@article{HeistermannBogenaFranckeetal.2022, author = {Heistermann, Maik and Bogena, Heye and Francke, Till and G{\"u}ntner, Andreas and Jakobi, Jannis and Rasche, Daniel and Schr{\"o}n, Martin and D{\"o}pper, Veronika and Fersch, Benjamin and Groh, Jannis and Patil, Amol and P{\"u}tz, Thomas and Reich, Marvin and Zacharias, Steffen and Zengerle, Carmen and Oswald, Sascha}, title = {Soil moisture observation in a forested headwater catchment: Combining a dense cosmic-ray neutron sensor network with roving and hydrogravimetry at the TERENO site W{\"u}stebach}, series = {Earth system science data}, volume = {14}, journal = {Earth system science data}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1866-3508}, doi = {10.5194/essd-14-2501-2022}, pages = {2501 -- 2519}, year = {2022}, abstract = {Cosmic-ray neutron sensing (CRNS) has become an effective method to measure soil moisture at a horizontal scale of hundreds of metres and a depth of decimetres. Recent studies proposed operating CRNS in a network with overlapping footprints in order to cover root-zone water dynamics at the small catchment scale and, at the same time, to represent spatial heterogeneity. In a joint field campaign from September to November 2020 (JFC-2020), five German research institutions deployed 15 CRNS sensors in the 0.4 km(2) Wustebach catchment (Eifel mountains, Germany). The catchment is dominantly forested (but includes a substantial fraction of open vegetation) and features a topographically distinct catchment boundary. In addition to the dense CRNS coverage, the campaign featured a unique combination of additional instruments and techniques: hydro-gravimetry (to detect water storage dynamics also below the root zone); ground-based and, for the first time, airborne CRNS roving; an extensive wireless soil sensor network, supplemented by manual measurements; and six weighable lysimeters. Together with comprehensive data from the long-term local research infrastructure, the published data set (available at https://doi.org/10.23728/b2share.756ca0485800474e9dc7f5949c63b872; Heistermann et al., 2022) will be a valuable asset in various research contexts: to advance the retrieval of landscape water storage from CRNS, wireless soil sensor networks, or hydrogravimetry; to identify scale-specific combinations of sensors and methods to represent soil moisture variability; to improve the understanding and simulation of land-atmosphere exchange as well as hydrological and hydrogeological processes at the hillslope and the catchment scale; and to support the retrieval of soil water content from airborne and spaceborne remote sensing platforms.}, language = {en} } @article{FuchsPalmtagJuhlsetal.2022, author = {Fuchs, Matthias and Palmtag, Juri and Juhls, Bennet and Overduin, Pier Paul and Grosse, Guido and Abdelwahab, Ahmed and Bedington, Michael and Sanders, Tina and Ogneva, Olga and Fedorova, Irina and Zimov, Nikita S. and Mann, Paul J. and Strauss, Jens}, title = {High-resolution bathymetry models for the Lena Delta and Kolyma Gulf coastal zones}, series = {Earth system science data}, volume = {14}, journal = {Earth system science data}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1866-3508}, doi = {10.5194/essd-14-2279-2022}, pages = {2279 -- 2301}, year = {2022}, abstract = {Arctic river deltas and deltaic near-shore zones represent important land-ocean transition zones influencing sediment dynamics and nutrient fluxes from permafrost-affected terrestrial ecosystems into the coastal Arctic Ocean. To accurately model fluvial carbon and freshwater export from rapidly changing river catchments as well as assess impacts of future change on the Arctic shelf and coastal ecosystems, we need to understand the sea floor characteristics and topographic variety of the coastal zones. To date, digital bathymetrical data from the poorly accessible, shallow, and large areas of the eastern Siberian Arctic shelves are sparse. We have digitized bathymetrical information for nearly 75 000 locations from large-scale (1 V 25000-1 V 500000) current and historical nautical maps of the Lena Delta and the Kolyma Gulf region in northeastern Siberia. We present the first detailed and seamless digital models of coastal zone bathymetry for both delta and gulf regions in 50 and 200m spatial resolution. We validated the resulting bathymetry layers using a combination of our own water depth measurements and a collection of available depth measurements, which showed a strong correlation (r>0.9). Our bathymetrical models will serve as an input for a high-resolution coupled hydrodynamic-ecosystem model to better quantify fluvial and coastal carbon fluxes to the Arctic Ocean, but they may be useful for a range of other studies related to Arctic delta and near-shore dynamics such as modeling of submarine permafrost, near-shore sea ice, or shelf sediment transport. The new digital high-resolution bathymetry products are available on the PANGAEA data set repository for the Lena Delta (https://doi.org/10.1594/PANGAEA.934045; Fuchs et al., 2021a) and Kolyma Gulf region (https://doi.org/10.1594/PANGAEA.934049; Fuchs et al., 2021b), respectively. Likewise, the depth validation data are available on PANGAEA as well (https://doi.org/10.1594/PANGAEA.933187; Fuchs et al., 2021c).}, language = {en} } @article{JonesGrosseFarquharsonetal.2022, author = {Jones, Benjamin M. and Grosse, Guido and Farquharson, Louise M. and Roy-L{\´e}veill{\´e}e, Pascale and Veremeeva, Alexandra and Kanevskiy, Mikhail Z. and Gaglioti, Benjamin and Breen, Amy L. and Parsekian, Andrew D. and Ulrich, Mathias and Hinkel, Kenneth M.}, title = {Lake and drained lake basin systems in lowland permafrost regions}, series = {Nature reviews earth and environment}, volume = {3}, journal = {Nature reviews earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-138X}, doi = {10.1038/s43017-021-00238-9}, pages = {85 -- 98}, year = {2022}, abstract = {The formation, growth and drainage of lakes in Arctic and boreal lowland permafrost regions influence landscape and ecosystem processes. These lake and drained lake basin (L-DLB) systems occupy >20\% of the circumpolar Northern Hemisphere permafrost region and similar to 50\% of the area below 300 m above sea level. Climate change is causing drastic impacts to L-DLB systems, with implications for permafrost dynamics, ecosystem functioning, biogeochemical processes and human livelihoods in lowland permafrost regions. In this Review, we discuss how an increase in the number of lakes as a result of permafrost thaw and an intensifying hydrologic regime are not currently offsetting the land area gained through lake drainage, enhancing the dominance of drained lake basins (DLBs).The contemporary transition from lakes to DLBs decreases hydrologic storage, leads to permafrost aggradation, increases carbon sequestration and diversifies the shifting habitat mosaic in Arctic and boreal regions. However, further warming could inhibit permafrost aggradation in DLBs, disrupting the trajectory of important microtopographic controls on carbon fluxes and ecosystem processes in permafrost-region L-DLB systems. Further research is needed to understand the future dynamics of L-DLB systems to improve Earth system models, permafrost carbon feedback assessments, permafrost hydrology linkages, infrastructure development in permafrost regions and the well-being of northern socio-ecological systems.}, language = {en} } @article{DerežaninBlažytėDobryninetal.2022, author = {Derežanin, Lorena and Blažytė, Asta and Dobrynin, Pavel and Duch{\^e}ne, David A. and Grau, Jos{\´e} Horacio and Jeon, Sungwon and Kliver, Sergei and Koepfli, Klaus-Peter and Meneghini, Dorina and Preick, Michaela and Tomarovsky, Andrey and Totikov, Azamat and Fickel, J{\"o}rns and F{\"o}rster, Daniel W.}, title = {Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae}, series = {Molecular ecology}, volume = {31}, journal = {Molecular ecology}, number = {10}, publisher = {Wiley}, address = {Hoboken}, issn = {0962-1083}, doi = {10.1111/mec.16443}, pages = {2898 -- 2919}, year = {2022}, abstract = {Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly of the tayra (Eira barbara), the earliest diverging species in the subfamily, and compared this with the genomes available for the wolverine (Gulo gulo) and the sable (Martes zibellina). Our comparative genomic analyses included searching for signs of positive selection, examining changes in gene family sizes and searching for species-specific structural variants. Among candidate loci associated with phenotypic traits, we observed many related to diet, body condition and reproduction. For example, for the tayra, which has an atypical gulonine reproductive strategy of aseasonal breeding, we observed species-specific changes in many pregnancy-related genes. For the wolverine, a circumpolar hypercarnivore that must cope with seasonal food scarcity, we observed many changes in genes associated with diet and body condition. All types of genomic variation examined (single nucleotide polymorphisms, gene family expansions, structural variants) contributed substantially to the identification of candidate loci. This argues strongly for consideration of variation other than single nucleotide polymorphisms in comparative genomics studies aiming to identify loci of adaptive significance.}, language = {en} } @article{AbdelilahSeyfriedIruelaArispePenningeretal.2022, author = {Abdelilah-Seyfried, Salim and Iruela-Arispe, M. Luisa and Penninger, Josef M. and Tournier-Lasserve, Elisabeth and Vikkula, Miikka and Cleaver, Ondine}, title = {Recalibrating vascular malformations and mechanotransduction by pharmacological intervention}, series = {Journal of clinical investigation}, volume = {132}, journal = {Journal of clinical investigation}, number = {8}, publisher = {American Society for Clinical Investigation}, address = {Ann Arbor}, issn = {0021-9738}, doi = {10.1172/JCI160227}, pages = {4}, year = {2022}, language = {en} } @article{ZhangWangKuangetal.2022, author = {Zhang, Zhihao and Wang, Ting and Kuang, Jin and Herold, Fabian and Ludyga, Sebastian and Li, Jingming and Hall, Daniel L. and Taylor, Alyx and Healy, Sean and Yeung, Albert S. and Kramer, Arthur F. and Zou, Liye}, title = {The roles of exercise tolerance and resilience in the effect of physical activity on emotional states among college students}, series = {International Journal of Clinical and Health Psychology}, volume = {22}, journal = {International Journal of Clinical and Health Psychology}, number = {3}, publisher = {Elsevier}, address = {New York}, issn = {1697-2600}, doi = {10.1016/j.ijchp.2022.100312}, pages = {8}, year = {2022}, abstract = {Background/objective: Negative emotional states, such as depression, anxiety, and stress challenge health care due to their long-term consequences for mental disorders. Accumulating evidence indicates that regular physical activity (PA) can positively influence negative emotional states. Among possible candidates, resilience and exercise tolerance in particular have the potential to partly explain the positive effects of PA on negative emotional states. Thus, the aim of this study was to investigate the association between PA and negative emotional states, and further determine the mediating effects of exercise tolerance and resilience in such a relationship. Method: In total, 1117 Chinese college students (50.4\% female, Mage=18.90, SD=1.25) completed a psychosocial battery, including the 21-item Depression Anxiety Stress Scale (DASS-21), the Connor-Davidson Resilience Scale (CD-RISC), the Preference for and Tolerance of the Intensity of Exercise Questionnaire (PRETIE-Q), and the International Physical Activity Questionnaire short form (IPAQ-SF). Regression analysis was used to identify the serial multiple mediation, controlling for gender, age and BMI. Results: PA, exercise intensity-tolerance, and resilience were significantly negatively correlated with negative emotional states (Ps<.05). Further, exercise tolerance and resilience partially mediated the relationship between PA and negative emotional states. Conclusions: Resilience and exercise intensity-tolerance can be achieved through regularly engaging in PA, and these newly observed variables play critical roles in prevention of mental illnesses, especially college students who face various challenges. Recommended amount of PA should be incorporated into curriculum or sport clubs within a campus environment.