@misc{HeinzelRimpelStelzeletal.2017, author = {Heinzel, Stephan and Rimpel, J{\´e}r{\^o}me and Stelzel, Christine and Rapp, Michael A.}, title = {Transfer Effects to a Multimodal Dual-Task after Working Memory Training and Associated Neural Correlates in Older Adults}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-401921}, pages = {15}, year = {2017}, abstract = {Working memory (WM) performance declines with age. However, several studies have shown that WM training may lead to performance increases not only in the trained task, but also in untrained cognitive transfer tasks. It has been suggested that transfer effects occur if training task and transfer task share specific processing components that are supposedly processed in the same brain areas. In the current study, we investigated whether single-task WM training and training-related alterations in neural activity might support performance in a dual-task setting, thus assessing transfer effects to higher-order control processes in the context of dual-task coordination. A sample of older adults (age 60-72) was assigned to either a training or control group. The training group participated in 12 sessions of an adaptive n-back training. At pre and post-measurement, a multimodal dual-task was performed in all participants to assess transfer effects. This task consisted of two simultaneous delayed match to sample WM tasks using two different stimulus modalities (visual and auditory) that were performed either in isolation (single-task) or in conjunction (dual-task). A subgroup also participated in functional magnetic resonance imaging (fMRI) during the performance of the n-back task before and after training. While no transfer to single-task performance was found, dual-task costs in both the visual modality (p < 0.05) and the auditory modality (p < 0.05) decreased at post-measurement in the training but not in the control group. In the fMRI subgroup of the training participants, neural activity changes in left dorsolateral prefrontal cortex (DLPFC) during one-back predicted post-training auditory dual-task costs, while neural activity changes in right DLPFC during three-back predicted visual dual-task costs. Results might indicate an improvement in central executive processing that could facilitate both WM and dual-task coordination.}, language = {en} } @misc{BohlkenJacobSchaumetal.2017, author = {Bohlken, Jens and Jacob, Louis and Schaum, Peter and Rapp, Michael A. and Kostev, Karel}, title = {Hip fracture risk in patients with dementia in German primary care practices}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {395}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-404526}, pages = {12}, year = {2017}, abstract = {The aim was to analyze the risk of hip fracture in German primary care patients with dementia. This study included patients aged 65-90 from 1072 primary care practices who were first diagnosed with dementia between 2010 and 2013. Controls were matched (1:1) to cases for age, sex, and type of health insurance. The primary outcome was the diagnosis of hip fracture during the three-year follow-up period. A total of 53,156 dementia patients and 53,156 controls were included. A total of 5.3\% of patients and 0.7\% of controls displayed hip fracture after three years. Hip fracture occurred more frequently in dementia subjects living in nursing homes than in those living at home (9.2\% versus 4.3\%). Dementia, residence in nursing homes, and osteoporosis were risk factors for fracture development. Antidementia, antipsychotic, and antidepressant drugs generally had no significant impact on hip fracture risk when prescribed for less than six months. Dementia increased hip fracture risk in German primary care practices.}, language = {en} } @article{SyrykhNazarovaHerzschuhetal.2017, author = {Syrykh, Lydmila S. and Nazarova, Larisa B. and Herzschuh, Ulrike and Subetto, D. A. and Grekov, I. M.}, title = {Reconstruction of palaeoecological and palaeoclimatic conditions of the Holocene in the south of the Taimyr according to an analysis of lake sediments}, series = {Contemporary Problems of Ecology}, volume = {10}, journal = {Contemporary Problems of Ecology}, publisher = {Pleiades Publ.}, address = {New York}, issn = {1995-4255}, doi = {10.1134/S1995425517040114}, pages = {363 -- 369}, year = {2017}, abstract = {A sediment core from Khatanga-12 Lake (Taimyr Peninsula, Krasnoyarsk krai) has been studied. The 131.5-cm-long core covers ca. 7100 years of sedimentation. Chironomid analysis, a qualitative reconstruction of the paleoenvironment in the region, and a quantitative reconstruction of variations of the mean July air temperature and in the water depth of the lake have been performed using Northern Russia chironomid-inferred mean July temperature models (Nazarova et al., 2008, 2011, 2015). Khatanga-12 Lake was formed during the Middle Holocene warming as a result of thermokarst processes. The development of the lake ecosystem at different stages of its development was influenced by climatic and cryolithogenic factors. The Middle Holocene warming, which occurred around 7100-6250 cal. years BP, activated thermokarst processes and resulted in the formation of the lake basin. Later, between 6250 and 4500 cal. years BP, a period of cooling took place, as is proved by chironomid analysis. The bottom sediments of the lake during this period were formed by erosion processes on the lake shores. The reconstructed conditions were close to the modern after 2500 cal. years BP.}, language = {en} } @misc{ZibulskiWesenerWilkesetal.2017, author = {Zibulski, Romy and Wesener, Felix and Wilkes, Heinz and Plessen, Birgit and Pestryakova, Luidmila Agafyevna and Herzschuh, Ulrike}, title = {C / N ratio, stable isotope (δ 13 C, δ 15 N), and n-alkane patterns of brown mosses along hydrological gradients of low-centred polygons of the Siberian Arctic}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {672}, issn = {1866-8372}, doi = {10.25932/publishup-41710}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-417104}, pages = {14}, year = {2017}, abstract = {Mosses are a major component of the arctic vegetation, particularly in wetlands. We present C / N atomic ratio, delta C-13 and delta N-15 data of 400 brown-moss samples belonging to 10 species that were collected along hydrological gradients within polygonal mires located on the southern Taymyr Peninsula and the Lena River delta in northern Siberia. Additionally, n-alkane patterns of six of these species (16 samples) were investigated. The aim of the study is to see whether the inter-and intraspecific differences in C / N, isotopic compositions and n-alkanes are indicative of habitat, particularly with respect to water level. Overall, we find high variability in all investigated parameters for two different moisture-related groups of moss species. The C / N ratios range between 11 and 53 (median: 32) and show large variations at the intraspecific level. However, species preferring a dry habitat (xero-mesophilic mosses) show higher C / N ratios than those preferring a wet habitat (meso-hygrophilic mosses). The delta C-13 values range between 37.0 and 22.5\% (median D 27.8 \%). The delta N-15 values range between 6.6 and C 1.7\%(median D 2.2 \%). We find differences in delta C-13 and delta N-15 compositions between both habitat types. For some species of the meso-hygrophilic group, we suggest that a relationship between the individ-ual habitat water level and isotopic composition can be inferred as a function of microbial symbiosis. The n-alkane distribution also shows differences primarily between xeromesophilic and meso-hygrophilic mosses, i. e. having a dominance of n-alkanes with long (n-C29, n-C31 /and intermediate (n-C25 /chain lengths, respectively. Overall, our results reveal that C / N ratios, isotopic signals and n-alkanes of studied brown-moss taxa from polygonal wetlands are characteristic of their habitat.}, language = {en} } @article{BaayenVasishthKliegletal.2017, author = {Baayen, Harald R. and Vasishth, Shravan and Kliegl, Reinhold and Bates, Douglas}, title = {The cave of shadows: Addressing the human factor with generalized additive mixed models}, series = {Journal of memory and language}, volume = {94}, journal = {Journal of memory and language}, publisher = {Elsevier}, address = {San Diego}, issn = {0749-596X}, doi = {10.1016/j.jml.2016.11.006}, pages = {206 -- 234}, year = {2017}, language = {en} } @misc{KuhlmannTschornAroltetal.2017, author = {Kuhlmann, Stella L. and Tschorn, Mira and Arolt, Volker and Beer, Katja and Brandt, Julia and Grosse, Laura and Haverkamp, Wilhelm and Mueller-Nordhorn, Jacqueline and Rieckmann, Nina and Waltenberger, Johannes and Warnke, Katharina and Hellweg, Rainer and Stroehle, Andreas}, title = {Serum brain-derived neurotrophic factor and depressive symptoms in coronary heart disease patients: Role of cognitive functions Reply}, series = {Psychoneuroendocrinology}, volume = {79}, journal = {Psychoneuroendocrinology}, publisher = {Elsevier}, address = {Oxford}, issn = {0306-4530}, doi = {10.1016/j.psyneuen.2017.02.010}, pages = {175 -- 176}, year = {2017}, language = {en} } @article{WolffZuPaulkeetal.2017, author = {Wolff, Christian Michael and Zu, Fengshuo and Paulke, Andreas and Perdig{\´o}n-Toro, Lorena and Koch, Norbert and Neher, Dieter}, title = {Reduced Interface-Mediated Recombination for High Open-Circuit Voltages in CH3NH3PbI3 Solar Cells}, series = {Advanced materials}, volume = {29}, journal = {Advanced materials}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0935-9648}, doi = {10.1002/adma.201700159}, pages = {8}, year = {2017}, abstract = {Perovskite solar cells with all-organic transport layers exhibit efficiencies rivaling their counterparts that employ inorganic transport layers, while avoiding high-temperature processing. Herein, it is investigated how the choice of the fullerene derivative employed in the electron-transporting layer of inverted perovskite cells affects the open-circuit voltage (V-OC). It is shown that nonradiative recombination mediated by the electron-transporting layer is the limiting factor for the V-OC in the cells. By inserting an ultrathin layer of an insulating polymer between the active CH3NH3PbI3 perovskite and the fullerene, an external radiative efficiency of up to 0.3\%, a V-OC as high as 1.16 V, and a power conversion efficiency of 19.4\% are realized. The results show that the reduction of nonradiative recombination due to charge-blocking at the perovskite/organic interface is more important than proper level alignment in the search for ideal selective contacts toward high V-OC and efficiency.}, language = {en} } @article{MassonRabeKliegl2017, author = {Masson, Michael E. J. and Rabe, Maximilian M. and Kliegl, Reinhold}, title = {Modulation of additive and interactive effects by trial history revisited}, series = {Memory \& cognition}, volume = {45}, journal = {Memory \& cognition}, publisher = {Springer}, address = {New York}, issn = {0090-502X}, doi = {10.3758/s13421-016-0666-z}, pages = {480 -- 492}, year = {2017}, language = {en} } @article{MatuschekKliegl2017, author = {Matuschek, Hannes and Kliegl, Reinhold}, title = {On the ambiguity of interaction and nonlinear main effects in a regime of dependent covariates}, series = {Behavior research methods : a journal of the Psychonomic Society}, volume = {50}, journal = {Behavior research methods : a journal of the Psychonomic Society}, number = {5}, publisher = {Springer}, address = {New York}, issn = {1554-351X}, doi = {10.3758/s13428-017-0956-9}, pages = {1882 -- 1894}, year = {2017}, abstract = {The analysis of large experimental datasets frequently reveals significant interactions that are difficult to interpret within the theoretical framework guiding the research. Some of these interactions actually arise from the presence of unspecified nonlinear main effects and statistically dependent covariates in the statistical model. Importantly, such nonlinear main effects may be compatible (or, at least, not incompatible) with the current theoretical framework. In the present literature, this issue has only been studied in terms of correlated (linearly dependent) covariates. Here we generalize to nonlinear main effects (i.e., main effects of arbitrary shape) and dependent covariates. We propose a novel nonparametric method to test for ambiguous interactions where present parametric methods fail. We illustrate the method with a set of simulations and with reanalyses (a) of effects of parental education on their children's educational expectations and (b) of effects of word properties on fixation locations during reading of natural sentences, specifically of effects of length and morphological complexity of the word to be fixated next. The resolution of such ambiguities facilitates theoretical progress.}, language = {en} } @misc{JackischAngermannAllroggenetal.2017, author = {Jackisch, Conrad and Angermann, Lisa and Allroggen, Niklas and Sprenger, Matthias and Blume, Theresa and Tronicke, Jens and Zehe, Erwin}, title = {Form and function in hillslope hydrology}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {665}, issn = {1866-8372}, doi = {10.25932/publishup-41918}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-419188}, pages = {27}, year = {2017}, abstract = {The study deals with the identification and characterization of rapid subsurface flow structures through pedo- and geo-physical measurements and irrigation experiments at the point, plot and hillslope scale. Our investigation of flow-relevant structures and hydrological responses refers to the general interplay of form and function, respectively. To obtain a holistic picture of the subsurface, a large set of different laboratory, exploratory and experimental methods was used at the different scales. For exploration these methods included drilled soil core profiles, in situ measurements of infiltration capacity and saturated hydraulic conductivity, and laboratory analyses of soil water retention and saturated hydraulic conductivity. The irrigation experiments at the plot scale were monitored through a combination of dye tracer, salt tracer, soil moisture dynamics, and 3-D time-lapse ground penetrating radar (GPR) methods. At the hillslope scale the subsurface was explored by a 3-D GPR survey. A natural storm event and an irrigation experiment were monitored by a dense network of soil moisture observations and a cascade of 2-D time-lapse GPR "trenches". We show that the shift between activated and non-activated state of the flow paths is needed to distinguish structures from overall heterogeneity. Pedo-physical analyses of point-scale samples are the basis for sub-scale structure inference. At the plot and hillslope scale 3-D and 2-D time-lapse GPR applications are successfully employed as non-invasive means to image subsurface response patterns and to identify flow-relevant paths. Tracer recovery and soil water responses from irrigation experiments deliver a consistent estimate of response velocities. The combined observation of form and function under active conditions provides the means to localize and characterize the structures (this study) and the hydrological processes (companion study Angermann et al., 2017, this issue).}, language = {en} } @misc{AngermannJackischAllroggenetal.2017, author = {Angermann, Lisa and Jackisch, Conrad and Allroggen, Niklas and Sprenger, Matthias and Zehe, Erwin and Tronicke, Jens and Weiler, Markus and Blume, Theresa}, title = {Form and function in hillslope hydrology}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {658}, issn = {1866-8372}, doi = {10.25932/publishup-41916}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-419161}, pages = {22}, year = {2017}, abstract = {The phrase form and function was established in architecture and biology and refers to the idea that form and functionality are closely correlated, influence each other, and co-evolve. We suggest transferring this idea to hydrological systems to separate and analyze their two main characteristics: their form, which is equivalent to the spatial structure and static properties, and their function, equivalent to internal responses and hydrological behavior. While this approach is not particularly new to hydrological field research, we want to employ this concept to explicitly pursue the question of what information is most advantageous to understand a hydrological system. We applied this concept to subsurface flow within a hillslope, with a methodological focus on function: we conducted observations during a natural storm event and followed this with a hillslope-scale irrigation experiment. The results are used to infer hydrological processes of the monitored system. Based on these findings, the explanatory power and conclusiveness of the data are discussed. The measurements included basic hydrological monitoring methods, like piezometers, soil moisture, and discharge measurements. These were accompanied by isotope sampling and a novel application of 2-D time-lapse GPR (ground-penetrating radar). The main finding regarding the processes in the hillslope was that preferential flow paths were established quickly, despite unsaturated conditions. These flow paths also caused a detectable signal in the catchment response following a natural rainfall event, showing that these processes are relevant also at the catchment scale. Thus, we conclude that response observations (dynamics and patterns, i.e., indicators of function) were well suited to describing processes at the observational scale. Especially the use of 2-D time-lapse GPR measurements, providing detailed subsurface response patterns, as well as the combination of stream-centered and hillslope-centered approaches, allowed us to link processes and put them in a larger context. Transfer to other scales beyond observational scale and generalizations, however, rely on the knowledge of structures (form) and remain speculative. The complementary approach with a methodological focus on form (i.e., structure exploration) is presented and discussed in the companion paper by Jackisch et al. (2017).}, language = {en} } @article{ShahnejatBushehriAlluMehterovetal.2017, author = {Shahnejat-Bushehri, Sara and Allu, Annapurna Devi and Mehterov, Nikolay and Thirumalaikumar, Venkatesh P. and Alseekh, Saleh and Fernie, Alisdair R. and Mueller-Roeber, Bernd and Balazadeh, Salma}, title = {Arabidopsis NAC Transcription Factor JUNGBRUNNEN1 Exerts Conserved Control Over Gibberellin and Brassinosteroid Metabolism and Signaling Genes in Tomato}, series = {Frontiers in plant science}, volume = {8}, journal = {Frontiers in plant science}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-462X}, doi = {10.3389/fpls.2017.00214}, pages = {13}, year = {2017}, abstract = {The Arabidopsis thaliana NAC transcription factor JUNGBRUNNEN1 (AtJUB1) regulates growth by directly repressing GA3ox1 and DWF4, two key genes involved in gibberellin (GA) and brassinosteroid (BR) biosynthesis, respectively, leading to GA and BR deficiency phenotypes. AtJUB1 also reduces the expression of PIF4, a bHLH transcription factor that positively controls cell elongation, while it stimulates the expression of DELLA genes, which are important repressors of growth. Here, we extend our previous findings by demonstrating that AtJUB1 induces similar GA and BR deficiency phenotypes and changes in gene expression when overexpressed in tomato (Solanum lycopersicum). Importantly, and in accordance with the growth phenotypes observed, AtJUB1 inhibits the expression of growth-supporting genes, namely the tomato orthologs of GA3ox1, DWF4 and PIF4, but activates the expression of DELLA orthologs, by directly binding to their promoters. Overexpression of AtJUB1 in tomato delays fruit ripening, which is accompanied by reduced expression of several ripeningrelated genes, and leads to an increase in the levels of various amino acids (mostly proline, beta-alanine, and phenylalanine), gamma-aminobutyric acid (GABA), and major organic acids including glutamic acid and aspartic acid. The fact that AtJUB1 exerts an inhibitory effect on the GA/BR biosynthesis and PIF4 genes but acts as a direct activator of DELLA genes in both, Arabidopsis and tomato, strongly supports the model that the molecular constituents of the JUNGBRUNNEN1 growth control module are considerably conserved across species.}, language = {en} } @phdthesis{deSouza2017, author = {de Souza, Leonardo Perez}, title = {Functional characterization of biosynthesis and regulation of plant secondary metabolism}, school = {Universit{\"a}t Potsdam}, pages = {102}, year = {2017}, language = {en} } @article{MalinovaAlseekhFeiletal.2017, author = {Malinova, Irina and Alseekh, Saleh and Feil, Regina and Fernie, Alisdair R. and Baumann, Otto and Schoettler, Mark Aurel and Lunn, John Edward and Fettke, J{\"o}rg}, title = {Starch Synthase 4 and Plastidal Phosphorylase Differentially Affect Starch Granule Number and Morphology}, series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants}, volume = {174}, journal = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants}, publisher = {American Society of Plant Physiologists}, address = {Rockville}, issn = {0032-0889}, doi = {10.1104/pp.16.01859}, pages = {73 -- 85}, year = {2017}, abstract = {The process of starch granule formation in leaves of Arabidopsis ( Arabidopsis thaliana) is obscure. Besides STARCH SYNTHASE4 (SS4), the PLASTIDIAL PHOSPHORYLASE (PHS1) also seems to be involved, since dpe2-1/phs1a double mutants lacking both PHS1 and the cytosolic DISPROPORTIONATING ENZYME2 (DPE2) displayed only one starch granule per chloroplast under normal growth conditions. For further studies, a dpe2-1/phs1a/ss4 triple mutant and various combinations of double mutants were generated and metabolically analyzed with a focus on starch metabolism. The dpe2-1/phs1a/ ss4 mutant revealed a massive starch excess phenotype. Furthermore, these plants grown under 12 h of light/12 h of dark harbored a single large and spherical starch granule per plastid. The number of starch granules was constant when the light/dark regime was altered, but this was not observed in the parental lines. With regard to growth, photosynthetic parameters, and metabolic analyses, the triple mutant additionally displayed alterations in comparison with ss4 and dpe21/phs1a. The results clearly illustrate that PHS1 and SS4 are differently involved in starch granule formation and do not act in series. However, SS4 appears to exert a stronger influence. In connection with the characterized double mutants, we discuss the generation of starch granules and the observed formation of spherical starch granules.}, language = {en} } @article{RobainaEstevezDalosoZhangetal.2017, author = {Robaina-Estevez, Semidan and Daloso, Danilo M. and Zhang, Youjun and Fernie, Alisdair R. and Nikoloski, Zoran}, title = {Resolving the central metabolism of Arabidopsis guard cells}, series = {Scientific reports}, volume = {7}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-017-07132-9}, pages = {1913 -- 1932}, year = {2017}, abstract = {Photosynthesis and water use efficiency, key factors affecting plant growth, are directly controlled by microscopic and adjustable pores in the leaf-the stomata. The size of the pores is modulated by the guard cells, which rely on molecular mechanisms to sense and respond to environmental changes. It has been shown that the physiology of mesophyll and guard cells differs substantially. However, the implications of these differences to metabolism at a genome-scale level remain unclear. Here, we used constraint-based modeling to predict the differences in metabolic fluxes between the mesophyll and guard cells of Arabidopsis thaliana by exploring the space of fluxes that are most concordant to cell-type-specific transcript profiles. An independent C-13-labeling experiment using isolated mesophyll and guard cells was conducted and provided support for our predictions about the role of the Calvin-Benson cycle in sucrose synthesis in guard cells. The combination of in silico with in vivo analyses indicated that guard cells have higher anaplerotic CO2 fixation via phosphoenolpyruvate carboxylase, which was demonstrated to be an important source of malate. Beyond highlighting the metabolic differences between mesophyll and guard cells, our findings can be used in future integrated modeling of multicellular plant systems and their engineering towards improved growth.