@misc{RodriguezSillkeSchumannLissneretal.2020,
  author    = {Rodr{\´i}guez Sillke, Yasmina and Schumann, Michael and Lissner, Donata and Branchi, Frederica and Glauben, Rainer and Siegmund, Britta},
  title     = {Small intestinal inflammation but not colitis drives pro-inflammatory nutritional antigen-specific T-cell response},
  series = {Journal of Crohn's and Colitis},
  volume    = {14},
  journal   = {Journal of Crohn's and Colitis},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {1873-9946},
  doi       = {10.1093/ecco-jcc/jjz203.172},
  pages     = {S154 -- S155},
  year      = {2020},
  abstract  = {Background: Inflammatory bowel disease (IBD) represents a dysregulation of the mucosal immune system. The pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) is linked to the loss of intestinal tolerance and barrier function. The healthy mucosal immune system has previously been shown to be inert against food antigens. Since the small intestine is the main contact surface for antigens and therefore the immunological response, the present study served to analyse food-antigen-specific T cells in the peripheral blood of IBD patients. Methods: Peripheral blood mononuclear cells of CD, with an affected small intestine, and UC (colitis) patients, either active or in remission, were stimulated with the following food antigens: gluten, soybean, peanut and ovalbumin. Healthy controls and celiac disease patients were included as controls. Antigen-activated CD4+ T cells in the peripheral blood were analysed by a magnetic enrichment of CD154+ effector T cells and a cytometric antigen-reactive T-cell analysis ('ARTE' technology) followed by characterisation of the ef- fector response. Results: The effector T-cell response of antigen-specific T cells were compared between CD with small intestinal inflammation and UC where inflammation was restricted to the colon. Among all tested food antigens, the highest frequency of antigen-specific T cells (CD4+CD154+) was found for gluten. Celiac disease patients were included as control, since gluten has been identified as the disease- causing antigen. The highest frequency of gluten antigen-specific T cells was revealed in active CD when compared with UC, celiac disease on a gluten-free diet (GFD) and healthy controls. Ovalbuminspecific T cells were almost undetectable, whereas the reaction to soybean and peanut was slightly higher. But again, the strong- est reaction was observed in CD with small intestinal involvement compared with UC. Remarkably, in celiac disease on a GFD only antigen-specific cells for gluten were detected. These gluten-specific T cells were characterised by up-regulation of the pro-inflammatory cytokines IFN-γ, IL-17A and TNF-α. IFN-g was exclusively elevated in CD patients with active disease. Gluten-specific T-cells expressing IL-17A were increased in all IBD patients. Furthermore, T cells of CD patients, independent of disease activity, revealed a high expression of the pro-inflammatory cytokine TNF-α. Conclusion: The 'ARTE'-technique allows to analyse and quantify food antigen specific T cells in the peripheral blood of IBD patients indicating a potential therapeutic insight. These data provide evidence that small intestinal inflammation in CD is key for the development of a systemic pro-inflammatory effector T-cell response driven by food antigens.},
  language  = {en}
}
@misc{DoegeSchumacherBalzusetal.2017,
  author    = {D{\"o}ge, Nadine and Schumacher, Fabian and Balzus, Benjamin and Colombo, Miriam and Hadam, Sabrina and Rancan, Fiorenza and Blume-Peytavi, Ulrike and Kleuser, Burkhard and Bodmeier, Roland and Vogt, Annika},
  title     = {Particle- based formulations and controlled skin barrier disruption have a signifi cant impact on the delivery and penetration kinetics of dexamethasone as assessed in an ex vivo microdialysis},
