@techreport{KirchnerPrinzRichteretal.2024, type = {Working Paper}, author = {Kirchner, Jan-Robert and Prinz, Andreas and Richter, Martin and Str{\"a}tling, Ansgar}, title = {Bilanzierungshilfe nach NKF-CUIG im kommunalen Haushaltsrecht in NRW}, series = {ifV - Positionspapier}, journal = {ifV - Positionspapier}, organization = {Institut f{\"u}r Verwaltungswissenschaften gGmbH}, doi = {10.25932/publishup-63615}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-636159}, pages = {28}, year = {2024}, abstract = {Durch die Covid-19-Pandemie und den Ukraine- Krieg sind den Kommunen erhebliche finanzielle Mehrbelastungen in Form von zus{\"a}tzlichen Aufwendungen und Minderertr{\"a}gen entstanden. Das Land NRW hatte daher mit dem „Gesetz zur Isolierung der aus der Covid-19-Pandemie folgenden Belastungen der kommunalen Haushalte im Land Nordrhein-Westfalen (NKF-COVID-19- Isolierungsgesetz - NKF-CIG)" vom 29. September 2020 beschlossen, befristet die Aufstellung der Haushalte zu erleichtern und finanzielle Mehrbelastungen bilanziell zu „isolieren". Mit dem ersten {\"A}nderungsgesetz vom 1. Dezember 2021 wurden die Regelungen {\"u}berarbeitet und der Geltungszeitraum verl{\"a}ngert. Mit dem zweiten {\"A}nderungsgesetz vom 9. Dezember 2022 erfolgte eine sachliche und zeitliche Erweiterung. Gleichzeitig wurde das Gesetz umbenannt, um die sachliche Erweiterung um die finanziellen Mehrbelastungen aus dem Ukraine-Krieg zu verdeutlichen (NKF-CUIG). Unser Positionspapier setzt sich in einem ersten Schritt kritisch mit der bilanziellen „Isolierung" dieser finanziellen Mehrbelastungen mittels Bilanzierungshilfe auseinander und identifiziert sowohl die Herausforderungen bei der genauen Bestimmung dieser finanziellen Mehrbelastungen als auch die Anwendungsprobleme bei der Bildung, dem Ausweis und der Bewertung dieser Bilanzierungshilfe im kommunalen Jahresabschluss. In einem zweiten Schritt werden die Auswirkungen der Bilanzierung einer solchen Bilanzierungshilfe auf die Pr{\"u}fung des Jahresabschlusses eingehend untersucht und kritisch diskutiert. In einem dritten Schritt wird eine rechtspolitische Bewertung des NKF-CUIG vorgenommen. Zusammenfassend ist festzuhalten, dass eine „Hilfe", wie sie der Begriff der Bilanzierungshilfe im pragmatischen Sprachgebrauch suggeriert, in keiner Weise festzustellen ist. Auch in Zukunft ist mit Situationen zu rechnen, die der Covid-Pandemie und dem Ukraine-Krieg vergleichbar sind. Auch dann k{\"o}nnten finanzielle Mehrbelastungen die rechtliche Handlungsf{\"a}higkeit der Kommunen gef{\"a}hrden. Um diese zu erhalten, sollten vom Landesgesetzgeber jedoch andere Maßnahmen als die Aktivierung einer Bilanzierungshilfe in Betracht gezogen werden. Die alternativen Maßnahmen sollten einerseits den Besonderheiten der historischen Situation und dem Ziel des Erhalts der rechtlichen Handlungsf{\"a}higkeit der Kommunen gerecht werden. Sie sollten gleichzeitig aber auch Systembr{\"u}che in der Doppik und im Haushaltsrecht sowie unn{\"o}tige B{\"u}rokratielasten vermeiden.}, language = {de} } @article{XuXuSchultzetal.2023, author = {Xu, Wenlei and Xu, Yaolin and Schultz, Thorsten and Lu, Yan and Koch, Norbert and Pinna, Nicola}, title = {Heterostructured and mesoporous Nb2O5@TiO2 core-shell spheres as the negative electrode in Li-ion batteries}, series = {ACS applied materials \& interfaces}, volume = {15}, journal = {ACS applied materials \& interfaces}, number = {1}, publisher = {American Chemical Society}, address = {Washington}, issn = {1944-8244}, doi = {10.1021/acsami.2c15124}, pages = {795 -- 805}, year = {2023}, abstract = {Niobium pentoxides have received considerable attention and are promising anode materials for lithium-ion batteries (LIBs), due to their fast Li storage kinetics and high capacity. However, their cycling stability and rate performance are still limited owing to their intrinsic insulating properties and structural degradation during charging and discharging. Herein, a series of mesoporous Nb2O5@TiO2 core-shell spherical heterostructures have been prepared for the first time by a sol-gel method and investigated as anode materials in LIBs. Mesoporosity can provide numerous open and short pathways for Li+ diffusion; meanwhile, heterostructures can simultaneously enhance the electronic conductivity and thus improve the rate capability. The TiO2 coating layer shows robust crystalline skeletons during repeated lithium insertion and extraction processes, retaining high structural integrity and, thereby, enhancing cycling stability. The electrochemical behavior is strongly dependent on the thickness of the TiO2 layer. After optimization, a mesoporous Nb2O5@TiO2 core-shell structure with a similar to 13 nm thick TiO2 layer delivers a high specific capacity of 136 mA h g-1 at 5 A g-1 and exceptional cycling stability (88.3\% retention over 1000 cycles at 0.5 A g-1). This work provides a facile strategy to obtain mesoporous Nb2O5@TiO2 core-shell spherical structures and underlines the importance of structural engineering for improving the performance of battery materials.}, language = {en} } @article{DasBroseMeyeretal.2022, author = {Das, Samata and Brose, Robert and Meyer, Dominique M.-A. and Pohl, Martin and Sushch, Iurii and Plotko, Pavlo}, title = {Spectral softening in core-collapse supernova remnant expanding inside wind-blown bubble☆}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {661}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/202142747}, pages = {13}, year = {2022}, abstract = {Context. Galactic cosmic rays (CRs) are widely assumed to arise from diffusive shock acceleration, specifically at shocks in supernova remnants (SNRs). These shocks expand in a complex environment, particularly in the core-collapse scenario as these SNRs evolve inside the wind-blown bubbles created by their progenitor stars. The CRs at core-collapse SNRs may carry spectral signatures of that complexity. Aims. We study particle acceleration in the core-collapse SNR of a progenitor with an initial mass of 60 M-circle dot and realistic stellar evolution. The SNR shock interacts with discontinuities inside the wind-blown bubble and generates several transmitted and reflected shocks. We analyse their impact on particle spectra and the resulting emission from the remnant. Methods. To model the particle acceleration at the forward shock of a SNR expanding inside a wind bubble, we initially simulated the evolution of the pre-supernova circumstellar medium (CSM) by solving the hydrodynamic equations for the entire lifetime of the progenitor star. As the large-scale magnetic field, we considered parameterised circumstellar magnetic field with passive field transport. We then solved the hydrodynamic equations for the evolution of a SNR inside the pre-supernova CSM simultaneously with the transport equation for CRs in test-particle approximation and with the induction equation for the magnetohydrodynamics in 1D spherical symmetry. Results. The evolution of a core-collapse SNR inside a complex wind-blown bubble modifies the spectra of both the particles and their emission on account of several factors including density fluctuations, temperature variations, and the magnetic field configuration. We find softer particle spectra with spectral indices close to 2.5 during shock propagation inside the shocked wind, and this softness persists at later evolutionary stages. Further, our calculated total production spectrum released into the interstellar medium demonstrates spectral consistency at high energy (HE) with the injection spectrum of Galactic CRs, which is required in propagation models. The magnetic field structure effectively influences the emission morphology of SNRs as it governs the transportation of particles and the synchrotron emissivity. There is rarely a full correspondence of the intensity morphology in the radio, X-ray, and gamma-ray bands.}, language = {en} } @article{AnthymidisPapazachosOhrnbergeretal.2022, author = {Anthymidis, Marios and Papazachos, Costas and Ohrnberger, Matthias and Savvaidis, Alexandros and Theodoulidis, Nikos and Oikonomou, Dimitris}, title = {Evaluation of the 3D near-surface velocity structure in an urban environment from ambient noise array tomography: the case of the city of Thessaloniki (Northern Greece)}, series = {The bulletin of the Seismological Society of America : BSSA}, volume = {112}, journal = {The bulletin of the Seismological Society of America : BSSA}, number = {5}, publisher = {Seismological Society of America}, address = {El Cerito, Calif.}, issn = {0037-1106}, doi = {10.1785/0120220004}, pages = {2587 -- 2605}, year = {2022}, abstract = {We examine the implementation of ambient noise array tomography in an urban environment to assess the 3D near-surface shear wave velocity (VS) structure at an intermediate spatial scale (-1 km2, depth range 200-300 m). The application employs cross correlation traces of vertical component ambient noise recordings from a local network installed in Thessaloniki city (Northern Greece), allowing the determination of Rayleigh wave travel times for the frequency range of 1.5-14 Hz. The results confirm the presence of a complex subsurface with strong lateral variations in the geology, with travel times varying up to almost one order of magnitude. A surface wave travel time tomography approach was applied for each frequency to determine the spatial variability of the group velocity, involving the use of approximate Fresnel volumes, as well as damping and spatial smoothing constraints to stabilize the results. We also employed an interfrequency smoothing scheme to obtain smooth but data-compatible dispersion curves at the cost of inverting all travel time data simultaneously. Following the application of several quality cutoff criteria, we reconstructed local group slowness dispersion curves for a predefined tomographic grid in the study area. The final 3D velocity model was determined by a modified Monte Carlo inversion of these dispersion curves and the spatial integration of the obtained 1D VS profiles. Different model parameterizations were tested for the inversion to determine the optimal datafit. The final 3D velocity model is in a very good agreement with the local geology, previous larger scale studies, and other geophysical surveys, providing additional structural constraints (such as hidden fault identification) for the complex sedimentary deposits and bedrock formation in Thessaloniki, up to the depth of - 250-300 m. The introduction of the aforementioned modifications to the ambient noise array tomography suggests that it can be efficiently adjusted and employed as a reliable tool for imaging the 3D seismic structure in urban environments with complex geology.}, language = {en} } @article{PradaWittenbecherEichelmannetal.2022, author = {Prada, Marcela and Wittenbecher, Clemens and Eichelmann, Fabian and Wernitz, Andreas and Kuxhaus, Olga and Kroeger, Janine and Weikert, Cornelia and Schulze, Matthias B.}, title = {Plasma industrial and ruminant trans fatty acids and incident type 2 diabetes in the EPIC-Potsdam cohort}, series = {Diabetes care}, volume = {45}, journal = {Diabetes care}, number = {4}, publisher = {American Diabetes Association}, address = {Alexandria, Va.}, issn = {0149-5992}, doi = {10.2337/dc21-1897}, pages = {845 -- 853}, year = {2022}, abstract = {OBJECTIVEAlthough dietary intake of trans fatty acid (TFA) is a major public health concern because of the associated increase in the risk of cardiovascular events, it remains unclear whether TFAs also influence risk of type 2 diabetes (T2D) and whether industrial TFAs (iTFAs) and ruminant TFAs (rTFAs) exert the same effect on health. RESEARCH DESIGN AND METHODSTo investigate the relationship of 7 rTFAs and iTFAs, including 2 conjugated linoleic acids (CLAs), plasma phospholipid TFAs were measured in a case-cohort study nested within the European Prospective Investigation Into Cancer and Nutrition-Potsdam cohort. The analytical sample was a random subsample (n = 1,248) and incident cases of T2D (n = 801) over a median follow-up of 6.5 years. Using multivariable Cox regression models, we examined associations of TFAs with incident T2D. RESULTSThe TFA subtypes were intercorrelated with each other, with other fatty acids, and with different food sources. After controlling for other TFAs, the iTFAs (18:1n-6t, 18:1n-9t, 18:2n-6,9t) were not associated with diabetes risk. Some rTFA subtypes were inversely associated with diabetes risk: vaccenic acid (18:1n-7t; hazard ratio [HR] per SD 0.72; 95\% CI 0.58-0.89) and t10c12-CLA (HR per SD 0.81; 95\% CI 0.70-0.94), whereas c9t11-CLA was positively associated (HR per SD 1.39; 95\% CI 1.19-1.62). Trans-palmitoleic acid (16:1n-7t) was not associated with diabetes risk when adjusting for the other TFAs (HR per SD 1.08; 95\% CI 0.88-1.31). CONCLUSIONSThe TFAs' conformation plays an essential role in their relationship to diabetes risk. rTFA subtypes may have opposing relationships to diabetes risk. Previous observations for reduced diabetes risk with higher levels of circulating trans-palmitoleic acid are likely due to confounding.}, language = {en} } @article{MaierWiedermannBurdinskietal.2022, author = {Maier, Benjamin F. and Wiedermann, Marc and Burdinski, Angelique and Klamser, Pascal P. and Jenny, Mirjam A. and Betsch, Cornelia and Brockmann, Dirk}, title = {Germany's fourth COVID-19 wave was mainly driven by the unvaccinated}, series = {Communications medicine}, volume = {2}, journal = {Communications medicine}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2730-664X}, doi = {10.1038/s43856-022-00176-7}, pages = {9}, year = {2022}, abstract = {Background While the majority of the German population was fully vaccinated at the time (about 65\%), COVID-19 incidence started growing exponentially in October 2021 with about 41\% of recorded new cases aged twelve or above being symptomatic breakthrough infections, presumably also contributing to the dynamics. So far, it remained elusive how significant this contribution was and whether targeted non-pharmaceutical interventions (NPIs) may have stopped the amplification of the crisis.