}, language = {en} } @article{GuentnerReichMikolajetal.2017, author = {G{\"u}ntner, Andreas and Reich, Marvin and Mikolaj, Michal and Creutzfeldt, Benjamin and Schroeder, Stephan and Wziontek, Hartmut}, title = {Landscape-scale water balance monitoring with an iGrav superconducting gravimeter in a field enclosure}, series = {Hydrology and earth system sciences : HESS}, volume = {21}, journal = {Hydrology and earth system sciences : HESS}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-21-3167-2017}, pages = {3167 -- 3182}, year = {2017}, language = {en} } @article{AdebayoHashimHassetal.2017, author = {Adebayo, Segun Emmanuel and Hashim, Norhashila and Hass, Roland and Reich, Oliver and Regen, Christian and M{\"u}nzberg, Marvin and Abdan, Khalina and Hanafi, Marsyita and Zude, Manuela}, title = {Using absorption and reduced scattering coefficients for non-destructive analyses of fruit flesh firmness and soluble solids content in pear}, series = {Postharvest Biology and Technology}, volume = {130}, journal = {Postharvest Biology and Technology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-5214}, doi = {10.1016/j.postharvbio.2017.04.004}, pages = {56 -- 63}, year = {2017}, abstract = {Quality attributes of fruit determine its acceptability by the retailer and consumer. The objective of this work was to investigate the potential of absorption (μa) and reduced scattering (μs') coefficients of European pear to analyze its fruit flesh firmness and soluble solids content (SSC). The absolute reference values, μa* (cm-1) and μs'* (cm-1), of pear were invasively measured, employing multi-spectral photon density wave (PDW) spectroscopy at preselected wavelengths of 515, 690, and 940 nm considering two batches of unripe and overripe fruit. On eight measuring dates during fruit development, μa and μs' were analyzed non-destructively by means of laser light backscattering imaging (LLBI) at similar wavelengths of 532, 660, and 830 nm by means of fitting according to Farrell's diffusion theory, using fix reference values of either μa* or μs'*. Both, the μa* and the μa as well as μs'* and μs' showed similar trends. Considering the non-destructively measured data during fruit development, μa at 660 nm decreased 91 till 141 days after full bloom (dafb) from 1.49 cm-1 to 0.74 cm-1 due to chlorophyll degradation. At 830 nm, μa only slightly decreased from 0.41 cm-1 to 0.35 cm-1. The μs' at all wavelengths revealed a decreasing trend as the fruit developed. The difference measured at 532 nm was most pronounced decreasing from 24 cm-1 to 10 cm-1, while at 660 nm and 830 nm values decreased from 15 cm-1 to 13 cm-1 and from 10 cm-1 to 8 cm-1, respectively. When building calibration models with partial least-squares regression analysis on the optical properties for non-destructive analysis of the fruit SSC, μa at 532 nm and 830 nm resulted in a correlation coefficient of R = 0.66, however, showing high measuring uncertainty. The combination of all three wavelengths gave an enhanced, encouraging R = 0.89 for firmness analysis using μs' in the freshly picked fruit.}, language = {en} } @article{MatuschekKlieglVasishthetal.2017, author = {Matuschek, Hannes and Kliegl, Reinhold and Vasishth, Shravan and Baayen, Harald R. and Bates, Douglas}, title = {Balancing Type I error and power in linear mixed models}, series = {Journal of memory and language}, volume = {94}, journal = {Journal of memory and language}, publisher = {Elsevier}, address = {San Diego}, issn = {0749-596X}, doi = {10.1016/j.jml.2017.01.001}, pages = {305 -- 315}, year = {2017}, abstract = {Linear mixed-effects models have increasingly replaced mixed-model analyses of variance for statistical inference in factorial psycholinguistic experiments. Although LMMs have many advantages over ANOVA, like ANOVAs, setting them up for data analysis also requires some care. One simple option, when numerically possible, is to fit the full variance covariance structure of random effects (the maximal model; Barr, Levy, Scheepers \& Tily, 2013), presumably to keep Type I error down to the nominal a in the presence of random effects. Although it is true that fitting a model with only random intercepts may lead to higher Type I error, fitting a maximal model also has a cost: it can lead to a significant loss of power. We demonstrate this with simulations and suggest that for typical psychological and psycholinguistic data, higher power is achieved without inflating Type I error rate if a model selection criterion is used to select a random effect structure that is supported by the data. (C) 2017 The Authors. Published by Elsevier Inc.}, language = {en} } @article{StolterfohtWolffAmiretal.2017, author = {Stolterfoht, Martin and Wolff, Christian Michael and Amir, Yohai and Paulke, Andreas and Perdig{\´o}n-Toro, Lorena and Caprioglio, Pietro and Neher, Dieter}, title = {Approaching the fill factor Shockley-Queisser limit in stable, dopant-free triple cation perovskite solar cells}, series = {Energy \& Environmental Science}, volume = {10}, journal = {Energy \& Environmental Science}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1754-5692}, doi = {10.1039/c7ee00899f}, pages = {1530 -- 1539}, year = {2017}, abstract = {Perovskite solar cells now compete with their inorganic counterparts in terms of power conversion efficiency, not least because of their small open-circuit voltage (V-OC) losses. A key to surpass traditional thin-film solar cells is the fill factor (FF). Therefore, more insights into the physical mechanisms that define the bias dependence of the photocurrent are urgently required. In this work, we studied charge extraction and recombination in efficient triple cation perovskite solar cells with undoped organic electron/hole transport layers (ETL/HTL). Using integral time of flight we identify the transit time through the HTL as the key figure of merit for maximizing the fill factor (FF) and efficiency. Complementarily, intensity dependent photocurrent and V-OC measurements elucidate the role of the HTL on the bias dependence of non-radiative and transport-related loss channels. We show that charge transport losses can be completely avoided under certain conditions, yielding devices with FFs of up to 84\%. Optimized cells exhibit power conversion efficiencies of above 20\% for 6 mm(2) sized pixels and 18.9\% for a device area of 1 cm(2). These are record efficiencies for hybrid perovskite devices with dopant-free transport layers, highlighting the potential of this device technology to avoid charge-transport limitations and to approach the Shockley-Queisser limit.}, language = {en} } @article{VogeliNajmanvanderBeeketal.2017, author = {Vogeli, Natalie and Najman, Yani and van der Beek, Pieter A. and Huyghe, Pascale and Wynn, Peter M. and Govin, Gwladys and van der Veen, Iris and Sachse, Dirk}, title = {Lateral variations in vegetation in the Himalaya since the Miocene and implications for climate evolution}, series = {Earth \& planetary science letters}, volume = {471}, journal = {Earth \& planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2017.04.037}, pages = {1 -- 9}, year = {2017}, abstract = {The Himalaya has a major influence on global and regional climate, in particular on the Asian monsoon system. The foreland basin of the Himalaya contains a record of tectonics and paleoclimate since the Miocene. Previous work on the evolution of vegetation and climate has focused on the central and western Himalaya, where a shift from C3 to C4 vegetation has been observed at similar to 7 Ma and linked to increased seasonality, but the climatic evolution of the eastern part of the orogen is less well understood. In order to track vegetation as a marker of monsoon intensity and seasonality, we analyzed delta C-13 and 8180 values of soil carbonate and associated delta C-13 values of bulk organic carbon from previously dated sedimentary sections exposing the syn-orogenic detrital Dharamsala and Siwalik Groups in the west, and, for the first time, the Siwalik Group in the east of the Himalayan foreland basin. Sedimentary records span from 20 to 1 Myr in the west (Joginder Nagar, Jawalamukhi, and Haripur Kolar sections) and from 13 to 1 Myr in the east (Kameng section), respectively. The presence of soil carbonate in the west and its absence in the east is a first indication of long-term lateral climatic variation, as soil carbonate requires seasonally arid conditions to develop. delta C-13 values in soil carbonate show a shift from around -10 parts per thousand to -2 parts per thousand at similar to 7 Ma in the west, which is confirmed by delta C-13 analyses on bulk organic carbon that show a shift from around -23 parts per thousand to -19 parts per thousand at the same time. Such a shift in isotopic values is likely to be associated with a change from C3 to C4 vegetation. In contrast, delta C-13 values of bulk organic carbon remain at 23 parts per thousand o in the east. Thus, our data show that the current east -west variation in climate was established at similar to 7 Ma. We propose that the regional change towards a more seasonal climate in the west is linked to a decrease of the influence of the Westerlies, delivering less winter precipitation to the western Himalaya, while the east remained annually humid due to its proximity to the monsoonal moisture source. (C) 2017 Elsevier B.V. All rights reserved.}, language = {en} } @article{EichlerRabeSalzwedeletal.2017, author = {Eichler, Sarah and Rabe, Sophie and Salzwedel, Annett and Mueller, Steffen and Stoll, Josefine and Tilgner, Nina and John, Michael and Wegscheider, Karl and Mayer, Frank and V{\"o}ller, Heinz}, title = {Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement: study protocol for a multicenter, superiority, no-blinded randomized controlled trial}, series = {Trials}, volume = {18}, journal = {Trials}, publisher = {BioMed Central}, address = {London}, issn = {1745-6215}, doi = {10.1186/s13063-017-2173-3}, pages = {7}, year = {2017}, abstract = {Background: Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain. Methods/design: This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints. Discussion: We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas.}, language = {en} } @article{EichlerRabeSalzwedeletal.2017, author = {Eichler, Sarah and Rabe, Sophie and Salzwedel, Annett and M{\"u}ller, Steffen and Stoll, Josefine and Tilgner, Nina and John, Michael and Wegschneider, Karl and Mayer, Frank and V{\"o}ller, Heinz}, title = {Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement}, series = {Trials}, volume = {18}, journal = {Trials}, publisher = {BioMed Central}, address = {London}, issn = {1745-6215}, doi = {10.1186/s13063-017-2173-3}, pages = {1 -- 7}, year = {2017}, abstract = {Background Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain. Methods/design This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints. Discussion We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas.}, language = {en} } @misc{HirschmuellerBaurBraunetal.2017, author = {Hirschmueller, Anja and Baur, Heiner and Braun, Sepp and Kreuz, Peter C. and Suedkamp, Norbert P and Niemeyer, Philipp}, title = {Rehabilitation after autologous chondrocyte implantation for isolated cartilage defects of the knee}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-403170}, pages = {11}, year = {2017}, abstract = {Autologous chondrocyte implantation for treatment of isolated cartilage defects of the knee has become well established. Although various publications report technical modifications, clinical results, and cell-related issues, little is known about appropriate and optimal rehabilitation after autologous chondrocyte implantation. This article reviews the literature on rehabilitation after autologous chondrocyte implantation and presents a rehabilitation protocol that has been developed considering the best available evidence and has been successfully used for several years in a large number of patients who underwent autologous chondrocyte implantation for cartilage defects of the knee.}, language = {en} } @article{EngelMuellerKopinskietal.2017, author = {Engel, Tilman and Mueller, Juliane and Kopinski, Stephan and Reschke, Antje and Mueller, Steffen and Mayer, Frank}, title = {Unexpected walking perturbations: Reliability and validity of a new treadmill protocol to provoke muscular reflex activities at lower extremities and the trunk}, series = {Journal of biomechanics}, volume = {55}, journal = {Journal of biomechanics}, publisher = {Elsevier}, address = {Oxford}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2017.02.026}, pages = {152 -- 155}, year = {2017}, abstract = {Instrumented treadmills offer the potential to generate standardized walking perturbations, which are particularly rapid and powerful. However, technical requirements to release adequate perturbations regarding timing, duration and amplitude are demanding. This study investigated the test-retest reliability and validity of a new treadmill perturbation protocol releasing rapid and unexpected belt perturbations to provoke muscular reflex responses at lower extremities and the trunk. Fourteen healthy participants underwent two identical treadmill walking protocols, consisting of 10 superimposed one-sided belt perturbations (100 ms duration; 2 m/s amplitude), triggered by a plantar pressure insole 200 ms after heel contact. Delay, duration and amplitude of applied perturbations were recorded by 3D-motion capture. Muscular reflex responses (within 200 ms) were measured at lower extremities and the trunk (10-lead EMG). Data was analyzed descriptively (mean +/- SD). Reliability was analyzed using test-retest variability (TRV\%) and limits of agreement (LoA, bias +/- 1.96*SD). Perturbation delay was 202 14 ms, duration was 102 +/- 4 ms and amplitude was 2.1 +/- 0.01 m/s. TRV for perturbation delay, duration and amplitude ranged from 5.0\% to 5.7\%. LoA reached 3 +/- 36 ms for delay, 2 +/- 13 ms for duration and 0.0 +/- 0.3 m/s for amplitude. EMG amplitudes following perturbations ranged between 106 +/- 97\% and 909 +/- 979\% of unperturbed gait and EMG latencies between 82 +/- 14 ms and 106 +/- 16 ms. Minor differences between preset and observed perturbation characteristics and results of test-retest analysis prove a high validity with excellent reliability of the setup. Therefore, the protocol tested can be recommended to provoke muscular reflex responses at lower extremities and the trunk in perturbed walking. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} } @article{MuellerStollCasseletal.2017, author = {M{\"u}ller, Steffen and Stoll, Josefine and Cassel, Michael and Mayer, Frank}, title = {Trunk Muscle Activity during Drop Jump Performance in Adolescent Athletes with Back Pain}, series = {Frontiers in physiology}, volume = {8}, journal = {Frontiers in physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2017.00274}, year = {2017}, abstract = {In the context of back pain, great emphasis has been placed on the importance of trunk stability, especially in situations requiring compensation of repetitive, intense loading induced during high-performance activities, e.g., jumping or landing. This study aims to evaluate trunk muscle activity during drop jump in adolescent athletes with back pain (BP) compared to athletes without back pain (NBP). Eleven adolescent athletes suffering back pain (BP: m/f: n = 4/7; 15.9 ± 1.3 y; 176 ± 11 cm; 68 ± 11 kg; 12.4 ± 10.5 h/we training) and 11 matched athletes without back pain (NBP: m/f: n = 4/7; 15.5 ± 1.3 y; 174 ± 7 cm; 67 ± 8 kg; 14.9 ± 9.5 h/we training) were evaluated. Subjects conducted 3 drop jumps onto a force plate (ground reaction force). Bilateral 12-lead SEMG (surface Electromyography) was applied to assess trunk muscle activity. Ground contact time [ms], maximum vertical jump force [N], jump time [ms] and the jump performance index [m/s] were calculated for drop jumps. SEMG amplitudes (RMS: root mean square [\%]) for all 12 single muscles were normalized to MIVC (maximum isometric voluntary contraction) and analyzed in 4 time windows (100 ms pre- and 200 ms post-initial ground contact, 100 ms pre- and 200 ms post-landing) as outcome variables. In addition, muscles were grouped and analyzed in ventral and dorsal muscles, as well as straight and transverse trunk muscles. Drop jump ground reaction force variables did not differ between NBP and BP (p > 0.05). Mm obliquus externus and internus abdominis presented higher SEMG amplitudes (1.3-1.9-fold) for BP (p < 0.05). Mm rectus abdominis, erector spinae thoracic/lumbar and latissimus dorsi did not differ (p > 0.05). The muscle group analysis over the whole jumping cycle showed statistically significantly higher SEMG amplitudes for BP in the ventral (p = 0.031) and transverse muscles (p = 0.020) compared to NBP. Higher activity of transverse, but not straight, trunk muscles might indicate a specific compensation strategy to support trunk stability in athletes with back pain during drop jumps. Therefore, exercises favoring the transverse trunk muscles could be recommended for back pain treatment.}, language = {en} } @article{CasselIntziegianniRischetal.2017, author = {Cassel, Michael and Intziegianni, Konstantina and Risch, Lucie and M{\"u}ller, Steffen and Engel, Tilman and Mayer, Frank}, title = {Physiological Tendon Thickness Adaptation in Adolescent Elite Athletes}, series = {Frontiers in physiology}, volume = {8}, journal = {Frontiers in physiology}, publisher = {Frontiers}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2017.00795}, pages = {1 -- 8}, year = {2017}, abstract = {Increased Achilles (AT) and Patellar tendon (PT) thickness in adolescent athletes compared to non-athletes could be shown. However, it is unclear, if changes are of pathological or physiological origin due to training. The aim of this study was to determine physiological AT and PT thickness adaptation in adolescent elite athletes compared to non-athletes, considering sex and sport. In a longitudinal study design with two measurement days (M1/M2) within an interval of 3.2 ± 0.8 years, 131 healthy adolescent elite athletes (m/f: 90/41) out of 13 different sports and 24 recreationally active controls (m/f: 6/18) were included. Both ATs and PTs were measured at standardized reference points. Athletes were divided into 4 sport categories [ball (B), combat (C), endurance (E) and explosive strength sports (S)]. Descriptive analysis (mean ± SD) and statistical testing for group differences was performed (α = 0.05). AT thickness did not differ significantly between measurement days, neither in athletes (5.6 ± 0.7 mm/5.6 ± 0.7 mm) nor in controls (4.8 ± 0.4 mm/4.9 ± 0.5 mm, p > 0.05). For PTs, athletes presented increased thickness at M2 (M1: 3.5 ± 0.5 mm, M2: 3.8 ± 0.5 mm, p < 0.001). In general, males had thicker ATs and PTs than females (p < 0.05). Considering sex and sports, only male athletes from B, C, and S showed significant higher PT-thickness at M2 compared to controls (p ≤ 0.01). Sport-specific adaptation regarding tendon thickness in adolescent elite athletes can be detected in PTs among male athletes participating in certain sports with high repetitive jumping and strength components. Sonographic microstructural analysis might provide an enhanced insight into tendon material properties enabling the differentiation of sex and influence of different sports.}, language = {en} } @article{KleinpeterKoch2017, author = {Kleinpeter, Erich and Koch, Andreas}, title = {Identification of mesomeric substructures by through-space NMR shieldings (TSNMRS). Trimethine cyanine/merocyanine-like or aromatic pi-electron delocalization?}, series = {Tetrahedron}, volume = {73}, journal = {Tetrahedron}, publisher = {Elsevier}, address = {Oxford}, issn = {0040-4020}, doi = {10.1016/j.tet.2017.05.062}, pages = {4265 -- 4274}, year = {2017}, abstract = {The spatial magnetic properties, through-space NMR shieldings (TSNMRS), of amino-substituted heteraromatic six-membered ring systems such as pyrylium/thiopyrylium analogues have been calculated using the GIAO perturbation method employing the nucleus independent chemical shift (NICS) concept and visualized as iso-chemical-shielding surfaces (ICSS) of various size and direction. The TSNMRS values were employed to quantify and visualize the existing aromaticity of the studied compounds. Due to strong conjugation of six-membered ring pi-electrons and lone pairs of the exo-cyclic amino substituents (restricted rotation about partial C,N double bonds) the interplay of still aromatic and already dominating trimethine cyanine/merocyanine-like substructures can be estimated. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} } @article{MartinezValdesFallaNegroetal.2017, author = {Martinez-Valdes, Eduardo Andr{\´e}s and Falla, Deborah and Negro, Francesco and Mayer, Frank and Farina, Dario}, title = {Differential Motor Unit Changes after Endurance or High-Intensity Interval Training}, series = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, volume = {49}, journal = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0195-9131}, doi = {10.1249/MSS.0000000000001209}, pages = {1126 -- 1136}, year = {2017}, abstract = {Purpose Using a novel technique of high-density surface EMG decomposition and motor unit (MU) tracking, we compared changes in the properties of vastus medialis and vastus lateralis MU after endurance (END) and high-intensity interval training (HIIT). Methods Sixteen men were assigned to the END or the HIIT group (n = 8 each) and performed six training sessions for 14 d. Each session consisted of 8-12 x 60-s intervals at 100\% peak power output separated by 75 s of recovery (HIIT) or 90-120 min continuous cycling at similar to 65\% VO2peak (END). Pre- and postintervention, participants performed 1) incremental cycling to determine VO2peak and peak power output and 2) maximal, submaximal (10\%, 30\%, 50\%, and 70\% maximum voluntary contraction [MVC]), and sustained (until task failure at 30\% MVC) isometric knee extensions while high-density surface EMG signals were recorded from the vastus medialis and vastus lateralis. EMG signals were decomposed (submaximal contractions) into individual MU by convolutive blind source separation. Finally, MU were tracked across sessions by semiblind source separation. Results After training, END and HIIT improved VO2peak similarly (by 5.0\% and 6.7\%, respectively). The HIIT group showed enhanced maximal knee extension torque by similar to 7\% (P = 0.02) and was accompanied by an increase in discharge rate for high-threshold MU (50\% knee extension MVC) (P < 0.05). By contrast, the END group increased their time to task failure by similar to 17\% but showed no change in MU discharge rates (P > 0.05). Conclusions HIIT and END induce different adjustments in MU discharge rate despite similar improvements in cardiopulmonary fitness. Moreover, the changes induced by HIIT are specific for high-threshold MU. For the first time, we show that HIIT and END induce specific neuromuscular adaptations, possibly related to differences in exercise load intensity and training volume.