}, language = {en} } @article{RingEisenmannKandiletal.2022, author = {Ring, Raphaela M. and Eisenmann, Clemens and Kandil, Farid and Steckhan, Nico and Demmrich, Sarah and Klatte, Caroline and Kessler, Christian S. and Jeitler, Michael and Boschmann, Michael and Michalsen, Andreas and Blakeslee, Sarah B. and St{\"o}ckigt, Barbara and Stritter, Wiebke and Koppold-Liebscher, Daniela A.}, title = {Mental and behavioural responses to Bah{\´a}'{\´i} fasting: Looking behind the scenes of a religiously motivated intermittent fast using a mixed methods approach}, series = {Nutrients}, volume = {14}, journal = {Nutrients}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2072-6643}, doi = {10.3390/nu14051038}, pages = {23}, year = {2022}, abstract = {Background/Objective: Historically, fasting has been practiced not only for medical but also for religious reasons. Baha'is follow an annual religious intermittent dry fast of 19 days. We inquired into motivation behind and subjective health impacts of Baha'i fasting. Methods: A convergent parallel mixed methods design was embedded in a clinical single arm observational study. Semi-structured individual interviews were conducted before (n = 7), during (n = 8), and after fasting (n = 8). Three months after the fasting period, two focus group interviews were conducted (n = 5/n = 3). A total of 146 Baha'i volunteers answered an online survey at five time points before, during, and after fasting. Results: Fasting was found to play a central role for the religiosity of interviewees, implying changes in daily structures, spending time alone, engaging in religious practices, and experiencing social belonging. Results show an increase in mindfulness and well-being, which were accompanied by behavioural changes and experiences of self-efficacy and inner freedom. Survey scores point to an increase in mindfulness and well-being during fasting, while stress, anxiety, and fatigue decreased. Mindfulness remained elevated even three months after the fast. Conclusion: Baha'i fasting seems to enhance participants' mindfulness and well-being, lowering stress levels and reducing fatigue. Some of these effects lasted more than three months after fasting.}, language = {en} } @article{CaoTianHerzschuhetal.2022, author = {Cao, Xianyong and Tian, Fang and Herzschuh, Ulrike and Ni, Jian and Xu, Qinghai and Li, Wenjia and Zhang, Yanrong and Luo, Mingyu and Chen, Fahu}, title = {Human activities have reduced plant diversity in eastern China over the last two millennia}, series = {Global change biology}, volume = {28}, journal = {Global change biology}, number = {16}, publisher = {Wiley}, address = {Hoboken}, issn = {1354-1013}, doi = {10.1111/gcb.16274}, pages = {4962 -- 4976}, year = {2022}, abstract = {Understanding the history and regional singularities of human impact on vegetation is key to developing strategies for sustainable ecosystem management. In this study, fossil and modern pollen datasets from China are employed to investigate temporal changes in pollen composition, analogue quality, and pollen diversity during the Holocene. Anthropogenic disturbance and vegetation's responses are also assessed. Results reveal that pollen assemblages from non-forest communities fail to provide evidence of human impact for the western part of China (annual precipitation less than 400 mm and/or elevation more than 3000 m.a.s.l.), as inferred from the stable quality of modern analogues, principal components, and diversity of species and communities throughout the Holocene. For the eastern part of China, the proportion of fossil pollen spectra with good modern analogues increases from ca. 50\% to ca. 80\% during the last 2 millennia, indicating an enhanced intensity of anthropogenic disturbance on vegetation. This disturbance has caused the pollen spectra to become taxonomically less diverse over space (reduced abundances of arboreal taxa and increased abundances of herbaceous taxa), highlighting a reduced south-north differentiation and divergence from past vegetation between regions in the eastern part of China. We recommend that care is taken in eastern China when basing the development of ecosystem management strategies on vegetation changes in the region during the last 2000 years, since humans have significantly disturbed the vegetation during this period.}, language = {en} } @article{SarrDonnadieuBoltonetal.2022, author = {Sarr, Anta-Clarisse and Donnadieu, Yannick and Bolton, Clara T. and Ladant, Jean-Baptiste and Licht, Alexis and Fluteau, Fr{\´e}d{\´e}ric and Laugi{\´e}, Marie and Tardif, Delphine and Dupont-Nivet, Guillaume}, title = {Neogene South Asian monsoon rainfall and wind histories diverged due to topographic effects}, series = {Nature geoscience}, volume = {15}, journal = {Nature geoscience}, number = {4}, publisher = {Nature Research}, address = {Berlin}, issn = {1752-0894}, doi = {10.1038/s41561-022-00919-0}, pages = {314 -- 319}, year = {2022}, abstract = {The drivers of the evolution of the South Asian Monsoon remain widely debated. An intensification of monsoonal rainfall recorded in terrestrial and marine sediment archives from the earliest Miocene (23-20 million years ago (Ma)) is generally attributed to Himalayan uplift. However, Indian Ocean palaeorecords place the onset of a strong monsoon around 13 Ma, linked to strengthening of the southwesterly winds of the Somali Jet that also force Arabian Sea upwelling. Here we reconcile these divergent records using Earth system model simulations to evaluate the interactions between palaeogeography and ocean-atmosphere dynamics. We show that factors forcing the South Asian Monsoon circulation versus rainfall are decoupled and diachronous. Himalayan and Tibetan Plateau topography predominantly controlled early Miocene rainfall patterns, with limited impact on ocean-atmosphere circulation. The uplift of the East African and Middle Eastern topography played a pivotal role in the establishment of the modern Somali Jet structure above the western Indian Ocean, while strong upwelling initiated as a direct consequence of the emergence of the Arabian Peninsula and the onset of modern-like atmospheric circulation. Our results emphasize that although elevated rainfall seasonality was probably a persistent feature since the India-Asia collision in the Paleogene, modern-like monsoonal atmospheric circulation only emerged in the late Neogene.}, language = {en} } @article{BarcenaAslamPozdniakovaetal.2022, author = {Barcena, Maria Luisa and Aslam, Muhammad and Pozdniakova, Sofya and Norman, Kristina and Ladilov, Yury}, title = {Cardiovascular inflammaging: mechanisms and translational aspects}, series = {Cells}, volume = {11}, journal = {Cells}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells11061010}, pages = {15}, year = {2022}, abstract = {Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.}, language = {en} } @article{GiannettiUmanskySened2022, author = {Giannetti, Daniela and Umansky, Karen and Sened, Itai}, title = {The entry of the M5S and the reshaping of party politics in Italy (2008-2018)}, series = {Government \& opposition}, volume = {59}, journal = {Government \& opposition}, number = {2}, publisher = {Cambridge University Press}, address = {Cambridge}, issn = {0017-257X}, doi = {10.1017/gov.2022.38}, pages = {464 -- 481}, year = {2022}, abstract = {This article examines how challenger parties enter the political arena and the effect of this entry by looking at the Italian 5 Star Movement (Movimento 5 Stelle - M5S). We explain the M5S's entry strategy in 2013 using the spatial approach to party competition and employing expert survey data collected for each national election between 2008 and 2018. These data allow us to analyse the changing spatial configuration of Italian politics due to the increasing salience of pro/anti-EU and pro/anti-immigration dimensions. We then apply the theoretical notion of the uncovered set (UCS) to trace how the M5S's entry reshaped the overall space of party competition, causing a realignment of existing parties. This work contributes to the ongoing debate on the electoral success of challenger parties and the emerging cleavages and polarization of party systems in Western European countries.}, language = {en} } @article{MarinBeloquiZhangGuoetal.2022, author = {Marin-Beloqui, Jose and Zhang, Guanran and Guo, Junjun and Shaikh, Jordan and Wohrer, Thibaut and Hosseini, Seyed Mehrdad and Sun, Bowen and Shipp, James and Auty, Alexander J. and Chekulaev, Dimitri and Ye, Jun and Chin, Yi-Chun and Sullivan, Michael B. and Mozer, Attila J. and Kim, Ji-Seon and Shoaee, Safa and Clarke, Tracey M.}, title = {Insight into the origin of trapping in polymer/fullerene blends with a systematic alteration of the fullerene to higher adducts}, series = {Journal of physical chemistry C}, volume = {126}, journal = {Journal of physical chemistry C}, number = {5}, publisher = {American Chemical Society}, address = {Washington}, issn = {1932-7447}, doi = {10.1021/acs.jpcc.1c10378}, pages = {2708 -- 2719}, year = {2022}, abstract = {The bimolecular recombination characteristics of conjugated polymer poly[(4,4'-bis(2-ethylhexyl)dithieno[3,2-b:2',3'-d]silole)-2,6-diyl-alt-(2,5-bis 3-tetradecylthiophen-2-y1 thiazolo 5,4-d thiazole)-2,5diy1] (PDTSiTTz) blended with the fullerene series PC60BM, ICMA, ICBA, and ICTA have been investigated using microsecond and femtosecond transient absorption spectroscopy, in conjunction with electroluminescence measurements and ambient photoemission spectroscopy. The non-Langevin polymer PDTSiTTz allows an inspection of intrinsic bimolecular recombination rates uninhibited by diffusion, while the low oscillator strengths of fullerenes allow polymer features to dominate, and we compare our results to those of the well-known polymer Si-PCPDTBT. Using mu s-TAS, we have shown that the trap -limited decay dynamics of the PDTSiTTz polaron becomes progressively slower across the fullerene series, while those of Si-PCPDTBT are invariant. Electroluminescence measurements showed an unusual double peak in pristine PDTSiTTz, attributed to a low energy intragap charge transfer state, likely interchain in nature. Furthermore, while the pristine PDTSiTTz showed a broad, low-intensity density of states, the ICBA and ICTA blends presented a virtually identical DOS to Si-PCPDTBT and its blends. This has been attributed to a shift from a delocalized, interchain highest occupied molecular orbital (HOMO) in the pristine material to a dithienosilole-centered HOMO in the blends, likely a result of the bulky fullerenes increasing interchain separation. This HOMO localization had a side effect of progressively shifting the polymer HOMO to shallower energies, which was correlated with the observed decrease in bimolecular recombination rate and increased "trap" depth. However, since the density of tail states remained the same, this suggests that the traditional viewpoint of "trapping" being dominated by tail states may not encompass the full picture and that the breadth of the DOS may also have a strong influence on bimolecular recombination.}, language = {en} } @article{FlovenzWangHersiretal.2022, author = {Fl{\´o}venz, {\´O}lafur G. and Wang, Rongjiang and Hersir, Gylfi P{\´a}ll and Dahm, Torsten and Hainzl, Sebastian and Vassileva, Magdalena and Drouin, Vincent and Heimann, Sebastian and Isken, Marius Paul and Gudnason, Egill {\´A}. and {\´A}g{\´u}stsson, Kristj{\´a}n and {\´A}g{\´u}stsd{\´o}ttir, Thorbj{\"o}rg and Hor{\´a}lek, Josef and Motagh, Mahdi and Walter, Thomas R. and Rivalta, Eleonora and Jousset, Philippe and Krawczyk, Charlotte M. and Milkereit, Claus}, title = {Cyclical geothermal unrest as a precursor to Iceland's 2021 Fagradalsfjall eruption}, series = {Nature geoscience}, volume = {15}, journal = {Nature geoscience}, number = {5}, publisher = {Nature Research}, address = {Berlin}, issn = {1752-0894}, doi = {10.1038/s41561-022-00930-5}, pages = {397 -- 404}, year = {2022}, abstract = {Understanding and constraining the source of geodetic deformation in volcanic areas is an important component of hazard assessment. Here, we analyse deformation and seismicity for one year before the March 2021 Fagradalsfjall eruption in Iceland. We generate a high-resolution catalogue of 39,500 earthquakes using optical cable recordings and develop a poroelastic model to describe three pre-eruptional uplift and subsidence cycles at the Svartsengi geothermal field, 8 km west of the eruption site. We find the observed deformation is best explained by cyclic intrusions into a permeable aquifer by a fluid injected at 4 km depth below the geothermal field, with a total volume of 0.11 ± 0.05 km3 and a density of 850 ± 350 kg m-3. We therefore suggest that ingression of magmatic CO2 can explain the geodetic, gravity and seismic data, although some contribution of magma cannot be excluded.