Methods We develop and introduce a contribution matrix approach based on the nextgeneration matrix of a population-structured compartmental infectious disease model to derive contributions of respective inter- and intragroup infection pathways of unvaccinated and vaccinated subpopulations to the effective reproduction number and new infections, considering empirical data of vaccine efficacies against infection and transmission.
Results Here we show that about 61\%-76\% of all new infections were caused by unvaccinated individuals and only 24\%-39\% were caused by the vaccinated. Furthermore, 32\%-51\% of new infections were likely caused by unvaccinated infecting other unvaccinated. Decreasing the transmissibility of the unvaccinated by, e. g. targeted NPIs, causes a steeper decrease in the effective reproduction number R than decreasing the transmissibility of vaccinated individuals, potentially leading to temporary epidemic control. Reducing contacts between vaccinated and unvaccinated individuals serves to decrease R in a similar manner as increasing vaccine uptake.
Conclusions A minority of the German population-the unvaccinated-is assumed to have caused the majority of new infections in the fall of 2021 in Germany. Our results highlight the importance of combined measures, such as vaccination campaigns and targeted contact reductions to achieve temporary epidemic control.}, language = {en} } @article{ThormannBetaKuhn2022, author = {Thormann, Kai M. and Beta, Carsten and Kuhn, Marco J.}, title = {Wrapped up}, series = {Annual review of microbiology}, volume = {76}, journal = {Annual review of microbiology}, publisher = {Annual Reviews Inc.}, address = {Palo Alto}, issn = {0066-4227}, doi = {10.1146/annurev-micro-041122-101032}, pages = {349 -- 367}, year = {2022}, abstract = {A huge number of bacterial species are motile by flagella, which allow them to actively move toward favorable environments and away from hazardous areas and to conquer new habitats. The general perception of flagellum-mediated movement and chemotaxis is dominated by the Escherichia coli paradigm, with its peritrichous flagellation and its famous run-and-tumble navigation pattern, which has shaped the view on how bacteria swim and navigate in chemical gradients. However, a significant amount-more likely the majority-of bacterial species exhibit a (bi)polar flagellar localization pattern instead of lateral flagella. Accordingly, these species have evolved very different mechanisms for navigation and chemotaxis. Here, we review the earlier and recent findings on the various modes of motility mediated by polar flagella.}, language = {en} } @article{WelbySpinelliBuerki2022, author = {Welby, Pauline and Spinelli, Elsa and B{\"u}rki, Audrey}, title = {Spelling provides a precise (but sometimes misplaced) phonological target}, series = {Journal of phonetics}, volume = {94}, journal = {Journal of phonetics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0095-4470}, doi = {10.1016/j.wocn.2022.101172}, pages = {16}, year = {2022}, abstract = {L1 French participants learned novel L2 English words over two days of learning sessions, with half of the words presented with their orthographic forms (Audio-Ortho) and half without (Audio only). One group heard the words pronounced by a single talker, while another group heard them pronounced by multiple talkers. On the third day, they completed a variety of tasks to evaluate their learning. Our results show a robust influence of orthogra-phy, with faster response times in both production (Picture naming) and recognition (Picture mapping) tasks for words learned in the Audio-Ortho condition. Moreover, formant analyses of the Picture naming responses show that orthographic input pulls pronunciations of English novel words towards a non-native (French) phonological target. Words learned with their orthographic forms were pronounced more precisely (with smaller Dispersion Scores), but were misplaced in the vowel space (as reflected by smaller Euclidian distances with respect to French vowels). Finally, we found only limited evidence of an effect of talker-based acoustic variability: novel words learned with multiple talkers showed faster responses times in the Picture naming task, but only in the Audio-only condition, which suggests that orthographic information may have overwhelmed any advantage of talker-based acoustic variability.CO 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).}, language = {en} } @article{BuschFeldmannKuehnetal.2021, author = {Busch, Johannes L. and Feldmann, Lucia K. and Kuehn, Andrea A. and Rosenblum, Michael}, title = {Real-time phase and amplitude estimation of neurophysiological signals exploiting a non-resonant oscillator}, series = {Experimental neurology}, volume = {347}, journal = {Experimental neurology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0014-4886}, doi = {10.1016/j.expneurol.2021.113869}, pages = {4}, year = {2021}, abstract = {A recent advancement in the field of neuromodulation is to adapt stimulation parameters according to prespecified biomarkers tracked in real-time. These markers comprise short and transient signal features, such as bursts of elevated band power. To capture these features, instantaneous measures of phase and/or amplitude are employed, which inform stimulation adjustment with high temporal specificity. For adaptive neuromodulation it is therefore necessary to precisely estimate a signal's phase and amplitude with minimum delay and in a causal way, i.e. without depending on future parts of the signal. Here we demonstrate a method that utilizes oscillation theory to estimate phase and amplitude in real-time and compare it to a recently proposed causal modification of the Hilbert transform. By simulating real-time processing of human LFP data, we show that our approach almost perfectly tracks offline phase and amplitude with minimum delay and is computationally highly efficient.}, language = {en} } @article{ArkesAbereggArpin2022, author = {Arkes, Hal R. and Aberegg, Scott K. and Arpin, Kevin A.}, title = {Analysis of physicians' probability estimates of a medical outcome based on a sequence of events}, series = {Obstetrical \& gynecological survey}, volume = {77}, journal = {Obstetrical \& gynecological survey}, number = {12}, publisher = {Lippincott, Williams \& Wilkins}, address = {Philadelphia}, issn = {0029-7828}, doi = {10.1097/01.ogx.0000905284.72687.a0}, pages = {719 -- 721}, year = {2022}, abstract = {A basic law of probability is that the probability of a conjunction of 2 independent events is the product of both components and cannot exceed the likelihood of either component. When this basic law is violated, it is known as the conjunction fallacy. In clinical practice, the conjunction fallacy may arise when physicians estimate the probability of the overall outcome that requires >= 2 steps to be successful. For example, if a successful procedure requires the success of step A and step B, then the probability of overall success of the procedure cannot exceed the likelihood of success of either step A or step B. The aim of this study was to determine whether physicians could correctly estimate the overall probability of success from 2 independent events.
This was a 3-part, Internet-based survey study designed to evaluate the presence of the conjunction fallacy in 2 separate obstetric contexts and 1 pulmonary context. Respondents were board-certified or board-eligible physicians in obstetrics and gynecology and pulmonary, recruited from a commercial survey service. In each context, physicians were presented with scenarios related to their medical specialty and asked to judge the probability of the overall outcome, or conjunction, and of the 2 individual events, or conjuncts.
The first substudy, conducted April 2-4, 2021, described a delivery in brow presentation discovered during labor. To assess the overall probability of a successful spontaneous vaginal delivery, an obstetrician must consider the likelihood of the brow presentation converting to a deliverable position and the likelihood of vaginal delivery from the converted position. The second substudy, conducted November 2-11, 2021, described the diagnostic evaluation of pulmonary nodule discovered incidentally. To assess the overall probability that a biopsy reveals cancer, the physician must consider the likelihood that the nodule is cancerous and the likelihood that the biopsy successfully and accurately detects cancer. The third study, conducted May 13-19, 2021, modified the first substudy and asked responding obstetricians to consider the likelihood of the individual conjuncts before estimating the overall probability of successful vaginal delivery.
The survey included responses from 215 physicians: 66\% were male and 34\% were female with a mean (SD) age of 53.6 (9.5) years and mean time since obtaining a medical degree of 27.5 (10.6) years. Overall, 78.1\% of physicians committed the conjunction fallacy, estimating that the overall probability of success was greater than the likelihood of at least 1 of the 2 conjuncts. In the first substudy, 74.6\% of 67 obstetricians committed the conjunction fallacy; respondents overestimated the combined probability by 12.8\% (95\% confidence interval [CI], 9.6\%-16.1\%), compared with the product of the 2 estimated conjuncts with statistically significant deviation (t66 = 7.94; P < 0.001; Cohen d = 0.97 [95\% CI, 0.68-1.26]). In the second substudy, 86.9\% of 84 pulmonologists committed the conjunction fallacy; respondents overestimated the combined probability by 19.8\% (95\% CI, 16.6\%-23.0\%), with statistically significant deviation of (t83 = 7.94; P < 0.001; Cohen d = 1.34 [95\% CI, 1.04-1.64]). In the third substudy, 70.3\% of 64 committed the conjunction fallacy; respondents overestimated the combined probability by 18.0\% (95\% CI, 13.4\%-22.5\%) with statistically significant deviation (t63 = 7.89; P < 0.001; Cohen d = 0.99 [95\% CI, 0.68-1.28]).