}, language = {en} } @article{WochatzRabeWolteretal.2017, author = {Wochatz, Monique and Rabe, Sophie and Wolter, Martin and Engel, Tilman and Mueller, Steffen and Mayer, Frank}, title = {Reproducibility of scapular muscle activity in isokinetic shoulder flexion and extension}, series = {Journal of electromyography and kinesiology}, volume = {34}, journal = {Journal of electromyography and kinesiology}, publisher = {Elsevier}, address = {Oxford}, issn = {1050-6411}, doi = {10.1016/j.jelekin.2017.04.006}, pages = {86 -- 92}, year = {2017}, abstract = {Repetitive overhead movements have been identified as a main risk factor to develop shoulder complaints with scapular muscle activity being altered. Reliable assessment of muscle activity is essential to differentiate between symptomatic and asymptomatic individuals. Therefore, the present study aimed to investigate the intra-and inter-session reliability of scapular muscle activity during maximal isokinetic shoulder flexion and extension. Eleven asymptomatic adults performed maximum effort isokinetic shoulder flexion and extension (concentric and eccentric at 60 degrees/s) in a test-retest design. Muscle activity of the upper and lower trapezius and serratus anterior was assessed by sEMG. Root Mean Square was calculated for whole ROM and single movement phases of absolute and normalized muscle activity. Absolute (Bland-Altman analysis (Bias, LoA), Minimal detectable change (MDC)) and relative reliability parameters (Intraclass correlation coefficient (ICC), coefficient of variation (CV)/test-retest variability (TRV)) were utilized for the evaluation of reproducibility. Intra-session reliability revealed ICCs between 0.56 and 0.98, averaged CVs of 18\% and average MDCs of 81 mV. Inter-session reliability resulted in ICCs between 0.13 and 0.93, averaged TRVs of 21\%, average MDCs of 15\% and systematic and random error between -8 +/- 60\% and 12 +/- 36\%. Scapular muscle activity assessed in overhead movements can be measured reliably under maximum load conditions, though variability is dependent on the movement phase. Measurement variability does not exceed magnitudes of altered scapular muscle activities as reported in previous studies. Therefore, maximum load application is a promising approach for the evaluation of changes in scapular control related to pathologies. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} } @article{ShainyanKirpichenkoKleinpeter2017, author = {Shainyan, Bagrat A. and Kirpichenko, Svetlana V. and Kleinpeter, Erich}, title = {Conformational Preferences of the Phenyl Group in 1-Phenyl-1-X-1-silacyclo-hexanes (X = MeO, HO) and 3-Phenyl-3-X-3-silatetrahydropyrans (X = HO, H) by Low Temperature C-13 NMR Spectroscopy and Theoretical Calculations}, series = {The journal of organic chemistry}, volume = {82}, journal = {The journal of organic chemistry}, publisher = {American Chemical Society}, address = {Washington}, issn = {0022-3263}, doi = {10.1021/acs.joc.7b02505}, pages = {13414 -- 13422}, year = {2017}, abstract = {New Si-phenyl-substituted silacyclohexanes and 3-silatetrahydropyrans have been synthesized and studied with respect to the conformational equilibria of the heterosix-membered ring by low temperature C-13 NMR spectroscopy and quantum chemical calculations. For 1-methoxy-1-phenylsilacyclohexane 1 and 3-phenyl-3-silatetrahydropyran 4 the conformational equilibria could be frozen and assigned. The Ph-ax reversible arrow Ph-eq equilibrium constants at 103 K are 2.21 for 1 and 4.59 for 4. In complete agreement with former studies of similar silicon compounds, molecules 1 and 4 prefer to adopt the Pheq conformation. The conformational equilibria of 1-hydroxy-1-phenylsilacydohexane 2 and 3-hydroxy-3-phenyl-3-silatetrahydropyran 3 could not be frozen at 100 K and proved to be heavily one-sided (if not anancomeric). Obviously, there is a general trend of predominance of Phax conformer in the gas phase and of Pheq in solution. For the isolated molecules of silanols 2 and 3, calculations allowed to explain the axial predominance of the phenyl group by a larger polarization of the Si-Ph than of the Si-O bond in the Phax conformer and additional destabilization of 3-Ph-eq conformer by repulsion of unidirectional dipoles of the endocyclic oxygen lone pair and of the highly polar axial Si-O bond.}, language = {en} } @article{KleinpeterWernerLinker2017, author = {Kleinpeter, Erich and Werner, Peter and Linker, Torsten}, title = {Synthesis and NMR spectroscopic conformational analysis of benzoic acid esters of mono- and 1,4-dihydroxycyclohexane, 4-hydroxycyclohexanone and the -ene analogue - The more polar the molecule the more stable the axial conformer}, series = {Tetrahedron}, volume = {73}, journal = {Tetrahedron}, publisher = {Elsevier}, address = {Oxford}, issn = {0040-4020}, doi = {10.1016/j.tet.2017.04.029}, pages = {3801 -- 3809}, year = {2017}, abstract = {para-Substituted benzoic acid esters of cyclohexanol, 1,4-dihydroxycyclohexane, 4-hydroxy-cyclohexanone and of the corresponding exo-methylene derivative were synthesized and the conformational equilibria of the cyclohexane skeleton studied by low temperature H-1 and C-13 NMR spectroscopy. The geometry optimized structures of the axial/equatorial chair conformers were computed at the DFT level of theory. Only one preferred conformation of the ester group was obtained for both the axial and the equatorial conformer, respectively. The content of the axial conformer increases with growing polarity of the 6-membered ring moiety; hereby, in addition, the effect of sp(2) hybridization/polarity of C(4)= O/C(4)= CH2 on the present conformational equilibria is critically evaluated. Another dynamic process could be studied, for the first time in this kind of compounds. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} } @article{KleinpeterHeydenreichKochetal.2017, author = {Kleinpeter, Erich and Heydenreich, Matthias and Koch, Andreas and Krtitschka, Angela and Kr{\"u}ger, Tobias and Linker, Torsten}, title = {NMR spectroscopic conformational analysis of 4-methylene-cyclohexyl pivalateThe effect of sp(2) hybridization}, series = {Magnetic resonance in chemistry}, volume = {55}, journal = {Magnetic resonance in chemistry}, publisher = {Wiley}, address = {Hoboken}, issn = {0749-1581}, doi = {10.1002/mrc.4630}, pages = {1073 -- 1078}, year = {2017}, abstract = {The conformational equilibrium of the axial/equatorial conformers of 4-methylene-cyclohexyl pivalate is studied by dynamic NMR spectroscopy in a methylene chloride/freon mixture. At 153K, the ring interconversion gets slow on the nuclear magnetic resonance timescale, the conformational equilibrium (-G degrees) can be examined, and the barrier to ring interconversion (G(\#)) can be determined. The structural influence of sp(2) hybridization on both G degrees and G(\#) of the cyclohexyl moiety can be quantified.}, language = {en} } @misc{MuellerEngelMuelleretal.2017, author = {M{\"u}ller, Juliane and Engel, Tilman and M{\"u}ller, Steffen and Stoll, Josefine and Baur, Heiner and Mayer, Frank}, title = {Effects of sudden walking perturbations on neuromuscular reflex activity and three-dimensional motion of the trunk in healthy controls and back pain symptomatic subjects}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-394931}, pages = {11}, year = {2017}, abstract = {Background Back pain patients (BPP) show delayed muscle onset, increased co-contractions, and variability as response to quasi-static sudden trunk loading in comparison to healthy controls (H). However, it is unclear whether these results can validly be transferred to suddenly applied walking perturbations, an automated but more functional and complex movement pattern. There is an evident need to develop research-based strategies for the rehabilitation of back pain. Therefore, the investigation of differences in trunk stability between H and BPP in functional movements is of primary interest in order to define suitable intervention regimes. The purpose of this study was to analyse neuromuscular reflex activity as well as three-dimensional trunk kinematics between H and BPP during walking perturbations. Methods Eighty H (31m/49f;29±9yrs;174±10cm;71±13kg) and 14 BPP (6m/8f;30±8yrs;171±10cm;67±14kg) walked (1m/s) on a split-belt treadmill while 15 right-sided perturbations (belt decelerating, 40m/s2, 50ms duration; 200ms after heel contact) were randomly applied. Trunk muscle activity was assessed using a 12-lead EMG set-up. Trunk kinematics were measured using a 3-segment-model consisting of 12 markers (upper thoracic (UTA), lower thoracic (LTA), lumbar area (LA)). EMG-RMS ([\%],0-200ms after perturbation) was calculated and normalized to the RMS of unperturbed gait. Latency (TON;ms) and time to maximum activity (TMAX;ms) were analysed. Total motion amplitude (ROM;[°]) and mean angle (Amean;[°]) for extension-flexion, lateral flexion and rotation were calculated (whole stride cycle; 0-200ms after perturbation) for each of the three segments during unperturbed and perturbed gait. For ROM only, perturbed was normalized to unperturbed step [\%] for the whole stride as well as the 200ms after perturbation. Data were analysed descriptively followed by a student´s t-test to account for group differences. Co-contraction was analyzed between ventral and dorsal muscles (V:R) as well as side right:side left ratio (Sright:Sleft). The coefficient of variation (CV;\%) was calculated (EMG-RMS;ROM) to evaluate variability between the 15 perturbations for all groups. With respect to unequal distribution of participants to groups, an additional matched-group analysis was conducted. Fourteen healthy controls out of group H were sex-, age- and anthropometrically matched (group Hmatched) to the BPP. Results No group differences were observed for EMG-RMS or CV analysis (EMG/ROM) (p>0.025). Co-contraction analysis revealed no differences for V:R and Srigth:Sleft between the groups (p>0.025). BPP showed an increased TON and TMAX, being significant for Mm. rectus abdominus (p = 0.019) and erector spinae T9/L3 (p = 0.005/p = 0.015). ROM analysis over the unperturbed stride cycle revealed no differences between groups (p>0.025). Normalization of perturbed to unperturbed step lead to significant differences for the lumbar segment (LA) in lateral flexion with BPP showing higher normalized ROM compared to Hmatched (p = 0.02). BPP showed a significant higher flexed posture (UTA (p = 0.02); LTA (p = 0.004)) during normal walking (Amean). Trunk posture (Amean) during perturbation showed higher trunk extension values in LTA segments for H/Hmatched compared to BPP (p = 0.003). Matched group (BPP vs. Hmatched) analysis did not show any systematic changes of all results between groups. Conclusion BPP present impaired muscle response times and trunk posture, especially in the sagittal and transversal planes, compared to H. This could indicate reduced trunk stability and higher loading during gait perturbations.}, language = {en} } @article{MuellerEngelMuelleretal.2017, author = {M{\"u}ller, Juliane and Engel, Tilman and M{\"u}ller, Steffen and Stoll, Josefine and Baur, Heiner and Mayer, Frank}, title = {Effects of sudden walking perturbations on neuromuscular reflex activity and three-dimensional motion of the trunk in healthy controls and back pain symptomatic subjects}, series = {PLoS one}, volume = {12}, journal = {PLoS one}, number = {3}, publisher = {PLoS}, address = {Lawrence, Kan.}, issn = {1932-6203}, doi = {10.1371/journal.pone.0174034}, pages = {11}, year = {2017}, abstract = {Background Back pain patients (BPP) show delayed muscle onset, increased co-contractions, and variability as response to quasi-static sudden trunk loading in comparison to healthy controls (H). However, it is unclear whether these results can validly be transferred to suddenly applied walking perturbations, an automated but more functional and complex movement pattern. There is an evident need to develop research-based strategies for the rehabilitation of back pain. Therefore, the investigation of differences in trunk stability between H and BPP in functional movements is of primary interest in order to define suitable intervention regimes. The purpose of this study was to analyse neuromuscular reflex activity as well as three-dimensional trunk kinematics between H and BPP during walking perturbations. Methods Eighty H (31m/49f;29±9yrs;174±10cm;71±13kg) and 14 BPP (6m/8f;30±8yrs;171±10cm;67±14kg) walked (1m/s) on a split-belt treadmill while 15 right-sided perturbations (belt decelerating, 40m/s2, 50ms duration; 200ms after heel contact) were randomly applied. Trunk muscle activity was assessed using a 12-lead EMG set-up. Trunk kinematics were measured using a 3-segment-model consisting of 12 markers (upper thoracic (UTA), lower thoracic (LTA), lumbar area (LA)). EMG-RMS ([\%],0-200ms after perturbation) was calculated and normalized to the RMS of unperturbed gait. Latency (TON;ms) and time to maximum activity (TMAX;ms) were analysed. Total motion amplitude (ROM;[°]) and mean angle (Amean;[°]) for extension-flexion, lateral flexion and rotation were calculated (whole stride cycle; 0-200ms after perturbation) for each of the three segments during unperturbed and perturbed gait. For ROM only, perturbed was normalized to unperturbed step [\%] for the whole stride as well as the 200ms after perturbation. Data were analysed descriptively followed by a student´s t-test to account for group differences. Co-contraction was analyzed between ventral and dorsal muscles (V:R) as well as side right:side left ratio (Sright:Sleft). The coefficient of variation (CV;\%) was calculated (EMG-RMS;ROM) to evaluate variability between the 15 perturbations for all groups. With respect to unequal distribution of participants to groups, an additional matched-group analysis was conducted. Fourteen healthy controls out of group H were sex-, age- and anthropometrically matched (group Hmatched) to the BPP. Results No group differences were observed for EMG-RMS or CV analysis (EMG/ROM) (p>0.025). Co-contraction analysis revealed no differences for V:R and Srigth:Sleft between the groups (p>0.025). BPP showed an increased TON and TMAX, being significant for Mm. rectus abdominus (p = 0.019) and erector spinae T9/L3 (p = 0.005/p = 0.015). ROM analysis over the unperturbed stride cycle revealed no differences between groups (p>0.025). Normalization of perturbed to unperturbed step lead to significant differences for the lumbar segment (LA) in lateral flexion with BPP showing higher normalized ROM compared to Hmatched (p = 0.02). BPP showed a significant higher flexed posture (UTA (p = 0.02); LTA (p = 0.004)) during normal walking (Amean). Trunk posture (Amean) during perturbation showed higher trunk extension values in LTA segments for H/Hmatched compared to BPP (p = 0.003). Matched group (BPP vs. Hmatched) analysis did not show any systematic changes of all results between groups. Conclusion BPP present impaired muscle response times and trunk posture, especially in the sagittal and transversal planes, compared to H. This could indicate reduced trunk stability and higher loading during gait perturbations.}, language = {en} } @misc{WahmkowCasselMayeretal.2017, author = {Wahmkow, Gunnar and Cassel, Michael and Mayer, Frank and Baur, Heiner}, title = {Effects of different medial arch support heights on rearfoot kinematics}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-402934}, pages = {11}, year = {2017}, abstract = {Background Foot orthoses are usually assumed to be effective by optimizing mechanically dynamic rearfoot configuration. However, the effect from a foot orthosis on kinematics that has been demonstrated scientifically has only been marginal. The aim of this study was to examine the effect of different heights in medial arch-supported foot orthoses on rear foot motion during gait. Methods Nineteen asymptomatic runners (36±11years, 180±5cm, 79±10kg; 41±22km/week) participated in the study. Trials were recorded at 3.1 mph (5 km/h) on a treadmill. Athletes walked barefoot and with 4 different not customized medial arch-supported foot orthoses of various arch heights (N:0 mm, M:30 mm, H:35 mm, E:40mm). Six infrared cameras and the `Oxford Foot Model´ were used to capture motion. The average stride in each condition was calculated from 50 gait cycles per condition. Eversion excursion and internal tibia rotation were analyzed. Descriptive statistics included calculating the mean ± SD and 95\% CIs. Group differences by condition were analyzed by one factor (foot orthoses) repeated measures ANOVA (α = 0.05). Results Eversion excursion revealed the lowest values for N and highest for H (B:4.6°±2.2°; 95\% CI [3.1;6.2]/N:4.0°±1.7°; [2.9;5.2]/M:5.2°±2.6°; [3.6;6.8]/H:6.2°±3.3°; [4.0;8.5]/E:5.1°±3.5°; [2.8;7.5]) (p>0.05). Range of internal tibia rotation was lowest with orthosis H and highest with E (B:13.3°±3.2°; 95\% CI [11.0;15.6]/N:14.5°±7.2°; [9.2;19.6]/M:13.8°±5.0°; [10.8;16.8]/H:12.3°±4.3°; [9.0;15.6]/E:14.9°±5.0°; [11.5;18.3]) (p>0.05). Differences between conditions were small and the intrasubject variation high. Conclusion Our results indicate that different arch support heights have no systematic effect on eversion excursion or the range of internal tibia rotation and therefore might not exert a crucial influence on rear foot alignment during gait.}, language = {en} } @misc{KappelCuongNguyenHuuLenhard2017, author = {Kappel, Christian and Cuong Nguyen Huu, and Lenhard, Michael}, title = {A short story gets longer: recent insights into the molecular basis of heterostyly}, series = {Journal of experimental botany}, volume = {68}, journal = {Journal of experimental botany}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0022-0957}, doi = {10.1093/jxb/erx387}, pages = {5719 -- 5730}, year = {2017}, abstract = {Heterostyly is a fascinating adaptation to promote outbreeding and a classical paradigm of botany. In the most common type of heterostyly, plants either form flowers with long styles and short stamens, or short styles and long stamens. This reciprocal organ positioning reduces pollen wastage and promotes cross-pollination, thus increasing male fitness. In addition, in many heterostylous species selfing and the generation of unfit progeny due to inbreeding depression is limited by a self-incompatibility system, thus promoting female fitness. The two floral forms are genetically determined by the S locus as a complex supergene, namely a chromosomal region containing several individual genes that control the different traits, such as style or stamen length, and are held together by very tight linkage due to suppressed recombination. Recent molecular-genetic studies in several systems, including Turnera, Fagopyrum, Linum, and Primula have begun to identify and characterize the causal heterostyly genes residing at the S locus. An emerging theme from several families is that the dominant S haplotype represents a hemizygous region not present on the recessive s haplotype. This provides an explanation for the suppressed recombination and suggests a scenario for the chromosomal evolution of the S locus. In this review, we discuss the results from recent molecular-genetic analyses in light of the classical models on the genetics and evolution of heterostyly.}, language = {en} } @misc{KramerLenhard2017, author = {Kramer, Elena M. and Lenhard, Michael}, title = {Shape and form in plant development}, series = {Seminars in cell \& developmental biology}, volume = {79}, journal = {Seminars in cell \& developmental biology}, publisher = {Elsevier}, address = {London}, issn = {1084-9521}, doi = {10.1016/j.semcdb.2017.11.004}, pages = {1 -- 2}, year = {2017}, language = {en} } @misc{Lenhard2017, author = {Lenhard, Michael}, title = {Plant Development: Keeping on the Straight and Narrow and Flat}, series = {Current biology}, volume = {27}, journal = {Current biology}, publisher = {Cell Press}, address = {Cambridge}, issn = {0960-9822}, doi = {10.1016/j.cub.2017.10.030}, pages = {R1277 -- R1280}, year = {2017}, language = {en} } @article{Schneider2017, author = {Schneider, Hans Julius}, title = {Buddhist Meditation as a Mystical Practice}, series = {Philosophia : philosophical quarterly of Israel}, volume = {45}, journal = {Philosophia : philosophical quarterly of Israel}, publisher = {Springer}, address = {Dordrecht}, issn = {0048-3893}, doi = {10.1007/s11406-017-9925-x}, pages = {1621 -- 1622}, year = {2017}, abstract = {On the basis of many years of personal experience the paper describes Buddhist meditation (Zazen, Vipassanā) as a mystical practice. After a short discussion of the role of some central concepts (longing, suffering, and love) in Buddhism, William James' concept of religious experience is used to explain the goal of meditators as the achievement of a special kind of an experience of this kind. Systematically, its main point is to explain the difference between (on the one hand) a craving for pleasant 'mental events' in the sense of short-term moods, and (on the other) the long-term project of achieving a deep change in one's attitude to life as a whole, a change that allows the acceptance of suffering and death. The last part argues that there is no reason to call the discussed practice irrational in a negative sense. Changes of attitude of the discussed kind cannot be brought about by argument alone. Therefore, a considered use of age-old practices like meditation should be seen as an addition, not as an undermining of reason.}, language = {en} } @misc{LomadzeKopyshevBargheeretal.2017, author = {Lomadze, Nino and Kopyshev, Alexey and Bargheer, Matias and Wollgarten, Markus and Santer, Svetlana}, title = {Mass production of polymer nanowires filled with metal nanoparticles}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-402712}, pages = {10}, year = {2017}, abstract = {Despite the ongoing progress in nanotechnology and its applications, the development of strategies for connecting nano-scale systems to micro- or macroscale elements is hampered by the lack of structural components that have both, nano- and macroscale dimensions. The production of nano-scale wires with macroscale length is one of the most interesting challenges here. There are a lot of strategies to fabricate long nanoscopic stripes made of metals, polymers or ceramics but none is suitable for mass production of ordered and dense arrangements of wires at large numbers. In this paper, we report on a technique for producing arrays of ordered, flexible and free-standing polymer nano-wires filled with different types of nano-particles. The process utilizes the strong response of photosensitive polymer brushes to irradiation with UV-interference patterns, resulting in a substantial mass redistribution of the polymer material along with local rupturing of polymer chains. The chains can wind up in wires of nano-scale thickness and a length of up to several centimeters. When dispersing nano-particles within the film, the final arrangement is similar to a core-shell geometry with mainly nano-particles found in the core region and the polymer forming a dielectric jacket.