}, language = {en} } @article{KayaDupontNivetFrielingetal.2022, author = {Kaya, Mustafa Y{\"u}cel and Dupont-Nivet, Guillaume and Frieling, Joost and Fioroni, Chiara and Rohrmann, Alexander and Alt{\i}ner, Sevin{\c{c}} {\"O}zkan and Vardar, Ezgi and Tanyas, Hakan and Mamtimin, Mehmut and Zhaojie, Guo}, title = {The Eurasian epicontinental sea was an important carbon sink during the Palaeocene-Eocene thermal maximum}, series = {Communications earth and environment}, volume = {3}, journal = {Communications earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-4435}, doi = {10.1038/s43247-022-00451-4}, pages = {10}, year = {2022}, abstract = {The Palaeocene-Eocene Thermal Maximum (ca. 56 million years ago) offers a primary analogue for future global warming and carbon cycle recovery. Yet, where and how massive carbon emissions were mitigated during this climate warming event remains largely unknown. Here we show that organic carbon burial in the vast epicontinental seaways that extended over Eurasia provided a major carbon sink during the Palaeocene-Eocene Thermal Maximum. We coupled new and existing stratigraphic analyses to a detailed paleogeographic framework and using spatiotemporal interpolation calculated ca. 720-1300 Gt organic carbon excess burial, focused in the eastern parts of the Eurasian epicontinental seaways. A much larger amount (2160-3900 Gt C, and when accounting for the increase in inundated shelf area 7400-10300 Gt C) could have been sequestered in similar environments globally. With the disappearance of most epicontinental seas since the Oligocene-Miocene, an effective negative carbon cycle feedback also disappeared making the modern carbon cycle critically dependent on the slower silicate weathering feedback.}, language = {en} } @article{KloseGuillemoteauVignolietal.2023, author = {Klose, Tim and Guillemoteau, Julien and Vignoli, Giulio and Walter, Judith and Herrmann, Andreas and Tronicke, Jens}, title = {Structurally constrained inversion by means of a Minimum Gradient Support regularizer}, series = {Geophysical journal international}, volume = {233}, journal = {Geophysical journal international}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggad041}, pages = {1938 -- 1949}, year = {2023}, abstract = {Many geophysical inverse problems are known to be ill-posed and, thus, requiring some kind of regularization in order to provide a unique and stable solution. A possible approach to overcome the inversion ill-posedness consists in constraining the position of the model interfaces. For a grid-based parameterization, such a structurally constrained inversion can be implemented by adopting the usual smooth regularization scheme in which the local weight of the regularization is reduced where an interface is expected. By doing so, sharp contrasts are promoted at interface locations while standard smoothness constraints keep affecting the other regions of the model. In this work, we present a structurally constrained approach and test it on the inversion of frequency-domain electromagnetic induction (FD-EMI) data using a regularization approach based on the Minimum Gradient Support stabilizer, which is capable to promote sharp transitions everywhere in the model, i.e., also in areas where no structural a prioriinformation is available. Using 1D and 2D synthetic data examples, we compare the proposed approach to a structurally constrained smooth inversion as well as to more standard (i.e., not structurally constrained) smooth and sharp inversions. Our results demonstrate that the proposed approach helps in finding a better and more reliable reconstruction of the subsurface electrical conductivity distribution, including its structural characteristics. Furthermore, we demonstrate that it allows to promote sharp parameter variations in areas where no structural information are available. Lastly, we apply our structurally constrained scheme to FD-EMI field data collected at a field site in Eastern Germany to image the thickness of peat deposits along two selected profiles. In this field example, we use collocated constant offset ground-penetrating radar (GPR) data to derive structural a priori information to constrain the inversion of the FD-EMI data. The results of this case study demonstrate the effectiveness and flexibility of the proposed approach.}, language = {en} } @article{CordobaTongBurgosetal.2023, author = {C{\´o}rdoba, Sandra Correa and Tong, Hao and Burgos, Asdrubal and Zhu, Feng and Alseekh, Saleh and Fernie, Alisdair R. and Nikoloski, Zoran}, title = {Identification of gene function based on models capturing natural variability of Arabidopsis thaliana lipid metabolism}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-40644-9}, pages = {12}, year = {2023}, abstract = {The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architecture of lipid metabolism. Lipids play fundamental roles in regulating agronomically important traits. Advances in plant lipid metabolism have until recently largely been based on reductionist approaches, although modulation of its components can have system-wide effects. However, existing models of plant lipid metabolism provide lumped representations, hindering detailed study of component modulation. Here, we present the Plant Lipid Module (PLM) which provides a mechanistic description of lipid metabolism in the Arabidopsis thaliana rosette. We demonstrate that the PLM can be readily integrated in models of A. thaliana Col-0 metabolism, yielding accurate predictions (83\%) of single lethal knock-outs and 75\% concordance between measured transcript and predicted flux changes under extended darkness. Genome-wide associations with fluxes obtained by integrating the PLM in diel condition- and accession-specific models identify up to 65 candidate genes modulating A. thaliana lipid metabolism. Using mutant lines, we validate up to 40\% of the candidates, paving the way for identification of metabolic gene function based on models capturing natural variability in metabolism.}, language = {en} } @article{CescaSuganRudzinskietal.2022, author = {Cesca, Simone and Sugan, Monica and Rudzinski, Lukasz and Vajedian, Sanaz and Niemz, Peter and Plank, Simon and Petersen, Gesa and Deng, Zhiguo and Rivalta, Eleonora and Vuan, Alessandro and Linares, Milton Percy Plasencia and Heimann, Sebastian and Dahm, Torsten}, title = {Massive earthquake swarm driven by magmatic intrusion at the Bransfield Strait, Antarctica}, series = {Communications earth and environment}, volume = {3}, journal = {Communications earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-4435}, doi = {10.1038/s43247-022-00418-5}, pages = {11}, year = {2022}, abstract = {An earthquake swarm affected the Bransfield Strait, Antarctica, a unique rift basin in transition from intra-arc rifting to ocean spreading. The swarm, counting similar to 85,000 volcano-tectonic earthquakes since August 2020, is located close to the Orca submarine volcano, previously considered inactive. Simultaneously, geodetic data reported up to similar to 11 cm north-westward displacement over King George Island. We use a broad variety of geophysical data and methods to reveal the complex migration of seismicity, accompanying the intrusion of 0.26-0.56 km(3) of magma. Strike-slip earthquakes mark the intrusion at depth, while shallower normal faulting the similar to 20 km long lateral growth of a dike. Seismicity abruptly decreased after a Mw 6.0 earthquake, suggesting the magmatic dike lost pressure with the slipping of a large fault. A seafloor eruption is likely, but not confirmed by sea surface temperature anomalies. The unrest documents episodic magmatic intrusion in the Bransfield Strait, providing unique insights into active continental rifting.}, language = {en} } @article{BouamraZouhalRateletal.2022, author = {Bouamra, Marwa and Zouhal, Hassane and Ratel, S{\´e}bastien and Makhlouf, Issam and Bezrati, Ikram and Chtara, Mokhtar and Behm, David G. and Granacher, Urs and Chaouachi, Anis}, title = {Concurrent training promotes greater gains on body composition and components of physical fitness than single-mode training (endurance or resistance) in youth with obesity}, series = {Frontiers in physiology}, volume = {13}, journal = {Frontiers in physiology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2022.869063}, pages = {16}, year = {2022}, abstract = {The prevalence of obesity in the pediatric population has become a major public health issue. Indeed, the dramatic increase of this epidemic causes multiple and harmful consequences, Physical activity, particularly physical exercise, remains to be the cornerstone of interventions against childhood obesity. Given the conflicting findings with reference to the relevant literature addressing the effects of exercise on adiposity and physical fitness outcomes in obese children and adolescents, the effect of duration-matched concurrent training (CT) [50\% resistance (RT) and 50\% high-intensity-interval-training (HIIT)] on body composition and physical fitness in obese youth remains to be elucidated. Thus, the purpose of this study was to examine the effects of 9-weeks of CT compared to RT or HIIT alone, on body composition and selected physical fitness components in healthy sedentary obese youth. Out of 73 participants, only 37; [14 males and 23 females; age 13.4 +/- 0.9 years; body-mass-index (BMI): 31.2 +/- 4.8 kg center dot m-2] were eligible and randomized into three groups: HIIT (n = 12): 3-4 setsx12 runs at 80-110\% peak velocity, with 10-s passive recovery between bouts; RT (n = 12): 6 exercises; 3-4 sets x 10 repetition maximum (RM) and CT (n = 13): 50\% serial completion of RT and HIIT. CT promoted significant greater gains compared to HIIT and RT on body composition (p < 0.01, d = large), 6-min-walking test distance (6 MWT-distance) and on 6 MWT-VO2max (p < 0.03, d = large). In addition, CT showed substantially greater improvements than HIIT in the medicine ball throw test (20.2 vs. 13.6\%, p < 0.04, d = large). On the other hand, RT exhibited significantly greater gains in relative hand grip strength (p < 0.03, d = large) and CMJ (p < 0.01, d = large) than HIIT and CT. CT promoted greater benefits for fat, body mass loss and cardiorespiratory fitness than HIIT or RT modalities. This study provides important information for practitioners and therapists on the application of effective exercise regimes with obese youth to induce significant and beneficial body composition changes. The applied CT program and the respective programming parameters in terms of exercise intensity and volume can be used by practitioners as an effective exercise treatment to fight the pandemic overweight and obesity in youth.