In this study, it was common for seasoned obstetricians and pulmonologists to commit the conjunction fallacy. Given that physicians often need to estimate the successful outcome of a multistep procedure, they may be doing so in a flawed manner that may negatively impact decision-making.}, language = {en} } @article{ElHageKnippschildArnoldetal.2022, author = {El Hage, Racha and Knippschild, Uwe and Arnold, Tobias and Hinterseher, Irene}, title = {Stem cell-based therapy : a promising treatment for diabetic foot ulcer}, series = {Biomedicines : open access journal}, volume = {10}, journal = {Biomedicines : open access journal}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2227-9059}, doi = {10.3390/biomedicines10071507}, pages = {22}, year = {2022}, abstract = {Diabetic foot ulcer (DFU) is a severe complication of diabetes and a challenging medical condition. Conventional treatments for DFU have not been effective enough to reduce the amputation rates, which urges the need for additional treatment. Stem cell-based therapy for DFU has been investigated over the past years. Its therapeutic effect is through promoting angiogenesis, secreting paracrine factors, stimulating vascular differentiation, suppressing inflammation, improving collagen deposition, and immunomodulation. It is controversial which type and origin of stem cells, and which administration route would be the most optimal for therapy. We reviewed the different types and origins of stem cells and routes of administration used for the treatment of DFU in clinical and preclinical studies. Diabetes leads to the impairment of the stem cells in the diseased patients, which makes it less ideal to use autologous stem cells, and requires looking for a matching donor. Moreover, angioplasty could be complementary to stem cell therapy, and scaffolds have a positive impact on the healing process of DFU by stem cell-based therapy. In short, stem cell-based therapy is promising in the field of regenerative medicine, but more studies are still needed to determine the ideal type of stem cells required in therapy, their safety, proper dosing, and optimal administration route.}, language = {en} } @book{OPUS4-64326, title = {E‑Learning-Strategie 2023 - 2028}, organization = {E-Learning-Steuerungsgruppe}, doi = {10.25932/publishup-64326}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-643265}, publisher = {Universit{\"a}t Potsdam}, pages = {11}, year = {2024}, abstract = {Die Universit{\"a}t Potsdam positioniert sich als Hochschule im digitalen Zeitalter mit dem Ziel, den umfassenden Einsatz von digitalen Medien in Lehre und Studium als gelebte Lehr-, Lern- und Pr{\"u}fungskultur f{\"u}r alle Studierenden, Lehrenden und Mitarbeitenden zu verwirklichen. Aufbauend auf den Erfahrungen und Vorarbeiten der letzten Jahre, wie der Bestandsaufnahme E-Learning sowie von fr{\"u}heren Strategien und Leitbildern, mit denen digitale Medien zunehmend in Lehre und Studium integriert wurden, verf{\"u}gt die Universit{\"a}t Potsdam {\"u}ber eine starke Ausgangsposition im Bereich der digitalen Lehre. Daher zielt die aktuelle E-Learning-Strategie (2023-2028) auf die Weiterentwicklung und Verstetigung dieser Ans{\"a}tze. Sie identifiziert dabei sechs zentrale Handlungsfelder: "Austausch und Vernetzung", "Content", "Innovation und Verstetigung", "Medienkompetenz", "Qualitätsentwicklung" und "UP und die Welt". Die Strategie wurde im Rahmen eines partizipativen Prozesses entwickelt, der von der E-Learning-Steuerungsgruppe koordiniert und von Vertreter*innen aus allen Bereichen und allen Statusgruppen der Universit{\"a}t unterst{\"u}tzt wurde. Sie wurde in der 319. Sitzung des Senats am 5. Juli 2023 beschlossen und mit redaktionellen {\"A}nderungen 2024 ver{\"o}ffentlicht.}, language = {de} } @article{DecristaDumont2021, author = {Decrista, Jasmin and Dumont, Hanna}, title = {Individuelle F{\"o}rderung und Differenzierung im Unterricht}, series = {Handbuch Schulpsychologie : Psychologie f{\"u}r die Schule}, journal = {Handbuch Schulpsychologie : Psychologie f{\"u}r die Schule}, edition = {3., {\"u}berarbeitete Auflage}, publisher = {Kohlhammer}, address = {Stuttgart}, isbn = {978-3-17-039787-3}, doi = {10.17433/978-3-17-039787-3}, pages = {308 -- 316}, year = {2021}, language = {de} } @article{Becker2021, author = {Becker, Ulrike}, title = {Sch{\"u}lerinnen und Sch{\"u}ler mit (sonderp{\"a}dagogischen) F{\"o}rderbedarfen in der Schule}, series = {Handbuch Schulpsychologie : Psychologie f{\"u}r die Schule}, journal = {Handbuch Schulpsychologie : Psychologie f{\"u}r die Schule}, edition = {3., {\"u}berarbeitete Auflage}, publisher = {Kohlhammer}, address = {Stuttgart}, isbn = {978-3-17-039787-3}, doi = {10.17433/978-3-17-039787-3}, pages = {192 -- 202}, year = {2021}, language = {de} } @book{OPUS4-65874, title = {Mobbing an Schulen}, editor = {Wachs, Sebastian and Hess, Markus and Scheithauer, Herbert and Schubarth, Wilfried}, publisher = {Kohlhammer}, address = {Stuttgart}, isbn = {978-3-17-030042-2}, pages = {217}, year = {2016}, abstract = {Das Buch beginnt mit einem ausf{\"u}hrlichen Einblick in die Mobbing-Forschung, u. a. zu Merkmalen und Erscheinungsformen von Mobbing. Dar{\"u}ber hinaus werden Ursachen und Folgen von Mobbing, aber auch neue Formen wie das Cyber-Mobbing thematisiert. Im weiteren Verlauf stehen dann das Eingreifen bei und Vorbeugen von Mobbing im Mittelpunkt. Dabei werden etablierte Interventions- und Pr{\"a}ventionsprogramme verst{\"a}ndlich pr{\"a}sentiert, konkrete Empfehlungen gegeben, wie man in Mobbing-Situationen handeln kann, und Gelingensbedingungen beschrieben, wie es gar nicht erst zu Mobbing kommt. Gespickt mit vielen Fallbeispielen und einer ausf{\"u}hrlichen Materialsammlung zum Download wird die Darstellung anschaulich und der praktische Transfer des pr{\"a}sentierten Wissens erleichtert.}, language = {de} } @article{NitzbonGadylyaevSchlueteretal.2022, author = {Nitzbon, Jan and Gadylyaev, Damir and Schl{\"u}ter, Steffen and K{\"o}hne, John Maximilian and Grosse, Guido and Boike, Julia}, title = {Brief communication: unravelling the composition and microstructure of a permafrost core using x-ray computed tomography}, series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, volume = {16}, journal = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, number = {9}, publisher = {Copernicus}, address = {Katlenburg-Lindau}, issn = {1994-0416}, doi = {10.5194/tc-16-3507-2022}, pages = {3507 -- 3515}, year = {2022}, abstract = {The microstructure of permafrost ground contains clues to its formation and hence its preconditioning to future change. We applied X-ray computed microtomography (CT) to obtain high-resolution data (Delta x = 50 mu m) of the composition of a 164 cm long permafrost core drilled in a Yedoma upland in north-eastern Siberia. The CT analysis allowed the microstructures to be directly mapped and volumetric contents of excess ice, gas inclusions, and two distinct sediment types to be quantified. Using laboratory measurements of coarsely resolved core samples, we statistically estimated the composition of the sediment types and used it to indirectly quantify volumetric contents of pore ice, organic matter, and mineral material along the core. We conclude that CT is a promising method for obtaining physical properties of permafrost cores which opens novel research potentials.}, language = {en} } @article{WangvanTurnhoutDanielsetal.2022, author = {Wang, Ningzhen and van Turnhout, Jan and Daniels, Robert and Wu, Chao and Huo, Jindong and Gerhard, Reimund and Sotzing, Gregory and Cao, Yang}, title = {Ion-boosting the charge density and piezoelectric response of ferroelectrets to significantly high levels}, series = {ACS applied materials \& interfaces}, volume = {14}, journal = {ACS applied materials \& interfaces}, number = {37}, publisher = {American Chemical Society}, address = {Washington, DC}, issn = {1944-8244}, doi = {10.1021/acsami.2c12185}, pages = {42705 -- 42712}, year = {2022}, abstract = {In contrast to molecular-dipole polymers, such as PVDF, ferroelectrets are a new class of flexible spatially heterogeneous piezoelectric polymers with dosed or open voids that act as deformable macro-dipoles after charging. With a spectrum of manufacturing processes being developed to engineer the heterogeneous structures, ferroelectrets are made with attractive piezoelectric properties well-suited for applications, such as pressure sensors, acoustic transducers, etc. However, the sources of the macro-dipole charges have usually been the same, microscopic dielectric barrier discharges within the voids, induced when the ferroelectrets are poled under a large electric field typically via a so-called corona poling, resulting in the separation and trapping of opposite charges into the interior walls of the voids. Such a process is inherently self-limiting, as the reverse internal field from the macro-dipoles eventually extinguishes the microdischarges, resulting in limited density of ions and not too high overall piezoelectric performance. Here, a new method to form ferroelectrets with gigantic electroactivity is proposed and demonstrated with the aid of an external ion booster. A laminate consisting of expanded polytetrafluoroethylene (ePTFE) and fluorinated-ethylene-propylene (FEP) was prefilled with bipolar ions produced externally by an ionizer and sequentially poled to force the separation of positive and negative ions into the open fibrous structure, rendering an impressive piezoelectric d(33)( )coefficient of 1600 pC/N-an improvement by a factor of 4 in comparison with the d(33) of a similar sandwich poled with nonenhanced corona poling. The (pre)filling dearly increases the ion density in the open voids significantly. The charges stored in the open-cell structure stays at a high level for at least 4 months. In addition, an all-organic nanogenerator was made from an ePTFE-based ferroelectret, with conducting poly(3,4-ethylene dioxythiophene): poly(styrenesulfonate) (PEDOT: PSS) coated fabric electrodes. When poled with this ion-boosting process, it yielded an output power twice that of a similar sample poled in a conventional corona-only process. The doubling in output power is mainly brought about by the significantly higher charge density achieved with the aid of external booster. Furthermore, aside from the bipolar ions, extra monopolar ions can during the corona poling be blown into the open pores by using for instance a negative ionic hair dryer to produce a unipolar ePTFE-based ferroelectret with its d(33) coefficient enhanced by a factor of 3. Ion-boosting poling thus unleashes a new route to produce bipolar or unipolar open-cell ferroelectrets with highly enhanced piezoelectric response.}, language = {en} } @article{SteinhoffWagnerTaschleretal.2022, author = {Steinhoff, Julia S. and Wagner, Carina and Taschler, Ulrike and Wulff, Sascha and Kiefer, Marie F. and Petricek, Konstantin M. and Wowro, Sylvia J. and Oster, Moritz and Flores, Roberto E. and Yang, Na and Li, Chen and Meng, Yueming and Sommerfeld, Manuela and Weger, Stefan and Henze, Andrea and Raila, Jens and Lass, Achim and Schupp, Michael}, title = {Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression}, series = {Journal of lipid research}, volume = {63}, journal = {Journal of lipid research}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-2275}, doi = {10.1016/j.jlr.2022.100268}, pages = {11}, year = {2022}, abstract = {Hepatocytes secrete retinol-binding pro-tein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in the blood. However, in a previous study, we observed that chronically increased RBP4 by forced Rbp4 expres-sion in the liver does not impair glucose homeostasis in mice. Here, we investigated the effects of an acute mobilization of hepatic vitamin A stores by hepatic overexpression of RBP4 in mice. We show that he-patic retinol mobilization decreases body fat content and enhances fat turnover. Mechanistically, we found that acute retinol mobilization increases hepatic expression and serum levels of fibroblast growth factor 21 (FGF21), which is regulated by retinol mobilization and retinoic acid in primary hepato-cytes. Moreover, we provide evidence that the insulin-sensitizing effect of FGF21 is associated with organ-specific adaptations in retinoid homeostasis. Taken together, our findings identify a novel cross-talk between retinoid homeostasis and FGF21 in mice with acute RBP4-mediated retinol mobilization from the liver.}, language = {en} } @article{MetzlerRajyaguruBerkowitz2022, author = {Metzler, Ralf and Rajyaguru, Ashish and Berkowitz, Brian}, title = {Modelling anomalous diffusion in semi-infinite disordered systems and porous media}, series = {New journal of physics : the open-access journal for physics}, volume = {24}, journal = {New journal of physics : the open-access journal for physics}, number = {12}, publisher = {IOP Publ. Ltd.