@misc{HarmsScalbertZamoraRosetal.2020,
  author    = {Harms, Laura M. and Scalbert, Augustin and Zamora-Ros, Raul and Rinaldi, Sabina and Jenab, Mazda and Murphy, Neil and Achaintre, David and Tj{\o}nneland, Anne and Olsen, Anja and Overvad, Kim and Aleksandrova, Krasimira},
  title     = {Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {2},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-51577},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-515774},
  pages     = {13},
  year      = {2020},
  abstract  = {Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 \% CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 \% CI 50, 1) \% lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0 center dot 66, 95 \% CI 0 center dot 46, 0 center dot 96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0 center dot 58, 95 \% CI 0 center dot 39, 0 center dot 86), 3,4-dihydroxyphenylpropionic acid (OR 0 center dot 63, 95 \% CI 0 center dot 46, 0 center dot 87), ferulic acid (OR 0 center dot 65, 95 \% CI 0 center dot 44, 0 center dot 96) and caffeic acid (OR 0 center dot 69, 95 \% CI 0 center dot 51, 0 center dot 93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0 center dot 67, 95 \% CI 0 center dot 48, 0 center dot 93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.},
  language  = {en}
}
@article{HarmsScalbertZamoraRosetal.2019,
  author    = {Harms, Laura M. and Scalbert, Augustin and Zamora-Ros, Raul and Rinaldi, Sabina and Jenab, Mazda and Murphy, Neil and Achaintre, David and Tj{\o}nneland, Anne and Olsen, Anja and Overvad, Kim and Aleksandrova, Krasimira},
  title     = {Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations},
  series = {British Journal of Nutrition},
  volume    = {123},
  journal   = {British Journal of Nutrition},
  number    = {2},
  publisher = {Cambridge University Press},
  address   = {Cambridge},
  issn      = {0007-1145},
  doi       = {10.1017/S0007114519002538},
  pages     = {198 -- 208},
  year      = {2019},
  abstract  = {Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 \% CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 \% CI 50, 1) \% lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0 center dot 66, 95 \% CI 0 center dot 46, 0 center dot 96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0 center dot 58, 95 \% CI 0 center dot 39, 0 center dot 86), 3,4-dihydroxyphenylpropionic acid (OR 0 center dot 63, 95 \% CI 0 center dot 46, 0 center dot 87), ferulic acid (OR 0 center dot 65, 95 \% CI 0 center dot 44, 0 center dot 96) and caffeic acid (OR 0 center dot 69, 95 \% CI 0 center dot 51, 0 center dot 93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0 center dot 67, 95 \% CI 0 center dot 48, 0 center dot 93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.},
  language  = {en}
}
@misc{HassHerpichNorman2019,
  author    = {Haß, Ulrike and Herpich, Catrin and Norman, Kristina},
  title     = {Anti-Inflammatory Diets and Fatigue},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {803},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-44117},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441172},
  pages     = {26},
  year      = {2019},
  abstract  = {Accumulating data indicates a link between a pro-inflammatory status and occurrence of chronic disease-related fatigue. The questions are whether the observed inflammatory profile can be (a) improved by anti-inflammatory diets, and (b) if this improvement can in turn be translated into a significant fatigue reduction. The aim of this narrative review was to investigate the effect of anti-inflammatory nutrients, foods, and diets on inflammatory markers and fatigue in various patient populations. Next to observational and epidemiological studies, a total of 21 human trials have been evaluated in this work. Current available research is indicative, rather than evident, regarding the effectiveness of individuals' use of single nutrients with anti-inflammatory and fatigue-reducing effects. In contrast, clinical studies demonstrate that a balanced diet with whole grains high in fibers, polyphenol-rich vegetables, and omega-3 fatty acid-rich foods might be able to improve disease-related fatigue symptoms. Nonetheless, further research is needed to clarify conflicting results in the literature and substantiate the promising results from human trials on fatigue.},