  series = {Journal der Deutschen Dermatologischen Gesellschaft},
  volume    = {15},
  journal   = {Journal der Deutschen Dermatologischen Gesellschaft},
  publisher = {Wiley},
  address   = {Berlin},
  issn      = {1610-0379},
  pages     = {182 -- 182},
  year      = {2017},
  abstract  = {Preclinical assessment of penetration not only in intact, but also in barrier-disrupted skin is important to explore the surplus value of novel drug delivery systems, which can be specifically designed for diseased skin. Here, we characterized physical and chemical barrier disruption protocols for short-term ex vivo skin cultures with regard to structural integrity, physiological and biological parameters. Further, we compared the penetration of dexamethasone (Dex) in different nanoparticle-based formulations in stratum corneum, epidermis and dermis extracts of intact vs. barrier-disrupted skin as well as by dermal microdialysis at 6, 12 and 24 hours after topical application. Dex was quantified by liquid-chromatography - tandem-mass spectrometry (LC-MS/MS). Simultaneously, we investigated the Dex efficacy by interleukin (IL) analysis. Tape-stripping (TS) and 4 hours sodium lauryl sulfate 5 \% (SLS) exposure were identified as highly effective barrier disruption methods assessed by reproducible transepidermal water loss (TEWL) changes and IL-6/8 increase which was more pronounced in SLS-treated skin. The barrier state has also a significant impact on the Dex penetration kinetics: for all formulations, TS highly increased dermal Dex concentration despite the fact that nanocrystals quickly and effectively penetrated both, intact and barrier-disrupted skin reaching significantly higher dermal Dex concentration after 6 hours compared to Dex cream. The surplus value of encapsulation in ethyl cellulose nanocarriers could mostly be observed when applied on intact skin, in general showing a delayed Dex penetration. Estimation of cytokines was limited due to the trauma caused by probe insertion. In summary, ex vivo human skin is a highly interesting short-term preclinical model for the analysis of penetration and efficacy of novel drug delivery systems.},
  language  = {en}
}
@misc{HalibasicFuerstHeidenetal.2017,
  author    = {Halibasic, Emina and Fuerst, Elisabeth and Heiden, Denis and Japtok, Lukasz and Diesner, Susanne C. and Hillebrand, P. and Trauner, Michael and Kleuser, Burkhard and Kazemi-Shirazi, Lili and Untersmayr, Eva},
  title     = {Significantly reduced plasma levels of the bioactive sphingolipid S1P in lung transplanted cystic fibrosis patients are associated with gastrointestinal symptoms},
  series = {Allergy},
  volume    = {72},
  journal   = {Allergy},
  number    = {S103},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0105-4538},
  pages     = {195 -- 195},
  year      = {2017},
  language  = {en}
}
@misc{ChenBornhorstNeelyetal.2018,
  author    = {Chen, Pan and Bornhorst, Julia and Neely, M. Diana and Avila, Daiana Silva},
  title     = {Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress},
  series = {Oxidative Medicine and Cellular Longevity},
  journal   = {Oxidative Medicine and Cellular Longevity},
  publisher = {Hindawi},
  address   = {London},
  issn      = {1942-0900},
  doi       = {10.1155/2018/7612172},
  pages     = {3},
  year      = {2018},
  language  = {en}
}
@misc{Steinberg2018,
  author    = {Steinberg, Pablo},
  title     = {Only one Component of a holistic Nutrition Policy},
  series = {Fleischwirtschaft},
  volume    = {98},
  journal   = {Fleischwirtschaft},
  number    = {11},
  publisher = {Deutscher Fachverlag GmbH},
  address   = {Frankfurt am Main},
  issn      = {0015-363X},
  pages     = {8 -- 9},
  year      = {2018},
  language  = {de}
}
@misc{HocherZeng2018,
  author    = {Hocher, Berthold and Zeng, Shufei},
