@phdthesis{Harbart2024, author = {Harbart, Vanessa}, title = {The effect of protected cultivation on the nutritional quality of lettuce (Lactuca sativa var capitata L.) with a focus on antifogging additives in polyolefin covers}, doi = {10.25932/publishup-62937}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-629375}, school = {Universit{\"a}t Potsdam}, pages = {IV, 115}, year = {2024}, abstract = {Protected cultivation in greenhouses or polytunnels offers the potential for sustainable production of high-yield, high-quality vegetables. This is related to the ability to produce more on less land and to use resources responsibly and efficiently. Crop yield has long been considered the most important factor. However, as plant-based diets have been proposed for a sustainable food system, the targeted enrichment of health-promoting plant secondary metabolites should be addressed. These metabolites include carotenoids and flavonoids, which are associated with several health benefits, such as cardiovascular health and cancer protection. Cover materials generally have an influence on the climatic conditions, which in turn can affect the levels of secondary metabolites in vegetables grown underneath. Plastic materials are cost-effective and their properties can be modified by incorporating additives, making them the first choice. However, these additives can migrate and leach from the material, resulting in reduced service life, increased waste and possible environmental release. Antifogging additives are used in agricultural films to prevent the formation of droplets on the film surface, thereby increasing light transmission and preventing microbiological contamination. This thesis focuses on LDPE/EVA covers and incorporated antifogging additives for sustainable protected cultivation, following two different approaches. The first addressed the direct effects of leached antifogging additives using simulation studies on lettuce leaves (Lactuca sativa var capitata L). The second determined the effect of antifog polytunnel covers on lettuce quality. Lettuce is usually grown under protective cover and can provide high nutritional value due to its carotenoid and flavonoid content, depending on the cultivar. To study the influence of simulated leached antifogging additives on lettuce leaves, a GC-MS method was first developed to analyze these additives based on their fatty acid moieties. Three structurally different antifogging additives (reference material) were characterized outside of a polymer matrix for the first time. All of them contained more than the main fatty acid specified by the manufacturer. Furthermore, they were found to adhere to the leaf surface and could not be removed by water or partially by hexane. The incorporation of these additives into polytunnel covers affects carotenoid levels in lettuce, but not flavonoids, caffeic acid derivatives and chlorophylls. Specifically, carotenoids were higher in lettuce grown under polytunnels without antifog than with antifog. This has been linked to their effect on the light regime and was suggested to be related to carotenoid function in photosynthesis. In terms of protected cultivation, the use of LDPE/EVA polytunnels affected light and temperature, and both are closely related. The carotenoid and flavonoid contents of lettuce grown under polytunnels was reversed, with higher carotenoid and lower flavonoid levels. At the individual level, the flavonoids detected in lettuce did not differ however, lettuce carotenoids adapted specifically depending on the time of cultivation. Flavonoid reduction was shown to be transcriptionally regulated (CHS) in response to UV light (UVR8). In contrast, carotenoids are thought to be regulated post-transcriptionally, as indicated by the lack of correlation between carotenoid levels and transcripts of the first enzyme in carotenoid biosynthesis (PSY) and a carotenoid degrading enzyme (CCD4), as well as the increased carotenoid metabolic flux. Understanding the regulatory mechanisms and metabolite adaptation strategies could further advance the strategic development and selection of cover materials.}, language = {en} } @phdthesis{Cheng2024, author = {Cheng, Feng}, title = {Evolution and ontogeny of electric organ discharge in African weakly electric fish genus Campylomormyrus: a genomic and transcriptomic perspective}, doi = {10.25932/publishup-63017}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630172}, school = {Universit{\"a}t Potsdam}, pages = {176}, year = {2024}, abstract = {The African weakly electric fishes (Mormyridae) exhibit a remarkable adaptive radiation possibly due to their species-specific electric organ discharges (EODs). It is produced by a muscle-derived electric organ that is located in the caudal peduncle. Divergence in EODs acts as a pre-zygotic isolation mechanism to drive species radiations. However, the mechanism behind the EOD diversification are only partially understood. The aim of this study is to explore the genetic basis of EOD diversification from the gene expression level across Campylomormyrus species/hybrids and ontogeny. I firstly produced a high quality genome of the species C. compressirostris as a valuable resource to understand the electric fish evolution. The next study compared the gene expression pattern between electric organs and skeletal muscles in Campylomormyrus species/hybrids with different types of EOD duration. I identified several candidate genes with an electric organ-specific expression, e.g. KCNA7a, KLF5, KCNJ2, SCN4aa, NDRG3, MEF2. The overall genes expression pattern exhibited a significant association with EOD duration in all analyzed species/hybrids. The expression of several candidate genes, e.g. KCNJ2, KLF5, KCNK6 and KCNQ5, possibly contribute to the regulation of EOD duration in Campylomormyrus due to their increasing or decreasing expression. Several potassium channel genes showed differential expression during ontogeny in species and hybrid with EOD alteration, e.g. KCNJ2. I next explored allele specific expression of intragenus hybrids by crossing the duration EOD species C. compressirostris with the medium duration EOD species C. tshokwe and the elongated duration EOD species C. rhynchophorus. The hybrids exhibited global expression dominance of the C. compressirostris allele in the adult skeletal muscle and electric organ, as well as in the juvenile electric organ. Only the gene KCNJ2 showed dominant expression of the allele from C. rhynchophorus, and this was increasingly dominant during ontogeny. It hence supported our hypothesis that KCNJ2 is a key gene of regulating EOD duration. Our results help us to understand, from a genetic perspective, how gene expression effect the EOD diversification in the African weakly electric fish.}, language = {en} } @phdthesis{Stallasch2024, author = {Stallasch, Sophie E.}, title = {Optimizing power analysis for randomized experiments: Design parameters for student achievement}, doi = {10.25932/publishup-62939}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-629396}, school = {Universit{\"a}t Potsdam}, pages = {ix, 224}, year = {2024}, abstract = {Randomized trials (RTs) are promising methodological tools to inform evidence-based reform to enhance schooling. Establishing a robust knowledge base on how to promote student achievement requires sensitive RT designs demonstrating sufficient statistical power and precision to draw conclusive and correct inferences on the effectiveness of educational programs and innovations. Proper power analysis is therefore an integral component of any informative RT on student achievement. This venture critically hinges on the availability of reasonable input variance design parameters (and their inherent uncertainties) that optimally reflect the realities around the prospective RT—precisely, its target population and outcome, possibly applied covariates, the concrete design as well as the planned analysis. However, existing compilations in this vein show far-reaching shortcomings. The overarching endeavor of the present doctoral thesis was to substantively expand available resources devoted to tweak the planning of RTs evaluating educational interventions. At the core of this thesis is a systematic analysis of design parameters for student achievement, generating reliable and versatile compendia and developing thorough guidance to support apt power analysis to design strong RTs. To this end, the thesis at hand bundles two complementary studies which capitalize on rich data of several national probability samples from major German longitudinal large-scale assessments. Study I applied two- and three-level latent (covariate) modeling to analyze design parameters for a wide spectrum of mathematical-scientific, verbal, and domain-general achievement outcomes. Three vital covariate sets were covered comprising (a) pretests, (b) sociodemographic characteristics, and (c) their combination. The accumulated estimates were additionally summarized in terms of normative distributions. Study II specified (manifest) single-, two-, and three-level models and referred to influential psychometric heuristics to analyze design parameters and develop concise selection guidelines for covariate (a) types of varying bandwidth-fidelity (domain-identical, cross-domain, fluid intelligence pretests; sociodemographic characteristics), (b) combinations quantifying incremental validities, and (c) time lags of 1- to 7-year-lagged pretests scrutinizing validity degradation. The estimates for various mathematical-scientific and verbal achievement outcomes were meta-analytically integrated and employed in precision simulations. In doing so, Studies I and II addressed essential gaps identified in previous repertoires in six major dimensions: Taken together, this thesis accumulated novel design parameters and deliberate guidance for RT power analysis (1) tailored to four German student (sub)populations across the entire school career from Grade 1 to 12, (2) matched to 21 achievement (sub)domains, (3) adjusted for 11 covariate sets enriched by empirically supported guidelines, (4) adapted to six RT designs, (5) suitable for latent and manifest analysis models, (6) which were cataloged along with quantifications of their associated uncertainties. These resources are complemented by a plethora of illustrative application examples to gently direct psychological and educational researchers through pivotal steps in the process of RT design. The striking heterogeneity of the design parameter estimates across all these dimensions constitutes the overall, joint key result of Studies I and II. Hence, this work convincingly reinforces calls for a close match between design parameters and the specific peculiarities of the target RT's research context. All in all, the present doctoral thesis offers a—so far unique—nuanced and extensive toolkit to optimize power analysis for sound RTs on student achievement in the German (and similar) school context. It is of utmost importance that research does not tire to spawn robust evidence on what actually works to improve schooling. With this in mind, I hope that the emerging compendia and guidance contribute to the quality and rigor of our randomized experiments in psychology and education.}, language = {en} } @phdthesis{Kersting2024, author = {Kersting, Katerina}, title = {Development of a CRISPR/Cas gene editing technique for the coccolithophore Chrysotila carterae}, school = {Universit{\"a}t Potsdam}, pages = {137}, year = {2024}, language = {en} } @phdthesis{Schallau2024, author = {Schallau, Juliane}, title = {"Maybe Happen Is Never Once" - temporalities of guilt in William Faulkner}, doi = {10.25932/publishup-62885}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-628858}, school = {Universit{\"a}t Potsdam}, pages = {iv, 171}, year = {2024}, abstract = {This study focuses on William Faulkner, whose works explore the demise of the slavery-based Old South during the Civil War in a highly experimental narrative style. Central to this investigation is the analysis of the temporal dimensions of both individual and collective guilt, thus offering a new approach to the often-discussed problem of Faulkner's portrayal of social decay. The thesis examines how Faulkner re-narrates the legacy of the Old South as a guilt narrative and argues that Faulkner uses guilt in order to corroborate his concept of time and the idea of the continuity of the past. The focus of the analysis is on three of Faulkner's arguably most important novels: The Sound and the Fury, Absalom, Absalom!, and Go Down, Moses. Each of these novels features a main character deeply overwhelmed by the crimes of the past, whether private, familial, or societal. As a result, guilt is explored both from a domestic as well as a social perspective. In order to show how Faulkner blends past and present by means of guilt, this work examines several methods and motifs borrowed from different fields and genres with which Faulkner narratively negotiates guilt. These include religious notions of original sin, the motif of the ancestral curse prevalent in the Southern Gothic genre, and the psychological concept of trauma. Each of these motifs emphasizes the temporal dimensions of guilt, which are the core of this study, and makes clear that guilt in Faulkner's work is primarily to be understood as a temporal rather than a moral problem.}, language = {en} } @phdthesis{Tomović2024, author = {Tomović, Jelena}, title = {Sexualit{\"a}t in der Geschichte}, series = {Schriften des Fr{\"u}hneuzeitzentrums Potsdam}, volume = {12}, journal = {Schriften des Fr{\"u}hneuzeitzentrums Potsdam}, publisher = {V\&R unipress - Brill Deutschland GmbH}, address = {G{\"o}ttingen}, isbn = {978-3-8471-1686-8}, issn = {2198-5251}, doi = {10.14220/9783737016865}, school = {Universit{\"a}t Potsdam}, pages = {336}, year = {2024}, abstract = {Jelena Tomović f{\"u}hrt in diesem Band durch die Entwicklungen unserer sexuellen Sprache und Praktiken. Sie zeigt, dass die Art und Weise, wie {\"u}ber Sexualit{\"a}t gesprochen wird, nicht nur ein Spiegelbild, sondern auch ein treibender Faktor f{\"u}r soziale Ver{\"a}nderungen ist. Die Studie stellt die konventionelle Vorstellung von Sexualit{\"a}t in Frage und f{\"u}hrt die Lesenden in eine Welt der subtilen Nuancen und kulturellen Ver{\"a}nderungen. Mit kommunikationstheoretischen Ans{\"a}tzen, dem praxeologischen Ansatz, ihrer sozialkonstruktivistischen Grundannahme und einem klaren Fokus auf Akteur*innen bietet die Autorin eine frische Perspektive auf die Geschichte der Sexualit{\"a}t. Das Buch er{\"o}ffnet neue Wege f{\"u}r die Erforschung und das Verst{\"a}ndnis von Intimit{\"a}t und sozialer Kommunikation.}, language = {de} } @phdthesis{Drescher2024, author = {Drescher, Cedric}, title = {Die Bek{\"a}mpfung transnationaler Kriminalit{\"a}t im Kontext fragiler Staatlichkeit}, doi = {10.25932/publishup-62854}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-628542}, school = {Universit{\"a}t Potsdam}, pages = {XIII, 541, LVIII}, year = {2024}, abstract = {Die Arbeit „Die Bek{\"a}mpfung transnationaler Kriminalit{\"a}t im Kontext fragiler Staatlichkeit" widmet sich dem Ph{\"a}nomen grenz{\"u}berschreitend t{\"a}tiger Akteure der organisierten Kriminalit{\"a}t die den Umstand ausnutzen, dass einige international anerkannte Regierungen nur eine unzureichende Kontrolle {\"u}ber Teile ihres Staatsgebietes aus{\"u}ben. Es wird untersucht, weshalb der durch die internationale Staatengemeinschaft geschaffene Rechtsrahmen, zur Bek{\"a}mpfung transnationaler Kriminalit{\"a}tsph{\"a}nomene im Kontext dieser fragilen Staaten, nicht oder nur defizit{\"a}r dazu beitr{\"a}gt die Kriminalit{\"a}tsph{\"a}nomene zu bek{\"a}mpfen. Nachdem zun{\"a}chst er{\"o}rtert wird, was im Rahmen der Untersuchung unter dem Begriff der transnationalen Kriminalit{\"a}t verstanden wird, wird der internationale Rechtsrahmen zur Bek{\"a}mpfung anhand von f{\"u}nf beispielhaft ausgew{\"a}hlten transnationalen Kriminalit{\"a}tsph{\"a}nomenen beschrieben. Im darauffolgenden Hauptteil der Untersuchung wird der Frage nachgegangen, weshalb dieser durch die internationale Staatengemeinschaft geschaffene Rechtsrahmen, gerade in fragilen Staaten, kaum einen Beitrag dazu leistet solchen Kriminalit{\"a}tsph{\"a}nomenen effektiv zu begegnen. Dabei wird festgestellt, dass die Genese des internationalen Rechtsrahmens zu einem Legitimit{\"a}tsdefizit desselbigen f{\"u}hrt. Auch die mangelhafte Ber{\"u}cksichtigung der speziellen Lebensrealit{\"a}ten, die in vielen fragilen Staaten vorzufinden sind, wirkt sich negativ auf die Durchsetzbarkeit des internationalen Rechtsrahmens aus. Es wird dargelegt, dass unterschiedlich hohe menschenrechtliche Schutzstandards zu Normenkollisionen bei der internationalen Zusammenarbeit der Staaten f{\"u}hren, insbesondere im Rahmen der internationalen Rechtshilfe. Da gerade fragile Staaten h{\"a}ufig durch eine defizit{\"a}re menschenrechtliche Situation gekennzeichnet sind, stellt dies konsolidierte Staaten im Rahmen der Zusammenarbeit mit fragilen Staaten {\"o}fters vor Herausforderungen. Schließlich wird aufgezeigt, dass auch die extraterritoriale Jurisdiktion und somit die strafrechtliche Verfolgung transnationaler Straftaten durch Drittstaaten mit rechtlichen und praktischen Problemen einhergeht. In einem letzten Kapitel der Arbeit wird der Frage nachgegangen, ob nicht ein alternativer Strafverfolgungsmechanismus geschaffen werden sollte, um transnationale Kriminalit{\"a}tsph{\"a}nomene zu verfolgen, die aus fragilen Staaten heraus begangen werden und wie ein solch alternativer Strafverfolgungsmechanismus konkret ausgestaltet sein sollte.}, language = {de} } @phdthesis{Behrmann2024, author = {Behrmann, Helga}, title = {Digital Fashion}, doi = {10.25932/publishup-62026}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-620269}, school = {Universit{\"a}t Potsdam}, pages = {309}, year = {2024}, abstract = {Das virtuelle Kleid als mediale und soziokulturelle Alltagserscheinung der Gegenwart bildet den Gegenstand der vorliegenden interdisziplin{\"a}ren Unter-suchung. An der Schnittstelle zwischen Menschen, Medien und Mode ist das virtuelle Kleid an unrealen Orten und in synthetischen Situationen ausschließlich auf einem Screen erfahrbar. In diesem Dispositiv lassen sich K{\"o}rperkonzepte, Darstellungskonventionen, soziale Handlungsmuster und Kommunikations-strategien ausmachen, die zwar auf einer radikalen Abl{\"o}sung vom textilen Material beruhen, aber dennoch nicht ohne sehr konkrete Verweise auf das textile Material auskommen. Dies f{\"u}hrt zu neuen Ans{\"a}tzen der Auseinandersetzung mit Kleidern, die nun als Visualisierung geb{\"u}ndelter Datenpakete zu betrachten sind. Die dynamische Entwicklung neuer Erscheinungsformen und deren nahtlose Einbindung in traditionelle Gesch{\"a}ftsmodelle und bestehende Modekonzepte macht eine Positionsbestimmung notwendig, insbesondere im Hinblick auf gegenw{\"a}rtige Nachhaltigkeitsdiskurse um immaterielle Produkte. F{\"u}r diese Studie liefern die hinter den Bildern liegenden Prozesse der {\"o}konomischen Ausrichtung, der Herstellung, der Verwendung und der Rezeption den methodologischen Zugang f{\"u}r die Analyse. Mithilfe eines typologisierenden Instrumentariums wird aus der Vielzahl und Vielfalt der Darstellungen ein Set an forschungsleitenden Beispielen zusammengestellt, welche dann in einer mehrstufigen Kontextanalyse zu einer begrifflichen Fassung des virtuellen Kleides sowie zu f{\"u}nf Kontexteinheiten f{\"u}hren. Am Beispiel des virtuellen Kleides zeichnet diese Untersuchung den technischen, gesellschaftlichen und sozialen Wandel nach und arbeitet seine Bedeutung f{\"u}r zuk{\"u}nftige Modeentwicklungen heraus. Damit leistet die Untersuchung einen Beitrag zur medien- und sozialwissenschaftlichen Modeforschung der Gegenwart.}, language = {de} } @phdthesis{Koehler2024, author = {K{\"o}hler, Wolfgang}, title = {Challenges of efficient and compliant data processing}, doi = {10.25932/publishup-62784}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-627843}, school = {Universit{\"a}t Potsdam}, pages = {195}, year = {2024}, abstract = {Die fortschreitende Digitalisierung ver{\"a}ndert die Gesellschaft und hat weitreichende Auswirkungen auf Menschen und Unternehmen. Grundlegend f{\"u}r diese Ver{\"a}nderungen sind die neuen technologischen M{\"o}glichkeiten, Daten in immer gr{\"o}ßerem Umfang und f{\"u}r vielf{\"a}ltige neue Zwecke zu verarbeiten. Von besonderer Bedeutung ist dabei die Verf{\"u}gbarkeit großer und qualitativ hochwertiger Datens{\"a}tze, insbesondere auf Basis personenbezogener Daten. Sie werden entweder zur Verbesserung der Produktivit{\"a}t, Qualit{\"a}t und Individualit{\"a}t von Produkten und Dienstleistungen oder gar zur Entwicklung neuartiger Dienstleistungen verwendet. Heute wird das Nutzerverhalten, trotz weltweit steigender gesetzlicher Anforderungen an den Schutz personenbezogener Daten, aktiver und umfassender verfolgt als je zuvor. Dies wirft vermehrt ethische, moralische und gesellschaftliche Fragen auf, die nicht zuletzt durch popul{\"a}re F{\"a}lle des Datenmissbrauchs in den Vordergrund der politischen Debatte ger{\"u}ckt sind. Angesichts dieses Diskurses und der gesetzlichen Anforderungen muss heutiges Datenmanagement drei Bedingungen erf{\"u}llen: Erstens die Legalit{\"a}t bzw. Gesetzeskonformit{\"a}t der Nutzung, zweitens die ethische Legitimit{\"a}t. Drittens sollte die Datennutzung aus betriebswirtschaftlicher Sicht wertsch{\"o}pfend sein. Im Rahmen dieser Bedingungen verfolgt die vorliegende kumulative Dissertation vier Forschungsziele mit dem Fokus, ein besseres Verst{\"a}ndnis (1) der Herausforderungen bei der Umsetzung von Gesetzen zum Schutz von Privatsph{\"a}re, (2) der Faktoren, die die Bereitschaft der Kunden zur Weitergabe pers{\"o}nlicher Daten beeinflussen, (3) der Rolle des Datenschutzes f{\"u}r das digitale Unternehmertum und (4) der interdisziplin{\"a}ren wissenschaftlichen Bedeutung, deren Entwicklung und Zusammenh{\"a}nge zu erlangen.}, language = {en} } @phdthesis{Shipova2024, author = {Shipova, Evgeniya}, title = {Formal analysis of {\`e}to-clefts in Russian: syntax and semantics}, doi = {10.25932/publishup-63014}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630149}, school = {Universit{\"a}t Potsdam}, pages = {219}, year = {2024}, abstract = {{\`E}to-clefts are Russian focus constructions with the demonstrative pronoun {\`e}to 'this' at the beginning: "{\`E}to Mark vyigral gonku" ("It was Mark who won the race"). They are often being compared with English it-clefts, German es-clefts, as well as the corresponding focus-background structures in other languages. In terms of semantics, {\`e}to-clefts have two important properties which are cross-linguistically typical for clefts: existence presupposition ("Someone won the race") and exhaustivity ("Nobody except Mark won the race"). However, the exhaustivity effects are not as strong as exhaustivity effects in structures with the exclusive only and require more research. At the same time, the question if the syntactic structure of {\`e}to-clefts matches the biclausal structure of English and German clefts, remains open. There are arguments in favor of biclausality, as well as monoclausality. Besides, there is no consistency regarding the status of {\`e}to itself. Finally, the information structure of {\`e}to-clefts has remained underexplored in the existing literature. This research investigates the information-structural, syntactic, and semantic properties of Russian clefts, both theoretically (supported by examples from Russian text corpora and judgments from native speakers) and experimentally. It is determined which desired changes in the information structure motivate native speakers to choose an {\`e}to-cleft and not the canonical structure or other focus realization tools. Novel syntactic tests are conducted to find evidence for bi-/monoclausality of {\`e}to-clefts, as well as for base-generation or movement of the cleft pivot. It is hypothesized that {\`e}to has a certain important function in clefts, and its status is investigated. Finally, new experiments on the nature of exhaustivity in {\`e}to-clefts are conducted. They allow for direct cross-linguistic comparison, using an incremental-information paradigm with truth-value judgments. In terms of information structure, this research makes a new proposal that presents {\`e}to-clefts as structures with an inherent focus-background bipartitioning. Even though {\`e}to-clefts are used in typical focus contexts, evidence was found that {\`e}to-clefts (as well as Russian thetic clefts) allow for both new information focus and contrastive focus. {\`E}to-clefts are pragmatically acceptable when a singleton answer to the implied question is expected (e.g. "It was Mark who won the race" but not "It was Mark who came to the party"). Importantly, {\`e}to in Russian clefts is neither dummy, nor redundant, but is a topic expression; conveys familiarity which triggers existence presupposition; refers to an instantiated event, or a known/perceivable situation; finally, {\`e}to plays an important role in the spoken language as a tool for speech coherency and a focus marker. In terms of syntax, this research makes a new monoclausal proposal and shows evidence that the cleft pivot undergoes movement to the left peripheral position. {\`E}to is proposed to be TopP. Finally, in terms of semantics, a novel cross-linguistic evaluation of Russian clefts is made. Experiments show that the exhaustivity inference in {\`e}to-clefts is not robust. Participants used different strategies in resolving exhaustivity, falling into 2 groups: one group considered {\`e}to-clefts exhaustive, while another group considered them non-exhaustive. Hence, there is evidence for the pragmatic nature of exhaustivity in {\`e}to-clefts. The experimental results for {\`e}to-clefts are similar to the experimental results for clefts in German, French and Akan. It is concluded that speakers use different tools available in their languages to produce structures with similar interpretive properties.