}, address = {London}, issn = {1367-2630}, doi = {10.1088/1367-2630/aca70c}, pages = {12}, year = {2022}, abstract = {For an effectively one-dimensional, semi-infinite disordered system connected to a reservoir of tracer particles kept at constant concentration, we provide the dynamics of the concentration profile. Technically, we start with the Montroll-Weiss equation of a continuous time random walk with a scale-free waiting time density. From this we pass to a formulation in terms of the fractional diffusion equation for the concentration profile C(x, t) in a semi-infinite space for the boundary condition C(0, t) = C-0, using a subordination approach. From this we deduce the tracer flux and the so-called breakthrough curve (BTC) at a given distance from the tracer source. In particular, BTCs are routinely measured in geophysical contexts but are also of interest in single-particle tracking experiments. For the "residual' BTCs, given by 1- P(x, t), we demonstrate a long-time power-law behaviour that can be compared conveniently to experimental measurements. For completeness we also derive expressions for the moments in this constant-concentration boundary condition.}, language = {en} } @phdthesis{Satanowski2024, author = {Satanowski, Jerome Ari}, title = {Design and in vivo implementation of metabolic modules for synthetic carbon fixation}, school = {Universit{\"a}t Potsdam}, pages = {151}, year = {2024}, abstract = {Climate change, driven by increasing atmospheric levels of carbon dioxide (CO2), presents a significant societal challenge for the 21st century. Biotechnological approaches for microbial production of commodity chemicals and fuels offer possible solutions to re-fix CO2 from the atmosphere, thereby mitigating carbon emissions and contributing to a sustainable carbon-economy in the future. Biological CO2 fixation is also at the heart of agricultural productivity, where photosynthesis and the Calvin-Benson-Bassham cycle present promising biotechnological targets for crop improvement. Synthetic biology allows testing metabolic solutions not known to exist in nature, which may exceed their natural counterparts in terms of efficiency. In this thesis, I explore the design of such new-to-nature metabolic pathways for biological CO2 utilization and their implementation in living cells (in vivo). In the first chapter, I describe the development of a metabolic pathway that enables intracellular conversion of CO2 to formate, giving access to highly efficient carbon fixation routes. In nature, CO2-reduction remains restricted to anaerobic organisms and low redox potentials. Here, we introduce the "CORE cycle", a synthetic metabolic pathway that converts CO2 to formate under fully aerobic conditions and ambient CO2 levels, using only NADPH as a reductant. We leverage this synthetic, ATP-energized pathway to overcome the thermodynamic and kinetic barriers associated with CO2-reduction. Applying rational metabolic engineering and adaptive evolution, this work demonstrates that Escherichia coli can utilize ambient CO2 as the sole source of one-carbon units and serine, achieving a first step towards novel modes of synthetic autotrophy. We further apply computational modeling to showcase the potential of the CORE cycle as a photorespiratory bypass for enhancing photosynthesis. In the second chapter, I describe the development of the "LCM module", a novel metabolic route for CO2-incorporating conversion of acetyl-CoA to pyruvate. This route relies on the newly uncovered, promiscuous activity of an adenosylcobalamin (B12)-dependent enzyme, which we significantly optimize through targeted hypermutation and in vivo selection strategies. The LCM module provides a shorter and more efficient pathway for acetyl-CoA assimilation compared to natural routes, offering novel opportunities for synthetic CO2 fixation. Overall, through theoretical pathway analysis, enzyme bioprospecting, and modular metabolic engineering in E. coli, this thesis expands the solution space for biological CO2 fixation.}, language = {en} } @article{WoernerBeckerKuechemannetal.2022, author = {W{\"o}rner, Salome and Becker, Sebastian and K{\"u}chemann, Stefan and Scheiter, Katharina and Kuhn, Jochen}, title = {Development and validation of the ray optics in converging lenses concept inventory}, series = {Physical Review Physics Education Research (PRPECZ)}, volume = {18}, journal = {Physical Review Physics Education Research (PRPECZ)}, number = {2}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9896}, doi = {10.1103/PhysRevPhysEducRes.18.020131}, pages = {22}, year = {2022}, abstract = {Optics is a core field in the curricula of secondary physics education. In this study, we present the development and validation of a test instrument in the field of optics, the ray optics in converging lenses concept inventory (ROC-CI). It was developed for and validated with middle school students, but can also be adapted for the use in higher levels of physics education. The ROC-CI can be used as a formative or a summative assessment of students' conceptual understanding of image formation by converging lenses, assessing the following: (i) the overall understanding of fundamental concepts related to converging lenses, (ii) the understanding of specific concepts, and (iii) students' propensity for difficulties within this topic. The initial ROC-CI consists of 16 multiple-choice items; however, one item was removed based on various quality checks. We validated the ROC-CI thoroughly with distractor analyses, classical test theory, item response theory, structural analyses, and analyses of students' total scores at different measurement points as quantitative approaches, as well as student interviews and an expert survey as qualitative approaches. The quantitative analyses are mostly based on a dataset of N 1/4 318 middle school students who took the ROC-CI as a post-test. The student interviews were conducted with seven middle school students after they were taught the concepts of converging lenses. The expert survey included five experts who evaluated both individual items and the test as a whole. The analyses showed good to excellent results for the test instrument, corroborating the 15-item ROC-CI's validity and its compliance with the three foci outlined above.}, language = {en} } @phdthesis{Lagarde2024, author = {Lagarde, Sophie}, title = {Seismic imprint of natural and anthropogenic processes on the Earth surface}, doi = {10.25932/publishup-64913}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-649136}, school = {Universit{\"a}t Potsdam}, pages = {172}, year = {2024}, abstract = {Terrestrial landscape dynamics are dominated by the production, mobilisation, transfer and deposition of sediment. Numerous chemical elements are carried by sediments, making them a key component for ecological processes, as soil constitution and thus plants and animal ecosystems depends on them, and by extension the human species. They are also essential for climate evolution and regulation as marine sedimentation acts as a carbon sink. However, the processes at the origin of their production, mobilisation, transfer can occur suddenly with high-energy content - such as volcanic eruption, mass wasting or flooding events and wildfires - shaking ecosystems and shaping landforms. Besides, in the last era, the human species has shown its ability to disturb landscape dynamics and change sediments cycles. Thus, there is a need for predictive understanding of the processes involved. This relies on un-derstanding of the mechanisms of key processes and their controls, and knowledge of the state and evolution of the Earth's surface. Classic approaches to these challenges include empirical observations and numerical modeling of geochemical fluxes and surface processes, as well as the study of terrestrial sedimentary archives to better understand the parameters at stake in landscape dynamics and climate changes and the different actions and retroactions between the production, mobilisation, transfer and deposition of sediments which ultimately shape landscapes. Environmental seismology complements these approaches. Environmental seismology is the science topic investigating the source functions and propagation properties of seismic vibrations triggered by processes happening at or near the Earth's surface, below and above it - cryosphere, hydrosphere, atmosphere, human habitat, biosphere, etc., to obtain insight into all these physical processes. Indeed, from mass wasting event to rivers, from wild species to hu-man, all these processes are generating seismic waves. Environmental seismology is a rather recent field, with new branches rapidly expanding and at various stages of scientific progress. This thesis is motivated by the goal of learning more on two major natural process hazards (river bedload transport and mass wasting) as well as on human-generated acoustic hazard, while covering the axis of funda-mental research progression, from data exploration and method and theory development to proof of concept, with the twin aims of developing a better understanding of the operation of these specific processes, and of advancing the methods we have at our disposal to study them. First, I provide a benchmark for assessment of the reliability of existing seismic bedload model inver-sion to retrieve bedload flux from seismic data. Bedload flux measurements are essential to better understand river dynamics, and this can be achieved with environmental seismology. However, due to a lack of well-constrained validation data, the accuracy of the resulting inversions is unknown. I address this gap in Chapter 2.2, reporting a seismic field experiment, and comparing the results to high-quality independent bedload measurements to constrain a seismic bedload model. The study shows that the quality of bedload flux estimates from seismic data strongly depends on the quality of the input data for the model. Direct measurements of relevant parameters, chiefly seismic ground proper-ties needed for the Green's function and the grain size distribution of the moving bedload, considerably improve the model quality over generic approaches using empirical or theoretical functions. I also pro-vide a numerical tool to facilitate the use of water turbulence and bedload seismic inversion models: seismic models for bedload flux and water turbulence require painstaking work to constrain parame-ters describing the ground properties by active seismic study or analysis of passive seismic data, and the grain size distribution via independent measurements. Reasonable predictions can be achieved by using a Monte Carlo approach to optimize the free parameters with respect to the target parameters. The validation of the tool, in Chapter 2.3, with independent measurements of water depth and bedload flux at a study site on the Eshtemoa river in Isra{\"e}l makes it available for reliable use at other sites. The work reported in this chapter has been published in Lagarde et al. 2021 and Dietze et al. 2019b. In a second study, reported in Chapter 3, I investigate the formation of a failure plane prior to a rock-slide. A better understanding of the dynamics of the preparation phase is essential to determine the timing, volume and mobilization mechanism of a rock slope failure, and this can be achieved with envi-ronmental seismology. I take advantage of a network of seismic stations close to an instable slope recording cracking signals prior to the slope failure, and use a machine learning technique based on hidden Markov models to isolate these signals from the seismic data, retrieving the cumulative number of cracking events in a period of 20 days prior to a large rockslide and 10 days after. The trajectory of the cumulative number of cracks shifts from a rather linear shape in the two weeks prior to the rock-slide to an S-shaped development in the last 27 h before failure. I interpret this change as a switch from initial distributed cracking to localised damage accumulation in the hours prior to the failure. I develop a simple physical model to explain the temporal evolution of crack activity during the S-shape phase, revealing the importance of an internal parameter, the total crack boundary length as the dominant control parameter of failure plane evolution. This study has been published as Lagarde et al. 2023. Third, I develop a model converting acoustic signals to seismic signals. A part of the acoustic vibrations generated on the Earth's surface is converted to seismic signals at the ground interface. Consequently, noise pollution may be translated to slope fatigue and rock micro (or macro) fracturing resulting in a degrading effect on landforms. Moreover, this pollution can have negative impacts, such as physical, physiological as well as psychological effects on animal species. At present, the impact of seismic pol-lution generated by acoustic sources is difficult to evaluate. In Chapter 4, I improve and implement a model converting the acoustic pressure generated by a source in the atmosphere to the corresponding seismic signal for a receiver within the ground. The ground is considered to be a porous elastic medium in which wave behaviour can be approximated by the Biot-Stoll model. The model is extended for use of a temporal pressure pulse as an input, and to produce output on a plan 2D map, where the wind effect on the acoustic to seismic coupling can be reproduced. I invest extensive effort in making the model user-friendly, as the project aims at reaching a large audience, comprising, for example, geo-morphologists, biologists and sociologists. Finally, the model is subjected to synthetic testing as well as a qualitative comparison of the predicted ground particle velocity and the seismic signal of a real heli-copter flight as a source of acoustic input. These studies advance understanding of the operation of specific natural processes in channels and on hillslopes, and bring us closer to designing functioning early warning systems for mass-wasting and flood events. This thesis also raises questions that have not been considered before, such as the con-tribution of human acoustic pollution to the seismic hum and its impact on the natural environment, or the importance of cracks in the self-development of the failure plane prior to slope. Together, these studies question general assumptions usually made regarding the triggering of mass wasting or the hillslope-channel connectivity. Beyond this, the thesis covers the axis of fundamental research progres-sion, from data exploration and method and theory development to proof of concept, and shows how in the rapidly developing field of environmental seismology, an active awareness of progress can help strengthen and accelerate general advances.