@article{HackerSteinbergBannasch1998, author = {Hacker, Hans-J{\"o}rg and Steinberg, Pablo and Bannasch, Peter}, title = {Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine supplemented diet}, year = {1998}, language = {en} } @article{SteinbergKlingelhoefferSchaeferetal.1999, author = {Steinberg, Pablo and Klingelh{\"o}ffer, Alexandra and Sch{\"a}fer, Angelika and W{\"u}st, G{\"u}nter and Weiße, G{\"u}nter and Oesch, Franz and Eigenbrodt, Erich}, title = {Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats}, year = {1999}, language = {en} } @article{MazurekEigenbrodtFailingetal.1999, author = {Mazurek, Sybille and Eigenbrodt, Erich and Failing, Klaus and Steinberg, Pablo}, title = {Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells}, year = {1999}, language = {en} } @article{SteinbergFischerArandetal.1999, author = {Steinberg, Pablo and Fischer, Thomas M. and Arand, Michael and Park, Eunju and Elmadfa, Ibrahim and Rimkus, Gerhard and Brunn, Hubertus and Dienes, Hans-Peter}, title = {Acute hepatotoxicity of the polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline (AHTN)}, year = {1999}, language = {en} } @article{BluvshteinGlassVolohonskyetal.1999, author = {Bluvshtein, Evgenia and Glass, George and Volohonsky, Gloria and Yaakubowitz, Margalit and Harness, Ella and Smorodinsky, Nechama and Seidel, Albrecht and Frank, Heinz and Stark, Avishay Abraham and Steinberg, Pablo}, title = {Inhibition of the hydrolytic and transpeptidatic activities of rat kidney gamma-glutamyltranspeptidase by specific monoclonal antibodies}, year = {1999}, language = {en} } @article{SchlegerBeckerOeschetal.1999, author = {Schleger, C. and Becker, Rolf and Oesch, Franz and Steinberg, Pablo}, title = {The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells}, year = {1999}, language = {en} } @article{HengstlerVanDerBurgSteinbergetal.1999, author = {Hengstler, Jan Georg and VanDerBurg, Bart and Steinberg, Pablo and Oesch, Franz}, title = {Interspecies differences in cancer susceptibility and toxicity}, year = {1999}, language = {en} } @article{SteinbergFischerKiuliesetal.1999, author = {Steinberg, Pablo and Fischer, Thomas M. and Kiulies, Sandra and Biefang, Katja and Platt, Karl-Ludwig and Oesch, Franz and B{\"o}ttger, Thomas and Bulitta, Clemens and Kempf, Peter and Hengstler, Jan Georg}, title = {Drug metabolizing capacity of cryopreserved human, rat and mouse liver parenchymal cells in suspension}, year = {1999}, language = {en} } @article{HengstlerUteschSteinberg2000, author = {Hengstler, Jan Georg and Utesch, D. and Steinberg, Pablo}, title = {Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction}, year = {2000}, language = {en} } @article{SchlegerHeckSteinberg2000, author = {Schleger, C. and Heck, R. and Steinberg, Pablo}, title = {The role of wild-type and mutated N-ras in the malignant transformation of liver cells}, year = {2000}, language = {en} } @article{HengstlerRingelBiefangetal.2000, author = {Hengstler, Jan Georg and Ringel, M. and Biefang, Katja and Hammel, S. and Milbert, U. and Gerl, M. and Klebach, M. and Diener, B. and Platt, Karl-Ludwig and B{\"o}ttger, Thomas and Steinberg, Pablo and Oesch, Franz}, title = {Cultures with cryopreserved hepatocytes : applicability for studies of enzyme induction}, year = {2000}, language = {en} } @article{SteinbergZschalerThometal.2001, author = {Steinberg, Pablo and Zschaler, Ingrid and Thom, Elke and Kuna, Manuela and W{\"u}st, G{\"u}nter and Sch{\"a}fer-Schwebel, Angelika and M{\"u}ller, Rolf and Kramer, Peter-J{\"u}rgen and Weiße, G{\"u}nter}, title = {The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses}, issn = {0340-5761}, doi = {10.1007/s002040100274}, year = {2001}, language = {en} } @article{KomloshVolohonskyPoratetal.2001, author = {Komlosh, A. and Volohonsky, Gloria and Porat, Noga