@article{TaalStPourcainThieringetal.2012,
  author    = {Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Moller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Monica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bonnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Mueller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Breteler, Monique M. B. and Debette, Stephanie and Fornage, Myriam and Gudnason, Vilmundur and Launer, Lenore J. and van der Lugt, Aad and Mosley, Thomas H. and Seshadri, Sudha and Smith, Albert V. and Vernooij, Meike W. and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Grant, Struan F. A. and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iniguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Molgaard, Anne and Newnham, John P. and Palmer, Lyle J. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Standl, Marie and Uitterlinden, Andre G. and Wichmann, H-Erich and Vissing, Nadja Hawwa and DeCarli, Charles and van Duijn, Cornelia M. and McCarthy, Mark I. and Koppelman, Gerard H. and Estivill, Xavier and Hattersley, Andrew T. and Melbye, Mads and Bisgaard, Hans and Pennell, Craig E. and Widen, Elisabeth and Hakonarson, Hakon and Smith, George Davey and Heinrich, Joachim and Jarvelin, Marjo-Riitta and Jaddoe, Vincent W. V. and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane J. and Bradfield, Jonathan P. and Charoen, Pimphen and Coin, Lachlan and Cousminer, Diana L. and Das, Shikta and Davis, Oliver S. P. and Elliott, Paul and Evans, David M. and Feenstra, Bjarke and Flexeder, Claudia and Frayling, Tim and Freathy, Rachel M. and Gaillard, Romy and Geller, Frank and Groen-Blokhuis, Maria and Goh, Liang-Kee and Guxens, Monica and Haworth, Claire M. A. and Hadley, Dexter and Hebebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Hottenga, Jouke Jan and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Iniguez, Carmen and Kaakinen, Marika and Kilpelainen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimaki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Mook-Kanamori, Dennis O. and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and O'Reilly, Paul F. and Palmer, Lyle J. and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Prokopenko, Inga and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Sovio, Ulla and St Pourcain, Beate and Strachan, David P. and Sunyer, Jordi and Taal, H. Rob and Teo, Yik-Ying and Thiering, Elisabeth and Tiesler, Carla and Uitterlinden, Andre G. and Valcarcel, Beatriz and Warrington, Nicole M. and White, Scott and Willemsen, Gonneke and Yaghootkar, Hanieh and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Hocher, Berthold and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and Lakka, Timo A. and McCarthy, Mark I. and Melbye, Mads and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Pennell, Craig E. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sorensen, Thorkild I. A. and Timpson, Nicholas J. and Widen, Elisabeth and Wilson, James F. and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane J. and Bradfield, Jonathan P. and Charoen, Pimphen and Coin, Lachlan and Cousminer, Diana L. and Das, Shikta and Elliott, Paul and Evans, David M. and Frayling, Tim and Freathy, Rachel M. and Gaillard, Romy and Groen-Blokhuis, Maria and Guxens, Monica and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kaakinen, Marika and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Mook-Kanamori, Dennis O. and Nivard, Michel and O'Reilly, Paul F. and Palmer, Lyle J. and Prokopenko, Inga and Rodriguez, Alina and Sebert, Sylvain and Sovio, Ulla and St Pourcain, Beate and Standl, Marie and Strachan, David P. and Sunyer, Jordi and Taal, H. Rob and Thiering, Elisabeth and Tiesler, Carla and Uitterlinden, Andre G. and Valcarcel, Beatriz and Warrington, Nicole M. and White, Scott and Willemsen, Gonneke and Yaghootkar, Hanieh and Boomsma, Dorret I. and Estivill, Xavier and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Timpson, Nicholas J. and Widen, Elisabeth and Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stephanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles},
  title     = {Common variants at 12q15 and 12q24 are associated with infant head circumference},
  series = {Nature genetics},
  volume    = {44},
  journal   = {Nature genetics},
  number    = {5},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {Cohorts Heart Aging Res Genetic Ep, Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti},
  issn      = {1061-4036},
  doi       = {10.1038/ng.2238},
  pages     = {532 -- +},
  year      = {2012},
  abstract  = {To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.},
  language  = {en}
}
@article{IkramFornageSmithetal.2012,
  author    = {Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stephanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Taal, H. Rob and Mook-Kanamori, Dennis O. and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Knopman, David S. and Hartikainen, Anna-Liisa and Pennell, Craig E. and Thiering, Elisabeth and Steegers, Eric A. P. and Hakonarson, Hakon and Heinrich, Joachim and Palmer, Lyle J. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Grant, Struan F. A. and St Pourcain, Beate and Timpson, Nicholas J. and Smith, George Davey and Sovio, Ulla and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Jaddoe, Vincent W. V. and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and vanBeijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane J. and Coin, Lachlan and Davis, Oliver S. P. and Elliott, Paul and Flexeder, Claudia and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Goh, Liang-Kee and Haworth, Claire M. A. and Hadley, Dexter and Hebebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Hottenga, Jouke Jan and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Kilpelainen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimaki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Strachan, David P. and Teo, Yik-Ying and Valcarcel, Beatriz and Willemsen, Gonneke and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Gillman, Matthew and Hocher, Berthold and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sorensen, Thorkild I. A. and Wilson, James F.},
  title     = {Common variants at 6q22 and 17q21 are associated with intracranial volume},
  series = {Nature genetics},
  volume    = {44},
  journal   = {Nature genetics},
  number    = {5},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep},
  issn      = {1061-4036},
  doi       = {10.1038/ng.2245},
  pages     = {539 -- +},
  year      = {2012},
  abstract  = {During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.},
  language  = {en}
}
@article{WuttkeLiLietal.2019,
  author    = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian},
  title     = {A catalog of genetic loci associated with kidney function from analyses of a million individuals},
  series = {Nature genetics},
  volume    = {51},
  journal   = {Nature genetics},
  number    = {6},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {Lifelines COHort Study},
  issn      = {1061-4036},
  doi       = {10.1038/s41588-019-0407-x},
  pages     = {957 -- +},
  year      = {2019},
  abstract  = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.},
  language  = {en}
}
@article{MartinezGonzalezPastorYabarLaggetal.2016,
  author    = {Martinez Gonzalez, M. J. and Pastor Yabar, A. and Lagg, A. and Asensio Ramos, A. and Collados Vera, M. and Solanki, S. K. and Balthasar, H. and Berkefeld, T. and Denker, Carsten and Doerr, H. P. and Feller, A. and Franz, M. and Gonz{\´a}lez Manrique, Sergio Javier and Hofmann, A. and Kneer, F. and Kuckein, Christoph and Louis, R. and von der L{\"u}he, O. and Nicklas, H. and Orozco, D. and Rezaei, R. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Verma, Meetu and Waldman, T. and Volkmer, R.},
  title     = {Inference of magnetic fields in the very quiet Sun},
  series = {Journal of geophysical research : Earth surface},
  volume    = {596},
  journal   = {Journal of geophysical research : Earth surface},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  issn      = {1432-0746},
  doi       = {10.1051/0004-6361/201628449},
  pages     = {11},
  year      = {2016},
  abstract  = {Context. Over the past 20 yr, the quietest areas of the solar surface have revealed a weak but extremely dynamic magnetism occurring at small scales (<500 km), which may provide an important contribution to the dynamics and energetics of the outer layers of the atmosphere. Understanding this magnetism requires the inference of physical quantities from high-sensitivity spectro-polarimetric data with high spatio-temporal resolution. Aims. We present high-precision spectro-polarimetric data with high spatial resolution (0.4") of the very quiet Sun at 1.56 mu m obtained with the GREGOR telescope to shed some light on this complex magnetism. Methods. We used inversion techniques in two main approaches. First, we assumed that the observed profiles can be reproduced with a constant magnetic field atmosphere embedded in a field-free medium. Second, we assumed that the resolution element has a substructure with either two constant magnetic atmospheres or a single magnetic atmosphere with gradients of the physical quantities along the optical depth, both coexisting with a global stray-light component. Results. Half of our observed quiet-Sun region is better explained by magnetic substructure within the resolution element. However, we cannot distinguish whether this substructure comes from gradients of the physical parameters along the line of sight or from horizontal gradients (across the surface). In these pixels, a model with two magnetic components is preferred, and we find two distinct magnetic field populations. The population with the larger filling factor has very weak (similar to 150 G) horizontal fields similar to those obtained in previous works. We demonstrate that the field vector of this population is not constrained by the observations, given the spatial resolution and polarimetric accuracy of our data. The topology of the other component with the smaller filling factor is constrained by the observations for field strengths above 250 G: we infer hG fields with inclinations and azimuth values compatible with an isotropic distribution. The filling factors are typically below 30\%. We also find that the flux of the two polarities is not balanced. From the other half of the observed quiet-Sun area similar to 50\% are two-lobed Stokes V profiles, meaning that 23\% of the field of view can be adequately explained with a single constant magnetic field embedded in a non-magnetic atmosphere. The magnetic field vector and filling factor are reliable inferred in only 50\% based on the regular profiles. Therefore, 12\% of the field of view harbour hG fields with filling factors typically below 30\%. At our present spatial resolution, 70\% of the pixels apparently are non-magnetised.},
  language  = {en}
}
@article{BalthasarGoemoeryGonzalezManriqueetal.2016,
  author    = {Balthasar, H. and G{\"o}m{\"o}ry, P. and Gonz{\´a}lez Manrique, Sergio Javier and Kuckein, Christoph and Kavka, J. and Kucera, A. and Schwartz, P. and Vaskova, R. and Berkefeld, T. and Collados Vera, M. and Denker, Carsten and Feller, A. and Hofmann, A. and Lagg, A. and Nicklas, H. and Suarez, D. and Pastor Yabar, A. and Rezaei, R. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.},
  title     = {Spectropolarimetric observations of an arch filament system with the GREGOR solar telescope},
  series = {Astronomische Nachrichten = Astronomical notes},
  volume    = {337},
  journal   = {Astronomische Nachrichten = Astronomical notes},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0004-6337},
  doi       = {10.1002/asna.201612432},
  pages     = {1050 -- 1056},
  year      = {2016},
  abstract  = {Arch filament systems occur in active sunspot groups, where a fibril structure connects areas of opposite magnetic polarity, in contrast to active region filaments that follow the polarity inversion line. We used the GREGOR Infrared Spectrograph (GRIS) to obtain the full Stokes vector in the spectral lines SiI lambda 1082.7 nm, He I lambda 1083.0 nm, and Ca I lambda 1083.9 nm. We focus on the near-infrared calcium line to investigate the photospheric magnetic field and velocities, and use the line core intensities and velocities of the helium line to study the chromospheric plasma. The individual fibrils of the arch filament system connect the sunspot with patches of magnetic polarity opposite to that of the spot. These patches do not necessarily coincide with pores, where the magnetic field is strongest. Instead, areas are preferred not far from the polarity inversion line. These areas exhibit photospheric downflows of moderate velocity, but significantly higher downflows of up to 30 km s(-1) in the chromospheric helium line. Our findings can be explained with new emerging flux where the matter flows downward along the field lines of rising flux tubes, in agreement with earlier results. (C) 2016 WILEY-VCH Verlag GmbH\& Co. KGaA, Weinheim},
  language  = {en}
}
@article{VermaDenkerBalthasaretal.2016,
  author    = {Verma, Meetu and Denker, Carsten and Balthasar, H. and Kuckein, Christoph and Gonz{\´a}lez Manrique, Sergio Javier and Sobotka, M. and Gonzalez, N. Bello and Hoch, S. and Diercke, Andrea and Kummerow, Philipp and Berkefeld, T. and Collados Vera, M. and Feller, A. and Hofmann, A. and Kneer, F. and Lagg, A. and L{\"o}hner-B{\"o}ttcher, J. and Nicklas, H. and Pastor Yabar, A. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Schubert, M. and Sigwarth, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.},
  title     = {Horizontal flow fields in and around a small active region The transition period between flux emergence and decay},
  series = {Polymers},
  volume    = {596},
  journal   = {Polymers},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  issn      = {1432-0746},
  doi       = {10.1051/0004-6361/201628380},
  pages     = {12},
  year      = {2016},
  abstract  = {Context. The solar magnetic field is responsible for all aspects of solar activity. Thus, emergence of magnetic flux at the surface is the first manifestation of the ensuing solar activity. Aims. Combining high-resolution and synoptic observations aims to provide a comprehensive description of flux emergence at photospheric level and of the growth process that eventually leads to a mature active region. Methods. The small active region NOAA 12118 emerged on 2014 July 17 and was observed one day later with the 1.5-m GREGOR solar telescope on 2014 July 18. High-resolution time-series of blue continuum and G-band images acquired in the blue imaging channel (BIC) of the GREGOR Fabry-Perot Interferometer (GFPI) were complemented by synoptic line-of-sight magnetograms and continuum images obtained with the Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO). Horizontal proper motions and horizontal plasma velocities were computed with local correlation tracking (LCT) and the differential affine velocity estimator (DAVE), respectively. Morphological image processing was employed to measure the photometric and magnetic area, magnetic flux, and the separation profile of the emerging flux region during its evolution. Results. The computed growth rates for photometric area, magnetic area, and magnetic flux are about twice as high as the respective decay rates. The space-time diagram using HMI magnetograms of five days provides a comprehensive view of growth and decay. It traces a leaf-like structure, which is determined by the initial separation of the two polarities, a rapid expansion phase, a time when the spread stalls, and a period when the region slowly shrinks again. The separation rate of 0.26 km s(-1) is highest in the initial stage, and it decreases when the separation comes to a halt. Horizontal plasma velocities computed at four evolutionary stages indicate a changing pattern of inflows. In LCT maps we find persistent flow patterns such as outward motions in the outer part of the two major pores, a diverging feature near the trailing pore marking the site of upwelling plasma and flux emergence, and low velocities in the interior of dark pores. We detected many elongated rapidly expanding granules between the two major polarities, with dimensions twice as large as the normal granules.},
  language  = {en}
}
@article{GonzalezManriqueKuckeinPastorYabaretal.2016,
  author    = {Gonzalez Manrique, Sergio Javier and Kuckein, Christoph and Pastor Yabar, A. and Collados Vera, M. and Denker, Carsten and Fischer, C. E. and G{\"o}m{\"o}ry, P. and Diercke, Andrea and Gonzalez, N. Bello and Schlichenmaier, R. and Balthasar, H. and Berkefeld, T. and Feller, A. and Hoch, S. and Hofmann, A. and Kneer, F. and Lagg, A. and Nicklas, H. and Orozco Suarez, D. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Verma, Meetu and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.},
  title     = {Fitting peculiar spectral profiles in He I 10830 angstrom absorption features},
  series = {Astronomische Nachrichten = Astronomical notes},
  volume    = {337},
  journal   = {Astronomische Nachrichten = Astronomical notes},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0004-6337},
  doi       = {10.1002/asna.201512433},
  pages     = {1057 -- 1063},
  year      = {2016},