}, language = {en} } @article{PicozziBindiFestaetal.2021, author = {Picozzi, Matteo and Bindi, Dino and Festa, Gaetano and Cotton, Fabrice Pierre and Scala, Antonio and D'Agostino, Nicola}, title = {Spatiotemporal evolution of microseismicity seismic source properties at the Irpinia Near-Fault Observatory, Southern Italy}, series = {Bulletin of the Seismological Society of America}, volume = {112}, journal = {Bulletin of the Seismological Society of America}, number = {1}, publisher = {Seismological Society of America}, address = {El Cerito, Calif.}, issn = {0037-1106}, doi = {10.1785/0120210064}, pages = {226 -- 242}, year = {2021}, abstract = {We estimate the source parameters of small-magnitude earthquakes that occurred during 2008-2020 in the Irpinia faults area (southern Italy). We apply a spectral decomposition approach to isolate the source contribution from propagation and site effects for similar to 3000 earthquakes in the local magnitude range between M-L 0 and 4.2. We develop our analyses in three steps. First, we fit the Brune (1970) model to the nonparametric source spectra to estimate corner frequency and seismic moment, and we map the spatial distribution of stress drop across the Irpinia area. We found stress drops in the range 0.4-8.1 MPa, with earthquakes deeper than 7 km characterized by higher average stress drop (i.e., 3.2 MPa). Second, assuming a simple stress-release model (kanamori and Heaton, 2000), we derive fracture energy and critical slip-weakening distance. The spatial variability of stress drop and fracture energy allows us to image the present stress conditions of fault segments activated during the 23 November 1980 M-s 6.9 earthquake. The variability of the source parameters shows clear patterns of the fault mechanical properties, suggesting that the Irpinia fault system can be divided into three main sectors, with the northern and southern ones showing different properties from the central one. Our results agree with previous studies indicating the presence of fluids with different composition in the different sectors of the Irpinia fault system. In the third step, we compare the time evolution of source parameters with a time series of geodetic displacement recorded near the fault system. Temporal trends in the correlation between geodetic displacement and different source parameters indicate that the poroelastic deformation perturbation generated by the karst aquifer recharge is modulating not only the occurrence rate of micro-seismicity ( D' Agostino et al., 2018) but may lead to rupture asperities with different sizes and characteristics.}, language = {en} } @article{EickenscheidtLavauxPaschkeetal.2022, author = {Eickenscheidt, Alice and Lavaux, Valentine and Paschke, Stefan and Martinez Guajardo, Alejandro and Sch{\"o}nemann, Eric and Laschewsky, Andre and Lienkamp, Karen and Staszewski, Ori}, title = {Effect of poly(oxanorbonene)- and poly(methacrylate)-based polyzwitterionic surface coatings on cell adhesion and gene expression of human keratinocytes}, series = {Macromolecular bioscience}, volume = {22}, journal = {Macromolecular bioscience}, number = {11}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1616-5187}, doi = {10.1002/mabi.202200225}, pages = {16}, year = {2022}, abstract = {Polyzwitterions are generally known for their anti-adhesive properties, including resistance to protein and cell adhesion, and overall high bio-inertness. Yet there are a few polyzwitterions to which mammalian cells do adhere. To understand the structural features of this behavior, a panel of polyzwitterions with different functional groups and overall degrees of hydrophobicity is analyzed here, and their physical and biological properties are correlated to these structural differences. Cell adhesion is focused on, which is the basic requirement for cell viability, proliferation, and growth. With the here presented polyzwitterion panel, three different types of cell-surface interactions are observed: adhesion, slight attachment, and cell repellency. Using immunofluorescence methods, it is found that human keratinocytes (HaCaT) form focal adhesions on the cell-adhesive polyzwitterions, but not on the sample that has only slight cell attachment. Gene expression analysis indicates that HaCaT cells cultivated in the presence of a non-adhesive polyzwitterion have up-regulated inflammatory and apoptosis-related cell signaling pathways, while the gene expression of HaCaT cells grown on a cell-adhesive polyzwitterion does not differ from the gene expression of the growth control, and thus can be defined as fully cell-compatible.}, language = {en} } @misc{HackmannWolff2023, author = {Hackmann, Nina and Wolff, Christina}, title = {Einleitung: Diskursive Auseinandersetzung mit Zweigeschlechtlichkeit und die hochschulpolitische Ausgangslage}, doi = {10.25932/publishup-60131}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-601311}, pages = {10}, year = {2023}, language = {de} } @misc{EbersHochRosenkranzetal.2021, author = {Ebers, Martin and Hoch, Veronica R. S. and Rosenkranz, Frank and Ruschemeier, Hannah and Steinr{\"o}tter, Bj{\"o}rn}, title = {The European Commission's proposal for an Artificial Intelligence Act}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, number = {8}, doi = {10.25932/publishup-59682}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-596824}, pages = {16}, year = {2021}, abstract = {On 21 April 2021, the European Commission presented its long-awaited proposal for a Regulation "laying down harmonized rules on Artificial Intelligence", the so-called "Artificial Intelligence Act" (AIA). This article takes a critical look at the proposed regulation. After an introduction (1), the paper analyzes the unclear preemptive effect of the AIA and EU competences (2), the scope of application (3), the prohibited uses of Artificial Intelligence (AI) (4), the provisions on high-risk AI systems (5), the obligations of providers and users (6), the requirements for AI systems with limited risks (7), the enforcement system (8), the relationship of the AIA with the existing legal framework (9), and the regulatory gaps (10). The last section draws some final conclusions (11).}, language = {en} } @misc{Bilgen2023, author = {Bilgen, Isa}, title = {Freiheit und Nachhaltigkeit im Verfassungswandel}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, number = {9}, issn = {2366-7044}, doi = {10.25932/publishup-60008}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-600084}, pages = {8}, year = {2023}, abstract = {Mit dem Klima wandelt sich auch notwendig die offene Gesellschaft. Und mit ihr wandelt sich wiederum auch die Verfassung(-sinterpretation). Periodisch wiederkehrende Gesundheits- und Sicherheitskrisen fordern eine dynamische Reaktion des Grundgesetzes auf mit ihnen einhergehende Probleme. In andauernden Krisen wie der Umweltkrise muss die Verfassung gleichzeitig in vielerlei Hinsicht nachhaltig sein. Dabei muss das, was wir unter Freiheit, Klima‑, Umwelt- oder Tierschutz verstehen, immer im Wandel bleiben.}, language = {de} } @misc{GonzalezHauckHerrmannHettihewaetal.2022, author = {Gonz{\´a}lez Hauck, Su{\´e} and Herrmann, Franziska M. and Hettihewa, Julian A. and Kraft, Dariush and Milas, Max and Springer, Stephanie and Weckner, Franka}, title = {Jurisdiction}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, number = {11}, doi = {10.25932/publishup-60213}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-602139}, pages = {12}, year = {2022}, language = {en} } @misc{Lemke2021, author = {Lemke, Tristan}, title = {Keine Reform f{\"u}r die Zukunft}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Rechtswissenschaftliche Reihe}, number = {13}, doi = {10.25932/publishup-60375}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-603750}, pages = {6}, year = {2021}, abstract = {Am 1. Januar 2021 trat die j{\"u}ngste Reform des Erneuerbare-Energien-Gesetzes (EEG) in Kraft. Sie f{\"u}hrte mit der finanziellen Beteiligung der Gemeinden an den Ertr{\"a}gen der Windenergie klammheimlich eine verfassungswidrige Abgabe ein: Durch das Zusammenspiel des neuen \S 36k EEG 2021 mit der altbekannten EEG-Umlage fließt eine bei den Strom-Endverbrauchern erhobene Abgabe in die kommunalen Haushalte. Das kann auf keine Gesetzgebungskompetenz gest{\"u}tzt werden. Dar{\"u}ber hinaus f{\"u}hrt die Deckelung der EEG-Umlage in den Jahren 2021 und 2022 in Verbindung mit \S 36k EEG 2021 dazu, dass in verfassungswidriger Weise Bundesmittel den Gemeinden zur freien Verf{\"u}gung gestellt werden.}, language = {de} } @misc{SeyfriedReith2020, author = {Seyfried, Markus and Reith, Florian}, title = {Strength of weakness}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {163}, issn = {1867-5808}, doi = {10.25932/publishup-54097}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-540972}, pages = {18}, year = {2020}, abstract = {The paper investigates quality management in teaching and learning in higher education institutions from a principal-agent perspective. Based on data gained from semi-structured interviews and from a nation-wide survey with quality managers of German higher education institutions, the study shows how quality managers position themselves in relation to their perception of the interests of other actors in higher education institutions. The paper describes the various interests and discusses the main implications of this constellation of actors. It argues that quality managers, although they may be considered as rather weak actors within the higher education institution, may be characterised as having a strength of weakness due to diverging interests of their principals.}, language = {en} } @misc{FischerPresslerMarxBunkeretal.2023, author = {Fischer-Preßler, Diana and Marx, Julian and Bunker, Deborah and Stieglitz, Stefan and Fischbach, Kai}, title = {Social media information governance in multi-level organizations}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {185}, issn = {1867-5808}, doi = {10.25932/publishup-60840}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-608409}, pages = {20}, year = {2023}, abstract = {Strategic social media use positively influences organizational goals such as the long-term accrual of social capital, and thus social media information governance has become an increasingly important organizational objective. It is particularly important for humanitarian nongovernmental organizations (HNGOs), whose work relies on accurate and timely information regarding socially altruistic behavior (donations, volunteerism, etc.). Despite the potential of social media for increasing social capital, tensions in governing social media information across an organization's different operational levels (regional, intermediate, and national) pose a difficult challenge. Prominent governance frameworks offer little guidance, as their focus on control and incremental policymaking is largely incompatible with the processes, roles, standards, and metrics needed for managing self-governing social media. This study offers a notion of dynamic and co-evolutionary process management of multi-level organizations as a means of conceptualizing social media information governance for the accrual of organizational social capital. Based on interviews with members of HNGOs, this study reveals tensions that emerge within eight focus areas of accruing social capital in multi-level organizations, explains how dynamic process management can ease those tensions, and proposes corresponding strategy recommendations.