@article{MatthiasRisslingPieperetal.2020,
  author    = {Matthias, Katja and Rissling, Olesja and Pieper, Dawid Aleksander and Morche, Johannes and Nocon, Marc and Jacobs, Anja and Wegewitz, Uta Elke and Schirm, Jaqueline and Lorenz, Robert C.},
  title     = {The methodological quality of systematic reviews on the treatment of adult major depression needs improvement according to AMSTAR 2},
  series = {Heliyon},
  volume    = {6},
  journal   = {Heliyon},
  number    = {9},
  publisher = {Elsevier},
  address   = {London [u.a.]},
  issn      = {2405-8440},
  doi       = {10.1016/j.heliyon.2020.e04776},
  pages     = {7},
  year      = {2020},
  abstract  = {Background: Several standards have been developed to assess methodological quality of systematic reviews (SR). One widely used tool is the AMSTAR. A recent update -AMSTAR 2 -is a 16 item evaluation tool that enables a detailed assessment of SR that include randomised (RCT) or non-randomised studies (NRS) of healthcare interventions. Methods: A cross-sectional study of SR on pharmacological or psychological interventions in major depression in adults was conducted. SR published during 2012-2017 were sampled from MEDLINE, EMBASE and the Cochrane Database of SR. Methodological quality was assessed using AMSTAR 2. Potential predictive factors associated with quality were examined. Results: In rating overall confidence in the results of 60 SR four reviews were rated "high", two were "moderate", one was "low" and 53 were "critically low". The mean AMSTAR 2 percentage score was 45.3\% (standard deviation 22.6\%) in a wide range from 7.1\% to 93.8\%. Predictors of higher quality were: type of review (higher quality in Cochrane Reviews), SR including only randomized trials and higher journal impact factor. Limitations: AMSTAR 2 is not intended to be used for the generation of a percentage score. Conclusions: According to AMSTAR 2 the overall methodological quality of SR on the treatment of adult major depression needs improvement. Although there is a high need for summarized information in the field of mental health, this work demonstrates the need to critically assess SR before using their findings. Better adherence to established reporting guidelines for SR is needed.},
  language  = {en}
}
@article{KuehneAyBrysonMarschneretal.2020,
  author    = {K{\"u}hne, Franziska and Ay-Bryson, Destina Sevde and Marschner, Linda and Weck, Florian},
  title     = {The heterogeneous course of OCD},
  series = {Psychiatry research : the official publication of the International Society for Neuroimaging in Psychiatry},
  volume    = {285},
  journal   = {Psychiatry research : the official publication of the International Society for Neuroimaging in Psychiatry},
  publisher = {Elsevier},
  address   = {Clare},
  issn      = {0165-1781},
  doi       = {10.1016/j.psychres.2020.112821},
  pages     = {7},
  year      = {2020},
  abstract  = {Although effective treatments exist, obsessive-compulsive disorder (OCD) is, according to the views of patients and experts, still associated with chronicity, a term with no clear and consistent definition. To improve patient care and to foster research, a clear distinction between the various concepts of chronicity cited in the literature is crucial. The aim was thus to explicate central concepts related to courses and trajectories in OCD based on an explorative, scoping search of the existing literature. Our review revealed a considerable lack in content validity, as the concepts were operationalized inconsistently. Concepts related to symptom improvement were (complete) recovery, partial/full remission and partial/full response. Terms used in relation with symptom stability or worsening were chronic/continuous, intermittent and episodic course, waxing and waning, relapse, recurrence, deterioration and treatment-refractoriness. All concepts are explained and visualized as a result of the review. Further, based on authors' remarks, we present recommendations on how to enhance care for chronic OCD patients, namely training psychotherapists to apply CBT as intended, managing patient beliefs about disease and treatment, and adapting psychotherapy to OCD subtypes. Finally, we then propose a literature-based definition of treatment-refractory OCD.},
  language  = {en}
}