  title     = {Need for better PTH assays for clinical research and patient treatment},
  series = {Clinical chemistry and laboratory medicine : journal of the Forum of the European Societies of Clinical Chemistry - the European Branch of the International Federation of Clinical Chemistry and Laboratory Medicine},
  volume    = {56},
  journal   = {Clinical chemistry and laboratory medicine : journal of the Forum of the European Societies of Clinical Chemistry - the European Branch of the International Federation of Clinical Chemistry and Laboratory Medicine},
  number    = {2},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {1434-6621},
  doi       = {10.1515/cclm-2017-0617},
  pages     = {183 -- 185},
  year      = {2018},
  language  = {en}
}
@misc{PischonRadbruchOstrowskietal.2017,
  author    = {Pischon, Hannah and Radbruch, Moritz and Ostrowski, Anja and Schumacher, Fabian and Hoenzke, Stefan and Kleuser, Burkhard and Hedtrich, Sarah and Fluhr, Joachim W. and Gruber, Achim D. and Mundhenk, Lars},
  title     = {How Effective Is Tacrolimus in the Imiquimod},
  series = {The journal of investigative dermatology},
  volume    = {138},
  journal   = {The journal of investigative dermatology},
  number    = {2},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {0022-202X},
  doi       = {10.1016/j.jid.2017.09.019},
  pages     = {455 -- 458},
  year      = {2017},
  language  = {en}
}
@misc{HonnenWellenbergWeidesetal.2018,
  author    = {Honnen, S. and Wellenberg, Anna and Weides, L. and Bornhorst, Julia and Crone, B. and Karst, U. and Fritz, G.},
  title     = {Identification of potent drug candidates for the prevention of cisplatin-induced neurotoxicity in the model organism C. elegans},
  series = {Naunyn-Schmiedeberg's archives of pharmacology},
  volume    = {391},
  journal   = {Naunyn-Schmiedeberg's archives of pharmacology},
  publisher = {Springer},
  address   = {New York},
  issn      = {0028-1298},
  doi       = {10.1007/s00210-018-1477-5},
  pages     = {S4 -- S4},
  year      = {2018},
  language  = {en}
}
@misc{ReichetzederHocher2017,
  author    = {Reichetzeder, Christoph and Hocher, Berthold},
  title     = {DPP4 inhibition prevents AKI},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  publisher = {Impact Journals LLC},
  address   = {Orchard Park},
  issn      = {1949-2553},
  doi       = {10.18632/oncotarget.20212},
  pages     = {64655 -- 64656},
  year      = {2017},
  language  = {en}
}
@misc{HocherZeng2018,
  author    = {Hocher, Berthold and Zeng, Shufei},
  title     = {Clear the fog around parathyroid hormone assays},
  series = {Clinical journal of the American Society of Nephrology},
  volume    = {13},
  journal   = {Clinical journal of the American Society of Nephrology},
  number    = {4},
  publisher = {American Society of Nephrology},
  address   = {Washington},
  issn      = {1555-9041},
  doi       = {10.2215/CJN.01730218},
  pages     = {524 -- 526},
  year      = {2018},
  language  = {en}
}
@misc{FernandoDrescherDeubeletal.2018,
  author    = {Fernando, Raquel and Drescher, Cathleen and Deubel, Stefanie and Grune, Tilman and Castro, Jose Pedro},
  title     = {Distinct proteasomal activity for fast and slow twitch skeletal muscle during aging},
  series = {Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research},
  volume    = {120},
  journal   = {Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {0891-5849},
  doi       = {10.1016/j.freeradbiomed.2018.04.393},
  pages     = {S119 -- S119},
  year      = {2018},