  language  = {en}
}
@article{HassHerpichNorman2019,
  author    = {Haß, Ulrike and Herpich, Catrin and Norman, Kristina},
  title     = {Anti-Inflammatory Diets and Fatigue},
  series = {Nutrients},
  volume    = {11},
  journal   = {Nutrients},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6643},
  doi       = {10.3390/nu11102315},
  pages     = {24},
  year      = {2019},
  abstract  = {Accumulating data indicates a link between a pro-inflammatory status and occurrence of chronic disease-related fatigue. The questions are whether the observed inflammatory profile can be (a) improved by anti-inflammatory diets, and (b) if this improvement can in turn be translated into a significant fatigue reduction. The aim of this narrative review was to investigate the effect of anti-inflammatory nutrients, foods, and diets on inflammatory markers and fatigue in various patient populations. Next to observational and epidemiological studies, a total of 21 human trials have been evaluated in this work. Current available research is indicative, rather than evident, regarding the effectiveness of individuals' use of single nutrients with anti-inflammatory and fatigue-reducing effects. In contrast, clinical studies demonstrate that a balanced diet with whole grains high in fibers, polyphenol-rich vegetables, and omega-3 fatty acid-rich foods might be able to improve disease-related fatigue symptoms. Nonetheless, further research is needed to clarify conflicting results in the literature and substantiate the promising results from human trials on fatigue.},
  language  = {en}
}
@misc{LamyRawelSchweigertetal.2011,
  author    = {Lamy, Elsa and Rawel, Harshadrai Manilal and Schweigert, Florian J. and Capela e Silva, Fernando and Ferreira, Ana and Costa, Ana Rodrigues and Antunes, Celia and Almeida, Andre Martinho and Coelho, Ana Varela and Sales-Baptista, Elvira},
  title     = {The effect of tannins on mediterranean ruminant ingestive behavior the role of the oral cavity},
  series = {Molecules},
  volume    = {16},
  journal   = {Molecules},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1420-3049},
  doi       = {10.3390/molecules16042766},
  pages     = {2766 -- 2784},
  year      = {2011},
  abstract  = {Sheep, cattle and goat are domestic ruminants of significant economic interest in the Mediterranean region. Although sharing the same pasture ranges, they ingest different plants and plant parts and, consequently different levels of tannins. This suggests an ability to detect and adapt ingestion according to animal physiological limits of tolerance for plant secondary metabolites. This review will detail the effects of dietary tannins on feeding behavior, and the role of the oral cavity in this process, with focus on such ruminant species. The role of salivary protein profile in tannin perception in the oral cavity, and as a defense mechanism, will be discussed.},
  language  = {en}
}
@phdthesis{Gruendel2007,
  author    = {Gr{\"u}ndel, Sindy},
  title     = {Akuteffekte des polyphenolreichen unl{\"o}slichen Carobballaststoffes auf Parameter des Metabolischen Syndroms bei gesunden Erwachsenen},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-14899},
  school      = {Universit{\"a}t Potsdam},
  year      = {2007},