  abstract  = {The new generation of solar instruments provides better spectral, spatial, and temporal resolution for a better understanding of the physical processes that take place on the Sun. Multiple-component profiles are more commonly observed with these instruments. Particularly, the He i 10830 triplet presents such peculiar spectral profiles, which give information on the velocity and magnetic fine structure of the upper chromosphere. The purpose of this investigation is to describe a technique to efficiently fit the two blended components of the He i 10830 triplet, which are commonly observed when two atmospheric components are located within the same resolution element. The observations used in this study were taken on 2015 April 17 with the very fast spectroscopic mode of the GREGOR Infrared Spectrograph (GRIS) attached to the 1.5-m GREGOR solar telescope, located at the Observatorio del Teide, Tenerife, Spain. We apply a double-Lorentzian fitting technique using Levenberg-Marquardt least-squares minimization. This technique is very simple and much faster than inversion codes. Line-of-sight Doppler velocities can be inferred for a whole map of pixels within just a few minutes. Our results show sub-and supersonic downflow velocities of up to 32 km s(-1) for the fast component in the vicinity of footpoints of filamentary structures. The slow component presents velocities close to rest. (C) 2016 WILEY-VCH Verlag GmbH\& Co. KGaA, Weinheim},
  language  = {en}
}
@article{VermaDenkerBoehmetal.2016,
  author    = {Verma, Meetu and Denker, Carsten and B{\"o}hm, F. and Balthasar, H. and Fischer, C. E. and Kuckein, Christoph and Gonzalez, N. Bello and Berkefeld, T. and Collados Vera, M. and Diercke, Andrea and Feller, A. and Gonzalez Manrique, Sergio Javier and Hofmann, A. and Lagg, A. and Nicklas, H. and Orozco Suarez, D. and Pator Yabar, A. and Rezaei, R. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.},
  title     = {Flow and magnetic field properties in the trailing sunspots of active region NOAA 12396},
  series = {Astronomische Nachrichten = Astronomical notes},
  volume    = {337},
  journal   = {Astronomische Nachrichten = Astronomical notes},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0004-6337},
  doi       = {10.1002/asna.201612447},
  pages     = {1090 -- 1098},
  year      = {2016},
  abstract  = {Improved measurements of the photospheric and chromospheric three-dimensional magnetic and flow fields are crucial for a precise determination of the origin and evolution of active regions. We present an illustrative sample of multi-instrument data acquired during a two-week coordinated observing campaign in August 2015 involving, among others, the GREGOR solar telescope (imaging and near-infrared spectroscopy) and the space missions Solar Dynamics Observatory (SDO) and Interface Region Imaging Spectrograph (IRIS). The observations focused on the trailing part of active region NOAA 12396 with complex polarity inversion lines and strong intrusions of opposite polarity flux. The GREGOR Infrared Spectrograph (GRIS) provided Stokes IQUV spectral profiles in the photospheric Si i.1082.7 nm line, the chromospheric He I lambda 1083.0 nm triplet, and the photospheric Ca I lambda 1083.9 nm line. Carefully calibrated GRIS scans of the active region provided maps of Doppler velocity and magnetic field at different atmospheric heights. We compare quick-look maps with those obtained with the " Stokes Inversions based on Response functions" (SIR) code, which furnishes deeper insight into the magnetic properties of the region. We find supporting evidence that newly emerging flux and intruding opposite polarity flux are hampering the formation of penumbrae, i.e., a penumbra fully surrounding a sunspot is only expected after cessation of flux emergence in proximity to the sunspots. (C) 2016 WILEY-VCH Verlag GmbH\& Co.KGaA, Weinheim},
  language  = {en}
}
@misc{GorskiJungLietal.2020,
  author    = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.},
  title     = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t},
  number    = {19},
  doi       = {10.25932/publishup-56537},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565379},
  pages     = {14},
  year      = {2020},
  abstract  = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.},
  language  = {en}
}
@article{GorskiJungLietal.2020,
  author    = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.},
  title     = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline},
  series = {Kidney international : official journal of the International Society of Nephrology},
  volume    = {99},
  journal   = {Kidney international : official journal of the International Society of Nephrology},
  number    = {4},
  publisher = {Elsevier},
  address   = {New York},
  organization    = {Lifelines Cohort Study<br /> Regeneron Genetics Ctr},
  issn      = {0085-2538},
  doi       = {10.1016/j.kint.2020.09.030},
  pages     = {926 -- 939},
  year      = {2020},
  abstract  = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.},
  language  = {en}
}
@book{ZhangPlauthEberhardtetal.2020,
  author    = {Zhang, Shuhao and Plauth, Max and Eberhardt, Felix and Polze, Andreas and Lehmann, Jens and Sejdiu, Gezim and Jabeen, Hajira and Servadei, Lorenzo and M{\"o}stl, Christian and B{\"a}r, Florian and Netzeband, Andr{\´e} and Schmidt, Rainer and Knigge, Marlene and Hecht, Sonja and Prifti, Loina and Krcmar, Helmut and Sapegin, Andrey and Jaeger, David and Cheng, Feng and Meinel, Christoph and Friedrich, Tobias and Rothenberger, Ralf and Sutton, Andrew M. and Sidorova, Julia A. and Lundberg, Lars and Rosander, Oliver and Sk{\"o}ld, Lars and Di Varano, Igor and van der Walt, Est{\´e}e and Eloff, Jan H. P. and Fabian, Benjamin and Baumann, Annika and Ermakova, Tatiana and Kelkel, Stefan and Choudhary, Yash and Cooray, Thilini and Rodr{\´i}guez, Jorge and Medina-P{\´e}rez, Miguel Angel and Trejo, Luis A. and Barrera-Animas, Ari Yair and Monroy-Borja, Ra{\´u}l and L{\´o}pez-Cuevas, Armando and Ram{\´i}rez-M{\´a}rquez, Jos{\´e} Emmanuel and Grohmann, Maria and Niederleithinger, Ernst and Podapati, Sasidhar and Schmidt, Christopher and Huegle, Johannes and de Oliveira, Roberto C. L. and Soares, F{\´a}bio Mendes and van Hoorn, Andr{\´e} and Neumer, Tamas and Willnecker, Felix and Wilhelm, Mathias and Kuster, Bernhard},
  title     = {HPI Future SOC Lab - Proceedings 2017},
  number    = {130},
  editor    = {Meinel, Christoph and Polze, Andreas and Beins, Karsten and Strotmann, Rolf and Seibold, Ulrich and R{\"o}dszus, Kurt and M{\"u}ller, J{\"u}rgen},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-475-3},
  issn      = {1613-5652},
  doi       = {10.25932/publishup-43310},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-433100},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {ix, 235},
  year      = {2020},
  abstract  = {The "HPI Future SOC Lab" is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2017. Selected projects have presented their results on April 25th and November 15th 2017 at the Future SOC Lab Day events.},
  language  = {en}
}
@unpublished{AcharyaActisAghajanietal.2013,
  author    = {Acharya, B. S. and Actis, M. and Aghajani, T. and Agnetta, G. and Aguilar, J. and Aharonian, Felix A. and Ajello, M. and Akhperjanian, A. G. and Alcubierre, M. and Aleksic, J. and Alfaro, R. and Aliu, E. and Allafort, A. J. and Allan, D. and Allekotte, I. and Amato, E. and Anderson, J. and Ang{\"u}ner, Ekrem Oǧuzhan and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Armstrong, T. and Arnaldi, H. and Arrabito, L. and Asano, K. and Ashton, T. and Asorey, H. G. and Awane, Y. and Baba, H. and Babic, A. and Baby, N. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balbo, M. and Balis, D. and Balkowski, C. and Bamba, A. and Bandiera, R. and Barber, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and Barres de Almeida, U. and Barrio, J. A. and Basili, A. and Basso, S. and Bastieri, D. and Bauer, C. and Baushev, Anton N. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Tjus, J. Becker and Beckmann, Volker and Bednarek, W. and Behera, B. and Belluso, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernard, F. and Bernardino, T. and Bernl{\"o}hr, K. and Bhat, N. and Bhattacharyya, S. and Bigongiari, C. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Biteau, Jonathan and Bitossi, M. and Blake, S. and Blanch Bigas, O. and Blasi, P. and Bobkov, A. A. and Boccone, V. and Boettcher, Markus and Bogacz, L. and Bogart, J. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Bonifacio, P. and Bonnoli, G. and Bordas, Pol and Borgland, A. W. and Borkowski, Janett and Bose, R. and Botner, O. and Bottani, A. and Bouchet, L. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Bringmann, T. and Brook, P. and Brun, Pierre and Brunetti, L. and Buanes, T. and Buckley, J. 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  title     = {Introducing the CTA concept},
  series = {Astroparticle physics},
  volume    = {43},
  journal   = {Astroparticle physics},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  organization    = {CTA Consortium},
  issn      = {0927-6505},
  doi       = {10.1016/j.astropartphys.2013.01.007},
  pages     = {3 -- 18},
  year      = {2013},
  abstract  = {The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.},
  language  = {en}
}
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  title     = {Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy},
  series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis},
  volume    = {32},
  journal   = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis},
  number    = {3},
  publisher = {Springer},
  address   = {Dordrecht},
  organization    = {CTA Consortium},
  issn      = {0922-6435},
  doi       = {10.1007/s10686-011-9247-0},
  pages     = {193 -- 316},
  year      = {2011},
  abstract  = {Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.},
  language  = {en}
}
@article{AartsAndersonAndersonetal.2015,
  author    = {Aarts, Alexander A. and Anderson, Joanna E. and Anderson, Christopher J. and Attridge, Peter R. and Attwood, Angela and Axt, Jordan and Babel, Molly and Bahnik, Stepan and Baranski, Erica and Barnett-Cowan, Michael and Bartmess, Elizabeth and Beer, Jennifer and Bell, Raoul and Bentley, Heather and Beyan, Leah and Binion, Grace and Borsboom, Denny and Bosch, Annick and Bosco, Frank A. and Bowman, Sara D. and Brandt, Mark J. and Braswell, Erin and Brohmer, Hilmar and Brown, Benjamin T. and Brown, Kristina and Bruening, Jovita and Calhoun-Sauls, Ann and Callahan, Shannon P. and Chagnon, Elizabeth and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cillessen, Linda and Clay, Russ and Cleary, Hayley and Cloud, Mark D. and Cohn, Michael and Cohoon, Johanna and Columbus, Simon and Cordes, Andreas and Costantini, Giulio and Alvarez, Leslie D. Cramblet and Cremata, Ed and Crusius, Jan and DeCoster, Jamie and DeGaetano, Michelle A. and Della Penna, Nicolas and den Bezemer, Bobby and Deserno, Marie K. and Devitt, Olivia and Dewitte, Laura and Dobolyi, David G. and Dodson, Geneva T. and Donnellan, M. Brent and Donohue, Ryan and Dore, Rebecca A. and Dorrough, Angela and Dreber, Anna and Dugas, Michelle and Dunn, Elizabeth W. and Easey, Kayleigh and Eboigbe, Sylvia and Eggleston, Casey and Embley, Jo and Epskamp, Sacha and Errington, Timothy M. and Estel, Vivien and Farach, Frank J. and Feather, Jenelle and Fedor, Anna and Fernandez-Castilla, Belen and Fiedler, Susann and Field, James G. and Fitneva, Stanka A. and Flagan, Taru and Forest, Amanda L. and Forsell, Eskil and Foster, Joshua D. and Frank, Michael C. and Frazier, Rebecca S. and Fuchs, Heather and Gable, Philip and Galak, Jeff and Galliani, Elisa Maria and Gampa, Anup and Garcia, Sara and Gazarian, Douglas and Gilbert, Elizabeth and Giner-Sorolla, Roger and Gl{\"o}ckner, Andreas and G{\"o}llner, Lars and Goh, Jin X. and Goldberg, Rebecca and Goodbourn, Patrick T. and Gordon-McKeon, Shauna and Gorges, Bryan and Gorges, Jessie and Goss, Justin and Graham, Jesse and Grange, James A. and Gray, Jeremy and Hartgerink, Chris and Hartshorne, Joshua and Hasselman, Fred and Hayes, Timothy and Heikensten, Emma and Henninger, Felix and Hodsoll, John and Holubar, Taylor and Hoogendoorn, Gea and Humphries, Denise J. and Hung, Cathy O. -Y. and Immelman, Nathali and Irsik, Vanessa C. and Jahn, Georg and Jaekel, Frank and Jekel, Marc and Johannesson, Magnus and Johnson, Larissa G. and Johnson, David J. and Johnson, Kate M. and Johnston, William J. and Jonas, Kai and Joy-Gaba, Jennifer A. and Kappes, Heather Barry and Kelso, Kim and Kidwell, Mallory C. and Kim, Seung Kyung and Kirkhart, Matthew and Kleinberg, Bennett and Knezevic, Goran and Kolorz, Franziska Maria and Kossakowski, Jolanda J. and Krause, Robert Wilhelm and Krijnen, Job and Kuhlmann, Tim and Kunkels, Yoram K. and Kyc, Megan M. and Lai, Calvin K. and Laique, Aamir and Lakens, Daniel and Lane, Kristin A. and Lassetter, Bethany and Lazarevic, Ljiljana B. and LeBel, Etienne P. and Lee, Key Jung and Lee, Minha and Lemm, Kristi and Levitan, Carmel A. and Lewis, Melissa and Lin, Lin and Lin, Stephanie and Lippold, Matthias and Loureiro, Darren and Luteijn, Ilse and Mackinnon, Sean and Mainard, Heather N. and Marigold, Denise C. and Martin, Daniel P. and Martinez, Tylar and Masicampo, E. J. and Matacotta, Josh and Mathur, Maya and May, Michael and Mechin, Nicole and Mehta, Pranjal and Meixner, Johannes and Melinger, Alissa and Miller, Jeremy K. and Miller, Mallorie and Moore, Katherine and M{\"o}schl, Marcus and Motyl, Matt and M{\"u}ller, Stephanie M. and Munafo, Marcus and Neijenhuijs, Koen I. and Nervi, Taylor and Nicolas, Gandalf and Nilsonne, Gustav and Nosek, Brian A. and Nuijten, Michele B. and Olsson, Catherine and Osborne, Colleen and Ostkamp, Lutz and Pavel, Misha and Penton-Voak, Ian S. and Perna, Olivia and Pernet, Cyril and Perugini, Marco and Pipitone, R. Nathan and Pitts, Michael and Plessow, Franziska and Prenoveau, Jason M. and Rahal, Rima-Maria and Ratliff, Kate A. and Reinhard, David and Renkewitz, Frank and Ricker, Ashley A. and Rigney, Anastasia and Rivers, Andrew M. and Roebke, Mark and Rutchick, Abraham M. and Ryan, Robert S. and Sahin, Onur and Saide, Anondah and Sandstrom, Gillian M. and Santos, David and Saxe, Rebecca and Schlegelmilch, Rene and Schmidt, Kathleen and Scholz, Sabine and Seibel, Larissa and Selterman, Dylan Faulkner and Shaki, Samuel and Simpson, William B. and Sinclair, H. Colleen and Skorinko, Jeanine L. M. and Slowik, Agnieszka and Snyder, Joel S. and Soderberg, Courtney and Sonnleitner, Carina and Spencer, Nick and Spies, Jeffrey R. and Steegen, Sara and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and Talhelm, Thomas and Tapia, Megan and te Dorsthorst, Anniek and Thomae, Manuela and Thomas, Sarah L. and Tio, Pia and Traets, Frits and Tsang, Steve and Tuerlinckx, Francis and Turchan, Paul and Valasek, Milan and Van Aert, Robbie and van Assen, Marcel and van Bork, Riet and van de Ven, Mathijs and van den Bergh, Don and van der Hulst, Marije and van Dooren, Roel and van Doorn, Johnny and van Renswoude, Daan R. and van Rijn, Hedderik and Vanpaemel, Wolf and Echeverria, Alejandro Vasquez and Vazquez, Melissa and Velez, Natalia and Vermue, Marieke and Verschoor, Mark and Vianello, Michelangelo and Voracek, Martin and Vuu, Gina and Wagenmakers, Eric-Jan and Weerdmeester, Joanneke and Welsh, Ashlee and Westgate, Erin C. and Wissink, Joeri and Wood, Michael and Woods, Andy and Wright, Emily and Wu, Sining and Zeelenberg, Marcel and Zuni, Kellylynn},
  title     = {Estimating the reproducibility of psychological science},
  series = {Science},
  volume    = {349},
  journal   = {Science},
  number    = {6251},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  organization    = {Open Sci Collaboration},
  issn      = {1095-9203},
  doi       = {10.1126/science.aac4716},
  pages     = {8},
  year      = {2015},
  abstract  = {Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47\% of original effect sizes were in the 95\% confidence interval of the replication effect size; 39\% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68\% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.},
  language  = {en}
}
@article{SramaKruegerYamaguchietal.2012,
  author    = {Srama, Ralf and Krueger, H. and Yamaguchi, T. and Stephan, T. and Burchell, M. and Kearsley, A. T. and Sterken, V. and Postberg, F. and Kempf, S. and Gr{\"u}n, Eberhard and Altobelli, Nicolas and Ehrenfreund, P. and Dikarev, V. and Horanyi, M. and Sternovsky, Zoltan and Carpenter, J. D. and Westphal, A. and Gainsforth, Z. and Krabbe, A. and Agarwal, Jessica and Yano, H. and Blum, J. and Henkel, H. and Hillier, J. and Hoppe, P. and Trieloff, M. and Hsu, S. and Mocker, A. and Fiege, K. and Green, S. F. and Bischoff, A. and Esposito, F. and Laufer, R. and Hyde, T. W. and Herdrich, G. and Fasoulas, S. and Jaeckel, A. and Jones, G. and Jenniskens, P. and Khalisi, E. and Moragas-Klostermeyer, Georg and Spahn, Frank and Keller, H. U. and Frisch, P. and Levasseur-Regourd, A. C. and Pailer, N. and Altwegg, K. and Engrand, C. and Auer, S. and Silen, J. and Sasaki, S. and Kobayashi, M. and Schmidt, J. and Kissel, J. and Marty, B. and Michel, P. and Palumbo, P. and Vaisberg, O. and Baggaley, J. and Rotundi, A. and Roeser, H. P.},
  title     = {SARIM PLUS-sample return of comet 67P/CG and of interstellar matter},
  series = {EXPERIMENTAL ASTRONOMY},
  volume    = {33},
  journal   = {EXPERIMENTAL ASTRONOMY},
  number    = {2-3},
  publisher = {SPRINGER},
  address   = {DORDRECHT},
  issn      = {0922-6435},
  doi       = {10.1007/s10686-011-9285-7},
  pages     = {723 -- 751},
  year      = {2012},
