@article{LiuLaemkeLinetal.2018,
  author    = {Liu, Hsiang-chin and L{\"a}mke, J{\"o}rn and Lin, Siou-ying and Hung, Meng-Ju and Liu, Kuan-Ming and Charng, Yee-yung and B{\"a}urle, Isabel},
  title     = {Distinct heat shock factors and chromatin modifications mediate the organ-autonomous transcriptional memory of heat stress},
  series = {The plant journal},
  volume    = {95},
  journal   = {The plant journal},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0960-7412},
  doi       = {10.1111/tpj.13958},
  pages     = {401 -- 413},
  year      = {2018},
  abstract  = {Plants can be primed by a stress cue to mount a faster or stronger activation of defense mechanisms upon subsequent stress. A crucial component of such stress priming is the modified reactivation of genes upon recurring stress; however, the underlying mechanisms of this are poorly understood. Here, we report that dozens of Arabidopsis thaliana genes display transcriptional memory, i.e. stronger upregulation after a recurring heat stress, that lasts for at least 3 days. We define a set of transcription factors involved in this memory response and show that the transcriptional memory results in enhanced transcriptional activation within minutes of the onset of a heat stress cue. Further, we show that the transcriptional memory is active in all tissues. It may last for up to a week, and is associated during this time with histone H3 lysine 4 hypermethylation. This transcriptional memory is cis-encoded, as we identify a promoter fragment that confers memory onto a heterologous gene. In summary, heat-induced transcriptional memory is a widespread and sustained response, and our study provides a framework for future mechanistic studies of somatic stress memory in higher plants.},
  language  = {en}
}
@misc{Baeurle2017,
  author    = {B{\"a}urle, Isabel},
  title     = {Can't remember to forget you},
  series = {Seminars in cell \& developmental biology},
  volume    = {83},
  journal   = {Seminars in cell \& developmental biology},
  publisher = {Elsevier},
  address   = {London},
  issn      = {1084-9521},
  doi       = {10.1016/j.semcdb.2017.09.032},
  pages     = {133 -- 139},
  year      = {2017},
  abstract  = {In nature plants are exposed to frequent changes in their abiotic and biotic environment. While some environmental cues are used to gauge the environment and align growth and development, others are beyond the regularly encountered spectrum of a species and trigger stress responses. Such stressful conditions provide a potential threat to survival and integrity. Plants adapt to extreme environmental conditions through physiological adaptations that are usually transient and are maintained until stressful environments subside. It is increasingly appreciated that in some cases environmental cues activate a stress memory that persists for some time after the extreme condition has subsided. Recent research has shown that this stress-induced environmental memory is mediated by epigenetic and chromatin-based mechanisms and both histone methylation and nucleosome occupancy are associated with it.},
  language  = {en}
}
@article{LaemkeBrzezinkaAltmannetal.2016,
  author    = {L{\"a}mke, J{\"o}rn and Brzezinka, Krzysztof and Altmann, Simone and B{\"a}urle, Isabel},
  title     = {A hit-and-run heat shock factor governs sustained histone methylation and transcriptional stress memory},
  series = {The EMBO journal},
  volume    = {35},
  journal   = {The EMBO journal},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0261-4189},
  doi       = {10.15252/embj.201592593},
  pages     = {162 -- 175},
  year      = {2016},
  abstract  = {In nature, plants often encounter chronic or recurring stressful conditions. Recent results indicate that plants can remember a past exposure to stress to be better prepared for a future stress incident. However, the molecular basis of this is poorly understood. Here, we report the involvement of chromatin modifications in the maintenance of acquired thermotolerance (heat stress [HS] memory). HS memory is associated with the accumulation of histone H3 lysine 4 di- and trimethylation at memory-related loci. This accumulation outlasts their transcriptional activity and marks them as recently transcriptionally active. High accumulation of H3K4 methylation is associated with hyper-induction of gene expression upon a recurring HS. This transcriptional memory and the sustained accumulation of H3K4 methylation depend on HSFA2, a transcription factor that is required for HS memory, but not initial heat responses. Interestingly, HSFA2 associates with memory-related loci transiently during the early stages following HS. In summary, we show that transcriptional memory after HS is associated with sustained H3K4 hyper-methylation and depends on a hit-and-run transcription factor, thus providing a molecular framework for HS memory.},
  language  = {en}
}