@article{RibeiroAraujoFernieetal.2012, author = {Ribeiro, Dimas M. and Araujo, Wagner L. and Fernie, Alisdair R. and Schippers, Jos H. M. and M{\"u}ller-R{\"o}ber, Bernd}, title = {Translatome and metabolome effects triggered by gibberellins during rosette growth in Arabidopsis}, series = {Journal of experimental botany}, volume = {63}, journal = {Journal of experimental botany}, number = {7}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0022-0957}, doi = {10.1093/jxb/err463}, pages = {2769 -- 2786}, year = {2012}, abstract = {Although gibberellins (GAs) are well known for their growth control function, little is known about their effects on primary metabolism. Here the modulation of gene expression and metabolic adjustment in response to changes in plant (Arabidopsis thaliana) growth imposed on varying the gibberellin regime were evaluated. Polysomal mRNA populations were profiled following treatment of plants with paclobutrazol (PAC), an inhibitor of GA biosynthesis, and gibberellic acid (GA(3)) to monitor translational regulation of mRNAs globally. Gibberellin levels did not affect levels of carbohydrates in plants treated with PAC and/or GA(3). However, the tricarboxylic acid cycle intermediates malate and fumarate, two alternative carbon storage molecules, accumulated upon PAC treatment. Moreover, an increase in nitrate and in the levels of the amino acids was observed in plants grown under a low GA regime. Only minor changes in amino acid levels were detected in plants treated with GA(3) alone, or PAC plus GA(3). Comparison of the molecular changes at the transcript and metabolite levels demonstrated that a low GA level mainly affects growth by uncoupling growth from carbon availability. These observations, together with the translatome changes, reveal an interaction between energy metabolism and GA-mediated control of growth to coordinate cell wall extension, secondary metabolism, and lipid metabolism.}, language = {en} } @misc{JohnsonRammKappeletal.2015, author = {Johnson, Kim L. and Ramm, Sascha and Kappel, Christian and Ward, Sally and Leyser, Ottoline and Sakamoto, Tomoaki and Kurata, Tetsuya and Bevan, Michael W. and Lenhard, Michael}, title = {The tinkerbell (tink) mutation identifies the dual-specificity MAPK phosphatase INDOLE- 3-BUTYRIC ACID-RESPONSE5 (IBR5) as a novel regulator of organ size in Arabidopsis}, series = {PLoS ONE}, journal = {PLoS ONE}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-410245}, pages = {17}, year = {2015}, abstract = {Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants. In a screen for mutants with reduced organ size we have identified a mutation in the active site of the dual-specificity MAPK phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) that we named tinkerbell (tink) due to its small size. Analysis of the tink mutant indicates that IBR5 acts as a novel regulator of organ size that changes the rate of growth in petals and leaves. Organ size and shape regulation by IBR5 acts independently of the KLU growth-regulatory pathway. Microarray analysis of tink/ibr5-6 mutants identified a likely role for this phosphatase in male gametophyte development. We show that IBR5 may influence the size and shape of petals through auxin and TCP growth regulatory pathways.}, language = {en} } @article{HermanussenErofeevScheffler2022, author = {Hermanussen, Michael and Erofeev, Sergei and Scheffler, Christiane}, title = {The socio-endocrine regulation of human growth}, series = {Acta paediatrica : nurturing the child}, journal = {Acta paediatrica : nurturing the child}, publisher = {Wiley}, address = {Hoboken}, issn = {0803-5253}, doi = {10.1111/apa.16504}, pages = {5}, year = {2022}, abstract = {Aim Growth is a multifarious phenomenon that has been studied by nutritionists, economists, paediatric endocrinologists; archaeologists, child psychologists and other experts. Yet, a unifying theory of understanding growth regulation is still lacking. Method Critical review of the literature. Results We summarise evidence linking social competition and its effect on hierarchies in social structures, with the neuronal networks of the ventromedial hypothalamus and body size. The endocrine signalling system regulating growth hormone, Insulin-like-Growth-Factor1 and skeletal growth, is well conserved in the evolution of vertebrata for some 400 million years. The link between size and status permits adaptive plasticity, competitive growth and strategic growth adjustments also in humans. Humans perceive size as a signal of dominance with tallness being favoured and particularly prevalent in the upper social classes. Conclusion Westernised societies are competitive. People are tall, and "open to change." Social values include striving for status and prestige implying socio-economic domination. We consider the transition of political and social values following revolutions and civil wars, as key elements that interact with the evolutionarily conserved neuroendocrine competence for adaptive developmental plasticity, overstimulate the hypothalamic growth regulation and finally lead to the recent historic increases in average height.