}, language = {en} } @article{GuillemoteauLueckTronicke2017, author = {Guillemoteau, Julien and L{\"u}ck, Erika and Tronicke, Jens}, title = {1D inversion of direct current data acquired with a rolling electrode system}, series = {Journal of applied geophysics}, volume = {146}, journal = {Journal of applied geophysics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0926-9851}, doi = {10.1016/j.jappgeo.2017.09.010}, pages = {167 -- 177}, year = {2017}, abstract = {Direct current systems employing a kinematic surveying strategy allow to analyze the electrical resistivity of the subsurface for large areas (i.e., several hectares). Typical applications are found in precision agriculture, archaeological prospecting and soil sciences. With the typical survey setting, the collected data sets are often characterized by a rather high level of noise and a rather coarse lateral sampling compared to data acquired with fixed electrodes. We therefore present an efficient one-dimensional inversion approach in which we put special attention on modeling the effects of noise. We apply this method to data recorded with a five-offset equatorial dipole-dipole system employing rolling electrodes. By performing several synthetic tests with realistic noise levels, we found that the considered five-configuration soundings allow for a reliable imaging of two-layer cases in the uppermost two meters of the subsurface, where the subsurface can be assumed to follow a horizontally layered geometry within 3 m around the system. By analyzing the corresponding sensitivity functions, we also show that the equatorial dipole-dipole array is relatively well suited for a 1D inversion approach compared to standard in-line electrode arrays. To illustrate this aspect, we show that our method can provide results similar to those obtained with a 2D Wenner imaging procedure for data recorded across a well-constrained 2D target. We finally apply our method to a large five-offset data set acquired in an agricultural study. The final pseudo-3D model of electrical resistivity is in accordance with borehole data available for the surveyed area. Our results demonstrate the applicability and the versatility of the presented inversion approach for large-scale data sets as they are typically collected with such rolling electrode systems. (C) 2017 Elsevier B.V. All rights reserved.}, language = {en} } @article{GuillemoteauChristensenJacobsenetal.2017, author = {Guillemoteau, Julien and Christensen, Niels Boie and Jacobsen, Bo Holm and Tronicke, Jens}, title = {Fast 3D multichannel deconvolution of electromagnetic induction loop-loop apparent conductivity data sets acquired at low induction numbers}, series = {Geophysics}, volume = {82}, journal = {Geophysics}, publisher = {Society of Exploration Geophysicists}, address = {Tulsa}, issn = {0016-8033}, doi = {10.1190/GEO2016-0518.1}, pages = {E357 -- E369}, year = {2017}, abstract = {Electromagnetic induction (EMI) sensors using sufficiently low-frequency harmonic sources and sufficiently small loop separations operate in the low-induction-number (LIN) domain for a relatively wide range of background conductivity. These systems are used in diverse near-surface investigations including applications from soil sciences, hydrology, and archaeology. The special case of portable multiconfiguration EMI sensors operating at frequencies <= 20 kHz offers the possibility of using a fast linear deconvolution method to interpret multichannel data sets in three dimensions. Here, we have developed a fast 3D inversion/deconvolution method regularized with 3D smoothness constraints and formulated in the hybrid spectral-spatial domain. Compared with other linear approaches, the spectral-spatial domain formulation significantly reduces the computational cost of the processing and opens the door for real-time 3D interpretation of large data sets consisting of more than 100,000 data points. First, we test our proposed algorithm on synthetic data sets computed with the full Maxwell theory. Then, we apply our method to a real four-configuration EMI data set acquired to map the thickness of peat layers embedded in a sandy environment. For the synthetic and the field example, we compared our result with the result obtained using a standard point-by-point 1D nonlinear inversion approach. This comparison demonstrates that the proposed methodology provides superior lateral resolution compared with the 1D nonlinear inversion, at the same time significantly reducing the computational cost of the processing.}, language = {en} } @misc{GarcinAcostaMelnicketal.2017, author = {Garcin, Yannick and Acosta, Veronica Torres and Melnick, Daniel and Guillemoteau, Julien and Willenbring, Jane and Strecker, Manfred}, title = {Short-lived increase in erosion during the African Humid Period: Evidence from the northern Kenya Rift (vol 759, pg 58, 2017)}, series = {Earth \& planetary science letters}, volume = {474}, journal = {Earth \& planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2017.07.027}, pages = {528 -- 528}, year = {2017}, language = {en} } @article{AngermannJackischAllroggenetal.2017, author = {Angermann, Lisa and Jackisch, Conrad and Allroggen, Niklas and Sprenger, Matthias and Zehe, Erwin and Tronicke, Jens and Weiler, Markus and Blume, Theresa}, title = {Form and function in hillslope hydrology: characterization of subsurface flow based on response observations}, series = {Hydrology and earth system sciences : HESS}, volume = {21}, journal = {Hydrology and earth system sciences : HESS}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-21-3727-2017}, pages = {3727 -- 3748}, year = {2017}, abstract = {The phrase form and function was established in architecture and biology and refers to the idea that form and functionality are closely correlated, influence each other, and co-evolve. We suggest transferring this idea to hydrological systems to separate and analyze their two main characteristics: their form, which is equivalent to the spatial structure and static properties, and their function, equivalent to internal responses and hydrological behavior. While this approach is not particularly new to hydrological field research, we want to employ this concept to explicitly pursue the question of what information is most advantageous to understand a hydrological system. We applied this concept to subsurface flow within a hillslope, with a methodological focus on function: we conducted observations during a natural storm event and followed this with a hillslope-scale irrigation experiment. The results are used to infer hydrological processes of the monitored system. Based on these findings, the explanatory power and conclusiveness of the data are discussed. The measurements included basic hydrological monitoring methods, like piezometers, soil moisture, and discharge measurements. These were accompanied by isotope sampling and a novel application of 2-D time-lapse GPR (ground-penetrating radar). The main finding regarding the processes in the hillslope was that preferential flow paths were established quickly, despite unsaturated conditions. These flow paths also caused a detectable signal in the catchment response following a natural rainfall event, showing that these processes are relevant also at the catchment scale. Thus, we conclude that response observations (dynamics and patterns, i.e., indicators of function) were well suited to describing processes at the observational scale. Especially the use of 2-D time-lapse GPR measurements, providing detailed subsurface response patterns, as well as the combination of stream-centered and hillslope-centered approaches, allowed us to link processes and put them in a larger context. Transfer to other scales beyond observational scale and generalizations, however, rely on the knowledge of structures (form) and remain speculative. The complementary approach with a methodological focus on form (i.e., structure exploration) is presented and discussed in the companion paper by Jackisch et al. (2017).}, language = {en} } @article{JackischAngermannAllroggenetal.2017, author = {Jackisch, Conrad and Angermann, Lisa and Allroggen, Niklas and Sprenger, Matthias and Blume, Theresa and Tronicke, Jens and Zehe, Erwin}, title = {Form and function in hillslope hydrology: in situ imaging and characterization of flow-relevant structures}, series = {Hydrology and earth system sciences : HESS}, volume = {21}, journal = {Hydrology and earth system sciences : HESS}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-21-3749-2017}, pages = {3749 -- 3775}, year = {2017}, abstract = {The study deals with the identification and characterization of rapid subsurface flow structures through pedo- and geo-physical measurements and irrigation experiments at the point, plot and hillslope scale. Our investigation of flow-relevant structures and hydrological responses refers to the general interplay of form and function, respectively. To obtain a holistic picture of the subsurface, a large set of different laboratory, exploratory and experimental methods was used at the different scales. For exploration these methods included drilled soil core profiles, in situ measurements of infiltration capacity and saturated hydraulic conductivity, and laboratory analyses of soil water retention and saturated hydraulic conductivity. The irrigation experiments at the plot scale were monitored through a combination of dye tracer, salt tracer, soil moisture dynamics, and 3-D time-lapse ground penetrating radar (GPR) methods. At the hillslope scale the subsurface was explored by a 3-D GPR survey. A natural storm event and an irrigation experiment were monitored by a dense network of soil moisture observations and a cascade of 2-D time-lapse GPR "trenches". We show that the shift between activated and non-activated state of the flow paths is needed to distinguish structures from overall heterogeneity. Pedo-physical analyses of point-scale samples are the basis for sub-scale structure inference. At the plot and hillslope scale 3-D and 2-D time-lapse GPR applications are successfully employed as non-invasive means to image subsurface response patterns and to identify flow-relevant paths. Tracer recovery and soil water responses from irrigation experiments deliver a consistent estimate of response velocities. The combined observation of form and function under active conditions provides the means to localize and characterize the structures (this study) and the hydrological processes (companion study Angermann et al., 2017, this issue).}, language = {en} } @article{BoboneHilschStormetal.2017, author = {Bobone, Sara and Hilsch, Malte and Storm, Julian and Dunsing, Valentin and Herrmann, Andreas and Chiantia, Salvatore}, title = {Phosphatidylserine Lateral Organization Influences the Interaction of Influenza Virus Matrix Protein 1 with Lipid Membranes}, series = {Journal of virology}, volume = {91}, journal = {Journal of virology}, publisher = {American Society for Microbiology}, address = {Washington}, issn = {0022-538X}, doi = {10.1128/JVI.00267-17}, pages = {15}, year = {2017}, abstract = {Influenza A virus matrix protein 1 (M1) is an essential component involved in the structural stability of the virus and in the budding of new virions from infected cells. A deeper understanding of the molecular basis of virion formation and the budding process is required in order to devise new therapeutic approaches. We performed a detailed investigation of the interaction between M1 and phosphatidylserine (PS) (i.e., its main binding target at the plasma membrane [PM]), as well as the distribution of PS itself, both in model membranes and in living cells. To this end, we used a combination of techniques, including Forster resonance energy transfer (FRET), confocal microscopy imaging, raster image correlation spectroscopy, and number and brightness (N\&B) analysis. Our results show that PS can cluster in segregated regions in the plane of the lipid bilayer, both in model bilayers constituted of PS and phosphatidylcholine and in living cells. The viral protein M1 interacts specifically with PS-enriched domains, and such interaction in turn affects its oligomerization process. Furthermore, M1 can stabilize PS domains, as observed in model membranes. For living cells, the presence of PS clusters is suggested by N\&B experiments monitoring the clustering of the PS sensor lactadherin. Also, colocalization between M1 and a fluorescent PS probe suggest that, in infected cells, the matrix protein can specifically bind to the regions of PM in which PS is clustered. Taken together, our observations provide novel evidence regarding the role of PS-rich domains in tuning M1-lipid and M1-M1 interactions at the PM of infected cells. IMPORTANCE Influenza virus particles assemble at the plasma membranes (PM) of infected cells. This process is orchestrated by the matrix protein M1, which interacts with membrane lipids while binding to the other proteins and genetic material of the virus. Despite its importance, the initial step in virus assembly (i.e., M1-lipid interaction) is still not well understood. In this work, we show that phosphatidylserine can form lipid domains in physical models of the inner leaflet of the PM. Furthermore, the spatial organization of PS in the plane of the bilayer modulates M1-M1 interactions. Finally, we show that PS domains appear to be present in the PM of living cells and that M1 seems to display a high affinity for them.}, language = {en} } @article{GarcinSchildgenAcostaetal.2017, author = {Garcin, Yannick and Schildgen, Taylor F. and Acosta, Veronica Torres and Melnick, Daniel and Guillemoteau, Julien and Willenbring, Jane and Strecker, Manfred}, title = {Short-lived increase in erosion during the African Humid Period}, series = {Earth \& planetary science letters}, volume = {459}, journal = {Earth \& planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2016.11.017}, pages = {58 -- 69}, year = {2017}, abstract = {The African Humid Period (AHP) between similar to 15 and 5.5 cal. kyr BP caused major environmental change in East Africa, including filling of the Suguta Valley in the northern Kenya Rift with an extensive (similar to 2150 km(2)), deep (similar to 300 m) lake. Interfingering fluvio-lacustrine deposits of the Baragoi paleo-delta provide insights into the lake-level history and how erosion rates changed during this time, as revealed by delta-volume estimates and the concentration of cosmogenic Be-10 in fluvial sand. Erosion rates derived from delta-volume estimates range from 0.019 to 0.03 mm yr(-1). Be-10-derived paleo-erosion rates at similar to 11.8 cal. kyr BP ranged from 0.035 to 0.086 mm yr(-1), and were 2.7 to 6.6 times faster than at present. In contrast, at similar to 8.7 cal. kyr BP, erosion rates were only 1.8 times faster than at present. Because Be-10-derived erosion rates integrate over several millennia; we modeled the erosion-rate history that best explains the 10Be data using established non-linear equations that describe in situ cosmogenic isotope production and decay. Two models with different temporal constraints (15-6.7 and 12-6.7 kyr) suggest erosion rates that were 25 to 300 times higher than the initial erosion rate (pre-delta formation). That pulse of high erosion rates was short (similar to 4 kyr or less) and must have been followed by a rapid decrease in rates while climate remained humid to reach the modern Be-10-based erosion rate of,similar to 0.013 mm yr(-1). Our simulations also flag the two highest Be-10-derived erosion rates at 11.8 kyr BP related to nonuniform catchment erosion. These changes in erosion rates and processes during the AHP may reflect a strong increase in precipitation, runoff, and erosivity at the arid-to-humid transition either at 15 or similar to 12 cal. kyr BP, before the landscape stabilized again, possibly due to increased soil production and denser vegetation.}, language = {en} } @article{TronickePaasche2017, author = {Tronicke, Jens and Paasche, Hendrik}, title = {Integrated interpretation of 2D ground-penetrating radar, P-, and S-wave velocity models in terms of petrophysical properties}, series = {Interpretation : a journal of subsurface characterization}, volume = {5}, journal = {Interpretation : a journal of subsurface characterization}, number = {1}, publisher = {Society of Exploration Geophysicists}, address = {Tulsa}, issn = {2324-8858}, doi = {10.1190/INT-2016-0081.1}, pages = {T121 -- T130}, year = {2017}, abstract = {Near-surface geophysical techniques are extensively used in a variety of engineering, environmental, geologic, and hydrologic applications. While many of these applications ask for detailed, quantitative models of selected material properties, geophysical data are increasingly used to estimate such target properties. Typically, this estimation procedure relies on a two-step workflow including (1) the inversion of geophysical data and (2) the petrophysical translation of the inverted parameter models into the target properties. Standard deterministic implementations of such a quantitative interpretation result in a single best-estimate model, often without considering and propagating the uncertainties related to the two steps. We address this problem by using a rather novel, particle-swarm-based global joint strategy for data inversion and by implementing Monte Carlo procedures for petrophysical property estimation. We apply our proposed workflow to crosshole ground-penetrating radar, P-, and S-wave data sets collected at a well-constrained test site for a detailed geotechnical characterization of unconsolidated sands. For joint traveltime inversion, the chosen global approach results in ensembles of acceptable velocity models, which are analyzed to appraise inversion-related uncertainties. Subsequently, the entire ensembles of inverted velocity models are considered to estimate selected petrophysical properties including porosity, bulk density, and elastic moduli via well-established petrophysical relations implemented in a Monte Carlo framework. Our results illustrate the potential benefit of such an advanced interpretation strategy; i.e., the proposed workflow allows to study how uncertainties propagate into the finally estimated property models, while concurrently we are able to study the impact of uncertainties in the used petrophysical relations (e.g., the influence of uncertain, user-specified parameters). We conclude that such statistical approaches for the quantitative interpretation of geophysical data can be easily extended and adapted to other applications and geophysical methods and might be an important step toward increasing the popularity and acceptance of geophysical tools in engineering practice.}, language = {en} } @article{AttermeyerGrossartFluryetal.2017, author = {Attermeyer, Katrin and Grossart, Hans-Peter and Flury, Sabine and Premke, Katrin}, title = {Bacterial processes and biogeochemical changes in the water body of kettle holes - mainly driven by autochthonous organic matter?}, series = {Aquatic sciences : research across boundaries}, volume = {79}, journal = {Aquatic sciences : research across boundaries}, publisher = {Springer}, address = {Basel}, issn = {1015-1621}, doi = {10.1007/s00027-017-0528-1}, pages = {675 -- 687}, year = {2017}, abstract = {Kettle holes are small inland waters formed from glacially-created depressions often situated in agricultural landscapes. Due to their high perimeter-to-area ratio facilitating a high aquatic-terrestrial coupling, kettle holes can accumulate high concentrations of organic carbon and nutrients, fueling microbial activities and turnover rates. Thus, they represent hotspots of carbon turnover in the landscape, but their bacterial activities and controlling factors have not been well investigated. Therefore, we aimed to assess the relative importance of various environmental factors on bacterial and biogeochemical processes in the water column of kettle holes and to disentangle their variations. In the water body of ten kettle holes in north-eastern Germany, we measured several physico-chemical and biological parameters such as carbon quantity and quality, as well as bacterial protein production (BP) and community respiration (CR) in spring, early summer and autumn 2014. Particulate organic matter served as an indicator of autochthonous production and represented an important parameter to explain variations in BP and CR. This notion is supported by qualitative absorbance indices of dissolved molecules in water samples and C: N ratios of the sediments, which demonstrate high fractions of autochthonous organic matter (OM) in the studied kettle holes. In contrast, dissolved chemical parameters were less important for bacterial activities although they revealed strong differences throughout the growing season. Pelagic bacterial activities and dynamics might thus be regulated by autochthonous OM in kettle holes implying a control of important biogeochemical processes by internal primary production rather than facilitated exchange with the terrestrial surrounding due to a high perimeter-to-area ratio.}, language = {en} } @article{TaubeGanzertGrossartetal.2017, author = {Taube, Robert and Ganzert, Lars and Grossart, Hans-Peter and Gleixner, Gerd and Premke, Katrin}, title = {Organic matter quality structures benthic fatty acid patterns and the abundance of fungi and bacteria in temperate lakes}, series = {The science of the total environment : an international journal for scientific research into the environment and its relationship with man}, volume = {610}, journal = {The science of the total environment : an international journal for scientific research into the environment and its relationship with man}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0048-9697}, doi = {10.1016/j.scitotenv.2017.07.256}, pages = {469 -- 481}, year = {2017}, abstract = {Benthic microbial communities (BMCs) play important roles in the carbon cycle of lakes, and benthic littoral zones in particular have been previously highlighted as biogeochemical hotspots. Dissolved organic matter (DOM) presents the major carbon pool in lakes, and although the effect of DOM composition on the pelagic microbial community composition is widely accepted, little is known about its effect on BMCs, particularly aquatic fungi. Therefore, we investigated the composition of benthic littoral microbial communities in twenty highly diverse lakes in northeast Germany. DOM quality was analyzed via size exclusion chromatography (SEC), fluorescence parallel factor analyses (PRAFACs) and UV-Vis spectroscopy. We determined the BMC composition and biomass using phospholipid-derived fatty acids (PLFA) and extended the interpretation to the analysis of fungi by applying a Bayesian mixed model. We present evidence that the quality of DOM structures the BMCs, which are dominated by heterotrophic bacteria and show low fungal biomass. The fungal biomass increases when the DOM pool is processed by microorganisms of allochthonous origin, whereas the opposite is true for bacteria.}, language = {en} } @article{AbdallaAbramowskiAharonianetal.2017, author = {Abdalla, Hassan E. and Abramowski, Attila and Aharonian, Felix A. and Benkhali, Faical Ait and Akhperjanian, A. G. and Andersson, T. and Anguner, Ekrem Oǧuzhan and Arakawa, M. and Arrieta, M. and Aubert, Pierre and Backes, Michael and Balzer, Arnim and Barnard, Michelle and Becherini, Yvonne and Tjus, J. Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, K. and Blackwell, R. and B{\"o}ttcher, Markus and Boisson, Catherine and Bolmont, J. and Bonnefoy, S. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Buechele, M. and Bulik, Tomasz and Capasso, M. and Carr, John and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chaves, Ryan C. G. and Chen, Andrew and Chevalier, J. and Coffaro, M. and Colafrancesco, Sergio and Cologna, Gabriele and Condon, B. and Conrad, Jan and Cui, Y. and Davids, I. D. and Decock, J. and Degrange, B. and Deil, C. and Devin, J. and de Wilt, P. and Dirson, L. and Djannati-Atai, A. and Domainko, W. and Donath, A. and Dutson, K. and Dyks, J. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, S. and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Foerster, A. and Funk, S. and Fuessling, M. and Gabici, S. and Gallant, Y. A. and Garrigoux, T. and Giavitto, G. and Giebels, B. and Glicenstein, J. F. and Gottschall, D. and Goyal, A. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hawkes, J. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, James Anthony and Hofmann, W. and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Ivascenko, A. and Iwasaki, H. and Jacholkowska, A. and Jamrozy, M. and Janiak, M. and Jankowsky, D. and Jankowsky, F. and Jingo, M. and Jogler, T. and Jouvin, L. and Jung-Richardt, I. and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Kerszberg, D. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Klochkov, D. and Kluzniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, M. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, J. and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, T. and Lorentz, M. and Liu, R. and Lopez-Coto, R. and Lypova, I. and Marandon, V. and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, M. and Meintjes, P. J. and Meyer, M. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Mora, K. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and de Naurois, M. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Ostrowski, M. and Oya, I. and Padovani, M. and Panter, M. and Parsons, R. D. and Pekeur, N. W. and Pelletier, G. and Perennes, C. and Petrucci, P. -O. and Peyaud, B. and Piel, Q. and Pita, S. and Poon, H. and Prokhorov, D. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Renaud, M. and de los Reyes, R. and Richter, S. and Rieger, F. and Romoli, C. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Saito, S. and Salek, D. and Sanchez, David M. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Settimo, M. and Seyffert, A. S. and Shafi, N. and Shilon, I. and Simoni, R. and Sol, H. and Spanier, F. and Spengler, G. and Spies, F. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Stycz, K. and Sushch, Iurii and Takahashi, T. and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tibaldo, L. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, R. and Zaborov, D. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Zefi, F. and Ziegler, A. and Zywucka, N.}, title = {Measurement of the EBL spectral energy distribution using the VHE gamma-ray spectra of HESS blazars}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {606}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201731200}, pages = {11}, year = {2017}, abstract = {Very high-energy gamma rays (VHE, E greater than or similar to 100 GeV) propagating over cosmological distances can interact with the low-energy photons of the extragalactic background light (EBL) and produce electron-positron pairs. The transparency of the Universe to VHE gamma rays is then directly related to the spectral energy distribution (SED) of the EBL. The observation of features in the VHE energy spectra of extragalactic sources allows the EBL to be measured, which otherwise is very difficult. An EBL model-independent measurement of the EBL SED with the H.E.S.S. array of Cherenkov telescopes is presented. It was obtained by extracting the EBL absorption signal from the reanalysis of high-quality spectra of blazars. From H.E.S.S. data alone the EBL signature is detected at a significance of 9.5 sigma, and the intensity of the EBL obtained in different spectral bands is presented together with the associated gamma-ray horizon.}, language = {en} } @article{AbdallaAbramowskiAharonianetal.2017, author = {Abdalla, Hassan E. and Abramowski, Attila and Aharonian, Felix A. and Benkhali, Faical Ait and Anguner, Ekrem Oǧuzhan and Arakawa, M. and Arrieta, M. and Aubert, Pierre and Backes, Michael and Balzer, Arnim and Barnard, Michelle and Becherini, Yvonne and Tjus, J. Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, K. and Blackwell, R. and B{\"o}ttcher, Markus and Boisson, Catherine and Bolmont, J. and Bonnefoy, S. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Buechele, M. and Bulik, Tomasz and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chaves, Ryan C. G. and Chen, Andrew and Chevalier, J. and Colafrancesco, Sergio and Condon, B. and Conrad, Jan and Davids, I. D. and Decock, J. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Donath, A. and Dutson, K. and Dyks, J. and Edwards, T. and Egberts, Kathrin and Emery, G. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, S. and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Funk, S. and Fuessling, M. and Gabici, S. and Gallant, Y. A. and Garrigoux, T. and Gate, F. and Giavitto, G. and Giebels, B. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hawkes, J. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, James Anthony and Hofmann, W. and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Ivascenko, A. and Iwasaki, H. and Jacholkowska, A. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jingo, M. and Jouvin, L. and Jung-Richardt, I. and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Kerszberg, D. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Klochkov, D. and Kluzniak, W. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, M. and Kruer, P. P. and Laffon, H. and Lamanna, G. and Lau, J. and Lees, J. -P. and Lefaucheur, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, T. and Lorentz, M. and Liu, R. and Lopez-Coto, R. and Lypova, I. and Malyshev, D. and Marandon, V. and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, M. and Meintjes, P. J. and Meyer, M. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Mora, K. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Ostrowski, M. and Oya, I. and Padovani, M. and Panter, M. and Parsons, R. D. and Pekeur, N. W. and Pelletier, G. and Perennes, C. and Petrucci, P. -O. and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V. and Poon, H. and Prokhorov, D. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Renaud, M. and de los Reyes, R. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Saito, S. and Sanchez, David M. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Settimo, M. and Seyffert, A. S. and Shafi, N. and Shilon, I. and Shiningayamwe, K. and Simoni, R. and Sol, H. and Spanier, F. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Sushch, Iurii and Takahashi, T. and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tibaldo, L. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, R. and Zaborov, D. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Zefi, F. and Ziegler, A. and Zorn, J. and Zywucka, N.}, title = {TeV Gamma-Ray Observations of the Binary Neutron Star Merger GW170817 with HESS}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, volume = {850}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, organization = {HESS Collaboration}, issn = {2041-8205}, doi = {10.3847/2041-8213/aa97d2}, pages = {628 -- 650}, year = {2017}, abstract = {We search for high-energy gamma-ray emission from the binary neutron star merger GW170817 with the H.E.S.S. Imaging Air Cherenkov Telescopes. The observations presented here have been obtained starting only 5.3 hr after GW170817. The H.E.S.S. target selection identified regions of high probability to find a counterpart of the gravitational-wave event. The first of these regions contained the counterpart SSS17a that has been identified in the optical range several hours after our observations. We can therefore present the first data obtained by a ground-based pointing instrument on this object. A subsequent monitoring campaign with the H.E.S.S. telescopes extended over several days, covering timescales from 0.22 to 5.2 days and energy ranges between 270 GeV to 8.55 TeV. No significant gamma-ray emission has been found. The derived upper limits on the very-high-energy gamma-ray flux for the first time constrain non-thermal, high-energy emission following the merger of a confirmed binary neutron star system.}, language = {en} } @phdthesis{Mengler2017, author = {Mengler, Till}, title = {Die l{\"u}ckenhafte Beweisw{\"u}rdigung im tatgerichtlichen Urteil}, series = {Studien zum Strafrecht ; 82}, journal = {Studien zum Strafrecht ; 82}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-3986-8}, school = {Universit{\"a}t Potsdam}, pages = {173}, year = {2017}, abstract = {Die Beweisw{\"u}rdigung gilt traditionell als „Dom{\"a}ne des Tatrichters". Inzwischen untersuchen die Revisionsgerichte tatgerichtliche Urteile allerdings verst{\"a}rkt auf sogenannte Beweisw{\"u}rdigungsfehler. Besonders h{\"a}ufig wird hierbei „L{\"u}ckenhaftigkeit" moniert. Die Konturen dieses Fehlertyps sind jedoch schwach; ebenso wenig wurde bislang das strukturelle Verh{\"a}ltnis zu den {\"u}brigen Fehlertypen herausgearbeitet. Der Verfasser n{\"a}hert sich dem Problemkreis deduktiv, ausgehend vom verr{\"a}umlichten Verst{\"a}ndnis der Beweisw{\"u}rdigung als dem Versuch, die L{\"u}cke zwischen Prozess- und Tatgeschehen zu schließen. Die Untersuchung f{\"u}hrt an die erkenntnistheoretischen wie auch normativen Grenzen dieses Schließverfahrens und verdeutlicht, dass die L{\"u}cke auch unter Idealbedingungen rational nur verkleinert, nicht aber geschlossen werden kann. Anschließend tritt der Verfasser der herrschenden Auffassung entgegen, die f{\"u}r die {\"U}berzeugungsbildung eine subjektiv-irrationale {\"U}berwindung objektiv-rationaler Ungewissheit fordert. Aus alldem entwickelt er schließlich ein Konzept der l{\"u}ckenhaften Beweisw{\"u}rdigung. Die Arbeit wurde mit dem Wolf-R{\"u}diger-Bub-Preis ausgezeichnet.}, language = {de} } @misc{ReilRosenfeldImholtetal.2017, author = {Reil, Daniela and Rosenfeld, Ulrike and Imholt, Christian and Schmidt, Sabrina and Ulrich, Rainer G. and Eccard, Jana and Jacob, Jens}, title = {Puumala hantavirus infections in bank vole populations}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {957}, issn = {1866-8372}, doi = {10.25932/publishup-43123}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431232}, pages = {15}, year = {2017}, abstract = {Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk.}, language = {en} } @article{NietzscheGuerraAlseekhetal.2017, author = {Nietzsche, Madlen and Guerra, Tiziana and Alseekh, Saleh and Wiermer, Marcel and Sonnewald, Sophia and Fernie, Alisdair R. and B{\"o}rnke, Frederik}, title = {STOREKEEPER RELATED1/G-Element Binding Protein (STKR1) Interacts with Protein Kinase SnRK1}, series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants}, volume = {176}, journal = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants}, number = {2}, publisher = {American Society of Plant Physiologists}, address = {Rockville}, issn = {0032-0889}, doi = {10.1104/pp.17.01461}, pages = {1773 -- 1792}, year = {2017}, abstract = {Sucrose nonfermenting related kinase1 (SnRK1) is a conserved energy sensor kinase that regulates cellular adaptation to energy deficit in plants. Activation of SnRK1 leads to the down-regulation of ATP-consuming biosynthetic processes and the stimulation of energy-generating catabolic reactions by transcriptional reprogramming and posttranslational modifications. Although considerable progress has been made during the last years in understanding the SnRK1 signaling pathway, many of its components remain unidentified. Here, we show that the catalytic alpha-subunits KIN10 and KIN11 of the Arabidopsis (Arabidopsis thaliana) SnRK1 complex interact with the STOREKEEPER RELATED1/G-Element Binding Protein (STKR1) inside the plant cell nucleus. Overexpression of STKR1 in transgenic Arabidopsis plants led to reduced growth, a delay in flowering, and strongly attenuated senescence. Metabolite profiling revealed that the transgenic lines exhausted their carbohydrates during the dark period to a greater extent than the wild type and accumulated a range of amino acids. At the global transcriptome level, genes affected by STKR1 overexpression were broadly associated with systemic acquired resistance, and transgenic plants showed enhanced resistance toward a virulent strain of the biotrophic oomycete pathogen Hyaloperonospora arabidopsidis Noco2. We discuss a possible connection of STKR1 function, SnRK1 signaling, and plant immunity.}, language = {en} } @article{BohlkenJacobSchaumetal.2017, author = {Bohlken, Jens and Jacob, Louis and Schaum, Peter and Rapp, Michael A. and Kostev, Karel}, title = {Hip fracture risk in patients with dementia in German primary care practices}, series = {Dementia}, volume = {16}, journal = {Dementia}, publisher = {Sage Publ.}, address = {London}, issn = {1471-3012}, doi = {10.1177/1471301215621854}, pages = {853 -- 864}, year = {2017}, abstract = {The aim was to analyze the risk of hip fracture in German primary care patients with dementia. This study included patients aged 65-90 from 1072 primary care practices who were first diagnosed with dementia between 2010 and 2013. Controls were matched (1:1) to cases for age, sex, and type of health insurance. The primary outcome was the diagnosis of hip fracture during the three-year follow-up period. A total of 53,156 dementia patients and 53,156 controls were included. A total of 5.3\% of patients and 0.7\% of controls displayed hip fracture after three years. Hip fracture occurred more frequently in dementia subjects living in nursing homes than in those living at home (9.2\% versus 4.3\%). Dementia, residence in nursing homes, and osteoporosis were risk factors for fracture development. Antidementia, antipsychotic, and antidepressant drugs generally had no significant impact on hip fracture risk when prescribed for less than six months. Dementia increased hip fracture risk in German primary care practices.}, language = {en} } @article{StelzelSchauenburgRappetal.2017, author = {Stelzel, Christine and Schauenburg, Gesche and Rapp, Michael A. and Heinzel, Stephan and Granacher, Urs}, title = {Age-Related Interference between the Selection of Input-Output Modality Mappings and Postural Control}, series = {Frontiers in psychology}, volume = {8}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2017.00613}, year = {2017}, abstract = {Age-related decline in executive functions and postural control due to degenerative processes in the central nervous system have been related to increased fall-risk in old age. Many studies have shown cognitive-postural dual-task interference in old adults, but research on the role of specific executive functions in this context has just begun. In this study, we addressed the question whether postural control is impaired depending on the coordination of concurrent response-selection processes related to the compatibility of input and output modality mappings as compared to impairments related to working-memory load in the comparison of cognitive dual and single tasks. Specifically, we measured total center of pressure (CoP) displacements in healthy female participants aged 19-30 and 66-84 years while they performed different versions of a spatial one-back working memory task during semi-tandem stance on an unstable surface (i.e., balance pad) while standing on a force plate. The specific working-memory tasks comprised: (i) modality compatible single tasks (i.e., visual-manual or auditory-vocal tasks), (ii) modality compatible dual tasks (i.e., visual-manual and auditory-vocal tasks), (iii) modality incompatible single tasks (i.e., visual-vocal or auditory-manual tasks), and (iv) modality incompatible dual tasks (i.e., visual-vocal and auditory-manual tasks). In addition, participants performed the same tasks while sitting. As expected from previous research, old adults showed generally impaired performance under high working-memory load (i.e., dual vs. single one-back task). In addition, modality compatibility affected one-back performance in dual-task but not in single-task conditions with strikingly pronounced impairments in old adults. Notably, the modality incompatible dual task also resulted in a selective increase in total CoP displacements compared to the modality compatible dual task in the old but not in the young participants. These results suggest that in addition to effects of working-memory load, processes related to simultaneously overcoming special linkages between input- and output modalities interfere with postural control in old but not in young female adults. Our preliminary data provide further evidence for the involvement of cognitive control processes in postural tasks.}, language = {en} } @article{DeekenHaeuslerNordheimetal.2017, author = {Deeken, Friederike and H{\"a}usler, Andreas and Nordheim, Johanna and Rapp, Michael A. and Knoll, Nina and Rieckmann, Nina}, title = {Psychometric properties of the Perceived Stress Scale in a sample of German dementia patients and their caregivers}, series = {International psychogeriatrics}, volume = {30}, journal = {International psychogeriatrics}, number = {1}, publisher = {Cambridge Univ. Press}, address = {New York}, issn = {1041-6102}, doi = {10.1017/S1041610217001387}, pages = {39 -- 47}, year = {2017}, abstract = {Background: The aim of the present study was to investigate the psychometric characteristics of the Perceived Stress Scale (PSS) in a sample of dementia patients and their spousal caregivers. Methods: We investigated the reliability and validity of the 14-item PSS in a sample of 80 couples, each including one spouse who had been diagnosed with mild to moderate dementia (mean age 75.55, SD = 5.85, 38.7\% female) and one spousal caregiver (mean age 73.06, SD = 6.75, 61.3\% female). We also examined the factor structure and sensitivity of the scale with regard to gender differences. Results: Exploratory factor analysis of the PSS revealed a two-factor solution for the scale; the first factor reflected general stress while the second factor consisted of items reflecting the perceived ability to cope with stressors. A confirmatory factor analysis verified that the data were a better fit for the two-factor model than a one-factor model. The two factors of the PSS showed good reliability for patients as well as for caregivers ranging between alpha = 0.73 and alpha = 0.82. Perceived stress was significantly positively correlated with depressive symptomatology in both caregivers and patients. Mean PSS scores did not significantly differ between male and female patients nor did they differ between male and female caregivers. Conclusion: The present data indicate that the PSS provides a reliable and valid measure of perceived stress in dementia patients and their caregivers.}, language = {en} } @article{GellertHaeuslerGholamietal.2017, author = {Gellert, Paul and H{\"a}usler, Andreas and Gholami, Maryam and Rapp, Michael A. and Kuhlmey, Adelheid and Nordheim, Johanna}, title = {Own and partners' dyadic coping and depressive symptoms in individuals with early-stage dementia and their caregiving partners}, series = {Aging \& Mental Health}, volume = {22}, journal = {Aging \& Mental Health}, number = {8}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1360-7863}, doi = {10.1080/13607863.2017.1334759}, pages = {1008 -- 1016}, year = {2017}, abstract = {Objectives: In patients with early-stage dementia and their caregiving partners, reciprocal dyadic coping (DC) is crucial for preventing or reducing depressive symptoms in both partners. This study examines the relationships between 'own DC' and 'perceived partner DC' with depressive symptoms in couples coping with dementia on individual (actor effects) and cross-person (partner effects) levels. Method: 164 individuals (82 patients with early-stage dementia and their 82 caregiving partners; ND = 82 dyads) participated in this prospective study with measures (DC, depressive symptoms, and dementia severity) taken at baseline and at six months. Each partner evaluated their own and the perceived partner DC. Actor-partner interdependence models were applied to the resulting four independent evaluations. Results: Results differed substantially between patients and caregivers. DC was significantly related to patients' but not to caregivers' depressive symptoms, when adjustments were made for individual coping. Perceived partner DC showed a negative association with depressive symptoms in patients, whereas own DC was adversely related for actor as well as for partner effects across individuals. Conclusion: The adverse association between the own DC of the caregiver and the patient on depressive symptoms of the patient might be due to inappropriate efforts or to the loss of autonomy as a care-receiver. DC is important in both patients and caregivers, as shown by the negative association between perceived partner DC and depressive symptoms in the patients, which might inform interventions that target the couple as a whole.}, language = {en} } @article{HeinzelRappFydrichetal.2017, author = {Heinzel, Stephan and Rapp, Michael A. and Fydrich, Thomas and Str{\"o}hle, Andreas and Teran, Christina and Kallies, Gunnar and Schwefel, Melanie and Heissel, Andreas}, title = {Neurobiological mechanisms of exercise and psychotherapy in depression}, series = {Clinical Trials}, volume = {15}, journal = {Clinical Trials}, number = {1}, publisher = {Sage Publ.}, address = {London}, issn = {1740-7745}, doi = {10.1177/1740774517729161}, pages = {53 -- 64}, year = {2017}, abstract = {Background/Aims: Even though cognitive behavioral therapy has become a relatively effective treatment for major depressive disorder and cognitive behavioral therapy-related changes of dysfunctional neural activations were shown in recent studies, remission rates still remain at an insufficient level. Therefore, the implementation of effective augmentation strategies is needed. In recent meta-analyses, exercise therapy (especially endurance exercise) was reported to be an effective intervention in major depressive disorder. Despite these findings, underlying mechanisms of the antidepressant effect of exercise especially in combination with cognitive behavioral therapy have rarely been studied to date and an investigation of its neural underpinnings is lacking. A better understanding of the psychological and neural mechanisms of exercise and cognitive behavioral therapy would be important for developing optimal treatment strategies in depression. The SPeED study (Sport/Exercise Therapy and Psychotherapyevaluating treatment Effects in Depressive patients) is a randomized controlled trial to investigate underlying physiological, neurobiological, and psychological mechanisms of the augmentation of cognitive behavioral therapy with endurance exercise. It is investigated if a preceding endurance exercise program will enhance the effect of a subsequent cognitive behavioral therapy. Methods: This study will include 105 patients diagnosed with a mild or moderate depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders (4th ed.). The participants are randomized into one of three groups: a high-intensive or a low-intensive endurance exercise group or a waiting list control group. After the exercise program/waiting period, all patients receive an outpatient cognitive behavioral therapy treatment according to a standardized therapy manual. At four measurement points, major depressive disorder symptoms (Beck Depression Inventory, Hamilton Rating Scale for Depression), (neuro)biological measures (neural activations during working memory, monetary incentive delay task, and emotion regulation, as well as cortisol levels and brain-derived neurotrophic factor), neuropsychological test performance, and questionnaires (psychological needs, self-efficacy, and quality of life) are assessed. Results: In this article, we report the design of the SPeED study and refer to important methodological issues such as including both high- and low-intensity endurance exercise groups to allow the investigation of dose-response effects and physiological components of the therapy effects. Conclusion: The main aims of this research project are to study effects of endurance exercise and cognitive behavioral therapy on depressive symptoms and to investigate underlying physiological and neurobiological mechanisms of these effects. Results may provide important implications for the development of effective treatment strategies in major depressive disorder, specifically concerning the augmentation of cognitive behavioral therapy by endurance exercise.