  abstract  = {Skeletal muscle alterations during aging lead to dysfunctional metabolism, correlating with frailty and early mortality. The loss of proteostasis is a hallmark of aging. Whether proteostasis loss plays a role in muscle aging remains elusive. To address this question we collected muscles, Soleus (SOL, type I) and Extensor digitorum longus (EDL, type II), from young (4 months) and old (25 months) C57BL/6 mice and evaluated the proteasomal system. Initial work showed decreased 26 S activity in old SOL. EDL displayed lower proteasomal activity in both ages compared to any of the SOL ages. Moreover, in order to understand if during aging there is the so-called "fiber switch from fast-to-slow", we performed western blots against sMHC and fMHC (slow and fast myosin heavy chain, respectively). Preliminary results suggest that young SOL is composed by slow twitch fibers but also contains fast twitch fibers, while young EDL seems to be mostly composed by fast twitch fibers that level down during aging, suggesting the switch. As a conclusion, EDL seems to have less proteasomal activity, however, if this is a contributor or a consequence to the muscle fiber switch during aging still needs further investigation.},
  language  = {en}
}
@misc{SchulzeMartinezGonzalezFungetal.2018,
  author    = {Schulze, Matthias Bernd and Martinez-Gonzalez, Miguel A. and Fung, Teresa T. and Lichtenstein, Alice H. and Forouhi, Nita G.},
  title     = {Food based dietary patterns and chronic disease prevention},
  series = {BMJ-British medical journal},
  volume    = {361},
  journal   = {BMJ-British medical journal},
  publisher = {BMJ Publishing Group},
  address   = {London},
  issn      = {1756-1833},
  doi       = {10.1136/bmj.k2396},
  pages     = {6},
  year      = {2018},
  abstract  = {Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research directions.},
  language  = {en}
}
@misc{JamnokSanchaisuriyaYamsrietal.2018,
  author    = {Jamnok, Jutatip and Sanchaisuriya, Kanokwan and Yamsri, Supawadee and Fucharoen, Goonnapa and Fucharoen, Supan and Schweigert, Florian J. and Sanchaisuriya, Pattara},
  title     = {Application of a new portable nephelometer for screening thalassemia in countries with limited resources},
  series = {International Journal of Laboratory Hematology},
  volume    = {40},
  journal   = {International Journal of Laboratory Hematology},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1751-5521},
  pages     = {62 -- 62},
  year      = {2018},
  language  = {en}
}
@misc{JamnokSanchaisuriyaYamsrietal.2018,
  author    = {Jamnok, Jutatip and Sanchaisuriya, Kanokwan and Yamsri, Supawadee and Fucharoen, Goonnapa and Fucharoen, Supan and Schweigert, Florian J. and Sanchaisuriya, Pattara},
  title     = {Application of a new portable nephelometer for screening thalassemia in countries with limited resources},
  series = {International journal of laboratory hematology},
  volume    = {40},
  journal   = {International journal of laboratory hematology},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1751-5521},
  pages     = {62 -- 62},
  year      = {2018},
  abstract  = {One-tube osmotic fragility (OF) test is a rapid test used widely for screening thalassemia in countries with limited resources. The test has important limitation in that its accuracy relies on observers' experience. The iCheck Turbidity is a prototype of portable nephelometer developed by BioAnalyt (Bioanalyt GmbH, Germany). In this study, we assessed the applicability of the iCheck Turbidity, for checking turbidity of the OF-test},
  language  = {en}
}
@misc{Kleuser2018,
  author    = {Kleuser, Burkhard},
  title     = {The enigma of sphingolipids in health and disease},
  series = {International journal of molecular sciences},
  volume    = {19},
  journal   = {International journal of molecular sciences},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms19103126},
  pages     = {3},
  year      = {2018},
  language  = {en}
}
@misc{Henze2018,
  author    = {Henze, Andrea},
  title     = {Proteinoxidation als Indikator des Alterungsph{\"a}notyps und Target einer individualisierten Ern{\"a}hrungsintervention (ProAID)},
  series = {Ern{\"a}hrungs-Umschau : Forschung \& Praxis},