}, language = {en} } @phdthesis{Rubertus2024, author = {Rubertus, Elina}, title = {Coarticulatory changes across childhood}, doi = {10.25932/publishup-63012}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630123}, school = {Universit{\"a}t Potsdam}, pages = {X, 131}, year = {2024}, abstract = {The present dissertation investigates changes in lingual coarticulation across childhood in German-speaking children from three to nine years of age and adults. Coarticulation refers to the mismatch between the abstract phonological units and their seemingly commingled realization in continuous speech. Being a process at the intersection of phonology and phonetics, addressing its changes across childhood allows for insights in speech motor as well as phonological developments. Because specific predictions for changes in coarticulation across childhood can be derived from existing speech production models, investigating children's coarticulatory patterns can help us model human speech production. While coarticulatory changes may shed light on some of the central questions of speech production development, previous studies on the topic were sparse and presented a puzzling picture of conflicting findings. One of the reasons for this lack is the difficulty in articulatory data acquisition in a young population. Within the research program this dissertation is embedded in, we accepted this challenge and successfully set up the hitherto largest corpus of articulatory data from children using ultrasound tongue imaging. In contrast to earlier studies, a high number of participants in tight age cohorts across a wide age range and a thoroughly controlled set of pseudowords allowed for statistically powerful investigations of a process known as variable and complicated to track. The specific focus of my studies is on lingual vocalic coarticulation as measured in the horizontal position of the highest point of the tongue dorsum. Based on three studies on a) anticipatory coarticulation towards the left, b) carryover coarticulation towards the right side of the utterance, and c) anticipatory coarticulatory extent in repeated versus read aloud speech, I deduct the following main theses: 1. Maturing speech motor control is responsible for some developmental changes in coarticulation. 2. Coarticulation can be modeled as the coproduction of articulatory gestures. 3. The developmental change in coarticulation results from a decrease of vocalic activation width.}, language = {en} } @phdthesis{Martin2024, author = {Martin, Katja}, title = {Beerdigen oder verbrennen?}, publisher = {arijeh-verlag}, address = {Potsdam}, isbn = {978-3-944693-04-0}, school = {Universit{\"a}t Potsdam}, pages = {398}, year = {2024}, language = {de} } @phdthesis{Fitzner2024, author = {Fitzner, Maria}, title = {Cultivation of selected halophytes in saline indoor farming and modulation of cultivation conditions to optimize metabolite profiles for human nutrition}, doi = {10.25932/publishup-62697}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626974}, school = {Universit{\"a}t Potsdam}, pages = {178}, year = {2024}, abstract = {With the many challenges facing the agricultural system, such as water scarcity, loss of arable land due to climate change, population growth, urbanization or trade disruptions, new agri-food systems are needed to ensure food security in the future. In addition, healthy diets are needed to combat non-communicable diseases. Therefore, plant-based diets rich in health-promoting plant secondary metabolites are desirable. A saline indoor farming system is representing a sustainable and resilient new agrifood system and can preserve valuable fresh water. Since indoor farming relies on artificial lighting, assessment of lighting conditions is essential. In this thesis, the cultivation of halophytes in a saline indoor farming system was evaluated and the influence of cultivation conditions were assessed in favor of improving the nutritional quality of halophytes for human consumption. Therefore, five selected edible halophyte species (Brassica oleracea var. palmifolia, Cochlearia officinalis, Atriplex hortensis, Chenopodium quinoa, and Salicornia europaea) were cultivated in saline indoor farming. The halophyte species were selected for to their salt tolerance levels and mechanisms. First, the suitability of halophytes for saline indoor farming and the influence of salinity on their nutritional properties, e.g. plant secondary metabolites and minerals, were investigated. Changes in plant performance and nutritional properties were observed as a function of salinity. The response to salinity was found to be species-specific and related to the salt tolerance mechanism of the halophytes. At their optimal salinity levels, the halophytes showed improved carotenoid content. In addition, a negative correlation was found between the nitrate and chloride content of halophytes as a function of salinity. Since chloride and nitrate can be antinutrient compounds, depending on their content, monitoring is essential, especially in halophytes. Second, regional brine water was introduced as an alternative saline water resource in the saline indoor farming system. Brine water was shown to be feasible for saline indoor farming of halophytes, as there was no adverse effect on growth or nutritional properties, e.g. carotenoids. Carotenoids were shown to be less affected by salt composition than by salt concentration. In addition, the interaction between the salinity and the light regime in indoor farming and greenhouse cultivation has been studied. There it was shown that interacting light regime and salinity alters the content of carotenoids and chlorophylls. Further, glucosinolate and nitrate content were also shown to be influenced by light regime. Finally, the influence of UVB light on halophytes was investigated using supplemental narrow-band UVB LEDs. It was shown that UVB light affects the growth, phenotype and metabolite profile of halophytes and that the UVB response is species specific. Furthermore, a modulation of carotenoid content in S. europaea could be achieved to enhance health-promoting properties and thus improve nutritional quality. This was shown to be dose-dependent and the underlying mechanisms of carotenoid accumulation were also investigated. Here it was revealed that carotenoid accumulation is related to oxidative stress. In conclusion, this work demonstrated the potential of halophytes as alternative vegetables produced in a saline indoor farming system for future diets that could contribute to ensuring food security in the future. To improve the sustainability of the saline indoor farming system, LED lamps and regional brine water could be integrated into the system. Since the nutritional properties have been shown to be influenced by salt, light regime and UVB light, these abiotic stressors must be taken into account when considering halophytes as alternative vegetables for human nutrition.}, language = {en} } @phdthesis{Li2024, author = {Li, Yunfei}, title = {On the influence of density and morphology on the Urban Heat Island intensity}, doi = {10.25932/publishup-62150}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-621504}, school = {Universit{\"a}t Potsdam}, pages = {xviii, 119}, year = {2024}, abstract = {The urban heat island (UHI) effect, describing an elevated temperature of urban areas compared with their natural surroundings, can expose urban dwellers to additional heat stress, especially during hot summer days. A comprehensive understanding of the UHI dynamics along with urbanization is of great importance to efficient heat stress mitigation strategies towards sustainable urban development. This is, however, still challenging due to the difficulties of isolating the influences of various contributing factors that interact with each other. In this work, I present a systematical and quantitative analysis of how urban intrinsic properties (e.g., urban size, density, and morphology) influence UHI intensity. To this end, we innovatively combine urban growth modelling and urban climate simulation to separate the influence of urban intrinsic factors from that of background climate, so as to focus on the impact of urbanization on the UHI effect. The urban climate model can create a laboratory environment which makes it possible to conduct controlled experiments to separate the influences from different driving factors, while the urban growth model provides detailed 3D structures that can be then parameterized into different urban development scenarios tailored for these experiments. The novelty in the methodology and experiment design leads to the following achievements of our work. First, we develop a stochastic gravitational urban growth model that can generate 3D structures varying in size, morphology, compactness, and density gradient. We compare various characteristics, like fractal dimensions (box-counting, area-perimeter scaling, area-population scaling, etc.), and radial gradient profiles of land use share and population density, against those of real-world cities from empirical studies. The model shows the capability of creating 3D structures resembling real-world cities. This model can generate 3D structure samples for controlled experiments to assess the influence of some urban intrinsic properties in question. [Chapter 2] With the generated 3D structures, we run several series of simulations with urban structures varying in properties like size, density and morphology, under the same weather conditions. Analyzing how the 2m air temperature based canopy layer urban heat island (CUHI) intensity varies in response to the changes of the considered urban factors, we find the CUHI intensity of a city is directly related to the built-up density and an amplifying effect that urban sites have on each other. We propose a Gravitational Urban Morphology (GUM) indicator to capture the neighbourhood warming effect. We build a regression model to estimate the CUHI intensity based on urban size, urban gross building volume, and the GUM indicator. Taking the Berlin area as an example, we show the regression model capable of predicting the CUHI intensity under various urban development scenarios. [Chapter 3] Based on the multi-annual average summer surface urban heat island (SUHI) intensity derived from Land surface temperature, we further study how urban intrinsic factors influence the SUHI effect of the 5,000 largest urban clusters in Europe. We find a similar 3D GUM indicator to be an effective predictor of the SUHI intensity of these European cities. Together with other urban factors (vegetation condition, elevation, water coverage), we build different multivariate linear regression models and a climate space based Geographically Weighted Regression (GWR) model that can better predict SUHI intensity. By investigating the roles background climate factors play in modulating the coefficients of the GWR model, we extend the multivariate linear model to a nonlinear one by integrating some climate parameters, such as the average of daily maximal temperature and latitude. This makes it applicable across a range of background climates. The nonlinear model outperforms linear models in SUHI assessment as it captures the interaction of urban factors and the background climate. [Chapter 4] Our work reiterates the essential roles of urban density and morphology in shaping the urban thermal environment. In contrast to many previous studies that link bigger cities with higher UHI intensity, we show that cities larger in the area do not necessarily experience a stronger UHI effect. In addition, the results extend our knowledge by demonstrating the influence of urban 3D morphology on the UHI effect. This underlines the importance of inspecting cities as a whole from the 3D perspective. While urban 3D morphology is an aggregated feature of small-scale urban elements, the influence it has on the city-scale UHI intensity cannot simply be scaled up from that of its neighbourhood-scale components. The spatial composition and configuration of urban elements both need to be captured when quantifying urban 3D morphology as nearby neighbourhoods also cast influences on each other. Our model serves as a useful UHI assessment tool for the quantitative comparison of urban intervention/development scenarios. It can support harnessing the capacity of UHI mitigation through optimizing urban morphology, with the potential of integrating climate change into heat mitigation strategies.}, language = {en} } @phdthesis{Baumgart2024, author = {Baumgart, Lene}, title = {Die Ambivalenz der Digitalisierung}, doi = {10.25932/publishup-63040}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630401}, school = {Universit{\"a}t Potsdam}, pages = {137}, year = {2024}, abstract = {Ausgehend von der Beobachtung, dass die aktuelle Digitalisierungsforschung die Ambivalenz der Digitalisierung zwar erkennt, aber nicht zum Gegenstand ihrer Analysen macht, fokussiert die vorliegende kumulative Dissertation auf die ambivalente Dichotomie aus Potenzialen und Problemen, die mit digitalen Transformationen von Organisationen einhergeht. Entlang von sechs Publikationen wird mit einem systemtheoretischen Blick auf Organisationen die spannungsvolle Dichotomie hinsichtlich dreier ambivalenter Verh{\"a}ltnisse aufgezeigt: Erstens wird in Bezug auf das Verh{\"a}ltnis von Digitalisierung und Postb{\"u}rokratie deutlich, dass digitale Transformationen das Potenzial aufweisen, postb{\"u}rokratische Arbeitsweisen zu erleichtern. Parallel ergibt sich das Problem, dass auf Konsens basierende postb{\"u}rokratische Strukturen Digitalisierungsinitiativen erschweren, da diese auf eine Vielzahl von Entscheidungen angewiesen sind. Zweitens zeigt sich mit Blick auf das ambivalente Verh{\"a}ltnis von Digitalisierung und Vernetzung, dass einerseits organisationsweite Kooperation erm{\"o}glicht wird, w{\"a}hrend sich andererseits die Gefahr digitaler Widerspruchskommunikation auftut. Beim dritten Verh{\"a}ltnis zwischen Digitalisierung und Gender deutet sich das mit neuen digitalen Technologien einhergehende Potenzial f{\"u}r Gender Inklusion an, w{\"a}hrend zugleich das Problem einprogrammierter Gender Biases auftritt, die Diskriminierungen oftmals versch{\"a}rfen. Durch die Gegen{\"u}berstellung der Potenziale und Probleme wird nicht nur die Ambivalenz organisationaler Digitalisierung analysierbar und verst{\"a}ndlich, es stellt sich auch heraus, dass mit digitalen Transformationen einen doppelte Formalisierung einhergeht: Organisationen werden nicht nur mit den f{\"u}r Reformen {\"u}blichen Anpassungen der formalen Strukturen konfrontiert, sondern m{\"u}ssen zus{\"a}tzlich formale Entscheidungen zu Technikeinf{\"u}hrung und -beibehaltung treffen sowie formale L{\"o}sungen etablieren, um auf unvorhergesehene Potenziale und Probleme reagieren. Das Ziel der Dissertation ist es, eine analytisch generalisierte Heuristik an die Hand zu geben, mit deren Hilfe die Errungenschaften und Chancen digitaler Transformationen identifiziert werden k{\"o}nnen, w{\"a}hrend sich parallel ihr Verh{\"a}ltnis zu den gleichzeitig entstehenden Herausforderungen und Folgeproblemen erkl{\"a}ren l{\"a}sst.}, language = {de} } @phdthesis{Grohmann2024, author = {Grohmann, Nils-Hendrik}, title = {Strengthening the UN Human Rights Treaty Bodies}, series = {Jus Internationale et Europaeum}, journal = {Jus Internationale et Europaeum}, number = {202}, publisher = {Mohr Siebeck}, address = {T{\"u}bingen}, isbn = {978-3-16-162825-2}, issn = {1861-1893}, doi = {10.1628/978-3-16-162826-9}, pages = {XV, 315}, year = {2024}, abstract = {Nils-Hendrik Grohmann besch{\"a}ftigt sich mit dem noch andauernden St{\"a}rkungsprozess der UN-Menschenrechtsvertragsorgane. Er analysiert, welche rechtlichen Befugnisse die Aussch{\"u}sse haben, ob sie von sich aus Vorschl{\"a}ge einbringen k{\"o}nnen und inwieweit sie ihre Verfahrensweisen bisher aufeinander abgestimmt haben. Ein weiterer Schwerpunkt liegt auf der Zusammenarbeit zwischen den verschiedenen Aussch{\"u}ssen und der Frage, welche Rolle das Treffen der Vorsitzenden bei der St{\"a}rkung spielen kann.}, language = {en} } @phdthesis{AlhosseiniAlmodarresiYasin2024, author = {Alhosseini Almodarresi Yasin, Seyed Ali}, title = {Classification, prediction and evaluation of graph neural networks on online social media platforms}, doi = {10.25932/publishup-62642}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626421}, school = {Universit{\"a}t Potsdam}, pages = {xviii, 78}, year = {2024}, abstract = {The vast amount of data generated on social media platforms have made them a valuable source of information for businesses, governments and researchers. Social media data can provide insights into user behavior, preferences, and opinions. In this work, we address two important challenges in social media analytics. Predicting user engagement with online content has become a critical task for content creators to increase user engagement and reach larger audiences. Traditional user engagement prediction approaches rely solely on features derived from the user and content. However, a new class of deep learning methods based on graphs captures not only the content features but also the graph structure of social media networks. This thesis proposes a novel Graph Neural Network (GNN) approach to predict user interaction with tweets. The proposed approach combines the features of users, tweets and their engagement graphs. The tweet text features are extracted using pre-trained embeddings from language models, and a GNN layer is used to embed the user in a vector space. The GNN model then combines the features and graph structure to predict user engagement. The proposed approach achieves an accuracy value of 94.22\% in classifying user interactions, including likes, retweets, replies, and quotes. Another major challenge in social media analysis is detecting and classifying social bot accounts. Social bots are automated accounts used to manipulate public opinion by spreading misinformation or generating fake interactions. Detecting social bots is critical to prevent their negative impact on public opinion and trust in social media. In this thesis, we classify social bots on Twitter by applying Graph Neural Networks. The proposed approach uses a combination of both the features of a node and an aggregation of the features of a node's neighborhood to classify social bot accounts. Our final results indicate a 6\% improvement in the area under the curve score in the final predictions through the utilization of GNN. Overall, our work highlights the importance of social media data and the potential of new methods such as GNNs to predict user engagement and detect social bots. These methods have important implications for improving the quality and reliability of information on social media platforms and mitigating the negative impact of social bots on public opinion and discourse.}, language = {en} } @phdthesis{Antonoglou2024, author = {Antonoglou, Nikolaos}, title = {GNSS-based remote sensing: Innovative observation of key hydrological parameters in the Central Andes}, doi = {10.25932/publishup-62825}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-628256}, school = {Universit{\"a}t Potsdam}, pages = {xxii, 116}, year = {2024}, abstract = {The Central Andean region is characterized by diverse climate zones with sharp transitions between them. In this work, the area of interest is the South-Central Andes in northwestern Argentina that borders with Bolivia and Chile. The focus is the observation of soil moisture and water vapour with Global Navigation Satellite System (GNSS) remote-sensing methodologies. Because of the rapid temporal and spatial variations of water vapour and moisture circulations, monitoring this part of the hydrological cycle is crucial for understanding the mechanisms that control the local climate. Moreover, GNSS-based techniques have previously shown high potential and are appropriate for further investigation. This study includes both logistic-organization effort and data analysis. As for the prior, three GNSS ground stations were installed in remote locations in northwestern Argentina to acquire observations, where there was no availability of third-party data. The methodological development for the observation of the climate variables of soil moisture and water vapour is independent and relies on different approaches. The soil-moisture estimation with GNSS reflectometry is an approximation that has demonstrated promising results, but it has yet to be operationally employed. Thus, a more advanced algorithm that exploits more observations from multiple satellite constellations was developed using data from two pilot stations in Germany. Additionally, this algorithm was slightly modified and used in a sea-level measurement campaign. Although the objective of this application is not related to monitoring hydrological parameters, its methodology is based on the same principles and helps to evaluate the core algorithm. On the other hand, water-vapour monitoring with GNSS observations is a well-established technique that is utilized operationally. Hence, the scope of this study is conducting a meteorological analysis by examining the along-the-zenith air-moisture levels and introducing indices related to the azimuthal gradient. The results of the experiments indicate higher-quality soil moisture observations with the new algorithm. Furthermore, the analysis using the stations in northwestern Argentina illustrates the limits of this technology because of varying soil conditions and shows future research directions. The water-vapour analysis points out the strong influence of the topography on atmospheric moisture circulation and rainfall generation. Moreover, the GNSS time series allows for the identification of seasonal signatures, and the azimuthal-gradient indices permit the detection of main circulation pathways.}, language = {en} } @phdthesis{MartinezGuajardo2024, author = {Mart{\´i}nez Guajardo, Alejandro}, title = {New zwitterionic polymers for antifouling applications}, doi = {10.25932/publishup-62682}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626820}, school = {Universit{\"a}t Potsdam}, pages = {XIX, 145}, year = {2024}, abstract = {The remarkable antifouling properties of zwitterionic polymers in controlled environments are often counteracted by their delicate mechanical stability. In order to improve the mechanical stabilities of zwitterionic hydrogels, the effect of increased crosslinker densities was thus explored. In a first approach, terpolymers of zwitterionic monomer 3-[N -2(methacryloyloxy)ethyl-N,N-dimethyl]ammonio propane-1-sulfonate (SPE), hydrophobic monomer butyl methacrylate (BMA), and photo-crosslinker 2-(4-benzoylphenoxy)ethyl methacrylate (BPEMA) were synthesized. Thin hydrogel coatings of the copolymers were then produced and photo-crosslinked. Studies of the swollen hydrogel films showed that not only the mechanical stability but also, unexpectedly, the antifouling properties were improved by the presence of hydrophobic BMA units in the terpolymers. Based on the positive results shown by the amphiphilic terpolymers and in order to further test the impact that hydrophobicity has on both the antifouling properties of zwitterionic hydrogels and on their mechanical stability, a new amphiphilic zwitterionic methacrylic monomer, 3-((2-(methacryloyloxy)hexyl)dimethylammonio)propane-1-sulfonate (M1), was synthesized in good yields in a multistep synthesis. Homopolymers of M1 were obtained by free-radical polymerization. Similarly, terpolymers of M1, zwitterionic monomer SPE, and photo-crosslinker BPEMA were synthesized by free-radical copolymerization and thoroughly characterized, including its solubilities in selected solvents. Also, a new family of vinyl amide zwitterionic monomomers, namely 3-(dimethyl(2-(N -vinylacetamido)ethyl)ammonio)propane-1-sulfonate (M2), 4-(dimethyl(2-(N-vinylacetamido)ethyl)ammonio)butane-1-sulfonate (M3), and 3-(dimethyl(2-(N-vinylacetamido)ethyl)ammonio)propyl sulfate (M4), together with the new photo-crosslinker 4-benzoyl-N-vinylbenzamide (M5) that is well-suited for copolymerization with vinylamides, are introduced within the scope of the present work. The monomers are synthesized with good yields developing a multistep synthesis. Homopolymers of the new vinyl amide zwitterionic monomers are obtained by free-radical polymerization and thoroughly characterized. From the solubility tests, it is remarkable that the homopolymers produced are fully soluble in water, evidence of their high hydrophilicity. Copolymerization of the vinyl amide zwitterionic monomers, M2, M3, and M4 with the vinyl amide photo-crosslinker M5 proved to require very specific polymerization conditions. Nevertheless, copolymers were successfully obtained by free-radical copolymerization under appropriate conditions. Moreover, in an attempt to mitigate the intrinsic hydrophobicity introduced in the copolymers by the photo-crosslinkers, and based on the proven affinity of quaternized diallylamines to copolymerize with vinyl amides, a new quaternized diallylamine sulfobetaine photo-crosslinker 3-(diallyl(2-(4-benzoylphenoxy)ethyl)ammonio)propane-1-sulfonate (M6) is synthesized. However, despite a priori promising copolymerization suitability, copolymerization with the vinyl amide zwitterionic monomers could not be achieved.