  abstract  = {The Stardust mission returned cometary, interplanetary and (probably) interstellar dust in 2006 to Earth that have been analysed in Earth laboratories worldwide. Results of this mission have changed our view and knowledge on the early solar nebula. The Rosetta mission is on its way to land on comet 67P/Churyumov-Gerasimenko and will investigate for the first time in great detail the comet nucleus and its environment starting in 2014. Additional astronomy and planetary space missions will further contribute to our understanding of dust generation, evolution and destruction in interstellar and interplanetary space and provide constraints on solar system formation and processes that led to the origin of life on Earth. One of these missions, SARIM-PLUS, will provide a unique perspective by measuring interplanetary and interstellar dust with high accuracy and sensitivity in our inner solar system between 1 and 2 AU. SARIM-PLUS employs latest in-situ techniques for a full characterisation of individual micrometeoroids (flux, mass, charge, trajectory, composition()) and collects and returns these samples to Earth for a detailed analysis. The opportunity to visit again the target comet of the Rosetta mission 67P/Churyumov-Gerasimeenternko, and to investigate its dusty environment six years after Rosetta with complementary methods is unique and strongly enhances and supports the scientific exploration of this target and the entire Rosetta mission. Launch opportunities are in 2020 with a backup window starting early 2026. The comet encounter occurs in September 2021 and the reentry takes place in early 2024. An encounter speed of 6 km/s ensures comparable results to the Stardust mission.},
  language  = {en}
}
@misc{AndersonBahnikBarnettCowanetal.2016,
  author    = {Anderson, Christopher J. and Bahnik, Stepan and Barnett-Cowan, Michael and Bosco, Frank A. and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cordes, Andreas and Cremata, Edward J. and Della Penna, Nicolas and Estel, Vivien and Fedor, Anna and Fitneva, Stanka A. and Frank, Michael C. and Grange, James A. and Hartshorne, Joshua K. and Hasselman, Fred and Henninger, Felix and van der Hulst, Marije and Jonas, Kai J. and Lai, Calvin K. and Levitan, Carmel A. and Miller, Jeremy K. and Moore, Katherine S. and Meixner, Johannes M. and Munafo, Marcus R. and Neijenhuijs, Koen I. and Nilsonne, Gustav and Nosek, Brian A. and Plessow, Franziska and Prenoveau, Jason M. and Ricker, Ashley A. and Schmidt, Kathleen and Spies, Jeffrey R. and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and van Aert, Robbie C. M. and van Assen, Marcel A. L. M. and Vanpaemel, Wolf and Vianello, Michelangelo and Voracek, Martin and Zuni, Kellylynn},
  title     = {Response to Comment on "Estimating the reproducibility of psychological science"},
  series = {Science},
  volume    = {351},
  journal   = {Science},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {0036-8075},
  doi       = {10.1126/science.aad9163},
  pages     = {1162 -- 1165},
  year      = {2016},
  abstract  = {Gilbert et al. conclude that evidence from the Open Science Collaboration's Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.},
  language  = {en}
}
@misc{ArnisonBibbBierbaumetal.2013,
  author    = {Arnison, Paul G. and Bibb, Mervyn J. and Bierbaum, Gabriele and Bowers, Albert A. and Bugni, Tim S. and Bulaj, Grzegorz and Camarero, Julio A. and Campopiano, Dominic J. and Challis, Gregory L. and Clardy, Jon and Cotter, Paul D. and Craik, David J. and Dawson, Michael and Dittmann-Th{\"u}nemann, Elke and Donadio, Stefano and Dorrestein, Pieter C. and Entian, Karl-Dieter and Fischbach, Michael A. and Garavelli, John S. and Goeransson, Ulf and Gruber, Christian W. and Haft, Daniel H. and Hemscheidt, Thomas K. and Hertweck, Christian and Hill, Colin and Horswill, Alexander R. and Jaspars, Marcel and Kelly, Wendy L. and Klinman, Judith P. and Kuipers, Oscar P. and Link, A. James and Liu, Wen and Marahiel, Mohamed A. and Mitchell, Douglas A. and Moll, Gert N. and Moore, Bradley S. and Mueller, Rolf and Nair, Satish K. and Nes, Ingolf F. and Norris, Gillian E. and Olivera, Baldomero M. and Onaka, Hiroyasu and Patchett, Mark L. and Piel, J{\"o}rn and Reaney, Martin J. T. and Rebuffat, Sylvie and Ross, R. Paul and Sahl, Hans-Georg and Schmidt, Eric W. and Selsted, Michael E. and Severinov, Konstantin and Shen, Ben and Sivonen, Kaarina and Smith, Leif and Stein, Torsten and Suessmuth, Roderich D. and Tagg, John R. and Tang, Gong-Li and Truman, Andrew W. and Vederas, John C. and Walsh, Christopher T. and Walton, Jonathan D. and Wenzel, Silke C. and Willey, Joanne M. and van der Donk, Wilfred A.},
  title     = {Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature},
  series = {Natural product reports : a journal of current developments in bio-organic chemistry},
  volume    = {30},
  journal   = {Natural product reports : a journal of current developments in bio-organic chemistry},
  number    = {1},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {0265-0568},
  doi       = {10.1039/c2np20085f},
  pages     = {108 -- 160},
  year      = {2013},
  abstract  = {This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.},
  language  = {en}
}
@article{TobieTeanbyCoustenisetal.2014,
  author    = {Tobie, G. and Teanby, N. A. and Coustenis, A. and Jaumann, Ralf and Raulin, E. and Schmidt, J. and Carrasco, N. and Coates, Andrew J. and Cordier, D. and De Kok, R. and Geppert, W. D. and Lebreton, J. -P. and Lefevre, A. and Livengood, T. A. and Mandt, K. E. and Mitri, G. and Nimmo, F. and Nixon, C. A. and Norman, L. and Pappalardo, R. T. and Postberg, F. and Rodriguez, S. and SchuizeMakuch, D. and Soderblom, J. M. and Solomonidou, A. and Stephan, K. and Stofan, E. R. and Turtle, E. P. and Wagner, R. J. and West, R. A. and Westlake, J. H.},
  title     = {Science goals and mission concept for the future exploration of Titan and Enceladus},
  series = {Planetary and space science},
  volume    = {104},
  journal   = {Planetary and space science},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0032-0633},
  doi       = {10.1016/j.pss.2014.10.002},
  pages     = {59 -- 77},
  year      = {2014},
  language  = {en}
}
@article{TuckerBoehningGaeseFaganetal.2018,
  author    = {Tucker, Marlee A. and Boehning-Gaese, Katrin and Fagan, William F. and Fryxell, John M. and Van Moorter, Bram and Alberts, Susan C. and Ali, Abdullahi H. and Allen, Andrew M. and Attias, Nina and Avgar, Tal and Bartlam-Brooks, Hattie and Bayarbaatar, Buuveibaatar and Belant, Jerrold L. and Bertassoni, Alessandra and Beyer, Dean and Bidner, Laura and van Beest, Floris M. and Blake, Stephen and Blaum, Niels and Bracis, Chloe and Brown, Danielle and de Bruyn, P. J. Nico and Cagnacci, Francesca and Calabrese, Justin M. and Camilo-Alves, Constanca and Chamaille-Jammes, Simon and Chiaradia, Andre and Davidson, Sarah C. and Dennis, Todd and DeStefano, Stephen and Diefenbach, Duane and Douglas-Hamilton, Iain and Fennessy, Julian and Fichtel, Claudia and Fiedler, Wolfgang and Fischer, Christina and Fischhoff, Ilya and Fleming, Christen H. and Ford, Adam T. and Fritz, Susanne A. and Gehr, Benedikt and Goheen, Jacob R. and Gurarie, Eliezer and Hebblewhite, Mark and Heurich, Marco and Hewison, A. J. Mark and Hof, Christian and Hurme, Edward and Isbell, Lynne A. and Janssen, Rene and Jeltsch, Florian and Kaczensky, Petra and Kane, Adam and Kappeler, Peter M. and Kauffman, Matthew and Kays, Roland and Kimuyu, Duncan and Koch, Flavia and Kranstauber, Bart and LaPoint, Scott and Leimgruber, Peter and Linnell, John D. C. and Lopez-Lopez, Pascual and Markham, A. Catherine and Mattisson, Jenny and Medici, Emilia Patricia and Mellone, Ugo and Merrill, Evelyn and Mourao, Guilherme de Miranda and Morato, Ronaldo G. and Morellet, Nicolas and Morrison, Thomas A. and Diaz-Munoz, Samuel L. and Mysterud, Atle and Nandintsetseg, Dejid and Nathan, Ran and Niamir, Aidin and Odden, John and Oliveira-Santos, Luiz Gustavo R. and Olson, Kirk A. and Patterson, Bruce D. and de Paula, Rogerio Cunha and Pedrotti, Luca and Reineking, Bjorn and Rimmler, Martin and Rogers, Tracey L. and Rolandsen, Christer Moe and Rosenberry, Christopher S. and Rubenstein, Daniel I. and Safi, Kamran and Said, Sonia and Sapir, Nir and Sawyer, Hall and Schmidt, Niels Martin and Selva, Nuria and Sergiel, Agnieszka and Shiilegdamba, Enkhtuvshin and Silva, Joao Paulo and Singh, Navinder and Solberg, Erling J. and Spiegel, Orr and Strand, Olav and Sundaresan, Siva and Ullmann, Wiebke and Voigt, Ulrich and Wall, Jake and Wattles, David and Wikelski, Martin and Wilmers, Christopher C. and Wilson, John W. and Wittemyer, George and Zieba, Filip and Zwijacz-Kozica, Tomasz and Mueller, Thomas},
  title     = {Moving in the Anthropocene},
  series = {Science},
  volume    = {359},
  journal   = {Science},
  number    = {6374},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {0036-8075},
  doi       = {10.1126/science.aam9712},
  pages     = {466 -- 469},
  year      = {2018},
  abstract  = {Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.},
  language  = {en}
}
@article{RusakTanentzapKlugetal.2018,
  author    = {Rusak, James A. and Tanentzap, Andrew J. and Klug, Jennifer L. and Rose, Kevin C. and Hendricks, Susan P. and Jennings, Eleanor and Laas, Alo and Pierson, Donald C. and Ryder, Elizabeth and Smyth, Robyn L. and White, D. S. and Winslow, Luke A. and Adrian, Rita and Arvola, Lauri and de Eyto, Elvira and Feuchtmayr, Heidrun and Honti, Mark and Istvanovics, Vera and Jones, Ian D. and McBride, Chris G. and Schmidt, Silke Regina and Seekell, David and Staehr, Peter A. and Guangwei, Zhu},
  title     = {Wind and trophic status explain within and among-lake variability of algal biomass},
  series = {Limnology and oceanography letters / ASLO, Association for the Sciences of Limnology and Oceanography},
  volume    = {3},
  journal   = {Limnology and oceanography letters / ASLO, Association for the Sciences of Limnology and Oceanography},
  number    = {6},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2378-2242},
  doi       = {10.1002/lol2.10093},
  pages     = {409 -- 418},
  year      = {2018},
  abstract  = {Phytoplankton biomass and production regulates key aspects of freshwater ecosystems yet its variability and subsequent predictability is poorly understood. We estimated within-lake variation in biomass using high-frequency chlorophyll fluorescence data from 18 globally distributed lakes. We tested how variation in fluorescence at monthly, daily, and hourly scales was related to high-frequency variability of wind, water temperature, and radiation within lakes as well as productivity and physical attributes among lakes. Within lakes, monthly variation dominated, but combined daily and hourly variation were equivalent to that expressed monthly. Among lakes, biomass variability increased with trophic status while, within-lake biomass variation increased with increasing variability in wind speed. Our results highlight the benefits of high-frequency chlorophyll monitoring and suggest that predicted changes associated with climate, as well as ongoing cultural eutrophication, are likely to substantially increase the temporal variability of algal biomass and thus the predictability of the services it provides.},
  language  = {en}
}
@article{AldorettaStLouisRichardsonetal.2016,
  author    = {Aldoretta, E. J. and St-Louis, N. and Richardson, N. D. and Moffat, Anthony F. J. and Eversberg, T. and Hill, G. M. and Shenar, Tomer and Artigau, E. and Gauza, B. and Knapen, J. H. and Kubat, Jiř{\´i} and Kubatova, Brankica and Maltais-Tariant, R. and Munoz, M. and Pablo, H. and Ramiaramanantsoa, T. and Richard-Laferriere, A. and Sablowski, D. P. and Simon-Diaz, S. and St-Jean, L. and Bolduan, F. and Dias, F. M. and Dubreuil, P. and Fuchs, D. and Garrel, T. and Grutzeck, G. and Hunger, T. and Kuesters, D. and Langenbrink, M. and Leadbeater, R. and Li, D. and Lopez, A. and Mauclaire, B. and Moldenhawer, T. and Potter, M. and dos Santos, E. M. and Schanne, L. and Schmidt, J. and Sieske, H. and Strachan, J. and Stinner, E. and Stinner, P. and Stober, B. and Strandbaek, K. and Syder, T. and Verilhac, D. and Waldschlaeger, U. and Weiss, D. and Wendt, A.},
  title     = {An extensive spectroscopic time series of three Wolf-Rayet stars - I. The lifetime of large-scale structures in the wind of WR 134},
  series = {Monthly notices of the Royal Astronomical Society},
  volume    = {460},
  journal   = {Monthly notices of the Royal Astronomical Society},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0035-8711},
  doi       = {10.1093/mnras/stw1188},
  pages     = {3407 -- 3417},
  year      = {2016},
  abstract  = {During the summer of 2013, a 4-month spectroscopic campaign took place to observe the variabilities in three Wolf-Rayet stars. The spectroscopic data have been analysed for WR 134 (WN6b), to better understand its behaviour and long-term periodicity, which we interpret as arising from corotating interaction regions (CIRs) in the wind. By analysing the variability of the He ii lambda 5411 emission line, the previously identified period was refined to P = 2.255 +/- 0.008 (s.d.) d. The coherency time of the variability, which we associate with the lifetime of the CIRs in the wind, was deduced to be 40 +/- 6 d, or similar to 18 cycles, by cross-correlating the variability patterns as a function of time. When comparing the phased observational grey-scale difference images with theoretical grey-scales previously calculated from models including CIRs in an optically thin stellar wind, we find that two CIRs were likely present. A separation in longitude of Delta I center dot a parts per thousand integral 90A degrees was determined between the two CIRs and we suggest that the different maximum velocities that they reach indicate that they emerge from different latitudes. We have also been able to detect observational signatures of the CIRs in other spectral lines (C iv lambda lambda 5802,5812 and He i lambda 5876). Furthermore, a DAC was found to be present simultaneously with the CIR signatures detected in the He i lambda 5876 emission line which is consistent with the proposed geometry of the large-scale structures in the wind. Small-scale structures also show a presence in the wind, simultaneously with the larger scale structures, showing that they do in fact co-exist.},
  language  = {en}
}
@article{CuzziBurnsCharnozetal.2010,
  author    = {Cuzzi, Jeff N. and Burns, Joseph A. and Charnoz, S{\´e}bastien and Clark, Roger N. and Colwell, Josh E. and Dones, Luke and Esposito, Larry W. and Filacchione, Gianrico and French, Richard G. and Hedman, Matthew M. and Kempf, Sascha and Marouf, Essam A. and Murray, Carl D. and Nicholson, Phillip D. and Porco, Carolyn C. and Schmidt, J{\"u}rgen and Showalter, Mark R. and Spilker, Linda J. and Spitale, Joseph N. and Srama, Ralf and Sremcević, Miodrag and Tiscareno, Matthew Steven and Weiss, John},
  title     = {An evolving view of Saturn's dynamic rings},
  issn      = {0036-8075},
  doi       = {10.1126/science.1179118},
  year      = {2010},
  abstract  = {We review our understanding of Saturn's rings after nearly 6 years of observations by the Cassini spacecraft. Saturn's rings are composed mostly of water ice but also contain an undetermined reddish contaminant. The rings exhibit a range of structure across many spatial scales; some of this involves the interplay of the fluid nature and the self-gravity of innumerable orbiting centimeter- to meter-sized particles, and the effects of several peripheral and embedded moonlets, but much remains unexplained. A few aspects of ring structure change on time scales as short as days. It remains unclear whether the vigorous evolutionary processes to which the rings are subject imply a much younger age than that of the solar system. Processes on view at Saturn have parallels in circumstellar disks.},
  language  = {en}
}
@article{GottloeberSchmidtStarobinskyetal.1992,
  author    = {Gottl{\"o}ber, Stefan and Schmidt, Hans-J{\"u}rgen and Starobinsky, A. A. and M{\"u}ller, Volker},
  title     = {Models of chaotic inflation},
  series = {Preprint / Universit{\"a}t Potsdam, Fachbereich Mathematik},
  volume    = {1992, 08},
  journal   = {Preprint / Universit{\"a}t Potsdam, Fachbereich Mathematik},
  publisher = {Univ.},
  address   = {Potsdam},
  pages     = {24 S.},
  year      = {1992},
  language  = {en}
}
@article{SchwarzAndraeArnoldetal.1999,
  author    = {Schwarz, W. H. Eugen and Andrae, Dirk and Arnold, S. R. and Heidberg, Joachim and Hellmann jr., H. and Hinze, J. and Karachalios, A. and Kovner, M. A. and Schmidt, P. C. and Z{\"u}licke, Lutz},
  title     = {Hans G. Hellmann (1903 - 1938) : ein deutscher Pionier der Quantenchemie in Moskau},
  year      = {1999},
  language  = {de}
}
@article{SchwarzAndraeArnoldetal.1999,
  author    = {Schwarz, W. H. Eugen and Andrae, Dirk and Arnold, S. R. and Heidberg, Joachim and Hellmann jr., H. and Hinze, J. and Karachalios, A. and Kovner, M. A. and Schmidt, P. C. and Z{\"u}licke, Lutz},
  title     = {Hans G. Hellmann (1903 - 1938) : ein Pionier der Quantenchemie},
  year      = {1999},
  language  = {de}
}
@article{WeberAbuAyyashAbueladasetal.2004,
  author    = {Weber, Michael H. and Abu-Ayyash, Khalil and Abueladas, Abdel-Rahman and Agnon, Amotz and Al-Amoush, H. and Babeyko, Andrey and Bartov, Yosef and Baumann, M. and Ben-Avraham, Zvi and Bock, G{\"u}nter and Bribach, Jens and El-Kelani, R. and Forster, A. and F{\"o}rster, Hans-J{\"u}rgen and Frieslander, U. and Garfunkel, Zvi and Grunewald, Steffen and Gotze, Hans-J{\"u}rgen and Haak, Volker and Haberland, Christian and Hassouneh, Mohammed and Helwig, S. and Hofstetter, Alfons and Jackel, K. H. and Kesten, Dagmar and Kind, Rainer and Maercklin, Nils and Mechie, James and Mohsen, Amjad and Neubauer, F. M. and Oberh{\"a}nsli, Roland and Qabbani, I. and Ritter, O. and Rumpker, G. and Rybakov, M. and Ryberg, Trond and Scherbaum, Frank and Schmidt, J. and Schulze, A. and Sobolev, Stephan Vladimir and Stiller, M. and Th,},
  title     = {The crustal structure of the Dead Sea Transform},
  year      = {2004},