}, language = {en} } @misc{ChaparroZechHeinzeletal.2017, author = {Chaparro, Camilo G. A. Perez and Zech, Philipp A. and Heinzel, Stephan and Mayer, Frank and Wolfarth, Bernd and Rapp, Michael A. and Heissel, Andreas}, title = {Effects Of Aerobic \& Resistance Training On Cardiorespiratory Fitness In People Living with HIV. A Meta-analysis}, series = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, volume = {49}, journal = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0195-9131}, doi = {10.1249/01.mss.0000519265.28705.86}, pages = {842 -- 842}, year = {2017}, language = {en} } @phdthesis{Konrad2017, author = {Konrad, Marcel}, title = {Ermittlung der Depressionsinzidenz bei Patienten mit Herzinsuffizienz und koronarer Herzkrankheit sowie der medikament{\"o}sen Depressionstherapie bei Patienten mit kardiovaskul{\"a}ren Erkrankungen in der ambulanten Versorgung in Deutschland}, school = {Universit{\"a}t Potsdam}, year = {2017}, language = {de} } @article{KocReinhardtReppertetal.2017, author = {Koc, Azize and Reinhardt, M. and Reppert, Alexander von and Roessle, Matthias and Leitenberger, Wolfram and Dumesnil, K. and Gaal, Peter and Zamponi, Flavio and Bargheer, Matias}, title = {Ultrafast x-ray diffraction thermometry measures the influence of spin excitations on the heat transport through nanolayers}, series = {Physical review : B, Condensed matter and materials physics}, volume = {96}, journal = {Physical review : B, Condensed matter and materials physics}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9950}, doi = {10.1103/PhysRevB.96.014306}, pages = {7}, year = {2017}, abstract = {We investigate the heat transport through a rare earth multilayer system composed of yttrium (Y), dysprosium (Dy), and niobium (Nb) by ultrafast x-ray diffraction. This is an example of a complex heat flow problem on the nanoscale, where several different quasiparticles carry the heat and conserve a nonequilibrium for more than 10 ns. The Bragg peak positions of each layer represent layer-specific thermometers that measure the energy flow through the sample after excitation of the Y top layer with fs-laser pulses. In an experiment-based analytic solution to the nonequilibrium heat transport problem, we derive the individual contributions of the spins and the coupled electron-lattice system to the heat conduction. The full characterization of the spatiotemporal energy flow at different starting temperatures reveals that the spin excitations of antiferromagnetic Dy speed up the heat transport into the Dy layer at low temperatures, whereas the heat transport through this layer and further into the Y and Nb layers underneath is slowed down. The experimental findings are compared to the solution of the heat equation using macroscopic temperature-dependent material parameters without separation of spin and phonon contributions to the heat. We explain why the simulated energy density matches our experiment-based derivation of the heat transport, although the simulated thermoelastic strain in this simulation is not even in qualitative agreement.}, language = {en} } @article{FriedelSeboldKuitunenPauletal.2017, author = {Friedel, Eva and Sebold, Miriam and Kuitunen-Paul, S{\"o}ren and Nebe, Stephan and Veer, Ilya M. and Zimmermann, Ulrich S. and Schlagenhauf, Florian and Smolka, Michael N. and Rapp, Michael A. and Walter, Henrik and Heinz, Andreas}, title = {How Accumulated Real Life Stress Experience and Cognitive Speed Interact on Decision-Making Processes}, series = {Frontiers in human neuroscienc}, volume = {11}, journal = {Frontiers in human neuroscienc}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2017.00302}, pages = {1 -- 9}, year = {2017}, abstract = {Rationale: Advances in neurocomputational modeling suggest that valuation systems for goal-directed (deliberative) on one side, and habitual (automatic) decision-making on the other side may rely on distinct computational strategies for reinforcement learning, namely model-free vs. model-based learning. As a key theoretical difference, the model-based system strongly demands cognitive functions to plan actions prospectively based on an internal cognitive model of the environment, whereas valuation in the model-free system relies on rather simple learning rules from operant conditioning to retrospectively associate actions with their outcomes and is thus cognitively less demanding. Acute stress reactivity is known to impair model-based but not model-free choice behavior, with higher working memory capacity protecting the model-based system from acute stress. However, it is not clear which impact accumulated real life stress has on model-free and model-based decision systems and how this influence interacts with cognitive abilities. Methods: We used a sequential decision-making task distinguishing relative contributions of both learning strategies to choice behavior, the Social Readjustment Rating Scale questionnaire to assess accumulated real life stress, and the Digit Symbol Substitution Test to test cognitive speed in 95 healthy subjects. Results: Individuals reporting high stress exposure who had low cognitive speed showed reduced model-based but increased model-free behavioral control. In contrast, subjects exposed to accumulated real life stress with high cognitive speed displayed increased model-based performance but reduced model-free control. Conclusion: These findings suggest that accumulated real life stress exposure can enhance reliance on cognitive speed for model-based computations, which may ultimately protect the model-based system from the detrimental influences of accumulated real life stress. The combination of accumulated real life stress exposure and slower information processing capacities, however, might favor model-free strategies. Thus, the valence and preference of either system strongly depends on stressful experiences and individual cognitive capacities.}, language = {en} } @article{DrosselmeyerJacobRathmannetal.2017, author = {Drosselmeyer, Julia and Jacob, Louis and Rathmann, Wolfgang and Rapp, Michael A. and Kostev, Karel}, title = {Depression risk in patients with late-onset rheumatoid arthritis in Germany}, series = {Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation}, volume = {26}, journal = {Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation}, number = {2}, publisher = {Springer}, address = {Dordrecht}, issn = {0962-9343}, doi = {10.1007/s11136-016-1387-2}, pages = {437 -- 443}, year = {2017}, abstract = {The goal of this study was to determine the prevalence of depression and its risk factors in patients with late-onset rheumatoid arthritis (RA) treated in German primary care practices. Longitudinal data from general practices (n=1072) throughout Germany were analyzed. Individuals initially diagnosed with RA (2009-2013) were identified, and 7301 patients were included and matched (1:1) to 7301 controls. The primary outcome measure was the initial diagnosis of depression within 5 years after the index date in patients with and without RA. Cox proportional hazards models were used to adjust for confounders. The mean age was 72.2 years (SD: 7.6 years). A total of 34.9 \% of patients were men. Depression diagnoses were present in 22.0 \% of the RA group and 14.3 \% of the control group after a 5-year follow-up period (p < 0.001). In the multivariate regression model, RA was a strong risk factor for the development of depression (HR: 1.55, p < 0.001). There was significant interaction of RA and diagnosed inflammatory polyarthropathies (IP) (RA*IP interaction: p < 0.001). Furthermore, dementia, cancer, osteoporosis, hypertension, and diabetes were associated with a higher risk of developing depression (p values < 0.001). The risk of depression is significantly higher in patients with late-onset RA than in patients without RA for subjects treated in primary care practices in Germany. RA patients should be screened routinely for depression in order to ensure improved treatment and management.}, language = {en} } @misc{SeboldNebeGarbusowetal.2017, author = {Sebold, Miriam and Nebe, Stephan and Garbusow, Maria and Schad, Daniel and Sommer, Christian and Rapp, Michael A. and Smolka, Michael N. and Huys, Quentin J. M. and Schlagenhauf, Florian and Heinz, Andreas}, title = {Neurobiological correlates of learning and decision-making in alcohol dependence}, series = {European psychiatry : the journal of the Association of European Psychiatrists}, volume = {41}, journal = {European psychiatry : the journal of the Association of European Psychiatrists}, publisher = {Elsevier}, address = {Paris}, issn = {0924-9338}, doi = {10.1016/j.eurpsy.2017.01.084}, pages = {S11 -- S11}, year = {2017}, language = {en} } @article{StelzelSchauenburgRappetal.2017, author = {Stelzel, Christine and Schauenburg, Gesche and Rapp, Michael A. and Heinzel, Stephan and Granacher, Urs}, title = {Age-Related Interference between the Selection of Input-Output Modality Mappings and Postural Control-a Pilot Study}, series = {Frontiers in psychology}, volume = {8}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2017.00613}, pages = {15}, year = {2017}, abstract = {Age-related decline in executive functions and postural control due to degenerative processes in the central nervous system have been related to increased fall-risk in old age. Many studies have shown cognitive-postural dual-task interference in old adults, but research on the role of specific executive functions in this context has just begun. In this study, we addressed the question whether postural control is impaired depending on the coordination of concurrent response-selection processes related to the compatibility of input and output modality mappings as compared to impairments related to working-memory load in the comparison of cognitive dual and single tasks. Specifically, we measured total center of pressure (CoP) displacements in healthy female participants aged 19-30 and 66-84 years while they performed different versions of a spatial one-back working memory task during semi-tandem stance on an unstable surface (i.e., balance pad) while standing on a force plate. The specific working-memory tasks comprised: (i) modality compatible single tasks (i.e., visual-manual or auditory-vocal tasks), (ii) modality compatible dual tasks (i.e., visual-manual and auditory-vocal tasks), (iii) modality incompatible single tasks (i.e., visual-vocal or auditory-manual tasks), and (iv) modality incompatible dual tasks (i.e., visual-vocal and auditory-manual tasks). In addition, participants performed the same tasks while sitting. As expected from previous research, old adults showed generally impaired performance under high working-memory load (i.e., dual vs. single one-back task). In addition, modality compatibility affected one-back performance in dual-task but not in single-task conditions with strikingly pronounced impairments in old adults. Notably, the modality incompatible dual task also resulted in a selective increase in total CoP displacements compared to the modality compatible dual task in the old but not in the young participants. These results suggest that in addition to effects of working-memory load, processes related to simultaneously overcoming special linkages between input-and output modalities interfere with postural control in old but not in young female adults. Our preliminary data provide further evidence for the involvement of cognitive control processes in postural tasks.}, language = {en} } @article{NebeKroemerSchadetal.2017, author = {Nebe, Stephan and Kroemer, Nils B. and Schad, Daniel and Bernhardt, Nadine and Sebold, Miriam and Mueller, Dirk K. and Scholl, Lucie and Kuitunen-Paul, S{\"o}ren and Heinz, Andreas and Rapp, Michael A. and Huys, Quentin J. M. and Smolka, Michael N.}, title = {No association of goal-directed and habitual control with alcohol consumption in young adults}, series = {Addiction biology}, volume = {23}, journal = {Addiction biology}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1355-6215}, doi = {10.1111/adb.12490}, pages = {379 -- 393}, year = {2017}, abstract = {Alcohol dependence is a mental disorder that has been associated with an imbalance in behavioral control favoring model-free habitual over model-based goal-directed strategies. It is as yet unknown, however, whether such an imbalance reflects a predisposing vulnerability or results as a consequence of repeated and/or excessive alcohol exposure. We, therefore, examined the association of alcohol consumption with model-based goal-directed and model-free habitual control in 188 18-year-old social drinkers in a two-step sequential decision-making task while undergoing functional magnetic resonance imaging before prolonged alcohol misuse could have led to severe neurobiological adaptations. Behaviorally, participants showed a mixture of model-free and model-based decision-making as observed previously. Measures of impulsivity were positively related to alcohol consumption. In contrast, neither model-free nor model-based decision weights nor the trade-off between them were associated with alcohol consumption. There were also no significant associations between alcohol consumption and neural correlates of model-free or model-based decision quantities in either ventral striatum or ventromedial prefrontal cortex. Exploratory whole-brain functional magnetic resonance imaging analyses with a lenient threshold revealed early onset of drinking to be associated with an enhanced representation of model-free reward prediction errors in the posterior putamen. These results suggest that an imbalance between model-based goal-directed and model-free habitual control might rather not be a trait marker of alcohol intake per se.}, language = {en} } @article{HeinzelLorenzQuynhLamDuongetal.2017, author = {Heinzel, Stephan and Lorenz, Robert C. and Quynh-Lam Duong, and Rapp, Michael A. and Deserno, Lorenz}, title = {Prefrontal-parietal effective connectivity during working memory in older adults}, series = {Neurobiology of Aging}, volume = {57}, journal = {Neurobiology of Aging}, publisher = {Elsevier}, address = {New York}, issn = {0197-4580}, doi = {10.1016/j.neurobiolaging.2017.05.005}, pages = {18 -- 27}, year = {2017}, abstract = {Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory (WM)load-dependent manner. However, to date, underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood. The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection. Eighteen healthy younger (age: 20-32 years) and 32 older (60-75 years) participants performed an n-back task with 3 WM load levels during functional magnetic resonance imaging (fMRI). Behavioral and conventional fMRI results replicated age group by WM load interactions. Importantly, the analysis of effective connectivity derived from dynamic causal modeling, indicated an age-and performance-related reduction in WM load-dependent modulation of connectivity from dorsolateral prefrontal cortex to inferior parietal lobule. This finding provides evidence for the proposal that age-related WM decline manifests as deficient WM load-dependent modulation of neuronal top-down control and can integrate implications from theoretical models and previous studies of functional changes in the aging brain.}, language = {en} } @article{HeinzelRimpelStelzeletal.2017, author = {Heinzel, Stephan and Rimpel, J{\´e}r{\^o}me and Stelzel, Christine and Rapp, Michael A.}, title = {Transfer Effects to a Multimodal Dual-Task after Working Memory Training and Associated Neural Correlates in Older Adults}, series = {Frontiers in human neuroscience}, volume = {11}, journal = {Frontiers in human neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, doi = {10.3389/fnhum.2017.00085}, year = {2017}, abstract = {Working memory (WM) performance declines with age. However, several studies have shown that WM training may lead to performance increases not only in the trained task, but also in untrained cognitive transfer tasks. It has been suggested that transfer effects occur if training task and transfer task share specific processing components that are supposedly processed in the same brain areas. In the current study, we investigated whether single-task WM training and training-related alterations in neural activity might support performance in a dual-task setting, thus assessing transfer effects to higher-order control processes in the context of dual-task coordination. A sample of older adults (age 60-72) was assigned to either a training or control group. The training group participated in 12 sessions of an adaptive n-back training. At pre and post-measurement, a multimodal dual-task was performed in all participants to assess transfer effects. This task consisted of two simultaneous delayed match to sample WM tasks using two different stimulus modalities (visual and auditory) that were performed either in isolation (single-task) or in conjunction (dual-task). A subgroup also participated in functional magnetic resonance imaging (fMRI) during the performance of the n-back task before and after training. While no transfer to single-task performance was found, dual-task costs in both the visual modality (p < 0.05) and the auditory modality (p < 0.05) decreased at post-measurement in the training but not in the control group. In the fMRI subgroup of the training participants, neural activity changes in left dorsolateral prefrontal cortex (DLPFC) during one-back predicted post-training auditory dual-task costs, while neural activity changes in right DLPFC during three-back predicted visual dual-task costs. Results might indicate an improvement in central executive processing that could facilitate both WM and dual-task coordination.}, language = {en} } @article{JacobRappKostev2017, author = {Jacob, Louis and Rapp, Michael A. and Kostev, Karel}, title = {Long-term use of benzodiazepines in older patients in Germany}, series = {Therapeutic Advances in Psychopharmacology}, volume = {7}, journal = {Therapeutic Advances in Psychopharmacology}, number = {6/7}, publisher = {Sage Publ.}, address = {London}, issn = {2045-1253}, doi = {10.1177/2045125317696454}, pages = {191 -- 200}, year = {2017}, abstract = {Background: The purpose of this study was to analyze the prevalence of long-term benzodiazepine use in older adults treated in general and neuropsychiatric practices in Germany. Methods: This study included 32,182 patients over the age of 65 years who received benzodiazepine prescriptions for the first time between January 2010 and December 2014 in general and neuropsychiatric practices in Germany. Follow up lasted until July 2016. The main outcome measure was the proportion of patients treated with benzodiazepines for >6 months. Results: The proportion of patients with benzodiazepine therapy for >6 months increased with age (65-70 years: 12.3\%; 71-80 years: 15.5\%; 81-90 years: 23.7\%; >90 years: 31.6\%) but did not differ significantly between men (15.5\%) and women (17.1\%). The proportion of patients who received benzodiazepines for >6 months was higher among those with sleep disorders (21.1\%), depression (20.8\%) and dementia (32.1\%) than among those with anxiety (15.5\%). By contrast, this proportion was lower among people diagnosed with adjustment disorders (7.7\%) and back pain (3.8\%). Conclusion: Overall, long-term use of benzodiazepines is common in older people, particularly in patients over the age of 80 and in those diagnosed with dementia, sleep disorders, or depression.}, language = {en} } @article{BohlkenWeberSiebertetal.2017, author = {Bohlken, Jens and Weber, Simon A. and Siebert, Anke and Forstmeier, Simon and Kohlmann, Thomas and Rapp, Michael A.}, title = {Reminiscence therapy for depression in dementia}, series = {GeroPsych - The Journal of gerontopsychology and geriatric psychiatry}, volume = {30}, journal = {GeroPsych - The Journal of gerontopsychology and geriatric psychiatry}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {1662-9647}, doi = {10.1024/1662-9647/a000175}, pages = {145 -- 151}, year = {2017}, abstract = {We investigated the efficacy of reminiscence therapy (RT) on symptoms of depression in patients with mild to moderate dementia. Out of 227 patients with mild to moderate dementia from a specialized physician's office, 27 pairs (N = 54; mean age 79.04 ± 6.16 years) who had either received treatment as usual (TAU) or TAU combined with RT, were matched retrospectively according to age as well as cognitive and depressive symptom scores. After controlling for age and sex, symptoms of depression significantly decreased over time in the RT group compared to TAU (F1,52 = 4.36; p < .05). RT is a promising option for the treatment of depression in mild to moderate dementia. Larger randomized-controlled trials are needed.}, language = {en} } @misc{SchroenKoehliScheiffeleetal.2017, author = {Schr{\"o}n, Martin and K{\"o}hli, Markus and Scheiffele, Lena and Iwema, Joost and Bogena, Heye R. and Lv, Ling and Martini, Edoardo and Baroni, Gabriele and Rosolem, Rafael and Weimar, Jannis and Mai, Juliane and Cuntz, Matthias and Rebmann, Corinna and Oswald, Sascha and Dietrich, Peter and Schmidt, Ulrich and Zacharias, Steffen}, title = {Improving calibration and validation of cosmic-ray neutron sensors in the light of spatial sensitivity}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {636}, doi = {10.25932/publishup-41913}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-419134}, pages = {5009 -- 5030}, year = {2017}, abstract = {In the last few years the method of cosmic-ray neutron sensing (CRNS) has gained popularity among hydrologists, physicists, and land-surface modelers. The sensor provides continuous soil moisture data, averaged over several hectares and tens of decimeters in depth. However, the signal still may contain unidentified features of hydrological processes, and many calibration datasets are often required in order to find reliable relations between neutron intensity and water dynamics. Recent insights into environmental neutrons accurately described the spatial sensitivity of the sensor and thus allowed one to quantify the contribution of individual sample locations to the CRNS signal. Consequently, data points of calibration and validation datasets are suggested to be averaged using a more physically based weighting approach. In this work, a revised sensitivity function is used to calculate weighted averages of point data. The function is different from the simple exponential convention by the extraordinary sensitivity to the first few meters around the probe, and by dependencies on air pressure, air humidity, soil moisture, and vegetation. The approach is extensively tested at six distinct monitoring sites: two sites with multiple calibration datasets and four sites with continuous time series datasets. In all cases, the revised averaging method improved the performance of the CRNS products. The revised approach further helped to reveal hidden hydrological processes which otherwise remained unexplained in the data or were lost in the process of overcalibration. The presented weighting approach increases the overall accuracy of CRNS products and will have an impact on all their applications in agriculture, hydrology, and modeling.