}, language = {en} } @article{ChengDennisOsuohaetal.2023, author = {Cheng, Feng and Dennis, Alice B. and Osuoha, Josephine Ijeoma and Canitz, Julia and Kirschbaum, Frank and Tiedemann, Ralph}, title = {A new genome assembly of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha}, series = {BMC genomics}, volume = {24}, journal = {BMC genomics}, number = {1}, publisher = {BMC}, address = {London}, issn = {1471-2164}, doi = {10.1186/s12864-023-09196-6}, pages = {13}, year = {2023}, abstract = {Background Teleost fishes comprise more than half of the vertebrate species. Within teleosts, most phylogenies consider the split between Osteoglossomorpha and Euteleosteomorpha/Otomorpha as basal, preceded only by the derivation of the most primitive group of teleosts, the Elopomorpha. While Osteoglossomorpha are generally species poor, the taxon contains the African weakly electric fish (Mormyroidei), which have radiated into numerous species. Within the mormyrids, the genus Campylomormyrus is mostly endemic to the Congo Basin. Campylomormyrus serves as a model to understand mechanisms of adaptive radiation and ecological speciation, especially with regard to its highly diverse species-specific electric organ discharges (EOD). Currently, there are few well-annotated genomes available for electric fish in general and mormyrids in particular. Our study aims at producing a high-quality genome assembly and to use this to examine genome evolution in relation to other teleosts. This will facilitate further understanding of the evolution of the osteoglossomorpha fish in general and of electric fish in particular. Results A high-quality weakly electric fish (C. compressirostris) genome was produced from a single individual with a genome size of 862 Mb, consisting of 1,497 contigs with an N50 of 1,399 kb and a GC-content of 43.69\%. Gene predictions identified 34,492 protein-coding genes, which is a higher number than in the two other available Osteoglossomorpha genomes of Paramormyrops kingsleyae and Scleropages formosus. A Computational Analysis of gene Family Evolution (CAFE5) comparing 33 teleost fish genomes suggests an overall faster gene family turnover rate in Osteoglossomorpha than in Otomorpha and Euteleosteomorpha. Moreover, the ratios of expanded/contracted gene family numbers in Osteoglossomorpha are significantly higher than in the other two taxa, except for species that had undergone an additional genome duplication (Cyprinus carpio and Oncorhynchus mykiss). As potassium channel proteins are hypothesized to play a key role in EOD diversity among species, we put a special focus on them, and manually curated 16 Kv1 genes. We identified a tandem duplication in the KCNA7a gene in the genome of C. compressirostris. Conclusions We present the fourth genome of an electric fish and the third well-annotated genome for Osteoglossomorpha, enabling us to compare gene family evolution among major teleost lineages. Osteoglossomorpha appear to exhibit rapid gene family evolution, with more gene family expansions than contractions. The curated Kv1 gene family showed seven gene clusters, which is more than in other analyzed fish genomes outside Osteoglossomorpha. The KCNA7a, encoding for a potassium channel central for EOD production and modulation, is tandemly duplicated which may related to the diverse EOD observed among Campylomormyrus species.}, language = {en} } @article{RosinLaiMouldetal.2022, author = {Rosin, Paul L. and Lai, Yu-Kun and Mould, David and Yi, Ran and Berger, Itamar and Doyle, Lars and Lee, Seungyong and Li, Chuan and Liu, Yong-Jin and Semmo, Amir and Shamir, Ariel and Son, Minjung and Winnem{\"o}ller, Holger}, title = {NPRportrait 1.0: A three-level benchmark for non-photorealistic rendering of portraits}, series = {Computational visual media}, volume = {8}, journal = {Computational visual media}, number = {3}, publisher = {Springer Nature}, address = {London}, issn = {2096-0433}, doi = {10.1007/s41095-021-0255-3}, pages = {445 -- 465}, year = {2022}, abstract = {Recently, there has been an upsurge of activity in image-based non-photorealistic rendering (NPR), and in particular portrait image stylisation, due to the advent of neural style transfer (NST). However, the state of performance evaluation in this field is poor, especially compared to the norms in the computer vision and machine learning communities. Unfortunately, the task of evaluating image stylisation is thus far not well defined, since it involves subjective, perceptual, and aesthetic aspects. To make progress towards a solution, this paper proposes a new structured, three-level, benchmark dataset for the evaluation of stylised portrait images. Rigorous criteria were used for its construction, and its consistency was validated by user studies. Moreover, a new methodology has been developed for evaluating portrait stylisation algorithms, which makes use of the different benchmark levels as well as annotations provided by user studies regarding the characteristics of the faces. We perform evaluation for a wide variety of image stylisation methods (both portrait-specific and general purpose, and also both traditional NPR approaches and NST) using the new benchmark dataset.}, language = {en} } @article{IrrgangBendixenFarquharsonetal.2022, author = {Irrgang, Anna M. and Bendixen, Mette and Farquharson, Louise M. and Baranskaya, Alisa and Erikson, Li H. and Gibbs, Ann E. and Ogorodov, Stanislav A. and Overduin, Pier Paul and Lantuit, Hugues and Grigoriev, Mikhail N. and Jones, Benjamin M.}, title = {Drivers, dynamics and impacts of changing Arctic coasts}, series = {Nature reviews earth and environment}, volume = {3}, journal = {Nature reviews earth and environment}, number = {1}, publisher = {Nature Research}, address = {London}, issn = {2662-138X}, doi = {10.1038/s43017-021-00232-1}, pages = {39 -- 54}, year = {2022}, abstract = {Arctic coasts are vulnerable to the effects of climate change, including rising sea levels and the loss of permafrost, sea ice and glaciers. Assessing the influence of anthropogenic warming on Arctic coastal dynamics, however, is challenged by the limited availability of observational, oceanographic and environmental data. Yet, with the majority of permafrost coasts being erosive, coupled with projected intensification of erosion and flooding, understanding these changes is critical. In this Review, we describe the morphological diversity of Arctic coasts, discuss important drivers of coastal change, explain the specific sensitivity of Arctic coasts to climate change and provide an overview of pan-Arctic shoreline change and its multifaceted impacts. Arctic coastal changes impact the human environment by threatening coastal settlements, infrastructure, cultural sites and archaeological remains. Changing sediment fluxes also impact the natural environment through carbon, nutrient and pollutant release on a magnitude that remains difficult to predict. Increasing transdisciplinary and interdisciplinary collaboration efforts will build the foundation for identifying sustainable solutions and adaptation strategies to reduce future risks for those living on, working at and visiting the rapidly changing Arctic coast.}, language = {en} } @article{IzotovChisholmWorsecketal.2022, author = {Izotov, Yuri I. and Chisholm, John and Worseck, G{\´a}bor and Guseva, Natalia G. and Schaerer, Daniel and Prochaska, Jason Xavier}, title = {Lyman alpha and Lyman continuum emission of Mg II-selected star-forming galaxies}, series = {Monthly notices of the Royal Astronomical Society}, volume = {515}, journal = {Monthly notices of the Royal Astronomical Society}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stac1899}, pages = {2864 -- 2881}, year = {2022}, abstract = {We present observations with the Cosmic Origins Spectrograph onboard the Hubble Space Telescope of seven compact low-mass star-forming galaxies at redshifts, z, in the range 0.3161-0.4276, with various O3Mg2 = [O III] lambda 5007/Mg II lambda 2796+2803 and Mg-2 = Mg II lambda 2796/Mg II lambda 2803 emission-line ratios. We aim to study the dependence of leaking Lyman continuum (LyC) emission on the characteristics of Mg ii emission together with the dependencies on other indirect indicators of escaping ionizing radiation. LyC emission with escape fractions f(esc)(LyC) = 3.1-4.6 per cent is detected in four galaxies, whereas only 1 sigma upper limits of f(esc)(LyC) in the remaining three galaxies were derived. A strong narrow Ly alpha emission line with two peaks separated by V-sep similar to 298-592 km s(-1) was observed in four galaxies with detected LyC emission and very weak Ly alpha emission is observed in galaxies with LyC non-detections. Our new data confirm the tight anticorrelation between f(esc)(LyC) and V-sep found for previous low-redshift galaxy samples. V-sep remains the best indirect indicator of LyC leakage among all considered indicators. It is found that escaping LyC emission is detected predominantly in galaxies with Mg-2 greater than or similar to 1.3. A tendency of an increase of f(esc)(LyC) with increasing of both the O3Mg2 and Mg-2 is possibly present. However, there is substantial scatter in these relations not allowing their use for reliable prediction of f(esc)(LyC).}, language = {en} } @article{BereswillGatzMillerSuetal.2023, author = {Bereswill, Sarah and Gatz-Miller, Hannah and Su, Danyang and T{\"o}tzke, Christian and Kardjilov, Nikolay and Oswald, Sascha and Mayer, Klaus Ulrich}, title = {Coupling non-invasive imaging and reactive transport modeling to investigate water and oxygen dynamics in the root zone}, series = {Vadose zone journal}, volume = {22}, journal = {Vadose zone journal}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {1539-1663}, doi = {10.1002/vzj2.20268}, pages = {19}, year = {2023}, abstract = {Oxygen (O-2) availability in soils is vital for plant growth and productivity. The transport and consumption of O-2 in the root zone is closely linked to soil moisture content, the spatial distribution of roots, as well as structure and heterogeneity of the surrounding soil. In this study, we measure three-dimensional root system architecture and the spatiotemporal dynamics of soil moisture (\& theta;) and O-2 concentrations in the root zone of maize (Zea mays) via non-invasive imaging, and then construct and parameterize a reactive transport model based on the experimental data. The combination of three non-invasive imaging methods allowed for a direct comparison of simulation results with observations at high spatial and temporal resolution. In three different modeling scenarios, we investigated how the results obtained for different levels of conceptual complexity in the model were able to match measured \& theta; and O-2 concentration patterns. We found that the modeling scenario that considers heterogeneous soil structure and spatial variability of hydraulic parameters (permeability, porosity, and van Genuchten \& alpha; and n), better reproduced the measured \& theta; and O-2 patterns relative to a simple model with a homogenous soil domain. The results from our combined imaging and modeling analysis reveal that experimental O-2 and water dynamics can be reproduced quantitatively in a reactive transport model, and that O-2 and water dynamics are best characterized when conditions unique to the specific system beyond the distribution of roots, such as soil structure and its effect on water saturation and macroscopic gas transport pathways, are considered.}, language = {en} } @article{VitaglianoHameedJiangetal.2023, author = {Vitagliano, Gerardo and Hameed, Mazhar and Jiang, Lan and Reisener, Lucas and Wu, Eugene and Naumann, Felix}, title = {Pollock: A Data Loading Benchmark}, series = {Proceedings of the VLDB Endowment}, volume = {16}, journal = {Proceedings of the VLDB Endowment}, number = {8}, publisher = {Association for Computing Machinery}, address = {New York}, issn = {2150-8097}, doi = {10.14778/3594512.3594518}, pages = {1870 -- 1882}, year = {2023}, abstract = {Any system at play in a data-driven project has a fundamental requirement: the ability to load data. The de-facto standard format to distribute and consume raw data is CSV. Yet, the plain text and flexible nature of this format make such files often difficult to parse and correctly load their content, requiring cumbersome data preparation steps. We propose a benchmark to assess the robustness of systems in loading data from non-standard CSV formats and with structural inconsistencies. First, we formalize a model to describe the issues that affect real-world files and use it to derive a systematic lpollutionz process to generate dialects for any given grammar. Our benchmark leverages the pollution framework for the csv format. To guide pollution, we have surveyed thousands of real-world, publicly available csv files, recording the problems we encountered. We demonstrate the applicability of our benchmark by testing and scoring 16 different systems: popular csv parsing frameworks, relational database tools, spreadsheet systems, and a data visualization tool.}, language = {en} } @article{Borysek2022, author = {Bor{\´y}sek, Martin}, title = {In search of Ovidian hebrew}, series = {Acta Universitatis Carolinae : AUC}, journal = {Acta Universitatis Carolinae : AUC}, number = {4}, publisher = {Karolinum Press}, address = {Prag}, issn = {0567-8269}, doi = {10.14712/24646830.2022.11}, pages = {29 -- 56}, year = {2022}, abstract = {This paper focuses on the first substantial translation of Ovid's Metamorphoses into modern Hebrew, whose author was Yehoshua Friedman (1885-1934). The first part of the paper sets Friedman into the context of modern Hebrew classical philology and explores the character of his verse. The core of the text consists of three case studies of selected excerpts from Ovid's story of Apollo and Daphne (Met. I, 456-465; 481-482; 545-552). Based on detailed linguistic and stylistic analysis of these texts, I argue that Friedman did not simply adopt a pre-existing linguistic register, but rather created an original Ovidian idiom that helped to win him lasting significance in the history of Hebrew translations from classical languages.