  abstract  = {To address one of the central questions of plate tectonics-How do large transform systems work and what are their typical features?-seismic investigations across the Dead Sea Transform (DST), the boundary between the African and Arabian plates in the Middle East, were conducted for the first time. A major component of these investigations was a combined reflection/ refraction survey across the territories of Palestine, Israel and Jordan. The main results of this study are: (1) The seismic basement is offset by 3-5 km under the DST, (2) The DST cuts through the entire crust, broadening in the lower crust, (3) Strong lower crustal reflectors are imaged only on one side of the DST, (4) The seismic velocity sections show a steady increase in the depth of the crust-mantle transition (Moho) from 26 km at the Mediterranean to 39 km under the Jordan highlands, with only a small but visible, asymmetric topography of the Moho under the DST. These observations can be linked to the left-lateral movement of 105 km of the two plates in the last 17 Myr, accompanied by strong deformation within a narrow zone cutting through the entire crust. Comparing the DST and the San Andreas Fault (SAF) system, a strong asymmetry in subhorizontal lower crustal reflectors and a deep reaching deformation zone both occur around the DST and the SAF. The fact that such lower crustal reflectors and deep deformation zones are observed in such different transform systems suggests that these structures are possibly fundamental features of large transform plate boundaries},
  language  = {en}
}
@article{BeckerGeigerDunkeletal.2004,
  author    = {Becker, Dirk and Geiger, D. and Dunkel, M. and Roller, A. and Bertl, Adam and Latz, A. and Carpaneto, Armando and Dietrich, Peter and Roelfsema, M. R. G. and Voelker, C. and Schmidt, D. and M{\"u}ller-R{\"o}ber, Bernd and Czempinski, Katrin and Hedrich, R.},
  title     = {AtTPK4, an Arabidopsis tandem-pore K+ channel, poised to control the pollen membrane voltage in a pH- and Ca2+- dependent manner},
  issn      = {0027-8424},
  year      = {2004},
  abstract  = {The Arabidopsis tandem-pore K+ (TPK) channels displaying four transmembrane domains and two pore regions share structural homologies with their animal counterparts of the KCNK family. In contrast to the Shaker-like Arabidopsis channels (six transmembrane domains/one pore region), the functional properties and the biological role of plant TPK channels have not been elucidated yet. Here, we show that AtTPK4 (KCO4) localizes to the plasma membrane and is predominantly expressed in pollen. AtTPK4 (KCO4) resembles the electrical properties of a voltage-independent K+ channel after expression in Xenopus oocytes and yeast. Hyperpolarizing as well as depolarizing membrane voltages elicited instantaneous K+ currents, which were blocked by extracellular calcium and cytoplasmic protons. Functional complementation assays using a K+ transport-deficient yeast confirmed the biophysical and pharmacological properties of the AtTPK4 channel. The features of AtTPK4 point toward a role in potassium homeostasis and membrane voltage control of the growing pollen tube. Thus, AtTPK4 represents a member of plant tandem-pore-K+ channels, resembling the characteristics of its animal counterparts as well as plant-specific features with respect to modulation of channel activity by acidosis and calcium},
  language  = {en}
}
@article{WisotzkiBaconBrinchmannetal.2018,
  author    = {Wisotzki, Lutz and Bacon, R. and Brinchmann, J. and Cantalupo, S. and Richter, Philipp and Schaye, J. and Schmidt, Kasper Borello and Urrutia, Tanya and Weilbacher, Peter Michael and Akhlaghi, M. and Bouche, N. and Contini, T. and Guiderdoni, B. and Herenz, E. C. and Inami, H. and Kerutt, Josephine Victoria and Leclercq, F. and Marino, R. A. and Maseda, M. and Monreal-Ibero, A. and Nanayakkara, T. and Richard, J. and Saust, R. and Steinmetz, Matthias and Wendt, Martin},
  title     = {Nearly all the sky is covered by Lyman-alpha emission around high-redshift galaxies},
  series = {Nature : the international weekly journal of science},
  volume    = {562},
  journal   = {Nature : the international weekly journal of science},
  number    = {7726},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0028-0836},
  doi       = {10.1038/s41586-018-0564-6},
  pages     = {229 -- 232},
  year      = {2018},
  abstract  = {Galaxies are surrounded by large reservoirs of gas, mostly hydrogen, that are fed by inflows from the intergalactic medium and by outflows from galactic winds. Absorption-line measurements along the lines of sight to bright and rare background quasars indicate that this circumgalactic medium extends far beyond the starlight seen in galaxies, but very little is known about its spatial distribution. The Lyman-alpha transition of atomic hydrogen at a wavelength of 121.6 nanometres is an important tracer of warm (about 104 kelvin) gas in and around galaxies, especially at cosmological redshifts greater than about 1.6 at which the spectral line becomes observable from the ground. Tracing cosmic hydrogen through its Lyman-a emission has been a long-standing goal of observational astrophysics(1-3), but the extremely low surface brightness of the spatially extended emission is a formidable obstacle. A new window into circumgalactic environments was recently opened by the discovery of ubiquitous extended Lyman-alpha emission from hydrogen around high-redshift galaxies(4,5). Such measurements were previously limited to especially favourable systems(6-8) or to the use of massive statistical averaging(9,10) because of the faintness of this emission. Here we report observations of low-surface-brightness Lyman-alpha emission surrounding faint galaxies at redshifts between 3 and 6. We find that the projected sky coverage approaches 100 per cent. The corresponding rate of incidence (the mean number of Lyman-alpha emitters penetrated by any arbitrary line of sight) is well above unity and similar to the incidence rate of high-column-density absorbers frequently detected in the spectra of distant quasars(11-14). This similarity suggests that most circumgalactic atomic hydrogen at these redshifts has now been detected in emission.},
  language  = {en}
}
@article{NchiozemNgnitedemSperlichMatietaetal.2023,
  author    = {Nchiozem-Ngnitedem, Vaderament-Alexe and Sperlich, Eric and Matieta, Valaire Yemene and Kuete, Jenifer Reine Ngnouzouba and Kuete, Victor and Omer, Ejlal A. A. and Efferth, Thomas and Schmidt, Bernd},
  title     = {Synthesis and bioactivity of isoflavones from ficus carica and some non-natural analogues},
  series = {Journal of natural products : Lloydia},
  volume    = {86},
  journal   = {Journal of natural products : Lloydia},
  number    = {6},
  publisher = {American Chemical Society},
  address   = {Washington, DC},
  issn      = {0163-3864},
  doi       = {10.1021/acs.jnatprod.3c00219},
  pages     = {1520 -- 1528},
  year      = {2023},
  abstract  = {FicucariconeD (1) and its 4 '-demethyl congener 2 are isoflavones isolated from fruits of Ficus carica that share a 5,7-dimethoxy-6-prenyl-substituted A-ring. Both naturalproducts were, for the first time, obtained by chemical synthesisin six steps, starting from 2,4,6-trihydroxyacetophenone. Key stepsare a microwave-promoted tandem sequence of Claisen- and Cope-rearrangementsto install the 6-prenyl substituent and a Suzuki-Miyaura crosscoupling for installing the B-ring. By using various boronic acids,non-natural analogues become conveniently available. All compoundswere tested for cytotoxicity against drug-sensitive and drug-resistanthuman leukemia cell lines, but were found to be inactive. The compoundswere also tested for antimicrobial activities against a panel of eightGram-negative and two Gram-positive bacterial strains. Addition ofthe efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide(PA beta N) significantly improved the antibiotic activity in mostcases, with MIC values as low as 2.5 mu M and activity improvementfactors as high as 128-fold.},
  language  = {en}
}
@article{GilingStaehrGrossartetal.2017,
  author    = {Giling, Darren P. and Staehr, Peter A. and Grossart, Hans-Peter and Andersen, Mikkel Rene and Boehrer, Bertram and Escot, Carmelo and Evrendilek, Fatih and Gomez-Gener, Lluis and Honti, Mark and Jones, Ian D. and Karakaya, Nusret and Laas, Alo and Moreno-Ostos, Enrique and Rinke, Karsten and Scharfenberger, Ulrike and Schmidt, Silke R. and Weber, Michael and Woolway, R. Iestyn and Zwart, Jacob A. and Obrador, Biel},
  title     = {Delving deeper: Metabolic processes in the metalimnion of stratified lakes},
  series = {Limnology and oceanography},
  volume    = {62},
  journal   = {Limnology and oceanography},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0024-3590},
  doi       = {10.1002/lno.10504},
  pages     = {1288 -- 1306},
  year      = {2017},
  abstract  = {Many lakes exhibit seasonal stratification, during which they develop strong thermal and chemical gradients. An expansion of depth-integrated monitoring programs has provided insight into the importance of organic carbon processing that occurs below the upper mixed layer. However, the chemical and physical drivers of metabolism and metabolic coupling remain unresolved, especially in the metalimnion. In this depth zone, sharp gradients in key resources such as light and temperature co-occur with dynamic physical conditions that influence metabolic processes directly and simultaneously hamper the accurate tracing of biological activity. We evaluated the drivers of metalimnetic metabolism and its associated uncertainty across 10 stratified lakes in Europe and North America. We hypothesized that the metalimnion would contribute highly to whole-lake functioning in clear oligotrophic lakes, and that metabolic rates would be highly variable in unstable polymictic lakes. Depth-integrated rates of gross primary production (GPP) and ecosystem respiration (ER) were modelled from diel dissolved oxygen curves using a Bayesian approach. Metabolic estimates were more uncertain below the epilimnion, but uncertainty was not consistently related to lake morphology or mixing regime. Metalimnetic rates exhibited high day-to-day variability in all trophic states, with the metalimnetic contribution to daily whole-lake GPP and ER ranging from 0\% to 87\% and < 1\% to 92\%, respectively. Nonetheless, the metalimnion of low-nutrient lakes contributed strongly to whole-lake metabolism on average, driven by a collinear combination of highlight, low surface-water phosphorous concentration and high metalimnetic volume. Consequently, a single-sensor approach does not necessarily reflect whole-ecosystem carbon dynamics in stratified lakes.},
  language  = {en}
}
@article{SchulteMeucciStoofLeichsenringetal.2022,
  author    = {Schulte, Luise and Meucci, Stefano and Stoof-Leichsenring, Kathleen R. and Heitkam, Tony and Schmidt, Nicola and von Hippel, Barbara and Andreev, Andrei A. and Diekmann, Bernhard and Biskaborn, Boris and Wagner, Bernd and Melles, Martin and Pestryakova, Lyudmila A. and Alsos, Inger G. and Clarke, Charlotte and Krutovsky, Konstantin and Herzschuh, Ulrike},
  title     = {Larix species range dynamics in Siberia since the Last Glacial captured from sedimentary ancient DNA},
  series = {Communications biology},
  volume    = {5},
  journal   = {Communications biology},
  number    = {1},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2399-3642},
  doi       = {10.1038/s42003-022-03455-0},
  pages     = {11},
  year      = {2022},
  abstract  = {Climate change is expected to cause major shifts in boreal forests which are in vast areas of Siberia dominated by two species of the deciduous needle tree larch (Larix). The species differ markedly in their ecosystem functions, thus shifts in their respective ranges are of global relevance. However, drivers of species distribution are not well understood, in part because paleoecological data at species level are lacking. This study tracks Larix species distribution in time and space using target enrichment on sedimentary ancient DNA extracts from eight lakes across Siberia. We discovered that Larix sibirica, presently dominating in western Siberia, likely migrated to its northern distribution area only in the Holocene at around 10,000 years before present (ka BP), and had a much wider eastern distribution around 33 ka BP. Samples dated to the Last Glacial Maximum (around 21 ka BP), consistently show genotypes of L. gmelinii. Our results suggest climate as a strong determinant of species distribution in Larix and provide temporal and spatial data for species projection in a changing climate. Using ancient sedimentary DNA from up to 50 kya, dramatic distributional shifts are documented in two dominant boreal larch species, likely guided by environmental changes suggesting climate as a strong determinant of species distribution.},
  language  = {en}
}
@article{RothwellMurphyAleksandrovaetal.2020,
  author    = {Rothwell, Joseph A. and Murphy, Neil and Aleksandrova, Krasimira and Schulze, Matthias Bernd and Bešević, Jelena and Kliemann, Nathalie and Jenab, Mazda and Ferrari, Pietro and Achaintre, David and Gicquiau, Audrey and Vozar, B{\´e}atrice and Scalbert, Augustin and Huybrechts, Inge and Freisling, Heinz and Prehn, Cornelia and Adamski, Jerzy and Cross, Amanda J. and Pala, Valeria Maria and Boutron-Ruault, Marie-Christine and Dahm, Christina C. and Overvad, Kim and Gram, Inger Torhild and Sandanger, Torkjel M. and Skeie, Guri and Jakszyn, Paula and Tsilidis, Kostas K. and Hughes, David J. and van Guelpen, Bethany and Bod{\´e}n, Stina and S{\´a}nchez, Maria-Jos{\´e} and Schmidt, Julie A. and Katzke, Verena and K{\"u}hn, Tilman and Colorado-Yohar, Sandra and Tumino, Rosario and Bueno-de-Mesquita, Bas and Vineis, Paolo and Masala, Giovanna and Panico, Salvatore and Eriksen, Anne Kirstine and Tj{\o}nneland, Anne and Aune, Dagfinn and Weiderpass, Elisabete and Severi, Gianluca and Chaj{\`e}s, V{\´e}ronique and Gunter, Marc J.},
  title     = {Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort},
  series = {Clinical gastroenterology and hepatology},
  volume    = {20},
  journal   = {Clinical gastroenterology and hepatology},
  publisher = {Elsevier},
  address   = {New York, NY},
  issn      = {1542-3565},
  doi       = {10.1016/j.cgh.2020.11.045},
  pages     = {E1061 -- E1082},
  year      = {2020},
  abstract  = {BACKGROUND \& AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95\% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95\% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95\% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95\% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.},
  language  = {en}
}
@article{RuhlFritzscheVermotetal.2006,
  author    = {Ruhl, R. and Fritzsche, Britta and Vermot, J. and Niederreither, K. and Neumann, U. and Schmidt, A. and Schweigert, Florian J. and Dolle, P.},
  title     = {Regulation of expression of the retinoic acid-synthesising enzymes retinaldehyde dehydrogenases in the uteri of ovariectomised mice after treatment with oestrogen, gestagen and their combination},
  year      = {2006},
  abstract  = {The active metabolite of vitaminA, retinoic acid (RA), plays an important role in the female reproductive system. The synthesis of RA is tightly regulated by the activity of retinaldehyde dehydrogenases (Raldh). Among these, Raldh1 and Raldh2 exhibit specific temporal and spatial expression patterns in the mouse uterus, both during the oestrous cycle and early pregnancy. In the present study, we have assessed whether oestradiol and progesterone directly influence the uterine expression of Raldh1 and Raldh2 in ovariectomised mice. We investigated the effect of gestagen (promegestone 0.3 mg kg(-1) bodyweight), oestrogen (oestradiol 3 mu g kg(-1) bodyweight) and their combination on the uterine expression of Raldh2. Expression was analysed using in situ hybridisation and quantified using real-time detection reverse transcription-polymerase chain reaction. The results show that the expression of Raldh2 is rapidly (within 1-4 h) induced in stromal cells by oestrogen, but not by gestagen, treatment, whereas combined oestrogen + gestagen treatment leads to a more prolonged (48 h) response. In contrast, oestrogen, but not progesterone, treatment downregulates (within 4 - 24 h) Raldh1 expression in the uterine glandular epithelium. We conclude that the uterine RA concentrations are regulated by oestrogens via an effect on the expression of the Raldh synthesising enzymes. Such a regulation is consistent with the natural fluctuations of Raldh expression during the oestrous cycle, early pregnancy and blastocyst implantation},
  language  = {en}
}
@article{AllenSchmidtEbelingetal.2004,
  author    = {Allen, S. W. and Schmidt, Robert W. and Ebeling, H. and Fabian, A. C. and van Speybroeck, L.},
  title     = {Constraints on dark energy from Chandra observations of the largest relaxed galaxy clusters},
  issn      = {0035-8711},
  year      = {2004},
  abstract  = {We present constraints on the mean dark energy density, Omega(X) and dark energy equation of state parameter, w(X), based on Chandra measurements of the X-ray gas mass fraction in 26 X-ray luminous, dynamically relaxed galaxy clusters spanning the redshift range 0.07 < z < 0.9. Under the assumption that the X-ray gas mass fraction measured within r(2500) is constant with redshift and using only weak priors on the Hubble constant and mean baryon density of the Universe, we obtain a clear detection of the effects of dark energy on the distances to the clusters, confirming (at comparable significance) previous results from Type la supernovae studies. For a standard Lambda cold dark matter (CDM) cosmology with the curvature Omega(K) included as a free parameter, we find Omega(Lambda) = 0.94(-0.23)(+0.21) (68 per cent confidence limits). We also examine extended XCDM dark energy models. Combining the Chandra data with independent constraints from cosmic microwave background experiments, we find Omega(X) = 0.75 +/- 0.04, Omega(m) = 0.26(- 0.04)(+0.06) and w(X) =-1.26 +/- 0.24. Imposing the prior constraint w(X) > -1, the same data require w(X) < -0.7 at 95 per cent confidence. Similar results on the mean matter density and dark energy equation of state parameter, \&UOmega;(m) = 0.24 ± 0.04 and w(X) 1.20(-0.28)(+0.24), are obtained by replacing the cosmic microwave background data with standard priors on the Hubble constant and mean baryon density and assuming a flat geometry},
