@article{KurbanogluYarman2020,
  author    = {Kurbanoglu, Sevinc and Yarman, Aysu},
  title     = {Simultaneous determination of hydrochlorothiazide and irbesartan from pharmaceutical dosage forms with RP-HPLC},
  series = {Turkish journal of pharmaceutical sciences},
  volume    = {17},
  journal   = {Turkish journal of pharmaceutical sciences},
  number    = {5},
  publisher = {Turkish Pharmacists Association},
  address   = {{\c{C}}ankaya-Ankara},
  issn      = {1304-530X},
  doi       = {10.4274/tjps.galenos.2019.76094},
  pages     = {523 -- 527},
  year      = {2020},
  abstract  = {Objectives: In this work, a simple and rapid liquid chromatographic method for the simultaneous determination of irbesartan (IRBE) and hydrochlorothiazide (HCT) was developed and validated by reverse phase high performance liquid chromatography (RP-HPLC). <br /> Materials and Methods: Experimental conditions such as different buffer solutions, various pH values, temperature, composition of the mobile phase, and the effect of flow rate were optimized. <br /> Results: The developed RP-HPLC method for these antihypertensive agents was wholly validated and IRBE was detected in the linear range of 0.1-25 mu g mL(-1) and HCT was detected in the linear range of 0.25-25 mu g mL(-1). Moreover, the suggested chromatographic technique was successfully applied for the determination of the drugs in human serum and pharmaceutical dosage forms with limit of detection values of 0.008 mu g mL(-1) for IRBE and 0.012 mu g mL(-1) for HCT. <br /> Conclusion: The proposed rapid analysis method of these antihypertensive drugs can be easily used and applied by pharmaceutical companies for which the analysis time is important.},
  language  = {en}
}