}, language = {en} } @phdthesis{deSouza2017, author = {de Souza, Laise Rosado}, title = {Metabolic signalling between organelles}, school = {Universit{\"a}t Potsdam}, pages = {112}, year = {2017}, language = {en} } @article{SchroenKoehliScheiffeleetal.2017, author = {Schr{\"o}n, Martin and K{\"o}hli, Markus and Scheiffele, Lena and Iwema, Joost and Bogena, Heye R. and Lv, Ling and Martini, Edoardo and Baroni, Gabriele and Rosolem, Rafael and Weimar, Jannis and Mai, Juliane and Cuntz, Matthias and Rebmann, Corinna and Oswald, Sascha and Dietrich, Peter and Schmidt, Ulrich and Zacharias, Steffen}, title = {Improving calibration and validation of cosmic-ray neutron sensors in the light of spatial sensitivity}, series = {Hydrology and earth system sciences : HESS}, volume = {21}, journal = {Hydrology and earth system sciences : HESS}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-21-5009-2017}, pages = {5009 -- 5030}, year = {2017}, abstract = {In the last few years the method of cosmic-ray neutron sensing (CRNS) has gained popularity among hydrologists, physicists, and land-surface modelers. The sensor provides continuous soil moisture data, averaged over several hectares and tens of decimeters in depth. However, the signal still may contain unidentified features of hydrological processes, and many calibration datasets are often required in order to find reliable relations between neutron intensity and water dynamics. Recent insights into environmental neutrons accurately described the spatial sensitivity of the sensor and thus allowed one to quantify the contribution of individual sample locations to the CRNS signal. Consequently, data points of calibration and validation datasets are suggested to be averaged using a more physically based weighting approach. In this work, a revised sensitivity function is used to calculate weighted averages of point data. The function is different from the simple exponential convention by the extraordinary sensitivity to the first few meters around the probe, and by dependencies on air pressure, air humidity, soil moisture, and vegetation. The approach is extensively tested at six distinct monitoring sites: two sites with multiple calibration datasets and four sites with continuous time series datasets. In all cases, the revised averaging method improved the performance of the CRNS products. The revised approach further helped to reveal hidden hydrological processes which otherwise remained unexplained in the data or were lost in the process of overcalibration. The presented weighting approach increases the overall accuracy of CRNS products and will have an impact on all their applications in agriculture, hydrology, and modeling.}, language = {en} } @article{SmirnovaFernieSpahnetal.2017, author = {Smirnova, Julia and Fernie, Alisdair R. and Spahn, Christian M. T. and Steup, Martin}, title = {Photometric assay of maltose and maltose-forming enzyme activity by using 4-alpha-glucanotransferase (DPE2) from higher plants}, series = {Analytical biochemistry : methods in the biological sciences}, volume = {532}, journal = {Analytical biochemistry : methods in the biological sciences}, publisher = {Elsevier}, address = {San Diego}, issn = {0003-2697}, doi = {10.1016/j.ab.2017.05.026}, pages = {72 -- 82}, year = {2017}, abstract = {Maltose frequently occurs as intermediate of the central carbon metabolism of prokaryotic and eukaryotic cells. Various mutants possess elevated maltose levels. Maltose exists as two anomers, (alpha- and beta-form) which are rapidly interconverted without requiring enzyme-mediated catalysis. As maltose is often abundant together with other oligoglucans, selective quantification is essential. In this communication, we present a photometric maltose assay using 4-alpha-glucanotransferase (AtDPE2) from Arabidopsis thaliana. Under in vitro conditions, AtDPE2 utilizes maltose as glucosyl donor and glycogen as acceptor releasing the other hexosyl unit as free glucose which is photometrically quantified following enzymatic phosphorylation and oxidation. Under the conditions used, DPE2 does not noticeably react with other di- or oligosaccharides. Selectivity compares favorably with that of maltase frequently used in maltose assays. Reducing end interconversion of the two maltose anomers is in rapid equilibrium and, therefore, the novel assay measures total maltose contents. Furthermore, an AtDPE2-based continuous photometric assay is presented which allows to quantify beta-amylase activity and was found to be superior to a conventional test. Finally, the AtDPE2-based maltose assay was used to quantify leaf maltose contents of both Arabidopsis wild type and AtDPE2-deficient plants throughout the light-dark cycle. These data are presented together with assimilatory starch levels. (C) 2017 Published by Elsevier Inc.}, language = {en} } @article{NiestaKayersSchwarz2017, author = {Niesta Kayers, Daniel and Schwarz, Sascha}, title = {Physical Appearance, Attractiveness and Relationships: Is the Display Versus Avoidance of the Color Red a Strategic Mating Signal?}, series = {Journal of Psychology \& Psychotherapy}, volume = {7}, journal = {Journal of Psychology \& Psychotherapy}, number = {2}, issn = {2161-0487}, doi = {10.4172/2161-0487.1000293}, pages = {4}, year = {2017}, abstract = {The present article focuses on the role of situational factors - such as the color red - and their influence on what humans notice in others. Humans form impressions of others instantly. These impressions are predominantly based on physical appearance, which is part due to a person's search for indicators of a potential partner's fitness. Attractive individuals are associated with all sorts of positive qualities, whereas their less attractive counterparts are less favorably depicted. This perception process of physical attractiveness is associated with health in male and female faces, and from an evolutionary point of view, serves the survival and the reproductive success of the perceiver. The meaning of the color red for approach and avoidance behavior is demonstrated in a recent study, which shows that women's use (or avoidance) of red clothing, accessories, and make-up may serve as a subtle and strategic indicator of (missing) sexual interest.}, language = {en} } @phdthesis{Richter2017, author = {Richter, Ronny Rudi}, title = {Strafvereitelung wegen Nichtanzeige von Straftaten nach Pr{\"u}fungen durch die Stellen zur Bek{\"a}mpfung von Fehlverhalten im Gesundheitswesen}, series = {Schriftenreihe zum deutschen, europ{\"a}ischen und internationalen Wirtschaftsstrafrecht ; Band 32}, journal = {Schriftenreihe zum deutschen, europ{\"a}ischen und internationalen Wirtschaftsstrafrecht ; Band 32}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-4080-2}, school = {Universit{\"a}t Potsdam}, pages = {321}, year = {2017}, abstract = {Nicht jeder kann sich wegen Strafvereitelung durch Nichtanzeige einer Straftat bei der Staatsanwaltschaft strafbar machen. Doch wie ist es, wenn eine Anzeige unterbleibt, nachdem die Stellen zur Bek{\"a}mpfung von Fehlverhalten im Gesundheitswesen einen Verdacht festgestellt haben? Die Arbeit gibt, nach eingehenden Untersuchungen, die Antwort. Sie zeigt, wer sich strafbar machen kann, erl{\"a}utert das Aufgabenfeld der Stellen, die Voraussetzungen der Anzeigepflicht und die einzelnen strafrechtlichen Problempunkte. Zu entscheidenden Streitfragen bezieht die Untersuchung Stellung. Beantwortet werden diverse Fragen, u.a. ob die Vorstandsmitglieder der Kassen{\"a}rztlichen Vereinigungen, der Orts-, Betriebs-, Innungs- und Ersatzkassen, die Gesch{\"a}ftsf{\"u}hrer der Deutschen Rentenversicherung Knappschaft-Bahn-See und der Sozialversicherung f{\"u}r Landwirtschaft, Forsten und Gartenbau sowie die Mitarbeiter der jeweiligen Stellen, Garanten zum Schutz der Strafrechtspflege sind.}, language = {de} } @article{AbdallaAbramowskiAharonianetal.2017, author = {Abdalla, H. and Abramowski, A. and Aharonian, Felix A. and Benkhali, F. Ait and Akhperjanian, A. G. and Andersson, T. and Anguener, E. O. and Arrieta, M. and Aubert, P. and Backes, M. and Balzer, A. and Barnard, M. and Becherini, Y. and Tjus, J. Becker and Berge, D. and Bernhard, S. and Bernlorhr, K. and Blackwell, R. and Bottcher, M. and Boisson, C. and Bolmont, J. and Bordas, Pol and Bregeon, J. and Brun, F. and Brun, P. and Bryan, M. and Bulik, T. and Capasso, M. and Carr, J. and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chalme-Calvet, R. and Chaves, R. C. G. and Chen, A. and Chevalier, J. and Chretien, M. and Colafrancesco, S. and Cologna, G. and Condon, B. and Conrad, J. and Cui, Y. and Davids, I. D. and Decock, J. and Degrange, B. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Domainko, W. and Donath, A. and Dubus, G. and Dutson, K. and Dyks, J. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, S. and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Foerster, A. and Funk, S. and Fuessling, M. and Gabici, S. and Gajdus, M. and Gallant, Y. A. and Garrigoux, T. and Giavitto, G. and Giebels, B. and Glicenstein, J. F. and Gottschall, D. and Goyal, A. and Grondin, M. -H. and Hadasch, D. and Hahn, J. and Haupt, M. and Hawkes, J. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hervet, O. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holler, M. and Horns, D. and Ivascenko, A. and Jacholkowska, A. and Jamrozy, M. and Janiak, M. and Jankowsky, D. and Jankowsky, F. and Jingo, M. and Jogler, T. and Jouvin, L. and Jung-Richardt, I. and Kastendieck, M. A. and Katarzynski, K. and Katz, U. and Kerszberg, D. and Khelifi, B. and Er, M. Kie Ff and King, J. and Klepser, S. and Klochkov, D. and Kluzniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, M. and Krayzel, F. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, J. and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, E. and Lohse, T. and Lorentz, M. and Liu, R. and Lopez-Coto, R. and Lypova, I. and Marandon, V. and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, M. and Meintjes, P. J. and Meyer, M. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Mora, K. and Moulin, Emmanuel and Murach, T. and de Naurois, M. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Oettl, S. and Ohm, S. and Ostrowski, M. and Oya, I. and Padovani, M. and Panter, M. and Parsons, R. D. and Pekeur, N. W. and Pelletier, G. and Perennes, C. and Petrucci, P. -O. and Peyaud, B. and Piel, Q. and Pita, S. and Poon, H. and Prokhorov, D. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Reimer, A. and Reimer, O. and Renaud, M. and de los Reyes, R. and Rieger, F. and Romoli, C. and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Salek, D. and Sanchez, D. A. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schwanke, U. and Schwemmer, S. and Settimo, M. and Seyffert, A. S. and Shafi, N. and Shilon, I. and Simoni, R. and Sol, H. and Spanier, F. and Spengler, G. and Spies, F. and Ert, Ff and Stawarz, L. and Steenkamp, R. and Stegmann, Christian Michael and Stinzing, F. and Stycz, K. and Sushch, I. and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tibaldo, L. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, R. and Zabalza, V. and Zaborov, D. and Zacharias, M. and Zdziarski, A. A. and Zech, Alraune and Zefi, F. and Ziegler, A. and Zywucka, N.}, title = {Characterizing the gamma-ray long-term variability of PKS2155 304 with HESS and Fermi-LAT}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {598}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201629419}, pages = {11}, year = {2017}, abstract = {Studying the temporal variability of BL Lac objects at the highest energies provides unique insights into the extreme physical processes occurring in relativistic jets and in the vicinity of super-massive black holes. To this end, the long-term variability of the BL Lac object PKS 2155 304 is analyzed in the high (HE, 100MeV < E < 300 GeV) and very high energy (VHE, E > 200 GeV) gamma-ray domain. Over the course of similar to 9 yr of H. E. S. S. observations the VHE light curve in the quiescent state is consistent with a log-normal behavior. The VHE variability in this state is well described by flicker noise (power-spectral-density index beta(VHE) = 1 .10(+ 0 : 10) (0 : 13)) on timescales larger than one day. An analysis of similar to 5.5 yr of HE Fermi-LAT data gives consistent results (beta(HE) = 1 : 20(+ 0 : 21) (0 : 23), on timescales larger than 10 days) compatible with the VHE findings. The HE and VHE power spectral densities show a scale invariance across the probed time ranges. A direct linear correlation between the VHE and HE fluxes could neither be excluded nor firmly established. These long-term-variability properties are discussed and compared to the red noise behavior (beta similar to 2) seen on shorter timescales during VHE-flaring states. The difference in power spectral noise behavior at VHE energies during quiescent and flaring states provides evidence that these states are influenced by different physical processes, while the compatibility of the HE and VHE long-term results is suggestive of a common physical link as it might be introduced by an underlying jet-disk connection.}, language = {en} } @article{AminovDingMamadjonovetal.2017, author = {Aminov, Jovid and Ding, Lin and Mamadjonov, Yunus and Dupont-Nivet, Guillaume and Aminov, Jamshed and Zhang, Li-Yun and Yoqubov, Shokirjon and Aminov, Javhar and Abdulov, Sherzod}, title = {Pamir Plateau formation and crustal thickening before the India-Asia collision inferred from dating and petrology of the 110-92 Ma Southern Pamir volcanic sequence}, series = {Gondwana research : international geoscience journal ; official journal of the International Association for Gondwana Research}, volume = {51}, journal = {Gondwana research : international geoscience journal ; official journal of the International Association for Gondwana Research}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1342-937X}, doi = {10.1016/j.gr.2017.08.003}, pages = {310 -- 326}, year = {2017}, abstract = {The formation of the Pamir is a key component of the India-Asia collision with major implications for lithospheric processes, plateau formation, land-sea configurations and associated climate changes. Although the formation of the Pamir is traditionally linked to Cenozoic processes associated with the India-Asia collision, the contribution of the Mesozoic tectonic evolution remains poorly understood. The Pamir was formed by the suturing of Gondwanan terranes to the south margin of Eurasia, however, the timing and tectonic mechanisms associated with this Mesozoic accretion remain poorly constrained. These processes are recorded by several igneous belts within these terranes, which are not well studied. Within the Southern Pamir, the Albian-Turonian volcanic rocks and comagmatic plutons of the Kyzylrabat Igneous Complex (KIC) provide an important and still unconstrained record of the Pamir evolution. Here we provide the age, origin and the geodynamic setting of the KIC volcanics by studying their petrology, zircon U-Pb geochronology, geochemistry and isotope composition.17 samples from the KIC volcanics yield U-Pb ages spanning from 92 to 110 Ma. The volcanics are intermediate to acidic in composition (SiO2 = 56-69 wt\%) and exhibit high-K calc-alkaline and shoshonitic affinity (K2O/Na2O = 12.2 wt\%). They show enrichment in LILE and LREE and depletion in HFSE and HREE with negative Ta, Ti and Nb anomalies, suggesting an arc-related tectonic setting for their formation. Low sNd(t) values (from 9.1 to 4.7), relatively high Sr-87/Sr-86(i) ratios (0.7069-0.7096) and broad range of zircon stif values (from 22.6 to 1.5) suggest a mixture of different magma sources. These features suggest that volcanics were derived by crustal under- or intraplating of an enriched subduction-related mantle shoshonitic magmas, by heating and partial melting of the lower crust, and by mixing of both magma components. Our results further imply that the KIC volcanics represent a shoshonitic suite typical of an evolution from active continental arc to post-collisional setting with a steepening of the Benioff zone and thickening of the crust toward the back-arc. This setting is best explained by the subduction- collision transition along the Shyok suture due to accretion of the Kohistan island arc to the Karakoram. This suggests that a significant part of the crustal shortening and thickening accommodated in the Pamir occurred in the Mesozoic before the India-Asia collision with implications for regional tectonic models. This further suggests the Pamir was already a major topographic feature with potentially important paleoclimate forcing such as the monsoonal circulation. (C) 2017 International Association for Gondwana Research. Published by Elsevier B.V. All rights reserved.}, language = {en} } @article{SeboldNebeGarbusowetal.2017, author = {Sebold, Miriam and Nebe, Stephan and Garbusow, Maria and Guggenmos, Matthias and Schad, Daniel and Beck, Anne and Kuitunen-Paul, S{\"o}ren and Sommer, Christian and Frank, Robin and Neu, Peter and Zimmermann, Ulrich S. and Rapp, Michael A. and Smolka, Michael N. and Huys, Quentin J. M. and Schlagenhauf, Florian and Heinz, Andreas}, title = {When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence}, series = {Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry}, volume = {82}, journal = {Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry}, publisher = {Elsevier}, address = {New York}, issn = {0006-3223}, doi = {10.1016/j.biopsych.2017.04.019}, pages = {847 -- 856}, year = {2017}, abstract = {BACKGROUND: Addiction is supposedly characterized by a shift from goal-directed to habitual decision making, thus facilitating automatic drug intake. The two-step task allows distinguishing between these mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-free control. In addicted patients, decision making may also strongly depend upon drug-associated expectations. Therefore, we investigated model-based versus model-free decision making and its neural correlates as well as alcohol expectancies in alcohol-dependent patients and healthy controls and assessed treatment outcome in patients. METHODS: Ninety detoxified, medication-free, alcohol-dependent patients and 96 age-and gender-matched control subjects underwent functional magnetic resonance imaging during the two-step task. Alcohol expectancies were measured with the Alcohol Expectancy Questionnaire. Over a follow-up period of 48 weeks, 37 patients remained abstinent and 53 patients relapsed as indicated by the Alcohol Timeline Followback method. RESULTS: Patients who relapsed displayed reduced medial prefrontal cortex activation during model-based decision making. Furthermore, high alcohol expectancies were associated with low model-based control in relapsers, while the opposite was observed in abstainers and healthy control subjects. However, reduced model-based control per se was not associated with subsequent relapse. CONCLUSIONS: These findings suggest that poor treatment outcome in alcohol dependence does not simply result from a shift from model-based to model-free control but is instead dependent on the interaction between high drug expectancies and low model-based decision making. Reduced model-based medial prefrontal cortex signatures in those who relapse point to a neural correlate of relapse risk. These observations suggest that therapeutic interventions should target subjective alcohol expectancies.}, language = {en} } @misc{ZechRappHeinzeletal.2017, author = {Zech, Philipp A. and Rapp, Michael A. and Heinzel, Stephan and Wolfarth, Bernd and Lawrence, Jimmy B. and Heissel, Andreas}, title = {Does Exercise Help People Living with HIV Improve Their Quality of Life? A meta-analysis.}, series = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, volume = {49}, journal = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0195-9131}, doi = {10.1249/01.mss.0000518177.22369.2f}, pages = {470 -- 470}, year = {2017}, language = {en} } @article{MellJacobFuhretal.2017, author = {Mell, Thomas and Jacob, Louis and Fuhr, Ida and Dick, Sandra and Rapp, Michael A. and Kostev, Karel}, title = {Patterns of benzodiazepine prescribing by neuropsychiatrists and general practitioners for elderly patients in Germany in 2014}, series = {International journal of clinical pharmacology and therapeutics}, volume = {55}, journal = {International journal of clinical pharmacology and therapeutics}, publisher = {Dustri-Verlag Dr. Karl Feistle}, address = {Deisenhofen-M{\"u}nchen}, issn = {0946-1965}, doi = {10.5414/CP202904}, pages = {466 -- 471}, year = {2017}, abstract = {Background: The patterns of benzodiazepine prescriptions in older adults are of general and scientific interest as they are not yet well understood. The aim of this study was to compare the prescription patterns of benzodiazepines in elderly people in Germany to determine the share or proportion treated by general practitioners (GP) and neuropsychiatrists (NP). Methods: This study included 31,268 and 6,603 patients between the ages of 65 and 100 with at least one benzodiazepine prescription in 2014 from GP and NP, respectively. Demographic data included age, gender, and type of health insurance coverage. The share of elderly people with benzodiazepine prescriptions was estimated in different age and disease groups for both GP and NP patients. The share of the six most commonly prescribed drugs was also calculated for each type of practice. Results: The share of people taking benzodiazepines prescribed by GP increased from 3.2\% in patients aged between 65 and 69 years to 8.6\% in patients aged between 90 and 100 years, whereas this share increased from 5.4\% to 7.1\% in those seen by NP. Benzodiazepines were frequently used by patients suffering from sleep disorders (GP: 33.9\%; NP: 5.5\%), depression (GP: 17.9\%; NP: 29.8\%), and anxiety disorders (GP: 14.5\%; NP: 22.8\%). Lorazepam (30.3\%), oxazepam (24.7\%), and bromazepam (24.3\%) were the three most commonly prescribed drugs for GP patients. In contrast, lorazepam (60.4\%), diazepam (14.8\%), and oxazepam (11.2\%) were those more frequently prescribed to NP patients. Conclusion: Prescription patterns of benzodiazepine in the elderly varied widely between GP and NP.}, language = {en} } @article{KocReinhardtReppertetal.2017, author = {Koc, A. and Reinhardt, M. and Reppert, Alexander von and R{\"o}ssle, Matthias and Leitenberger, Wolfram and Gleich, M. and Weinelt, M. and Zamponi, Flavio and Bargheer, Matias}, title = {Grueneisen-approach for the experimental determination of transient spin and phonon energies from ultrafast x-ray diffraction data: gadolinium}, series = {Journal of physics : Condensed matter}, volume = {29}, journal = {Journal of physics : Condensed matter}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0953-8984}, doi = {10.1088/1361-648X/aa7187}, pages = {5884 -- 5891}, year = {2017}, abstract = {We study gadolinium thin films as a model system for ferromagnets with negative thermal expansion. Ultrashort laser pulses heat up the electronic subsystem and we follow the transient strain via ultrafast x-ray diffraction. In terms of a simple Grueneisen approach, the strain is decomposed into two contributions proportional to the thermal energy of spin and phonon subsystems. Our analysis reveals that upon femtosecond laser excitation, phonons and spins can be driven out of thermal equilibrium for several nanoseconds.}, language = {en} } @article{BaltaBeylergilBeckDesernoetal.2017, author = {Balta Beylergil, Sinem and Beck, Anne and Deserno, Lorenz and Lorenz, Robert C. and Rapp, Michael A. and Schlagenhauf, Florian and Heinz, Andreas and Obermayer, Klaus}, title = {Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence}, series = {NeuroImage: Clinical : a journal of diseases affecting the nervous system}, volume = {15}, journal = {NeuroImage: Clinical : a journal of diseases affecting the nervous system}, publisher = {Elsevier}, address = {Oxford}, issn = {2213-1582}, doi = {10.1016/j.nicl.2017.04.010}, pages = {80 -- 94}, year = {2017}, abstract = {Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the "double-update" model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.}, language = {en} } @misc{GruebnerRappAdlietal.2017, author = {Gruebner, Oliver and Rapp, Michael A. and Adli, Mazda and Kluge, Ulrike and Galea, Sandro and Heinz, Andreas}, title = {Cities and Mental Health}, series = {Deutsches {\"A}rzteblatt international : a weekly online journal of clinical medicine and public health}, volume = {114}, journal = {Deutsches {\"A}rzteblatt international : a weekly online journal of clinical medicine and public health}, number = {8}, publisher = {Dt. {\"A}rzte-Verl.