}, language = {en} } @article{Zakrzewski2023, author = {Zakrzewski, Tanja}, title = {Miguel de Luna as arbitrista}, series = {Hamsa : journal of Judaic and Islamic studies : revista de estudos judaicos e isl{\^a}micos}, journal = {Hamsa : journal of Judaic and Islamic studies : revista de estudos judaicos e isl{\^a}micos}, number = {9}, publisher = {Universidade de {\´E}vora}, address = {{\´E}vora}, issn = {2183-2633}, doi = {10.4000/hamsa.4231}, pages = {1 -- 13}, year = {2023}, abstract = {This article deals with Miguel de Luna, a Morisco from Granada, who is most famous for his involvement in the Lead Books of Sacromonte affair. In the following pages I will, however, focus on a facet of his life that has been rather neglected. Rather than recount again his activities as translator for Arabic, I will shed light on his work as physician and claim that his medical paper on the benefits of bathing and the reopening of public baths in Granada may very well put him in league with the arbitristas, a group of intellectuals who advised the monarch in economic and financial matters.}, language = {en} } @article{Liberatoscioli2023, author = {Liberatoscioli, Davide}, title = {The new testament and the qur'an as depicted in Abraham Silveira's 'Telling' Mute book}, series = {European Judaism : a journal for the new Europe}, volume = {56}, journal = {European Judaism : a journal for the new Europe}, number = {2}, publisher = {Berghahn}, address = {Oxford}, issn = {0014-3006}, doi = {10.3167/ej.2023.560206}, pages = {47 -- 61}, year = {2023}, abstract = {Interfaith controversies and disputes regarding the role of reason in interpreting the Scriptures characterised scholarly discussion in the Low Countries between the seventeenth and eighteenth centuries. The Jewish author Abraham G{\´o}mez Silveira contributed to this discussion with an eclectic body of literature. This article focuses on his Libro Mudo (Mute Book), which embodies his efforts to present the Jewish religion as the only rational one and the Christian dogma as irrational. In order to corroborate his reading, Silveira mostly bases his argumentation on non-Jewish texts. By selecting passages from the New Testaments, Christian religious commentaries as well as Qur'anic excerpts, Silveira aims to demonstrate that even non-Jewish sources prove the rationality of the Jewish theological system. The novelty of Silveira's approach consists in confuting Christian dogma by accepting the Gospels as reliable historical sources. In this argumentative structure, the Qur'an has a similar although not identical function.}, language = {en} } @article{BrinkmannBeckerZimmermannetal.2022, author = {Brinkmann, Kai Oliver and Becker, Tim and Zimmermann, Florian and Kreusel, Cedric and Gahlmann, Tobias and Theisen, Manuel and Haeger, Tobias and Olthof, Selina and T{\"u}ckmantel, Christian and G{\"u}nster, M. and Maschwitz, Timo and G{\"o}belsmann, Fabian and Koch, Christine and Hertel, Dirk and Caprioglio, Pietro and Pe{\~n}a-Camargo, Francisco and Perdig{\´o}n-Toro, Lorena and Al-Ashouri, Amran and Merten, Lena and Hinderhofer, Alexander and Gomell, Leonie and Zhang, Siyuan and Schreiber, Frank and Albrecht, Steve and Meerholz, Klaus and Neher, Dieter and Stolterfoht, Martin and Riedl, Thomas}, title = {Perovskite-organic tandem solar cells with indium oxide interconnect}, series = {Nature}, volume = {604}, journal = {Nature}, number = {7905}, publisher = {Nature Research}, address = {Berlin}, issn = {0028-0836}, doi = {10.1038/s41586-022-04455-0}, pages = {280 -- 286}, year = {2022}, abstract = {Multijunction solar cells can overcome the fundamental efficiency limits of single-junction devices. The bandgap tunability of metal halide perovskite solar cells renders them attractive for multijunction architectures(1). Combinations with silicon and copper indium gallium selenide (CIGS), as well as all-perovskite tandem cells, have been reported(2-5). Meanwhile, narrow-gap non-fullerene acceptors have unlocked skyrocketing efficiencies for organic solar cells(6,7). Organic and perovskite semiconductors are an attractive combination, sharing similar processing technologies. Currently, perovskite-organic tandems show subpar efficiencies and are limited by the low open-circuit voltage (V-oc) of wide-gap perovskite cells(8) and losses introduced by the interconnect between the subcells(9,10). Here we demonstrate perovskite-organic tandem cells with an efficiency of 24.0 per cent (certified 23.1 per cent) and a high V-oc of 2.15 volts. Optimized charge extraction layers afford perovskite subcells with an outstanding combination of high V-oc and fill factor. The organic subcells provide a high external quantum efficiency in the near-infrared and, in contrast to paradigmatic concerns about limited photostability of non-fullerene cells(11), show an outstanding operational stability if excitons are predominantly generated on the non-fullerene acceptor, which is the case in our tandems. The subcells are connected by an ultrathin (approximately 1.5 nanometres) metal-like indium oxide layer with unprecedented low optical/electrical losses. This work sets a milestone for perovskite-organic tandems, which outperform the best p-i-n perovskite single junctions(12) and are on a par with perovskite-CIGS and all-perovskite multijunctions(13).}, language = {en} } @article{ZapataArteagaMarinaZuoetal.2022, author = {Zapata-Arteaga, Osnat and Marina, Sara and Zuo, Guangzheng and Xu, Kai and D{\"o}rling, Bernhard and Alberto P{\´e}rez, Luis and Sebasti{\´a}n Reparaz, Juan and Mart{\´i}n, Jaime and Kemerink, Martijn and Campoy-Quiles, Mariano}, title = {Design rules for polymer blends with high thermoelectric performance}, series = {Advanced energy materials}, volume = {12}, journal = {Advanced energy materials}, number = {19}, publisher = {Wiley}, address = {Weinheim}, issn = {1614-6832}, doi = {10.1002/aenm.202104076}, pages = {11}, year = {2022}, abstract = {A combinatorial study of the effect of in-mixing of various guests on the thermoelectric properties of the host workhorse polymer poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene] (PBTTT) is presented. Specifically, the composition and thickness for doped films of PBTTT blended with different polymers are varied. Some blends at guest weight fractions around 10-15\% exhibit up to a fivefold increase in power factor compared to the reference material, leading to zT values around 0.1. Spectroscopic analysis of the charge-transfer species, structural characterization using grazing-incidence wide-angle X-ray scattering, differential scanning calorimetry, Raman, and atomic force microscopy, and Monte Carlo simulations are employed to determine that the key to improved performance is for the guest to promote long-range electrical connectivity and low disorder, together with similar highest occupied molecular orbital levels for both materials in order to ensure electronic connectivity are combined.}, language = {en} } @article{NiederhoferCioniSchmidtetal.2022, author = {Niederhofer, Florian and Cioni, Maria-Rosa L. and Schmidt, Thomas and Bekki, Kenji and de Grijs, Richard and Ivanov, Valentin D. and Oliveira, Joana M. and Ripepi, Vincenzo and Subramanian, Smitha and van Loon, Jacco Th}, title = {The VMC survey - XLVI. Stellar proper motions in the centre of the Large Magellanic Cloud}, series = {Monthly notices of the Royal Astronomical Society}, volume = {512}, journal = {Monthly notices of the Royal Astronomical Society}, number = {4}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stac712}, pages = {5423 -- 5439}, year = {2022}, abstract = {We present proper motion (PM) measurements within the central region of the Large Magellanic Cloud (LMC), using near-infrared data from the VISTA survey of the Magellanic Cloud system (VMC). This work encompasses 18 VMC tiles covering a total sky area of similar to 28 deg(2). We computed absolute stellar PMs from multiepoch observations in the K-s filter over time baselines between similar to 12 and 47 months. Our final catalogue contains similar to 6322 000 likely LMC member stars with derived PMs. We employed a simple flat-rotating disc model to analyse and interpret the PM data. We found a stellar centre of rotation (alpha(0) = 79.95 degrees(+0.22)(-0.23), delta(0) = -69.31 degrees(+0.12)(-0.11)) that is in agreement with that resulting from Hubble Space Telescope data. The inferred viewing angles of the LMC disc (i = 33.5 degrees(+1.2)(-1.3), Theta = 129.8 degrees(+1.9)(-1.9)) are in good agreement with values from the literature but suggest a higher inclination of the central parts of the LMC. Our data confirm a higher rotation amplitude for the young (less than or similar to 0.5 Gyr) stars compared to the intermediate-age/old (greater than or similar to 1 Gyr) population, which can be explained by asymmetric drift. We constructed spatially resolved velocity maps of the intermediate-age/old and young populations. Intermediate-age/old stars follow elongated orbits parallel to the bar's major axis, providing first observational evidence for x(1) orbits within the LMC bar. In the innermost regions, the motions show more chaotic structures. Young stars show motions along a central filamentary bar structure.}, language = {en} } @article{PeterWenderingSchlickeiseretal.2022, author = {Peter, Lena and Wendering, D{\´e}sir{\´e}e Jacqueline and Schlickeiser, Stephan and Hoffmann, Henrike and Noster, Rebecca and Wagner, Dimitrios Laurin and Zarrinrad, Ghazaleh and M{\"u}nch, Sandra and Picht, Samira and Schulenberg, Sarah and Moradian, Hanieh and Mashreghi, Mir-Farzin and Klein, Oliver and Gossen, Manfred and Roch, Toralf and Babel, Nina and Reinke, Petra and Volk, Hans-Dieter and Amini, Leila and Schmueck-Henneresse, Michael}, title = {Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients}, series = {Molecular therapy methods and clinical development}, volume = {25}, journal = {Molecular therapy methods and clinical development}, publisher = {Cell Press}, address = {Cambridge}, issn = {2329-0501}, doi = {10.1016/j.omtm.2022.02.012}, pages = {52 -- 73}, year = {2022}, abstract = {Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that compromises their immune response to infections and vaccines. For this reason, SOT patients have a high risk of developing severe coronavirus disease 2019 (COVID-19) and an increased risk of death from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Moreover, the efficiency of immunotherapies and vaccines is reduced due to the constant immunosuppression in this patient group. Here, we propose adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, tacrolimus, for optimized performance in the immunosuppressed patient. Using a ribonucleoprotein approach of CRISPR-Cas9 technology, we have generated tacrolimus-resistant SARS-CoV-2-specific T cell products from convalescent donors and demonstrate their specificity and function through characterizations at the single-cell level, including flow cytometry, single-cell RNA (scRNA) Cellular Indexing of Transcriptomes and Epitopes (CITE), and T cell receptor (TCR) sequencing analyses. Based on the promising results, we aim for clinical validation of this approach in transplant recipients. Additionally, we propose a combinatory approach with tacrolimus, to prevent an overshooting immune response manifested as bystander T cell activation in the setting of severe COVID-19 immunopathology, and tacrolimus-resistant SARS-CoV-2-specific T cell products, allowing for efficient clearance of viral infection. Our strategy has the potential to prevent severe COVID-19 courses in SOT or autoimmunity settings and to prevent immunopathology while providing viral clearance in severe non-transplant COVID-19 cases.