}, language = {en} } @phdthesis{Benson2024, author = {Benson, Lawrence}, title = {Efficient state management with persistent memory}, doi = {10.25932/publishup-62563}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-625637}, school = {Universit{\"a}t Potsdam}, pages = {xiii, 124}, year = {2024}, abstract = {Efficiently managing large state is a key challenge for data management systems. Traditionally, state is split into fast but volatile state in memory for processing and persistent but slow state on secondary storage for durability. Persistent memory (PMem), as a new technology in the storage hierarchy, blurs the lines between these states by offering both byte-addressability and low latency like DRAM as well persistence like secondary storage. These characteristics have the potential to cause a major performance shift in database systems. Driven by the potential impact that PMem has on data management systems, in this thesis we explore their use of PMem. We first evaluate the performance of real PMem hardware in the form of Intel Optane in a wide range of setups. To this end, we propose PerMA-Bench, a configurable benchmark framework that allows users to evaluate the performance of customizable database-related PMem access. Based on experimental results obtained with PerMA-Bench, we discuss findings and identify general and implementation-specific aspects that influence PMem performance and should be considered in future work to improve PMem-aware designs. We then propose Viper, a hybrid PMem-DRAM key-value store. Based on PMem-aware access patterns, we show how to leverage PMem and DRAM efficiently to design a key database component. Our evaluation shows that Viper outperforms existing key-value stores by 4-18x for inserts while offering full data persistence and achieving similar or better lookup performance. Next, we show which changes must be made to integrate PMem components into larger systems. By the example of stream processing engines, we highlight limitations of current designs and propose a prototype engine that overcomes these limitations. This allows our prototype to fully leverage PMem's performance for its internal state management. Finally, in light of Optane's discontinuation, we discuss how insights from PMem research can be transferred to future multi-tier memory setups by the example of Compute Express Link (CXL). Overall, we show that PMem offers high performance for state management, bridging the gap between fast but volatile DRAM and persistent but slow secondary storage. Although Optane was discontinued, new memory technologies are continuously emerging in various forms and we outline how novel designs for them can build on insights from existing PMem research.}, language = {en} } @phdthesis{Woebbeking2024, author = {W{\"o}bbeking, Cordula}, title = {K{\"o}rper - Karte - Text}, series = {Sanssouci - Forschungen zur Romanistik}, volume = {22}, journal = {Sanssouci - Forschungen zur Romanistik}, publisher = {Frank \& Timme}, address = {Berlin}, isbn = {978-3-7329-1016-8}, issn = {2193-9985}, school = {Universit{\"a}t Potsdam}, pages = {280}, year = {2024}, abstract = {Rabelais' Pentalogie um die Riesen Gargantua und Pantagruel spiegelt Aspekte des sich ver{\"a}ndernden Weltbildes ihrer Entstehungszeit. Diese Studie untersucht auf der Folie der Theorie des Simulakrum Schrift, wie K{\"o}rpermodellierungen und kartographisches imaginaire durch den Autor als Strategien der Verh{\"u}llung verborgener Botschaften eingesetzt werden. Sie zeigt an ausgew{\"a}hlten Beispielen des Quart Livre die Aufweichung der Grenzen von K{\"o}rper, Karte und Text und deren Durchdringung. Die Metaphorizit{\"a}t des Textes gibt Aufschluss {\"u}ber seine Autoreflexivit{\"a}t und bewirkt eine gleichsam ganzheitliche Lekt{\"u}reerfahrung. Schließlich avanciert die Fiktion in ihrer Trugbildhaftigkeit als grotesk-sinnlicher K{\"o}rper und polysemantische Karte zum Welterkl{\"a}rungsmodell, das jedoch erst dechiffriert werden muss.}, language = {de} } @phdthesis{Stange2024, author = {Stange, Maike}, title = {A study on Coronin-A and Aip1 function in motility of Dictyostelium discoideum and on Aip1 interchangeability between Dictyostelium discoideum and Arabidopsis thaliana}, doi = {10.25932/publishup-62856}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-628569}, school = {Universit{\"a}t Potsdam}, pages = {xiv, 168}, year = {2024}, abstract = {Actin is one of the most highly conserved proteins in eukaryotes and distinct actin-related proteins with filament-forming properties are even found in prokaryotes. Due to these commonalities, actin-modulating proteins of many species share similar structural properties and proposed functions. The polymerization and depolymerization of actin are critical processes for a cell as they can contribute to shape changes to adapt to its environment and to move and distribute nutrients and cellular components within the cell. However, to what extent functions of actin-binding proteins are conserved between distantly related species, has only been addressed in a few cases. In this work, functions of Coronin-A (CorA) and Actin-interacting protein 1 (Aip1), two proteins involved in actin dynamics, were characterized. In addition, the interchangeability and function of Aip1 were investigated in two phylogenetically distant model organisms. The flowering plant Arabidopsis thaliana (encoding two homologs, AIP1-1 and AIP1-2) and in the amoeba Dictyostelium discoideum (encoding one homolog, DdAip1) were chosen because the functions of their actin cytoskeletons may differ in many aspects. Functional analyses between species were conducted for AIP1 homologs as flowering plants do not harbor a CorA gene. In the first part of the study, the effect of four different mutation methods on the function of Coronin-A protein and the resulting phenotype in D. discoideum was revealed in two genetic knockouts, one RNAi knockdown and a sudden loss-of-function mutant created by chemical-induced dislocation (CID). The advantages and disadvantages of the different mutation methods on the motility, appearance and development of the amoebae were investigated, and the results showed that not all observed properties were affected with the same intensity. Remarkably, a new combination of Selection-Linked Integration and CID could be established. In the second and third parts of the thesis, the exchange of Aip1 between plant and amoeba was carried out. For A. thaliana, the two homologs (AIP1-1 and AIP1-2) were analyzed for functionality as well as in D. discoideum. In the Aip1-deficient amoeba, rescue with AIP1-1 was more effective than with AIP1-2. The main results in the plant showed that in the aip1-2 mutant background, reintroduced AIP1-2 displayed the most efficient rescue and A. thaliana AIP1-1 rescued better than DdAip1. The choice of the tagging site was important for the function of Aip1 as steric hindrance is a problem. The DdAip1 was less effective when tagged at the C-terminus, while the plant AIP1s showed mixed results depending on the tag position. In conclusion, the foreign proteins partially rescued phenotypes of mutant plants and mutant amoebae, despite the organisms only being very distantly related in evolutionary terms.}, language = {en} } @phdthesis{Rehtmeyer2024, author = {Rehtmeyer, Marcus}, title = {Die Staatskirchenvertr{\"a}ge Preußens 1929 und 1931}, series = {Rechtsgeschichtliche Forschungen}, volume = {4}, journal = {Rechtsgeschichtliche Forschungen}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-7560-1369-2}, school = {Universit{\"a}t Potsdam}, pages = {734}, year = {2024}, abstract = {Die umfangreiche rechtswissenschaftliche Studie befasst sich mit den preußischen Staatskirchenvertr{\"a}gen aus der Zeit der Weimarer Republik. Diese Vertr{\"a}ge waren H{\"o}hepunkte einer Entwicklung in Richtung gr{\"o}ßerer Freiheit und Unabh{\"a}ngigkeit der Kirchen vom Staat, die den Vorg{\"a}ngen im Reich und in anderen deutschen L{\"a}ndern teils entsprach, teils zuwiderlief. Die Entwicklung folgte keiner unverr{\"u}ckbaren Idealvorstellung {\"u}ber das Verh{\"a}ltnis von Staat und Kirche, sondern stellte sich stets als pragmatische Reaktion auf realpolitische Probleme dar. Die Staatskirchenvertr{\"a}ge selbst pr{\"a}gten die weiteren Entwicklungen in Ost und West bis zur Gegenwart.}, language = {de} } @phdthesis{You2024, author = {You, Lili}, title = {Chloroplast engineering for recombinant protein production and stress protection}, school = {Universit{\"a}t Potsdam}, pages = {133}, year = {2024}, language = {en} } @phdthesis{Littmann2024, author = {Littmann, Daniela-Christin}, title = {Large eddy simulations of the Arctic boundary layer around the MOSAiC drift track}, doi = {10.25932/publishup-62437}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624374}, school = {Universit{\"a}t Potsdam}, pages = {xii, 110}, year = {2024}, abstract = {The icosahedral non-hydrostatic large eddy model (ICON-LEM) was applied around the drift track of the Multidisciplinary Observatory Study of the Arctic (MOSAiC) in 2019 and 2020. The model was set up with horizontal grid-scales between 100m and 800m on areas with radii of 17.5km and 140 km. At its lateral boundaries, the model was driven by analysis data from the German Weather Service (DWD), downscaled by ICON in limited area mode (ICON-LAM) with horizontal grid-scale of 3 km. The aim of this thesis was the investigation of the atmospheric boundary layer near the surface in the central Arctic during polar winter with a high-resolution mesoscale model. The default settings in ICON-LEM prevent the model from representing the exchange processes in the Arctic boundary layer in accordance to the MOSAiC observations. The implemented sea-ice scheme in ICON does not include a snow layer on sea-ice, which causes a too slow response of the sea-ice surface temperature to atmospheric changes. To allow the sea-ice surface to respond faster to changes in the atmosphere, the implemented sea-ice parameterization in ICON was extended with an adapted heat capacity term. The adapted sea-ice parameterization resulted in better agreement with the MOSAiC observations. However, the sea-ice surface temperature in the model is generally lower than observed due to biases in the downwelling long-wave radiation and the lack of complex surface structures, like leads. The large eddy resolving turbulence closure yielded a better representation of the lower boundary layer under strongly stable stratification than the non-eddy-resolving turbulence closure. Furthermore, the integration of leads into the sea-ice surface reduced the overestimation of the sensible heat flux for different weather conditions. The results of this work help to better understand boundary layer processes in the central Arctic during the polar night. High-resolving mesoscale simulations are able to represent temporally and spatially small interactions and help to further develop parameterizations also for the application in regional and global models.}, language = {en} } @phdthesis{Schaumburg2024, author = {Schaumburg, Josephine}, title = {Men are not better negotiators after all!}, series = {Schriftenreihe zum Verhandlungsmanagement}, volume = {24}, journal = {Schriftenreihe zum Verhandlungsmanagement}, publisher = {Kovac}, address = {Hamburg}, isbn = {978-3-339-13798-2}, issn = {2365-7898}, school = {Universit{\"a}t Potsdam}, pages = {284}, year = {2024}, abstract = {This dissertation examines the lack of clarity in the scientific literature regarding gender and negotiation performance. It is often claimed that men negotiate better than women, yet it is simultaneously emphasized that results strongly depend on context. Through the use of qualitative methods such as content analysis and critical mixed-methods review, the research question: "Are women truly inferior negotiators compared to men?" is addressed. The study comprises a descriptive and an interpretive part. The descriptive section illuminates various interpretations of gender-specific negotiation theory among citing authors, with 67\% arguing for a general superiority of men. However, given the high variance in gender-specific differences, the focus should instead be on the context-dependency of negotiation performance. Generalized statements can be made within contexts, but not across them. In the interpretive section, several factors contributing to this misinterpretation are highlighted, including discrepancies in the definition of negotiation performance and distortions in research communication.. From a scientific perspective, this study underscores the need for a nuanced sociological analysis and warns against the one-sided acceptance of inaccurate scientific interpretations. From a practical standpoint, it amplifies the voices of women affected by biased research paradigms. Overall, the dissertation clarifies the theory of gender-specific negotiation performance and advocates for the elimination of biases in scientific discourse.}, language = {en} } @phdthesis{WindirschWoiwode2024, author = {Windirsch-Woiwode, Torben}, title = {Permafrost carbon stabilisation by recreating a herbivore-driven ecosystem}, doi = {10.25932/publishup-62424}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624240}, school = {Universit{\"a}t Potsdam}, pages = {X, 104, A-57}, year = {2024}, abstract = {With Arctic ground as a huge and temperature-sensitive carbon reservoir, maintaining low ground temperatures and frozen conditions to prevent further carbon emissions that contrib-ute to global climate warming is a key element in humankind's fight to maintain habitable con-ditions on earth. Former studies showed that during the late Pleistocene, Arctic ground condi-tions were generally colder and more stable as the result of an ecosystem dominated by large herbivorous mammals and vast extents of graminoid vegetation - the mammoth steppe. Characterised by high plant productivity (grassland) and low ground insulation due to animal-caused compression and removal of snow, this ecosystem enabled deep permafrost aggrad-ation. Now, with tundra and shrub vegetation common in the terrestrial Arctic, these effects are not in place anymore. However, it appears to be possible to recreate this ecosystem local-ly by artificially increasing animal numbers, and hence keep Arctic ground cold to reduce or-ganic matter decomposition and carbon release into the atmosphere. By measuring thaw depth, total organic carbon and total nitrogen content, stable carbon iso-tope ratio, radiocarbon age, n-alkane and alcohol characteristics and assessing dominant vegetation types along grazing intensity transects in two contrasting Arctic areas, it was found that recreating conditions locally, similar to the mammoth steppe, seems to be possible. For permafrost-affected soil, it was shown that intensive grazing in direct comparison to non-grazed areas reduces active layer depth and leads to higher TOC contents in the active layer soil. For soil only frozen on top in winter, an increase of TOC with grazing intensity could not be found, most likely because of confounding factors such as vertical water and carbon movement, which is not possible with an impermeable layer in permafrost. In both areas, high animal activity led to a vegetation transformation towards species-poor graminoid-dominated landscapes with less shrubs. Lipid biomarker analysis revealed that, even though the available organic material is different between the study areas, in both permafrost-affected and sea-sonally frozen soils the organic material in sites affected by high animal activity was less de-composed than under less intensive grazing pressure. In conclusion, high animal activity af-fects decomposition processes in Arctic soils and the ground thermal regime, visible from reduced active layer depth in permafrost areas. Therefore, grazing management might be utilised to locally stabilise permafrost and reduce Arctic carbon emissions in the future, but is likely not scalable to the entire permafrost region.}, language = {en} } @phdthesis{Schaefer2024, author = {Sch{\"a}fer, Marj{\"a}nn Helena}, title = {Untersuchungen zur Evolution der 15-Lipoxygenase (ALOX15) bei S{\"a}ugetieren und funktionelle Charakterisierung von Knock-in-M{\"a}usen mit humanisierter Reaktionsspezifit{\"a}t der 15-Lipoxygenase-2 (Alox15b)}, doi = {10.25932/publishup-62034}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-620340}, school = {Universit{\"a}t Potsdam}, pages = {XVII, 280}, year = {2024}, abstract = {Arachidons{\"a}urelipoxygenasen (ALOX-Isoformen) sind Lipid-peroxidierenden Enzyme, die bei der Zelldifferenzierung und bei der Pathogenese verschiedener Erkrankungen bedeutsam sind. Im menschlichen Genom gibt es sechs funktionelle ALOX-Gene, die als Einzelkopiegene vorliegen. F{\"u}r jedes humane ALOX-Gen gibt es ein orthologes Mausgen. Obwohl sich die sechs humanen ALOX-Isoformen strukturell sehr {\"a}hnlich sind, unterscheiden sich ihre funktionellen Eigenschaften deutlich voneinander. In der vorliegenden Arbeit wurden vier unterschiedliche Fragestellungen zum Vorkommen, zur biologischen Rolle und zur Evolutionsabh{\"a}ngigkeit der enzymatischen Eigenschaften von S{\"a}ugetier-ALOX-Isoformen untersucht: 1) Spitzh{\"o}rnchen (Tupaiidae) sind evolution{\"a}r n{\"a}her mit dem Menschen verwandt als Nagetiere und wurden deshalb als Alternativmodelle f{\"u}r die Untersuchung menschlicher Erkrankungen vorgeschlagen. In dieser Arbeit wurde erstmals der Arachidons{\"a}urestoffwechsel von Spitzh{\"o}rnchen untersucht. Dabei wurde festgestellt, dass im Genom von Tupaia belangeri vier unterschiedliche ALOX15-Gene vorkommen und die Enzyme sich hinsichtlich ihrer katalytischen Eigenschaften {\"a}hneln. Diese genomische Vielfalt, die weder beim Menschen noch bei M{\"a}usen vorhanden ist, erschwert die funktionellen Untersuchungen zur biologischen Rolle des ALOX15-Weges. Damit scheint Tupaia belangeri kein geeigneteres Tiermodel f{\"u}r die Untersuchung des ALOX15-Weges des Menschen zu sein. 2) Entsprechend der Evolutionshypothese k{\"o}nnen S{\"a}ugetier-ALOX15-Orthologe in Arachidons{\"a}ure-12-lipoxygenierende- und Arachidons{\"a}ure-15-lipoxygenierende Enzyme eingeteilt werden. Dabei exprimieren S{\"a}ugetierspezies, die einen h{\"o}heren Evolutionsgrad als Gibbons aufweisen, Arachidons{\"a}ure-15-lipoxygenierende ALOX15-Orthologe, w{\"a}hrend evolution{\"a}r weniger weit entwickelte S{\"a}ugetiere Arachidons{\"a}ure-12 lipoxygenierende Enzyme besitzen. In dieser Arbeit wurden elf neue ALOX15-Orthologe als rekombinante Proteine exprimiert und funktionell charakterisiert. Die erhaltenen Ergebnisse f{\"u}gen sich widerspruchsfrei in die Evolutionshypothese ein und verbreitern deren experimentelle Basis. Die experimentellen Daten best{\"a}tigen auch das Triadenkonzept. 3) Da humane und murine ALOX15B-Orthologe unterschiedliche funktionelle Eigenschaften aufweisen, k{\"o}nnen Ergebnisse aus murinen Krankheitsmodellen zur biologischen Rolle der ALOX15B nicht direkt auf den Menschen {\"u}bertragen werden. Um die ALOX15B-Orthologen von Maus und Mensch funktionell einander anzugleichen, wurden im Rahmen der vorliegenden Arbeit Knock-in M{\"a}use durch die In vivo Mutagenese mittels CRISPR/Cas9-Technik hergestellt. Diese exprimieren eine humanisierte Mutante (Doppelmutation von Tyrosin603Asparagins{\"a}ure+Histidin604Valin) der murinen Alox15b. Diese M{\"a}use waren lebens- und fortpflanzungsf{\"a}hig, zeigten aber geschlechtsspezifische Unterschiede zu ausgekreuzten Wildtyp-Kontrolltieren im Rahmen ihre Individualentwicklung. 4) In vorhergehenden Untersuchungen zur Rolle der ALOX15B in Rahmen der Entz{\"u}ndungsreaktion wurde eine antiinflammatorische Wirkung des Enzyms postuliert. In der vorliegenden Arbeit wurde untersucht, ob eine Humanisierung der murinen Alox15b die Entz{\"u}ndungsreaktion in zwei verschiedenen murinen Entz{\"u}ndungsmodellen beeinflusst. Eine Humanisierung der murinen Alox15b f{\"u}hrte zu einer verst{\"a}rkten Ausbildung von Entz{\"u}ndungssymptomen im induzierten Dextran-Natrium-Sulfat-Kolitismodell. Im Gegensatz dazu bewirkte die Humanisierung der Alox15b eine Abschw{\"a}chung der Entz{\"u}ndungssymptome im Freund'schen Adjuvans Pfoten{\"o}demmodell. Diese Daten deuten darauf hin, dass sich die Rolle der ALOX15B in verschiedenen Entz{\"u}ndungsmodellen unterscheidet.}, language = {de} } @phdthesis{Mueller2024, author = {M{\"u}ller, Daniel}, title = {Identification and monitoring of structures, controls, and evolution dynamics of hydrothermal systems and associated alteration through high-resolution remote sensing and in situ analysis}, doi = {10.25932/publishup-62668}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626683}, school = {Universit{\"a}t Potsdam}, pages = {205}, year = {2024}, abstract = {Volcanic hydrothermal systems are an integral part of most volcanoes and typically involve a heat source, adequate fluid supply, and fracture or pore systems through which the fluids can circulate within the volcanic edifice. Associated with this are subtle but powerful processes that can significantly influence the evolution of volcanic activity or the stability of the near-surface volcanic system through mechanical weakening, permeability reduction, and sealing of the affected volcanic rock. These processes are well constrained for rock samples by laboratory analyses but are still difficult to extrapolate and evaluate at the scale of an entire volcano. Advances in unmanned aircraft systems (UAS), sensor technology, and photogrammetric processing routines now allow us to image volcanic surfaces at the centimeter scale and thus study volcanic hydrothermal systems in great detail. This thesis aims to explore the potential of UAS approaches for studying the structures, processes, and dynamics of volcanic hydrothermal systems but also to develop methodological approaches to uncover secondary information hidden in the data, capable of indicating spatiotemporal dynamics or potentially critical developments associated with hydrothermal alteration. To accomplish this, the thesis describes the investigation of two near-surface volcanic hydrothermal systems, the El Tatio geyser field in Chile and the fumarole field of La Fossa di Vulcano (Italy), both of which are among the best-studied sites of their kind. Through image analysis, statistical, and spatial analyses we have been able to provide the most detailed structural images of both study sites to date, with new insights into the driving forces of such systems but also revealing new potential controls, which are summarized in conceptual site-specific models. Furthermore, the thesis explores methodological remote sensing approaches to detect, classify and constrain hydrothermal alteration and surface degassing from UAS-derived data, evaluated them by mineralogical and chemical ground-truthing, and compares the alteration pattern with the present-day degassing activity. A significant contribution of the often neglected diffuse degassing activity to the total amount of degassing is revealed and constrains secondary processes and dynamics associated with hydrothermal alteration that lead to potentially critical developments like surface sealing. The results and methods used provide new approaches for alteration research, for the monitoring of degassing and alteration effects, and for thermal monitoring of fumarole fields, with the potential to be incorporated into volcano monitoring routines.