TY  - JOUR
A1  - Ouni, Meriem
A1  - Schürmann, Annette
T1  - Epigenetic contribution to obesity
T2  - Mammalian genome
N2  - Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It includes information on epigenetic alterations which occur in response to fat-enriched diets, exercise and metabolic surgery and discusses the potential of interventions to reverse epigenetic modifications.
Y1  - 2020
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/58928
SN  - 0938-8990
SN  - 1432-1777
VL  - 31
IS  - 5-6
SP  - 134
EP  - 145
PB  - Springer
CY  - New York, NY ; Berlin ; Heidelberg [u.a.]
ER  -