TY  - JOUR
A1  - Villatoro, José Andrés
A1  - Zühlke, Martin
A1  - Riebe, Daniel
A1  - Beitz, Toralf
A1  - Weber, Marcus
A1  - Riedel, Jens
A1  - Löhmannsröben, Hans-Gerd
T1  - IR-MALDI ion mobility spectrometry: physical source characterization and application as HPLC detector
T2  - International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry
N2  - Infrared matrix-assisted laser dispersion and ionization (IR-MALDI) in combination with ion mobility (IM) spectrometry enables the direct analysis of biomolecules in aqueous solution. The release of ions directly from an aqueous solution is based on a phase explosion, induced by the absorption of an IR laser pulse, which disperses the liquid as vapor, nano-and micro-droplets. The ionization process is characterized initially by a broad spatial distribution of the ions, which is a result of complex fluid dynamics and desolvation kinetics. These processes have a profound effect on the shape and width of the peaks in the IM spectra. In this work, the transport of ions by the phase explosion-induced shockwave could be studied independently from the transport by the electric field. The shockwave-induced mean velocities of the ions at different time scales were determined through IM spectrometry and shadowgraphy. The results show a deceleration of the ions from 118 m.s(-1) at a distance of 400 mu m from the liquid surface to 7.1 m.s(-1) at a distance of 10 mm, which is caused by a pile-up effect. Furthermore, the desolvation kinetics were investigated and a first-order desolvation constant of 325 +/- 50 s(-1) was obtained. In the second part, the IR-MALDI-IM spectrometer is used as an HPLC detector for the two-dimensional separation of a pesticide mixture.
KW  - Ion mobility spectrometry
KW  - IR-MALDI
KW  - Shadowgraphy
KW  - Laser
KW  - Imaging
KW  - HPLC
Y1  - 2016
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/44687
SN  - 1435-6163
SN  - 1865-4584
VL  - 19
SP  - 197
EP  - 207
PB  - Springer
CY  - Heidelberg
ER  -