}, language = {en} } @phdthesis{Melliger2024, author = {Melliger, Marc Andr{\´e}}, title = {Effects of exposing renewables to the market}, school = {Universit{\"a}t Potsdam}, pages = {xi, 139}, year = {2024}, abstract = {Electricity production contributes to a significant share of greenhouse gas emissions in Europe and is thus an important driver of climate change. To fulfil the Paris Agreement, the European Union (EU) needs a rapid transition to a fully decarbonised power production system. Presumably, such a system will be largely based on renewables. So far, many EU countries have supported a shift towards renewables such as solar and wind power using support schemes, but the economic and political context is changing. Renewables are now cheaper than ever before and have become cost-competitive with conventional technologies. Therefore, European policymakers are striving to better integrate renewables into a competitive market and to increase the cost-effectiveness of the expansion of renewables. The first step was to replace previous fixed-price schemes with competitive auctions. In a second step, these auctions have become more technology-open. Finally, some governments may phase out any support for renewables and fully expose them to the competitive power market. However, such policy changes may be at odds with the need to rapidly expand renewables and meet national targets due to market characteristics and investors' risk perception. Without support, price risks are higher, and it may be difficult to meet an investor's income expectations. Furthermore, policy changes across different countries could have unexpected effects if power markets are interconnected and investors able to shift their investments. Finally, in multi-technology auctions, technologies may dominate, which can be a risk for long-term power system reliability. Therefore, in my thesis, I explore the effects of phasing out support policies for renewables, of coordinating these phase-outs across countries, and of using multi-technology designs. I expand the public policy literature about investment behaviour and policy design as well as policy change and coordination, and I further develop an agent-based model. The main questions of my thesis are what the cost and deployment effects of gradually exposing renewables to market forces would be and how coordination between countries affects investors' decisions and market prices.. In my three contributions to the academic literature, I use different methods and come to the following results. In the first contribution, I use a conjoint analysis and market simulation to evaluate the effects of phasing out support or reintroducing feed-in tariffs from the perspective of investors. I find that a phase-out leads to investment shifts, either to other still-supported technologies or to other countries that continue to offer support. I conclude that the coordination of policy changes avoids such shifts.. In the second contribution, I integrate the empirically-derived preferences from the first contribution in to an agent-based power system model of two countries to simulate the effects of ending auctions for renewables. I find that this slows the energy transition, and that cross-border effects are relevant. Consequently, continued support is necessary to meet the national renewables targets. In the third contribution, I analyse the outcome of past multi-technology auctions using descriptive statistics, regression analysis as well as case study comparisons. I find that the outcomes are skewed towards single technologies. This cannot be explained by individual design elements of the auctions, but rather results from context-specific and country-specific characteristics. Based on this, I discuss potential implications for long-term power system reliability. The main conclusions of my thesis are that a complete phase-out of renewables support would slow down the energy transition and thus jeopardize climate targets, and that multi-technology auctions may pose a risk for some countries, especially those that cannot regulate an unbalanced power plant portfolio in the long term. If policymakers decide to continue supporting renewables, they may consider adopting technology-specific auctions to better steer their portfolio. In contrast, if policymakers still want to phase out support, they should coordinate these policy changes with other countries. Otherwise, overall transition costs can be higher, because investment decisions shift to still-supported but more expensive technologies.}, language = {en} } @phdthesis{Szekely2024, author = {Sz{\´e}kely, Andr{\´a}s Csaba}, title = {Long-distance circadian coordination via a phloem-delivered mobile transcript}, school = {Universit{\"a}t Potsdam}, pages = {105}, year = {2024}, language = {en} } @phdthesis{Marx2024, author = {Marx, Carolin Valerie}, title = {Escalation of commitment in information systems projects: a cognitive-affective perspective}, doi = {10.25932/publishup-62696}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626969}, school = {Universit{\"a}t Potsdam}, pages = {174}, year = {2024}, abstract = {While information systems (IS) projects are pivotal in guiding organizational strategies and sustaining competitive advantages, they frequently overrun budgets, extend beyond timelines, and experience high failure rates. This dissertation delves into the psychological micro-foundations of human behavior - specifically cognition and emotion - in relation to a prevalent issue in IS project management: the tendency to persist with failing courses of action, also called escalation of commitment (EoC). Through a mixed-methods research approach, this study investigates the emotional and cognitive bases of decision-making during IS project escalation and its evolution over time. The results of a psychophysiological laboratory experiment provide evidence for the predictions on the role of negative and complex situational integral emotions of Cognitive Dissonance over Coping Theory and add to a better understanding of how escalation tendencies change during sequential decision-making due to cognitive learning effects. Using psychophysiological measures, including data triangulation between electrodermal and cardiovascular activity and AI-based analysis of facial micro-expressions, this research reveals physiological markers of behavioral escalation tendencies. Complementing the experiment, a qualitative analysis using free-form narration during decision-making simulations shows that decision-makers employ varied cognitive reasoning patterns to justify escalating behaviors, suggesting a sequence of four distinct cognitive phases. By integrating both qualitative and quantitative findings, this dissertation offers a comprehensive theoretical framework of how cognition and emotion shape behavioral EoC over time. I propose that escalation is a cyclical adaptation of mental models, distinguished by shifts in cognitive reasoning patterns, temporal cognition mode variations, and interactions with situational emotions and their anticipation. The primary contribution of this dissertation lies in disentangling the emotional and cognitive mechanisms that drive IS project escalation. The findings provide the basis for developing de-escalation strategies, thereby helping to improve decision-making under uncertainty. Stakeholders involved in IS projects that get "off track" should be aware of the tendency to persist with failing courses of action and the importance of the underlying emotional and cognitive dynamics.}, language = {de} } @phdthesis{Panzer2024, author = {Panzer, Marcel}, title = {Design of a hyper-heuristics based control framework for modular production systems}, doi = {10.25932/publishup-63300}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-633006}, school = {Universit{\"a}t Potsdam}, pages = {vi, 334}, year = {2024}, abstract = {Volatile supply and sales markets, coupled with increasing product individualization and complex production processes, present significant challenges for manufacturing companies. These must navigate and adapt to ever-shifting external and internal factors while ensuring robustness against process variabilities and unforeseen events. This has a pronounced impact on production control, which serves as the operational intersection between production planning and the shop- floor resources, and necessitates the capability to manage intricate process interdependencies effectively. Considering the increasing dynamics and product diversification, alongside the need to maintain constant production performances, the implementation of innovative control strategies becomes crucial. In recent years, the integration of Industry 4.0 technologies and machine learning methods has gained prominence in addressing emerging challenges in production applications. Within this context, this cumulative thesis analyzes deep learning based production systems based on five publications. Particular attention is paid to the applications of deep reinforcement learning, aiming to explore its potential in dynamic control contexts. Analysis reveal that deep reinforcement learning excels in various applications, especially in dynamic production control tasks. Its efficacy can be attributed to its interactive learning and real-time operational model. However, despite its evident utility, there are notable structural, organizational, and algorithmic gaps in the prevailing research. A predominant portion of deep reinforcement learning based approaches is limited to specific job shop scenarios and often overlooks the potential synergies in combined resources. Furthermore, it highlights the rare implementation of multi-agent systems and semi-heterarchical systems in practical settings. A notable gap remains in the integration of deep reinforcement learning into a hyper-heuristic. To bridge these research gaps, this thesis introduces a deep reinforcement learning based hyper- heuristic for the control of modular production systems, developed in accordance with the design science research methodology. Implemented within a semi-heterarchical multi-agent framework, this approach achieves a threefold reduction in control and optimisation complexity while ensuring high scalability, adaptability, and robustness of the system. In comparative benchmarks, this control methodology outperforms rule-based heuristics, reducing throughput times and tardiness, and effectively incorporates customer and order-centric metrics. The control artifact facilitates a rapid scenario generation, motivating for further research efforts and bridging the gap to real-world applications. The overarching goal is to foster a synergy between theoretical insights and practical solutions, thereby enriching scientific discourse and addressing current industrial challenges.}, language = {en} } @phdthesis{Ronneberger2024, author = {Ronneberger, Sebastian}, title = {Nanolayer Fused Deposition Modeling (NanoFDM)}, school = {Universit{\"a}t Potsdam}, pages = {170}, year = {2024}, language = {en} } @phdthesis{Rinne2024, author = {Rinne, Theresa Charlotte}, title = {The effects of nutrients on bone stem cell function and regeneration}, school = {Universit{\"a}t Potsdam}, pages = {V, 134}, year = {2024}, abstract = {Aging is associated with bone loss, which can lead to osteoporosis and high fracture risk. This coincides with the enhanced formation of bone marrow adipose tissue (BMAT), suggesting a negative effect of bone marrow adipocytes on skeletal health. Increased BMAT formation is also observed in pathologies such as obesity, type 2 diabetes and osteoporosis. However, a subset of bone marrow adipocytes forming the constitutive BMAT (cBMAT), arise early in life in the distal skeleton, contain high levels of unsaturated fatty acids and are thought to provide a physiological function. Regulated BMAT (rBMAT) forms during aging and obesity in proximal regions of the bone and contain a large proportion of saturated fatty acids. Paradoxically, BMAT accumulation is also enhanced during caloric restriction (CR), a life-span extending dietary intervention. This indicates, that different types of BMAT can form in response to opposing nutritional stimuli with potentially different functions. To this end, two types of nutritional interventions, CR and high fat diet (HFD), that are both described to induce BMAT accumulation were carried out. CR markedly increased BMAT formation in the proximal tibia and led to a higher proportion of unsaturated fatty acids, making it similar to the physiological cBMAT. Additionally, proximal and diaphyseal tibia regions displayed higher adiponectin expression. In aged mice, CR was associated with an improved trabecular bone structure. Taken together, these findings demonstrate, that the type of BMAT that forms during CR might provide beneficial effects for local bone stem/progenitor cells and metabolic health. The HFD intervention performed in this thesis showed no effect on BMAT accumulation and bone microstructure. RNA Seq analysis revealed alterations in the composition of the collagen-containing extracellular matrix (ECM). In order to investigate the effects of glucose homeostasis on osteogenesis, differentiation capacity of immortalized multipotent mesenchymal stromal cells (MSCs) and osteochondrogenic progenitor cells (OPCs) was analyzed. Insulin improved differentiation in both cell types, however, combination of with a high glucose concentration led to an impaired mineralization of the ECM. In the MSCs, this was accompanied by the formation of adipocytes, indicating negative effects of the adipocytes formed during hyperglycemic conditions on mineralization processes. However, the altered mineralization pattern and structure of the ECM was also observed in OPCs, which did not form any adipocytes, suggesting further negative effects of a hyperglycemic environment on osteogenic differentiation. In summary, the work provided in this thesis demonstrated that differentiation commitment of bone-resident stem cells can be altered through nutrient availability, specifically glucose. Surprisingly, both high nutrient supply, e.g. the hyperglycemic cell culture conditions, and low nutrient supply, e.g. CR, can induce adipogenic differentiation. However, while CR-induced adipocyte formation was associated with improved trabecular bone structure, adipocyte formation in a hyperglycemic cell-culture environment hampered mineralization. This thesis provides further evidence for the existence of different types of BMAT with specific functions.}, language = {en} } @phdthesis{Hussein2024, author = {Hussein, Mahmoud}, title = {Solvent engineering for highly-efficiency lead-free perovskite solar cells}, doi = {10.25932/publishup-63037}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630375}, school = {Universit{\"a}t Potsdam}, pages = {137}, year = {2024}, abstract = {Global warming, driven primarily by the excessive emission of greenhouse gases such as carbon dioxide into the atmosphere, has led to severe and detrimental environmental impacts. Rising global temperatures have triggered a cascade of adverse effects, including melting glaciers and polar ice caps, more frequent and intense heat waves disrupted weather patterns, and the acidification of oceans. These changes adversely affect ecosystems, biodiversity, and human societies, threatening food security, water availability, and livelihoods. One promising solution to mitigate the harmful effects of global warming is the widespread adoption of solar cells, also known as photovoltaic cells. Solar cells harness sunlight to generate electricity without emitting greenhouse gases or other pollutants. By replacing fossil fuel-based energy sources, solar cells can significantly reduce CO2 emissions, a significant contributor to global warming. This transition to clean, renewable energy can help curb the increasing concentration of greenhouse gases in the atmosphere, thereby slowing down the rate of global temperature rise. Solar energy's positive impact extends beyond emission reduction. As solar panels become more efficient and affordable, they empower individuals, communities, and even entire nations to generate electricity and become less dependent on fossil fuels. This decentralized energy generation can enhance resilience in the face of climate-related challenges. Moreover, implementing solar cells creates green jobs and stimulates technological innovation, further promoting sustainable economic growth. As solar technology advances, its integration with energy storage systems and smart grids can ensure a stable and reliable energy supply, reducing the need for backup fossil fuel power plants that exacerbate environmental degradation. The market-dominant solar cell technology is silicon-based, highly matured technology with a highly systematic production procedure. However, it suffers from several drawbacks, such as: 1) Cost: still relatively high due to high energy consumption due to the need to melt and purify silicon, and the use of silver as an electrode, which hinders their widespread availability, especially in low-income countries. 2) Efficiency: theoretically, it should deliver around 29\%; however, the efficiency of most of the commercially available silicon-based solar cells ranges from 18 - 22\%. 3) Temperature sensitivity: The efficiency decreases with the increase in the temperature, affecting their output. 4) Resource constraints: silicon as a raw material is unavailable in all countries, creating supply chain challenges. Perovskite solar cells arose in 2011 and matured very rapidly in the last decade as a highly efficient and versatile solar cell technology. With an efficiency of 26\%, high absorption coefficients, solution processability, and tunable band gap, it attracted the attention of the solar cells community. It represented a hope for cheap, efficient, and easily processable next-generation solar cells. However, lead toxicity might be the block stone hindering perovskite solar cells' market reach. Lead is a heavy and bioavailable element that makes perovskite solar cells environmentally unfriendly technology. As a result, scientists try to replace lead with a more environmentally friendly element. Among several possible alternatives, tin was the most suitable element due to its electronic and atomic structure similarity to lead. Tin perovskites were developed to alleviate the challenge of lead toxicity. Theoretically, it shows very high absorption coefficients, an optimum band gap of 1.35 eV for FASnI3, and a very high short circuit current, which nominates it to deliver the highest possible efficiency of a single junction solar cell, which is around 30.1\% according to Schockly-Quisser limit. However, tin perovskites' efficiency still lags below 15\% and is irreproducible, especially from lab to lab. This humble performance could be attributed to three reasons: 1) Tin (II) oxidation to tin (IV), which would happen due to oxygen, water, or even by the effect of the solvent, as was discovered recently. 2) fast crystallization dynamics, which occurs due to the lateral exposure of the P-orbitals of the tin atom, which enhances its reactivity and increases the crystallization pace. 3) Energy band misalignment: The energy bands at the interfaces between the perovskite absorber material and the charge selective layers are not aligned, leading to high interfacial charge recombination, which devastates the photovoltaic performance. To solve these issues, we implemented several techniques and approaches that enhanced the efficiency of tin halide perovskites, providing new chemically safe solvents and antisolvents. In addition, we studied the energy band alignment between the charge transport layers and the tin perovskite absorber. Recent research has shown that the principal source of tin oxidation is the solvent known as dimethylsulfoxide, which also happens to be one of the most effective solvents for processing perovskite. The search for a stable solvent might prove to be the factor that makes all the difference in the stability of tin-based perovskites. We started with a database of over 2,000 solvents and narrowed it down to a series of 12 new solvents that are suitable for processing FASnI3 experimentally. This was accomplished by looking into 1) the solubility of the precursor chemicals FAI and SnI2, 2) the thermal stability of the precursor solution, and 3) the potential to form perovskite. Finally, we show that it is possible to manufacture solar cells using a novel solvent system that outperforms those produced using DMSO. The results of our research give some suggestions that may be used in the search for novel solvents or mixes of solvents that can be used to manufacture stable tin-based perovskites. Due to the quick crystallization of tin, it is more difficult to deposit tin-based perovskite films from a solution than manufacturing lead-based perovskite films since lead perovskite is more often utilized. The most efficient way to get high efficiencies is to deposit perovskite from dimethyl sulfoxide (DMSO), which slows down the quick construction of the tin-iodine network that is responsible for perovskite synthesis. This is the most successful approach for achieving high efficiencies. Dimethyl sulfoxide, which is used in the processing, is responsible for the oxidation of tin, which is a disadvantage of this method. This research presents a potentially fruitful alternative in which 4-(tert-butyl) pyridine can substitute dimethyl sulfoxide in the process of regulating crystallization without causing tin oxidation to take place. Perovskite films that have been formed from pyridine have been shown to have a much-reduced defect density. This has resulted in increased charge mobility and better photovoltaic performance, making pyridine a desirable alternative for use in the deposition of tin perovskite films. The precise control of perovskite precursor crystallization inside a thin film is of utmost importance for optimizing the efficiency and manufacturing of solar cells. The deposition process of tin-based perovskite films from a solution presents difficulties due to the quick crystallization of tin compared to the more often employed lead perovskite. The optimal approach for attaining elevated efficiencies entails using dimethyl sulfoxide (DMSO) as a medium for depositing perovskite. This choice of solvent impedes the tin-iodine network's fast aggregation, which plays a crucial role in the production of perovskite. Nevertheless, this methodology is limited since the utilization of dimethyl sulfoxide leads to the oxidation of tin throughout the processing stage. In this thesis, we present a potentially advantageous alternative approach wherein 4-(tert-butyl) pyridine is proposed as a substitute for dimethyl sulfoxide in regulating crystallization processes while avoiding the undesired consequence of tin oxidation. Films of perovskite formed using pyridine as a solvent have a notably reduced density of defects, resulting in higher mobility of charges and improved performance in solar applications. Consequently, the utilization of pyridine for the deposition of tin perovskite films is considered advantageous. Tin perovskites are suffering from an apparent energy band misalignment. However, the band diagrams published in the current body of research display contradictions, resulting in a dearth of unanimity. Moreover, comprehensive information about the dynamics connected with charge extraction is lacking. This thesis aims to ascertain the energy band locations of tin perovskites by employing the kelvin probe and Photoelectron yield spectroscopy methods. This thesis aims to construct a precise band diagram for the often-utilized device stack. Moreover, a comprehensive analysis is performed to assess the energy deficits inherent in the current energetic structure of tin halide perovskites. In addition, we investigate the influence of BCP on the improvement of electron extraction in C60/BCP systems, with a specific emphasis on the energy factors involved. Furthermore, transient surface photovoltage was utilized to investigate the charge extraction kinetics of frequently studied charge transport layers, such as NiOx and PEDOT as hole transport layers and C60, ICBA, and PCBM as electron transport layers. The Hall effect, KP, and TRPL approaches accurately ascertain the p-doping concentration in FASnI3. The results consistently demonstrated a value of 1.5 * 1017 cm-3. Our research findings highlight the imperative nature of autonomously constructing the charge extraction layers for tin halide perovskites, apart from those used for lead perovskites. The crystallization of perovskite precursors relies mainly on the utilization of two solvents. The first one dissolves the perovskite powder to form the precursor solution, usually called the solvent. The second one precipitates the perovskite precursor, forming the wet film, which is a supersaturated solution of perovskite precursor and in the remains of the solvent and the antisolvent. Later, this wet film crystallizes upon annealing into a full perovskite crystallized film. In our research context, we proposed new solvents to dissolve FASnI3, but when we tried to form a film, most of them did not crystallize. This is attributed to the high coordination strength between the metal halide and the solvent molecules, which is unbreakable by the traditionally used antisolvents such as Toluene and Chlorobenzene. To solve this issue, we introduce a high-throughput antisolvent screening in which we screened around 73 selected antisolvents against 15 solvents that can form a 1M FASnI3 solution. We used for the first time in tin perovskites machine learning algorithm to understand and predict the effect of an antisolvent on the crystallization of a precursor solution in a particular solvent. We relied on film darkness as a primary criterion to judge the efficacy of a solvent-antisolvent pair. We found that the relative polarity between solvent and antisolvent is the primary factor that affects the solvent-antisolvent interaction. Based on our findings, we prepared several high-quality tin perovskite films free from DMSO and achieved an efficiency of 9\%, which is the highest DMSO tin perovskite device so far.