  language  = {en}
}
@article{GoldmannNordsieckJanietzetal.2004,
  author    = {Goldmann, Daniela and Nordsieck, A. and Janietz, Dietmar and Frese, T. and Schmidt, C. and Wendorff, Joachim Heinz},
  title     = {Smectic and columnar liquid crystalline phases through charge-transfer interactions},
  issn      = {1058-725X},
  year      = {2004},
  abstract  = {New heterocyclic electron donors based on. a 1,3,5-triazine nucleus are presented. Three phenyl rings are grafted to the triazine core either via secondary amino groups or by a direct C,C-linkage and a specific number of decyloxy chains is attached to the molecular periphery. The compounds are non-liquid crystalline in their pure states. Lamellar or columnar mesophases are induced by attractive interactions with electron acceptors},
  language  = {en}
}
@article{KressJarrinThuroffetal.2004,
  author    = {Kress, H. and Jarrin, A. and Thuroff, E. and Saunders, R. and Weise, C. and Schmidt am Busch, Marcel and Knapp, E. W. and Wedde, M. and Vilcinskas, Andreas},
  title     = {A Kunitz type protease inhibitor related protein is synthesized in Drosophila prepupal salivary glands and released into the moulting fluid during pupation},
  issn      = {0965-1748},
  year      = {2004},
  abstract  = {From the Drosophila virilis late puff region 31C, we microcloned two neighbouring genes, Kil-1 and Kil-2, that encode putative Kunitz serine protease inhibitor like proteins. The Kil-1 gene is expressed exclusively in prepupal salivary glands. Using a size mutant of the KIL-1 protein and MALDI-TOF analysis, we demonstrate that during pupation this protein is released from the prepupal salivary glands into the pupation fluid covering the surface of the pupa. 3-D- structure predictions are consistent with the known crystal structure of the human Kunitz type protease inhibitor 2KNT. This is the first experimental proof for the extra-corporal presence of a distinct Drosophila prepupal salivary gland protein. Possible functions of KIL-1 in the context of the control of proteolytic activities in the pupation fluid are discussed. (C) 2004 Elsevier Ltd. All rights reserved},
  language  = {en}
}
@article{SchmidtAllenFabian2004,
  author    = {Schmidt, Robert W. and Allen, S. W. and Fabian, A. C.},
  title     = {An improved approach to measuring H-0 using X-ray and SZ observations of galaxy clusters},
  issn      = {0035-8711},
  year      = {2004},
  abstract  = {We present an improved method for predicting the Sunyaev-Zeldovich (SZ) effect in galaxy clusters from spatially resolved, spectroscopic X-ray data. Using the deprojected electron density and temperature profiles measured within a fraction of the virial radius, and assuming a Navarro-Frenk-White mass model, we show how the pressure profile of the X-ray gas can be extrapolated to large radii, allowing the Comptonization parameter profile for the cluster to be predicted precisely. We apply our method to Chandra observations of three X-ray-luminous, dynamically relaxed clusters with published SZ data: RX J1347.5-1145, Abell 1835 and Abell 478. Combining the predicted and observed SZ signals, we determine improved estimates for the Hubble constant from each cluster and obtain a weighted mean of H (0) = 69 +/- 8 km s(-1) Mpc(-1) for a cosmology with Omega(m) = 0.3 and Omega(Lambda) = 0.7. This result is in good agreement with independent findings from the Hubble Key Project and the combination of cosmic microwave background and galaxy cluster data},
  language  = {en}
}
@article{RickertLendleinSchmidtetal.2003,
  author    = {Rickert, D. and Lendlein, Andreas and Schmidt, A. M. and Kelch, S. and Roehlke, W. and Fuhrmann, R. and Franke, R. P.},
  title     = {In vitro cytotoxicity testing of AB-polymer networks based on oligo(epsilon-caprolactone) segments after different sterilization techniques},
  year      = {2003},
  language  = {en}
}
@article{GorbatenkoPushkinSchmidt2002,
  author    = {Gorbatenko, M. V. and Pushkin, A. V. and Schmidt, Hans-J{\"u}rgen},
  title     = {On a relation between the Bach equation and the equation of geometrodynamics},
  year      = {2002},
  abstract  = {The Bach equation and the equation of geometrodynamics are based on two quite different physical motivations, but in both approaches, the conformal properties of gravitation plays the key role. In this paper we present an analysis of the relation between these two equations and show that the solutions of the equation of geometrodynamics are of a more general nature. We show the following non-trivial result: there exists a conformally invariant Lagrangian, whose field equation generalizes the Bach equation and has as solutions those Ricci tensors which are solutions to the equation of geometrodynamics.},
  language  = {en}
}
@article{WalzSchmidtRuizFrauetal.2019,
  author    = {Walz, Ariane and Schmidt, Katja and Ruiz-Frau, Ana and Nicholas, Kimberly A. and Bierry, Adeline and Lentsch, Aster de Vries and Dyankov, Apostol and Joyce, Deirdre and Liski, Anja H. and Marba, Nuria and Rosario, Ines T. and Scholte, Samantha S. K.},
  title     = {Sociocultural valuation of ecosystem services for operational ecosystem management: mapping applications by decision contexts in Europe},
  series = {Regional environmental change},
  volume    = {19},
  journal   = {Regional environmental change},
  number    = {8},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {1436-3798},
  doi       = {10.1007/s10113-019-01506-7},
  pages     = {2245 -- 2259},
  year      = {2019},
  abstract  = {Sociocultural valuation (SCV) of ecosystem services (ES) discloses the principles, importance or preferences expressed by people towards nature. Although ES research has increasingly addressed sociocultural values in past years, little effort has been made to systematically review the components of sociocultural valuation applications for different decision contexts (i.e. awareness raising, accounting, priority setting, litigation and instrument design). In this analysis, we investigate the characteristics of 48 different sociocultural valuation applications—characterised by unique combinations of decision context, methods, data collection formats and participants—across ten European case studies. Our findings show that raising awareness for the sociocultural value of ES by capturing people's perspective and establishing the status quo, was found the most frequent decision context in case studies, followed by priority setting and instrument development. Accounting and litigation issues were not addressed in any of the applications. We reveal that applications for particular decision contexts are methodologically similar, and that decision contexts determine the choice of methods, data collection formats and participants involved. Therefore, we conclude that understanding the decision context is a critical first step to designing and carrying out fit-for-purpose sociocultural valuation of ES in operational ecosystem management.},
  language  = {en}
}
@article{WuHanRodriguezSillkeetal.2019,
  author    = {Wu, Hao and Han, Yijie and Rodriguez Sillke, Yasmina and Deng, Hongzhang and Siddiqui, Sophiya and Treese, Christoph and Schmidt, Franziska and Friedrich, Marie and Keye, Jacqueline and Wan, Jiajia and Qin, Yue and K{\"u}hl, Anja A. and Qin, Zhihai and Siegmund, Britta and Glauben, Rainer},
  title     = {Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages},
  series = {EMBO molecular medicine},
  volume    = {11},
  journal   = {EMBO molecular medicine},
  number    = {11},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1757-4676},
  doi       = {10.15252/emmm.201910698},
  pages     = {17},
  year      = {2019},
  abstract  = {Tumor-associated macrophages (TAMs) promote tumor growth and metastasis by suppressing tumor immune surveillance. Herein, we provide evidence that the immunosuppressive phenotype of TAMs is controlled by long-chain fatty acid metabolism, specifically unsaturated fatty acids, here exemplified by oleate. Consequently, en-route enriched lipid droplets were identified as essential organelles, which represent effective targets for chemical inhibitors to block in vitro polarization of TAMs and tumor growth in vivo. In line, analysis of human tumors revealed that myeloid cells infiltrating colon cancer but not gastric cancer tissue indeed accumulate lipid droplets. Mechanistically, our data indicate that oleate-induced polarization of myeloid cells depends on the mammalian target of the rapamycin pathway. Thus, our findings reveal an alternative therapeutic strategy by targeting the pro-tumoral myeloid cells on a metabolic level.},
  language  = {en}
}
@article{RaderFauthGouldetal.2005,
  author    = {Rader, Oliver and Fauth, K. and Gould, C. and Ruster, C. and Schott, G. M. and Schmidt, G. and Brunner, K. and Molenkamp, Laurens W. and Schutz, G. and Kronast, F. and Durr, H. A. and Eberhardt, W. and Gudat, Wolfgang},
  title     = {Identification of extrinsic Mn contributions in Ga1-xMnxAs by field-dependent magnetic circular X-ray dichroism},
  issn      = {0368-2048},
  year      = {2005},
  abstract  = {We combine sensitivity to atomic number, chemical shifts, probing depth, and magnetic order in a field- dependent magnetic circular X-ray dichroism study at the Mn L-edge of the diluted ferromagnetic semiconductor Ga1-xMnxAs and observe different Mn constituents: ferromagnetic Mn with an n(d) > 5 lineshape and paramagnetic Mn with distinct n(d) = 5 lineshape. The paramagnetic Mn is assigned to interstitials with surface segregation tendency. (c) 2005 Elsevier B.V. All rights reserved},
  language  = {en}
}
@article{ToetzkeGaiselmannOsenbergetal.2016,
  author    = {T{\"o}tzke, Christian and Gaiselmann, G. and Osenberg, M. and Arlt, T. and Mark{\"o}tter, H. and Hilger, A. and Kupsch, Andreas and M{\"u}ller, B. R. and Schmidt, V. and Lehnert, W. and Manke, Ingo},
  title     = {Influence of hydrophobic treatment on the structure of compressed gas diffusion layers},
  series = {Journal of power sources : the international journal on the science and technology of electrochemical energy systems},
  volume    = {324},
  journal   = {Journal of power sources : the international journal on the science and technology of electrochemical energy systems},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0378-7753},
  doi       = {10.1016/j.jpowsour.2016.05.118},
  pages     = {625 -- 636},
  year      = {2016},
  abstract  = {Carbon fiber based felt materials are widely used as gas diffusion layer (GDL) in fuel cells. Their transport properties can be adjusted by adding hydrophobic agents such as polytetrafluoroethylene (PTFE). We present a synchrotron X-ray tomographic study on the felt material Freudenberg H2315 with different PIPE finishing. In this study, we analyze changes in microstructure and shape of GDLs at increasing degree of compression which are related to their specific PTFE load. A dedicated compression device mimicking the channel-land pattern of the flowfield is used to reproduce the inhomogeneous compression found in a fuel cell. Transport relevant geometrical parameters such as porosity, pore size distribution and geometric tortuosity are calculated and consequences for media transport discussed. PTFE finishing results in a marked change of shape of compressed GDLs: surface is smoothed and the invasion of GDL fibers into the flow field channel strongly mitigated. Furthermore, the PTFE impacts the microstructure of the compressed GDL. The number of available wide transport paths is significantly increased as compared to the untreated material. These changes improve the transport capacity liquid water through the GDL and promote the discharge of liquid water droplets from the cell. (C) 2016 Elsevier B.V. All rights reserved.},
  language  = {en}
}
@article{GoldmannMahlstedtJanietzetal.1998,
  author    = {Goldmann, Daniela and Mahlstedt, S. and Janietz, Dietmar and Busch, P. and Schmidt, C. and Stracke, A. and Wendorff, Joachim Heinz},
  title     = {Mesomorphic donor-acceptor twin molecules with covalently linked sheet-like pentaalkyne and nitrofluorenone subunits},
  year      = {1998},
  language  = {en}
}
@book{RauhSchmidtDenterPerrezetal.1995,
  author    = {Rauh, Hellgard and Schmidt-Denter, U. and Perrez, M. and Krapp, A.},
  title     = {Psychologie in Erziehung und Unterricht : Zeitschrift f{\"u}r Forschung und Praxis},
  publisher = {Reinhardt},
  address   = {M{\"u}nchen},
  issn      = {0342-183X},
  year      = {1995},
  language  = {de}
}
@article{TiscarenoMitchellMurrayetal.2013,
  author    = {Tiscareno, Matthew S. and Mitchell, Colin J. and Murray, Carl D. and Di Nino, Daiana and Hedman, Matthew M. and Schmidt, J{\"u}rgen and Burns, Joseph A. and Cuzzi, Jeffrey N. and Porco, Carolyn C. and Beurle, Kevin and Evans, Michael W.},
  title     = {Observations of Ejecta clouds produced by impacts onto Saturn's rings},
  series = {Science},
  volume    = {340},
  journal   = {Science},
  number    = {6131},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {0036-8075},
  doi       = {10.1126/science.1233524},
  pages     = {460 -- 464},
  year      = {2013},
  abstract  = {We report observations of dusty clouds in Saturn's rings, which we interpret as resulting from impacts onto the rings that occurred between 1 and 50 hours before the clouds were observed. The largest of these clouds was observed twice; its brightness and cant angle evolved in a manner consistent with this hypothesis. Several arguments suggest that these clouds cannot be due to the primary impact of one solid meteoroid onto the rings, but rather are due to the impact of a compact stream of Saturn-orbiting material derived from previous breakup of a meteoroid. The responsible interplanetary meteoroids were initially between 1 centimeter and several meters in size, and their influx rate is consistent with the sparse prior knowledge of smaller meteoroids in the outer solar system.},
  language  = {en}
}
@article{KoenneckeFollathPontiusetal.2013,
  author    = {K{\"o}nnecke, Rene and Follath, R. and Pontius, N. and Schlappa, J. and Eggenstein, F. and Zeschke, T. and Bischoff, P. and Schmidt, J. -S. and Noll, T. and Trabant, C. and Schreck, S. and Wernet, Ph. and Eisebitt, S. and Senf, F. and Schuessler-Langeheine, Christian and Erko, A. and F{\"o}hlisch, Alexander},
  title     = {The confocal plane grating spectrometer at BESSY II},
  series = {Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy},
  volume    = {188},
  journal   = {Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0368-2048},
  doi       = {10.1016/j.elspec.2012.11.003},
  pages     = {133 -- 139},
  year      = {2013},
  abstract  = {At BESSY II a confocal plane grating spectrometer for resonant inelastic X-ray scattering (RIXS) is currently under commissioning. The new endstation operates with a source size of 4 x 1 mu m(2) provided by its dedicated beamline. The RIXS-spectrometer covers an energy range from 50 eV to 1000 eV, providing a resolving power E/Delta E of 5000-15,000. The beamline allows full polarization control and gives a photon flux of up to 7 x 10(14) photons/s/0.1 A/0.1\%bandwidth by offering a resolving power E/Delta E of 4000-12,000.},
  language  = {en}
}
@article{SongBergstrasserRafatetal.2009,
  author    = {Song, Hui and Bergstrasser, Claudia and Rafat, Neysan and Hoeger, Simone and Schmidt, Marc and Endres, N. and Goebeler, Matthias and Hillebrands, Jan-Luuk and Brigelius-Floh{\´e}, Regina and Banning, Antje and Beck, Grietje and Loesel, Ralf and Yard, Benito A.},
  title     = {The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E- selectin independently of haem oxygenase-1 expression},
  issn      = {0007-1188},
  doi       = {10.1111/j.1476-5381.2009.00215.x},
  year      = {2009},
  abstract  = {Background and purpose: Although carbon monoxide (CO) can modulate inflammatory processes, the influence of CO on adhesion molecules is less clear. This might be due to the limited amount of CO generated by haem degradation. We therefore tested the ability of a CO releasing molecule (CORM-3), used in supra-physiological concentrations, to modulate the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin on endothelial cells and the mechanism(s) involved. Experimental approach: Human umbilical vein endothelial cells (HUVECs) were stimulated with tumour necrosis factor (TNF)-alpha in the presence or absence of CORM-3. The influence of CORM-3 on VCAM-1 and E- selectin expression and the nuclear factor (NF)-kappa B pathway was assessed by flow cytometry, Western blotting and electrophoretic mobility shift assay. Key results: CORM-3 inhibited the expression of VCAM-1 and E-selectin on TNF-alpha- stimulated HUVEC. VCAM-1 expression was also inhibited when CORM-3 was added 24 h after TNF-alpha stimulation or when TNF-alpha was removed. This was paralleled by deactivation of NF-kappa B and a reduction in VCAM-1 mRNA. Although TNF- alpha removal was more effective in this regard, VCAM-1 protein was down-regulated more rapidly when CORM-3 was added. CORM-3 induced haem oxygenase-1 (HO-1) in a dose- and time-dependent manner, mediated by the transcription factor, Nrf2. CORM-3 was still able to down-regulate VCAM-1 expression in HUVEC transfected with siRNA for HO-1 or Nrf2. Conclusions and implications: Down-regulation of VCAM and E-selectin expression induced by CORM-3 was independent of HO-1 up- regulation and was predominantly due to inhibition of sustained NF-kappa B activation.},
  language  = {en}
}
@article{JonesArridgeCoatesetal.2009,