}, address = {Cologne}, issn = {1866-0452}, doi = {10.3238/arztebl.2017.0121}, pages = {121 -- 127}, year = {2017}, abstract = {Background: More than half of the global population currently lives in cities, with an increasing trend for further urbanization. Living in cities is associated with increased population density, traffic noise and pollution, but also with better access to health care and other commodities. Methods: This review is based on a selective literature search, providing an overview of the risk factors for mental illness in urban centers. Results: Studies have shown that the risk for serious mental illness is generally higher in cities compared to rural areas. Epidemiological studies have associated growing up and living in cities with a considerably higher risk for schizophrenia. However, correlation is not causation and living in poverty can both contribute to and result from impairments associated with poor mental health. Social isolation and discrimination as well as poverty in the neighborhood contribute to the mental health burden while little is known about specific inter actions between such factors and the built environment. Conclusion: Further insights on the interaction between spatial heterogeneity of neighborhood resources and socio-ecological factors is warranted and requires interdisciplinary research.}, language = {en} } @article{ProborukmiUrbanMischkeetal.2017, author = {Proborukmi, Maria Sekar and Urban, Brigitte and Mischke, Steffen and Mienis, Henk K. and Melamed, Yoel and Dupont-Nivet, Guillaume and Jourdan, Fred and Goren-Inbar, Naama}, title = {Evidence for climatic changes around the Matuyama-Brunhes Boundary (MBB) inferred from a multi-proxy palaeoenvironmental study of the GBY\#2 core, Jordan River Valley, Israel}, series = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, volume = {489}, journal = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0031-0182}, doi = {10.1016/j.palaeo.2017.10.007}, pages = {166 -- 185}, year = {2017}, abstract = {The Acheulian site of Gesher Benot Ya'aqov (GBY) in the Upper Jordan Valley revealed important data on environment and material culture, as well as evidence for hominin behavioural and cognitive patterns documented at the margins of the Hula Palaeo-lake. A 50 m long core (GBY\#2) drilled at the archaeological site has provided a long Pleistocene geological, environmental and climatological record, which expands the existing knowledge of hominin-habitat relationships. Bracketed by two basalt flows dated by 40Ar/39Ar and based on the identification of the Matuyama-Brunhes Boundary (MBB) and correlation with the GBY excavation site, the sedimentary sequence provides the climatic history around the MBB. Multi-proxy data including pollen and non-pollen palynomorphs, macro-botanical remains, molluscs and ostracods provide evidence for lake and lake-margin environments during Marine Isotope Stages (MIS) 20 and 19. Semi-moist conditions were followed by a pronounced dry phase during MIS 20, and warm and moist conditions with Quercus-Pistacia woodlands prevailed during MIS 19. In contrast to the reconstructed climate change from relatively dry to moister conditions, the depositional environment developed from an open-water lake during MIS 20 to a lake margin environment in MIS 19. Generally shallower conditions at the core site in MIS 19 resulted from the progradation of the lake shore due to the filling of the basin. Micro-charcoal analysis suggests a likelihood of human-induced fire in some parts of the core, which can be correlated with artefact-containing layers of the GBY excavation site. The Hula Palaeo-lake region provided an ideal niche for hominins and other vertebrates during global glacial-interglacial climate fluctuations at the end of the Early Pleistocene.}, language = {en} } @article{SierLangereisDupontNivetetal.2017, author = {Sier, Mark J. and Langereis, Cor G. and Dupont-Nivet, Guillaume and Feibel, Craig S. and Joordens, Josephine C. A. and van der Lubbe, Jeroen Fiji. and Beck, Catherine C. and Olago, Daniel and Cohen, Andrew}, title = {The top of the Olduvai Subchron in a high-resolution magnetostratigraphy from the West Turkana core WTK13, hominin sites and Paleolakes Drilling Project (HSPDP)}, series = {Quaternary geochronology : the international research and review journal on advances in quaternary dating techniques}, volume = {42}, journal = {Quaternary geochronology : the international research and review journal on advances in quaternary dating techniques}, publisher = {Elsevier}, address = {Oxford}, organization = {WTK Science Team Members}, issn = {1871-1014}, doi = {10.1016/j.quageo.2017.08.004}, pages = {117 -- 129}, year = {2017}, abstract = {One of the major challenges in understanding the evolution of our own species is identifying the role climate change has played in the evolution of hominin species. To clarify the influence of climate, we need long and continuous high-resolution paleoclimate records, preferably obtained from hominin-bearing sediments, that are well-dated by tephro- and magnetostratigraphy and other methods. This is hindered, however, by the fact that fossil-bearing outcrop sediments are often discontinuous, and subject to weathering, which may lead to oxidation and remagnetization. To obtain fresh, unweathered sediments, the Hominin Sites and Paleolakes Drilling Project (HSPDP) collected a \&\#8764;216-meter core (WTK13) in 2013 from Early Pleistocene Paleolake Lorenyang deposits in the western Turkana Basin (Kenya). Here, we present the magnetostratigraphy of the WTK13 core, providing a first age model for upcoming HSPDP paleoclimate and paleoenvrionmental studies on the core sediments. Rock magnetic analyses reveal the presence of iron sulfides carrying the remanent magnetizations. To recover polarity orientation from the near-equatorial WTK13 core drilled at 5°N, we developed and successfully applied two independent drill-core reorientation methods taking advantage of (1) the sedimentary fabric as expressed in the Anisotropy of Magnetic Susceptibility (AMS) and (2) the occurrence of a viscous component oriented in the present day field. The reoriented directions reveal a normal to reversed polarity reversal identified as the top of the Olduvai Subchron. From this excellent record, we find no evidence for the 'Vrica Subchron' previously reported in the area. We suggest that outcrop-based interpretations supporting the presence of the Vrica Subchron have been affected by the oxidation of iron sulfides initially present in the sediments -as evident in the core record- and by subsequent remagnetization. We discuss the implications of the observed geomagnetic record for human evolution studies.}, language = {en} } @article{BallatoCifelliHeidarzadehetal.2017, author = {Ballato, Paolo and Cifelli, Francesca and Heidarzadeh, Ghasem and Ghassemi, Mohammad R. and Wickert, Andrew D. and Hassanzadeh, Jamshid and Dupont-Nivet, Guillaume and Balling, Philipp and Sudo, Masafumi and Zeilinger, Gerold and Schmitt, Axel K. and Mattei, Massimo and Strecker, Manfred}, title = {Tectono-sedimentary evolution of the northern Iranian Plateau: insights from middle-late Miocene foreland-basin deposits}, series = {Basin research}, volume = {29}, journal = {Basin research}, publisher = {Wiley}, address = {Hoboken}, issn = {0950-091X}, doi = {10.1111/bre.12180}, pages = {417 -- 446}, year = {2017}, abstract = {Sedimentary basins in the interior of orogenic plateaus can provide unique insights into the early history of plateau evolution and related geodynamic processes. The northern sectors of the Iranian Plateau of the Arabia-Eurasia collision zone offer the unique possibility to study middle-late Miocene terrestrial clastic and volcaniclastic sediments that allow assessing the nascent stages of collisional plateau formation. In particular, these sedimentary archives allow investigating several debated and poorly understood issues associated with the long-term evolution of the Iranian Plateau, including the regional spatio-temporal characteristics of sedimentation and deformation and the mechanisms of plateau growth. We document that middle-late Miocene crustal shortening and thickening processes led to the growth of a basement-cored range (Takab Range Complex) in the interior of the plateau. This triggered the development of a foreland-basin (Great Pari Basin) to the east between 16.5 and 10.7Ma. By 10.7Ma, a fast progradation of conglomerates over the foreland strata occurred, most likely during a decrease in flexural subsidence triggered by rock uplift along an intraforeland basement-cored range (Mahneshan Range Complex). This was in turn followed by the final incorporation of the foreland deposits into the orogenic system and ensuing compartmentalization of the formerly contiguous foreland into several intermontane basins. Overall, our data suggest that shortening and thickening processes led to the outward and vertical growth of the northern sectors of the Iranian Plateau starting from the middle Miocene. This implies that mantle-flow processes may have had a limited contribution toward building the Iranian Plateau in NW Iran.}, language = {en} } @article{LichtCosterOcakogluetal.2017, author = {Licht, Alexis and Coster, P. and Ocakoglu, F. and Campbell, C. and Metais, G. and Mulch, Andreas and Taylor, M. and Kappelman, John and Beard, K. Christopher}, title = {Tectono-stratigraphy of the Orhaniye Basin, Turkey: Implications for collision chronology and Paleogene biogeography of central Anatolia}, series = {Journal of Asian earth sciences}, volume = {143}, journal = {Journal of Asian earth sciences}, publisher = {Elsevier}, address = {Oxford}, issn = {1367-9120}, doi = {10.1016/j.jseaes.2017.03.033}, pages = {45 -- 58}, year = {2017}, abstract = {Located along the Izmir-Ankara-Erzincan Suture (IAES), the Maastrichtian - Paleogene Orhaniye Basin has yielded a highly enigmatic-yet poorly dated- Paleogene mammal fauna, the endemic character of which has suggested high faunal provincialism associated with paleogeographic isolation of the Anatolian landmass during the early Cenozoic. Despite its biogeographic significance, the tectono-stratigraphic history of the Orhaniye Basin has been poorly documented; Here, we combine sedimentary, magnetostratigraphic, and geochronological data to infer the chronology and depositional history of the Orhaniye Basin. We then assess how our new data and interpretations for the Orhaniye Basin impact (1) the timing and mechanisms of seaway closure along the IAES and (2) the biogeographic evolution of Anatolia. Our results show that the Orhaniye Basin initially developed as a forearc basin during the Maastrichtian, before shifting to a retroarc foreland basin setting sometime between the early Paleocene and 44 Ma. This chronology supports a two-step scenario for the assemblage of the central Anatolian landmass, with incipient collision during the Paleocene - Early Eocene and final seaway retreat along the IAES during the earliest Late Eocene after the last marine incursion into the foreland basin. Our dating for the Orhaniye mammal fauna (44-43 Ma) indicates the persistence of faunal endemism in northern Anatolia until at least the late Lutetian despite the advanced stage of IAES closure. The tectonic evolution of dispersal corridors linking northern Anatolia with adjacent parts of Eurasia was not directly associated with IAES closure and consecutive uplifts, but rather with the build-up of continental bridges on the margins of Anatolia, in the Alpine and Tibetan-Himalayan orogens.}, language = {en} } @article{GerlachGlueck2017, author = {Gerlach, Moritz Reinhardt and Gl{\"u}ck, Jochen}, title = {On a convergence theorem for semigroups of positive integral operators}, series = {Comptes Rendus Mathematique}, volume = {355}, journal = {Comptes Rendus Mathematique}, publisher = {Elsevier}, address = {Paris}, issn = {1631-073X}, doi = {10.1016/j.crma.2017.07.017}, pages = {973 -- 976}, year = {2017}, abstract = {We give a new and very short proof of a theorem of Greiner asserting that a positive and contractive -semigroup on an -space is strongly convergent in case it has a strictly positive fixed point and contains an integral operator. Our proof is a streamlined version of a much more general approach to the asymptotic theory of positive semigroups developed recently by the authors. Under the assumptions of Greiner's theorem, this approach becomes particularly elegant and simple. We also give an outlook on several generalisations of this result.}, language = {en} } @article{WangBekeschusHandorfetal.2017, author = {Wang, Yongbo and Bekeschus, Benjamin and Handorf, D{\"o}rthe and Liu, Xingqi and Dallmeyer, Anne and Herzschuh, Ulrike}, title = {Coherent tropical-subtropical Holocene see-saw moisture patterns in the Eastern Hemisphere monsoon systems}, series = {Quaternary science reviews : the international multidisciplinary research and review journal}, volume = {169}, journal = {Quaternary science reviews : the international multidisciplinary research and review journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0277-3791}, doi = {10.1016/j.quascirev.2017.06.006}, pages = {231 -- 242}, year = {2017}, abstract = {The concept of a Global Monsoon (GM) has been proposed based on modern precipitation observations, but its application over a wide range of temporal scales is still under debate. Here, we present a synthesis of 268 continental paleo-moisture records collected from monsoonal systems in the Eastern Hemisphere, including the East Asian Monsoon (EAsM), the Indian Monsoon (IM), the East African Monsoon (EAfM), and the Australian Monsoon (AuM) covering the last 18,000 years. The overall pattern of late Glacial to Holocene moisture change is consistent with those inferred from ice cores and marine records. With respect to the last 10,000 years (10 ka), i.e. a period that has high spatial coverage, a Fuzzy c-Means clustering analysis of the moisture index records together with "Xie-Beni" index reveals four clusters of our data set. The paleoclimatic meaning of each cluster is interpreted considering the temporal evolution and spatial distribution patterns. The major trend in the tropical AuM, EAfM, and IM regions is a gradual decrease in moisture conditions since the early Holocene. Moisture changes in the EAsM regions show maximum index values between 8 and 6 ka. However, records located in nearby subtropical areas, i.e. in regions not influenced by the intertropical convergence zone, show an opposite trend compared to the tropical monsoon regions (AuM, EAfM and IM), i.e. a gradual increase. Analyses of modern meteorological data reveal the same spatial patterns as in the paleoclimate records such that, in times of overall monsoon strengthening, lower precipitation rates are observed in the nearby subtropical areas. We explain this pattern as the effect of a strong monsoon circulation suppressing air uplift in nearby subtropical areas, and hence hindering precipitation. By analogy to the modern system, this would mean that during the early Holocene strong monsoon period, the intensified ascending airflows within the monsoon domains led to relatively weaker ascending or even descending airflows in the adjacent subtropical regions, resulting in a precipitation deficit compared to the late Holocene. Our conceptual model therefore integrates regionally contrasting moisture changes into the Global Monsoon hypothesis. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} } @article{ReilImholtRosenfeldetal.2017, author = {Reil, Daniela and Imholt, Christian and Rosenfeld, Ulrike and Drewes, Stephan and Fischer, S. and Heuser, Emil and Petraityte-Burneikiene, Rasa and Ulrich, R. G. and Jacob, J.}, title = {Validation of the Puumala virus rapid field test for bank voles in Germany}, series = {Epidemiology and infection}, volume = {145}, journal = {Epidemiology and infection}, number = {3}, publisher = {Cambridge Univ. Press}, address = {New York}, issn = {0950-2688}, doi = {10.1017/S0950268816002557}, pages = {434 -- 439}, year = {2017}, abstract = {Puumala virus (PUUV) causes many human infections in large parts of Europe and can lead to mild to moderate disease. The bank vole (Myodes glareolus) is the only reservoir of PUUV in Central Europe. A commercial PUUV rapid field test for rodents was validated for bank-vole blood samples collected in two PUUV-endemic regions in Germany (North Rhine-Westphalia and Baden-Wurttemberg). A comparison of the results of the rapid field test and standard ELISAs indicated a test efficacy of 93-95\%, largely independent of the origin of the antigens used in the ELISA. In ELISAs, reactivity for the German PUUV strain was higher compared to the Swedish strain but not compared to the Finnish strain, which was used for the rapid field test. In conclusion, the use of the rapid field test can facilitate short-term estimation of PUUV seroprevalence in bank-vole populations in Germany and can aid in assessing human PUUV infection risk.}, language = {en} } @article{Philipowski2017, author = {Philipowski, Katharina}, title = {Exemplarik und Erfahrung in allegorischen Ich-Erz{\"a}hlungen (am Beispiel von Konrads von W{\"u}rzburg 'Klage der Kunst')}, series = {Beitr{\"a}ge zur Geschichte der deutschen Sprache und Literatur (PBB)}, volume = {139}, journal = {Beitr{\"a}ge zur Geschichte der deutschen Sprache und Literatur (PBB)}, number = {3}, publisher = {de Gruyter}, address = {Berlin}, issn = {0005-8076}, doi = {10.1515/bgsl-2017-0029}, pages = {377 -- 410}, year = {2017}, abstract = {Most of the longer worldly fictional Middle High German first-person narrations are allegorical. The article discusses the reasons for this interdependence between allegory and the first-person narrative form, which is observable not only in Middle High German literature, but also in texts belonging to other European vernacular literatures of the time. In my article I develop two main thesis: The first is that the use of allegoric forms marks on the one hand a highbrow literary level and serves as a stylistic ornament of texts, which tend to present themselves mainly as author-speech. This is also the reason why in these texts the ›I‹ is often not only a narrating ›I‹, but also takes over the role of an author on the narrative level of the histoire. The other reason for this interdependence is that among all kinds of narrators, only the first-person narrator is able to cross the border between the extradiegetic and the diegetic world, in which personifications like Frau Minne, Frau Triuwe, or Frau {\^A}ventiure have the knowledge about Minne, Triuwe, and {\^A}ventiure and wait for the first-person narrator to approach and to be taught. Only he can experience the encounter with the personifications and their instruction himself and only he can pass this knowledge to the recipients as an experience he made himself.}, language = {de} } @book{OPUS4-44395, title = {Von sich selbst erz{\"a}hlen}, series = {Studien zur historischen Poetik ; 26}, journal = {Studien zur historischen Poetik ; 26}, editor = {Glauch, Sonja and Philipowski, Katharina}, publisher = {Universit{\"a}tsverlag Winter}, address = {Heidelberg}, isbn = {978-3-8253-6862-3}, publisher = {Universit{\"a}t Potsdam}, pages = {XVIII, 524}, year = {2017}, abstract = {Innerhalb der Medi{\"a}vistik ist das volkssprachige Erz{\"a}hlen in der ersten Person bisher weder erz{\"a}hltheoretisch noch in seinem Verh{\"a}ltnis zu Gattungstypen hinreichend aufgearbeitet. Dabei spielt diese Erz{\"a}hlhaltung literarhistorisch eine außerordentlich bedeutsame Rolle sowohl f{\"u}r die Entwicklung der Gattung des Romans in der Fr{\"u}hen Neuzeit als auch f{\"u}r die Entwicklung der Idee des fiktionalen Erz{\"a}hlers. Dieser Band hat das Ziel, das Spektrum der Texte zwischen Autobiographie und Historiographie, mystischen Offenbarungstexten und Traumallegorien, Minnesang und Minnerede sichtbar werden zu lassen. Die Beitr{\"a}ge des Sammelbandes befragen exemplarische Texte des 6. bis 15. Jahrhunderts im Hinblick auf Ph{\"a}nomene des Narrativen in lyrischen Texten, die Rolle, die dem Minnesang, auch als Gegenstand von Zyklusbildungen, bei der Literarisierung und Etablierung des Ich-Erz{\"a}hlens zukommt, Lizenzen und Restriktionen des Erz{\"a}hlens von sich selbst, die Profilierung von Autorrollen, die Funktion der Erz{\"a}hlperspektive f{\"u}r die Verb{\"u}rgung und Geltungsbehauptung von Wissen und f{\"u}r die Darstellung von Erkenntnisprozessen, die wechselseitigen Abh{\"a}ngigkeiten von Erfahrung und Ich- Erz{\"a}hlen sowie die Problematik des Begriffs des Autobiographischen.}, language = {de} } @article{DavidsenKwiatekCharalampidouetal.2017, author = {Davidsen, Joern and Kwiatek, Grzegorz and Charalampidou, Elli-Maria and Goebel, Thomas H. W. and Stanchits, Sergei and Rueck, Marc and Dresen, Georg}, title = {Triggering Processes in Rock Fracture}, series = {Physical review letters}, volume = {119}, journal = {Physical review letters}, publisher = {American Physical Society}, address = {College Park}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.119.068501}, pages = {8}, year = {2017}, abstract = {We study triggering processes in triaxial compression experiments under a constant displacement rate on sandstone and granite samples using spatially located acoustic emission events and their focal mechanisms. We present strong evidence that event-event triggering plays an important role in the presence of large-scale or macrocopic imperfections, while such triggering is basically absent if no significant imperfections are present. In the former case, we recover all established empirical relations of aftershock seismicity including the Gutenberg-Richter relation, a modified version of the Omori-Utsu relation and the productivity relation-despite the fact that the activity is dominated by compaction-type events and triggering cascades have a swarmlike topology. For the Gutenberg-Richter relations, we find that the b value is smaller for triggered events compared to background events. Moreover, we show that triggered acoustic emission events have a focal mechanism much more similar to their associated trigger than expected by chance.}, language = {en} } @article{PhilipowskiGlauch2017, author = {Philipowski, Katharina and Glauch, Sonja}, title = {Vorarbeiten zur Literaturgeschichte und Systematik vormodernen Ich-Erz{\"a}hlens}, series = {Von sich selbst erz{\"a}hlen. Historische Dimensionen des Ich-Erz{\"a}hlens}, journal = {Von sich selbst erz{\"a}hlen. Historische Dimensionen des Ich-Erz{\"a}hlens}, editor = {Glauch, Sonja and Philipowski, Katharina}, publisher = {Universit{\"a}tsverlag Winter}, address = {Heidelberg}, isbn = {978-3-8253-6862-3}, pages = {1 -- 61}, year = {2017}, language = {de} } @article{Philipowski2017, author = {Philipowski, Katharina}, title = {Der Autor als Schwankheld}, series = {Von sich selbst erz{\"a}hlen. Historische Dimensionen des Ich-Erz{\"a}hlens}, journal = {Von sich selbst erz{\"a}hlen. Historische Dimensionen des Ich-Erz{\"a}hlens}, editor = {Glauch, Sonja and Philipowski, Katharina}, publisher = {Universit{\"a}tsverlag Winter}, address = {Heidelberg}, isbn = {978-3-8253-6862-3}, pages = {227 -- 262}, year = {2017}, language = {de} } @article{ReilRosenfeldImholtetal.2017, author = {Reil, Daniela and Rosenfeld, Ulrike and Imholt, Christian and Schmidt, Sabrina and Ulrich, Rainer G. and Eccard, Jana and Jacob, Jens}, title = {Puumala hantavirus infections in bank vole populations}, series = {BMC ecology}, volume = {17}, journal = {BMC ecology}, publisher = {BioMed Central}, address = {London}, issn = {1472-6785}, doi = {10.1186/s12898-017-0118-z}, pages = {13}, year = {2017}, abstract = {Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk}, language = {en} }