}, language = {en} } @phdthesis{Hammel2024, author = {Hammel, Alexander}, title = {Establishing the red microalga Porphyridium purpureum as a novel platform for the production of recombinant proteins}, doi = {10.25932/publishup-63270}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-632709}, school = {Universit{\"a}t Potsdam}, pages = {ix, 159}, year = {2024}, abstract = {Microalgae have been recognized as a promising green production platform for recombinant proteins. The majority of studies on recombinant protein expression have been conducted in the green microalga C. reinhardtii. While promising improvement regarding nuclear transgene expression in this alga has been made, it is still inefficient due to epigenetic silencing, often resulting in low yields that are not competitive with other expressor organisms. Other microalgal species might be better suited for high-level protein expression, but are limited in their availability of molecular tools. The red microalga Porphyridium purpureum recently emerged as candidate for the production of recombinant proteins. It is promising in that transformation vectors are episomally maintained as autonomously replicating plasmids in the nucleus at a high copy number, thus leading to high expression values in this red alga. In this work, we expand the genetic tools for P. purpureum and investigate parameters that govern efficient transgene expression. We provide an improved transformation protocol to streamline the generation of transgenic lines in this organism. After being able to efficiently generate transgenic lines, we showed that codon usage is a main determinant of high-level transgene expression, not only at the protein level but also at the level of mRNA accumulation. The optimized expression constructs resulted in YFP accumulation up to an unprecedented 5\% of the total soluble protein. Furthermore, we designed new constructs conferring efficient transgene expression into the culture medium, simplifying purification and harvests of recombinant proteins. To further improve transgene expression, we tested endogenous promoters driving the most highly transcribed genes in P. purpureum and found minor increase of YFP accumulation. We employed the previous findings to express complex viral antigens from the hepatitis B virus and the hepatitis C virus in P. purpureum to demonstrate its feasibility as producer of biopharmaceuticals. The viral glycoproteins were successfully produced to high levels and could reach their native confirmation, indicating a functional glycosylation machinery and an appropriate folding environment in this red alga. We could successfully upscale the biomass production of transgenic lines and with that provide enough material for immunization trials in mice that were performed in collaboration. These trials showed no toxicity of neither the biomass nor the purified antigens, and, additionally, the algal-produced antigens were able to elicit a strong and specific immune response. The results presented in this work pave the way for P. purpureum as a new promising producer organism for biopharmaceuticals in the microalgal field.}, language = {en} } @phdthesis{Kiss2024, author = {Kiss, Andrea}, title = {Moss-associated bacterial and archaeal communities of northern peatlands: key taxa, environmental drivers and potential functions}, doi = {10.25932/publishup-63064}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630641}, school = {Universit{\"a}t Potsdam}, pages = {XX, 139, liv}, year = {2024}, abstract = {Moss-microbe associations are often characterised by syntrophic interactions between the microorganisms and their hosts, but the structure of the microbial consortia and their role in peatland development remain unknown. In order to study microbial communities of dominant peatland mosses, Sphagnum and brown mosses, and the respective environmental drivers, four study sites representing different successional stages of natural northern peatlands were chosen on a large geographical scale: two brown moss-dominated, circumneutral peatlands from the Arctic and two Sphagnum-dominated, acidic peat bogs from subarctic and temperate zones. The family Acetobacteraceae represented the dominant bacterial taxon of Sphagnum mosses from various geographical origins and displayed an integral part of the moss core community. This core community was shared among all investigated bryophytes and consisted of few but highly abundant prokaryotes, of which many appear as endophytes of Sphagnum mosses. Moreover, brown mosses and Sphagnum mosses represent habitats for archaea which were not studied in association with peatland mosses so far. Euryarchaeota that are capable of methane production (methanogens) displayed the majority of the moss-associated archaeal communities. Moss-associated methanogenesis was detected for the first time, but it was mostly negligible under laboratory conditions. Contrarily, substantial moss-associated methane oxidation was measured on both, brown mosses and Sphagnum mosses, supporting that methanotrophic bacteria as part of the moss microbiome may contribute to the reduction of methane emissions from pristine and rewetted peatlands of the northern hemisphere. Among the investigated abiotic and biotic environmental parameters, the peatland type and the host moss taxon were identified to have a major impact on the structure of moss-associated bacterial communities, contrarily to archaeal communities whose structures were similar among the investigated bryophytes. For the first time it was shown that different bog development stages harbour distinct bacterial communities, while at the same time a small core community is shared among all investigated bryophytes independent of geography and peatland type. The present thesis displays the first large-scale, systematic assessment of bacterial and archaeal communities associated both with brown mosses and Sphagnum mosses. It suggests that some host-specific moss taxa have the potential to play a key role in host moss establishment and peatland development.}, language = {en} } @phdthesis{Shaw2024, author = {Shaw, Vasundhara}, title = {Cosmic-ray transport and signatures in their local environment}, doi = {10.25932/publishup-62019}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-620198}, school = {Universit{\"a}t Potsdam}, pages = {143}, year = {2024}, abstract = {The origin and structure of magnetic fields in the Galaxy are largely unknown. What is known is that they are essential for several astrophysical processes, in particular the propagation of cosmic rays. Our ability to describe the propagation of cosmic rays through the Galaxy is severely limited by the lack of observational data needed to probe the structure of the Galactic magnetic field on many different length scales. This is particularly true for modelling the propagation of cosmic rays into the Galactic halo, where our knowledge of the magnetic field is particularly poor. In the last decade, observations of the Galactic halo in different frequency regimes have revealed the existence of out-of-plane bubble emission in the Galactic halo. In gamma rays these bubbles have been termed Fermi bubbles with a radial extent of ≈ 3 kpc and an azimuthal height of ≈ 6 kpc. The radio counterparts of the Fermi bubbles were seen by both the S-PASS telescopes and the Planck satellite, and showed a clear spatial overlap. The X-ray counterparts of the Fermi bubbles were named eROSITA bubbles after the eROSITA satellite, with a radial width of ≈ 7 kpc and an azimuthal height of ≈ 14 kpc. Taken together, these observations suggest the presence of large extended Galactic Halo Bubbles (GHB) and have stimulated interest in exploring the less explored Galactic halo. In this thesis, a new toy model (GHB model) for the magnetic field and non-thermal electron distribution in the Galactic halo has been proposed. The new toy model has been used to produce polarised synchrotron emission sky maps. Chi-square analysis was used to compare the synthetic skymaps with the Planck 30 GHz polarised skymaps. The obtained constraints on the strength and azimuthal height were found to be in agreement with the S-PASS radio observations. The upper, lower and best-fit values obtained from the above chi-squared analysis were used to generate three separate toy models. These three models were used to propagate ultra-high energy cosmic rays. This study was carried out for two potential sources, Centaurus A and NGC 253, to produce magnification maps and arrival direction skymaps. The simulated arrival direction skymaps were found to be consistent with the hotspots of Centaurus A and NGC 253 as seen in the observed arrival direction skymaps provided by the Pierre Auger Observatory (PAO). The turbulent magnetic field component of the GHB model was also used to investigate the extragalactic dipole suppression seen by PAO. UHECRs with an extragalactic dipole were forward-tracked through the turbulent GHB model at different field strengths. The suppression in the dipole due to the varying diffusion coefficient from the simulations was noted. The results could also be compared with an analytical analogy of electrostatics. The simulations of the extragalactic dipole suppression were in agreement with similar studies carried out for galactic cosmic rays.}, language = {en} } @phdthesis{Alawashra2024, author = {Alawashra, Mahmoud}, title = {Plasma instabilities of TeV pair beams induced by blazars}, doi = {10.25932/publishup-63013}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-630131}, school = {Universit{\"a}t Potsdam}, pages = {xxi, 130}, year = {2024}, abstract = {Relativistic pair beams produced in the cosmic voids by TeV gamma rays from blazars are expected to produce a detectable GeV-scale cascade emission missing in the observations. The suppression of this secondary cascade implies either the deflection of the pair beam by intergalactic magnetic fields (IGMFs) or an energy loss of the beam due to the electrostatic beam-plasma instability. IGMF of femto-Gauss strength is sufficient to significantly deflect the pair beams reducing the flux of secondary cascade below the observational limits. A similar flux reduction may result in the absence of the IGMF from the beam energy loss by the instability before the inverse Compton cooling. This dissertation consists of two studies about the instability role in the evolution of blazar-induced beams. Firstly, we investigated the effect of sub-fG level IGMF on the beam energy loss by the instability. Considering IGMF with correlation lengths smaller than a few kpc, we found that such fields increase the transverse momentum of the pair beam particles, dramatically reducing the linear growth rate of the electrostatic instability and hence the energy-loss rate of the pair beam. Our results show that the IGMF eliminates beam plasma instability as an effective energy-loss agent at a field strength three orders of magnitude below that needed to suppress the secondary cascade emission by magnetic deflection. For intermediate-strength IGMF, we do not know a viable process to explain the observed absence of GeV-scale cascade emission and hence can be excluded. Secondly, we probed how the beam-plasma instability feeds back on the beam, using a realistic two-dimensional beam distribution. We found that the instability broadens the beam opening angles significantly without any significant energy loss, thus confirming a recent feedback study on a simplified one-dimensional beam distribution. However, narrowing diffusion feedback of the beam particles with Lorentz factors less than 1e6 might become relevant even though initially it is negligible. Finally, when considering the continuous creation of TeV pairs, we found that the beam distribution and the wave spectrum reach a new quasi-steady state, in which the scattering of beam particles persists and the beam opening angle may increase by a factor of hundreds. This new intrinsic scattering of the cascade can result in time delays of around ten years, thus potentially mimicking the IGMF deflection. Understanding the implications on the GeV cascade emission requires accounting for inverse Compton cooling and simulating the beam-plasma system at different points in the IGM.}, language = {en} } @phdthesis{Peitz2024, author = {Peitz, Diana}, title = {Mindful Eating}, doi = {10.25932/publishup-63451}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-634515}, school = {Universit{\"a}t Potsdam}, pages = {XII, 178}, year = {2024}, abstract = {Maladaptive eating behaviors such as emotional eating, external eating, and loss-of-control eating are widespread in the general population. Moreover, they are associated to adverse health outcomes and well-known for their role in the development and maintenance of eating disorders and obesity (i.e., eating and weight disorders). Eating and weight disorders are associated with crucial burden for individuals as well as high costs for society in general. At the same time, corresponding treatments yield poor outcomes. Thus, innovative concepts are needed to improve prevention and treatment of these conditions. The Buddhist concept of mindfulness (i.e., paying attention to the present moment without judgement) and its delivery via mindfulness-based intervention programs (MBPs) has gained wide popularity in the area of maladaptive eating behaviors and associated eating and weight disorders over the last two decades. Though previous findings on their effects seem promising, the current assessment of mindfulness and its mere application via multi-component MBPs hampers to draw conclusions on the extent to which mindfulness-immanent qualities actually account for the effects (e.g., the modification of maladaptive eating behaviors). However, this knowledge is pivotal for interpreting previous effects correctly and for avoiding to cause harm in particularly vulnerable groups such as those with eating and weight disorders. To address these shortcomings, recent research has focused on the context-specific approach of mindful eating (ME) to investigate underlying mechanisms of action. ME can be considered a subdomain of generic mindfulness describing it specifically in relation to the process of eating and associated feelings, thoughts, and motives, thus including a variety of different attitudes and behaviors. However, there is no universal operationalization and the current assessment of ME suffers from different limitations. Specifically, current measurement instruments are not suited for a comprehensive assessment of the multiple facets of the construct that are currently discussed as important in the literature. This in turn hampers comparisons of different ME facets which would allow to evaluate their particular effect on maladaptive eating behaviors. This knowledge is needed to tailor prevention and treatment of associated eating and weight disorders properly and to explore potential underlying mechanisms of action which have so far been proposed mainly on theoretical grounds. The dissertation at hand aims to provide evidence-based fundamental research that contributes to our understanding of how mindfulness, more specifically its context-specific form of ME, impacts maladaptive eating behaviors and, consequently, how it could be used appropriately to enrich the current prevention and treatment approaches for eating and weight disorders in the future. Specifically, in this thesis, three scientific manuscripts applying several qualitative and quantitative techniques in four sequential studies are presented. These manuscripts were published in or submitted to three scientific peer-reviewed journals to shed light on the following questions: I. How can ME be measured comprehensively and in a reliable and valid way to advance the understanding of how mindfulness works in the context of eating? II. Does the context-specific construct of ME have an advantage over the generic concept in advancing the understanding of how mindfulness is related to maladaptive eating behaviors? III. Which ME facets are particularly useful in explaining maladaptive eating behaviors? IV. Does training a particular ME facet result in changes in maladaptive eating behaviors? To answer the first research question (Paper 1), a multi-method approach using three subsequent studies was applied to develop and validate a comprehensive self-report instrument to assess the multidimensional construct of ME - the Mindful Eating Inventory (MEI). Study 1 aimed to create an initial version of the MEI by following a three-step approach: First, a comprehensive item pool was compiled by including selected and adapted items of the existing ME questionnaires and supplementing them with items derived from an extensive literature review. Second, the preliminary item pool was complemented and checked for content validity by experts in the field of eating behavior and/or mindfulness (N = 15). Third, the item pool was further refined through qualitative methods: Three focus groups comprising laypersons (N = 16) were used as a check for applicability. Subsequently, think-aloud protocols (N = 10) served as a last check of comprehensibility and elimination of ambiguities. The resulting initial MEI version was tested in Study 2 in an online convenience sample (N = 828) to explore its factor structure using exploratory factor analysis (EFA). Results were used to shorten the questionnaire in accordance with qualitative and quantitative criteria yielding the final MEI version which encompasses 30 items. These items were assigned to seven ME facets: (1) 'Accepting and Non-attached Attitude towards one's own eating experience' (ANA), (2) 'Awareness of Senses while Eating' (ASE), (3) 'Eating in Response to awareness of Fullness' (ERF), (4) 'Awareness of eating Triggers and Motives' (ATM), (5) 'Interconnectedness' (CON), (6) 'Non-Reactive Stance' (NRS) and (7) Focused Attention on Eating' (FAE). Study 3 sought to confirm the found facets and the corresponding factor structure in an independent online convenience sample (N = 612) using confirmatory factor analysis (CFA). The study served as further indication of the assumed multidimensionality of ME (the correlational seven-factor model was shown to be superior to a single-factor model). Psychometric properties of the MEI, regarding factorial validity, internal consistency, retest-reliability, and observed criterion validity using a wide range of eating-specific and general health-related outcomes, showed the inventory to be suitable for a comprehensive, reliable and valid assessment of ME. These findings were complemented by demonstrating measurement invariance of the MEI regarding gender. In accordance with the factor structure of the MEI, Paper 1 offers an empirically-derived definition of ME, succeeding in overcoming ambiguities and problems of previous attempts at defining the construct. To answer the second and third research questions (Paper 2) a subsample of Study 2 from the MEI validation studies (N = 292) was analyzed. Incremental validity of ME beyond generic mindfulness was shown using hierarchical regression models concerning the outcome variables of maladaptive eating behaviors (emotional eating and uncontrolled eating) and nutrition behaviors (consumption of energy-dense food). Multiple regression analyses were applied to investigate the impact of the seven different ME facets (identified in Paper 1) on the same outcome variables. The following ME facets significantly contributed to explaining variance in maladaptive eating and nutrition behaviors: Accepting and Non-attached Attitude towards one`s own eating experience (ANA), Eating in Response to awareness of Fullness (ERF), the Awareness of eating Triggers and Motives (ATM), and a Non-Reactive Stance (NRS, i.e., an observing, non-impulsive attitude towards eating triggers). Results suggest that these ME facets are promising variables to consider when a) investigating potential underlying mechanisms of mindfulness and MBPs in the context of eating and b) addressing maladaptive eating behaviors in general as well as in the prevention and treatment of eating and weight disorders. To answer the fourth research question (Paper 3), a training on an isolated exercise ('9 Hunger') based on the previously identified ME facet ATM was designed to explore its particular association with changes in maladaptive eating behaviors and thus to preliminary explore one possible mechanism of action. The online study was realized using a randomized controlled trial (RCT) design. Latent Change Scores (LCS) across three measurement points (before the training, directly after the training and three months later) were compared between the intervention group (n = 211) and a waitlist control group (n = 188). Short- and longer-term effects of the training could be shown on maladaptive eating behaviors (emotional eating, external eating, loss-of-control eating) and associated outcomes (intuitive eating, ME, self-compassion, well-being). Findings serve as preliminary empirical evidence that MBPs might influence maladaptive eating behaviors through an enhanced non-judgmental awareness of and distinguishment between eating motives and triggers (i.e., ATM). This mechanism of action had previously only been hypothesized from a theoretical perspective. Since maladaptive eating behaviors are associated with eating and weight disorders, the findings can enhance our understanding of the general effects of MBPs on these conditions. The integration of the different findings leads to several suggestions of how ME might enrich different kinds of future interventions on maladaptive eating behaviors to improve health in general or the prevention and treatment of eating and weight disorders in particular. Strengths of the thesis (e.g., deliberate specific methodology, variety of designs and methods, high number of participants) are emphasized. The main limitations particularly regarding sample characteristics (e.g., higher level of formal education, fewer males, self-selected) are discussed to arrive at an outline for future studies (e.g., including multi-modal-multi-method approaches, clinical eating disorder samples and youth samples) to improve upcoming research on ME and underlying mechanisms of action of MBPs for maladaptive eating behaviors and associated eating and weight disorders. This thesis enriches current research on mindfulness in the context of eating by providing fundamental research on the core of the ME construct. Thereby it delivers a reliable and valid instrument to comprehensively assess ME in future studies as well as an operational definition of the construct. Findings on ME facet level might inform upcoming research and practice on how to address maladaptive eating behaviors appropriately in interventions. The ME skill 'Awareness of eating Triggers and Motives (ATM)' as one particular mechanism of action should be further investigated in representative community and specific clinical samples to examine the validity of the results in these groups and to justify an application of the concept to the general population as well as to subgroups with eating and weight disorders in particular. In conclusion, findings of the current thesis can be used to set future research on mindfulness, more specifically ME, and its underlying mechanism in the context of eating on a more evidence-based footing. This knowledge can inform upcoming prevention and treatment to tailor MBPs on maladaptive eating behaviors and associated eating and weight disorders appropriately.}, language = {en} } @phdthesis{BierbrauerzuBrennstein2024, author = {Bierbrauer zu Brennstein, Sophie-Charlotte von}, title = {Die Juristenausbildung in der SBZ-DDR als System durchgeformter Kontrolle}, series = {Schriften zur Rechtsgeschichte}, volume = {221}, journal = {Schriften zur Rechtsgeschichte}, publisher = {Duncker \& Humblot}, address = {Berlin}, isbn = {978-3-428-19054-6}, doi = {10.3790/978-3-428-59054-4}, pages = {377}, year = {2024}, abstract = {Law Studies in the SBZ/GDR as a System of Organized Control. Evaluation of Sources with Special Consideration of the Selection, Education and Further Training of Public Prosecutors«: Using the original sources kept in the Federal Archives, this work examines the requirements placed on law studies in the GDR and the circumstances under which legal training took place. The analysis of the archive material leads to the conclusion that the education and training of GDR lawyers was determined by a systematic political-ideological education and control to ensure the goals of the socialist party.}, language = {de} } @phdthesis{Zona2024, author = {Zona, Carlotta Isabella}, title = {Visuo-linguistic integration for thematic-role assignment across speakers}, doi = {10.25932/publishup-63185}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-631857}, school = {Universit{\"a}t Potsdam}, pages = {147}, year = {2024}, abstract = {This dissertation examines the integration of incongruent visual-scene and morphological-case information ("cues") in building thematic-role representations of spoken relative clauses in German. Addressing the mutual influence of visual and linguistic processing, the Coordinated Interplay Account (CIA) describes a mechanism in two steps supporting visuo-linguistic integration (Knoeferle \& Crocker, 2006, Cog Sci). However, the outcomes and dynamics of integrating incongruent thematic-role representations from distinct sources have been investigated scarcely. Further, there is evidence that both second-language (L2) and older speakers may rely on non-syntactic cues relatively more than first-language (L1)/young speakers. Yet, the role of visual information for thematic-role comprehension has not been measured in L2 speakers, and only limitedly across the adult lifespan. Thematically unambiguous canonically ordered (subject-extracted) and noncanonically ordered (object-extracted) spoken relative clauses in German (see 1a-b) were presented in isolation and alongside visual scenes conveying either the same (congruent) or the opposite (incongruent) thematic relations as the sentence did. 1 a Das ist der Koch, der die Braut verfolgt. This is the.NOM cook who.NOM the.ACC bride follows This is the cook who is following the bride. b Das ist der Koch, den die Braut verfolgt. This is the.NOM cook whom.ACC the.NOM bride follows This is the cook whom the bride is following. The relative contribution of each cue to thematic-role representations was assessed with agent identification. Accuracy and latency data were collected post-sentence from a sample of L1 and L2 speakers (Zona \& Felser, 2023), and from a sample of L1 speakers from across the adult lifespan (Zona \& Reifegerste, under review). In addition, the moment-by-moment dynamics of thematic-role assignment were investigated with mouse tracking in a young L1 sample (Zona, under review). The following questions were addressed: (1) How do visual scenes influence thematic-role representations of canonical and noncanonical sentences? (2) How does reliance on visual-scene, case, and word-order cues vary in L1 and L2 speakers? (3) How does reliance on visual-scene, case, and word-order cues change across the lifespan? The results showed reliable effects of incongruence of visually and linguistically conveyed thematic relations on thematic-role representations. Incongruent (vs. congruent) scenes yielded slower and less accurate responses to agent-identification probes presented post-sentence. The recently inspected agent was considered as the most likely agent ~300ms after trial onset, and the convergence of visual scenes and word order enabled comprehenders to assign thematic roles predictively. L2 (vs. L1) participants relied more on word order overall. In response to noncanonical clauses presented with incongruent visual scenes, sensitivity to case predicted the size of incongruence effects better than L1-L2 grouping. These results suggest that the individual's ability to exploit specific cues might predict their weighting. Sensitivity to case was stable throughout the lifespan, while visual effects increased with increasing age and were modulated by individual interference-inhibition levels. Thus, age-related changes in comprehension may stem from stronger reliance on visually (vs. linguistically) conveyed meaning. These patterns represent evidence for a recent-role preference - i.e., a tendency to re-assign visually conveyed thematic roles to the same referents in temporally coordinated utterances. The findings (i) extend the generalizability of CIA predictions across stimuli, tasks, populations, and measures of interest, (ii) contribute to specifying the outcomes and mechanisms of detecting and indexing incongruent representations within the CIA, and (iii) speak to current efforts to understand the sources of variability in sentence comprehension.