@article{HeidlerBiduFriedrichetal.2015,
  author    = {Heidler, Maria-Dorothea and Bidu, Laura and Friedrich, Nele and V{\"o}ller, Heinz},
  title     = {Oral feeding of long-term ventilated patients with a tracheotomy tube. Underestimated danger of dysphagia},
  series = {Medizinische Klinik, Intensivmedizin und Notfallmedizin},
  volume    = {110},
  journal   = {Medizinische Klinik, Intensivmedizin und Notfallmedizin},
  number    = {1},
  publisher = {Springer},
  address   = {New York},
  issn      = {2193-6218},
  doi       = {10.1007/s00063-014-0397-5},
  pages     = {55 -- 60},
  year      = {2015},
  abstract  = {In long-term mechanically ventilated patients, dysphagia is a common and potentially life-threatening complication, which can lead to aspiration and pneumonia. Nevertheless, many intensive care unit (ICU) patients are fed by mouth without evaluation of their deglutition capability. The goal of this work was to evaluate the prevalence of aspiration due to swallowing disorders in long-term ventilated patients who were fed orally in the ICU while having a blocked tracheotomy tube. In all, 43 patients participated-each underwent a fiberoptic investigation of deglutition on the day of admission to the rehabilitation clinic. A total of 65 \% of the patients aspirated, 71 \% of these silently. There were no associations between aspiration and any of the following: gender, indication for mechanical ventilation (underlying disease) or the duration of intubation and ventilation by tracheotomy tube. However, the association between aspiration and age was statistically significant (p = 0.041). Aspirating patients were older (arithmetic mean = 70 years, median = 74 years) than patients who did not aspirate (arithmetic mean = 66 years, median = 67 years). Intubation and add-on tracheotomies can lead to potentially life-threatening swallowing disorders that cause aspiration, independent of the underlying disease. Before feeding long-term mechanically ventilated patients by mouth, their ability to swallow needs to be investigated using fiberoptic endoscopic evaluation of swallowing (FEES) or a saliva dye test, if a cuff deflation and the use of a speaking valve are possible during spontaneous respiration.},
  language  = {de}
}
@article{HeidlerBiduVoelleretal.2017,
  author    = {Heidler, Maria-Dorothea and Bidu, Laura and V{\"o}ller, Heinz and Salzwedel, Annett},
  title     = {Pr{\"a}diktoren des kognitiven Outcomes beatmeter Fr{\"u}hrehabilitationspatienten},
  series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
  volume    = {88},
  journal   = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
  publisher = {Springer},
  address   = {New York},
  issn      = {0028-2804},
  doi       = {10.1007/s00115-017-0311-5},
  pages     = {905 -- 910},
  year      = {2017},
  abstract  = {Hintergrund Patienten, die nach gescheitertem Weaning von der Intensivstation in die Fr{\"u}hrehabilitation (FR) verlegt werden, weisen neben motorischen Einschr{\"a}nkungen oft auch Defizite in ihrer kognitiven Leistungsf{\"a}higkeit auf. Welche patientenseitigen Faktoren das kognitive Outcome am Ende der FR beeinflussen, ist noch unzureichend untersucht. Zielstellung Ermittlung von Pr{\"a}diktoren auf das kognitive Leistungsverm{\"o}gen initial beatmeter FR-Patienten. Methode Zwischen 01/2014 und 12/2015 wurden 301 Patienten (68,3 ± 11,4 Jahre, 67 \% m{\"a}nnlich) einer neurologischen Phase-B-Weaningstation konsekutiv in eine prospektive Beobachtungsstudie eingeschlossen. Zur Ermittlung m{\"o}glicher Einflussfaktoren auf das kognitive Outcome (operationalisiert mittels Neuromentalindex [NMI]) wurden soziodemografische Daten, kritische Erkrankung, Komorbidit{\"a}ten, Parameter zu Weaning und Dekan{\"u}lierung sowie diverse Scores zur Ermittlung funktionaler Parameter erhoben und mittels ANCOVA multivariat ausgewertet. Ergebnisse Insgesamt 248 Patienten (82 \%) konnten erfolgreich geweant werden, 155 (52 \%) dekan{\"u}liert, 75 Patienten (25 \%) verstarben, davon 39 (13 \%) unter Palliativtherapie. F{\"u}r die {\"u}berlebenden Patienten (n = 226) konnten im finalen geschlechts- und altersadjustierten statistischen Modell unabh{\"a}ngige Pr{\"a}diktoren des NMI bei Entlassung aus der FR ermittelt werden: Wachheit und erfolgreiche Dekan{\"u}lierung waren positiv mit dem NMI assoziiert, w{\"a}hrend als kritische Erkrankungen hypoxische Hirnsch{\"a}digungen, Hirninfarkte und Sch{\"a}del-Hirn-Traumata einen negativen Einfluss auf die kognitive Leistungsf{\"a}higkeit hatten. Das berechnete Modell begr{\"u}ndet 57 \% der Varianz des NMI (R2 = 0,568) und weist damit eine hohe Erkl{\"a}rungsqualit{\"a}t auf. Schlussfolgerung Aufgrund des erh{\"o}hten Risikos f{\"u}r eine verminderte kognitive Leistungsf{\"a}higkeit zum Ende der FR sollten vor allem Patienten nach Hypoxie, Hirninfarkt und Sch{\"a}del-Hirn-Trauma intensiv neuropsychologisch betreut werden. Da weiterhin eine erfolgreiche Dekan{\"u}lierung mit verbesserten kognitiven Leistungen assoziiert ist, sollte - vor allem bei wachen Patienten - zudem ein z{\"u}giges Trachealkan{\"u}lenmanagement im therapeutischen Fokus stehen.},
  language  = {de}
}
@article{SeitzSchumacherBakeretal.2019,
  author    = {Seitz, Aaron P. and Schumacher, Fabian and Baker, Jennifer and Soddemann, Matthias and Wilker, Barbara and Caldwell, Charles C. and Gobble, Ryan M. and Kamler, Markus and Becker, Katrin Anne and Beck, Sascha and Kleuser, Burkhard and Edwards, Michael J. and Gulbins, Erich},
  title     = {Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia},
  series = {Journal of molecular medicine},
  volume    = {97},
  journal   = {Journal of molecular medicine},
  number    = {8},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0946-2716},
  doi       = {10.1007/s00109-019-01800-1},
  pages     = {1195 -- 1211},
  year      = {2019},
  abstract  = {Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad antibacterial effects of sphingosine to prevent VAP by developing a novel method of coating surfaces of endotracheal tubes with sphingosine and sphingosine analogs. Sphingosine and phytosphingosine coatings of endotracheal tubes prevent adherence and mediate killing of Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus, even in biofilms. Most importantly, sphingosine-coating of endotracheal tubes also prevented P. aeruginosa and S. aureus pneumonia in vivo. Coating of the tubes with sphingosine was stable, without obvious side effects on tracheal epithelial cells and did not induce inflammation. In summary, we describe a novel method to coat plastic surfaces and provide evidence for the application of sphingosine and phytosphingosine as novel antimicrobial coatings to prevent bacterial adherence and induce killing of pathogens on the surface of endotracheal tubes with potential to prevent biofilm formation and VAP.Key messagesNovel dip-coating method to coat plastic surfaces with lipids.Sphingosine and phytosphingosine as novel antimicrobial coatings on plastic surface.Sphingosine coatings of endotracheal tubes prevent bacterial adherence and biofilms.Sphingosine coatings of endotracheal tubes induce killing of pathogens.Sphingosine coatings of endotracheal tubes ventilator-associated pneumonia.},
  language  = {en}
}