}, language = {en} } @article{HoefsHuelagueBennetetal.2021, author = {H{\"o}fs, Soraya and Huelague, Deniz and Bennet, Francesca and Carl, Peter and Flemig, Sabine and Schmid, Thomas and Schenk, Jorg A. and Hodoroaba, Vasile-Dan and Schneider, Rudolf J.}, title = {Electrochemical immunomagnetic Ochratoxin A sensing}, series = {ChemElectroChem}, volume = {8}, journal = {ChemElectroChem}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {2196-0216}, doi = {10.1002/celc.202100446}, pages = {2597 -- 2606}, year = {2021}, abstract = {Electrochemical methods offer great promise in meeting the demand for user-friendly on-site devices for monitoring important parameters. The food industry often runs own lab procedures, for example, for mycotoxin analysis, but it is a major goal to simplify analysis, linking analytical methods with smart technologies. Enzyme-linked immunosorbent assays, with photometric detection of 3,3',5,5'-tetramethylbenzidine (TMB), form a good basis for sensitive detection. To provide a straightforward approach for the miniaturization of the detection step, we have studied the pitfalls of the electrochemical TMB detection. By cyclic voltammetry it was found that the TMB electrochemistry is strongly dependent on the pH and the electrode material. A stable electrode response to TMB could be achieved at pH 1 on gold electrodes. We created a smartphone-based, electrochemical, immunomagnetic assay for the detection of ochratoxin A in real samples, providing a solid basis for sensing of further analytes.}, language = {en} } @misc{GonnermannBrandenburgerVladovaetal.2023, author = {Gonnermann, Jana and Brandenburger, Bonny and Vladova, Gergana and Gronau, Norbert}, title = {To what extent can individualisation in terms of different types of mode improve learning outcomes and learner satisfaction?}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {193}, editor = {Bui, Tung X.}, issn = {1867-5808}, doi = {10.25932/publishup-60475}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-604759}, pages = {12}, year = {2023}, abstract = {With the latest technological developments and associated new possibilities in teaching, the personalisation of learning is gaining more and more importance. It assumes that individual learning experiences and results could generally be improved when personal learning preferences are considered. To do justice to the complexity of the personalisation possibilities of teaching and learning processes, we illustrate the components of learning and teaching in the digital environment and their interdependencies in an initial model. Furthermore, in a pre-study, we investigate the relationships between the learner's ability to (digital) self-organise, the learner's prior- knowledge learning in different variants of mode and learning outcomes as one part of this model. With this pre-study, we are taking the first step towards a holistic model of teaching and learning in digital environments.}, language = {en} } @article{PanLiuGouetal.2021, author = {Pan, Hanya and Liu, Rui and Gou, Tingyu and Kliem, Bernhard and Su, Yingna and Chen, Jun and Wang, Yuming}, title = {Pre-eruption splitting of the double-decker structure in a solar filament}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {909}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {Institute of Physics Publ.}, address = {London}, issn = {0004-637X}, doi = {10.3847/1538-4357/abda4e}, pages = {12}, year = {2021}, abstract = {Solar filaments often erupt partially. Although how they split remains elusive, the splitting process has the potential of revealing the filament structure and eruption mechanism. Here we investigate the pre-eruption splitting of an apparently single filament and its subsequent partial eruption on 2012 September 27. The evolution is characterized by three stages with distinct dynamics. During the quasi-static stage, the splitting proceeds gradually for about 1.5 hr, with the upper branch rising at a few kilometers per second and displaying swirling motions about its axis. During the precursor stage that lasts for about 10 minutes, the upper branch rises at tens of kilometers per second, with a pair of conjugated dimming regions starting to develop at its footpoints; with the swirling motions turning chaotic, the axis of the upper branch whips southward, which drives an arc-shaped extreme-ultraviolet front propagating in a similar direction. During the eruption stage, the upper branch erupts with the onset of a C3.7-class two-ribbon flare, while the lower branch remains stable. Judging from the well-separated footpoints of the upper branch from those of the lower one, we suggest that the pre-eruption filament processes a double-decker structure composed of two distinct flux bundles, whose formation is associated with gradual magnetic flux cancellations and converging photospheric flows around the polarity inversion line.}, language = {en} } @incollection{Homolka2024, author = {Homolka, Walter}, title = {Christology and the biographical Jesus}, series = {Zur Gegenwart des kommenden Gottes - Anst{\"o}ße aus der Erfahrung suchenden Theologie von Tiemo Rainer Peters}, booktitle = {Zur Gegenwart des kommenden Gottes - Anst{\"o}ße aus der Erfahrung suchenden Theologie von Tiemo Rainer Peters}, publisher = {Matthias Gr{\"u}newald Verlag}, address = {Ostfildern}, isbn = {978-3-7867-3323-2}, pages = {377 -- 398}, year = {2024}, language = {en} } @article{Homolka2021, author = {Homolka, Walter}, title = {Glaubensfragen}, series = {{\"U}ber Grenzen hinweg zu neuer Gemeinschaft - Bilanz und Perspektiven des christlich-j{\"u}dischen Gespr{\"a}chs (Reihe: Forum Christen und Juden/Forum for Christians and Jews)}, volume = {23}, journal = {{\"U}ber Grenzen hinweg zu neuer Gemeinschaft - Bilanz und Perspektiven des christlich-j{\"u}dischen Gespr{\"a}chs (Reihe: Forum Christen und Juden/Forum for Christians and Jews)}, publisher = {LIT}, address = {Berlin, M{\"u}nster}, isbn = {978-3-643-15083-7}, pages = {247 -- 260}, year = {2021}, abstract = {Der Artikel gibt einen {\"U}berblick {\"u}ber die verschiedenen Phasen von siebzig Jahren christlich-j{\"u}discher Dialog und blickt in die Zukunft. Akzeptieren Christen die Konsequenzen, die aus der Immanenz des Judentums in ihrer Religion folgen? Vor allem in zentralen Handlungsfeldern der systematischen Theologie bleibt viel Raum f{\"u}r Entwicklung, allen voran der Christologie.}, language = {de} } @article{TellaWinterleitnerMorsillietal.2022, author = {Tella, Timothy O. and Winterleitner, Gerd and Morsilli, Michele and Mutti, Maria}, title = {Testing sea-level and carbonate production effects on stratal architecture of a distally steepened carbonate ramp (Upper Miocene, Menorca)}, series = {Sedimentary geology : international journal of applied and regional sedimentology}, volume = {441}, journal = {Sedimentary geology : international journal of applied and regional sedimentology}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, issn = {0037-0738}, doi = {10.1016/j.sedgeo.2022.106267}, pages = {18}, year = {2022}, abstract = {Although distally steepened carbonate ramps have been studied by numerous researchers, the processes that control the development of these carbonate systems, including tectonics, differential carbonate production along the ramp profile, or antecedent physiography of the slopes, are an ongoing discussion. We use a stratigraphic forward model to test different hypotheses to unravel controls over distally steepened ramp development, referenced to the well-known Upper Miocene Menorca carbonate ramp (Spain). Sensitivity tests show that distally steepened ramps develop under complex interaction among accommodation, carbonate production and sediment transport parameters. Ramp slope initiation is favoured by still stands and falls of sea-level, in a setting with high-frequency sea-level fluctuations with amplitude between 20 m and 40 m. Low-frequency and higher amplitude sea-level fluctuations of about 115 m tend to form models with no significant slope development. The impact of antecedent slope on the geometry of ramps is determined by the paleoslope inclination, with flat to subhorizontal paleosurfaces resulting in ramps that mirror the antecedent slope. In contrast, steeper paleosurfaces tend to result in ramps with well-defined slopes. Our models, therefore, show that the ramp profile becomes more influenced by the depth constraints on the carbonate sediment producers than by the geometry of the underlying topography as the inclination of the paleosurface increases. The presented models also show that seagrass-dominated shallow carbonate production tends to result in steep slopes due to the low-transport characteristic imposed by seagrass trapping. This steepness can, however, be altered by the introduction of high transport sediment grains from deeper carbonate producers, which fill the slopes and more distal sections of the ramp profile.}, language = {en} } @article{BehmAlizadehHadjizedahAnvaretal.2021, author = {Behm, David G. and Alizadeh, Shahab and Hadjizedah Anvar, Saman and Hanlon, Courtney and Ramsay, Emma and Mahmoud, Mohamed Mamdouh Ibrahim and Whitten, Joseph and Fisher, James P. and Prieske, Olaf and Chaabene, Helmi and Granacher, Urs and Steele, James}, title = {Non-local muscle fatigue effects on muscle strength, power, and endurance in healthy individuals}, series = {Sports medicine : the world's premier sports medicine preview journal}, volume = {51}, journal = {Sports medicine : the world's premier sports medicine preview journal}, number = {9}, publisher = {Springer}, address = {Berlin [u.a.]}, issn = {0112-1642}, doi = {10.1007/s40279-021-01456-3}, pages = {1893 -- 1907}, year = {2021}, abstract = {Background The fatigue of a muscle or muscle group can produce global responses to a variety of systems (i.e., cardiovascular, endocrine, and others). There are also reported strength and endurance impairments of non-exercised muscles following the fatigue of another muscle; however, the literature is inconsistent. Objective To examine whether non-local muscle fatigue (NLMF) occurs following the performance of a fatiguing bout of exercise of a different muscle(s). Design Systematic review and meta-analysis. Search and Inclusion A systematic literature search using a Boolean search strategy was conducted with PubMed, SPORTDiscus, Web of Science, and Google Scholar in April 2020, and was supplemented with additional 'snowballing' searches up to September 2020. To be included in our analysis, studies had to include at least one intentional performance measure (i.e., strength, endurance, or power), which if reduced could be considered evidence of muscle fatigue, and also had to include the implementation of a fatiguing protocol to a location (i.e., limb or limbs) that differed to those for which performance was measured. We excluded studies that measured only mechanistic variables such as electromyographic activity, or spinal/supraspinal excitability. After search and screening, 52 studies were eligible for inclusion including 57 groups of participants (median sample = 11) and a total of 303 participants. Results The main multilevel meta-analysis model including all effects sizes (278 across 50 clusters [median = 4, range = 1 to 18 effects per cluster) revealed a trivial point estimate with high precision for the interval estimate [- 0.02 (95\% CIs = - 0.14 to 0.09)], yet with substantial heterogeneity (Q((277)) = 642.3, p < 0.01), I-2 = 67.4\%). Subgroup and meta-regression analyses showed that NLMF effects were not moderated by study design (between vs. within-participant), homologous vs. heterologous effects, upper or lower body effects, participant training status, sex, age, the time of post-fatigue protocol measurement, or the severity of the fatigue protocol. However, there did appear to be an effect of type of outcome measure where both strength [0.11 (95\% CIs = 0.01-0.21)] and power outcomes had trivial effects [- 0.01 (95\% CIs = - 0.24 to 0.22)], whereas endurance outcomes showed moderate albeit imprecise effects [- 0.54 (95\% CIs = - 0.95 to - 0.14)]. Conclusions Overall, the findings do not support the existence of a general NLMF effect; however, when examining specific types of performance outcomes, there may be an effect specifically upon endurance-based outcomes (i.e., time to task failure). However, there are relatively fewer studies that have examined endurance effects or mechanisms explaining this possible effect, in addition to fewer studies including women or younger and older participants, and considering causal effects of prior training history through the use of longitudinal intervention study designs. Thus, it seems pertinent that future research on NLMF effects should be redirected towards these still relatively unexplored areas.