  author    = {Jones, Geraint H. and Arridge, Christopher S. and Coates, Andrew J. and Lewis, Gethyn R. and Kanani, Sheila and Wellbrock, Anne and Young, David T. and Crary, Frank J. and Tokar, Robert L. and Wilson, R. J. and Hill, Thomas W. and Johnson, Robert E. and Mitchell, Donald G. and Schmidt, J{\"u}rgen and Kempf, Sascha and Beckmann, Uwe and Russell, Christopher T. and Jia, Y. D. and Dougherty, Michele K. and Waite, J. Hunter and Magee, Brian A.},
  title     = {Fine jet structure of electrically charged grains in Enceladus' plume},
  issn      = {0094-8276},
  doi       = {10.1029/2009gl038284},
  year      = {2009},
  abstract  = {By traversing the plume erupting from high southern latitudes on Saturn's moon Enceladus, Cassini orbiter instruments can directly sample the material therein. Cassini Plasma Spectrometer, CAPS, data show that a major plume component comprises previously-undetected particles of nanometer scales and larger that bridge the mass gap between previously observed gaseous species and solid icy grains. This population is electrically charged both negative and positive, indicating that subsurface triboelectric charging, i.e., contact electrification of condensed plume material may occur through mutual collisions within vents. The electric field of Saturn's magnetosphere controls the jets' morphologies, separating particles according to mass and charge. Fine-scale structuring of these particles' spatial distribution correlates with discrete plume jets' sources, and reveals locations of other possible active regions. The observed plume population likely forms a major component of high velocity nanometer particle streams detected outside Saturn's magnetosphere.},
  language  = {en}
}
@article{FreilinghausKocmitBorketal.1998,
  author    = {Freilinghaus, Monika and Kocmit, A. and Bork, Hans-Rudolf and Schmidt, R.},
  title     = {Tolerierbarer Bodenabtrag : Grenzen seiner Anwendbarkeit},
  year      = {1998},
  language  = {de}
}
@article{LauchtEsserSchmidtetal.1996,
  author    = {Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H. and St{\"o}hr, R.-M. and Weindrich, D. and Ihle, Wolfgang and Marcus, A.},
  title     = {Viereinhalb Jahre danach : Mannheimer Risikokinder im Vorschulalter},
  year      = {1996},
  language  = {de}
}
@article{GruberChakravartyBaehtzetal.2011,
  author    = {Gruber, W. and Chakravarty, S. and Baehtz, C. and Leitenberger, Wolfram and Bruns, M. and Kobler, A. and K{\"u}bel, Christian and Schmidt, H.},
  title     = {Strain relaxation and vacancy creation in thin platinum films},
  series = {Physical review letters},
  volume    = {107},
  journal   = {Physical review letters},
  number    = {26},
  publisher = {American Physical Society},
  address   = {College Park},
  issn      = {0031-9007},
  doi       = {10.1103/PhysRevLett.107.265501},
  pages     = {5},
  year      = {2011},
  abstract  = {Synchrotron based combined in situ x-ray diffractometry and reflectometry is used to investigate the role of vacancies for the relaxation of residual stress in thin metallic Pt films. From the experimentally determined relative changes of the lattice parameter a and of the film thickness L the modification of vacancy concentration and residual strain was derived as a function of annealing time at 130 degrees C. The results indicate that relaxation of strain resulting from compressive stress is accompanied by the creation of vacancies at the free film surface. This proves experimentally the postulated dominant role of vacancies for stress relaxation in thin metal films close to room temperature.},
  language  = {en}
}
@misc{SachseBillaultBowenetal.2012,
  author    = {Sachse, Dirk and Billault, Isabelle and Bowen, Gabriel J. and Chikaraishi, Yoshito and Dawson, Todd E. and Feakins, Sarah J. and Freeman, Katherine H. and Magill, Clayton R. and McInerney, Francesca A. and van der Meer, Marcel T. J. and Polissar, Pratigya and Robins, Richard J. and Sachs, Julian P. and Schmidt, Hanns-Ludwig and Sessions, Alex L. and White, James W. C. and West, Jason B. and Kahmen, Ansgar},
  title     = {Molecular Paleohydrology interpreting the Hydrogen- Isotopic Composition of Lipid Biomarkers from Photosynthesizing Organisms},
  series = {Annual review of earth and planetary sciences},
  volume    = {40},
  journal   = {Annual review of earth and planetary sciences},
  number    = {1},
  editor    = {Jeanloz, R},
  publisher = {Annual Reviews},
  address   = {Palo Alto},
  isbn      = {978-0-8243-2040-9},
  issn      = {0084-6597},
  doi       = {10.1146/annurev-earth-042711-105535},
  pages     = {221 -- 249},
  year      = {2012},
  abstract  = {Hydrogen-isotopic abundances of lipid biomarkers are emerging as important proxies in the study of ancient environments and ecosystems. A decade ago, pioneering studies made use of new analytical methods and demonstrated that the hydrogen-isotopic composition of individual lipids from aquatic and terrestrial organisms can be related to the composition of their growth (i.e., environmental) water. Subsequently, compound-specific deuterium/hydrogen (D/H) ratios of sedimentary biomarkers have been increasingly used as paleohydrological proxies over a range of geological timescales. Isotopic fractionation observed between hydrogen in environmental water and hydrogen in lipids, however, is sensitive to biochemical, physiological, and environmental influences on the composition of hydrogen available for biosynthesis in cells. Here we review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids-especially n-alkanes-from photosynthesizing organisms, and we provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities.},
  language  = {en}
}
@article{EllisBlandHawthornLawrenceetal.2012,
  author    = {Ellis, S. C. and Bland-Hawthorn, Joss and Lawrence, J. and Horton, A. J. and Trinh, C. and Leon-Saval, S. G. and Shortridge, K. and Bryant, J. and Case, S. and Colless, M. and Couch, W. and Freeman, K. and Gers, L. and Glazebrook, K. and Haynes, R. and Lee, S. and L{\"o}hmannsr{\"o}ben, Hans-Gerd and O'Byrne, J. and Miziarski, S. and Roth, M. and Schmidt, B. and Tinney, C. G. and Zheng, J.},
  title     = {Suppression of the near-infrared OH night-sky lines with fibre Bragg gratings - first results},
  series = {Monthly notices of the Royal Astronomical Society},
  volume    = {425},
  journal   = {Monthly notices of the Royal Astronomical Society},
  number    = {3},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0035-8711},
  doi       = {10.1111/j.1365-2966.2012.21602.x},
  pages     = {1682 -- 1695},
  year      = {2012},
  abstract  = {The background noise between 1 and 1.8 ?mu m in ground-based instruments is dominated by atmospheric emission from hydroxyl molecules. We have built and commissioned a new instrument, the Gemini Near-infrared OH Suppression Integral Field Unit (IFU) System (GNOSIS), which suppresses 103 OH doublets between 1.47 and 1.7?mu m by a factor of 1000 with a resolving power of 10?000. We present the first results from the commissioning of GNOSIS using the IRIS2 spectrograph at the Anglo-Australian Telescope. We present measurements of sensitivity, background and throughput. The combined throughput of the GNOSIS fore-optics, grating unit and relay optics is 36?per cent, but this could be improved to 46?per cent with a more optimal design. We measure strong suppression of the OH lines, confirming that OH suppression with fibre Bragg gratings will be a powerful technology for low-resolution spectroscopy. The integrated OH suppressed background between 1.5 and 1.7 mu m is reduced by a factor of 9 compared to a control spectrum using the same system without suppression. The potential of low-resolution OH-suppressed spectroscopy is illustrated with example observations of Seyfert galaxies and a low-mass star. The GNOSIS background is dominated by detector dark current below 1.67 mu m and by thermal emission above 1.67 mu m. After subtracting these, we detect an unidentified residual interline component of 860 +/- 210 photons s-1 m-2?arcsec-2?mu m-1, comparable to previous measurements. This component is equally bright in the suppressed and control spectra. We have investigated the possible source of the interline component, but were unable to discriminate between a possible instrumental artefact and intrinsic atmospheric emission. Resolving the source of this emission is crucial for the design of fully optimized OH suppression spectrographs. The next-generation OH suppression spectrograph will be focused on resolving the source of the interline component, taking advantage of better optimization for a fibre Bragg grating feed incorporating refinements of design based on our findings from GNOSIS. We quantify the necessary improvements for an optimal OH suppressing fibre spectrograph design.},
  language  = {en}
}
@article{SchmidtKundicPenetal.2002,
  author    = {Schmidt, Robert W. and Kundic, T. and Pen, U.-L. and Wambsganß, Joachim and Bergeron, L. E. and Colley, W. and Corson, C. and Hastings, N. G. and Hoyes, T. and Long, D. C. and Loomis, K. A. and Malhotra, S. and Rhoads, J. E. and Stanek, K. Z.},
  title     = {Optical monitoring of the gravitationally lensed quasar Q2237+0305 from APO between June 1995 and January 1998},
  year      = {2002},
  abstract  = {We present a data set of images of the gravitationally lensed quasar Q2237+0305, that was obtained at the Apache Point Observatory (APO) between June 1995 and January 1998. Although the images were taken under variable, often poor seeing conditions and with coarse pixel sampling, photometry is possible for the two brighter quasar images A and B with the help of exact quasar image positions from HST observations. We obtain a light curve with 73 data points for each of the images A and B. There is evidence for a long (ga 100 day) brightness peak in image A in 1996 with an amplitude of about 0.4 to 0.5 mag (relative to 1995), which indicates that microlensing has been taking place in the lensing galaxy. Image B does not vary much over the course of the observation period. The long, smooth variation of the light curve is similar to the results from the OGLE monitoring of the system (Wozniak et al. cite{Wozniak00}). Based on observations obtained with the Apache Point Observatory 3.5-meter telescope, which is owned and operated by the Astrophysical Research Consortium.},
  language  = {en}
}
@article{SturzbecherWelskopfSchmidtButhenhoff2000,
  author    = {Sturzbecher, Dietmar and Welskopf, R. and Schmidt-Buthenhoff, A.},
  title     = {Welche Bildungsangebote w{\"u}nschen sich Sch{\"u}ler zum Thema Antisemitismus},
  isbn      = {3-8017-1169-2},
  year      = {2000},
  language  = {de}
}
@book{MientusKlempinNowaketal.2023,
  author    = {Mientus, Lukas and Klempin, Christiane and Nowak, Anna and Wyss, Corinne and Aufschnaiter, Claudia von and Faix, Ann-Christin and te Poel, Kathrin and Wahbe, Nadia and Pieper, Martin and H{\"o}ller, Katharina and Kallenbach, Lea and F{\"o}rster, Magdalena and Redecker, Anke and Dick, Mirjam and Holle, J{\"o}rg and Schneider, Edina and Rehfeldt, Daniel and Brauns, Sarah and Abels, Simone and Ferencik-Lehmkuhl, Daria and Fr{\"a}nkel, Silvia and Frohn, Julia and Liebsch, Ann-Catherine and Pech, Detlef and Schreier, Pascal and Jessen, Moiken and Großmann, Uta and Skintey, Lesya and Voerkel, Paul and Vaz Ferreira, Mergenfel A. and Zimmermann, Jan-Simon and Buddeberg, Magdalena and Henke, Vanessa and Hornberg, Sabine and V{\"o}lschow, Yvette and Warrelmann, Julia-Nadine and Malek, Jennifer and Tinnefeld, Anja and Schmidt, Peggy and Bauer, Tobias and J{\"a}nisch, Christopher and Spitzer, Lisa and Franken, Nadine and Degeling, Maria and Preisfeld, Angelika and Meier, Jana and K{\"u}th, Simon and Scholl, Daniel and Vogelsang, Christoph and Watson, Christina and Weißbach, Anna and Kulgemeyer, Christoph and Oetken, Mandy and Gorski, Sebastian and Kubsch, Marcus and Sorge, Stefan and Wulff, Peter and Fellenz, Carolin D. and Schnell, Susanne and Larisch, Cathleen and Kaiser, Franz and Knott, Christina and Reimer, Stefanie and Stegm{\"u}ller, Nathalie and Boukray{\^a}a Trabelsi, Kathrin and Schißlbauer, Franziska and Lemberger, Lukas and Barth, Ulrike and Wiehl, Angelika and Rogge, Tim and B{\"o}hnke, Anja and Dietz, Dennis and Großmann, Leroy and Wienmeister, Annett and Zoppke, Till and Jiang, Lisa and Gr{\"u}nbauer, Stephanie and Ostersehlt, D{\"o}rte and Peukert, Sophia and Sch{\"a}fer, Christoph and L{\"o}big, Anna and Br{\"o}ll, Leena and Brandt, Birgit and Breuer, Meike and Dausend, Henriette and Krelle, Michael and Andersen, Gesine and Falke, Sascha and Kindermann-G{\"u}zel, Kristin and K{\"o}rner, Katrina and Lottermoser, Lisa-Marie and P{\"u}gner, Kati and Sonnenburg, Nadine and Akarsu, Selim and Rechl, Friederike and Gadinger, Laureen and Heinze, Lena and Wittmann, Eveline and Franke, Manuela and Lachmund, Anne-Marie and B{\"o}ttger, Julia and Hannover, Bettina and Behrendt, Renata and Conty, Valentina and Grundmann, Stephanie and Ghassemi, Novid and Opitz, Ben and Br{\"a}mer, Martin and Gasparjan, David and Sambanis, Michaela and K{\"o}ster, Hilde and L{\"u}cke, Martin and Nordmeier, Volkhard and Schaal, Sonja and Haberbosch, Maximilian and Meissner, Maren and Schaal, Steffen and Br{\"u}chner, Melanie and Riehle, Tamara and Leopold, Bengta Marie and Gerlach, Susanne and Rau-Patschke, Sarah and Skorsetz, Nina and Weber, Nadine and Damk{\"o}hler, Jens and Elsholz, Markus and Trefzger, Thomas and Lewek, Tobias and Borowski, Andreas},
  title     = {Reflexion in der Lehrkr{\"a}ftebildung},
  series = {Potsdamer Beitr{\"a}ge f{\"u}r Lehrkr{\"a}ftebildung und Bildungsforschung},
  journal   = {Potsdamer Beitr{\"a}ge f{\"u}r Lehrkr{\"a}ftebildung und Bildungsforschung},
  number    = {4},
  editor    = {Mientus, Lukas and Klempin, Christiane and Nowak, Anna},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-566-8},
  issn      = {2626-3556},
  doi       = {10.25932/publishup-59171},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-591717},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {452},
  year      = {2023},
  abstract  = {Reflexion ist eine Schl{\"u}sselkategorie f{\"u}r die professionelle Entwicklung von Lehrkr{\"a}ften, welche als Ausbildungsziel in den Bildungsstandards f{\"u}r die Lehrkr{\"a}ftebildung verankert ist. Eine Verstetigung universit{\"a}r gepr{\"a}gter Forschung und Modellierung in der praxisnahen Anwendung im schulischen Kontext bietet Potentiale nachhaltiger Professionalisierung. Die St{\"a}rkung reflexionsbezogener Kompetenzen durch Empirie und Anwendung scheint eine phasen{\"u}bergreifende Herausforderung der Lehrkr{\"a}ftebildung zu sein, die es zu bew{\"a}ltigen gilt. Ziele des Tagungsbandes Reflexion in der Lehrkr{\"a}ftebildung sind eine theoretische Sch{\"a}rfung des Konzeptes „Reflexive Professionalisierung" und der Austausch {\"u}ber Fragen der Einbettung wirksamer reflexionsbezogener Lerngelegenheiten in die Lehrkr{\"a}ftebildung. Forschende und Lehrende der‚ drei Phasen (Studium, Referendariat sowie Fort- und Weiterbildung) der Lehrkr{\"a}ftebildung stellen Lehrkonzepte und Forschungsprojekte zum Thema Reflexion in der Lehrkr{\"a}ftebildung vor und diskutieren diese. Gemeinsam mit Teilnehmenden aller Phasen und von verschiedenen Standorten der Lehrkr{\"a}ftebildung werden zuk{\"u}nftige Herausforderungen identifiziert und L{\"o}sungsans{\"a}tze herausgearbeitet.},
  language  = {de}
}
@article{FargesDjanarthanydeWispelaereetal.2005,
  author    = {Farges, Francois and Djanarthany, S and de Wispelaere, S and Munoz, Manuel and Magassouba, B and Haddi, A and Wilke, Max and Schmidt, C. and Borchert, Manuela and Trocellier, P and Crichton, W and Simionovici, Alexandre and Petit, Pierre-Emanuel and Mezouar, Mohamed and Etcheverry, M. P. and Pallot-Frossard, I and Bargar, John Reeder and Brown, G. E. and Grolimund, D and Scheidegger, A},
  title     = {Water in silicate glasses and melts of environmental interest : from volcanoes to cathedrals},
  year      = {2005},
  abstract  = {In silicate glasses and melts, water acts according to two main processes. First, it can be dissolved in high temperature/high pressure melts. Second, it constitutes a weathering agent on the glass surface. A number of in-situ x- ray absorption fine structure (XAFS) studies for Fe, Ni, Zr, Th and U show that the more charged cations (Zr, Nb, Mo, Ta, Sn, Th and U) are little affected by the presence of dissolved water in the melt. In contrast, divalent iron and nickel are highly sensitive to the presence of water, which enhance nucleation processes, for example, of phyllosilicates at the angstrom-scale. Such information provides additional constraints on the role of water deep in the Earth, particularly in magmatology. By contrast, the weathering of glass surfaces by water can be studied from a durability perspective. Experimental weathering experiments Of nuclear waste glasses performed in the laboratory show a variety of surface enrichments (carbon, chlorine, alkalis, iron) after exposure to atmospheric fluids and moisture. Mn-, and Fe-surface enrichments of analogous glasses of the XIVth century are related to the formation of Mn and Fe oxy/ hydroxides on the surface. The impact on the glass darkening is considered in terms of urban pollution and mass tourism},
  language  = {en}
}
@article{FilimonKopfBalloutetal.2010,
  author    = {Filimon, Marlena and Kopf, Ilona and Ballout, Fuad and Schmidt, Dietrich A. and Bruendermann, Erik and R{\"u}he, J{\"u}rgen and Santer, Svetlana and Havenith, Martina},
  title     = {Smart polymer surfaces : mapping chemical landscapes on the nanometre scale},
  issn      = {1744-683X},
  doi       = {10.1039/C0sm00098a},
  year      = {2010},
