@article{HardyBertinTorresRendonetal.2018,
  author    = {Hardy, John G. and Bertin, Annabelle and Torres-Rendon, Jose Guillermo and Leal-Egana, Aldo and Humenik, Martin and Bauer, Felix and Walther, Andreas and C{\"o}lfen, Helmut and Schlaad, Helmut and Scheibel, Thomas R.},
  title     = {Facile photochemical modification of silk protein-based biomaterials},
  series = {Macromolecular bioscience},
  volume    = {18},
  journal   = {Macromolecular bioscience},
  number    = {11},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1616-5187},
  doi       = {10.1002/mabi.201800216},
  pages     = {6},
  year      = {2018},
  abstract  = {Silk protein-based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein-based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk-based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer-modified silks are mineralized. The PAA- and PMAA-functionalized silks are mineralized with calcium carbonate, whereas the PAAm-functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations.},
  language  = {en}
}
@article{ThielkeSeckerSchlaadetal.2016,
  author    = {Thielke, Michael W. and Secker, Christian and Schlaad, Helmut and Theato, Patrick},
  title     = {Electrospinning of Crystallizable Polypeptoid Fibers},
  series = {Macromolecular rapid communications},
  volume    = {37},
  journal   = {Macromolecular rapid communications},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1022-1336},
  doi       = {10.1002/marc.201500502},
  pages     = {100 -- 104},
  year      = {2016},
  abstract  = {A unique fabrication process of low molar mass, crystalline polypeptoid fibers is described. Thermoresponsive fiber mats are prepared by electrospinning a homogeneous blend of semicrystalline poly(N-(n-propyl) glycine) (PPGly; 4.1 kDa) with high molar mass poly(ethylene oxide) (PEO). Annealing of these fibers at approximate to 100 degrees C selectively removes the PEO and produces stable crystalline fiber mats of pure PPGly, which are insoluble in aqueous solution but can be redissolved in methanol or ethanol. The formation of water-stable polypeptoid fiber mats is an important step toward their utilization in biomedical applications such as tissue engineering or wound dressing.},
  language  = {en}
}
@article{HardyTorresRendonLealEganaetal.2016,
  author    = {Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Egana, Aldo and Walther, Andreas and Schlaad, Helmut and Coelfen, Helmut and Scheibel, Thomas R.},
  title     = {Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering},
  series = {Materials},
  volume    = {9},
  journal   = {Materials},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1996-1944},
  doi       = {10.3390/ma9070560},
  pages     = {93 -- 108},
  year      = {2016},
  abstract  = {Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.},
  language  = {en}
}
@misc{HardyTorresRendonLealEganaetal.2017,
  author    = {Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Ega{\~n}a, Aldo and Walther, Andreas and Schlaad, Helmut and C{\"o}lfen, Helmut and Scheibel, Thomas R.},
  title     = {Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-400519},
  pages     = {13},
  year      = {2017},
  abstract  = {Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.},
  language  = {en}
}
@article{SeckerBrosnanLuxenhoferetal.2015,
  author    = {Secker, Christian and Brosnan, Sarah M. and Luxenhofer, Robert and Schlaad, Helmut},
  title     = {Poly(alpha-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial},
  series = {Macromolecular bioscience},
  volume    = {15},
  journal   = {Macromolecular bioscience},
  number    = {7},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1616-5187},
  doi       = {10.1002/mabi.201500023},
  pages     = {881 -- 891},
  year      = {2015},
  abstract  = {Polypeptoids have been of great interest in the polymer science community since the early half of the last century; however, they had been basically forgotten materials until the last decades in which they have enjoyed an exciting revival. In this mini-review, we focus on the recent developments in polypeptoid chemistry, with particular focus on polymers synthesized by the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs). Specifically, we will review traditional monomer synthesis (such as Leuchs, Katchalski, and Kricheldorf) and recent advances in polymerization methods to yield both linear, cyclic, and functional polymers, solution and bulk thermal properties, and preliminary results on the use of polypeptoids as biomaterials (i.e immunogenicity, biodistribution, degradability, and drug delivery).},
  language  = {en}
}