@article{DeyouMarcoHeydenreichetal.2017, author = {Deyou, Tsegaye and Marco, Makungu and Heydenreich, Matthias and Pan, Fangfang and Gruhonjic, Amra and Fitzpatrick, Paul A. and Koch, Andreas and Derese, Solomon and Pelletier, Jerry and Rissanen, Kari and Yenesew, Abiy and Erdelyi, Mate}, title = {Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp teitensis}, series = {Journal of natural products}, volume = {80}, journal = {Journal of natural products}, publisher = {American Chemical Society}, address = {Washington}, issn = {0163-3864}, doi = {10.1021/acs.jnatprod.7b00255}, pages = {2060 -- 2066}, year = {2017}, abstract = {A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 mu M, respectively.}, language = {en} }