  abstract  = {We show that Scattering Infrared Near-field Microscopy (SNIM) allows chemical mapping of polymer monolayers that can serve as designed nanostructured surfaces with specific surface chemistry properties on a nm scale. Using s- SNIM a minimum volume of 100 nm x 100 nm x 15 nm is sufficient for a recording of a "chemical'' IR signature which corresponds to an enhancement of at least four orders of magnitudes compared to conventional FT-IR microscopy. We could prove that even in cases where it is essentially difficult to distinguish between distinct polymer compositions based solely on topography, nanophase separated polymers can be clearly distinguished according to their characteristic near-field IR response.},
  language  = {en}
}
@article{FilimonKopfSchmidtetal.2011,
  author    = {Filimon, Marlena and Kopf, Ilona and Schmidt, Dietrich A. and Bruendermann, Erik and R{\"u}he, J{\"u}rgen and Santer, Svetlana and Havenith, Martina},
  title     = {Local chemical composition of nanophase-separated polymer brushes},
  series = {Physical chemistry, chemical physics : a journal of European Chemical Societies},
  volume    = {13},
  journal   = {Physical chemistry, chemical physics : a journal of European Chemical Societies},
  number    = {24},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1463-9076},
  doi       = {10.1039/c0cp02756a},
  pages     = {11620 -- 11626},
  year      = {2011},
  abstract  = {Using scattering scanning nearfield infrared microscopy (s-SNIM), we have imaged the nanoscale phase separation of mixed polystyrene-poly(methyl methacrylate) (PS-PMMA) brushes and investigated changes in the top layer as a function of solvent exposure. We deduce that the top-layer of the mixed brushes is composed primarily of PMMA after exposure to acetone, while after exposure to toluene this changes to PS. Access to simultaneously measured topographic and chemical information allows direct correlation of the chemical morphology of the sample with topographic information. Our results demonstrate the potential of s-SNIM for chemical mapping based on distinct infrared absorption properties of polymers with a high spatial resolution of 80 nm x 80 nm.},
  language  = {en}
}
@article{DebatinBehrensWeberetal.2012,
  author    = {Debatin, Franziska and Behrens, Karsten and Weber, Jens and Baburin, Igor A. and Thomas, Arne and Schmidt, Johannes and Senkovska, Irena and Kaskel, Stefan and Kelling, Alexandra and Hedin, Niklas and Bacsik, Zoltan and Leoni, Stefano and Seifert, Gotthard and J{\"a}ger, Christian and G{\"u}nter, Christina and Schilde, Uwe and Friedrich, Alwin and Holdt, Hans-J{\"u}rgen},
  title     = {An isoreticular family of microporous metal-organic frameworks based on zinc and 2-substituted imidazolate-4-amide-5-imidate Syntheses, structures and properties},
  series = {Chemistry - a European journal},
  volume    = {18},
  journal   = {Chemistry - a European journal},
  number    = {37},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0947-6539},
  doi       = {10.1002/chem.201200889},
  pages     = {11630 -- 11640},
  year      = {2012},
  abstract  = {We report on a new series of isoreticular frameworks based on zinc and 2-substituted imidazolate-4-amide-5-imidate (IFP-14, IFP=imidazolate framework Potsdam) that form one-dimensional, microporous hexagonal channels. Varying R in the 2-substitued linker (R=Me (IFP-1), Cl (IFP-2), Br (IFP-3), Et (IFP-4)) allowed the channel diameter (4.01.7 angstrom), the polarisability and functionality of the channel walls to be tuned. Frameworks IFP-2, IFP-3 and IFP-4 are isostructural to previously reported IFP-1. The structures of IFP-2 and IFP-3 were solved by X-ray crystallographic analyses. The structure of IFP-4 was determined by a combination of PXRD and structure modelling and was confirmed by IR spectroscopy and 1H MAS and 13C CP-MAS NMR spectroscopy. All IFPs showed high thermal stability (345400?degrees C); IFP-1 and IFP-4 were stable in boiling water for 7 d. A detailed porosity analysis was performed on the basis of adsorption measurements by using various gases. The potential of the materials to undergo specific interactions with CO2 was investigated by measuring the isosteric heats of adsorption. The capacity to adsorb CH4 (at 298 K), CO2 (at 298 K) and H2 (at 77 K) at high pressure were also investigated. In situ IR spectroscopy showed that CO2 is physisorbed on IFP-14 under dry conditions and that both CO2 and H2O are physisorbed on IFP-1 under moist conditions.},
  language  = {en}
}
@misc{DinerKrahRabinetal.2021,
  author    = {Diner, Hasia and Krah, Markus and Rabin, Shari and Schwartz, Yitzchak and Thulin, Mirjam and Czendze, Oskar and Schmidt, Imanuel Clemens and Cooperman, Jessica and Gallas, Elisabeth and R{\"u}rup, Miriam and Heyde, J{\"u}rgen and Meyer, Thomas and Ries, Rotraud and Ullrich, Anna and Geißler-Gr{\"u}nberg, Anke and Schulz, Michael Karl and Arnold, Rafael D. and Sinn, Andrea A.},
  title     = {PaRDeS : Journal of the Association for Jewish Studies in Germany = Foreign Entanglements: Transnational American Jewish Studies},
  series = {PaRDeS : Journal of the Association for Jewish Studies in Germany},
  journal   = {PaRDeS : Journal of the Association for Jewish Studies in Germany},
  number    = {27},
  editor    = {Diner, Hasia and Krah, Markus and Siegel, Bj{\"o}rn},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-520-0},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-51933},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-519333},
  pages     = {189},
  year      = {2021},
  abstract  = {The field of American Jewish studies has recently trained its focus on the transnational dimensions of its subject, reflecting in more sustained ways than before about the theories and methods of this approach. Yet, much of the insight to be gained from seeing American Jewry as constitutively entangled in many ways with other Jewries has not yet been realized. Transnational American Jewish studies are still in their infancy. This issue of PaRDeS presents current research on the multiple entanglements of American with Central European, especially German-speaking Jewries in the 19th and 20th centuries. The articles reflect the wide range of topics that can benefit from a transnational understanding of the American Jewish experience as shaped by its foreign entanglements.},
  language  = {en}
}
@article{FoersterBullLenzetal.2018,
  author    = {F{\"o}rster, Daniel W. and Bull, James K. and Lenz, Dorina and Autenrieth, Marijke and Paijmans, Johanna L. A. and Kraus, Robert H. S. and Nowak, Carsten and Bayerl, Helmut and K{\"u}hn, Ralph and Saveljev, Alexander P. and Sindicic, Magda and Hofreiter, Michael and Schmidt, Krzysztof and Fickel, J{\"o}rns},
  title     = {Targeted resequencing of coding DNA sequences for SNP discovery in nonmodel species},
  series = {Molecular ecology resources},
  volume    = {18},
  journal   = {Molecular ecology resources},
  number    = {6},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1755-098X},
  doi       = {10.1111/1755-0998.12924},
  pages     = {1356 -- 1373},
  year      = {2018},
  abstract  = {Targeted capture coupled with high-throughput sequencing can be used to gain information about nuclear sequence variation at hundreds to thousands of loci. Divergent reference capture makes use of molecular data of one species to enrich target loci in other (related) species. This is particularly valuable for nonmodel organisms, for which often no a priori knowledge exists regarding these loci. Here, we have used targeted capture to obtain data for 809 nuclear coding DNA sequences (CDS) in a nonmodel organism, the Eurasian lynx Lynx lynx, using baits designed with the help of the published genome of a related model organism (the domestic cat Felis catus). Using this approach, we were able to survey intraspecific variation at hundreds of nuclear loci in L. lynx across the species' European range. A large set of biallelic candidate SNPs was then evaluated using a high-throughput SNP genotyping platform (Fluidigm), which we then reduced to a final 96 SNP-panel based on assay performance and reliability; validation was carried out with 100 additional Eurasian lynx samples not included in the SNP discovery phase. The 96 SNP-panel developed from CDS performed very successfully in the identification of individuals and in population genetic structure inference (including the assignment of individuals to their source population). In keeping with recent studies, our results show that genic SNPs can be valuable for genetic monitoring of wildlife species.},
  language  = {en}
}
@article{JesusSchmidtFickeletal.2022,
  author    = {Jesus, Sonia A. and Schmidt, Anke and Fickel, J{\"o}rns and Doherr, Marcus G. and Boonprasert, Khajohnpat and Thitaram, Chatchote and Sariya, Ladawan and Ratanakron, Parntep and Hildebrandt, Thomas Bernd},
  title     = {Assessing coagulation parameters in healthy Asian Elephants (Elephas maximus) from European and thai populations},
  series = {Animals},
  volume    = {12},
  journal   = {Animals},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2076-2615},
  doi       = {10.3390/ani12030361},
  pages     = {16},
  year      = {2022},
  abstract  = {Simple Summary Asian elephants (Elephas maximus) are considered endangered and their population is in continuous decline. Understanding their social interactions, health, and welfare status has been a topic of intense research in recent decades. Coagulation assessments have been underutilized in wildlife but can give valuable information on individual health. This study aims to increase the knowledge of the coagulation status in healthy Asian elephants from different backgrounds and age groups, using a fast point-of-care analyzer. This tool can be further used in either routine health check-ups performed by caretakers or in a clinical emergency, such as in cases of elephant endotheliotropic herpesvirus hemorrhagic disease outbreaks. We have also investigated the presence of genomic mutations in one coagulation factor-factor VII-where a disorder was previously reported in an Asian elephant. Hereby, we report new reference values for coagulation parameters, such as coagulation times and fibrinogen concentration of Asian elephants assessed in Thailand and in Europe, as well as several single point mutations found in the exons of Elephas maximus coagulation F7 gene. We found the point-of-care analyzer used in this study to be very practical and user friendly for a zoo and field environment and hope that this project will incentivize further coagulation studies in Asian elephants and in other wildlife species. The Asian elephant population is continuously declining due to several extrinsic reasons in their range countries, but also due to diseases in captive populations worldwide. One of these diseases, the elephant endotheliotropic herpesvirus (EEHV) hemorrhagic disease, is very impactful because it particularly affects Asian elephant calves. It is commonly fatal and presents as an acute and generalized hemorrhagic syndrome. Therefore, having reference values of coagulation parameters, and obtaining such values for diseased animals in a very short time, is of great importance. We analyzed prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen concentrations using a portable and fast point-of-care analyzer (VetScan Pro) in 127 Asian elephants from Thai camps and European captive herds. We found significantly different PT and aPTT coagulation times between elephants from the two regions, as well as clear differences in fibrinogen concentration. Nevertheless, these alterations were not expected to have biological or clinical implications. We have also sequenced the coagulation factor VII gene of 141 animals to assess the presence of a previously reported hereditary coagulation disorder in Asian elephants and to investigate the presence of other mutations. We did not find the previously reported mutation in our study population. Instead, we discovered the presence of several new single nucleotide polymorphisms, two of them being considered as deleterious by effect prediction software.},
  language  = {en}
}
@article{KlemmeFeldhausPotapkinetal.2021,
  author    = {Klemme, Stephan and Feldhaus, Michael and Potapkin, Vasily and Wilke, Max and Borchert, Manuela and Louvel, Marion and Loges, Anselm and Rohrbach, Arno and Weitkamp, Petra and Welter, Edmund and Kokh, Maria A. and Schmidt, Christian and Testemale, Denis},
  title     = {A hydrothermal apparatus for x-ray absorption spectroscopy of hydrothermal fluids at DESY},
  series = {Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques},
  volume    = {92},
  journal   = {Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques},
  number    = {6},
  publisher = {AIP Publishing},
  address   = {Melville},
  issn      = {0034-6748},
  doi       = {10.1063/5.0044767},
  pages     = {6},
  year      = {2021},
  abstract  = {We present a new autoclave that enables in situ characterization of hydrothermal fluids at high pressures and high temperatures at synchrotron x-ray radiation sources. The autoclave has been specifically designed to enable x-ray absorption spectroscopy in fluids with applications to mineral solubility and element speciation analysis in hydrothermal fluids in complex compositions. However, other applications, such as Raman spectroscopy, in high-pressure fluids are also possible with the autoclave. First experiments were run at pressures between 100 and 600 bars and at temperatures between 25 degrees C and 550 degrees C, and preliminary results on scheelite dissolution in fluids of different compositions show that the autoclave is well suited to study the behavior of ore-forming metals at P-T conditions relevant to the Earth's crust.},
  language  = {en}
}
@article{BernhardMoskwaSchmidtetal.2018,
  author    = {Bernhard, Nadine and Moskwa, Lisa-Marie and Schmidt, Karsten and Oeser, Ralf Andreas and Aburto, Felipe and Bader, Maaike Y. and Baumann, Karen and von Blanckenburg, Friedhelm and Boy, Jens and van den Brink, Liesbeth and Brucker, Emanuel and Buedel, Burkhard and Canessa, Rafaella and Dippold, Michaela A. and Ehlers, Todd and Fuentes, Juan P. and Godoy, Roberto and Jung, Patrick and Karsten, Ulf and Koester, Moritz and Kuzyakov, Yakov and Leinweber, Peter and Neidhardt, Harald and Matus, Francisco and Mueller, Carsten W. and Oelmann, Yvonne and Oses, Romulo and Osses, Pablo and Paulino, Leandro and Samolov, Elena and Schaller, Mirjam and Schmid, Manuel and Spielvogel, Sandra and Spohn, Marie and Stock, Svenja and Stroncik, Nicole and Tielboerger, Katja and Uebernickel, Kirstin and Scholten, Thomas and Seguel, Oscar and Wagner, Dirk and K{\"u}hn, Peter},
  title     = {Pedogenic and microbial interrelations to regional climate and local topography},
  series = {Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution},
  volume    = {170},
  journal   = {Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0341-8162},
  doi       = {10.1016/j.catena.2018.06.018},
  pages     = {335 -- 355},
  year      = {2018},
  abstract  = {The effects of climate and topography on soil physico-chemical and microbial parameters were studied along an extensive latitudinal climate gradient in the Coastal Cordillera of Chile (26 degrees-38 degrees S). The study sites encompass arid (Pan de Azucar), semiarid (Santa Gracia), mediterranean (La Campana) and humid (Nahuelbuta) climates and vegetation, ranging from arid desert, dominated by biological soil crusts (biocrusts), semiarid shrubland and mediterranean sclerophyllous forest, where biocrusts are present but do have a seasonal pattern to temperate-mixed forest, where biocrusts only occur as an early pioneering development stage after disturbance. All soils originate from granitic parent materials and show very strong differences in pedogenesis intensity and soil depth. Most of the investigated physical, chemical and microbiological soil properties showed distinct trends along the climate gradient. Further, abrupt changes between the arid northernmost study site and the other semi-arid to humid sites can be shown, which indicate non-linearity and thresholds along the climate gradient. Clay and total organic carbon contents (TOC) as well as Ah horizons and solum depths increased from arid to humid climates, whereas bulk density (BD), pH values and base saturation (BS) decreased. These properties demonstrate the accumulation of organic matter, clay formation and element leaching as key-pedogenic processes with increasing humidity. However, the soils in the northern arid climate do not follow this overall latitudinal trend, because texture and BD are largely controlled by aeolian input of dust and sea salts spray followed by the formation of secondary evaporate minerals. Total soil DNA concentrations and TOC increased from arid to humid sites, while areal coverage by biocrusts exhibited an opposite trend. Relative bacterial and archaeal abundances were lower in the arid site, but for the other sites the local variability exceeds the variability along the climate gradient. Differences in soil properties between topographic positions were most pronounced at the study sites with the mediterranean and humid climate, whereas microbial abundances were independent on topography across all study sites. In general, the regional climate is the strongest controlling factor for pedogenesis and microbial parameters in soils developed from the same parent material. Topographic position along individual slopes of limited length augmented this effect only under humid conditions, where water erosion likely relocated particles and elements downward. The change from alkaline to neutral soil pH between the arid and the semi-arid site coincided with qualitative differences in soil formation as well as microbial habitats. This also reflects non-linear relationships of pedogenic and microbial processes in soils depending on climate with a sharp threshold between arid and semi-arid conditions. Therefore, the soils on the transition between arid and semi-arid conditions are especially sensitive and may be well used as indicators of long and medium-term climate changes. Concluding, the unique latitudinal precipitation gradient in the Coastal Cordillera of Chile is predestined to investigate the effects of the main soil forming factor - climate - on pedogenic processes.},