}, language = {en} } @article{RonkainenPesolaTikkanenetal.2021, author = {Ronkainen, Noora J. and Pesola, Arto J. and Tikkanen, Olli and Brand, Ralf}, title = {Continuity and discontinuity of sport and exercise type during the COVID-19 pandemic}, series = {Frontiers in psychology}, volume = {12}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2021.622876}, pages = {10}, year = {2021}, abstract = {Involvement in sport and exercise not only provides participants with health benefits but can be an important aspect of living a meaningful life. The COVID-19 pandemic and the temporary cessation of public life in March/April/May 2020 came with restrictions, which probably also made it difficult, if not impossible, to participate in certain types of sport or exercise. Following the philosophical position that different types of sport and exercise offer different ways of "relating to the world," this study explored (dis)continuity in the type of sport and exercise people practiced during the pandemic-related lockdown, and possible effects on mood. Data from a survey of 601 adult exercisers, collected shortly after the COVID-19 outbreak in Finland, were analyzed. Approximately one third (35\%) of the participants changed their "worldmaking" and shifted to "I-Nature"-type activities. We observed worse mood during the pandemic in those who shifted from "I-Me," compared to those who had preferred the "I-Nature" relation already before the pandemic and thus experienced continuity. The clouded mood of those experiencing discontinuity may be the result of a temporary loss of "feeling at home" in their new exercise life-world. However, further empirical investigation must follow, because the observed effect sizes were small.}, language = {en} } @article{RazaghiMoghadamSokolowskaSowaetal.2021, author = {Razaghi-Moghadam, Zahra and Sokolowska, Ewelina and Sowa, Marcin A. and Skirycz, Aleksandra and Nikoloski, Zoran}, title = {Combination of network and molecule structure accurately predicts competitive inhibitory interactions}, series = {Computational and structural biotechnology journal}, volume = {19}, journal = {Computational and structural biotechnology journal}, publisher = {Research Network of Computational and Structural Biotechnology (RNCSB)}, address = {Gotenburg}, issn = {2001-0370}, doi = {10.1016/j.csbj.2021.04.012}, pages = {2170 -- 2178}, year = {2021}, abstract = {Mining of metabolite-protein interaction networks facilitates the identification of design principles underlying the regulation of different cellular processes. However, identification and characterization of the regulatory role that metabolites play in interactions with proteins on a genome-scale level remains a pressing task. Based on availability of high-quality metabolite-protein interaction networks and genome-scale metabolic networks, here we propose a supervised machine learning approach, called CIRI that determines whether or not a metabolite is involved in a competitive inhibitory regulatory interaction with an enzyme. First, we show that CIRI outperforms the naive approach based on a structural similarity threshold for a putative competitive inhibitor and the substrates of a metabolic reaction. We also validate the performance of CIRI on several unseen data sets and databases of metabolite-protein interactions not used in the training, and demonstrate that the classifier can be effectively used to predict competitive inhibitory interactions. Finally, we show that CIRI can be employed to refine predictions about metabolite-protein interactions from a recently proposed PROMIS approach that employs metabolomics and proteomics profiles from size exclusion chromatography in E. coli to predict metaboliteprotein interactions. Altogether, CIRI fills a gap in cataloguing metabolite-protein interactions and can be used in directing future machine learning efforts to categorize the regulatory type of these interactions.}, language = {en} } @article{CampbellKairaliyevaSanteretal.2022, author = {Campbell, Richard and Kairaliyeva, Talmira and Santer, Svetlana and Schneck, Emanuel and Miller, Reinhard}, title = {Direct resolution of the interactions of a hydrocarbon gas with adsorbed surfactant monolayers at the water/air interface using neutron reflectometry}, series = {Colloids and interfaces}, volume = {6}, journal = {Colloids and interfaces}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2504-5377}, doi = {10.3390/colloids6040068}, pages = {12}, year = {2022}, abstract = {We have directly resolved in the present work the interfacial composition during and after the interactions of a saturated atmosphere of oil vapor with soluble surfactant solutions at a planar water/air interface for the first time. Experiments were conducted on interactions of hexane vapor with solutions of alkyltrimethylammonium bromides and sodium dodecyl sulfate to observe the balance between cooperativity and competition of the components at the interface. In all cases, hexane adsorption was strongly enhanced by the presence of the surfactant, even at bulk surfactant concentrations four orders of magnitude below the critical micelle concentration. Cooperativity of the surfactant adsorption was observed only for sodium dodecyl sulfate at intermediate bulk concentrations, yet for all four systems, competition set in at higher concentrations, as hexane adsorption reduced the surfactant surface excess. The data fully supported the complete removal of hexane from the interface following venting of the system to remove the saturated atmosphere of oil vapor. These results help to identify future experiments that would elaborate and could explain the cooperativity of surfactant adsorption, such as on cationic surfactants with short alkyl chains and a broader series of anionic surfactants. This work holds relevance for oil recovery applications with foam, where there is a gas phase saturated with oil vapor.}, language = {en} } @book{FuhrhopPeters2023, author = {Fuhrhop, Nanna and Peters, J{\"o}rg}, title = {Einf{\"u}hrung in die Phonologie und Graphematik}, edition = {2., aktualisierte und erweiterte}, publisher = {J.B. Metzler}, address = {Stuttgart}, isbn = {978-3-476-05939-0}, doi = {10.1007/978-3-476-05940-6}, pages = {IX, 315}, year = {2023}, abstract = {Phonologie, die Lehre von der lautlichen Organisation der Sprache, ist einer der zentralen Bereiche der Sprachwissenschaft. Auch das Schriftsystem, das Gegenstand der Graphematik ist, gewinnt zunehmend an Bedeutung f{\"u}r Forschung und Lehre. Dieser Band informiert {\"u}ber Form und Funktion der wichtigsten Einheiten des gesprochenen und geschriebenen Deutschen, von den Lauten und Buchstaben {\"u}ber Sprech- und Schreibsilben bis hin zu phonologischen und graphematischen W{\"o}rtern, phonologischen {\"A}ußerungen und graphematischen S{\"a}tzen. In zweifarbiger Gestaltung mit Definitionen, Beispielen, Grafiken und Aufgaben. - Die 2. Auflage wurde durchg{\"a}ngig aktualisiert und erweitert.}, language = {de} } @article{ShoghiArslanBastiaanseetal.2022, author = {Shoghi, Sara and Arslan, Seckin and Bastiaanse, Roelien and Popov, Srdan}, title = {Does a walk-through video help the parser down the garden-path?}, series = {Frontiers in psychology}, volume = {13}, journal = {Frontiers in psychology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2022.1009265}, pages = {14}, year = {2022}, abstract = {The human language processing mechanism assigns a structure to the incoming materials as they unfold. There is evidence that the parser prefers some attachment types over others; however, theories of sentence processing are still in dispute over the stage at which each source of information contributes to the parsing system. The present study aims to identify the nature of initial parsing decisions during sentence processing through manipulating attachment type and verbs' argument structure. To this end, we designed a self-paced reading task using globally ambiguous constructions in Dutch. The structures included double locative prepositional phrases (PPs) where the first PP could attach both to the verb (high attachment) and the noun preceding it (low attachment). To disambiguate the structures, we presented a visual context in the form of short animation clips prior to each reading task. Furthermore, we manipulated the argument structure of the sentences using 2- and 3-argument verbs. The results showed that parsing decisions were influenced by contextual cues depending on the argument structure of the verb. That is, the visual context overcame the preference for high attachment only in the case of 2-argument verbs, while this preference persisted in structures including 3-argument verbs as represented by longer reading times for the low attachment interpretations. These findings can be taken as evidence that our language processing system actively integrates information from linguistic and non-linguistic sources from the initial stages of analysis to build up meaning. We discuss our findings in light of serial and parallel models of sentence processing.}, language = {en} } @article{HabelSchmittGrosetal.2022, author = {Habel, Jan Christian and Schmitt, Thomas and Gros, Patrick and Ulrich, Werner}, title = {Breakpoints in butterfly decline in Central Europe over the last century}, series = {The science of the total environment : an international journal for scientific research into the environment and its relationship with man}, volume = {851}, journal = {The science of the total environment : an international journal for scientific research into the environment and its relationship with man}, number = {Part 2}, publisher = {Elsevier Science}, address = {Amsterdam}, issn = {0048-9697}, doi = {10.1016/j.scitotenv.2022.158315}, pages = {9}, year = {2022}, abstract = {Recent studies indicated severe decline of insect diversity and abundance across major parts of Central Europe. Theoretical studies showed that the drivers behind biodiversity loss vary considerably over time. However, these scenarios so far have been insufficiently approved by long-term and large-scale data. In this study we analysed the temporal trends of butterflies and Zygaenid moths across the federal state of Salzburg, northern Austria, from 1920 to 2019. Our study area covers a large variety of habitats and altitudes. Various changes of land use and intensification occurred during and shortly before our studied period, with a first wave of habitat destruction starting in the late 19th century, followed by the deterioration of habitat quality since the mid-20th century. We used 59,870 presence-only data of 168 butterfly and burnet moth species. Each of these species was classified according to ecological characteristics. Break point analyses for non-linear temporal trends in the community composition returned two major time windows. These time windows coincide with periods characterized by severe habitat destruction and the deterioration of habitat quality due to agricultural intensification. We found significant reductions of the proportion of species requiring specific habitats since 1920 and until today. We identified additional break points for species requiring high habitat qualities, endangered butterfly species, and sedentary species, particularly after a main break point in the 1960s. Our findings underline that, apart from habitat destruction, the deterioration of habitat quality is a main driver of biodiversity loss in general. Therefore, nature conservation should focus on maintaining the highest possible habitat quality.}, language = {en} } @article{GoerigkOuwensKuhnetal.2022, author = {G{\"o}rigk, Sarah and Ouwens, D. Margriet and Kuhn, Tanja and Altenhofen, Delsi and Binsch, Christian and Damen, Mareike and Khuong, Jenny Minh-An and Kaiser, Katharina and Knebel, Birgit and Vogel, Heike and Sch{\"u}rmann, Annette and Chadt, Alexandra and Al-Hasani, Hadi}, title = {Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes}, series = {Biochimica et biophysica acta : Molecular and cell biology of lipids}, volume = {1867}, journal = {Biochimica et biophysica acta : Molecular and cell biology of lipids}, number = {6}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1388-1981}, doi = {10.1016/j.bbalip.2022.159153}, pages = {12}, year = {2022}, abstract = {Changes in intracellular CoA levels are known to contribute to the development of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D) in human and rodents. However, the underlying genetic basis is still poorly understood. Due to their diverse susceptibility towards metabolic diseases, mouse inbred strains have been proven to serve as powerful tools for the identification of novel genetic factors that underlie the patho-physiology of NAFLD and diabetes. Transcriptome analysis of mouse liver samples revealed the nucleoside diphosphate linked moiety X-type motif Nudt19 as novel candidate gene responsible for NAFLD and T2D development. Knockdown (KD) of Nudt19 increased mitochondrial and glycolytic ATP production rates in Hepa 1-6 cells by 41\% and 10\%, respectively. The enforced utilization of glutamine or fatty acids as energy substrate reduced uncoupled respiration by 41\% and 47\%, respectively, in non-target (NT) siRNA transfected cells. This reduction was prevented upon Nudt19 KD. Furthermore, incubation with palmitate or oleate respectively increased mitochondrial ATP production by 31\% and 20\%, and uncoupled respiration by 23\% and 30\% in Nudt19 KD cells, but not in NT cells. The enhanced fatty acid oxidation in Nudt19 KD cells was accompanied by a 1.3-fold increased abundance of Pdk4. This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.