}, language = {en} } @phdthesis{Halfpap2024, author = {Halfpap, Stefan}, title = {Integer linear programming-based heuristics for partially replicated database clusters and selecting indexes}, doi = {10.25932/publishup-63361}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-633615}, school = {Universit{\"a}t Potsdam}, pages = {iii, 185}, year = {2024}, abstract = {Column-oriented database systems can efficiently process transactional and analytical queries on a single node. However, increasing or peak analytical loads can quickly saturate single-node database systems. Then, a common scale-out option is using a database cluster with a single primary node for transaction processing and read-only replicas. Using (the naive) full replication, queries are distributed among nodes independently of the accessed data. This approach is relatively expensive because all nodes must store all data and apply all data modifications caused by inserts, deletes, or updates. In contrast to full replication, partial replication is a more cost-efficient implementation: Instead of duplicating all data to all replica nodes, partial replicas store only a subset of the data while being able to process a large workload share. Besides lower storage costs, partial replicas enable (i) better scaling because replicas must potentially synchronize only subsets of the data modifications and thus have more capacity for read-only queries and (ii) better elasticity because replicas have to load less data and can be set up faster. However, splitting the overall workload evenly among the replica nodes while optimizing the data allocation is a challenging assignment problem. The calculation of optimized data allocations in a partially replicated database cluster can be modeled using integer linear programming (ILP). ILP is a common approach for solving assignment problems, also in the context of database systems. Because ILP is not scalable, existing approaches (also for calculating partial allocations) often fall back to simple (e.g., greedy) heuristics for larger problem instances. Simple heuristics may work well but can lose optimization potential. In this thesis, we present optimal and ILP-based heuristic programming models for calculating data fragment allocations for partially replicated database clusters. Using ILP, we are flexible to extend our models to (i) consider data modifications and reallocations and (ii) increase the robustness of allocations to compensate for node failures and workload uncertainty. We evaluate our approaches for TPC-H, TPC-DS, and a real-world accounting workload and compare the results to state-of-the-art allocation approaches. Our evaluations show significant improvements for varied allocation's properties: Compared to existing approaches, we can, for example, (i) almost halve the amount of allocated data, (ii) improve the throughput in case of node failures and workload uncertainty while using even less memory, (iii) halve the costs of data modifications, and (iv) reallocate less than 90\% of data when adding a node to the cluster. Importantly, we can calculate the corresponding ILP-based heuristic solutions within a few seconds. Finally, we demonstrate that the ideas of our ILP-based heuristics are also applicable to the index selection problem.}, language = {en} } @phdthesis{Jaentsch2024, author = {J{\"a}ntsch, Christian}, title = {Lehrerinnen und Lehrer auf dem Weg zur Inklusion}, publisher = {Julius Klinkhardt}, address = {Bad Heilbrunn}, isbn = {978-3-7815-6095-6}, school = {Universit{\"a}t Potsdam}, pages = {189}, year = {2024}, language = {de} } @phdthesis{Henning2024, author = {Henning, Thorsten}, title = {Cross-sectional associations of dietary biomarker patterns with health and nutritional status}, school = {Universit{\"a}t Potsdam}, pages = {111}, year = {2024}, language = {en} } @phdthesis{Hartmann2024, author = {Hartmann, Anne}, title = {Tracing the evolution of hillslope structure and hillslope hydrological response over ten millennia in two glacial forefields of different geology}, doi = {10.25932/publishup-62862}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-628629}, school = {Universit{\"a}t Potsdam}, pages = {XVIII, 138, XLIV}, year = {2024}, abstract = {Assessing the impact of global change on hydrological systems is one of the greatest hydrological challenges of our time. Changes in land cover, land use, and climate have an impact on water quantity, quality, and temporal availability. There is a widespread consensus that, given the far-reaching effects of global change, hydrological systems can no longer be viewed as static in their structure; instead, they must be regarded as entire ecosystems, wherein hydrological processes interact and coevolve with biological, geomorphological, and pedological processes. To accurately predict the hydrological response under the impact of global change, it is essential to understand this complex coevolution. The knowledge of how hydrological processes, in particular the formation of subsurface (preferential) flow paths, evolve within this coevolution and how they feed back to the other processes is still very limited due to a lack of observational data. At the hillslope scale, this intertwined system of interactions is known as the hillslope feedback cycle. This thesis aims to enhance our understanding of the hillslope feedback cycle by studying the coevolution of hillslope structure and hillslope hydrological response. Using chronosequences of moraines in two glacial forefields developed from siliceous and calcareous glacial till, the four studies shed light on the complex coevolution of hydrological, biological, and structural hillslope properties, as well as subsurface hydrological flow paths over an evolutionary period of 10 millennia in these two contrasting geologies. The findings indicate that the contrasting properties of siliceous and calcareous parent materials lead to variations in soil structure, permeability, and water storage. As a result, different plant species and vegetation types are favored on siliceous versus calcareous parent material, leading to diverse ecosystems with distinct hydrological dynamics. The siliceous parent material was found to show a higher activity level in driving the coevolution. The soil pH resulting from parent material weathering emerges as a crucial factor, influencing vegetation development, soil formation, and consequently, hydrology. The acidic weathering of the siliceous parent material favored the accumulation of organic matter, increasing the soils' water storage capacity and attracting acid-loving shrubs, which further promoted organic matter accumulation and ultimately led to podsolization after 10 000 years. Tracer experiments revealed that the subsurface flow path evolution was influenced by soil and vegetation development, and vice versa. Subsurface flow paths changed from vertical, heterogeneous matrix flow to finger-like flow paths over a few hundred years, evolving into macropore flow, water storage, and lateral subsurface flow after several thousand years. The changes in flow paths among younger age classes were driven by weathering processes altering soil structure, as well as by vegetation development and root activity. In the older age class, the transition to more water storage and lateral flow was attributed to substantial organic matter accumulation and ongoing podsolization. The rapid vertical water transport in the finger-like flow paths, along with the conductive sandy material, contributed to podsolization and thus to the shift in the hillslope hydrological response. In contrast, the calcareous site possesses a high pH buffering capacity, creating a neutral to basic environment with relatively low accumulation of dead organic matter, resulting in a lower water storage capacity and the establishment of predominantly grass vegetation. The coevolution was found to be less dynamic over the millennia. Similar to the siliceous site, significant changes in subsurface flow paths occurred between the young age classes. However, unlike the siliceous site, the subsurface flow paths at the calcareous site only altered in shape and not in direction. Tracer experiments showed that flow paths changed from vertical, heterogeneous matrix flow to vertical, finger-like flow paths after a few hundred to thousands of years, which was driven by root activities and weathering processes. Despite having a finer soil texture, water storage at the calcareous site was significantly lower than at the siliceous site, and water transport remained primarily rapid and vertical, contributing to the flourishing of grass vegetation. The studies elucidated that changes in flow paths are predominantly shaped by the characteristics of the parent material and its weathering products, along with their complex interactions with initial water flow paths and vegetation development. Time, on the other hand, was not found to be a primary factor in describing the evolution of the hydrological response. This thesis makes a valuable contribution to closing the gap in the observations of the coevolution of hydrological processes within the hillslope feedback cycle, which is important to improve predictions of hydrological processes in changing landscapes. Furthermore, it emphasizes the importance of interdisciplinary studies in addressing the hydrological challenges arising from global change.}, language = {en} } @phdthesis{Lilienkamp2024, author = {Lilienkamp, Henning}, title = {Enhanced computational approaches for data-driven characterization of earthquake ground motion and rapid earthquake impact assessment}, doi = {10.25932/publishup-63195}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-631954}, school = {Universit{\"a}t Potsdam}, pages = {x, 145}, year = {2024}, abstract = {Rapidly growing seismic and macroseismic databases and simplified access to advanced machine learning methods have in recent years opened up vast opportunities to address challenges in engineering and strong motion seismology from novel, datacentric perspectives. In this thesis, I explore the opportunities of such perspectives for the tasks of ground motion modeling and rapid earthquake impact assessment, tasks with major implications for long-term earthquake disaster mitigation. In my first study, I utilize the rich strong motion database from the Kanto basin, Japan, and apply the U-Net artificial neural network architecture to develop a deep learning based ground motion model. The operational prototype provides statistical estimates of expected ground shaking, given descriptions of a specific earthquake source, wave propagation paths, and geophysical site conditions. The U-Net interprets ground motion data in its spatial context, potentially taking into account, for example, the geological properties in the vicinity of observation sites. Predictions of ground motion intensity are thereby calibrated to individual observation sites and earthquake locations. The second study addresses the explicit incorporation of rupture forward directivity into ground motion modeling. Incorporation of this phenomenon, causing strong, pulse like ground shaking in the vicinity of earthquake sources, is usually associated with an intolerable increase in computational demand during probabilistic seismic hazard analysis (PSHA) calculations. I suggest an approach in which I utilize an artificial neural network to efficiently approximate the average, directivity-related adjustment to ground motion predictions for earthquake ruptures from the 2022 New Zealand National Seismic Hazard Model. The practical implementation in an actual PSHA calculation demonstrates the efficiency and operational readiness of my model. In a follow-up study, I present a proof of concept for an alternative strategy in which I target the generalizing applicability to ruptures other than those from the New Zealand National Seismic Hazard Model. In the third study, I address the usability of pseudo-intensity reports obtained from macroseismic observations by non-expert citizens for rapid impact assessment. I demonstrate that the statistical properties of pseudo-intensity collections describing the intensity of shaking are correlated with the societal impact of earthquakes. In a second step, I develop a probabilistic model that, within minutes of an event, quantifies the probability of an earthquake to cause considerable societal impact. Under certain conditions, such a quick and preliminary method might be useful to support decision makers in their efforts to organize auxiliary measures for earthquake disaster response while results from more elaborate impact assessment frameworks are not yet available. The application of machine learning methods to datasets that only partially reveal characteristics of Big Data, qualify the majority of results obtained in this thesis as explorative insights rather than ready-to-use solutions to real world problems. The practical usefulness of this work will be better assessed in the future by applying the approaches developed to growing and increasingly complex data sets.}, language = {en} } @phdthesis{Siebler2024, author = {Siebler, Lara}, title = {Identifying novel regulators of heat stress memory in Arabidopsis thaliana}, doi = {10.25932/publishup-63447}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-634477}, school = {Universit{\"a}t Potsdam}, pages = {135}, year = {2024}, abstract = {Heat stress (HS) is a major abiotic stress that negatively affects plant growth and productivity. However, plants have developed various adaptive mechanisms to cope with HS, including the acquisition and maintenance of thermotolerance, which allows them to respond more effectively to subsequent stress episodes. HS memory includes type II transcriptional memory which is characterized by enhanced re-induction of a subset of HS memory genes upon recurrent HS. In this study, new regulators of HS memory in A. thaliana were identified through the characterization of rein mutants. The rein1 mutant carries a premature stop in CYCLIN-DEPENDENT-KINASE 8 (CDK8) which is part of the cyclin kinase module of the Mediator complex. Rein1 seedlings show impaired type II transcriptional memory in multiple heat-responsive genes upon re-exposure to HS. Additionally, the mutants exhibit a significant deficiency in HS memory at the physiological level. Interaction studies conducted in this work indicate that CDK8 associates with the memory HEAT SHOCK FACTORs HSAF2 and HSFA3. The results suggest that CDK8 plays a crucial role in HS memory in plants together with other memory HSFs, which may be potential targets of the CDK8 kinase function. Understanding the role and interaction network of the Mediator complex during HS-induced transcriptional memory will be an exciting aspect of future HS memory research. The second characterized mutant, rein2, was selected based on its strongly impaired pAPX2::LUC re-induction phenotype. In gene expression analysis, the mutant revealed additional defects in the initial induction of HS memory genes. Along with this observation, basal thermotolerance was impaired similarly as HS memory at the physiological level in rein2. Sequencing of backcrossed bulk segregants with subsequent fine mapping narrowed the location of REIN2 to a 1 Mb region on chromosome 1. This interval contains the At1g65440 gene, which encodes the histone chaperone SPT6L. SPT6L interacts with chromatin remodelers and bridges them to the transcription machinery to regulate nucleosome and Pol II occupancy around the transcriptional start site. The EMS-induced missense mutation in SPT6L may cause altered HS-induced gene expression in rein2, possibly triggered by changes in the chromatin environment resulting from altered histone chaperone function. Expanding research on screen-derived factors that modify type II transcriptional memory has the potential to enhance our understanding of HS memory in plants. Discovering connections between previously identified memory factors will help to elucidate the underlying network of HS memory. This knowledge can initiate new approaches to improve heat resilience in crops.}, language = {en} } @phdthesis{Freimuth2024, author = {Freimuth, Nina}, title = {Elucidating the suppression of root hair formation by a member of a novel, short ENTH protein family in Arabidopsis thaliana}, doi = {10.25932/publishup-63499}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-634994}, school = {Universit{\"a}t Potsdam}, pages = {XIII, 156}, year = {2024}, abstract = {This work analyzed functional and regulatory aspects of the so far little characterized EPSIN N-terminal Homology (ENTH) domain-containing protein EPSINOID2 in Arabidopsis thaliana. ENTH domain proteins play accessory roles in the formation of clathrin-coated vesicles (CCVs) (Zouhar and Sauer 2014). Their ENTH domain interacts with membranes and their typically long, unstructured C-terminus contains binding motifs for adaptor protein complexes and clathrin itself. There are seven ENTH domain proteins in Arabidopsis. Four of them possess the canonical long C-terminus and participate in various, presumably CCV-related intracellular transport processes (Song et al. 2006; Lee et al. 2007; Sauer et al. 2013; Collins et al. 2020; Heinze et al. 2020; Mason et al. 2023). The remaining three ENTH domain proteins, however, have severely truncated C-termini and were termed EPSINOIDs (Zouhar and Sauer 2014; Freimuth 2015). Their functions are currently unclear. Preceding studies focusing on EPSINOID2 indicated a role in root hair formation: epsinoid2 T DNA mutants exhibited an increased root hair density and EPSINOID2-GFP was specifically located in non-hair cell files in the Arabidopsis root epidermis (Freimuth 2015, 2019). In this work, it was clearly shown that loss of EPSINOID2 leads to an increase in root hair density through analyses of three independent mutant alleles, including a newly generated CRISPR/Cas9 full deletion mutant. The ectopic root hairs emerging from non-hair positions in all epsinoid2 mutant alleles are most likely not a consequence of altered cell fate, because extensive genetic analyses placed EPSINOID2 downstream of the established epidermal patterning network. Thus, EPSINOID2 seems to act as a cell autonomous inhibitor of root hair formation. Attempts to confirm this hypothesis by ectopically overexpressing EPSINOID2 led to the discovery of post-transcriptional and -translational regulation through different mechanisms. One involves the little characterized miRNA844-3p. Interference with this pathway resulted in ectopic EPSINOID2 overexpression and decreased root hair density, confirming it as negative factor in root hair formation. A second mechanism likely involves proteasomal degradation. Treatment with proteasomal inhibitor MG132 led to EPSINOID2-GFP accumulation, and a KEN box degron motif was identified in the EPSINOID2 sequence associated with degradation through a ubiquitin/proteasome-dependent pathway. In line with a tight dose regulation, genetic analyses of all three mutant alleles indicate that EPSINOID2 is haploinsufficient. Lastly, it was revealed that, although EPSINOID2 promoter activity was found in all epidermal cells, protein accumulation was observed in N-cells only, hinting at yet another layer of regulation.}, language = {en} } @phdthesis{Aue2024, author = {Aue, Lars}, title = {Cyclone impacts on sea ice in the Atlantic Arctic Ocean}, doi = {10.25932/publishup-63445}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-634458}, school = {Universit{\"a}t Potsdam}, pages = {VIII, 131}, year = {2024}, abstract = {The Arctic is the hot spot of the ongoing, global climate change. Over the last decades, near-surface temperatures in the Arctic have been rising almost four times faster than on global average. This amplified warming of the Arctic and the associated rapid changes of its environment are largely influenced by interactions between individual components of the Arctic climate system. On daily to weekly time scales, storms can have major impacts on the Arctic sea-ice cover and are thus an important part of these interactions within the Arctic climate. The sea-ice impacts of storms are related to high wind speeds, which enhance the drift and deformation of sea ice, as well as to changes in the surface energy budget in association with air mass advection, which impact the seasonal sea-ice growth and melt. The occurrence of storms in the Arctic is typically associated with the passage of transient cyclones. Even though the above described mechanisms how storms/cyclones impact the Arctic sea ice are in principal known, there is a lack of statistical quantification of these effects. In accordance with that, the overarching objective of this thesis is to statistically quantify cyclone impacts on sea-ice concentration (SIC) in the Atlantic Arctic Ocean over the last four decades. In order to further advance the understanding of the related mechanisms, an additional objective is to separate dynamic and thermodynamic cyclone impacts on sea ice and assess their relative importance. Finally, this thesis aims to quantify recent changes in cyclone impacts on SIC. These research objectives are tackled utilizing various data sets, including atmospheric and oceanic reanalysis data as well as a coupled model simulation and a cyclone tracking algorithm. Results from this thesis demonstrate that cyclones are significantly impacting SIC in the Atlantic Arctic Ocean from autumn to spring, while there are mostly no significant impacts in summer. The strength and the sign (SIC decreasing or SIC increasing) of the cyclone impacts strongly depends on the considered daily time scale and the region of the Atlantic Arctic Ocean. Specifically, an initial decrease in SIC (day -3 to day 0 relative to the cyclone) is found in the Greenland, Barents and Kara Seas, while SIC increases following cyclones (day 0 to day 5 relative to the cyclone) are mostly limited to the Barents and Kara Seas. For the cold season, this results in a pronounced regional difference between overall (day -3 to day 5 relative to the cyclone) SIC-decreasing cyclone impacts in the Greenland Sea and overall SIC-increasing cyclone impacts in the Barents and Kara Seas. A cyclone case study based on a coupled model simulation indicates that both dynamic and thermodynamic mechanisms contribute to cyclone impacts on sea ice in winter. A typical pattern consisting of an initial dominance of dynamic sea-ice changes followed by enhanced thermodynamic ice growth after the cyclone passage was found. This enhanced ice growth after the cyclone passage most likely also explains the (statistical) overall SIC-increasing effects of cyclones in the Barents and Kara Seas in the cold season. Significant changes in cyclone impacts on SIC over the last four decades have emerged throughout the year. These recent changes are strongly varying from region to region and month to month. The strongest trends in cyclone impacts on SIC are found in autumn in the Barents and Kara Seas. Here, the magnitude of destructive cyclone impacts on SIC has approximately doubled over the last four decades. The SIC-increasing effects following the cyclone passage have particularly weakened in the Barents Sea in autumn. As a consequence, previously existing overall SIC-increasing cyclone impacts in this region in autumn have recently disappeared. Generally, results from this thesis show that changes in the state of the sea-ice cover (decrease in mean sea-ice concentration and thickness) and near-surface air temperature are most important for changed cyclone impacts on SIC, while changes in cyclone properties (i.e. intensity) do not play a significant role.