}, language = {en} } @article{WiemkerBunovaNeufeldetal.2022, author = {Wiemker, Veronika and Bunova, Anna and Neufeld, Maria and Gornyi, Boris and Yurasova, Elena and Konigorski, Stefan and Kalinina, Anna and Kontsevaya, Anna and Ferreira-Borges, Carina and Probst, Charlotte}, title = {Pilot study to evaluate usability and acceptability of the 'Animated Alcohol Assessment Tool' in Russian primary healthcare}, series = {Digital health}, volume = {8}, journal = {Digital health}, publisher = {Sage Publications}, address = {London}, issn = {2055-2076}, doi = {10.1177/20552076211074491}, pages = {11}, year = {2022}, abstract = {Background and aims: Accurate and user-friendly assessment tools quantifying alcohol consumption are a prerequisite to effective prevention and treatment programmes, including Screening and Brief Intervention. Digital tools offer new potential in this field. We developed the 'Animated Alcohol Assessment Tool' (AAA-Tool), a mobile app providing an interactive version of the World Health Organization's Alcohol Use Disorders Identification Test (AUDIT) that facilitates the description of individual alcohol consumption via culturally informed animation features. This pilot study evaluated the Russia-specific version of the Animated Alcohol Assessment Tool with regard to (1) its usability and acceptability in a primary healthcare setting, (2) the plausibility of its alcohol consumption assessment results and (3) the adequacy of its Russia-specific vessel and beverage selection. Methods: Convenience samples of 55 patients (47\% female) and 15 healthcare practitioners (80\% female) in 2 Russian primary healthcare facilities self-administered the Animated Alcohol Assessment Tool and rated their experience on the Mobile Application Rating Scale - User Version. Usage data was automatically collected during app usage, and additional feedback on regional content was elicited in semi-structured interviews. Results: On average, patients completed the Animated Alcohol Assessment Tool in 6:38 min (SD = 2.49, range = 3.00-17.16). User satisfaction was good, with all subscale Mobile Application Rating Scale - User Version scores averaging >3 out of 5 points. A majority of patients (53\%) and practitioners (93\%) would recommend the tool to 'many people' or 'everyone'. Assessed alcohol consumption was plausible, with a low number (14\%) of logically impossible entries. Most patients reported the Animated Alcohol Assessment Tool to reflect all vessels (78\%) and all beverages (71\%) they typically used. Conclusion: High acceptability ratings by patients and healthcare practitioners, acceptable completion time, plausible alcohol usage assessment results and perceived adequacy of region-specific content underline the Animated Alcohol Assessment Tool's potential to provide a novel approach to alcohol assessment in primary healthcare. After its validation, the Animated Alcohol Assessment Tool might contribute to reducing alcohol-related harm by facilitating Screening and Brief Intervention implementation in Russia and beyond.}, language = {en} } @article{AlvaradoGomezCohenDrakeetal.2022, author = {Alvarado-G{\´o}mez, Juli{\´a}n D. and Cohen, Ofer and Drake, Jeremy J. and Fraschetti, Federico and Poppenh{\"a}ger, Katja and Garraffo, Cecilia and Chebly, Judy and Ilin, Ekaterina and Harbach, Laura and Kochukhov, Oleg}, title = {Simulating the space weather in the AU Mic system: stellar winds and extreme coronal mass ejections}, series = {Astrophysical journal}, volume = {928}, journal = {Astrophysical journal}, number = {2}, publisher = {IOP Publishing}, address = {Bristol}, issn = {0004-637X}, doi = {10.3847/1538-4357/ac54b8}, pages = {12}, year = {2022}, abstract = {Two close-in planets have been recently found around the M-dwarf flare star AU Microscopii (AU Mic). These Neptune-sized planets (AU Mic b and c) seem to be located very close to the so-called "evaporation valley" in the exoplanet population, making this system an important target for studying atmospheric loss on exoplanets. This process, while mainly driven by high-energy stellar radiation, will be strongly mediated by the space environment surrounding the planets. Here we present an investigation of this last area, performing 3D numerical modeling of the quiescent stellar wind from AU Mic, as well as time-dependent simulations describing the evolution of a highly energetic coronal mass ejection (CME) event in this system. Observational constraints on the stellar magnetic field and properties of the eruption are incorporated in our models. We carry out qualitative and quantitative characterizations of the stellar wind, the emerging CMEs, as well as the expected steady and transient conditions along the orbit of both exoplanets. Our results predict extreme space weather for AU Mic and its planets. This includes sub-Alfvenic regions for the large majority of the exoplanet orbits, very high dynamic and magnetic pressure values in quiescence (varying within 10(2)-10(5) times the dynamic pressure experienced by Earth), and an even harsher environment during the passage of any escaping CME associated with the frequent flaring observed in AU Mic. These space weather conditions alone pose an immense challenge for the survival of exoplanetary atmospheres (if any) in this system.}, language = {en} } @article{MenzeMuellerZaehleetal.2023, author = {Menze, Inga and M{\"u}ller, Notger Germar and Z{\"a}hle, Tino and Schmicker, Marlen}, title = {Individual response to transcranial direct current stimulation as a function of working memory capacity and electrode montage}, series = {Frontiers in human neuroscience}, volume = {17}, journal = {Frontiers in human neuroscience}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2023.1134632}, pages = {14}, year = {2023}, abstract = {Introduction Attempts to improve cognitive abilities via transcranial direct current stimulation (tDCS) have led to ambiguous results, likely due to the method's susceptibility to methodological and inter-individual factors. Conventional tDCS, i.e., using an active electrode over brain areas associated with the targeted cognitive function and a supposedly passive reference, neglects stimulation effects on entire neural networks. Methods We investigated the advantage of frontoparietal network stimulation (right prefrontal anode, left posterior parietal cathode) against conventional and sham tDCS in modulating working memory (WM) capacity dependent transfer effects of a single-session distractor inhibition (DIIN) training. Since previous results did not clarify whether electrode montage drives this individual transfer, we here compared conventional to frontoparietal and sham tDCS and reanalyzed data of 124 young, healthy participants in a more robust way using linear mixed effect modeling. Results The interaction of electrode montage and WM capacity resulted in systematic differences in transfer effects. While higher performance gains were observed with increasing WM capacity in the frontoparietal stimulation group, low WM capacity individuals benefited more in the sham condition. The conventional stimulation group showed subtle performance gains independent of WM capacity. Discussion Our results confirm our previous findings of WM capacity dependent transfer effects on WM by a single-session DIIN training combined with tDCS and additionally highlight the pivotal role of the specific electrode montage. WM capacity dependent differences in frontoparietal network recruitment, especially regarding the parietal involvement, are assumed to underlie this observation.}, language = {en} } @article{WarschburgerKamrathLanzingeretal.2023, author = {Warschburger, Petra and Kamrath, Clemens and Lanzinger, Stefanie and Sengler, Claudia and Wiegand, Susanna and G{\"o}ldel, Julia Marlen and Weihrauch-Bl{\"u}her, Susann and Holl, Reinhard and Minden, Kirsten}, title = {A prospective analysis of the long-term impact of the COVID-19 pandemic on well-being and health care among children with a chronic condition and their families}, series = {BMC pediatrics}, volume = {23}, journal = {BMC pediatrics}, number = {1}, publisher = {BioMed Central}, address = {London}, issn = {1471-2431}, doi = {10.1186/s12887-023-03912-7}, pages = {15}, year = {2023}, abstract = {Background There is consistent evidence that the COVID-19 pandemic is associated with an increased psychosocial burden on children and adolescents and their parents. Relatively little is known about its particular impact on high-risk groups with chronic physical health conditions (CCs). Therefore, the primary aim of the study is to analyze the multiple impacts on health care and psychosocial well-being on these children and adolescents and their parents. Methods We will implement a two-stage approach. In the first step, parents and their underage children from three German patient registries for diabetes, obesity, and rheumatic diseases, are invited to fill out short questionnaires including questions about corona-specific stressors, the health care situation, and psychosocial well-being. In the next step, a more comprehensive, in-depth online survey is carried out in a smaller subsample. Discussion The study will provide insights into the multiple longer-term stressors during the COVID-19 pandemic in families with a child with a CC. The simultaneous consideration of medical and psycho-social endpoints will help to gain a deeper understanding of the complex interactions affecting family functioning, psychological well-being, and health care delivery.}, language = {en} } @article{MkaouerAmaraBouguezzietal.2023, author = {Mkaouer, Bessem and Amara, Samiha and Bouguezzi, Raja and Ben Abderrahmen, Abderraouf and Chaabene, Helmi}, title = {Validity of a new sport-specific endurance test in artistic gymnastics}, series = {Frontiers in sports and active living}, volume = {5}, journal = {Frontiers in sports and active living}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2023.1159807}, pages = {8}, year = {2023}, abstract = {Introduction General and particularly sport-specific testing is an integral aspect of performance optimization in artistic gymnastics. In artistic gymnastics, however, only non-specific field tests have been used to assess endurance performance (e.g., Multistage Shuttle Run Test; Cooper's Test). Methods This study aimed to examine the validity of a new sport-specific endurance test in artistic gymnastics. Fourteen elite-level gymnasts (i.e., eight males and six females) participated in this study. The newly developed artistic gymnastics-specific endurance test (AGSET) was conducted on two different occasions seven days apart to determine its reliability. To assess the concurrent validity of AGSET, participants performed the multistage shuttle run test (MSRT). Maximum oxygen uptake (VO2max) and respiratory exchange ratio (RER) were directly assessed using a portable gas analyzer system during both protocols. Additionally, the total time maintained (TTM) during the AGSET, maximum heart rate (HRmax), maximal aerobic speed (MAS), and blood lactate concentration (BLa) during the two protocols were collected. Results The main findings indicated that all variables derived from the AGSET (i.e., VO2max, MAS, HRmax, BLa, and RER) displayed very good relative (all intraclass correlation coefficients [ICC] > 0.90) and absolute (all typical errors of measurement [TEM] < 5\%) reliability. Further, results showed that the ability of the AGSET to detect small changes in VO2max, MAS, BLa, and RER was good (smallest worthwhile change [SWC0.2] > TEM), except HRmax (SWC0.2 < TEM). Additionally, results showed a nearly perfect association between the VO2max values derived from the AGSET and MSRT (r = 0.985; coefficient of determination [R-2] = 97\%) with no statistically significant differences (p>0.05). The mean (bias) +/- 95\% limits of agreement between the two protocols were 0.28 +/- 0.55 mlminkg-1. Discussion AGSET seems to present very good reliability and concurrent validity for assessing endurance performance in elite artistic gymnastics. In addition, the newly developed protocol presents a good ability to detect small changes in performance.}, language = {en} } @article{FoerstnerBoettgerMoldavskietal.2023, author = {F{\"o}rstner, Bernd Rainer and B{\"o}ttger, Sarah Jane and Moldavski, Alexander and Bajbouj, Malek and Pfennig, Andrea and Manook, Andre and Ising, Marcus and Pittig, Andre and Heinig, Ingmar and Heinz, Andreas and Mathiak, Klaus and Schulze, Thomas G. and Schneider, Frank and Kamp-Becker, Inge and Meyer-Lindenberg, Andreas and Padberg, Frank and Banaschewski, Tobias and Bauer, Michael and Rupprecht, Rainer and Wittchen, Hans-Ulrich and Rapp, Michael Armin and Tschorn, Mira}, title = {The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders}, series = {Frontiers in psychiatry}, volume = {14}, journal = {Frontiers in psychiatry}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-0640}, doi = {10.3389/fpsyt.2023.1161097}, pages = {10}, year = {2023}, abstract = {Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: \& beta; = -0.35; NVS: \& beta; = 0.39; CS: \& beta; = -0.12; SP: \& beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways.}, language = {en} } @article{TomowskiLozadaGobilardJeltschetal.2023, author = {Tomowski, Maxi and Lozada-Gobilard, Sissi Donna and Jeltsch, Florian and Tiedemann, Ralph}, title = {Recruitment and migration patterns reveal a key role for seed banks in the meta-population dynamics of an aquatic plant}, series = {Scientific reports}, volume = {13}, journal = {Scientific reports}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-023-37974-5}, pages = {16}, year = {2023}, abstract = {Progressive habitat fragmentation threatens plant species with narrow habitat requirements. While local environmental conditions define population growth rates and recruitment success at the patch level, dispersal is critical for population viability at the landscape scale. Identifying the dynamics of plant meta-populations is often confounded by the uncertainty about soil-stored population compartments. We combined a landscape-scale assessment of an amphibious plant's population structure with measurements of dispersal complexity in time to track dispersal and putative shifts in functional connectivity. Using 13 microsatellite markers, we analyzed the genetic structure of extant Oenanthe aquatica populations and their soil seed banks in a kettle hole system to uncover hidden connectivity among populations in time and space. Considerable spatial genetic structure and isolation-by-distance suggest limited gene flow between sites. Spatial isolation and patch size showed minor effects on genetic diversity. Genetic similarity found among extant populations and their seed banks suggests increased local recruitment, despite some evidence of migration and recent colonization. Results indicate stepping-stone dispersal across adjacent populations. Among permanent and ephemeral demes the resulting meta-population demography could be determined by source-sink dynamics. Overall, these spatiotemporal connectivity patterns support mainland-island dynamics in our system, highlighting the importance of persistent seed banks as enduring sources of genetic diversity.}, language = {en} } @article{MichirevKuehneLindemannetal.2023, author = {Michirev, Alexej and K{\"u}hne, Katharina and Lindemann, Oliver and Fischer, Martin H. and Raab, Markus}, title = {How to not induce SNAs}, series = {PLoS one}, volume = {18}, journal = {PLoS one}, number = {6}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0288038}, pages = {23}, year = {2023}, abstract = {People respond faster to smaller numbers in their left space and to larger numbers in their right space. Here we argue that movements in space contribute to the formation of spatial-numerical associations (SNAs). We studied the impact of continuous isometric forces along the horizontal or vertical cardinal axes on SNAs while participants performed random number production and arithmetic verification tasks. Our results suggest that such isometric directional force do not suffice to induce SNAs.}, language = {en} } @article{FehrPiccininniKurthetal.2023, author = {Fehr, Jana and Piccininni, Marco and Kurth, Tobias and Konigorski, Stefan}, title = {Assessing the transportability of clinical prediction models for cognitive impairment using causal models}, series = {BMC medical research methodology}, volume = {23}, journal = {BMC medical research methodology}, number = {1}, publisher = {BMC}, address = {London}, issn = {1471-2288}, doi = {10.1186/s12874-023-02003-6}, pages = {14}, year = {2023}, abstract = {Background Machine learning models promise to support diagnostic predictions, but may not perform well in new settings. Selecting the best model for a new setting without available data is challenging. We aimed to investigate the transportability by calibration and discrimination of prediction models for cognitive impairment in simulated external settings with different distributions of demographic and clinical characteristics. Methods We mapped and quantified relationships between variables associated with cognitive impairment using causal graphs, structural equation models, and data from the ADNI study. These estimates were then used to generate datasets and evaluate prediction models with different sets of predictors. We measured transportability to external settings under guided interventions on age, APOE \& epsilon;4, and tau-protein, using performance differences between internal and external settings measured by calibration metrics and area under the receiver operating curve (AUC). Results Calibration differences indicated that models predicting with causes of the outcome were more transportable than those predicting with consequences. AUC differences indicated inconsistent trends of transportability between the different external settings. Models predicting with consequences tended to show higher AUC in the external settings compared to internal settings, while models predicting with parents or all variables showed similar AUC. Conclusions We demonstrated with a practical prediction task example that predicting with causes of the outcome results in better transportability compared to anti-causal predictions when considering calibration differences. We conclude that calibration performance is crucial when assessing model transportability to external settings.}, language = {en} } @article{TeichFuehnerBaehretal.2023, author = {Teich, Paula and F{\"u}hner, Thea Heidi and Baehr, Florian and Puta, Christian and Granacher, Urs and Kliegl, Reinhold}, title = {Covid pandemic effects on the physical fitness of primary school children}, series = {Sports Medicine - Open}, volume = {9}, journal = {Sports Medicine - Open}, number = {1}, publisher = {Springer}, address = {New York}, issn = {2198-9761}, doi = {10.1186/s40798-023-00624-1}, pages = {19}, year = {2023}, abstract = {BackgroundIn spring of 2020, the Sars-CoV-2 incidence rate increased rapidly in Germany and around the world. Throughout the next 2 years, schools were temporarily closed and social distancing measures were put in place to slow the spread of the Covid-19 virus. Did these social restrictions and temporary school lockdowns affect children's physical fitness? The EMOTIKON project annually tests the physical fitness of all third-graders in the Federal State of Brandenburg, Germany. The tests assess cardiorespiratory endurance (6-min-run test), coordination (star-run test), speed (20-m sprint test), lower (powerLOW, standing long jump test), and upper (powerUP, ball-push test) limbs muscle power, and static balance (one-legged stance test with eyes closed). A total of 125,893 children were tested in the falls from 2016 to 2022. Primary analyses focused on 98,510 keyage third-graders (i.e., school enrollment according to the legal key date, aged 8 to 9 years) from 515 schools. Secondary analyses included 27,383 older-than-keyage third-graders (i.e., OTK, delayed school enrollment or repetition of a grade, aged 9 to 10 years), who have been shown to exhibit lower physical fitness than expected for their age. Linear mixed models fitted pre-pandemic quadratic secular trends, and took into account differences between children and schools.ResultsThird-graders exhibited lower cardiorespiratory endurance, coordination, speed and powerUP in the Covid pandemic cohorts (2020-2022) compared to the pre-pandemic cohorts (2016-2019). Children's powerLOW and static balance were higher in the pandemic cohorts compared to the pre-pandemic cohorts. From 2020 to 2021, coordination, powerLOW and powerUP further declined. Evidence for some post-pandemic physical fitness catch-up was restricted to powerUP. Cohen's |ds| for comparisons of the pandemic cohorts 2020-2022 with pre-pandemic cohorts 2016-2019 ranged from 0.02 for powerLOW to 0.15 for coordination. Within the pandemic cohorts, keyage children exhibited developmental losses ranging from approximately 1 month for speed to 5 months for cardiorespiratory endurance. For powerLOW and static balance, the positive pandemic effects translate to developmental gains of 1 and 7 months, respectively. Pre-pandemic secular trends may account for some of the observed differences between pandemic and pre-pandemic cohorts, especially in powerLOW, powerUP and static balance. The pandemic further increased developmental delays of OTK children in cardiorespiratory endurance, powerUP and balance.ConclusionsThe Covid-19 pandemic was associated with declines in several physical fitness components in German third-graders. Pandemic effects are still visible in 2022. Health-related interventions should specifically target those physical fitness components that were negatively affected by the pandemic (cardiorespiratory endurance, coordination, speed).}, language = {en} } @article{ArendZimmerXuetal.2023, author = {Arend, Marius and Zimmer, David and Xu, Rudan and Sommer, Frederik and M{\"u}hlhaus, Timo and Nikoloski, Zoran}, title = {Proteomics and constraint-based modelling reveal enzyme kinetic properties of Chlamydomonas reinhardtii on a genome scale}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-40498-1}, pages = {9}, year = {2023}, abstract = {Metabolic engineering of microalgae offers a promising solution for sustainable biofuel production, and rational design of engineering strategies can be improved by employing metabolic models that integrate enzyme turnover numbers. However, the coverage of turnover numbers for Chlamydomonas reinhardtii, a model eukaryotic microalga accessible to metabolic engineering, is 17-fold smaller compared to the heterotrophic cell factory Saccharomyces cerevisiae. Here we generate quantitative protein abundance data of Chlamydomonas covering 2337 to 3708 proteins in various growth conditions to estimate in vivo maximum apparent turnover numbers. Using constrained-based modeling we provide proxies for in vivo turnover numbers of 568 reactions, representing a 10-fold increase over the in vitro data for Chlamydomonas. Integration of the in vivo estimates instead of in vitro values in a metabolic model of Chlamydomonas improved the accuracy of enzyme usage predictions. Our results help in extending the knowledge on uncharacterized enzymes and improve biotechnological applications of Chlamydomonas.}, language = {en} } @article{FerreiraDammhahnEccard2023, author = {Ferreira, Clara Mendes and Dammhahn, Melanie and Eccard, Jana}, title = {So many choices, so little time}, series = {Ecology and evolution}, volume = {13}, journal = {Ecology and evolution}, number = {7}, publisher = {Wiley}, address = {Hoboken}, issn = {2045-7758}, doi = {10.1002/ece3.10330}, pages = {15}, year = {2023}, abstract = {Spatial and temporal variation in perceived predation risk is an important determinant of movement and foraging activity of animals. Foraging in this landscape of fear, individuals need to decide where and when to move, and what resources to choose. Foraging theory predicts the outcome of these decisions based on energetic trade-offs, but complex interactions between perceived predation risk and preferences of foragers for certain functional traits of their resources are rarely considered. Here, we studied the interactive effects of perceived predation risk on food trait preferences and foraging behavior in bank voles (Myodes glareolus) in experimental landscapes. Individuals (n = 19) were subjected for periods of 24 h to two extreme, risk-uniform landscapes (either risky or safe), containing 25 discrete food patches, filled with seeds of four plant species in even amounts. Seeds varied in functional traits: size, nutrients, and shape. We evaluated whether and how risk modifies forager preference for functional traits. We also investigated whether perceived risk and distance from shelter affected giving-up density (GUD), time in patches, and number of patch visits. In safe landscapes, individuals increased time spent in patches, lowered GUD and visited distant patches more often compared to risky landscapes. Individuals preferred bigger seeds independent of risk, but in the safe treatment they preferred fat-rich over carb-rich seeds. Thus, higher densities of resource levels remained in risky landscapes, while in safe landscapes resource density was lower and less diverse due to selective foraging. Our results suggest that the interaction of perceived risk and dietary preference adds an additional layer to the cascading effects of a landscape of fear which affects biodiversity at resource level.}, language = {en} } @article{GarrelsKhodabakhshRenardetal.2023, author = {Garrels, Tim and Khodabakhsh, Athar and Renard, Bernhard Y. and Baum, Katharina}, title = {LazyFox: fast and parallelized overlapping community detection in large graphs}, series = {PEERJ Computer Science}, volume = {9}, journal = {PEERJ Computer Science}, publisher = {PeerJ Inc.