  language  = {en}
}
@misc{MuellerSchoellKloppSchulzeHuisingaetal.2019,
  author    = {M{\"u}ller-Sch{\"o}ll, A. and Klopp-Schulze, Lena and Huisinga, Wilhelm and J{\"o}rger, M. and Neven, P. and Koolen, S. L. and Mathijssen, R. H. J. and Schmidt, S. and Kloft, Charlotte},
  title     = {Patient-tailored tamoxifen dosing based on an increased quantitative understanding of its complex pharmacokinetics: A novel integrative modelling approach},
  series = {Annals of Oncology},
  volume    = {30},
  journal   = {Annals of Oncology},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0923-7534},
  pages     = {1},
  year      = {2019},
  language  = {en}
}
@misc{JeglinskiMendeSchmidt2021,
  author    = {Jeglinski-Mende, Melinda A. and Schmidt, Hendrikje},
  title     = {Psychotherapy in the Framework of Embodied Cognition},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {708},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-50316},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-503162},
  pages     = {11},
  year      = {2021},
  abstract  = {Mental health problems remain among the main generators of costs within and beyond the health care system. Psychotherapy, the tool of choice in their treatment, is qualified by social interaction, and cooperation within the therapist-patient-dyad. Research into the factors influencing therapy success to date is neither exhaustive nor conclusive. Among many others, the quality of the relationship between therapist and patient stands out regardless of the followed psychotherapy school. Emerging research points to a connection between interpersonal synchronization within the sessions and therapy outcome. Consequently, it can be considered significant for the shaping of this relationship. The framework of Embodied Cognition assumes bodily and neuronal correlates of thinking. Therefore, the present paper reviews investigations on interpersonal, non-verbal synchrony in two domains: firstly, studies on interpersonal synchrony in psychotherapy are reviewed (synchronization of movement). Secondly, findings on neurological correlates of interpersonal synchrony (assessed with EEG, fMRI, fNIRS) are summarized in a narrative manner. In addition, the question is asked whether interpersonal synchrony can be achieved voluntarily on an individual level. It is concluded that there might be mechanisms which could give more insights into therapy success, but as of yet remain uninvestigated. Further, the framework of embodied cognition applies more to the current body of evidence than classical cognitivist views. Nevertheless, deeper research into interpersonal physical and neurological processes utilizing the framework of Embodied Cognition emerges as a possible route of investigation on the road to lower drop-out rates, improved and quality-controlled therapeutic interventions, thereby significantly reducing healthcare costs.},
  language  = {en}
}
@article{JeglinskiMendeSchmidt2021,
  author    = {Jeglinski-Mende, Melinda A. and Schmidt, Hendrikje},
  title     = {Psychotherapy in the Framework of Embodied Cognition},
  series = {Frontiers in Psychiatry},
  volume    = {12},
  journal   = {Frontiers in Psychiatry},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-0640},
  doi       = {10.3389/fpsyt.2021.562490},
  pages     = {9},
  year      = {2021},
  abstract  = {Mental health problems remain among the main generators of costs within and beyond the health care system. Psychotherapy, the tool of choice in their treatment, is qualified by social interaction, and cooperation within the therapist-patient-dyad. Research into the factors influencing therapy success to date is neither exhaustive nor conclusive. Among many others, the quality of the relationship between therapist and patient stands out regardless of the followed psychotherapy school. Emerging research points to a connection between interpersonal synchronization within the sessions and therapy outcome. Consequently, it can be considered significant for the shaping of this relationship. The framework of Embodied Cognition assumes bodily and neuronal correlates of thinking. Therefore, the present paper reviews investigations on interpersonal, non-verbal synchrony in two domains: firstly, studies on interpersonal synchrony in psychotherapy are reviewed (synchronization of movement). Secondly, findings on neurological correlates of interpersonal synchrony (assessed with EEG, fMRI, fNIRS) are summarized in a narrative manner. In addition, the question is asked whether interpersonal synchrony can be achieved voluntarily on an individual level. It is concluded that there might be mechanisms which could give more insights into therapy success, but as of yet remain uninvestigated. Further, the framework of embodied cognition applies more to the current body of evidence than classical cognitivist views. Nevertheless, deeper research into interpersonal physical and neurological processes utilizing the framework of Embodied Cognition emerges as a possible route of investigation on the road to lower drop-out rates, improved and quality-controlled therapeutic interventions, thereby significantly reducing healthcare costs.},
  language  = {en}
}
@article{WojcinskiCasselFarrokhetal.2012,
  author    = {Wojcinski, Sebastian and Cassel, Michael and Farrokh, Andre and Soliman, Amr A. and Hille, Ursula and Schmidt, Werner and Degenhardt, Friedrich and Hillemanns, Peter},
  title     = {Variations in the elasticity of breast tissue during the menstrual cycle determined by real-time sonoelastography},
  series = {Journal of ultrasound in medicine},
  volume    = {31},
  journal   = {Journal of ultrasound in medicine},
  number    = {1},
  publisher = {American Institute of Ultrasound in Medicine},
  address   = {Laurel},
  issn      = {0278-4297},
  pages     = {63 -- 72},
  year      = {2012},
  abstract  = {Objectives-The purpose of this study was to determine the dependence of breast tissue elasticity on the menstrual cycle of healthy volunteers by means of real-time sonoelastography. Methods-Twenty-two healthy volunteers (aged 18-33 years) were examined once weekly during two consecutive menstrual cycles using sonoelastography. Group 1 (n = 10) was not taking hormonal medication; group 2 (n = 12) was taking oral contraceptives. Results-The breast parenchyma appeared softer than the dermis and harder than the adipose tissue, and elasticity varied over the menstrual cycle and between groups. Group 1 (no hormone intake) showed continuously increasing elasticity with relatively soft breast parenchyma in the menstrual and follicular phases and harder parenchyma in the luteal phase (P = .012). Group 2 (oral contraceptives) showed no statistically significant changes in breast parenchymal elasticity according to sonoelastography. The parenchyma was generally softer in group 1 compared with group 2 throughout the menstrual cycle (P = .033). The dermis, the subcutaneous adipose tissue, and the pectoralis major muscle showed no changes in elasticity. Comparison of measurements made during the first and the second menstrual cycles showed similar patterns of elasticity in both groups. Conclusions-Sonoelastography is a reproducible method that can be used to determine the dependence of breast parenchyma elasticity on the menstrual cycle and on the intake of hormonal contraceptives.},
  language  = {en}
}
@misc{vanReesWaylenSchmidtKloiberetal.2020,
  author    = {van Rees, Charles B. and Waylen, Kerry A. and Schmidt-Kloiber, Astrid and Thackeray, Stephen J. and Kalinkat, Gregor and Martens, Koen and Domisch, Sami and Lillebo, Ana and Hermoso, Virgilio and Grossart, Hans-Peter and Schinegger, Rafaela and Decleer, Kris and Adriaens, Tim and Denys, Luc and Jaric, Ivan and Janse, Jan H. and Monaghan, Michael T. and De Wever, Aaike and Geijzendorffer, Ilse and Adamescu, Mihai C. and J{\"a}hnig, Sonja C.},
  title     = {Safeguarding freshwater life beyond 2020},
  series = {Conservation letters},
  volume    = {14},
  journal   = {Conservation letters},
  number    = {1},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1755-263X},
  doi       = {10.1111/conl.12771},
  pages     = {17},
  year      = {2020},
  abstract  = {Plans are currently being drafted for the next decade of action on biodiversity-both the post-2020 Global Biodiversity Framework of the Convention on Biological Diversity (CBD) and Biodiversity Strategy of the European Union (EU). Freshwater biodiversity is disproportionately threatened and underprioritized relative to the marine and terrestrial biota, despite supporting a richness of species and ecosystems with their own intrinsic value and providing multiple essential ecosystem services. Future policies and strategies must have a greater focus on the unique ecology of freshwater life and its multiple threats, and now is a critical time to reflect on how this may be achieved. We identify priority topics including environmental flows, water quality, invasive species, integrated water resources management, strategic conservation planning, and emerging technologies for freshwater ecosystem monitoring. We synthesize these topics with decades of first-hand experience and recent literature into 14 special recommendations for global freshwater biodiversity conservation based on the successes and setbacks of European policy, management, and research. Applying and following these recommendations will inform and enhance the ability of global and European post-2020 biodiversity agreements to halt and reverse the rapid global decline of freshwater biodiversity.},
  language  = {en}
}
@article{KrokeSchmidtAminietal.2022,
  author    = {Kroke, Anja and Schmidt, Annemarie and Amini, Anna M. and Kalotai, Nicole and Lehmann, Andreas and Haardt, Julia and Bauer, J{\"u}rgen M. and Bischoff-Ferrari, Heike A. and Boeing, Heiner and Egert, Sarah and Ellinger, Sabine and K{\"u}hn, Tilman and Louis, Sandrine and Lorkowski, Stefan and Nimptsch, Katharina and Remer, Thomas and Schulze, Matthias B. and Siener, Roswitha and Stangl, Gabriele and Volkert, Dorothee and Zittermann, Armin and Buyken, Anette E. and Watzl, Bernhard and Schwingshackl, Lukas},
  title     = {Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society},
  series = {European journal of nutrition},
  volume    = {61},
  journal   = {European journal of nutrition},
  number    = {4},
  publisher = {Springer Nature},
  address   = {Heidelberg},
  organization    = {German Nutr Soc},
  issn      = {1436-6207},
  doi       = {10.1007/s00394-021-02789-5},
  pages     = {2091 -- 2101},
  year      = {2022},
  abstract  = {Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake.},
  language  = {en}
}
@article{CopeBaukmannKlingeretal.2021,
  author    = {Cope, Justin L. and Baukmann, Hannes A. and Klinger, J{\"o}rn E. and Ravarani, Charles N. J. and B{\"o}ttinger, Erwin and Konigorski, Stefan and Schmidt, Marco F.},
  title     = {Interaction-based feature selection algorithm outperforms polygenic risk score in predicting Parkinson's Disease status},
  series = {Frontiers in genetics},
  volume    = {12},
  journal   = {Frontiers in genetics},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-8021},
  doi       = {10.3389/fgene.2021.744557},
  pages     = {9},
  year      = {2021},
  abstract  = {Polygenic risk scores (PRS) aggregating results from genome-wide association studies are the state of the art in the prediction of susceptibility to complex traits or diseases, yet their predictive performance is limited for various reasons, not least of which is their failure to incorporate the effects of gene-gene interactions. Novel machine learning algorithms that use large amounts of data promise to find gene-gene interactions in order to build models with better predictive performance than PRS. Here, we present a data preprocessing step by using data-mining of contextual information to reduce the number of features, enabling machine learning algorithms to identify gene-gene interactions. We applied our approach to the Parkinson's Progression Markers Initiative (PPMI) dataset, an observational clinical study of 471 genotyped subjects (368 cases and 152 controls). With an AUC of 0.85 (95\% CI = [0.72; 0.96]), the interaction-based prediction model outperforms the PRS (AUC of 0.58 (95\% CI = [0.42; 0.81])). Furthermore, feature importance analysis of the model provided insights into the mechanism of Parkinson's disease. For instance, the model revealed an interaction of previously described drug target candidate genes TMEM175 and GAPDHP25. These results demonstrate that interaction-based machine learning models can improve genetic prediction models and might provide an answer to the missing heritability problem.},
  language  = {en}
}
@article{StroehleSchmidtSchultzetal.2015,
  author    = {Stroehle, Andreas and Schmidt, Dietlinde K. and Schultz, Florian and Fricke, Nina and Staden, Theresa and Hellweg, Rainer and Priller, Josef and Rapp, Michael A. and Rieckmann, Nina},
  title     = {Drug and Exercise Treatment of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Effects on Cognition in Randomized Controlled Trials},
  series = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  volume    = {23},
  journal   = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  number    = {12},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {1064-7481},
  doi       = {10.1016/j.jagp.2015.07.007},
  pages     = {1234 -- 1249},
  year      = {2015},
  abstract  = {Objective: Demographic changes are increasing the pressure to improve therapeutic strategies against cognitive decline in Alzheimer disease (AD) and mild cognitive impairment (MCI). Besides drug treatment, physical activity seems to be a promising intervention target as epidemiological and clinical studies suggest beneficial effects of exercise training on cognition. Using comparable inclusion and exclusion criteria, we analyzed the efficacy of drug therapy (cholinesterase inhibitors, memantine, and Ginkgo biloba) and exercise interventions for improving cognition in AD and MCI populations. Methods: We searched The Cochrane Library, EBSCO, OVID, Web of Science, and U.S Food and Drug Administration data from inception through October 30, 2013. Randomized controlled trials in which at least one treatment arm consisted of an exercise or a pharmacological intervention for AD or MCI patients, and which had either a non-exposed control condition or a control condition that received another intervention. Treatment discontinuation rates and Standardized Mean Change score using Raw score standardization (SMCR) of cognitive performance were calculated. Results: Discontinuation rates varied substantially and ranged between 0\% and 49\% with a median of 18\%. Significantly increased discontinuation rates were found for galantamine and rivastigmine as compared to placebo in AD studies. Drug treatments resulted in a small pooled effect on cognition (SMCR: 0.23, 95\% CI: 0.20 to 0.25) in AD studies (N = 45, 18,434 patients) and no effect in any of the MCI studies (N = 5, 3,693 patients; SMCR: 0.03, 95\% CI: 0.00 to 0.005). Exercise interventions had a moderate to strong pooled effect size (SMCR: 0.83, 95\% CI: 0.59 to 1.07) in AD studies (N = 4, 119 patients), and a small effect size (SMCR: 0.20, 95\% CI: 0.11 to 0.28) in MCI (N = 6, 443 patients). Conclusions: Drug treatments have a small but significant impact on cognitive functioning in AD and exercise has the potential to improve cognition in AD and MCI. Head-to-head trials with sufficient statistical power are necessary to directly compare efficacy, safety, and acceptability. Combining these two approaches might further increase the efficacy of each individual intervention. Identifier: PROSPERO (2013:CRD42013003910).},
  language  = {en}
}
@book{SchmidtWagnerSchwerdtfegeretal.2022,
  author    = {Schmidt, Thorsten Ingo and Wagner, Dieter and Schwerdtfeger, Roswitha and Sch{\"a}fer, Andrea and Musil, Andreas and Edeling, Thomas and Bauer, Hartmut and Kinyakin, Andrey and Loladze, Besik and Nehls, Danny and Maaß, Christian and Kuhlmann, Sabine and Kuckei, Daniel A. and Hein, Victoria and Wille, Robert and Franzke, Jochen and B{\"u}chner, Christiane},
  title     = {Festschrift f{\"u}r Dr. Christiane B{\"u}chner in W{\"u}rdigung ihres Wirkens am Kommunalwissenschaftlichen Institut (1994-2022)},
  series = {KWI Schriften},
  journal   = {KWI Schriften},
  number    = {13},
  editor    = {Franzke, Jochen},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-529-3},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-54498},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-544987},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {125},
  year      = {2022},
  abstract  = {Diese eher ungew{\"o}hnliche, aber sehr pers{\"o}nlich gehaltene Festschrift ist dem lang­j{\"a}hrigen Wirken von Dr. Christiane B{\"u}chner als „Gesch{\"a}ftsf{\"u}hrerin" am Kommunal­wissenschaftlichen Institut (KWI) der Universit{\"a}t Potsdam gewidmet. Die von Prof. Jochen Franzke zusammengestellte und herausgegebene Publikation enth{\"a}lt im ersten Teil neben dem Grußwort des Gesch{\"a}ftsf{\"u}hrenden Direktors des KWI Herrn Prof. Thorsten Ingo Schmidt eine Reihe pers{\"o}nlicher W{\"u}rdigungen von Kolleginnen und Kollegen, Gastwissenschaftlern und Mitarbeitenden, die seit 1994 in verschiedenen Phasen der Entwicklung des KWIs mit Dr. Christiane B{\"u}chner eng zusammengearbeitet haben. Der abschließende Dokumentationsteil der Publikation enth{\"a}lt neben Ausz{\"u}gen aus dem Schriftenverzeichnis von Dr. Christiane B{\"u}chner auch zwei Nachdrucke aus deren Feder zum Thema der Kreisgebietsreform in Brandenburg (von 2001) sowie {\"u}ber den Landkreis Barnim (von 2019).},
  language  = {de}
}