and, in addition, monitor the stability of life-markers, such as cells, cell components and pigments, in an extraterrestrial environment with much closer radiation properties to the surface of Mars. The combination of a Raman data base of these data together with data from LEO and space simulation experiments, will lead to further progress on the analysis and interpretation of data that we will obtain from future Moon and Mars exploration missions.}, language = {en} } @article{JeltschBlaumBroseetal.2013, author = {Jeltsch, Florian and Blaum, Niels and Brose, Ulrich and Chipperfield, Joseph D. and Clough, Yann and Farwig, Nina and Geissler, Katja and Graham, Catherine H. and Grimm, Volker and Hickler, Thomas and Huth, Andreas and May, Felix and Meyer, Katrin M. and Pagel, J{\"o}rn and Reineking, Bj{\"o}rn and Rillig, Matthias C. and Shea, Katriona and Schurr, Frank Martin and Schroeder, Boris and Tielb{\"o}rger, Katja and Weiss, Lina and Wiegand, Kerstin and Wiegand, Thorsten and Wirth, Christian and Zurell, Damaris}, title = {How can we bring together empiricists and modellers in functional biodiversity research?}, series = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie}, volume = {14}, journal = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie}, number = {2}, publisher = {Elsevier}, address = {Jena}, issn = {1439-1791}, doi = {10.1016/j.baae.2013.01.001}, pages = {93 -- 101}, year = {2013}, abstract = {Improving our understanding of biodiversity and ecosystem functioning and our capacity to inform ecosystem management requires an integrated framework for functional biodiversity research (FBR). However, adequate integration among empirical approaches (monitoring and experimental) and modelling has rarely been achieved in FBR. We offer an appraisal of the issues involved and chart a course towards enhanced integration. A major element of this path is the joint orientation towards the continuous refinement of a theoretical framework for FBR that links theory testing and generalization with applied research oriented towards the conservation of biodiversity and ecosystem functioning. We further emphasize existing decision-making frameworks as suitable instruments to practically merge these different aims of FBR and bring them into application. This integrated framework requires joint research planning, and should improve communication and stimulate collaboration between modellers and empiricists, thereby overcoming existing reservations and prejudices. The implementation of this integrative research agenda for FBR requires an adaptation in most national and international funding schemes in order to accommodate such joint teams and their more complex structures and data needs.}, language = {en} } @misc{NeumannHorstkemperKruegeretal.2002, author = {Neumann, Bernhard and Horstkemper, Marianne and Kr{\"u}ger, Wolfgang and Wilkens, Martin and Bohlen, Andreas and Fr{\"u}bing, Peter and Wegener, Michael and Scheff, Ullrich and Neher, Dieter and Brehmer, Ludwig and Kleinpeter, Erich and Wolf, Gunter and Koetz, Joachim and Peter, Martin G. and Senkbeil, Sigrid and Meyer, Till}, title = {Portal = Im Trend: Physiker und Chemiker erforschen "Soft Matter"}, volume = {2002}, issn = {1618-6893}, doi = {10.25932/publishup-50144}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-501441}, pages = {40}, year = {2002}, abstract = {Aus dem Inhalt: Im Trend: Physiker und Chemiker erforschen „Soft Matter" -Brandenburger Netzwerk f{\"u}r Existenzgr{\"u}nder erh{\"a}lt F{\"o}rderung -Universit{\"a}t leistet Beitrag zum Romantik-Jahr -Musiksender MTV und Bryan Adams auf dem Campus}, language = {de} }