}, address = {London}, issn = {2376-5992}, doi = {10.7717/peerj-cs.1291}, pages = {30}, year = {2023}, abstract = {The detection of communities in graph datasets provides insight about a graph's underlying structure and is an important tool for various domains such as social sciences, marketing, traffic forecast, and drug discovery. While most existing algorithms provide fast approaches for community detection, their results usually contain strictly separated communities. However, most datasets would semantically allow for or even require overlapping communities that can only be determined at much higher computational cost. We build on an efficient algorithm, FOX, that detects such overlapping communities. FOX measures the closeness of a node to a community by approximating the count of triangles which that node forms with that community. We propose LAZYFOX, a multi-threaded adaptation of the FOX algorithm, which provides even faster detection without an impact on community quality. This allows for the analyses of significantly larger and more complex datasets. LAZYFOX enables overlapping community detection on complex graph datasets with millions of nodes and billions of edges in days instead of weeks. As part of this work, LAZYFOX's implementation was published and is available as a tool under an MIT licence at https://github.com/TimGarrels/LazyFox.}, language = {en} } @article{PetrichAjiDunsingetal.2023, author = {Petrich, Annett and Aji, Amit Koikkarah and Dunsing, Valentin and Chiantia, Salvatore}, title = {Benchmarking of novel green fluorescent proteins for the quantification of protein oligomerization in living cells}, series = {PLoS one}, volume = {18}, journal = {PLoS one}, number = {8}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0285486}, pages = {13}, year = {2023}, abstract = {Protein-protein-interactions play an important role in many cellular functions. Quantitative non-invasive techniques are applied in living cells to evaluate such interactions, thereby providing a broader understanding of complex biological processes. Fluorescence fluctuation spectroscopy describes a group of quantitative microscopy approaches for the characterization of molecular interactions at single cell resolution. Through the obtained molecular brightness, it is possible to determine the oligomeric state of proteins. This is usually achieved by fusing fluorescent proteins (FPs) to the protein of interest. Recently, the number of novel green FPs has increased, with consequent improvements to the quality of fluctuation-based measurements. The photophysical behavior of FPs is influenced by multiple factors (including photobleaching, protonation-induced "blinking" and long-lived dark states). Assessing these factors is critical for selecting the appropriate fluorescent tag for live cell imaging applications. In this work, we focus on novel green FPs that are extensively used in live cell imaging. A systematic performance comparison of several green FPs in living cells under different pH conditions using Number \& Brightness (N \& B) analysis and scanning fluorescence correlation spectroscopy was performed. Our results show that the new FP Gamillus exhibits higher brightness at the cost of lower photostability and fluorescence probability (pf), especially at lower pH. mGreenLantern, on the other hand, thanks to a very high pf, is best suited for multimerization quantification at neutral pH. At lower pH, mEGFP remains apparently the best choice for multimerization investigation. These guidelines provide the information needed to plan quantitative fluorescence microscopy involving these FPs, both for general imaging or for protein-protein-interactions quantification via fluorescence fluctuation-based methods.}, language = {en} } @article{HovhannisyanNematiHenkeletal.2023, author = {Hovhannisyan, Karen V. and Nemati, Somayyeh and Henkel, Carsten and Anders, Janet}, title = {Long-time equilibration can determine transient thermality}, series = {PRX Quantum}, volume = {4}, journal = {PRX Quantum}, number = {3}, publisher = {American Physical Society}, address = {College Park}, issn = {2691-3399}, doi = {10.1103/PRXQuantum.4.030321}, pages = {23}, year = {2023}, abstract = {When two initially thermal many-body systems start to interact strongly, their transient states quickly become non-Gibbsian, even if the systems eventually equilibrate. To see beyond this apparent lack of structure during the transient regime, we use a refined notion of thermality, which we call g-local. A system is g-locally thermal if the states of all its small subsystems are marginals of global thermal states. We numerically demonstrate for two harmonic lattices that whenever the total system equilibrates in the long run, each lattice remains g-locally thermal at all times, including the transient regime. This is true even when the lattices have long-range interactions within them. In all cases, we find that the equilibrium is described by the generalized Gibbs ensemble, with three-dimensional lattices requiring special treatment due to their extended set of conserved charges. We compare our findings with the well-known two-temperature model. While its standard form is not valid beyond weak coupling, we show that at strong coupling it can be partially salvaged by adopting the concept of a g-local temperature.}, language = {en} } @article{KappattanavarHeckerMoontahaetal.2023, author = {Kappattanavar, Arpita Mallikarjuna and Hecker, Pascal and Moontaha, Sidratul and Steckhan, Nico and Arnrich, Bert}, title = {Food choices after cognitive load}, series = {Sensors}, volume = {23}, journal = {Sensors}, number = {14}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s23146597}, pages = {22}, year = {2023}, abstract = {Psychology and nutritional science research has highlighted the impact of negative emotions and cognitive load on calorie consumption behaviour using subjective questionnaires. Isolated studies in other domains objectively assess cognitive load without considering its effects on eating behaviour. This study aims to explore the potential for developing an integrated eating behaviour assistant system that incorporates cognitive load factors. Two experimental sessions were conducted using custom-developed experimentation software to induce different stimuli. During these sessions, we collected 30 h of physiological, food consumption, and affective states questionnaires data to automatically detect cognitive load and analyse its effect on food choice. Utilising grid search optimisation and leave-one-subject-out cross-validation, a support vector machine model achieved a mean classification accuracy of 85.12\% for the two cognitive load tasks using eight relevant features. Statistical analysis was performed on calorie consumption and questionnaire data. Furthermore, 75\% of the subjects with higher negative affect significantly increased consumption of specific foods after high-cognitive-load tasks. These findings offer insights into the intricate relationship between cognitive load, affective states, and food choice, paving the way for an eating behaviour assistant system to manage food choices during cognitive load. Future research should enhance system capabilities and explore real-world applications.}, language = {en} } @article{MeyerPohlPetrovetal.2023, author = {Meyer, Dominique M.-A. and Pohl, Martin and Petrov, M. and Egberts, Kathrin}, title = {Mixing of materials in magnetized core-collapse supernova remnants}, series = {Monthly notices of the Royal Astronomical Society}, volume = {521}, journal = {Monthly notices of the Royal Astronomical Society}, number = {4}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stad906}, pages = {5354 -- 5371}, year = {2023}, abstract = {Core-collapse supernova remnants are structures of the interstellar medium (ISM) left behind the explosive death of most massive stars ( ?40 M-?). Since they result in the expansion of the supernova shock wave into the gaseous environment shaped by the star's wind history, their morphology constitutes an insight into the past evolution of their progenitor star. Particularly, fast-mo ving massiv e stars can produce asymmetric core-collapse superno va remnants. We inv estigate the mixing of materials in core-collapse supernova remnants generated by a moving massive 35 M-? star, in a magnetized ISM. Stellar rotation and the wind magnetic field are time-dependently included into the models which follow the entire evolution of the stellar surroundings from the zero-age main-sequence to 80 kyr after the supernova explosion. It is found that very little main-sequence material is present in remnants from moving stars, that the Wolf-Rayet wind mixes very efficiently within the 10 kyr after the explosion, while the red supergiant material is still unmixed by 30 per cent within 50 kyr after the supernova. Our results indicate that the faster the stellar motion, the more complex the internal organization of the supernova remnant and the more ef fecti ve the mixing of ejecta therein. In contrast, the mixing of stellar wind material is only weakly affected by progenitor motion, if at all.}, language = {en} } @article{ErlerRiebeBeitzetal.2023, author = {Erler, Alexander and Riebe, Daniel and Beitz, Toralf and L{\"o}hmannsr{\"o}ben, Hans-Gerd and Leenen, Mathias and P{\"a}tzold, Stefan and Ostermann, Markus and W{\´o}jcik, Michał}, title = {Mobile laser-induced breakdown spectroscopy for future application in precision agriculture}, series = {Sensors}, volume = {23}, journal = {Sensors}, number = {16}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s23167178}, pages = {17}, year = {2023}, abstract = {In precision agriculture, the estimation of soil parameters via sensors and the creation of nutrient maps are a prerequisite for farmers to take targeted measures such as spatially resolved fertilization. In this work, 68 soil samples uniformly distributed over a field near Bonn are investigated using laser-induced breakdown spectroscopy (LIBS). These investigations include the determination of the total contents of macro- and micronutrients as well as further soil parameters such as soil pH, soil organic matter (SOM) content, and soil texture. The applied LIBS instruments are a handheld and a platform spectrometer, which potentially allows for the single-point measurement and scanning of whole fields, respectively. Their results are compared with a high-resolution lab spectrometer. The prediction of soil parameters was based on multivariate methods. Different feature selection methods and regression methods like PLS, PCR, SVM, Lasso, and Gaussian processes were tested and compared. While good predictions were obtained for Ca, Mg, P, Mn, Cu, and silt content, excellent predictions were obtained for K, Fe, and clay content. The comparison of the three different spectrometers showed that although the lab spectrometer gives the best results, measurements with both field spectrometers also yield good results. This allows for a method transfer to the in-field measurements.}, language = {en} } @article{MatternvonReppertZeuschneretal.2023, author = {Mattern, Maximilian and von Reppert, Alexander and Zeuschner, Steffen Peer and Herzog, Marc and Pudell, Jan-Etienne and Bargheer, Matias}, title = {Concepts and use cases for picosecond ultrasonics with x-rays}, series = {Photoacoustics}, volume = {31}, journal = {Photoacoustics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2213-5979}, doi = {10.1016/j.pacs.2023.100503}, pages = {22}, year = {2023}, abstract = {This review discusses picosecond ultrasonics experiments using ultrashort hard x-ray probe pulses to extract the transient strain response of laser-excited nanoscopic structures from Bragg-peak shifts. This method provides direct, layer-specific, and quantitative information on the picosecond strain response for structures down to few-nm thickness. We model the transient strain using the elastic wave equation and express the driving stress using Gruneisen parameters stating that the laser-induced stress is proportional to energy density changes in the microscopic subsystems of the solid, i.e., electrons, phonons and spins. The laser-driven strain response can thus serve as an ultrafast proxy for local energy-density and temperature changes, but we emphasize the importance of the nanoscale morphology for an accurate interpretation due to the Poisson effect. The presented experimental use cases encompass ultrathin and opaque metal-heterostructures, continuous and granular nanolayers as well as negative thermal expansion materials, that each pose a challenge to established all-optical techniques.}, language = {en} }