@article{XuNieWangetal.2021,
  author    = {Xu, Xun and Nie, Yan and Wang, Weiwei and Ma, Nan and Lendlein, Andreas},
  title     = {Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells},
  series = {MRS communications / a publication of the Materials Research Society},
  volume    = {11},
  journal   = {MRS communications / a publication of the Materials Research Society},
  number    = {4},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2159-6859},
  doi       = {10.1557/s43579-021-00049-5},
  pages     = {425 -- 431},
  year      = {2021},
  abstract  = {Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.},
  language  = {en}
}