}, language = {en} } @phdthesis{Kuhrts, author = {Kuhrts, Lucas}, title = {The effect of Polycations on the Formation of Magnetite Nanoparticles}, address = {Potsdam}, school = {Universit{\"a}t Potsdam}, pages = {VIII, 99}, abstract = {Nanoparticles of magnetite (Fe3O4) are envisioned to find used in diverse applications, ranging from magnetic data storage, inks, ferrofluids as well as in magnetic resonance imaging, drug delivery, and hyperthermia cancer treatment. Their magnetic properties strongly depend on their size and morphology, two properties that can be synthetically controlled. Achieving appropriate control under soft chemical conditions has so far remained a challenging endeavor. One proven way of exerting this desired control has been using a biomimetic approach that emulates the proteome of magnetotactic bacteria by adding poly-L-arginine in the co- precipitation of ferrous and ferric chloride. The objective of the work presented here is to understand the impact of this polycation on the formation mechanism of magnetite and, through rational design, to enhance the control we can exert on magnetite nanoparticle size and morphology. We developed a SAXS setup to temporally and structurally resolve the formation of magnetite in the presence of poly-L-arginine in situ. Using analytical scattering models, we were able to separate the scattering contribution of a low-density 5 nm iron structure from the contribution of the growing nanoparticles. We identified that the low-density iron structure is a metastable precursor to the magnetite particles and that it is electrostatically stabilized by poly-L-arginine. In a process analogous to biomineralization, the presence of the charged macromolecule thus shifts the reaction mechanism from a thermodynamically controlled one to a kinetically controlled one. We identify this shift in reactions mechanism as the cornerstone of the proposed mechanism and as the crucial step in the paradigm of this extraordinary nanoparticle morphology and size control. Based on SAXS data, theoretical considerations suggest that an observed morphological transition between spherical, solid, and sub-structured mesocrystalline magnetite nanoparticles is induced through a pH-driven change in the wettability of the nanoparticle surface. With these results, we further demonstrate that SAXS can be an invaluable tool for investigating nanoparticle formation. We were able to change particle morphology from spherically solid particles to sub-structured mesocrystals merely by changing the precipitation pH. Improving the synthesis sustainability by substituting poly-L-arginine with renewable, polysaccharide-based polycations produced at the metric ton scale, we demonstrated that the ability to alter the reaction mechanism of magnetite can be generically attributed to the presence of polycations. Through meticulous analysis and the understanding of the formation mechanism, we were able to exert precise control over particle size and morphology, by adapting crucial synthesis parameters. We were thus able to grow mesocrystals up to 200 nm and solid nanocrystals of 100 nm by adding virtually any strong polycation. We further found a way to produce stable single domain magnetite at only slightly increased alkalinity, as magnetotactic bacteria do it. Thus through the understanding of the biological system, the consecutive biomimetic synthesis of magnetite and the following understanding of the mechanism involved in the in vitro synthesis, we managed to improve the synthetic control over the co-precipitation of magnetite, coming close biomineralization of magnetite in magnetotactic bacteria. Polyanions, in both natural as well as in synthetic systems, have been in the spotlight of recent research, yet our work shows the pivotal influence polycations have on the nucleation of magnetite. This work will contribute significantly to our ability to tailor magnetite nanoparticle size and morphology; in addition, we presume it will provide us with a model system for studying biomineralization of magnetite in vitro, putting the spotlight on the important influence of polycations, which have not had the scientific attention they deserve.}, language = {en} } @phdthesis{Kietzmann, author = {Kietzmann, Uwe}, title = {Change leadership}, school = {Universit{\"a}t Potsdam}, pages = {105, XXXVI}, language = {de} } @phdthesis{Lange, author = {Lange, Rainette}, title = {Erz{\"a}hlen vom Umbruch}, series = {Zeithistorische Studien ; 61}, journal = {Zeithistorische Studien ; 61}, publisher = {B{\"o}hlau}, address = {K{\"o}ln}, isbn = {978-3-412-51849-3}, pages = {267}, language = {de} } @phdthesis{Tempel, author = {Tempel, Małgorzata}, title = {Imagologische Probleme der {\"U}bersetzung}, series = {Studien zur Germanistik, Skandinavistik und {\"U}bersetzungskultur ; 22}, journal = {Studien zur Germanistik, Skandinavistik und {\"U}bersetzungskultur ; 22}, publisher = {Peter Lang}, address = {Berlin}, isbn = {978-3-631-80791-0}, doi = {10.3726/b16481}, school = {Universit{\"a}t Potsdam}, pages = {277}, language = {de} } @phdthesis{Goa, author = {Goa, Yang}, title = {Chloroplast translational regulation during acclimation to low temperature and impact of knockouts of non-essential chloroplast tRNAs on ribosome behavior}, school = {Universit{\"a}t Potsdam}, pages = {124}, language = {en} } @phdthesis{Schulz, author = {Schulz, Patrick}, title = {Die R{\"u}ckabwicklung im Ertragsteuerrecht}, series = {Steuerwissenschaftliche Schriften}, journal = {Steuerwissenschaftliche Schriften}, number = {70}, edition = {1. Aufl.}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-5958-3}, doi = {10.5771/9783748900870}, pages = {270}, abstract = {Das Ertragsteuerrecht l{\"a}sst ausdr{\"u}ckliche Regelungen vermissen, welche steuerlichen Folgen sich ergeben, wenn ein ertragsteuerrelevanter Sachverhalt sp{\"a}ter wieder r{\"u}ckg{\"a}ngig gemacht wird. Es bleibt deshalb den Rechtsanwendern {\"u}berlassen, die Fragen {\"u}ber die steuerliche Behandlung von R{\"u}ckg{\"a}ngigmachungen zu beantworten. Dabei werden die von der Rechtsprechung gefundenen L{\"o}sungen in der Literatur immer wieder kritisiert. Die Arbeit untersucht, ob und inwieweit die Kritik an der Rechtsprechung der Finanzgerichte in Zusammenhang mit R{\"u}ckabwicklungen, als besondere Form der R{\"u}ckg{\"a}ngigmachung, berechtigt ist. Dazu wird zun{\"a}chst dargestellt, unter welchen Voraussetzungen die R{\"u}ckabwicklung eines ertragsteuerrelevanten Vorgangs vorliegt und welche steuerliche Folgen ebenjene ausl{\"o}st. Die Arbeit schließt mit der Forderung nach einer „korrespondierenden Besteuerung" von R{\"u}ckabwicklungen und der damit verbundenen teilweisen Abkehr von der derzeitigen Rechtsprechung der Finanzgerichte.}, language = {de} } @phdthesis{Guenther, author = {G{\"u}nther, Erika}, title = {Intracellular processes in magnetotactic bacteria studied by optical tools}, school = {Universit{\"a}t Potsdam}, pages = {113}, language = {en} } @phdthesis{Meier, author = {Meier, Andrea Elisabeth}, title = {Pr{\"a}senz des Augen-Blicks}, series = {Untersuchung zum Pr{\"a}senz-Begriff in der Performance-Kunst von Marina Abramovic}, journal = {Untersuchung zum Pr{\"a}senz-Begriff in der Performance-Kunst von Marina Abramovic}, school = {Universit{\"a}t Potsdam}, language = {de} } @phdthesis{Trifonov, author = {Trifonov, Stefan}, title = {Diving Deeper into the Activities and Goals in the Entrepreneurial Process of Internet-enabled Startups}, series = {an activity-based Perspective in the Context of Accelerator Programs}, journal = {an activity-based Perspective in the Context of Accelerator Programs}, school = {Universit{\"a}t Potsdam}, language = {en} } @phdthesis{Jacobi, author = {Jacobi, Florian}, title = {Steuerhinterziehung durch aktives Tun und durch Unterlassen}, series = {Neue juristische Beitr{\"a}ge ; 126}, journal = {Neue juristische Beitr{\"a}ge ; 126}, publisher = {utzverlag}, address = {M{\"u}nchen}, isbn = {978-3-8316-4791-0}, school = {Universit{\"a}t Potsdam}, pages = {170}, abstract = {Die h{\"o}chstrichterliche Rechtsprechung zum Tatbestand der Steuerhinterziehung enth{\"a}lt - soweit ersichtlich - keine n{\"a}heren Ausf{\"u}hrungen zur Verhaltenseinordnung als Tun oder Unterlassen. Somit gaben nicht praktische Anwendungsprobleme Anlass f{\"u}r die Untersuchung. Es wurde vielmehr das Ziel verfolgt, die Frage nach der Abgrenzung der Tatbestands­alternativen der Steuerhinterziehung einer dogmatisch fundierten L{\"o}sung zuzuf{\"u}hren bzw. das strukturelle Verh{\"a}ltnis der Tatbestandsalternativen des Hinterziehungstatbestandes zu beschreiben. Der Autor gelangt zum Ergebnis, dass die Abgrenzung der Verhaltensalternativen mit Hilfe des sog. modifizierten Kausalit{\"a}tskriteriums zu erfolgen hat, und zeigt, dass der Begehungstatbestand - der auch durch Unterlassen verwirklicht werden kann - einen Großteil der steuerrechtlichen Delinquenz erfasst.}, language = {de} } @phdthesis{Bloch, author = {Bloch, Yanina}, title = {UN-Women}, series = {Internationales Recht der Gegenwart ; 4}, journal = {Internationales Recht der Gegenwart ; 4}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-5621-6}, pages = {324}, abstract = {UN Women - eine erfolgreiche Reform innerhalb der Vereinten Nationen f{\"u}r das Anliegen Geschlechtergleichberechtigung oder eine weitere verpasste Chance? Eine erste Bilanz nach 7 Jahren zeigt, wo erste Erfolge zu verzeichnen sind und welche H{\"u}rden vielleicht un{\"u}berwindbar zum Scheitern der neuen Institution f{\"u}r Frauen- und Gleichstellungsfragen beitragen werden. Um zu begreifen, welche Neuerungen durch die Gr{\"u}ndung von UN Women in das System der Vereinten Nationen eingef{\"u}hrt wurden, hilft dabei ein Blick zur{\"u}ck in die institutionelle und politische Geschichte der Vereinten Nationen, um die Entwicklung von Frauenrechten seit Gr{\"u}ndung der UN zu beleuchten. Ferner wird der Status-quo des V{\"o}lkerrechts im Hinblick auf die Rechte und den Schutz von Frauen ausf{\"u}hrlich auf existierende Schw{\"a}chen bzw. L{\"u}cken hin analysiert. Schlussendlich gibt die Verfasserin eine konkrete Bewertung bez{\"u}glich der institutionellen, politischen und rechtlichen Fortschritte und bestehenden M{\"a}ngel sowie eigene Handlungsempfehlungen ab.}, language = {de} } @phdthesis{Ulbricht, author = {Ulbricht, Juliane}, title = {Gewalt und Mobbing an Schulen als Thema in der Lehrerausbildung}, publisher = {wvb Wissenschaftlicher Verlag Berlin}, address = {Berlin}, isbn = {978-3-96138-098-5}, school = {Universit{\"a}t Potsdam}, pages = {421}, abstract = {Wie werden angehende Lehrpersonen durch die Lehrerausbildung auf das Handeln in schulischen Gewalt- und Mobbing­situationen vorbereitet? {\"U}ber welche Kompetenzen im Um­gang mit Gewalt und Mobbing an Schulen verf{\"u}gen angehende Lehrpersonen? Trotz der zentralen Rolle von Lehrpersonen bei der Pr{\"a}vention und Intervention von Gewalt und Mobbing lieferte die Forschung auf diese Fragen bislang kaum Antworten. Die vorliegende Studie untersucht subjektive Kompetenzeinsch{\"a}tzungen von Lehramtsstudierenden und Referendaren im Umgang mit Gewalt und Mobbing an Schulen und identifiziert individuelle und institutionelle Einflussfaktoren f{\"u}r deren Erwerb in der Lehrerausbildung. Aus den Ergebnissen werden Empfehlungen f{\"u}r die F{\"o}rderung entsprechender Handlungskompetenzen sowie eine Strategie zur nachhaltigen Implementierung von Gewaltpr{\"a}vention und -intervention als Querschnittsthema in alle Phasen der Lehrerbildung abgeleitet. Den Kern bildet dabei die Entwicklung eines Curriculums „Gewaltpr{\"a}vention und -intervention".}, language = {de} } @phdthesis{ColemanMacGregorofInneregny, author = {Coleman Mac Gregor of Inneregny, Verena}, title = {Cell-autonomous and cell-non-autonomous adaptation to skeletal muscle mitochondrial stress}, school = {Universit{\"a}t Potsdam}, pages = {86}, language = {en} } @phdthesis{Mahmoudi, author = {Mahmoudi, Mahdi Hedayat}, title = {New applications of the edge calculus}, school = {Universit{\"a}t Potsdam}, pages = {126}, language = {en} } @phdthesis{Gulati, author = {Gulati, Sneha}, title = {Impact of individual and combined abiotic and biotic stress on plant performance and bacterial root microbiota of tomato}, address = {Potsdam}, school = {Universit{\"a}t Potsdam}, pages = {XV, 134}, abstract = {Nutzpflanzen sind zunehmend mit sowohl individuellem als auch kombiniertem abiotischem und biotischem Stress konfrontiert, die Wachstum und Ertrag stark beeintr{\"a}chtigen. Pflanzen sind mit einer großen Anzahl an Mikroorganismen assoziiert, die sowohl n{\"u}tzlich als auch pathogen wirken k{\"o}nnen. Aufgrund der positiven Wirkung von n{\"u}tzlichen Mikroorganismen auf Wachstum und Gesundheit von Pflanzen ist dieses Potenzial in nachhaltigen Pflanzenproduktionssystemen zu nutzen. Kenntnisse dar{\"u}ber, wie individueller und kombinierter Stress die Leistung der Pflanze einschließlich deren Mikrobiom beeinflussen, sind derzeit begrenzt. Es stellt sich daher die Frage, wie abiotische Bedingungen (Salzstress, Trockenheit) insbesondere in Kombination mit biotischem Stress (Verticillium dahliae, Fusarium oxysporum) die Mikrobiota der Wurzel beeinflussen und dies die Leistung der Pflanze. Ziel dieser Arbeit war es, das Verst{\"a}ndnis der Auswirkungen von individuellem und kombiniertem biotischem und abiotischem Stress auf die endophytische Mikrobiota der Wurzel und die Leistung der Pflanze zu verbessern. Die Untersuchungen erfolgen an der wirtschaftlich bedeutenden gartenbaulichen Kultur Tomate. Die Struktur der bakteriellen endophytischen Mikrobiota der Tomatenwurzel in Abh{\"a}ngigkeit von individuellem und kombiniertem abiotischem und biotischem Stress wurde mit kulturunabh{\"a}ngigen und -abh{\"a}ngigen Methoden analysiert. Die Ergebnisse der Analysen mittels beider Methoden zeigen, dass sowohl abiotische als auch biotische Stressbedingungen signifikant die Struktur der endophytischen Mikrobiota der Wurzel ver{\"a}ndern und sich dies auf die Produktivit{\"a}t der Pflanze auswirkt. Insgesamt wurden 683 kultivierbare bakterielle Endophyten hinsichtlich ihrer pflanzenwachstumsf{\"o}rdernden (PGP) Eigenschaften in in vitro und in vivo charakterisiert. Im Ergebnis kulturabh{\"a}ngiger Analysen wurden Endophyten mit wiederholt positiver Wirkung auf das Pflanzenwachstum von Tomate unter individuellem und kombiniertem abiotischen und biotischen Stress selektiert. Die Behandlung von Pflanzen mit diesen n{\"u}tzlichen Mikroorganismen reduzierte den negativen Einfluss von Stress auf das Pflanzenwachstum. Im Weiteren k{\"o}nnen diese n{\"u}tzlichen Mikroorganismen zu Produkten f{\"u}r die Nutzung in nachhaltigen Pflanzensystemen entwickelt werden. Dazu sind jedoch weitere Untersuchungen insbesondere unter Feldbedingungen notwendig. Zuk{\"u}nftige Arbeiten sollten sich zudem auf die Verbesserung des Verst{\"a}ndnisses der Funktionen von Endophyten in der Wurzel konzentrieren. Diese Kenntnisse k{\"o}nnten die Entwicklung neuer Strategien f{\"u}r den Pflanzenschutz unterst{\"u}tzen.}, language = {en} } @phdthesis{ColemanMacGregorofInneregny, author = {Coleman Mac Gregor of Inneregny, Charles Dominic}, title = {Rolle von mPGES1-abh{\"a}ngig gebildetem Prostaglandin E2 bei der Ausbildung von Insulinresistenz und nicht-alkoholischer Fettlebererkrankung durch die Modulation der Funktion von Lebermakrophagen}, school = {Universit{\"a}t Potsdam}, pages = {183}, abstract = {Eine St{\"o}rung des Leberstoffwechsels durch die Ausbildung einer Insulinresistenz kann zu Folgeerkrankungen wie der nicht alkoholischen Fettlebererkrankung (NAFLD) bis hin zur Steatohepatitis (NASH) und zur Entwicklung eines Diabetes Typ II f{\"u}hren. Am Krankheitsverlauf sind residente (Kupfferzellen) sowie infiltrierende Makrophagen beteiligt, die durch inflammatorische Stimuli aktiviert werden und zur Progression von Lebererkrankungen f{\"u}hren k{\"o}nnen. Im Rahmen dieser Arbeit wurde die Rolle von mPGES1-abh{\"a}ngig gebildetem Prostaglandin E2 (PGE2) an der Modulation von aktivierten Lebermakrophagen untersucht. Dazu wurden Kupfferzellen und Peritonealmakrophagen (als Modell f{\"u}r infiltrierende Makrophagen) aus Wildtyp und mPGES1-defizienten M{\"a}usen isoliert. Beide Makrophagen­populationen wurden in Zellkulturversuchen mit Lipopolysacchariden (LPS) aktiviert und auf ihre PGE2-Synthese, Genexpression und Sekretion von verschiedenen Cytokinen hin untersucht. Die beiden Makrophagenpopulationen unterschieden sich hinsichtlich der PGE2-Synthese bei mPGSE1-Defizienz. W{\"a}hrend bei Peritonealmakrophagen die LPS-abh{\"a}ngige PGE2-Synthese bei Abwesenheit der mPGES1 fast vollst{\"a}ndig reprimiert war, war bei Kupfferzellen nur eine 25\%ige Abnahme zu verzeichnen. Die postulierte selbstverst{\"a}rkende R{\"u}ckkopplungsschleife von PGE2 im Hinblick auf seine eigene Synthese konnte in isolierten Peritonealmakrophagen, nicht jedoch in Kupfferzellen, best{\"a}tigt werden. In Kupfferzellen f{\"u}hrte exogenes PGE2 ferner zu einer Repression von den pro-inflammatorischen Cytokinen TNFα und IL-1β und f{\"u}r endogenes PGE2 konnte in diesem Zelltyp kein Effekt festgestellt werden. In Peritonealmakrophagen konnte hingegen auch f{\"u}r endogenes PGE2 eine reprimierende Wirkung auf die Expression von TNFα beobachtet werden. Das ist eventuell auf eine h{\"o}here Sensitivit{\"a}t gegen{\"u}ber PGE2 von Peritonealmakrophagen im Vergleich zu Kupfferzellen zur{\"u}ckzuf{\"u}hren. PGE2 wirkte unter den gew{\"a}hlten Versuchsbedingungen in vitro somit eher anti-inflammatorisch. Cholesterolkristalle induzierten in Kupfferzellen die Expression der PGE2-synthetisierenden Enzyme und verschiedener pro-inflammatorische Cytokine. Sie k{\"o}nnten somit zu einer Progression von NAFL zu NASH beitragen. Die Daten aus dieser Arbeit deuten darauf hin, dass PGE2 im Rahmen von entz{\"u}ndlichen Leberver{\"a}nderungen eine eher protektive Wirkung im Hinblick auf die Progression von NAFLD und Insulinresistenz haben k{\"o}nnte.}, language = {de} } @phdthesis{Gremske, author = {Gremske, Georg}, title = {Prozesse abbilden}, series = {Image}, journal = {Image}, number = {140}, publisher = {transcript}, address = {Bielefeld}, isbn = {978-3-8376-4500-2}, doi = {10.14361/9783839445006}, school = {Universit{\"a}t Potsdam}, pages = {448}, abstract = {Diagrammatische Bilder k{\"o}nnen Unsichtbares sichtbar machen, Abstraktes verk{\"u}rzen und neue Relationen von Text und Bild herstellen. Auch zeitliche Abl{\"a}ufe und Prozesse k{\"o}nnen durch Diagramme ins Bild gesetzt werden. Georg Gremske zeigt in seiner Studie zur Funktion der Punktlinie auf, welche geometrischen Grundformen daf{\"u}r maßgeblich sind. Nach dem diagrammatic turn der 1990er Jahre er{\"o}ffnet sich hier ein neuer Blick auf diagrammatische Darstellungen in Kunst, Wissenschaft und Technik. Der Band bietet zudem grundlegende Einsichten in die Funktionsweise von Linien und Punkten in ihrer Beziehung zu unterschiedlichen Medien.}, language = {de} } @phdthesis{Seibert, author = {Seibert, Tanja Stefanie}, title = {The T6P pathway in Solanum tuberosum}, pages = {212}, language = {en} } @phdthesis{Matic, author = {Matic, Aleksandar}, title = {Myrcene to materials}, school = {Universit{\"a}t Potsdam}, pages = {117}, language = {en} } @phdthesis{Karimi, author = {Karimi, Marzieh}, title = {Mechanical properties of vesicle membranes in asymmetric buffer conditions}, school = {Universit{\"a}t Potsdam}, pages = {96}, language = {en} } @phdthesis{Kar, author = {Kar, Manaswita}, title = {Energy band gap tuning of halide perovskite materials from first principles}, school = {Universit{\"a}t Potsdam}, abstract = {Solar cells based on hybrid perovskites materials have become significantly important among the third generation photovoltaics over the last few years. The first solid state solar cell was reported in 2012. Over the years, the power conversion efficiencies of these devices have increased at a tremendous pace and this has made the perovskite solar cell devices a serious competitor in the well-established market of thin-film and wafer technologies. Over time, a large number of articles on this topic has been published in peer-reviewed journals. The presence of lead in the most efficient hybrid perovskite materials have raised questions about the possible toxicity of these devices and the extent of their environmental impact. Therefore, a lot of research has been devoted to finding alternative perovskite materials with similar or even better opto-electronic properties. An alternative strategy to improve the efficiency of thin film solar cells is to build efficient tandem cells by combining two or more perovskite materials with specifically tailored band gaps. The first step towards the development of perovskite-only tandem solar cells is to identify complementary hybrid perovskite materials with specific band gaps that maximize the efficiency of tandem solar cells. The optimal set of optical gaps for a tandem structure made of two materials is 1.9 eV and 1.0 eV. Since the electronic properties of hybrid perovskites are known to be strongly dependent on the composition and distortion of the crystal lattice, strong focus has been made towards the structure optimisation as well as the calculation of the energy band gaps of the materials using density functional theory (DFT). In an attempt to study the structure-property relationship of these perovskite materials and to find novel perovskite materials for future applications, researchers have employed computational screening procedures to study a large range of these materials by systematic replacement of the cations and anions from the prototypical perovskite. Density functional theory in particular is used as a theoretical tool, because of it's precision to determine the properties of materials and also it's computational viability in dealing with complex systems. In this thesis, the main focus is to do a systematic screening of the perovskite materials, of the composition ABX3 again by replacing the A-site, B-site and the X-site elements to find novel materials with band gaps suitable for application in tandem solar cells. As a first step towards contributing to this vibrant field of research, a high-throughput computational screening has been performed by replacing the metal and the halogen in the conventional CH3NH3PbI3 perovskites with homovalent metals and halogens to find materials in the desired range of band gaps that has already been mentioned earlier. This is achieved by performing a geometry optimisation on all the simulated structures followed by calculating their energy band gaps at the semilocal and the hybrid levels of theory. However, it is well known that the rotation of the organic cation CH3NH3 hinders the stability of these devices by the formation of hydrogen bonds between the hydrogen atoms of the cation and the halogens. This causes the materials to degrade under normal temperature and pressure conditions. As an attempt to prevent these devices from being unstable, a next step has been taken where the CH3NH3 cation has been replaced by inorganic cations of similar ionic radius. This is followed by another thorough screening, similar to the previous step. The stability of the materials has been determined by using the empirical Goldschmidt tolerance factor. As a last part of the thesis, a small proportion of the inorganic cation is mixed with CH3NH3 in order to form mixed-halide perovskites. These structures are optimised and their band gaps are calculated using density functional theory in order to predict materials suitable for single junction as well as tandem solar cell devices. It is expected that the contribution made through this thesis will be helpful for the progress of perovskite solar cells in terms of efficiencies and will also allow the community to explore the different properties these materials for further progress and development.}, language = {en} } @phdthesis{DeCahsan, author = {De Cahsan, Binia}, title = {Introgressive hybridization in northern range margin populations of the European fire-bellied toad (Bombina bombina)}, address = {Potsdam}, school = {Universit{\"a}t Potsdam}, pages = {108}, abstract = {The European fire-bellied toad (Bombina bombina) is regarded as one of the most threatened species of amphibians in central Europe and is particularly affected by environmental perturbations. During the last decades population numbers in Germany have declined drastically due to pollution, eutrophication and habitat fragmentation. Illegal translocations resulted in an introgression from southern genotypes (probably Austrian) into three local Bombina populations (Northern Germany and Southern Sweden) belonging to the northern lineage of the species. Interestingly, these populations show high frequencies of allochthonous (non-local) alleles at multiple loci and outperform the autochthonous populations in terms of their body condition. Over a time period of ten years, I could show that the Southern lineage haplo- and genotypes are still present in the North and that frequencies of introgressed haplotypes in allochthonous populations did not increase over time. However, the introgression itself expanded towards adjacent populations while the overall haplotype diversity has decreased. In contrast, southern lineage genotypes for two candidate genes under selection, the (immunity) MHC class II gene, as well as the (temperature) stress response HSP70 kDa gene, either do not occur at all or only at low frequencies in northern populations. Furthermore, these alleles do not seem to follow the introgression pattern, as they are also present in non-introgressed populations. This thesis tested two possible outcomes of introgressive hybridization in Northern B. bombina populations: (1) local populations (autochthonous) of Bombina bombina are highly adapted to their environments so that introgression of alien genes causes outbreeding depression or (2) local populations of Bombina bombina potentially lack adaptive variation so that introgression of alien genes causes genetic rescue and promotes adaptive change. I found that this unintentional experiment, as a result of illegal translocations imitating introgression of alien genes coming from a southern population (potentially adapted to warmer climate) into a northern lineage (potentially adapted to local pathogens), has increased the genetic diversity and improved fitness in introgressed northern populations, without disrupting local adaptation in the threatened amphibian species B. bombina, favouring the genetic rescue hypothesis. These results and conclusions represent relevant information for future conservation plans, including supportive breeding programmes for fire-bellied toads in Northern Germany and Southern Sweden.