  volume    = {65},
  journal   = {Ern{\"a}hrungs-Umschau : Forschung \& Praxis},
  number    = {10},
  publisher = {Umschau-Zeitschriftenverl.},
  address   = {Frankfurt, Main},
  issn      = {0174-0008},
  pages     = {M566 -- M567},
  year      = {2018},
  abstract  = {Oxidative posttranslationale Modifikationen endogener Proteine werden v. a. durch reaktive Sauerstoff- und Stickstoffspezies (engl:. Reactive Oxygen Species, ROS, reactive nitrogen species, RNS) hervorgerufen und k{\"o}nnen sowohl reversibel (z. B. Disulfidbindungen) als auch irreversibel (z. B. Proteincarbonyle) erfolgen [1-3]. Lange wurde angenommen, dass oxidative posttranslationale Proteinmodifikationen (oxPTPM) nur von untergeordneter Bedeutung f{\"u}r den Metabolismus sind. Tats{\"a}chlich handelt es sich jedoch um einen physiologischen Prozess, der {\"u}ber die Modulation der Proteinstruktur auch die Proteinfunktion (z. B. Enzymaktivit{\"a}t, Stabilit{\"a}t) und somit zahlreiche Stoffwechselwege wie den Energiestoffwechsel, die Immunfunktion, die vaskul{\"a}re Funktion sowie Apoptose und Genexpression beeinflussen kann. Die Bildung von oxPTPM ist dabei hochreguliert und h{\"a}ngt u. a. von der Proteinstruktur, der Verf{\"u}gbarkeit von ROS und RNS sowie dem lokalen Mikromilieu der Zelle ab [2, 4].},
  language  = {de}
}
@misc{UhligGehreKammereretal.2018,
  author    = {Uhlig, Katja and Gehre, Christian P. and Kammerer, Sarah and K{\"u}pper, Jan-Heiner and Coleman, Charles Dominic and P{\"u}schel, Gerhard Paul and Duschl, Claus},
  title     = {Real-time monitoring of oxygen consumption of hepatocytes in a microbioreactor},
  series = {Toxicology letters},
  volume    = {295},
  journal   = {Toxicology letters},
  publisher = {Elsevier},
  address   = {Clare},
  issn      = {0378-4274},
  doi       = {10.1016/j.toxlet.2018.06.652},
  pages     = {S115 -- S115},
  year      = {2018},
  language  = {en}
}
@misc{PonceSchererBoekstegersetal.2019,
  author    = {Ponce, Carol Barahona and Scherer, Dominique and Boekstegers, Felix and Garate-Calderon, Valentina and Jenab, Mazda and Aleksandrova, Krasimira and Katzke, Verena and Weiderpass, Elisabete and Bonet, Catalina and Moradi, Tahereh and Fischer, Krista and Bossers, Willem and Brenner, Hermann and Sch{\"o}ttker, Ben and Holleczek, Bernd and Hveem, Kristian and Eklund, Niina and Voelker, Uwe and Waldenberger, Melanie and Bermejo, Justo Lorenzo},
  title     = {Arsenic and gallbladder cancer risk},
  series = {International journal of cancer},
  volume    = {146},
  journal   = {International journal of cancer},
  number    = {9},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0020-7136},
  doi       = {10.1002/ijc.32837},
  pages     = {2648 -- 2650},
  year      = {2019},
  language  = {en}
}
@misc{WellenbergWeidesBornhorstetal.2019,
  author    = {Wellenberg, Anna and Weides, L. and Bornhorst, Julia and Crone, Barbara and Karst, U. and Fritz, G. and Honnen, S.},
  title     = {Molecular and electrophysiological analysis of platinum-induced neurotoxicity using the model organism C. elegans},
  series = {Naunyn-Schmiedeberg's archives of pharmacology},
  volume    = {392},
  journal   = {Naunyn-Schmiedeberg's archives of pharmacology},
  publisher = {Springer},
  address   = {New York},
  issn      = {0028-1298},
  doi       = {10.1007/s00210-019-01621-6},
  pages     = {S63 -- S63},
  year      = {2019},
  language  = {en}
}
@misc{Kleuser2017,
  author    = {Kleuser, Burkhard},
  title     = {Medikamentennebenwirkungen auf Haut und Schleimhaut - allergische oder pharmakologisch erkl{\"a}rbare Reaktionen},
  series = {Allergologie},
  volume    = {40},
  journal   = {Allergologie},
  number    = {10},
  publisher = {Dustri-Verlag},
  address   = {Deisenhofen-M{\"u}nchen},
  issn      = {0344-5062},
  pages     = {420 -- 421},
  year      = {2017},
  language  = {de}
}