}, language = {en} } @misc{Rogol2021, author = {Rogol, Alan D.}, title = {Settings Perspective}, series = {Human Biology and Public Health}, volume = {2021}, journal = {Human Biology and Public Health}, number = {1}, editor = {Scheffler, Christiane and Koziel, Slawomir and Hermanussen, Michael and Bogin, Barry}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2748-9957}, doi = {10.52905/hbph.v1.2}, pages = {1 -- 2}, year = {2021}, language = {en} } @misc{IgualGilOstKaschetal.2019, author = {Igual Gil, Carla and Ost, Mario and Kasch, Juliane and Schumann, Sara and Heider, Sarah and Klaus, Susanne}, title = {Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1090}, issn = {1866-8372}, doi = {10.25932/publishup-46054}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-460541}, pages = {11}, year = {2019}, abstract = {Physical activity is an important contributor to muscle adaptation and metabolic health. Growth differentiation factor 15 (GDF15) is established as cellular and nutritional stress-induced cytokine but its physiological role in response to active lifestyle or acute exercise is unknown. Here, we investigated the metabolic phenotype and circulating GDF15 levels in lean and obese male C57BI/6J mice with long-term voluntary wheel running (VWR) intervention. Additionally, treadmill running capacity and exercise-induced muscle gene expression was examined in GDF15-ablated mice. Active lifestyle mimic via VWR improved treadmill running performance and, in obese mice, also metabolic phenotype. The post-exercise induction of skeletal muscle transcriptional stress markers was reduced by VWR. Skeletal muscle GDF15 gene expression was very low and only transiently increased post-exercise in sedentary but not in active mice. Plasma GDF15 levels were only marginally affected by chronic or acute exercise. In obese mice, VWR reduced GDF15 gene expression in different tissues but did not reverse elevated plasma GDF15. Genetic ablation of GDF15 had no effect on exercise performance but augmented the post exercise expression of transcriptional exercise stress markers (Atf3, Atf6, and Xbp1s) in skeletal muscle. We conclude that skeletal muscle does not contribute to circulating GDF15 in mice, but muscle GDF15 might play a protective role in the exercise stress response.}, language = {en} } @misc{HornickBachCrawfurdetal.2017, author = {Hornick, Thomas and Bach, Lennart T. and Crawfurd, Katharine J. and Spilling, Kristian and Achterberg, Eric Pieter and Woodhouse, Jason Nicholas and Schulz, Kai Georg and Brussaard, Corina P. D. and Riebesell, Ulf and Grossart, Hans-Peter}, title = {Ocean acidification impacts bacteria-phytoplankton coupling at low-nutrient conditions}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {667}, issn = {1866-8372}, doi = {10.25932/publishup-41712}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-417126}, pages = {15}, year = {2017}, abstract = {The oceans absorb about a quarter of the annually produced anthropogenic atmospheric carbon dioxide (CO2), resulting in a decrease in surface water pH, a process termed ocean acidification (OA). Surprisingly little is known about how OA affects the physiology of heterotrophic bacteria or the coupling of heterotrophic bacteria to phytoplankton when nutrients are limited. Previous experiments were, for the most part, undertaken during productive phases or following nutrient additions designed to stimulate algal blooms. Therefore, we performed an in situ large-volume mesocosm (similar to 55 m(3)) experiment in the Baltic Sea by simulating different fugacities of CO2 (fCO(2)) extending from present to future conditions. The study was conducted in July-August after the nominal spring bloom, in order to maintain low-nutrient conditions throughout the experiment. This resulted in phytoplankton communities dominated by small-sized functional groups (picophytoplankton). There was no consistent fCO(2)-induced effect on bacterial protein production (BPP), cell-specific BPP (csBPP) or biovolumes (BVs) of either free-living (FL) or particle-associated (PA) heterotrophic bacteria, when considered as individual components (univariate analyses). Permutational Multivariate Analysis of Variance (PERMANOVA) revealed a significant effect of the fCO(2) treatment on entire assemblages of dissolved and particulate nutrients, metabolic parameters and the bacteria-phytoplankton community. However, distance-based linear modelling only identified fCO(2) as a factor explaining the variability observed amongst the microbial community composition, but not for explaining variability within the metabolic parameters. This suggests that fCO(2) impacts on microbial metabolic parameters occurred indirectly through varying physicochemical parameters and microbial species composition. Cluster analyses examining the co-occurrence of different functional groups of bacteria and phytoplankton further revealed a separation of the four fCO(2)-treated mesocosms from both control mesocosms, indicating that complex trophic interactions might be altered in a future acidified ocean. Possible consequences for nutrient cycling and carbon export are still largely unknown, in particular in a nutrient-limited ocean.}, language = {en} } @phdthesis{Geissler2008, author = {Geißler, Katja}, title = {Lebensstrategien seltener Stromtalpflanzen : aut{\"o}kologische Untersuchung von Cnidium dubium, Gratiola officinalis und Juncus atratus unter besonderer Ber{\"u}cksichtigung ihrer Stressresistenz}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17468}, school = {Universit{\"a}t Potsdam}, year = {2008}, abstract = {Die vorliegende Dissertation behandelt die {\"O}kologie von Cnidium dubium (Schkuhr) Thell. (Sumpf-Brenndolde), Gratiola officinalis L. (Gottes-Gnadenkraut) und Juncus atratus Krocker (Schwarze Binse), drei gef{\"a}hrdeten Arten, die als sogenannte Stromtalpflanzen in Mitteleuropa in ihrem Vorkommen eng an die Flussauen gebunden sind. Die Arbeit basiert auf verschiedenen Simulationsexperimenten und Feldstudien in der Unteren Havelniederung, einem „Feuchtgebiet von internationaler Bedeutung". Sie behandelt Themenkomplexe wie das Samenbankverhalten, die Samenkeimung, die Stickstofflimitierung, die Konkurrenzkraft, das Verhalten der Pflanzen nach einer Sommertrockenheit und nach einer Winter/Fr{\"u}hjahrs{\"u}berflutung. Ferner widmet sie sich der Populationsbiologie der Arten und dem Verhalten der Pflanzen nach besonderen St{\"o}rungsereignissen wie Mahd, Herbivorie und der Sommerflut 2002. Der Leser erf{\"a}hrt, wie die Pflanzen in verschiedenen Lebensphasen auf die auentypische Umwelt reagieren und erh{\"a}lt umfassende Einblicke in physiologische Mechanismen, die der Anpassung an die typischen Bedingungen einer mitteleurop{\"a}ischen Flussaue dienen. Eine Interpretation der Ergebnisse zeigt auf, welche der spezifischen Eigenschaften zur Gef{\"a}hrdung der drei Stromtalarten beitragen. Die Arbeit ist f{\"u}r den Arten-, Biotop- und Landschaftsschutz interessant. Dar{\"u}ber hinaus bietet sie zahlreiche Ankn{\"u}pfungspunkte zur {\"o}kophysiologischen Grundlagenforschung. Die verst{\"a}rkte Nutzung physiologischer Methoden bei der Kl{\"a}rung {\"o}kologischer Fragestellungen wird angeregt.}, language = {de} } @phdthesis{Pietzker2003, author = {Pietzker, Christian}, title = {In-situ Wachstumsuntersuchungen beim reaktiven Anlassen von Cu, In Schichten in elementarem Schwefel}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-0001219}, school = {Universit{\"a}t Potsdam}, year = {2003}, abstract = {In dieser Arbeit wurde das reaktive Anlassen von d{\"u}nnen Kupfer-Indium-Schichten in elementarem Schwefel mittels energiedispersiver R{\"o}ntgenbeugung untersucht. Durch die simultane Aufnahme der R{\"o}ntgenspektren und der Messung der diffusen Reflexion von Laserlicht der Wellenl{\"a}nge 635 nm an der Oberfl{\"a}che der Probe w{\"a}hrend des Schichtwachstums von CuInS2 konnte eine Methode zur Prozesskontrolle f{\"u}r ein Herstellungsverfahren von CuInS2 etabliert werden. Die Bildung von CuInS2 aus Kupfer-Indium-Vorl{\"a}uferschichten wird dominiert von Umwandlungen der intermetallischen Phasen. CuInS2 w{\"a}chst innerhalb der Aufheizperiode ab einer Temperatur von ca. 200°C aus der Phase Cu11In9. Jedoch zerf{\"a}llt letztere metallische Phase in Cu16In9 und fl{\"u}ssiges Indium bei einer Temperatur von ca. 310°C. Das fl{\"u}ssige Indium reagiert im Falle von Kupferarmut mit dem Schwefel und f{\"u}hrt zu einem zus{\"a}tzlichen Reaktionspfad {\"u}ber InS zu CuIn5S8. Unter Pr{\"a}parationsbedingungen mit Kupfer{\"u}berschuss wird das Indium in einer intermetallischen Phase gebunden.Erstmals konnte die Phase Digenite