and Tuby, chen n. y. h. and Bluvshtein, Evgenia and Steinberg, Pablo and Oesch, Franz and Stark, Avishay Abraham}, title = {Gamma-glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines}, year = {2001}, language = {en} } @article{BarlowGreigBridgesetal.2002, author = {Barlow, S. M. and Greig, J. B. and Bridges, J. W. and Carere, A. and Carpy, A. J. and Galli, Corrado L. and Kleiner, J. and Knudsen, I. and Koeter, H. B. and Levy, L. S. and Madsen, C. and Mayer, S. and Narbonne, J. F. and Pfannkuch, F. and Prodanchuk, M. G. and Smith, Mason R. and Steinberg, Pablo}, title = {Hazard identification by methods of animal-based toxicology}, year = {2002}, language = {en} } @article{DybingDoeGrotenetal.2002, author = {Dybing, E. and Doe, J. and Groten, J. and Kleiner, J. and O'Brien, J. and Renwick, A. G. and Schlatter, J. and Steinberg, Pablo and Tritschler, A. and Walker, R. and Younes, M.}, title = {Hazard characterisation of chemicals in food and diet : dose response, mechanisms and extrapolation issues}, year = {2002}, language = {en} } @article{VolohonskyTubyPoratetal.2002, author = {Volohonsky, Gloria and Tuby, Chen N. Y. H. and Porat, Noga and Wellman-Rousseau, Maria and Visvikis, Athanase and Leroy, Pierre and Rashi, Sharon and Steinberg, Pablo and Stark, Avishay Abraham}, title = {A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells}, year = {2002}, language = {en} } @article{StarkPoratVolohonskyetal.2003, author = {Stark, Avishay abraham and Porat, Noga and Volohonsky, Gloria and Konlosh, A. and Bluvshtein, Evgenia and Tubi, C. and Steinberg, Pablo}, title = {The role of gamma-glutamyl transpeptidase in the biosynthesis of glutathione}, year = {2003}, language = {en} } @article{OkanoShiotaMatsumotoetal.2003, author = {Okano, J. and Shiota, G. and Matsumoto, K. and Yasui, S. and Kurimasa, A. and Hisatome, I. and Steinberg, Pablo and Murawaki, Y.}, title = {Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway}, year = {2003}, language = {en} } @article{BartschZschalerHaseloffetal.2003, author = {Bartsch, Ingrid and Zschaler, Ingrid and Haseloff, Monika and Steinberg, Pablo}, title = {Establishment of a long-term culture system for rat colon epithelial cells}, issn = {1071-2690}, doi = {10.1290/0404035.1}, year = {2003}, abstract = {The aim of this study was to establish a long-term culture. system for rat colon epithelia isolaled by incubating a 4-cm-long rat colon segment cut longitudinally with all ethylenediaminetetraacetic acid [disodium salt]- containing buffer, taken up in conditioned medium from the normal rat kidney fibroblast cell line NRK (i.e., the supernatant Of pure NRK cultures), directly plated on mitomycin C-treated NRK cells and subcultured with conditioned medium from NRK cells. Cells started to migrate out of the crypts shortly after plating them on NRK feeder layers. Some of the crypts fell apart during the isolation procedure. whereas the vast majority of them did it within I to 2 Ill after plating. The cells proliferated extremely slowly but continuously over a period of 4 mo and were epithelial because they expressed cytokeratin 19 and were stained by crystal violet at pH 2.8. In conclusion, the experimental system described ill this study allows to maintain rat colon epithelial cells for up to 4 mo in culture and can be used to Study the effects of a variety of tumor-modulating factors on growth and gene expression of normal colon epithelial cells in vitro}, language = {en} } @article{FuchsTeubnerSteinberg2004, author = {Fuchs, J. and Teubner, Wera and Steinberg, Pablo}, title = {The resistance of intestinal epithelial cells towards the transforming activity of 2-hydroxyamino-1-methyl-6- phenylimidazo[4,5-B]pyridine is accompanied by glutathione S-transferase induction}, issn = {0028-1298}, year = {2004}, language = {en} }