TY  - JOUR
A1  - Tong, Hao
A1  - Küken, Anika
A1  - Nikoloski, Zoran
T1  - Integrating molecular markers into metabolic models improves genomic selection for Arabidopsis growth
T2  - Nature Communications
N2  - The current trends of crop yield improvements are not expected to meet the projected rise in demand. Genomic selection uses molecular markers and machine learning to identify superior genotypes with improved traits, such as growth. Plant growth directly depends on rates of metabolic reactions which transform nutrients into the building blocks of biomass. Here, we predict growth of Arabidopsis thaliana accessions by employing genomic prediction of reaction rates estimated from accession-specific metabolic models. We demonstrate that, comparing to classical genomic selection on the available data sets for 67 accessions, our approach improves the prediction accuracy for growth within and across nitrogen environments by 32.6% and 51.4%, respectively, and from optimal nitrogen to low carbon environment by 50.4%. Therefore, integration of molecular markers into metabolic models offers an approach to predict traits directly related to metabolism, and its usefulness in breeding can be examined by gathering matching datasets in crops. An increase in genomic selection (GS) accuracy can accelerate genetic gain by shortening the breeding cycles. Here, the authors introduce a network-based GS method that uses metabolic models and improves the prediction accuracy of Arabidopsis growth within and across environments.
Y1  - 2020
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/59328
SN  - 2041-1723
VL  - 11
IS  - 1
PB  - Nature Publishing Group UK
CY  - London
ER  -