bei Temperaturen {\"u}ber 240°C beobachtet werden. Beim Abk{\"u}hlen auf Raumtemperatur wandelt sich diese Phase unter dem Verbrauch von Schwefel in Covellite um.F{\"u}r Proben mit Kupfer{\"u}berschuss konnte eine Wachstumskinetik proportional zur Temperatur beobachtet werden. Dieses Verhalten wurde durch eine stress-induzierte Diffusion als dominierenden Reaktionsmechanismus interpretiert. Dabei werden w{\"a}hrend der Bildung von CuInS2 durch unterschiedliche Ausdehnungen der metallischen und sulfidischen Schichten eine Spannung in der CuInS2-Schicht induziert, die nach {\"U}berschreiten einer Grenzspannung zu Rissen in der CuInS2-Schicht f{\"u}hrt. Entlang dieser Risse findet ein schneller Transport der Metalle zur Oberfl{\"a}che, wo diese mit dem Schwefel reagieren k{\"o}nnen, statt. Die Risse heilen durch die Bildung neuen Sulfids wieder aus.}, language = {de} } @article{PetrovSchippersBeninaetal.2013, author = {Petrov, Veselin and Schippers, Jos and Benina, Maria and Minkov, Ivan and M{\"u}ller-R{\"o}ber, Bernd and Gechev, Tsanko S.}, title = {In search for new players of the oxidative stress network by phenotyping an Arabidopsis T-DNA mutant collection on reactive oxygen species-eliciting chemicals}, series = {Plant omics}, volume = {6}, journal = {Plant omics}, number = {1}, publisher = {Southern Cross Publ.}, address = {Lismore}, issn = {1836-0661}, pages = {46 -- 54}, year = {2013}, abstract = {The ability of some chemical compounds to cause oxidative stress offers a fast and convenient way to study the responses of plants to reactive oxygen species (ROS). In order to unveil potential novel genetic players of the ROS-regulatory network, a population of similar to 2,000 randomly selected Arabidopsis thaliana T-DNA insertion mutants was screened for ROS sensitivity/resistance by growing seedlings on agar medium supplemented with stress-inducing concentrations of the superoxide-eliciting herbicide methyl viologen or the catalase inhibitor 3-amino-triazole. A semi-robotic setup was used to capture and analyze images of the chemically treated seedlings which helped interpret the screening results by providing quantitative information on seedling area and healthy-to-chlorotic tissue ratios for data verification. A ROS-related phenotype was confirmed in three of the initially selected 33 mutant candidates, which carry T-DNA insertions in genes encoding a Ring/Ubox superfamily protein, ABI5 binding protein 1 (AFP1), previously reported to be involved in ABA signaling, and a protein of unknown function, respectively. In addition, we identified six mutants, most of which have not been described yet, that are related to growth or chloroplast development and show defects in a ROS-independent manner. Thus, semi-automated image capturing and phenotyping applied on publically available T-DNA insertion collections adds a simple means for discovering novel mutants in complex physiological processes and identifying the genes involved.}, language = {en} } @misc{HermanussenSchefflerGrothetal.2015, author = {Hermanussen, Michael and Scheffler, Christiane and Groth, Detlef and Aßmann, Christian}, title = {Height and skeletal morphology in relation to modern life style}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {869}, issn = {1866-8372}, doi = {10.25932/publishup-43481}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-434814}, pages = {7}, year = {2015}, abstract = {Height and skeletal morphology strongly relate to life style. Parallel to the decrease in physical activity and locomotion, modern people are slimmer in skeletal proportions. In German children and adolescents, elbow breadth and particularly relative pelvic breadth (50th centile of bicristal distance divided by body height) have significantly decreased in recent years. Even more evident than the changes in pelvic morphology are the rapid changes in body height in most modern countries since the end-19th and particularly since the mid-20th century. Modern Japanese mature earlier; the age at take-off (ATO, the age at which the adolescent growth spurt starts) decreases, and they are taller at all ages. Preece-Baines modelling of six national samples of Japanese children and adolescents, surveyed between 1955 and 2000, shows that this gain in height is largely an adolescent trend, whereas height at take-off (HTO) increased by less than 3 cm since 1955; adolescent growth (height gain between ATO and adult age) increased by 6 cm. The effect of globalization on the modern post-war Japanese society ("community effect in height") on adolescent growth is discussed.}, language = {en} }