}, language = {en} } @phdthesis{Mumm, author = {Mumm, Rebekka}, title = {Eat and you should grow}, school = {Universit{\"a}t Potsdam}, pages = {84}, language = {en} } @phdthesis{Riedel, author = {Riedel, Fabian}, title = {Und abends in die Scala!}, series = {Potsdamer J{\"u}dische Studien ; 4}, volume = {2019}, journal = {Potsdamer J{\"u}dische Studien ; 4}, publisher = {be.bra wissenschaft verlag}, address = {Berlin}, isbn = {978-3-95410-232-7}, school = {Universit{\"a}t Potsdam}, pages = {370}, abstract = {„… und abends in die SCALA!" Das war in den sogenannten Goldenden Zwanzigern der einschl{\"a}gige Werbeslogan f{\"u}r vergn{\"u}gungss{\"u}chtige Berliner, denen das Variet{\´e}theater erm{\"o}glichte, f{\"u}r einen Abend den beschwerlichen Alltag hinter sich zu lassen. Tats{\"a}chlich wurden die 1919 gegr{\"u}ndete SCALA in Sch{\"o}neberg und das 1928 etablierte Variet{\´e}theater PLAZA im vormaligen Ostbahnhof in Berlin-Friedrichshain zu Wahrzeichen einer sich neu bildenden Gesellschaft. Beide hatte eine Gruppe j{\"u}discher Kaufleute aus Berlin und {\"U}bersee gegr{\"u}ndet, die zun{\"a}chst durch den Umbau des ehemaligen Berliner Eispalasts das SCALA-Theater zur ersten Adresse einer neuen Art der Variet{\´e}-Revue entwickelten. Zu den Gr{\"u}ndungsgesellschaftern geh{\"o}rten der Verleger und Kinopionier Karl Wolffsohn sowie acht weitere Gesch{\"a}ftspartner, darunter der Bankkaufmann Jules Marx, der Flugzeugindustrielle Anton Fokker, der Modeunternehmer Ernst Strelitz und der US-amerikanische Filmunternehmer Ben Blumenthal. Die SCALA feierte in den 1920er-Jahren große Erfolge. Sie wurde schon bald nach ihrer Gr{\"u}ndung zu einem weit {\"u}ber die Grenzen Deutschlands hinaus bekannten Variet{\´e}theater, in dem Showgr{\"o}ßen wie der Jongleur Enrico Rastelli, die ber{\"u}hmten Clowns Grock und Charlie Rivel oder die Comedian Harmonists auftraten. Seinen j{\"u}dischen Gesellschaftern gl{\"u}ckte mit der SCALA sowohl ein k{\"u}nstlerischer als auch, und dies vielleicht in h{\"o}herem Maße, ein wirtschaftlicher Coup. In den sp{\"a}teren Jahren der Weimarer Republik kam es infolge der Weltwirtschaftskrise seit dem Herbst 1929 und der immer instabileren politischen Verh{\"a}ltnisse zu einer anhaltenden wirtschaftlichen Degression. Noch kurz davor, im Jahr 1928, hatten die erfolgsverw{\"o}hnten und zukunftsorientierten Gesellschafter der SCALA die Expansion ihres Unternehmens gewagt und als P{\"a}chter der Reichsbahn im einstigen Ostbahnhof Berlins unter Aufbringung erheblicher finanzieller Mittel ein 3..000 Pl{\"a}tze umfassendes, innovatives Volksvariet{\´e} gegr{\"u}ndet. Auch die PLAZA war in ihren ersten Jahren - trotz der allgemeinen Wirtschaftskrise - ein Erfolgsmodell, das erstmals die Arbeiterschaft als Zielgruppe ins Visier nahm und zahlreich ins Variet{\´e}theater lockte. Ab 1930 betrieb der Konzern der SCALA und PLAZA weitere Theater in Hamburg, Leipzig, Mannheim, Dortmund und Rotterdam. Den H{\"o}hepunkt des Unternehmenserfolgs stellt der Sommer 1931 mit der Gr{\"u}ndung einer internationalen Buchungsgemeinschaft f{\"u}r weltbekannte K{\"u}nstler in Partnerschaft mit der UFA und f{\"u}hrenden Variet{\´e}s in Paris und London dar. Zur Finanzierung des laufenden Betriebs nahm der Konzern der Variet{\´e}theater SCALA und PLAZA hypothekarisch und durch pers{\"o}nliche selbstschuldnerische B{\"u}rgschaften der j{\"u}dischen Gesellschafter gesichertes Fremdkapital der Bayerischen Vereinsbank M{\"u}nchen, der Vereinsbank N{\"u}rnberg, der Deutschen Unionbank und der Dresdner Bank auf. Das wurde notwendig aufgrund hoher Entnahmen der Gesellschafter und auch wegen des enorm kostspieligen Umbaus des Berliner Ostbahnhofs, der gleichzeitig mit einer Expansion in zahlreiche weitere Theater erfolgte. Ab Ende des Jahres 1931 traf der seit der Weltwirtschaftskrise anhaltende Niedergang der Variet{\´e}branche den im Aufbau befindlichen Konzern hart und f{\"u}hrte zu schwer {\"u}berwindbaren Zahlungsschwierigkeiten. Gr{\"u}nde daf{\"u}r waren neben dem Fernbleiben des sich jegliches Kulturvergn{\"u}gen sparenden Publikums auch ge{\"a}nderte Anspr{\"u}che. Vor allem der Aufstieg des Kinos, das sich mithilfe des Tonfilms zu einer neuen Kulturgattung entwickelte, f{\"u}hrte zu immer leereren R{\"a}ngen der klassischen Variet{\´e}b{\"u}hnen. Hinzu kamen harte R{\"u}ckschl{\"a}ge bei einigen sich als Fehlspekulation erweisenden Engagements in der Provinz. In der Folge musste weiteres, hochverzinsliches Fremdkapital aufgenommen werden, was die Handlungsspielr{\"a}ume des Konzerns immer weiter einschr{\"a}nkte. Die Gl{\"a}ubigerbanken wurden zusehends nerv{\"o}ser und richteten im Februar 1932 einen Kontrollausschuss ein, der die Gesch{\"a}ftsf{\"u}hrung {\"a}hnlich wie der Aufsichtsrat einer Aktiengesellschaft kontrollierte. Daf{\"u}r erkl{\"a}rten sich die Banken, allen voran die Dresdner Bank und die Deutsche Unionbank, bereit, bis auf weiteres mit ihren Forderungen stillzuhalten. Mit der Machtergreifung der Nationalsozialisten Ende Januar 1933 gerieten die j{\"u}dischen Gesellschafter des prominenten Berliner Großunternehmens mit mehreren Hundert Angestellten auch politisch unter Druck. Schon im April 1933 wurde die gesamte j{\"u}dische Gesch{\"a}ftsf{\"u}hrung gleichgeschaltet und alle j{\"u}dischen Mitarbeiter wurden entlassen. Dabei wurde die SCALA boykottiert und mehrfach von randalierenden nationalsozialistischen Unruhestiftern heimgesucht. Der Direktor der SCALA, Jules Marx, musste Berlin fluchtartig nach Paris verlassen. Anstatt der jahrelang im Unternehmen befindlichen j{\"u}dischen Gesch{\"a}ftsf{\"u}hrer installierten die Gl{\"a}ubigerbanken ihnen nahestehende, fachfremde Autodidakten an den Machtpositionen des Konzerns. Die Folge waren noch h{\"o}here Verluste bei der SCALA und wegbrechende Einnahmen bei der PLAZA. Zudem setzte ab 1933 das NS-Regime, insbesondere das Propagandaministerium und die Gewerkschaften, die Hauptkreditgeber Dresdner Bank und Deutsche Unionbank zunehmend unter Druck, das in j{\"u}discher Hand befindliche Unternehmen zu „arisieren". Schon im Jahr 1934 wurde die SCALA wegen R{\"u}ckst{\"a}nden bei der Hauptsteuerkasse und drohender Klagen unter Zwangsverwaltung gestellt. Kurze Zeit sp{\"a}ter kam es zur K{\"u}ndigung eines wichtigen Vertrages zwischen der Betriebsgesellschaft der SCALA und ihrer Immobiliengesellschaft. Eine neue Betriebsgesellschaft, finanziert durch die Deutsche Unionbank und gef{\"u}hrt von den durch die Banken installierten NS-Mitgliedern, schloss kurzerhand einen neuen Pachtvertrag mit der Immobiliengesellschaft ab und eliminierte damit die Einflussnahme der j{\"u}dischen Gesellschafter auf ihr Unternehmen. Bereits im Jahr 1935 wurde das SCALA-Grundst{\"u}ck zwangsversteigert und ebenfalls von der neuen „judenfreien" Betriebsgesellschaft mit Mitteln der Deutschen Unionbank erworben. Die j{\"u}dischen Gesellschafter gingen leer aus. Dagegen erwarben sich die neuen nationalsozialistischen Inhaber der SCALA einen guten Ruf und bauten sie wieder auf. Durch regelm{\"a}ßige Besuche oberster Parteikader der NSDAP, inklusive Adolf Hitler und Joseph Goebbels, gelangte das Variet{\´e}theater in den 1930er-Jahren zu erneutem, aber zweifelhaftem Ruhm. Im Jahr 1944 wurde es vollst{\"a}ndig ausgebombt. Die PLAZA dagegen wurde durch Kredite der Dresdner Bank finanziert, die sich schon 1929 f{\"u}r ihr Engagement die Anteile der Betriebsgesellschaft der PLAZA pfandweise {\"u}bertragen ließ. Als im Jahr 1934 der Konzern am Rande des Zusammenbruchs stand und auch keine Aussicht auf eine kurz- bis mittelfristige Besserung bestand, zog sich die Dresdner Bank auf ihre Sicherheit zur{\"u}ck. Hintergrund war ein Pakt mit dem Reichspropagandaministerium, das die „Arisierung" des Konzerns forderte. Im August 1934 versteigerte die Dresdner Bank die ihr pfandweise {\"u}berlassenen Anteile der Betriebsgesellschaft - jedoch ohne Erfolg: Die Bank musste die Anteile selbst {\"u}bernehmen und wurde in der Folge Eigent{\"u}mer eines langfristigen Pachtvertrages mit der Deutschen Reichsbahn Gesellschaft zum Betrieb des Theaters. Da jegliche Versuche, das Theater anderen interessierten Unternehmen oder auch der Organisation „Kraft durch Freude" und dem Propagandaministerium zu {\"u}berlassen, scheiterten, sah sich die Bank im Sommer 1935 gezwungen, keine weiteren Mittel zur Aufrechterhaltung der am Boden befindlichen Betriebsgesellschaft des Theaters zur Verf{\"u}gung zu stellen. {\"U}ber die Betriebsgesellschaft wurde Konkursantrag gestellt und die Dresdner Bank verlor ihr knapp 2 Millionen RM hohes Engagement. Die NS-Gemeinschaft „Kraft durch Freude" {\"u}bernahm 1938 schließlich doch noch das Theater, bis es 1944 kriegsbedingt schließen musste. Im Jahr 1938 kam Karl Wolffsohn, Mitgr{\"u}nder und Mitgesellschafter des Konzerns, in monatelange Schutzhaft der Gestapo. Da kurz nach der Haftentlassung eine weitere Inhaftierung wegen Steuervergehen drohte, musste er im Fr{\"u}hjahr 1939 {\"u}ber Nacht aus Deutschland fliehen und emigrierte nach Pal{\"a}stina. Im Nachkriegsdeutschland k{\"a}mpfte Wolffsohn um „Wiedergutmachung" f{\"u}r das ihm zugef{\"u}gte Unrecht. Dabei wurde ihm schnell klar, wie enorm langwierig und kompliziert die Beweisf{\"u}hrung f{\"u}r die verwickelten Vorg{\"a}nge der Vorkriegszeit werden w{\"u}rde. Zwei Verfahren strengte Wolffsohn mitsamt den ehemaligen Gesellschaftern oder deren Erben gegen die untreuen ehemaligen Gesch{\"a}ftsf{\"u}hrer der SCALA, die neue Betriebsgesellschaft der SCALA und die Deutsche Unionbank an, die er beide nach Urteilen des Landgerichts Berlin, des Kammergerichts Berlin und des Obersten R{\"u}ckerstattungsgerichts verlor. Außerdem nahmen Wolffsohn und seine Mitgesellschafter die Dresdner Bank wegen der PLAZA in Anspruch. Die Bank reagierte, indem sie ihrerseits Wolffsohn aufgrund seiner selbstschuldnerischen B{\"u}rgschaft aus dem Jahr 1929 verklagte. Im Sommer 1956 gewann die Dresdner Bank den jahrelangen B{\"u}rgschaftsprozess mit einem Urteil des Bundesgerichtshofs: Karl Wolffsohn wurde dazu verurteilt, einen Teilbetrag seiner damaligen B{\"u}rgschaft von 6.100,- DM zu zahlen. Nur ein Jahr sp{\"a}ter starb er infolge eines Herzinfarkts. Die nervenaufreibenden Verfahren hatten ihn zunehmend an der Gerichtsbarkeit der noch jungen Bundesrepublik zweifeln lassen. Sein Sohn Max Wolffsohn beendete schließlich den Prozess mit der Dresdner Bank im Wege eines Vergleichs, da er bef{\"u}rchten musste, weiterhin aus der B{\"u}rgschaft seines Vaters in Anspruch genommen zu werden. Dabei mussten die ehemaligen Gesellschafter der PLAZA im Dezember 1961 sogar eine Ehrenerkl{\"a}rung abgeben, in der sie die Inanspruchnahme der Dresdner Bank ausdr{\"u}cklich bedauerten. Heute erinnert eine Gedenktafel am Franz-Mehring-Platz 1 in Berlin-Friedrichshain an den Konzern der Variet{\´e}theater SCALA und PLAZA und dessen Mitgr{\"u}nder Karl Wolffsohn und Jules Marx.}, language = {de} } @phdthesis{Colangeli, author = {Colangeli, Pierluigi}, title = {From pond metacommunities to life in a droplet}, school = {Universit{\"a}t Potsdam}, pages = {126}, language = {en} } @phdthesis{Huettel, author = {H{\"u}ttel, Alexandra}, title = {The role of human values in sustainable consumption}, school = {Universit{\"a}t Potsdam}, language = {en} } @phdthesis{Frede, author = {Frede, Katja}, title = {Light-modulated biosynthesis of carotenoids in Brassica rapa ssp. chinensis and the activation of Nrf2 by lutein in human retinal pigment epithelial cells}, pages = {98}, language = {en} } @phdthesis{Querengaesser, author = {Quereng{\"a}sser, Alexander}, title = {Das kurs{\"a}chsische Milit{\"a}r im Großen Nordischen Krieg 1700-1717}, series = {Krieg in der Geschichte ; 107}, journal = {Krieg in der Geschichte ; 107}, publisher = {Verlag Ferdinand Sch{\"o}ningh}, address = {Paderborn}, isbn = {978-3-506-78871-9}, school = {Universit{\"a}t Potsdam}, pages = {628}, abstract = {Trotz der herausragenden Bedeutung, die dem Großen Nordischen Krieg in der s{\"a}chsischen Geschichte zukommt, ist dieses Ereignis von der Forschung kaum erforscht worden. Der Autor analysiert den Aufbau der kurs{\"a}chsischen Ar-mee und zeichnet den Verlauf ihrer Feldz{\"u}ge und Schlachten anhand erstmals ausgewerteter Quellen detailliert nach. Der Große Nordische Krieg stellt einen der wichtigsten milit{\"a}rischen Konflikte in der neuzeitlichen Geschichte Kur-sachsens dar. August der Starke, Kurf{\"u}rst von Sachsen und K{\"o}nig von Polen, versuchte durch schnelle Erfolge sei-ner Waffen die Union zwischen seinen beiden L{\"a}ndern zu st{\"a}rken. Stattdessen aber reihte sich Niederlage an Nie-derlage, die heute vor allem der R{\"u}ckst{\"a}ndigkeit der s{\"a}chsischen Armee zugeschrieben werden. Der Autor unter-sucht ausf{\"u}hrlich die Struktur der s{\"a}chsischen Truppen, zeichnet den Verlauf der einzelnen Feldz{\"u}ge und Schlach-ten anhand neu erschlossenen Quellen detailliert nach und revidiert viele alte Vorurteile.}, language = {de} } @phdthesis{Portner, author = {Portner, David}, title = {Strafbarkeit des Kick-back-Vorgangs in der {\"o}ffentlichen Auftragsvergabe}, series = {Schriftenreihe zum deutschen, europ{\"a}ischen und internationalen Wirtschaftsstrafrecht ; 37}, journal = {Schriftenreihe zum deutschen, europ{\"a}ischen und internationalen Wirtschaftsstrafrecht ; 37}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-6023-7}, pages = {497}, abstract = {Die staatliche Beschaffungst{\"a}tigkeit ist korruptionsanf{\"a}llig. Eine Sonderform der Korruption ist das „Kick-back". Dabei handelt es sich um eine in den Auftragspreis inkludierte Zuwendung eines Unternehmenshandelnden an einen Bediensteten des vergebenden {\"o}ffentlichen Auftraggebers f{\"u}r eine Bevorzugung im Vergabeverfahren. Kick-backs sch{\"a}digen sowohl das staatliche Verm{\"o}gen als auch den Leistungswettbewerb. Die {\"o}ffentliche Auftragsvergabe muss daher mit einer wirksamen Pr{\"a}vention durch das Vergaberecht und einer umfassenden Sanktionsandrohung durch das Strafrecht vor Kick-backs gesch{\"u}tzt werden. Der Autor untersucht, inwieweit das Vergabe- und das Strafrecht dieser Aufgabe gerecht werden. Er analysiert das Vergaberecht nach Pr{\"a}ventions- und Missbrauchspotenzialen sowie die Strafbarkeitsrisiken f{\"u}r an der Vergabe mitwirkende Bedienstete des Auftraggebers. Darauf aufbauend entwickelt er Vorschl{\"a}ge f{\"u}r eine intensivere Bek{\"a}mpfung von Kick-backs, unter anderem einen Sonderstraftatbestand.}, language = {de} } @phdthesis{Haase, author = {Haase, Sarah}, title = {Zivilgesellschaftliches Engagement im Wandel}, series = {Sanssouci - Forschungen zur Romanistik}, journal = {Sanssouci - Forschungen zur Romanistik}, number = {17}, publisher = {Frank \& Timme GmbH}, address = {Berlin}, isbn = {978-3-7329-0459-4}, school = {Universit{\"a}t Potsdam}, pages = {478}, language = {de} } @phdthesis{Rohn, author = {Rohn, Isabelle}, title = {Food-relevant selenium species}, school = {Universit{\"a}t Potsdam}, pages = {132,VIII}, language = {en} } @phdthesis{SchrothderZweite, author = {Schroth der Zweite, Amelie}, title = {Der Vertraulichkeitsschutz von Mediationsinhalten}, series = {Schriften zum Prozessrecht ; 265}, volume = {2020}, journal = {Schriften zum Prozessrecht ; 265}, publisher = {Duncker \& Humblot}, address = {Berlin}, isbn = {978-3-428-18003-5}, school = {Universit{\"a}t Potsdam}, pages = {214}, abstract = {Die Arbeit untersucht den materiell- und prozessrechtlichen Istzustand des Vertraulichkeitsschutzes von Informationen, von denen an einer Mediation Beteiligte aufgrund der Durchf{\"u}hrung des Mediationsverfahrens Kenntnis erlangt haben und er{\"o}rtert sodann den Sollzustand dieses Schutzes. Die Ergebnisse der Er{\"o}rterung werden in einem Formulierungsvorschlag zur Umgestaltung von \S 4 MediationsG sowie in einer Mustervereinbarung f{\"u}r die Mediationsbeteiligten als privatautonome Schutzerg{\"a}nzung umgesetzt.}, language = {de} } @phdthesis{Mitrova, author = {Mitrova, Biljana}, title = {Bioelectrochemical investigation of E. coli TMAO reductase and R. capsulatus formate dehydrogenase}, school = {Universit{\"a}t Potsdam}, pages = {105}, language = {en} } @phdthesis{Schmidt, author = {Schmidt, Max Oliver}, title = {Umk{\"a}mpftes Asyl}, school = {Universit{\"a}t Potsdam}, pages = {412}, language = {de} } @phdthesis{Feil, author = {Feil, Hauke}, title = {God, bad, or ugly: Does it really matter?}, address = {Potsdam}, school = {Universit{\"a}t Potsdam}, pages = {XII, 224}, abstract = {Each year, donor countries spend billions of Euros on development cooperation. Not surprisingly, a large strand of research has emerged which examines the impact of development cooperation. A sub-discipline within this strand of the literature deals with the question of whether the impact or effectiveness of development cooperation depends on the quality of the recipient country's policy and institutional environment. Over hundreds of studies have assessed this question at the macro level. In so doing, most of these studies test whether a potential effect of aid on the growth of a recipient country's gross domestic product (GDP) is conditional on the country's policy and institutional environment. However, even after decades of research and hundreds of studies, no conclusive result has been found. One of the main reasons for the inconclusive state of the literature is that most macro-level studies have to deal with a high risk of endogeneity, treat aid as nothing but a pure income transfer, and rely on low-quality GDP data. To solve these three methodical issues, some authors have started to change the analytical focus from the macro to the micro level. Thus, these authors assess the determinants for the performance of individual development projects instead of the determinants for an effect of aid on GDP. Yet, even though the number of studies focusing on the micro level has increased steadily over the last few years, the state of the literature on the determinants for the performance of development projects still contains multiple highly relevant research gaps. The present thesis seeks to address three of these research gaps. The first research gap addressed by this thesis is related to the specific type of development cooperation. So far, nearly all existing studies focus on projects by Multilateral Development Banks. Research on the determinants for the performance of bilateral development projects is still rare. Thus, even though donors pledge to implement effective development projects, there are hardly any micro-level studies on bilateral projects. So far, only three studies use a sample which includes bilateral projects. Yet, none of the three studies assess the determinants for the performance of bilateral technical development projects. The first paper in the present thesis (GIZ paper) seeks to address this research gap by assessing the determinants for the performance of projects by the Deutsche Gesellschaft f{\"u}r Internationale Zusammenarbeit (GIZ), a bilateral state-owned aid agency active in the area of technical cooperation. The results of the paper indicate that some but not all of the existing theoretical arguments can be extended to bilateral technical projects as well.. For example, the level of market interventions in the recipient county only affects the performance of financial development projects, while the recipient country's government capacity affects both technical and financial development projects. The paper also indicates that effects of determinants may vary among project sectors. The paper also highlights a dilemma of technical development cooperation. The countries with low government capacity are usually the ones most in need of technical cooperation projects. But, at the same time, they are also the countries in which these projects have the poorest performance The second research gap addressed by this thesis is related to one specific factor in the policy and institutional environment of recipient countries, namely corruption. This determinant is often cited as essential for project performance but has gained surprisingly little coverage in empirical studies. The few existing studies on the effect of corruption on project performance are inconclusive. Some find a statistically significant correlation, while others do not. Furthermore, so far, all existing studies use corruption perception indices as a measurement for corruption, despite the fact that these indices have well-known deficits when it comes to this research topic. One of these deficits is that such indices do not distinguish between different forms of corruption, even though it is likely that the effect of corruption will vary depending on the type of development project and form of corruption. The second paper in this thesis (Corruption paper) seeks to address this inconclusive state of the research while focusing on one specific form of corruption, namely bribery between private firms and public officials. The paper finds a small but statistically significant correlation between the corruption level and the performance of World Bank projects. The systematic effect of corruption on project performance confirms the need to consider the risk of corruption in the design and during the implementation of projects. Nonetheless, the relatively small effect of corruption and the low pseudo R-squareds advise not to overestimate the relevance of corruption for project performance. At least for the project level, the paper finds no indication that corruption is a primary obstacle to aid effectiveness. The third research gap addressed by this thesis is related to one specific sample, namely recipient countries of the International Development Association (IDA). The question of whether the policy and institutional environment affects project performance is of particular relevance for these countries, given that the World Bank's ratings on a country's policy and institutional environment decide how much IDA resources it receives. One core justification of such an allocation system is that it helps to steer more resources to places where they are most effective. However, so far, there is no conclusive empirical evidence for this statement. The only study specifically focusing on this topic, a study by the Independent Evaluation Group of the World Bank from 2010, has essential methodological limitations. The third paper of this thesis (CPR paper) seeks to address this research gap by testing whether a more refined analysis confirms the assumption of previous studies that the policy and institutional environment of IDA-recipient countries, measured by the Country Policy and Institutional Assessment ratings, has an effect on the performance of World Bank projects. Overall, neither the main regression models nor any of the robustness tests indicate a substantial correlation between the policy and institutional environment and project performance. Only for Investments Loans is the coefficient large enough to assume some effect. The overall results not only contradict the results of previous studies, but also raise strong doubts around one of the core justifications for the allocation system of the IDA. All three papers rely on a statistical large-N analysis of the performance ratings of individual development projects. These ratings are usually assigned based on the final evaluation of a project and indicate the merit or worth of an activity. The merit or worth of an activity itself is measured by criteria like relevance, effectiveness, and efficiency. In the case of the two papers on World Bank projects, the needed data stem from different databases of the World Bank. The relevant data for the GIZ paper are gathered from internal evaluation reports of the GIZ. Logistic regressions are applied as the main analytical tool. Overall, the three papers show that the policy and institutional environment of recipient countries matters for project performance, but only to a small degree and under certain circumstances. This result highlights that many researchers and practitioners tend to overestimate the role that the policy and institutional environment of recipient countries plays in project performance. Furthermore, the thesis shows that authors of future studies should consider possible interactions between project- and country-level determinants whenever possible, both in their theoretical arguments and statistical models. Otherwise, the debate on the determinants for project performance is at risk of degenerating into a statistics tournament without any connection to reality.}, language = {en} }