}, language = {en} } @article{FengKochovskiArenzetal.2022, author = {Feng, Yiqing and Kochovski, Zdravko and Arenz, Christoph and Lu, Yan and Kneipp, Janina}, title = {Structure and interaction of ceramide-containing liposomes with gold nanoparticles as characterized by SERS and Cryo-EM}, series = {The journal of physical chemistry : C, Nanomaterials and interfaces}, volume = {126}, journal = {The journal of physical chemistry : C, Nanomaterials and interfaces}, number = {31}, publisher = {American Chemical Society}, address = {Washington, DC}, issn = {1932-7447}, doi = {10.1021/acs.jpcc.2c01930}, pages = {13237 -- 13246}, year = {2022}, abstract = {Due to the great potential of surface-enhanced Raman scattering (SERS) as local vibrational probe of lipid-nanostructure interaction in lipid bilayers, it is important to characterize these interactions in detail. The interpretation of SERS data of lipids in living cells requires an understanding of how the molecules interact with gold nanostructures and how intermolecular interactions influence the proximity and contact between lipids and nanoparticles. Ceramide, a sphingolipid that acts as important structural component and regulator of biological function, therefore of interest to probing, lacks a phosphocholine head group that is common to many lipids used in liposome models. SERS spectra of liposomes of a mixture of ceramide, phosphatidic acid, and phosphatidylcholine, as well as of pure ceramide and of the phospholipid mixture are reported. Distinct groups of SERS spectra represent varied contributions of the choline, sphingosine, and phosphate head groups and the structures of the acyl chains. Spectral bands related to the state of order of the membrane and moreover to the amide function of the sphingosine head groups indicate that the gold nanoparticles interact with molecules involved in different intermolecular relations. While cryogenic electron microscopy shows the formation of bilayer liposomes in all preparations, pure ceramide was found to also form supramolecular, concentric stacked and densely packed lamellar, nonliposomal structures. That the formation of such supramolecular assemblies supports the intermolecular interactions of ceramide is indicated by the SERS data. The unique spectral features that are assigned to the ceramide-containing lipid model systems here enable an identification of these molecules in biological systems and allow us to obtain information on their structure and interaction by SERS.}, language = {en} } @article{KnappAttingerHuth2022, author = {Knapp, Nikolai and Attinger, Sabine and Huth, Andreas}, title = {A question of scale: modeling biomass, gain and mortality distributions of a tropical forest}, series = {Biogeosciences}, volume = {19}, journal = {Biogeosciences}, number = {20}, publisher = {Copernicus}, address = {Katlenburg-Lindau [u.a.]}, issn = {1726-4170}, doi = {10.5194/bg-19-4929-2022}, pages = {4929 -- 4944}, year = {2022}, abstract = {Describing the heterogeneous structure of forests is often challenging. One possibility is to analyze forest biomass in different plots and to derive plot-based frequency distributions. However, these frequency distributions depend on the plot size and thus are scale dependent. This study provides insights about transferring them between scales. Understanding the effects of scale on distributions of biomass is particularly important for comparing information from different sources such as inventories, remote sensing and modeling, all of which can operate at different spatial resolutions. Reliable methods to compare results of vegetation models at a grid scale with field data collected at smaller scales are still missing. The scaling of biomass and variables, which determine the forest biomass, was investigated for a tropical forest in Panama. Based on field inventory data from Barro Colorado Island, spanning 50 ha over 30 years, the distributions of aboveground biomass, biomass gain and mortality were derived at different spatial resolutions, ranging from 10 to 100 m. Methods for fitting parametric distribution functions were compared. Further, it was tested under which assumptions about the distributions a simple stochastic simulation forest model could best reproduce observed biomass distributions at all scales. Also, an analytical forest model for calculating biomass distributions at equilibrium and assuming mortality as a white shot noise process was tested. Scaling exponents of about 0.47 were found for the standard deviations of the biomass and gain distributions, while mortality showed a different scaling relationship with an exponent of 0.3. Lognormal and gamma distribution functions fitted with the moment matching estimation method allowed for consistent parameter transfers between scales. Both forest models (stochastic simulation and analytical solution) were able to reproduce observed biomass distributions across scales, when combined with the derived scaling relationships. The study demonstrates a way of how to approach the scaling problem in model-data comparisons by providing a transfer relationship. Further research is needed for a better understanding of the mechanisms that shape the frequency distributions at the different scales.}, language = {en} } @article{PetersenNiemzCescaetal.2021, author = {Petersen, Gesa Maria and Niemz, Peter and Cesca, Simone and Mouslopoulou, Vasiliki and Bocchini, Gian Maria}, title = {Clusty, the waveform-based network similarity clustering toolbox}, series = {Geophysical journal international / the Royal Astronomical Society, the Deutsche Geophysikalische Gesellschaft and the European Geophysical Society}, volume = {224}, journal = {Geophysical journal international / the Royal Astronomical Society, the Deutsche Geophysikalische Gesellschaft and the European Geophysical Society}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggaa568}, pages = {2044 -- 2059}, year = {2021}, abstract = {Clusty is a new open source toolbox dedicated to earthquake clustering based on waveforms recorded across a network of seismic stations. Its main application is the study of active faults and the detection and characterization of faults and fault networks. By using a density-based clustering approach, earthquakes pertaining to a common fault can be recognized even over long fault segments, and the first-order geometry and extent of active faults can be inferred. Clusty implements multiple techniques to compute a waveform based network similarity from maximum cross-correlation coefficients at multiple stations. The clustering procedure is designed to be transparent and parameters can be easily tuned. It is supported by a number of analysis visualization tools which help to assess the homogeneity within each cluster and the differences among distinct clusters. The toolbox returns graphical representations of the results. A list of representative events and stacked waveforms facilitate further analyses like moment tensor inversion. Results obtained in various frequency bands can be combined to account for large magnitude ranges. Thanks to the simple configuration, the toolbox is easily adaptable to new data sets and to large magnitude ranges. To show the potential of our new toolbox, we apply Clusty to the aftershock sequence of the M-w 6.9 25 October 2018 Zakynthos (Greece) Earthquake. Thanks to the complex tectonic setting at the western termination of the Hellenic Subduction System where multiple faults and faulting styles operate simultaneously, the Zakynthos data set provides an ideal case-study for our clustering analysis toolbox. Our results support the activation of several faults and provide insight into the geometry of faults or fault segments. We identify two large thrust faulting clusters in the vicinity of the main shock and multiple strike-slip clusters to the east, west and south of these clusters. Despite its location within the largest thrust cluster, the main shock does not show a high waveform similarity to any of the clusters. This is consistent with the results of other studies suggesting a complex failure mechanism for the main shock. We propose the existence of conjugated strike-slip faults in the south of the study area. Our waveform similarity based clustering toolbox is able to reveal distinct event clusters which cannot be discriminated based on locations and/or timing only. Additionally, the clustering results allows distinction between fault and auxiliary planes of focal mechanisms and to associate them to known active faults.}, language = {en} } @article{SerranoMunozUlbrichtFritschetal.2021, author = {Serrano-Munoz, Itziar and Ulbricht, Alexander and Fritsch, Tobias and Mishurova, Tatiana and Kromm, Arne and Hofmann, Michael and Wimpory, Robert C. and Evans, Alexander and Bruno, Giovanni}, title = {Scanning manufacturing parameters determining the residual stress state in LPBF IN718 small parts}, series = {Advanced engineering materials}, volume = {23}, journal = {Advanced engineering materials}, number = {7}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1438-1656}, doi = {10.1002/adem.202100158}, pages = {13}, year = {2021}, abstract = {The influence of scan strategy on the residual stress (RS) state of an as-built IN718 alloy produced by means of laser powder bed fusion (LPBF) is investigated. Two scan vector rotations (90 degrees-alternation and 67 degrees-rotation), each produced following two different scan vector lengths (long and short), are used to manufacture four rectangular prisms. Neutron diffraction (ND) and laboratory X-ray diffraction (XRD) techniques are used to map the bulk and surface RS state, respectively. The distortion induced upon removal from the baseplate is measured via profilometry. XRD measurements show that the two long scan vector strategies lead to higher RS when compared with the equivalent short scan vector strategies. Also, the 67 degrees-rotation strategies generate lower RS than their 90 degrees-alternation counterparts. Due to the lack of reliable stress-free d0 references, the ND results are analyzed using von Mises stress. In general, ND results show significant RS spatial non-uniformity. A comparison between ND and distortion results indicates that the RS component parallel to the building direction (Z-axis) has a predominant role in the Z-displacement. The use of a stress balance scheme allows to discuss the d0 variability along the length of the specimens, as well as examine the absolute RS state.}, language = {en} } @article{DeyBookhagenThiedeetal.2022, author = {Dey, Saptarshi and Bookhagen, Bodo and Thiede, Rasmus C. and Wittmann, Hella and Chauhan, Naveen and Jain, Vikrant and Strecker, Manfred R.}, title = {Impact of Late Pleistocene climate variability on paleo-erosion rates in the western Himalaya}, series = {Earth and planetary science letters}, volume = {578}, journal = {Earth and planetary science letters}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, issn = {0012-821X}, doi = {10.1016/j.epsl.2021.117326}, pages = {12}, year = {2022}, abstract = {It has been proposed that at short timescales of 10(2)-10(5) yr, climatic variability can explain variations in sediment flux, but in orogens with pronounced climatic gradients rate changes caused by the oscillating efficiency in rainfall, runoff, and/or sediment transport and deposition are still not well-constrained. To explore landscape responses under variable climatic forcing, we evaluate time windows of prevailing sediment aggradation and related paleo-erosion rates from the southern flanks of the Dhauladhar Range in the western Himalaya. We compare past and present Be-10-derived erosion rates of well-dated Late Pleistocene fluvial landforms and modern river sediments and reconstruct the sediment aggradation and incision history based on new luminescence data. Our results document significant variations in erosion rates ranging from 0.1 to 3.4 mm/yr over the Late Pleistocene. We find that, during times of weak monsoon intensity, the moderately steep areas (hillslope angles of 27 +/- 13 degrees) erode at lower rates of 0.1-0.4 mm/yr compared to steeper (>40 degrees) crestal regions of the Dhauladhar Range that erode at 0.8-1.3 mm/yr. In contrast, during several millennia of stronger monsoon intensity, both the moderately steep and high slope areas record higher erosion rates (>1-3.4 mm/yr). Lithological clast-count analysis shows that this increase of erosion is focused in the moderately steep areas, where Lesser Himalayan rocks are exposed. Our data thus highlight the highly non-linear response of climatic forcing on landscape evolution and suggest complex depositional processes and sedimentary signals in downstream areas. (C) 2021 Elsevier B.V. All rights reserved.}, language = {en} }