  abstract  = {Das Metabolische Syndrom stellt eine Kombination verschiedener metabolischer Anomalien in einem Individuum dar. Starkes {\"U}bergewicht gilt als maßgebende Gr{\"o}ße in der Genese des Syndroms, welches mit einem enormen Risiko f{\"u}r kardiovaskul{\"a}re Erkrankungen einhergeht. Um die stark steigende Pr{\"a}valenz des Metabolischen Syndroms einzud{\"a}mmen, sind dringend Konzepte f{\"u}r die Behandlung, vor allem jedoch f{\"u}r die Pr{\"a}vention von {\"U}bergewicht erforderlich. Einen wichtigen Beitrag leisten diesbez{\"u}glich Ballaststoffe in der Ern{\"a}hrung. Sie tragen auf unterschiedlichen Wegen zur Gewichtskontrolle bei und beeinflussen zudem verschiedene mit dem Metabolischen Syndrom assoziierte Blutparameter. Ebenso werden protektive Effekte von Polyphenolen, welche zur Gruppe der sekund{\"a}ren Pflanzenstoffe z{\"a}hlen, beschrieben. Diese wirken u. a. auf den Glukose- sowie den Insulinhaushalt und greifen dar{\"u}ber hinaus in die Regulation der Fettverbrennung sowie des Energieverbrauches ein. Die Kombination beider Substanzgruppen verspricht bedeutendes gesundheitsf{\"o}rderndes Potential; dieses wurde gegenw{\"a}rtig jedoch kaum untersucht. Carobballaststoff ist ein polyphenolreicher und vorwiegend unl{\"o}slicher Extrakt der Frucht des Johannisbrotbaumes (Ceratonia siliqua L). Bislang publizierte Studien zur physiologischen Wirksamkeit dieses Ballaststoffpr{\"a}parates weisen sowohl beim Tier als auch beim Menschen bemerkenswerte hypocholesterin{\"a}mische Eigenschaften nach. Inwiefern sich der Verzehr des Carobballaststoffes ebenso auf die Entwicklung von {\"U}bergewicht sowie anderen Messgr{\"o}ßen des Metabolischen Syndroms auswirkt, ist allerdings nicht bekannt. Die Zielstellung der Promotionsarbeit bestand darin, die postprandialen Wirkungen des Carobballaststoffverzehrs mit Hilfe einer Humanstudie aufzuzeigen. In die randomisierten, einfach verblindeten Untersuchungen im cross-over-Design wurden 20 gesunde Erwachsene im Alter zwischen 22 und 62 Jahren eingeschlossen. Unter Verwendung variierender Begleitmahlzeiten wurden die postprandialen Effekte verschiedener Mengen des Carobballaststoffes untersucht. Hierbei standen die Ver{\"a}nderungen der Plasmakonzentrationen von Glukose, Triglyceriden (TG), totalem und acyliertem Ghrelin sowie der Serumkonzentrationen von Insulin und nicht-veresterten Fetts{\"a}uren (NEFA) im Mittelpunkt der Betrachtungen. Der Verzehr des Carobballaststoffes in Kombination mit 200 ml Wasser und 50 g Glukose erh{\"o}hte die postprandialen Glukose- und Insulinkonzentrationen gegen{\"u}ber der Glukosel{\"o}sung ohne Ballaststoffzusatz. In Kombination mit 400 ml einer Fl{\"u}ssigmahlzeit verzehrt, senkte Carobballaststoff die postprandialen TG-, NEFA- und Ghrelin- (acyliert) Antworten. Die Untersuchung des respiratorischen Quotienten nach Zusatz von Carobballaststoff zur Fl{\"u}ssigmahlzeit mittels indirekter Respirationskalorimetrie bekr{\"a}ftigte die bereits bekannten Effekte auf den Lipidmetabolismus und wies zudem eine Steigerung der Fettverwertung unter Verminderung der Glukoseoxidation nach. Wurde Carobballaststoff schließlich in Lebensmittel eingebracht, sanken nach dem Verzehr dieser Lebensmittel erneut die postprandialen Konzentrationen an TG und NEFA. Gleichzeitig erh{\"o}hten sich die Glukose-, Insulin- sowie Ghrelin- (acyliert) Antworten. Carobballaststoff l{\"o}st in Abh{\"a}ngigkeit von der jeweils verzehrten Begleitmatrix unterschiedliche Effekte aus. Das Pr{\"a}parat weist beachtliche Wirkungen auf die Blutlipide sowie den Energieverbrauch auf, hat indes ung{\"u}nstige Wirkungen auf die Blutglukose, sofern er in Kombination mit einer ver{\"a}nderten N{\"a}hrstoffmatrix aufgenommen wird. Carobballaststoff besitzt starkes gesundheitsf{\"o}rderndes Potential; jedoch sind weitere Studien notwendig, um seine Wirkungen sowie deren Voraussetzungen besser zu verstehen. Ferner sollten Untersuchungen {\"u}ber einen l{\"a}ngeren Zeitraum vorgenommen werden, um die langfristige Relevanz der gewonnenen Ergebnisse darzulegen. Danach stellt die Anreicherung spezieller Lebensmittel mit Carobballaststoff einen geeigneten Weg dar, um von den viel versprechenden protektiven Wirkungen des Pr{\"a}parates zu profitieren.},
  language  = {de}
}