@article{SchmiedchenLongardtLouietal.2016,
  author    = {Schmiedchen, Bettina and Longardt, Ann Carolin and Loui, Andrea and Buehrer, Christoph and Raila, Jens and Schweigert, Florian J.},
  title     = {Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants},
  series = {European journal of pediatrics : official organ of the Belgian Pediatric Association},
  volume    = {175},
  journal   = {European journal of pediatrics : official organ of the Belgian Pediatric Association},
  publisher = {Springer},
  address   = {New York},
  issn      = {0340-6199},
  doi       = {10.1007/s00431-015-2647-9},
  pages     = {365 -- 372},
  year      = {2016},
  abstract  = {Despite high-dose vitamin A supplementation of very low birth weight infants (VLBW, <1500 g), their vitamin A status does not improve substantially. Unknown is the impact of urinary retinol excretion on the serum retinol concentration in these infants. Therefore, the effect of high-dose vitamin A supplementation on the urinary vitamin A excretion in VLBW infants was investigated. Sixty-three VLBW infants were treated with vitamin A (5000 IU intramuscular, 3 times/week for 4 weeks); 38 untreated infants were classified as control group. On days 3 and 28 of life, retinol, retinol-binding protein 4 (RBP4), glomerular filtration rate, proteinuria, and Tamm-Horsfall protein were quantified in urine. On day 3 of life, substantial retinol and RBP4 losses were found in both groups, which significantly decreased until day 28. Notwithstanding, the retinol excretion was higher (P<0.01) under vitamin A supplementation as compared to infants of the control group. On day 28 of life, the urinary retinol concentrations were predictive for serum retinol concentrations in the vitamin A treated (P<0.01), but not in the control group (P=0.570). Conclusion: High urinary retinol excretion may limit the vitamin A supplementation efficacy in VLBW infants. Advanced age and thus postnatal kidney maturation seems to be an important contributor in the prevention of urinary retinol losses.},
  language  = {en}
}